33 results on '"Thong PM"'
Search Results
2. Impact of COVID-19 on diagnosis of tuberculosis and tuberculosis infection in South America, Asia, and Africa.
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Silva DR, Centis R, D'Ambrosio L, Mello FCQ, Pereira GR, Aguirre S, Al-Abri S, Al-Thohli K, Yaquobi FA, Calnan M, Teixeira RC, Inwentarz S, Palmero DJ, Piubello A, Sharma S, Souleymane MB, Soumana A, Tham SM, Thong PM, Udwadia ZF, Boom MVD, Sotgiu G, and Migliori GB
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- Humans, South America epidemiology, Africa epidemiology, Asia epidemiology, Pandemics, COVID-19 epidemiology, Tuberculosis diagnosis, Tuberculosis epidemiology, SARS-CoV-2
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- 2024
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3. Orbital rhabdomyosarcoma in a 19-year-old male patient: A case report and literature review.
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Nhung TH, Minh VL, Tuyet TT, Cuong TM, Lam NL, Trang HT, Quy NX, Thong PM, Thanh DK, and Duc NM
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Rhabdomyosarcoma (RMS) is the most common mesenchymal tumor in children and adolescents, with 10% of cases occurring in the orbits. RMS should be suspected whenever children present with rapidly progressing unilateral exophthalmos. Its symptoms depend on the lesion's origin and location. We report the clinical case of a 19-year-old male patient admitted to the hospital because of blurred vision and bulging eyes that gradually increased over several months. Magnetic resonance imaging showed a mass located mainly in the left orbit, pushing and deforming but not invading the eyeball. The lesion had grown into the left ethmoid sinus wall. The histopathological incisional biopsy results were with alveolar RMS., (© 2023 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
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- 2023
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4. COVID-19, the escalation of diabetes mellitus and the repercussions on tuberculosis.
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Thong PM, Chong HT, Chang AJW, and Ong CWM
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- Humans, Pandemics, Communicable Disease Control, COVID-19 epidemiology, Diabetes Mellitus epidemiology, Diabetes Mellitus diagnosis, Tuberculosis, Miliary
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The COVID-19 pandemic has significantly disrupted global tuberculosis (TB) control efforts. The mobilization of healthcare resources and personnel to combat the pandemic, and the nationwide lockdown measures resulted in an accumulation of a large number of undiagnosed TB cases. Exacerbating the situation, recent meta-analyses showed that COVID-19-induced diabetes mellitus (DM) is on the increase. DM is an established risk factor for TB disease and worsens outcomes. Patients with concurrent DM and TB had more lung cavitary lesions, and are more likely to fail TB treatment and suffer disease relapse. This may pose a significant challenge to TB control in low- and middle-income countries where a high TB burden is found. There is a need to step up the efforts to end the TB epidemic, which include increased screening for DM among patients with TB, optimizing glycemic control among patients with TB-DM, and intensifying TB-DM research to improve treatment outcomes for patients with TB-DM., Competing Interests: Declaration of competing interest The authors have no competing interests to declare., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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- 2023
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5. Correction to: Nos2 -/- mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis.
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Poh XY, Hong JM, Bai C, Miow QH, Thong PM, Wang Y, Rajarethinam R, Ding CSL, and Ong CWM
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- 2022
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6. The crucial need for tuberculosis translational research in the time of COVID-19.
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Loh FK, Thong PM, and Ong CWM
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- Humans, SARS-CoV-2, Translational Research, Biomedical, COVID-19, Tuberculosis epidemiology
- Abstract
Competing Interests: CWMO has received speaking fees from Qiagen, outside this work. The other authors declare no competing interests.
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- 2022
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7. Country-specific lockdown measures in response to the COVID-19 pandemic and its impact on tuberculosis control: a global study.
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Migliori GB, Thong PM, Alffenaar JW, Denholm J, Tadolini M, Alyaquobi F, Al-Abri S, Blanc FX, Buonsenso D, Chakaya J, Cho JG, Codecasa LR, Danila E, Duarte R, Dukpa R, García-García JM, Gualano G, Kurhasani X, Manika K, Mello FCQ, Pahl K, Rendon A, Sotgiu G, Souleymane MB, Thomas TA, Tiberi S, Kunst H, Udwadia ZF, Goletti D, Centis R, D'Ambrosio L, and Silva DR
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- Communicable Disease Control, Humans, Pandemics prevention & control, COVID-19 epidemiology, COVID-19 prevention & control, Influenza, Human epidemiology, Tuberculosis
- Abstract
The objective of this study was to describe country-specific lockdown measures and tuberculosis indicators collected during the first year of the COVID-19 pandemic. Data on lockdown/social restrictions (compulsory face masks and hand hygiene; international and local travel restrictions; restrictions to family visits, and school closures) were collected from 24 countries spanning five continents. The majority of the countries implemented multiple lockdowns with partial or full reopening. There was an overall decrease in active tuberculosis, drug-resistant tuberculosis, and latent tuberculosis cases. Although national lockdowns were effective in containing COVID-19 cases, several indicators of tuberculosis were affected during the pandemic.
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- 2022
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8. Features of International Publications in Vietnamese Radiological Societies after The Enactment of 37/2018/QĐ-TTg.
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Duc NM, Khoa MT, and Thong PM
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Background: In Vietnam, after the enactment of 37/2018/QĐ-TTg, a distinct shift could be observed in the international publications by radiological societies., Objctive: This study examined trends in the international publications achieved by Vietnamese radiological societies following the enactment of 37/2018/QĐ-TTg., Methods: This retrospective study evaluated data that are freely accessible and available online and, therefore, did not require institutional review board approval. We assessed the publication characteristics of the members of four Vietnamese radiological societies: Vietnamese Society of Radiology and Nuclear Medicine (VSRNM, n = 67); Radiological Society of Ho Chi Minh City (RSHCM, n = 25); Vietnamese Society of Ultrasound in Medicine (VSUM, n = 29); and Vietnamese Society of Interventional Radiology (VSIR, n = 18), following the enactment of 37/2018/QĐ-TTg., Results: Following the enactment of 37/2018/QĐ-TTg, we observed that total publications, number of first authors, number of last authors, number of articles indexed in Web of Science, and number of articles indexed in Scopus were significantly higher for the VSRNM and VSIR than for the RSHCM and VSUM. All publication parameters were significantly higher men, individuals who secured professorship, PhD and Master's degree holders, public hospital employees, those in the radiological field, and those in the north and south regions, compared with the values for women, individuals without professorships, Specialist II and I degree holders, private hospital employees, those in the nuclear medicine field, and those in the middle region, respectively., Conclusion: The enactment of 37/2018/QĐ-TTg triggered a new trend in international publication among the members of four Vietnamese radiological societies. However, strong discrepancies remain in total publications, number of first authors, number of last authors, number of articles indexed in Web of Science, and number of articles indexed in Scopus among the members of the four main Vietnamese radiological societies., Competing Interests: There are no conflicts of interest to declare., (© 2022 Nguyen Minh Duc, Mai Trong Khoa, Pham Minh Thong.)
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- 2022
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9. Nos2 -/- mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis.
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Poh XY, Hong JM, Bai C, Miow QH, Thong PM, Wang Y, Rajarethinam R, Ding CSL, and Ong CWM
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- Animals, Disease Models, Animal, Humans, Mice, Mice, Inbred Strains, Nitric Oxide Synthase Type II, Mycobacterium tuberculosis physiology, Tuberculosis, Tuberculosis, Central Nervous System pathology
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Background: Understanding the pathophysiology of central nervous system tuberculosis (CNS-TB) is hampered by the lack of a good pre-clinical model that mirrors the human CNS-TB infection. We developed a murine CNS-TB model that demonstrates neurobehavioral changes with similar immunopathology with human CNS-TB., Methods: We injected two Mycobacterium tuberculosis (M.tb) strains, H37Rv and CDC1551, respectively, into two mouse strains, C3HeB/FeJ and Nos2
-/- mice, either into the third ventricle or intravenous. We compared the neurological symptoms, histopathological changes and levels of adhesion molecules, chemokines, and inflammatory cytokines in the brain induced by the infections through different routes in different strains., Results: Intra-cerebroventricular infection of Nos2-/- mice with M.tb led to development of neurological signs and more severe brain granulomas compared to C3HeB/FeJ mice. Compared with CDC1551 M.tb, H37Rv M.tb infection resulted in a higher neurobehavioral score and earlier mortality. Intra-cerebroventricular infection caused necrotic neutrophil-dominated pyogranulomas in the brain relative to intravenous infection which resulted in disseminated granulomas and mycobacteraemia. Histologically, intra-cerebroventricular infection of Nos2-/- mice with M.tb resembled human CNS-TB brain biopsy specimens. H37Rv intra-cerebroventricular infected mice demonstrated higher brain concentrations of inflammatory cytokines, chemokines and adhesion molecule ICAM-1 than H37Rv intravenous-infected mice., Conclusions: Intra-cerebroventricular infection of Nos2-/- mice with H37Rv creates a murine CNS-TB model that resembled human CNS-TB immunopathology, exhibiting the worst neurobehavioral score with a high and early mortality reflecting disease severity and its associated neurological morbidity. Our murine CNS-TB model serves as a pre-clinical platform to dissect host-pathogen interactions and evaluate therapeutic agents for CNS-TB., (© 2022. The Author(s).)- Published
- 2022
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10. Gauging the impact of the COVID-19 pandemic on tuberculosis services: a global study.
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Migliori GB, Thong PM, Alffenaar JW, Denholm J, Tadolini M, Alyaquobi F, Blanc FX, Buonsenso D, Cho JG, Codecasa LR, Danila E, Duarte R, García-García JM, Gualano G, Rendon A, Silva DR, Souleymane MB, Tham SM, Thomas TA, Tiberi S, Udwadia ZF, Goletti D, Centis R, D'Ambrosio L, Sotgiu G, and Ong CWM
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- Humans, Pandemics, SARS-CoV-2, COVID-19, Tuberculosis epidemiology, Tuberculosis therapy
- Abstract
Competing Interests: Conflict of interest: G.B. Migliori has nothing to disclose. Conflict of interest: P.M. Thong has nothing to disclose. Conflict of interest: J-W. Alffenaar has nothing to disclose. Conflict of interest: J. Denholm has nothing to disclose. Conflict of interest: M. Tadolini has nothing to disclose. Conflict of interest: F. Alyaquobi has nothing to disclose. Conflict of interest: F-X. Blanc has nothing to disclose. Conflict of interest: D. Buonsenso has nothing to disclose. Conflict of interest: J-G. Cho has nothing to disclose. Conflict of interest: L.R. Codecasa has nothing to disclose. Conflict of interest: E. Danila has nothing to disclose. Conflict of interest: R. Duarte has nothing to disclose. Conflict of interest: J-M. García-García has nothing to disclose. Conflict of interest: G. Gualano has nothing to disclose. Conflict of interest: A. Rendon has nothing to disclose. Conflict of interest: D.R. Silva has nothing to disclose. Conflict of interest: M.B. Souleymane has nothing to disclose. Conflict of interest: S.M. Tham has nothing to disclose. Conflict of interest: T.A. Thomas has nothing to disclose. Conflict of interest: S. Tiberi has nothing to disclose. Conflict of interest: Z.F. Udwadia has nothing to disclose. Conflict of interest: D. Goletti has nothing to disclose. Conflict of interest: R. Centis has nothing to disclose. Conflict of interest: L. D'Ambrosio has nothing to disclose. Conflict of interest: G. Sotgiu has nothing to disclose. Conflict of interest: C.W.M. Ong reports grants from National Medical Research Council (CSAINV17nov014), personal fees (young investigator award) from Institut Merieux, during the conduct of the study; other (honorarium) from Qiagen, outside the submitted work.
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- 2021
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11. A case report describing the successful separation of ischiopagus tetrapus conjoined twins in Vietnam.
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Dinh TQ, Duc NM, Binh HTT, Hang TT, Xuyen NC, My TT, Bang MTL, and Thong PM
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Ischiopagus conjoined twinning is a rare congenital defect. The surgical separation of conjoined twins is difficult because of the complex anatomy and physiology. Careful preoperative assessment, planning, and effective surgical teams are critically important for achieving a good outcome. We describe the successful separation of ischiopagus tetrapus conjoined twins as a representative case demonstrating the growth of pediatric surgery in southern Vietnam., (© 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
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- 2021
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12. A case report of pericallosal aneurysm successfully treated with flow diverter stents.
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Dung LV, Duc NM, Binh NT, Linh LT, Luu DT, My TT, Huy TD, and Thong PM
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Pericallosal artery aneurysm (PAA) is a relatively uncommon type of intracranial aneurysm that tends to rupture more frequently and cause higher mortality rates than other types of cerebral aneurysms. Surgery to address PAA is difficult due to its deep-seated location, the size of the aneurysmal sac, and the limited surgical field. In recent years, with the development of percutaneous interventions, endovascular treatment has become the preferred, minimally invasive intervention method for the treatment of pericallosal aneurysms. In this article, we present a case of PAA that was successfully treated with flow diversion therapy in a 51-year-old male., Competing Interests: The authors do not report any conflicts of interest., (© 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
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- 2021
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13. Multifocal precursor B-cell lymphoblastic lymphoma in an infant with cardiac involvement: A case report.
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Ninh TP, Duc NM, Trung NN, Duc LA, Ngoc DV, My TT, Sang NV, and Thong PM
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Lymphoma with cardiac involvement is a high-risk lesion, especially in children. We report a rare clinical case of multifocal precursor B-cell lymphoblastic lymphoma in a child with cardiac involvement. A 4-year-old boy presented to the Vietnam National Children's Hospital with a vague headache, but magnetic resonance imaging of the head was normal. After 1 week, the patient showed symptoms of chest pain, fatigue, dyspnea, and abdominal pain. On transthoracic echocardiography and multislice computed tomography of the thorax, a mass was detected in the right atrial wall. Abdominal ultrasound showed a small bowel intussusception, multiple nodules in the intestinal wall, and mesenteric lymph nodes. Histopathology of the bowel confirmed the diagnosis of multifocal precursor B-cell lymphoblastic lymphoma. The patient responded to 3 cycles of chemotherapy for lymphoma. Therefore, combining multiple imaging methods allowed for early diagnosis and improved treatment., (© 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
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- 2021
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14. Cecum perforation due to a fish bone.
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Dung LT, Duc NM, My TT, Linh LT, Luu VD, and Thong PM
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Foreign body (FB) ingestion is a common condition encountered in clinical practice, especially among the pediatric age group; however, this occurrence is rare among adults. Some FBs can induce the perforation of the gastrointestinal tract, including fish bones, chicken bones and toothpicks. The ingestion of FBs is rarely associated with bowel perforation, and most FBs are passed spontaneously. The ingestion of sharp and pointed objects typically produces adverse events related to the upper gastrointestinal system, and FBs are rarely retained in the colon. Bowel perforation caused by the ingestion of FBs should be diagnosed and treated in a timely manner. Here, we present the unusual case of a 51-year-old male who presented to the emergency room with complaints of acute abdominal pain secondary to fish bone ingestion, which triggered cecum perforation., (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
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- 2021
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15. Hypovascular pancreatic neuroendocrine tumor with hepatic metastases: A case report and literature review.
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Doan NV, Duc NM, Ngan VK, Anh NV, Khuyen HK, Nhan NT, Giang BV, and Thong PM
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Hypovascular pancreatic neuroendocrine tumors are uncommon pancreatic tumors and commonly misdiagnosed as pancreatic ductal adenocarcinoma or chronic mass-forming pancreatitis. The liver is the organ most commonly affected by neuroendocrine tumor metastases but hepatic neuroendocrine tumor metastases are quite difficult to discriminate from other hepatic metastases and primary hepatic tumors. We describe a case of a 47-year-old man with incidentally detected multiple hepatic lesions on ultrasound. On further imaging technique including computed tomography and magnetic resonance imaging, the patient had an abnormal hypoenhancing lesion at the pancreatic tail and multiple hyperenhancing hepatic metastases that were diagnosed as hypovascular pancreatic well-differentiated neuroendocrine tumor Grade 2 with multiple hypervascular hepatic metastases after liver biopsy and surgery. Neuroendocrine tumor is a rare etiology among hypoenhancing pancreatic tumors, and must be considered to discriminate from pancreatic adenocarcinomas in cases there are multiple hyperenhancing hepatic metastases on the arterial phase without typical washout on the portal venous phase., (© 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
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- 2021
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16. A rare case of inflammatory myofibroblastic tumor of the vulva in a newborn.
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Lenh BV, Duc NM, My TT, Van ND, Huong BM, Trung HV, Bang MTL, and Thong PM
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Inflammatory myofibroblastic tumor (IMT) is an uncommon neoplasm that rarely arises in the genitourinary system. IMTs in the vulva in infants are extremely rare in the literature. The tumor consists of myofibroblastic spindle cells accompanied by inflammatory cell infiltration. In this article, we aimed to describe the case of IMT in the vulva. A newborn girl presented with a mass in the vulva detected in the prenatal period. The patient was treated with surgery and chemotherapy. Follow-up 8 months after surgery showed no signs of recurrence. In conclusion, IMT has a variable clinical presentation, surgery is the optimal approach, but in cases without complete resection, chemotherapy is essential., (© 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
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- 2021
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17. A rare case of lipomatous pseudohypertrophy of the pancreas.
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Luu VD, Duc NM, My TT, Viet NK, Bang LV, and Thong PM
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Lipomatous pseudohypertrophy of the pancreas is a rare disease with unknown etiology, and the pancreas parenchyma is replaced by pancreatic parenchyma by fat tissue. In this article, we aimed to report the case of a 26-year-old male patient admitted to hospital with loss of appetite for 6 months. Abdominal computed tomography (CT) and magnetic resonance imaging (MRI) scans showed diffuse enlargement and fatty replacement over the whole pancreas, with scattered remnants of pancreatic parenchyma. Histologic results defined lipomatous pseudohypertrophy of the pancreas. To summarize, this case report is to put forward this extremely rare presentation and to sensitize clinicians that this entity can be a cause of exocrine pancreatic insufficiency, which requires patient follow-up for the appropriate treatment., (© 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
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- 2021
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18. Non-functioning adrenocortical carcinoma.
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Lenh BV, Duc NM, Tra My TT, Minh TN, Bang LV, Linh LT, Giang BV, and Thong PM
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Adrenocortical carcinoma (ACC) is a rare malignancy that arises from the adrenal cortex and can be classified as either non-functioning or functioning. A patient with non-functioning ACC may present no specific symptoms. Imaging analysis can provide some information to a clinician who suspects ACC, such as tumor size, density, washout, necrosis, hemorrhage, and calcification. Histopathology is used to confirm and determine the origin of the malignancy and can provide relevant prognostic information. Microscopic findings can be used to obtain information such as the Weiss score, resection surface features, Ki-67 proliferative index, and the degree of capsular and vascular invasion. Surgery can be curative for localized tumors, and adjuvant therapy using mitotane and cytotoxic chemotherapy is often employed for advanced-stage tumors. We describe a case report of a 32-year-old man with a non-functioning ACC that highlights the importance of radiological and pathological features in the diagnosis of ACC and their use as prognostic factors., (© 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
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- 2021
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19. A rare case report of breast sarcoma.
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Sang NV, Duc NM, My TT, Ly TT, Bang LV, and Thong PM
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Malignant tumors that originate from the mesenchymal tissue of the mammary gland, known as breast sarcomas, are very rare and can be divided into 2 types: primary and secondary (therapy-related development). Breast sarcomas are aggressive tumors associated with a poor prognosis. Treatment options include the coordination of surgery, chemotherapy, and radiotherapy. We present a case of a 51-year-old female who presented to the hospital after noticing a palpable mass in the left breast and bloody nipple discharge. These symptoms lasted for more than 4 months. Postoperative histopathology revealed an undifferentiated pleomorphic breast sarcoma. After 8 months of treatment, the patient experienced metastasis to the brain and lungs., (© 2021 The Authors.)
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- 2021
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20. The first case of Trichophyton spp. pneumonia reported in Vietnam.
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Vu LT, Duc NM, Tra My TT, Bang LV, Luu DT, and Thong PM
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A respiratory fungal infection is a severe clinical problem caused by endemic or opportunistic fungi. Although pulmonary fungal infections may be associated with no symptoms, the patient may also present with cough, fever, chest pain, and hemoptysis. Trichophyton spp., a dermatophyte fungus, is a dermatologic pathogen and can cause a deep, sometimes fatal infection. Here, we report the first case of a deep Trichophyton spp. Infection in Vietnam and possibly the first case of Trichophyton spp. pneumonia in the literature, which responded completely to medical therapy. This article highlights the epidemiology of fungal lung infections and describes the clinical approach for when to suspect and how to diagnose this disease., (© 2021 The Author(s).)
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- 2021
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21. Worldwide Effects of Coronavirus Disease Pandemic on Tuberculosis Services, January-April 2020.
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Migliori GB, Thong PM, Akkerman O, Alffenaar JW, Álvarez-Navascués F, Assao-Neino MM, Bernard PV, Biala JS, Blanc FX, Bogorodskaya EM, Borisov S, Buonsenso D, Calnan M, Castellotti PF, Centis R, Chakaya JM, Cho JG, Codecasa LR, D'Ambrosio L, Denholm J, Enwerem M, Ferrarese M, Galvão T, García-Clemente M, García-García JM, Gualano G, Gullón-Blanco JA, Inwentarz S, Ippolito G, Kunst H, Maryandyshev A, Melazzini M, de Queiroz Mello FC, Muñoz-Torrico M, Njungfiyini PB, Palmero DJ, Palmieri F, Piccioni P, Piubello A, Rendon A, Sabriá J, Saporiti M, Scognamiglio P, Sharma S, Silva DR, Souleymane MB, Spanevello A, Tabernero E, Tadolini M, Tchangou ME, Thornton ABY, Tiberi S, Udwadia ZF, Sotgiu G, Ong CWM, and Goletti D
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- Betacoronavirus, COVID-19, Humans, Pandemics, SARS-CoV-2, Tuberculosis epidemiology, Continuity of Patient Care trends, Coronavirus Infections epidemiology, Facilities and Services Utilization trends, Global Health trends, Pneumonia, Viral epidemiology, Tuberculosis therapy
- Abstract
Coronavirus disease has disrupted tuberculosis services globally. Data from 33 centers in 16 countries on 5 continents showed that attendance at tuberculosis centers was lower during the first 4 months of the pandemic in 2020 than for the same period in 2019. Resources are needed to ensure tuberculosis care continuity during the pandemic.
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- 2020
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22. Malignant Ependymoblastoma Mimicking a Benign Pilocytic Astrocytoma.
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Thong PM and Minh Duc N
- Abstract
Ependymoblastoma is an uncommon, exceedingly malignant brain neoplasm that adversely influences children's quality of life. Ependymoblastoma represents a subtype of primitive neuroectodermal tumors, categorized as grade IV, according to the 2007 World Health Organization (WHO) classification of central nervous system tumors. Ependymoblastomas are often located in the supratentorial zone and often associated with the ventricular system. Histopathological sections of the tumor revealed uniform, primitive, small blue cells, with multi-layered rosettes, accompanied by abundant mitoses. The clinical and imaging features of ependymoblastomas are not specific, which can result in misdiagnosis as other brain neoplasms. In this paper, we described the identification of a fourth-ventricular ependymoblastoma that was misdiagnosed as pilocytic astrocytoma, despite the utilization of advanced magnetic resonance imaging (MRI) protocols.
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- 2020
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23. The clinical and subclinical features of spinal cord injury on magnetic resonance imaging of patients with N 2 O intoxication.
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Tuan TA, Minh Duc N, Sy TV, Hung TM, Cuong T, Anh NQ, Luu VD, and Thong PM
- Abstract
Nitrous oxide (N
2 O) is a weak anesthetic gas that was first used in 1844 in the field of dental anesthesia. However, currently, N2 O is being abused for entertainment purposes in the form of N2 O-filled balloons, called funky balls , which can cause many adverse effects, especially nervous system injury. This study aimed to investigate the detailed clinical and subclinical features associated with N2 O intoxication. We retrospectively reviewed 47 patients diagnosed with N2 O intoxication, from May 2018 to July 2019, and collected demographic data, clinical and laboratory tests, and spinal cord magnetic resonance imaging (MRI) findings. The mean time of funky ball use was 8.8 months, with a mean use of 36.3 balls per day. All patients presented with superficial sensory disorders. Reductions in muscle strength, decreased vibration sensation, and decreased or lost tendon reflexes were the most common clinical signs of N2 O intoxication. Romberg sign and Lhermitte sign were observed in 39 patients (83%) and 21 patients (44.7%), respectively. Spinal cord lesions on MRI were observed in 32 patients (68.1%), which mostly presented with an inverted V sign. The total duration of N2 O use, the number of days of using N2 O per week, and the presence of Lhermitte sign (P<0.05) were significantly different between patients with and without spinal cord lesions on MRI. Serum levels of homocysteine and vitamin B12 were significantly different between the time of admission and discharge (P<0.05). Our study indicated that the days of using N2 O per week was significantly associated with Spinal Cord Injuries (SCI) on MRI. According to the Receiver Operating Characteristic (ROC) curve analysis, a cutoff days of using per week value of 2.5 days could predict SCI with a sensitivity of 81.3%, a specificity of 73.3%, and an area under the ROC curve (AUC) of 0.813. Changes in the serum levels of homocysteine and vitamin B12 were effective markers for the evaluation of treatment response., Competing Interests: Conflict of interest: The authors declare no conflict of interest., (©Copyright: the Author(s).)- Published
- 2020
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24. Predatory Open Access Journals are Indexed in Reputable Databases: a Revisiting Issue or an Unsolved Problem.
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Duc NM, Hiep DV, Thong PM, Zunic L, Zildzic M, Donev D, Jankovic SM, Hozo I, and Masic I
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- Bibliometrics, Humans, Access to Information, Open Access Publishing, Peer Review, Research methods, Periodicals as Topic, PubMed
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Introduction: Pseudo journals, hijacked journals, fraudulent journals, fake journals, and predatory journals waste valuable research when authors publish their studies in them., Aim: This article described novel suggested features for the identification of fraudulent journals and aimed to explain this issue to help inexperienced scientists avoid publishing in predatory journals., Methods: The articles related to this topic in were retrieved from PubMed and trustable Internet sources., Results: Unfortunately, some fake journals have made their way into reputable databases, such as PubMed, PubMed Central, MEDLINE, SCOPUS, and Web of Science; thus, the serious question has been raised regarding how we should address this problematic phenomenon. We recommended 28 suggested characteristics of predatory journals for readers to take into consideration., Conclusion: Unaware of the detrimental effects associated with publishing in disreputable journals, inexperienced researchers can fall victim to them. Together, as both readers and writers, we should completely boycott predatory journals., Competing Interests: There are no conflicts of interest., (© 2020 Nguyen Minh Duc, Dang Vinh Hiep, Pham Minh Thong, Lejla Zunic, Muharem Zildzic, Doncho Donev, Slobodan M. Jankovic, Izet Hozo, Izet Masic.)
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- 2020
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25. An Overview of Vietnamese Society of Interventional Radiology.
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Duc NM, Ha HD, and Thong PM
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- Biomedical Research, Congresses as Topic, Humans, Serial Publications, Vietnam, Radiology, Interventional education, Societies, Medical organization & administration
- Abstract
Introduction: The Vietnamese Society of Interventional Radiology (VSIR) is one of the world's youngest interventional radiology (IR) societies, with more than 150 members. During the first decade of the development phase, in addition to a number of achievements, the VSIR has continued to address problematic circumstances., Aim: This article aims to describe the current status of VSIR, to introduce VSIR to other IR societies., Methods: We investigated VSIR, using internet sources and related academic and clinical papers., Results: VSIR was founded in 2010 and has succeeded in advancing education and scientific research during the last 10 years., Conclusion: VSIR is widely involved and accepted in Vietnamese medicine. We recommend the launch of an IR training program and support a unified global IR platform, for the benefit of both clinicians and patients in the near future., Competing Interests: There are no conflicts of interest to declare., (© 2020 Nguyen Minh Duc, Hoang Duc Ha, Pham Minh Thong.)
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- 2020
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26. Impacts of Novel Vietnamese Government Regulations on Radiological PhD and Professorship Candidates: an Initial Report.
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Duc NM, Ha HD, Khoa MT, and Thong PM
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Introduction: In Vietnam, the successful publication of research in indexed journals is mandatory to obtain academic appointments and promotions in medical colleges and institutions, according to the current guidelines established by the State Council for Professorship and Ministry of Education and Training., Aim: This study aimed to investigate the impacts of novel Vietnamese government regulations on radiological PhD and professorship candidates., Methods: This study evaluated freely accessible data, available online, and, therefore, did not require institutional review board approval. We assessed the numbers of radiological PhD candidates at Hanoi Medical University and the numbers of published Vietnamese radiological papers, from 2012 to 2019, indexed in the SCImago database. In addition, we evaluated the numbers of qualified radiological professors and associate professors employed at universities during the same period. We did not include nuclear medicine PhD and professorship candidates, in this study. The data are presented as bar and line charts., Results: Following the enactment of 08/2017/TT-BGDĐT and 37/2018/QĐ-TTg, we observed that the numbers of radiological PhD and professorship candidates were significantly reduced. From 2012 to 2019, only one candidate qualified for appointment as a radiological professor. However, the number of radiological papers rose dramatically during the same time period., Conclusion: The enactment of 08/2017/TT-BGDĐT and 37/2018/QĐ-TTg had strong impacts on the numbers of PhD and professorship candidates. Owing to these new regulations, the number of published, international, peer-reviewed radiological papers has increased; however, some undesired consequences may have occurred, such as papers being published in predatory or suspected predatory journals, double or triple submissions, and plagiarism., Competing Interests: There are no conflicts of interest to declare., (© 2020 Nguyen Minh Duc, Hoang Duc Ha, Mai Trong Khoa, Pham Minh Thong.)
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- 2020
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27. Safety and Efficacy of a Direct Aspiration First-Pass Technique with Large-Bore Catheters for Acute Ischemic Stroke in Vietnam: Experience of a Single Center.
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Luu VD, Kien LH, Tuan TA, Anh NQ, Thien NT, Trang NT, Phuong DV, Ton MD, Thong PM, Cong LC, Trieu VV, Manh NT, and Cuong T
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Purpose: The purpose of this study was to evaluate the safety and efficacy of mechanical thrombectomy with a direct aspiration first-pass technique (ADAPT) using large-bore catheters in patients with acute ischemic stroke due to large vessel occlusion (LVO) in a hospital in Vietnam., Methods: This was a retrospective review of patients with acute ischemic stroke due to LVO who were diagnosed and underwent mechanical thrombectomy using ADAPT with large-bore catheters at Bach Mai Hospital from January 2017 to June 2018., Results: Seventy-three patients (47.9% female; age: 61.29 ± 14.49 years) met study criteria. The average procedure duration was 45.09 ± 38.26 min. Successful recanalization post-ADAPT (thrombolysis in cerebral infarction 2b-3) was achieved in 72.6% (53/73) of patients. Good functional outcome (Modified Rankin Scale 0-2) at 3 months was achieved in 50.7% (37/73), with poor functional outcome in 24.7% (18/73). The 90-day mortality rate was 24.7% (18/73). The hemorrhagic transformation rate was 31.6%, in which 19.2% were symptomatic. Vessel perforation occurred in 5.5% (4/73) of patients but in all cases was associated with the guidewire and not the reperfusion catheter. Vessel dissection occurred in 1.4% (1/73) and vasospasm in 5.5% (4/73) of patients., Conclusion: Mechanical thrombectomy using ADAPT with large-bore catheters for acute ischemic stroke due to LVO is a method that yielded good results in recanalization and clinical recovery in a Vietnamese patient population., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Asian Journal of Neurosurgery.)
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- 2020
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28. Comparing the Efficacy of Radiofrequency Ablation Versus Laser Ablation for Chronic Venous Insufficiency in the Lower Extremities: a Vietnamese Report.
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Tuan TA, Duc NM, Minh LN, Ha HD, Luu VD, and Thong PM
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- Adult, Aged, Ecchymosis epidemiology, Endovascular Procedures, Female, Humans, Hyperpigmentation epidemiology, Hypesthesia epidemiology, Lower Extremity, Male, Middle Aged, Paresthesia epidemiology, Treatment Outcome, Vietnam epidemiology, Laser Therapy methods, Postoperative Complications epidemiology, Radiofrequency Ablation methods, Saphenous Vein surgery, Varicose Veins surgery, Venous Insufficiency surgery
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Introduction: Chronic venous insufficiency (CVI) is a chronic condition, triggered by reflux through the saphenous vein network., Aim: To determine the efficacy of endovenous laser ablation (LA) and radiofrequency ablation (RFA) for CVI treatment in the lower extremities, at the Bach Mai Radiology Center., Methods: This retrospective study was approved by the institutional review board of Bach Mai Hospital. The study recruited 49 people, from August 2016 to April 2018, with recurrent venous insufficiency in the lower extremities and measured 56 ablated veins., Results: In this study, 8 patients (10 veins, with a mean diameter of 5.83 ± 0.96 mm) were treated with RFA, and 41 patients (46 veins, with a mean diameter of 7.96 ± 3.47 mm) were treated with LA. The occlusion rates for LA- and RFA-treated veins were very effective, at 95.7% and 90%, respectively. No significant differences in occlusion rates or clinical improvements were observed between the two ablation methods. On the first day post-treatment, the visual analog score (VAS) value for the LA group was significantly higher than that for the RFA group. Furthermore, ecchymosis, 1 day after treatment, and hyperpigmentation, paresthesia, and numbness, 1 month after treatment, were only observed in the LA group., Conclusion: Both LA and RFA were minimally-invasive and safe therapies. No serious complications requiring further interventions were reported and the treatment effectively improved the clinical symptoms of patients. Based on our study, we recommend that RFA should be considered for moderate dilated saphenous vein cases, whereas LA should be indicated for large dilated saphenous vein cases, with or without aneurysm., Competing Interests: There are no conflicts of interest to declare., (© 2020 Tran Anh Tuan, Nguyen Minh Duc, Le Nguyet Minh, Hoang Duc Ha, Vu Dang Luu, Pham Minh Thong.)
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- 2020
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29. Gender Disparity in Vietnamese Radiological Societies: a Preliminary Observational Study.
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Duc NM, Huy HQ, Keserci B, and Thong PM
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Introduction: The advancement of gender equality within radiology, a predominantly male profession, has currently been a significant concern., Aim: Therefore, in this original study, we aimed to investigate the gender disparity in Vietnamese radiological societies., Methods: No ethical committee or institutional review board approval was needed since the data were publicly available. In this retrospective study, we evaluated the faculties of four main radiological societies in Vietnam: Vietnamese society of radiology and nuclear medicine (VSRNM, n = 67); Radiological society of Ho Chi Minh City (RSHCM, n = 25); Vietnamese society of ultrasound in medicine (VSUM, n = 29); and Vietnamese society of interventional radiology (VSIR, n = 18)., Results: There are significantly fewer women than men in faculties of four main radiological societies (15.1% vs. 84.9%). None of the women served as a professor and leader of any radiological societies. The women with a doctor of philosophy level are relatively low among the four main radiological societies. Also, female interventional and pediatric radiologists are seriously low among four main radiological societies., Conclusions: In Vietnamese radiological societies, gender disparities exist, especially about educational degrees and professorship positions. Future studies are essential to address the underlying roots of the gender gap and aid in the implementation of gender diversity programs and policies., Competing Interests: There are no conflicts of interest to declare., (© 2020 Nguyen Minh Duc, Huynh Quang Huy, Bilgin Keserci, Pham Minh Thong.)
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- 2020
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30. Flow diverter stent for treatment of cerebral aneurysms: A report of 130 patients with 134 aneurysms.
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Binh NT, Luu VD, Thong PM, Cuong NN, Anh NQ, Tuan TA, Linh LT, Thien NT, Uddin MJ, Dinh TC, and Chu DT
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Background: This study aims to report our experience with cerebral aneurysms, which may improve in the treatment with the flow-diverter stent and follow up., Methods: This study was conducted in a consecutive series of 130 patients. 134 procedures were performed for treating these patients in Hanoi Medical University Hospital and Bach Mai Hospital from January 2012 to April 2017. 143 flow diverter stents (Pipeline, FRED and SILK) were used. Aneurysm morphology, stent patency and cerebral parenchyma before and after intervention were analyzed on images of digital subtraction angiography (DSA), computed tomography (CT) and magnetic resonance (MR). The follow-up data after 3-6 months and 12 months were recorded., Results: In 130 patients (31 men, 99 women), aneurysms of internal carotid artery were mostly common (92.6%), especially in cavernous (35.1%) and in para-ophthalmic (40.3%) segments. 83 cases (61.9%) had wide-neck aneurysms, and 16 cases (11.9%) had multiple aneurysms, and only 5 cases (3.7%) had blister-liked aneurysms. Endovascular treatment was successfully performed at rate of 94.8%. In 3 patients, the stent could not be delivered. Mortality and morbidity rates were 1.5% and 3.7%, respectively. MRI and MSCT follow-up at 3 months showed complete or incomplete occlusions of aneurysms was 7.4% or 17.5%, respectively. 3 patients experienced a thromboembolic event (4.3%)., Conclusions: Intracranial aneurysms of cavernous and para-ophthalmic segments of internal carotid artery are mostly common with wide-neck and multi aneurysms. Deployment of flow diverter stent is safe and effective with high rate of successful and low procedural complications., (© 2020 The Author(s).)
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- 2020
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31. Massive Dissecting Aneurysm in the Basilar Tip Artery Treated with Intra-aneurysm and Basilar Artery Coiling.
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Tuan TA, An NH, Van Tuan N, Luu VD, Thong PM, Huy HQ, Duc NM, and Laurent P
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- Adult, Humans, Male, Treatment Outcome, Aortic Dissection surgery, Basilar Artery surgery, Endovascular Procedures methods
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Introduction: Deconstructive versus reconstructive technique remains controversial on the management of acute basilar tip artery dissection., Aim: We introduced a case report of massive dissecting aneurysm in the basilar tip artery treated with intra-aneurysm and basilar artery coiling., Results: A 30-year-old male presented with sudden headache and severe vomiting. Radiographic study showed a large unruptured dissecting aneurysm in the basilar tip artery involving bilateral P1 segment. This aneurysm was treated with intra-aneurysm and basilar artery coiling. Patient was discharge after 7 days without any neurological deficits. Post-operatively, the patient received 75 mg aspirin and 75 mg clopidogrel PO per day for 3 months - then 75 mg aspirin per day for up to 1 year. Angiographic follow-up at 3 months showed a complete occlusion of aneurysmal sac and basilar tip artery without any deficits (mRS 0). Cerebral arteriography at 6 months follow-up confirmed a stable occlusion of aneurysmal sac with a minor recurrence of aneurysm in left P1 segment., Conclusion: Intra-aneurysm and basilar artery coiling is valuable alternative technique to treat complex basilar tip dissecting aneurysm in case of infeasible reconstructive technique. Clinical presentation, aneurysm characteristics and collateral circulation have to be investigated on each case to adopt this technique., Competing Interests: There are no conflicts of interest to declare., (© 2020 Tran Anh Tuan, Nguyen Huu An, Nguyen Van Tuan, Vu Dang Luu, Pham Minh Thong, Huynh Quang Huy, Nguyen Minh Duc, Pierot Laurent.)
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- 2020
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32. A Preliminary Vietnamese Comparative Study of Postgraduate Radiological Thesis Characteristics.
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Duc NM, Huy HQ, Keserci B, and Thong PM
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- Adult, Female, Humans, Male, Retrospective Studies, Vietnam, Young Adult, Academic Dissertations as Topic, Asian People statistics & numerical data, Education, Medical, Graduate statistics & numerical data, Publishing statistics & numerical data, Radiology education, Radiology statistics & numerical data
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Introduction: Each country has its system of the training program, but to be concordant with the world in the radiology field, the process needs to have common points or common criteria. On maintaining the integrity of intersociety collaboration in the field of radiology, it is necessary to understand each country's training program for each specialty., Aim: This retrospective study aims to compare the postgraduate thesis characteristics from various sources in the field of radiology., Methods: This was a retrospective study evaluating data that is publicly available online and at libraries and institutional review board approval, as such, was not demanded. We selected 40 published theses from the library of Pham Ngoc Thach University of Medicine and University of Medicine and Pharmacy at Ho Chi Minh City and Hanoi Medical University in Vietnam which graduated from 2008 to 2018. Of these, there were 10 PhD, 10 specialists II, 10 master's, and 10 residency theses selected., Results: A total of 40 theses were analyzed from participants with a median age of 36.5. The male/female ratio was 23/17. Most of the theses were subspecialty in diagnostic radiology (87.5%) and focused on pathological radiology (95%). Adult patients were the major objectives of the theses accounted for 87.5% with predominant materials of magnetic resonance imaging counted for 47.5%. Theses in PhD group were the largest items regarding the total number of pages as well as the number of figures, and the number of references. Nonetheless, both domestic and international publications related to all theses were truly low., Conclusion: The postgraduate thesis of radiology in Vietnam has many different forms but mainly focuses on diagnostic and pathological radiology with materials of magnetic resonance imaging in adults. The number of international publications regarding the thesis was very small., Competing Interests: There are no conflicts of interest to declare., (© 2020 Nguyen Minh Duc, Huynh Quang Huy, Bilgin Keserci, Pham Minh Thong.)
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- 2020
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33. Vietnamese Society of Radiology and Nuclear Medicine: Past, Current and Future.
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Duc NM, Huy HQ, and Thong PM
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Introduction: Currently, most of continents and countries have its own radiological societies which help to share and update clinical experience and scientific knowledge to make the outcome of routine work become efficacious. Although Vietnam was affected adversely due to war, it also developed fundamentally in radiological field. So as to interact better among radiological societies, we believe that the history and current condition of Vietnamese radiology should be introduced., Aim: Thus, in this paper, we aimed to describe the past, current, and future of Vietnamese Society of Radiology and Nuclear medicine., Methods: We collected the information about Vietnamese Society of Radiology and Nuclear medicine via internet source and publications., Results: Radiological society was established in 1961. Although the society developed successfully during 59 years, there are still some problematic conditions such as gender disparity, insufficiency of human resource and modern modalities., Conclusion: With the appearance of Vietnamese society of radiology and nuclear medicine, many doctors and technicians are close together, and Vietnam has an effective chance for radiology to intergrate into actively global radiological field., Competing Interests: There are no conflicts of interest to declare., (© 2020 Nguyen Minh Duc, Huynh Quang Huy, Pham Minh Thong.)
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- 2019
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