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1. Antigenic Characterization of Circulating and Emerging SARS-CoV-2 Variants in the U.S. throughout the Delta to Omicron Waves

Author

Di, Han, primary, Pusch, Elizabeth A., additional, Jones, Joyce, additional, Kovacs, Nicholas A., additional, Hassell, Norman, additional, Sheth, Mili, additional, Lynn, Kelly Sabrina, additional, Keller, Matthew W., additional, Wilson, Malania M., additional, Keong, Lisa M., additional, Cui, Dan, additional, Park, So Hee, additional, Chau, Reina, additional, Lacek, Kristine A., additional, Liddell, Jimma D., additional, Kirby, Marie K., additional, Yang, Genyan, additional, Johnson, Monique, additional, Thor, Sharmi, additional, Zanders, Natosha, additional, Feng, Chenchen, additional, Surie, Diya, additional, DeCuir, Jennifer, additional, Lester, Sandra N., additional, Atherton, Lydia, additional, Hicks, Heather, additional, Tamin, Azaibi, additional, Harcourt, Jennifer L., additional, Coughlin, Melissa M., additional, Self, Wesley H., additional, Rhoads, Jillian P., additional, Gibbs, Kevin W., additional, Hager, David N., additional, Shapiro, Nathan I., additional, Exline, Matthew C., additional, Lauring, Adam S., additional, Rambo-Martin, Benjamin, additional, Paden, Clinton R., additional, Kondor, Rebecca J., additional, Lee, Justin S., additional, Barnes, John R., additional, Thornburg, Natalie J., additional, Zhou, Bin, additional, Wentworth, David E., additional, and Davis, Charles Todd, additional

Published
2024
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3. Assessment of Molecular, Antigenic, and Pathological Features of Canine Influenza A(H3N2) Viruses That Emerged in the United States

Author

Pulit-Penaloza, Joanna A., Simpson, Natosha, Yang, Hua, Creager, Hannah M., Jones, Joyce, Carney, Paul, Belser, Jessica A., Yang, Genyan, Chang, Jessie, Zeng, Hui, Thor, Sharmi, Jang, Yunho, Killian, Mary Lea, Jenkins-Moore, Melinda, Janas-Martindale, Alicia, Dubovi, Edward, Wentworth, David E., Stevens, James, Tumpey, Terrence M., Davis, C. Todd, and Maines, Taronna R.

Published
2017

4. Update : Increase in Human Infections with Novel Asian Lineage Avian Influenza A(H7N9) Viruses During the Fifth Epidemic — China, October 1, 2016–August 7, 2017

Author

Kile, James C., Ren, Ruiqi, Liu, Liqi, Greene, Carolyn M., Roguski, Katherine, Iuliano, A. Danielle, Jang, Yunho, Jones, Joyce, Thor, Sharmi, Song, Ying, Zhou, Suizan, Trock, Susan C., Dugan, Vivien, Wentworth, David E., Levine, Min Z., Uyeki, Timothy M., Katz, Jacqueline M., Jernigan, Daniel B, Olsen, Sonja J., Fry, Alicia M., Azziz-Baumgartner, Eduardo, and Davis, C. Todd

Published
2017

5. Swine-to-Ferret Transmission of Antigenically Drifted Contemporary Swine H3N2 Influenza A Virus Is an Indicator of Zoonotic Risk to Humans

Author

Souza, Carine K., primary, Kimble, J. Brian, additional, Anderson, Tavis K., additional, Arendsee, Zebulun W., additional, Hufnagel, David E., additional, Young, Katharine M., additional, Gauger, Phillip C., additional, Lewis, Nicola S., additional, Davis, C. Todd, additional, Thor, Sharmi, additional, and Vincent Baker, Amy L., additional

Published
2023
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6. Interspecies Transmission from Pigs to Ferrets of Antigenically Distinct Swine H1 Influenza A Viruses with Reduced Reactivity to Candidate Vaccine Virus Antisera as Measures of Relative Zoonotic Risk

Author

Kimble, J. Brian, primary, Souza, Carine K., additional, Anderson, Tavis K., additional, Arendsee, Zebulun W., additional, Hufnagel, David E., additional, Young, Katharine M., additional, Lewis, Nicola S., additional, Davis, C. Todd, additional, Thor, Sharmi, additional, and Vincent Baker, Amy L., additional

Published
2022
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7. Pathogenesis and transmission of human seasonal and swine-origin A(H1) influenza viruses in the ferret model

Author

Pulit-Penaloza, Joanna A., primary, Brock, Nicole, additional, Jones, Joyce, additional, Belser, Jessica A., additional, Jang, Yunho, additional, Sun, Xiangjie, additional, Thor, Sharmi, additional, Pappas, Claudia, additional, Zanders, Natosha, additional, Tumpey, Terrence M., additional, Davis, C. Todd, additional, and Maines, Taronna R., additional

Published
2022
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9. Antigenic characterization of highly pathogenic avian influenza A(H5N1) viruses with chicken and ferret antisera reveals clade-dependent variation in hemagglutination inhibition profiles

Author

Thi Nguyen, Diep, Shepard, Samuel S., Burke, David Francis, Jones, Joyce, Thor, Sharmi, Nguyen, Long Van, Nguyen, Tho Dang, Balish, Amanda, Hoang, Dang Nguyen, To, Thanh Long, Iqbal, Munir, Wentworth, David E., Spackman, Erica, van Doorn, H Rogier, Davis, C. Todd, and Bryant, Juliet E.

Published
2018
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10. Genetically and Antigenically Divergent Influenza A(H9N2) Viruses Exhibit Differential Replication and Transmission Phenotypes in Mammalian Models

Author

Belser, Jessica A., primary, Sun, Xiangjie, additional, Brock, Nicole, additional, Pappas, Claudia, additional, Pulit-Penaloza, Joanna A., additional, Zeng, Hui, additional, Jang, Yunho, additional, Jones, Joyce, additional, Carney, Paul J., additional, Chang, Jessie, additional, Long, Nguyen Van, additional, Diep, Nguyen Thi, additional, Thor, Sharmi, additional, Di, Han, additional, Yang, Genyan, additional, Cook, Peter W., additional, Creager, Hannah M., additional, Wang, Dayan, additional, McFarland, Jeffrey, additional, Dong, Pham Van, additional, Wentworth, David E., additional, Tumpey, Terrence M., additional, Barnes, John R., additional, Stevens, James, additional, Davis, C. Todd, additional, and Maines, Taronna R., additional

Published
2020
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11. Antigenically Diverse Swine Origin H1N1 Variant Influenza Viruses Exhibit Differential Ferret Pathogenesis and Transmission Phenotypes

Author

Pulit-Penaloza, Joanna A., primary, Jones, Joyce, additional, Sun, Xiangjie, additional, Jang, Yunho, additional, Thor, Sharmi, additional, Belser, Jessica A., additional, Zanders, Natosha, additional, Creager, Hannah M., additional, Ridenour, Callie, additional, Wang, Li, additional, Stark, Thomas J., additional, Garten, Rebecca, additional, Chen, Li-Mei, additional, Barnes, John, additional, Tumpey, Terrence M., additional, Wentworth, David E., additional, Maines, Taronna R., additional, and Davis, C. Todd, additional

Published
2018
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12. Avian Influenza A(H7N2) Virus in Human Exposed to Sick Cats, New York, USA, 2016

Author

Marinova-Petkova, Atanaska, primary, Laplante, Jen, additional, Jang, Yunho, additional, Lynch, Brian, additional, Zanders, Natosha, additional, Rodriguez, Marisela, additional, Jones, Joyce, additional, Thor, Sharmi, additional, Hodges, Erin, additional, De La Cruz, Juan A., additional, Belser, Jessica, additional, Yang, Hua, additional, Carney, Paul, additional, Shu, Bo, additional, Berman, LaShondra, additional, Stark, Thomas, additional, Barnes, John, additional, Havers, Fiona, additional, Yang, Patrick, additional, Trock, Susan C., additional, Fry, Alicia, additional, Gubareva, Larisa, additional, Bresee, Joseph S., additional, Stevens, James, additional, Daskalakis, Demetre, additional, Liu, Dakai, additional, Lee, Christopher T., additional, Torchetti, Mia Kim, additional, Newbury, Sandra, additional, Cigel, Francine, additional, Toohey-Kurth, Kathy, additional, St. George, Kirsten, additional, Wentworth, David E., additional, Lindstrom, Stephen, additional, and Davis, C. Todd, additional

Published
2017
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13. Shifting Clade Distribution, Reassortment, and Emergence of New Subtypes of Highly Pathogenic Avian Influenza A(H5) Viruses Collected from Vietnamese Poultry from 2012 to 2015

Author

Nguyen, Diep T., primary, Jang, Yunho, additional, Nguyen, Tho D., additional, Jones, Joyce, additional, Shepard, Samuel S., additional, Yang, Hua, additional, Gerloff, Nancy, additional, Fabrizio, Thomas, additional, Nguyen, Long V., additional, Inui, Ken, additional, Yang, Genyan, additional, Creanga, Adrian, additional, Wang, Li, additional, Mai, Duong T., additional, Thor, Sharmi, additional, Stevens, James, additional, To, Thanh L., additional, Wentworth, David E., additional, Nguyen, Tung, additional, Pham, Dong V., additional, Bryant, Juliet E., additional, and Davis, C. Todd, additional

Published
2017
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14. Generation and Characterization of Live Attenuated Influenza A(H7N9) Candidate Vaccine Virus Based on Russian Donor of Attenuation

Author

Shcherbik, Svetlana, primary, Pearce, Nicholas, additional, Balish, Amanda, additional, Jones, Joyce, additional, Thor, Sharmi, additional, Davis, Charles Todd, additional, Pearce, Melissa, additional, Tumpey, Terrence, additional, Cureton, David, additional, Chen, Li-Mei, additional, Villanueva, Julie, additional, and Bousse, Tatiana L., additional

Published
2015
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15. Detection and Characterization of Clade 1 Reassortant H5N1 Viruses Isolated from Human Cases in Vietnam during 2013

Author

Thor, Sharmi W., primary, Nguyen, Hieu, additional, Balish, Amanda, additional, Hoang, Anh Nguyen, additional, Gustin, Kortney M., additional, Nhung, Pham Thi, additional, Jones, Joyce, additional, Thu, Ngoc Nguyen, additional, Davis, William, additional, Ngoc, Thao Nguyen Thi, additional, Jang, Yunho, additional, Sleeman, Katrina, additional, Villanueva, Julie, additional, Kile, James, additional, Gubareva, Larisa V., additional, Lindstrom, Stephen, additional, Tumpey, Terrence M., additional, Davis, C. Todd, additional, and Long, Nguyen Thanh, additional

Published
2015
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16. Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013

Author

Rith, Sareth, primary, Davis, C. Todd, additional, Duong, Veasna, additional, Sar, Borann, additional, Horm, Srey Viseth, additional, Chin, Savuth, additional, Ly, Sovann, additional, Laurent, Denis, additional, Richner, Beat, additional, Oboho, Ikwo, additional, Jang, Yunho, additional, Davis, William, additional, Thor, Sharmi, additional, Balish, Amanda, additional, Iuliano, A. Danielle, additional, Sorn, San, additional, Holl, Davun, additional, Sok, Touch, additional, Seng, Heng, additional, Tarantola, Arnaud, additional, Tsuyuoka, Reiko, additional, Parry, Amy, additional, Chea, Nora, additional, Allal, Lotfi, additional, Kitsutani, Paul, additional, Warren, Dora, additional, Prouty, Michael, additional, Horwood, Paul, additional, Widdowson, Marc-Alain, additional, Lindstrom, Stephen, additional, Villanueva, Julie, additional, Donis, Ruben, additional, Cox, Nancy, additional, and Buchy, Philippe, additional

Published
2014
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17. Emergence of multiple clade 2.3.2.1 influenza A (H5N1) virus subgroups in Vietnam and detection of novel reassortants

Author

Creanga, Adrian, primary, Thi Nguyen, Diep, additional, Gerloff, Nancy, additional, Thi Do, Hoa, additional, Balish, Amanda, additional, Dang Nguyen, Hoang, additional, Jang, Yunho, additional, Thi Dam, Vui, additional, Thor, Sharmi, additional, Jones, Joyce, additional, Simpson, Natosha, additional, Shu, Bo, additional, Emery, Shannon, additional, Berman, LaShondra, additional, Nguyen, Ha T., additional, Bryant, Juliet E., additional, Lindstrom, Steve, additional, Klimov, Alexander, additional, Donis, Ruben O., additional, Davis, C.Todd, additional, and Nguyen, Tung, additional

Published
2013
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19. Antigenic characterization of highly pathogenic avian influenza A(H5N1) viruses with chicken and ferret antisera reveals clade-dependent variation in hemagglutination inhibition profiles

Author

Thi Nguyen, Diep, Shepard, Samuel S, Burke, David Francis, Jones, Joyce, Thor, Sharmi, Nguyen, Long Van, Nguyen, Tho Dang, Balish, Amanda, Hoang, Dang Nguyen, To, Thanh Long, Iqbal, Munir, Wentworth, David E, Spackman, Erica, Van Doorn, H Rogier, Davis, C Todd, and Bryant, Juliet E

Subjects
Male, Influenza A Virus, H5N1 Subtype, Immune Sera, Ferrets, virus diseases, Hemagglutinin Glycoproteins, Influenza Virus, Chick Embryo, Hemagglutination Inhibition Tests, Antibodies, Viral, Antigenic Variation, 3. Good health, Species Specificity, Vietnam, Influenza in Birds, Animals, Female, Chickens, Phylogeny, Poultry Diseases
Abstract

Highly pathogenic avian influenza (HPAI) A(H5N1) viruses pose a significant economic burden to the poultry industry worldwide and have pandemic potential. Poultry vaccination against HPAI A(H5N1) viruses has been an important component of HPAI control measures and has been performed in Vietnam since 2005. To systematically assess antigenic matching of current vaccines to circulating field variants, we produced a panel of chicken and ferret antisera raised against historical and contemporary Vietnamese reference viruses representing clade variants that were detected between 2001 and 2014. The antisera were used for hemagglutination inhibition (HI) assays to generate data sets for analysis by antigenic cartography, allowing for a direct comparison of results from chicken or ferret antisera. HI antigenic maps, developed with antisera from both hosts, revealed varying patterns of antigenic relationships and clustering of viruses that were dependent on the clade of viruses analyzed. Antigenic relationships between existing poultry vaccines and circulating field viruses were also aligned with in vivo protection profiles determined by previously reported vaccine challenge studies. Our results establish the feasibility and utility of HPAI A(H5N1) antigenic characterization using chicken antisera and support further experimental and modeling studies to investigate quantitative relationships between genetic variation, antigenic drift and correlates of poultry vaccine protection in vivo.

20. Antigenic characterization of highly pathogenic avian influenza A(H5N1) viruses with chicken and ferret antisera reveals clade-dependent variation in hemagglutination inhibition profiles

Author

Samuel S. Shepard, Tho Dang Nguyen, H. Rogier van Doorn, Juliet E. Bryant, Thanh Long To, Erica Spackman, Diep T. Nguyen, Long Van Nguyen, David E. Wentworth, Dang Nguyen Hoang, Joyce Jones, Munir Iqbal, Sharmi Thor, David F. Burke, Amanda Balish, C. Todd Davis, Thor, Sharmi [0000-0002-0234-5403], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Male, Hemagglutination Inhibition Tests, Epidemiology, Immunology, Hemagglutinin Glycoproteins, Influenza Virus, Chick Embryo, Biology, medicine.disease_cause, Antibodies, Viral, Microbiology, Antigenic drift, Article, 03 medical and health sciences, Species Specificity, Virology, Drug Discovery, Influenza A virus, medicine, Antigenic variation, Animals, Clade, Phylogeny, Poultry Diseases, Hemagglutination assay, Influenza A Virus, H5N1 Subtype, Immune Sera, Ferrets, virus diseases, General Medicine, Antigenic Variation, Influenza A virus subtype H5N1, 3. Good health, Vaccination, 030104 developmental biology, Infectious Diseases, Vietnam, Influenza in Birds, Parasitology, Female, Chickens
Abstract

Highly pathogenic avian influenza (HPAI) A(H5N1) viruses pose a significant economic burden to the poultry industry worldwide and have pandemic potential. Poultry vaccination against HPAI A(H5N1) viruses has been an important component of HPAI control measures and has been performed in Vietnam since 2005. To systematically assess antigenic matching of current vaccines to circulating field variants, we produced a panel of chicken and ferret antisera raised against historical and contemporary Vietnamese reference viruses representing clade variants that were detected between 2001 and 2014. The antisera were used for hemagglutination inhibition (HI) assays to generate data sets for analysis by antigenic cartography, allowing for a direct comparison of results from chicken or ferret antisera. HI antigenic maps, developed with antisera from both hosts, revealed varying patterns of antigenic relationships and clustering of viruses that were dependent on the clade of viruses analyzed. Antigenic relationships between existing poultry vaccines and circulating field viruses were also aligned with in vivo protection profiles determined by previously reported vaccine challenge studies. Our results establish the feasibility and utility of HPAI A(H5N1) antigenic characterization using chicken antisera and support further experimental and modeling studies to investigate quantitative relationships between genetic variation, antigenic drift and correlates of poultry vaccine protection in vivo.

Published
2018

21. Update: Increase in Human Infections with Novel Asian Lineage Avian Influenza A(H7N9) Viruses During the Fifth Epidemic - China, October 1, 2016-August 7, 2017.

Author

Kile JC, Ren R, Liu L, Greene CM, Roguski K, Iuliano AD, Jang Y, Jones J, Thor S, Song Y, Zhou S, Trock SC, Dugan V, Wentworth DE, Levine MZ, Uyeki TM, Katz JM, Jernigan DB, Olsen SJ, Fry AM, Azziz-Baumgartner E, and Davis CT

Subjects
Animals, China epidemiology, Humans, Influenza in Birds transmission, Influenza in Birds virology, Pandemics prevention & control, Poultry, Epidemics statistics & numerical data, Influenza A Virus, H7N9 Subtype isolation & purification, Influenza, Human epidemiology, Influenza, Human virology, Population Surveillance
Abstract

Among all influenza viruses assessed using CDC's Influenza Risk Assessment Tool (IRAT), the Asian lineage avian influenza A(H7N9) virus (Asian H7N9), first reported in China in March 2013,* is ranked as the influenza virus with the highest potential pandemic risk (1). During October 1, 2016-August 7, 2017, the National Health and Family Planning Commission of China; CDC, Taiwan; the Hong Kong Centre for Health Protection; and the Macao CDC reported 759 human infections with Asian H7N9 viruses, including 281 deaths, to the World Health Organization (WHO), making this the largest of the five epidemics of Asian H7N9 infections that have occurred since 2013 (Figure 1). This report summarizes new viral and epidemiologic features identified during the fifth epidemic of Asian H7N9 in China and summarizes ongoing measures to enhance pandemic preparedness. Infections in humans and poultry were reported from most areas of China, including provinces bordering other countries, indicating extensive, ongoing geographic spread. The risk to the general public is very low and most human infections were, and continue to be, associated with poultry exposure, especially at live bird markets in mainland China. Throughout the first four epidemics of Asian H7N9 infections, only low pathogenic avian influenza (LPAI) viruses were detected among human, poultry, and environmental specimens and samples. During the fifth epidemic, mutations were detected among some Asian H7N9 viruses, identifying the emergence of high pathogenic avian influenza (HPAI) viruses as well as viruses with reduced susceptibility to influenza antiviral medications recommended for treatment. Furthermore, the fifth-epidemic viruses diverged genetically into two separate lineages (Pearl River Delta lineage and Yangtze River Delta lineage), with Yangtze River Delta lineage viruses emerging as antigenically different compared with those from earlier epidemics. Because of its pandemic potential, candidate vaccine viruses (CVV) were produced in 2013 that have been used to make vaccines against Asian H7N9 viruses circulating at that time. CDC is working with partners to enhance surveillance for Asian H7N9 viruses in humans and poultry, to improve laboratory capability to detect and characterize H7N9 viruses, and to develop, test and distribute new CVV that could be used for vaccine production if a vaccine is needed.

Published
2017
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