1. Computed tomography-based pulmonary vasculature analysis of decreased lung perfusion after thoracic radiotherapy in patients with lung cancer.
- Author
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Huang, Yu-Sen, Chen, Jenny Ling-Yu, Ko, Wei-Chun, Lee, Yee-Fan, and Chang, Yeun-Chung
- Subjects
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NON-small-cell lung carcinoma , *LUNG volume , *BLOOD volume , *RADIATION doses , *OVERALL survival - Abstract
AbstractPurposeMaterials and methodsResultsConclusionsThis study aimed to quantitatively assess changes in lung perfusion after thoracic radiotherapy in lung cancer patients.Patients underwent chest computed tomography (CT) for pulmonary vasculature analysis before radiotherapy and at 3 and 12 months after radiotherapy. The correlation between the percentage decrease in lung perfusion after radiotherapy and the delivered radiotherapy dose was analyzed.The ipsilateral lung, where the primary tumor was located, received a significantly higher dose than the contralateral lung (mean dose: 22.9 Gy vs. 6.8 Gy). At 3 months, significant reductions in lung perfusion parameters were observed in the ipsilateral lung (total blood volume (TBV): 13.8%, blood volume in vessels with cross-sectional areas of ≤10 mm2: 12.6%, blood volume in vessels with cross-sectional areas of ≤5 mm2: 11.7%, subpleural vessel count: 21.1%, subpleural vessel area: 16.9%, and subpleural vessel density: 12.3%). Significant negative correlations between perfusion parameters and the radiation dose delivered to the ipsilateral lung were observed. For every 1-Gy increase in the mean dose for the ipsilateral lung, TBV decreased by 0.852% (
p = .044), and for every 1% increase in the percentage of lung volume that received more than 20 Gy, TBV decreased by 0.402% (p = .048). The 3-year overall survival of the patients was 75%. No significant association between baseline perfusion parameters and survival was observed.Thoracic radiotherapy significantly reduced pulmonary perfusion, especially in the ipsilateral lung. The reduction in perfusion correlated with the radiation dose. These findings underscore the impact of radiation-induced damage on perfusion. [ABSTRACT FROM AUTHOR]- Published
- 2024
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