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3. The feasibility of a multidimensional intervention in lymphoma survivors with chronic fatigue

Author

Bøhn, SKH, primary, Oldervoll, LM, additional, Reinertsen, KV, additional, Seland, M, additional, Fosså, A, additional, Kiserud, C, additional, Skaali, T, additional, Nilsen, TS, additional, Blomhoff, R, additional, Henriksen, HB, additional, Lie, HC, additional, Berge, T, additional, Fjerstad, E, additional, Wisløff, T, additional, Slott, M, additional, Zajmovic, I, additional, and Thorsen, L, additional

Published
2023
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4. Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses

Author

Bernard, P., Savard, J., Steindorf, K., Sweegers, M.G., Courneya, K.S., Newton, R.U., Aaronson, N.K., Jacobsen, P.B., May, A.M., Galvao, D.A., Chinapaw, M.J., Stuiver, M.M., Griffith, K.A., Mesters, I., Knoop, H., Goedendorp, M.M., Bohus, M., Thorsen, L., Schmidt, M.E., Ulrich, C.M., Sonke, G.S., van Harten, W., Winters-Stone, K.M., Velthuis, M.J., Taaffe, D.R., van Mechelen, W., Kersten, M.J., Nollet, F., Wenzel, J., Wiskemann, J., Verdonck-de Leeuw, I.M., Brug, J., and Buffart, L.M.

Published
2019
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7. Danish Breast Cancer Group Skagen Trial 1: A report on annual trial participation

Author

Thorsen, L. Bech Jellesmark, Mjaaland, I., Hjelstuen, M., Jakobsen, E. Hugger, Berg, M., Lörincz, T., Jensen, I., Kasti, U., Hasler, M., Nielsen, M. Holck, Lorentzen, E. Laugaard, Al-Rawi, S. Aziz-Jowad, Nielsen, M. M Bruun., Krause, M., Linge, A., Kamby, C., Boye, K., Yates, E. Svitzer, and Offersen, B. Vrou

Published
2022

8. PD-0740 Danish Breast Cancer Group Skagen Trial 1: A report on annual trial participation

Author

Bech Jellesmark Thorsen, L., primary, Mjaaland, I., additional, Hjelstuen, M., additional, Hugger Jakobsen, E., additional, Berg, M., additional, Lörincz, T., additional, Jensen, I., additional, Kasti, U., additional, Hasler, M., additional, Holck Nielsen, M., additional, Laugaard Lorentzen, E., additional, Aziz-Jowad Al-Rawi, S., additional, Bruun Nielsen, M.M., additional, Krause, M., additional, Linge, A., additional, Kamby, C., additional, Boye, K., additional, Svitzer Yates, E., additional, and Vrou Offersen, B., additional

Published
2022
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13. Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data.

Author

Vulpen, J.K. van, Sweegers, M.G., Peeters, P.H., Courneya, K.S., Newton, R.U., Aaronson, N.K., Jacobsen, P.B., Galvao, D.A., Chinapaw, M.J., Steindorf, K., Irwin, M.L., Stuiver, M.M., Hayes, S., Griffith, K.A., Mesters, I., Knoop, H., Goedendorp, M.M., Mutrie, N., Daley, A.J., McConnachie, A., Bohus, M., Thorsen, L., Schulz, K.H., Short, C.E., James, E.L., Plotnikoff, R.C., Schmidt, M.E., Ulrich, C.M., Beurden, M. van, Oldenburg, H.S., Sonke, G.S., Harten, W.H. van, Schmitz, K.H., Winters-Stone, K.M., Velthuis, M.J., Taaffe, D.R., Mechelen, W. van, Kersten, M.J., Nollet, F., Wenzel, J., Wiskemann, J., Verdonck-de Leeuw, I.M., Brug, J., May, A.M., Buffart, L.M., Vulpen, J.K. van, Sweegers, M.G., Peeters, P.H., Courneya, K.S., Newton, R.U., Aaronson, N.K., Jacobsen, P.B., Galvao, D.A., Chinapaw, M.J., Steindorf, K., Irwin, M.L., Stuiver, M.M., Hayes, S., Griffith, K.A., Mesters, I., Knoop, H., Goedendorp, M.M., Mutrie, N., Daley, A.J., McConnachie, A., Bohus, M., Thorsen, L., Schulz, K.H., Short, C.E., James, E.L., Plotnikoff, R.C., Schmidt, M.E., Ulrich, C.M., Beurden, M. van, Oldenburg, H.S., Sonke, G.S., Harten, W.H. van, Schmitz, K.H., Winters-Stone, K.M., Velthuis, M.J., Taaffe, D.R., Mechelen, W. van, Kersten, M.J., Nollet, F., Wenzel, J., Wiskemann, J., Verdonck-de Leeuw, I.M., Brug, J., May, A.M., and Buffart, L.M.

Abstract

01 februari 2020, Contains fulltext : 220990.pdf (Publisher’s version ) (Closed access), PURPOSE: Fatigue is a common and potentially disabling symptom in patients with cancer. It can often be effectively reduced by exercise. Yet, effects of exercise interventions might differ across subgroups. We conducted a meta-analysis using individual patient data of randomized controlled trials (RCT) to investigate moderators of exercise intervention effects on cancer-related fatigue. METHODS: We used individual patient data from 31 exercise RCT worldwide, representing 4366 patients, of whom 3846 had complete fatigue data. We performed a one-step individual patient data meta-analysis, using linear mixed-effect models to analyze the effects of exercise interventions on fatigue (z score) and to identify demographic, clinical, intervention- and exercise-related moderators. Models were adjusted for baseline fatigue and included a random intercept on study level to account for clustering of patients within studies. We identified potential moderators by testing their interaction with group allocation, using a likelihood ratio test. RESULTS: Exercise interventions had statistically significant beneficial effects on fatigue (beta = -0.17; 95% confidence interval [CI], -0.22 to -0.12). There was no evidence of moderation by demographic or clinical characteristics. Supervised exercise interventions had significantly larger effects on fatigue than unsupervised exercise interventions (betadifference = -0.18; 95% CI -0.28 to -0.08). Supervised interventions with a duration

Published
2020

17. Effects and moderators of exercise on sleep in adults with cancer : Individual patient data and aggregated meta-analyses

Author

Bernard, P, Savard, J, Steindorf, K, Sweegers, M G, Courneya, K S, Newton, R U, Aaronson, N K, Jacobsen, P B, May, A M, Galvao, D A, Chinapaw, M J, Stuiver, M M, Griffith, K A, Mesters, I, Knoop, H, Goedendorp, M M, Bohus, M, Thorsen, L, Schmidt, M E, Ulrich, C M, Sonke, G S, van Harten, W, Winters-Stone, K M, Velthuis, M J, Taaffe, D R, van Mechelen, W, Kersten, M J, Nollet, F, Wenzel, J, Wiskemann, J, Verdonck-de Leeuw, I M, Brug, J, Buffart, L M, Bernard, P, Savard, J, Steindorf, K, Sweegers, M G, Courneya, K S, Newton, R U, Aaronson, N K, Jacobsen, P B, May, A M, Galvao, D A, Chinapaw, M J, Stuiver, M M, Griffith, K A, Mesters, I, Knoop, H, Goedendorp, M M, Bohus, M, Thorsen, L, Schmidt, M E, Ulrich, C M, Sonke, G S, van Harten, W, Winters-Stone, K M, Velthuis, M J, Taaffe, D R, van Mechelen, W, Kersten, M J, Nollet, F, Wenzel, J, Wiskemann, J, Verdonck-de Leeuw, I M, Brug, J, and Buffart, L M

Published
2019

18. Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses

Author

Bernard, P. A., Savard, J., Steindorf, K., Sweegers, M. G., Courneya, K. S., Newton, R. U., Aaronson, N. K., Jacobsen, P. B., May, A. M., Galvao, D. A., Chinapaw, M. J., Stuiver, M. M., Griffith, K. A., Mesters, I, Knoop, H., Goedendorp, M. M., Bohus, M., Thorsen, L., Schmidt, M. E., Ulrich, C. M., Sonke, G. S., van Harten, W., Winters-Stone, K. M., Velthuis, M. J., Taaffe, D. R., van Mechelen, W., Kersten, M. J., Nollet, F., Wenzel, J., Wiskemann, J., Verdonck-de Leeuw, I. M., Brug, J., Buffart, L. M., Bernard, P. A., Savard, J., Steindorf, K., Sweegers, M. G., Courneya, K. S., Newton, R. U., Aaronson, N. K., Jacobsen, P. B., May, A. M., Galvao, D. A., Chinapaw, M. J., Stuiver, M. M., Griffith, K. A., Mesters, I, Knoop, H., Goedendorp, M. M., Bohus, M., Thorsen, L., Schmidt, M. E., Ulrich, C. M., Sonke, G. S., van Harten, W., Winters-Stone, K. M., Velthuis, M. J., Taaffe, D. R., van Mechelen, W., Kersten, M. J., Nollet, F., Wenzel, J., Wiskemann, J., Verdonck-de Leeuw, I. M., Brug, J., and Buffart, L. M.

Abstract

Objectives: To evaluate the effects of exercise interventions on sleep disturbances and sleep quality in patients with mixed cancer diagnoses, and identify demographic, clinical, and intervention-related moderators of these effects. Methods: Individual patient data (IPD) and aggregated meta-analyses of randomized controlled trials (RCTs). Using data from the Predicting OptimaL cAncer RehabIlitation and Supportive care project, IPD of 2173 adults (mean age = 54.8) with cancer from 17 RCTs were analyzed. A complementary systematic search was conducted (until November 2018) to study the overall effects and test the representativeness of analyzed IPD. Effect sizes of exercise effects on self-reported sleep outcomes were calculated for all included RCTs. Linear mixed-effect models were used to evaluate the effects of exercise on post-intervention outcome values, adjusting for baseline values. Moderator effects were studied by testing interactions for demographic, clinical and intervention-related characteristics. Results: For all 27 eligible RCTs from the updated search, exercise interventions significantly decreased sleep disturbances in adults with cancer (g = −0.09, 95% CI [−0.16; −0.02]). No significant effect was obtained for sleep quality. RCTs included in IPD analyses constituted a representative sample of the published literature. The intervention effects on sleep disturbances were not significantly moderated by any demographic, clinical, or intervention-related factor, nor by sleep disturbances. Conclusions: This meta-analysis provides some evidence that, compared to control conditions, exercise interventions may improve sleep disturbances, but not sleep quality, in cancer patients, although this effect is of a small magnitude. Among the investigated variables, none was found to significantly moderate the effect of exercise interventions on sleep disturbances.

Published
2019
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19. Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses

Author

JC onderzoeksprogramma Kanker, Cancer, Epidemiology & Health Economics, Epi Kanker Team 1, Bernard, P, Savard, J, Steindorf, K, Sweegers, M G, Courneya, K S, Newton, R U, Aaronson, N K, Jacobsen, P B, May, A M, Galvao, D A, Chinapaw, M J, Stuiver, M M, Griffith, K A, Mesters, I, Knoop, H, Goedendorp, M M, Bohus, M, Thorsen, L, Schmidt, M E, Ulrich, C M, Sonke, G S, van Harten, W, Winters-Stone, K M, Velthuis, M J, Taaffe, D R, van Mechelen, W, Kersten, M J, Nollet, F, Wenzel, J, Wiskemann, J, Verdonck-de Leeuw, I M, Brug, J, Buffart, L M, JC onderzoeksprogramma Kanker, Cancer, Epidemiology & Health Economics, Epi Kanker Team 1, Bernard, P, Savard, J, Steindorf, K, Sweegers, M G, Courneya, K S, Newton, R U, Aaronson, N K, Jacobsen, P B, May, A M, Galvao, D A, Chinapaw, M J, Stuiver, M M, Griffith, K A, Mesters, I, Knoop, H, Goedendorp, M M, Bohus, M, Thorsen, L, Schmidt, M E, Ulrich, C M, Sonke, G S, van Harten, W, Winters-Stone, K M, Velthuis, M J, Taaffe, D R, van Mechelen, W, Kersten, M J, Nollet, F, Wenzel, J, Wiskemann, J, Verdonck-de Leeuw, I M, Brug, J, and Buffart, L M

Published
2019

21. Targeting Exercise Interventions to Patients With Cancer in Need: An Individual Patient Data Meta-Analysis

Author

Buffart, L.M., Sweegers, M.G., May, A.M., Chinapaw, M.J., Vulpen, J.K. van, Newton, R.U., Galvao, D.A., Aaronson, N.K., Stuiver, M.M., Jacobsen, P.B., Verdonck-de Leeuw, I.M., Steindorf, K., Irwin, M.L., Hayes, S., Griffith, K.A., Lucia, A., Herrero-Roman, F., Mesters, I., Weert, E. Van, Knoop, H., Goedendorp, M.M., Mutrie, N., Daley, A.J., McConnachie, A., Bohus, M., Thorsen, L., Schulz, K.H., Short, C.E., James, E.L., Plotnikoff, R.C., Arbane, G., Schmidt, M.E., Potthoff, K., Beurden, M. van, Oldenburg, H.S., Sonke, G.S., Harten, W.H. van, Garrod, R., Schmitz, K.H., Winters-Stone, K.M., Velthuis, M.J., Taaffe, D.R., Mechelen, W. van, Kersten, M., Nollet, F., Wenzel, J., Wiskemann, J., Brug, J., Courneya, K.S., Buffart, L.M., Sweegers, M.G., May, A.M., Chinapaw, M.J., Vulpen, J.K. van, Newton, R.U., Galvao, D.A., Aaronson, N.K., Stuiver, M.M., Jacobsen, P.B., Verdonck-de Leeuw, I.M., Steindorf, K., Irwin, M.L., Hayes, S., Griffith, K.A., Lucia, A., Herrero-Roman, F., Mesters, I., Weert, E. Van, Knoop, H., Goedendorp, M.M., Mutrie, N., Daley, A.J., McConnachie, A., Bohus, M., Thorsen, L., Schulz, K.H., Short, C.E., James, E.L., Plotnikoff, R.C., Arbane, G., Schmidt, M.E., Potthoff, K., Beurden, M. van, Oldenburg, H.S., Sonke, G.S., Harten, W.H. van, Garrod, R., Schmitz, K.H., Winters-Stone, K.M., Velthuis, M.J., Taaffe, D.R., Mechelen, W. van, Kersten, M., Nollet, F., Wenzel, J., Wiskemann, J., Brug, J., and Courneya, K.S.

Abstract

Item does not contain fulltext, Background: Exercise effects in cancer patients often appear modest, possibly because interventions rarely target patients most in need. This study investigated the moderator effects of baseline values on the exercise outcomes of fatigue, aerobic fitness, muscle strength, quality of life (QoL), and self-reported physical function (PF) in cancer patients during and post-treatment. Methods: Individual patient data from 34 randomized exercise trials (n = 4519) were pooled. Linear mixed-effect models were used to study moderator effects of baseline values on exercise intervention outcomes and to determine whether these moderator effects differed by intervention timing (during vs post-treatment). All statistical tests were two-sided. Results: Moderator effects of baseline fatigue and PF were consistent across intervention timing, with greater effects in patients with worse fatigue (Pinteraction = .05) and worse PF (Pinteraction = .003). Moderator effects of baseline aerobic fitness, muscle strength, and QoL differed by intervention timing. During treatment, effects on aerobic fitness were greater for patients with better baseline aerobic fitness (Pinteraction = .002). Post-treatment, effects on upper (Pinteraction < .001) and lower (Pinteraction = .01) body muscle strength and QoL (Pinteraction < .001) were greater in patients with worse baseline values. Conclusion: Although exercise should be encouraged for most cancer patients during and post-treatments, targeting specific subgroups may be especially beneficial and cost effective. For fatigue and PF, interventions during and post-treatment should target patients with high fatigue and low PF. During treatment, patients experience benefit for muscle strength and QoL regardless of baseline values; however, only patients with low baseline values benefit post-treatment. For aerobic fitness, patients with low baseline values do not appear to benefit from exercise during treatment.

Published
2018

22. Abstract P6-12-06: Effect and moderators of exercise on fatigue in patients with breast cancer: Meta-analysis of individual patient data

Author

van Vulpen, JK, primary, Sweegers, MG, additional, Kalter, J, additional, Peeters, PH, additional, Courneya, KS, additional, Newton, RU, additional, Aaronson, NK, additional, Jacobsen, PB, additional, Steindorf, K, additional, Stuiver, MM, additional, Hayes, S, additional, Mesters, I, additional, Knoop, H, additional, Goedendorp, M, additional, Mutrie, N, additional, Thorsen, L, additional, Schmidt, M, additional, Sonke, GS, additional, Bohus, M, additional, James, EL, additional, Oldenburg, HS, additional, Velthuis, MJ, additional, Nollet, F, additional, Wenzel, J, additional, Wiskemann, J, additional, Galvão, DA, additional, Chinapaw, MJ, additional, Irwin, ML, additional, Griffith, KA, additional, van Weert, E, additional, Daley, AJ, additional, McConnachie, A, additional, Schulz, K-H, additional, Short, CE, additional, Plotnikoff, RC, additional, Potthoff, K, additional, van Beurden, M, additional, van Harten, WH, additional, Schmitz, KH, additional, Winters-Stone, KM, additional, Taaffe, DR, additional, van Mechelen, W, additional, Kersten, M-J, additional, Verdonck-de Leeuw, IM, additional, Brug, J, additional, Buffart, LM, additional, and May, AM, additional

Published
2018
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23. Effects and moderators of exercise on quality of life and physical function in patients with cancer: An individual patient data meta-analysis of 34 RCTs

Author

Buffart, L.M., Kalter, J., Sweegers, M.G., Courneya, K.S., Newton, R.U., Aaronson, N.K., Jacobsen, P.B., May, A.M., Galvao, D.A., Chinapaw, M.J., Steindorf, K., Irwin, M.L., Stuiver, M.M., Hayes, S., Griffith, K.A., Lucia, A., Mesters, I., Weert, E. Van, Knoop, H., Goedendorp, M.M., Mutrie, N., Daley, A.J., McConnachie, A., Bohus, M., Thorsen, L., Schulz, K.H., Short, C.E., James, E.L., Plotnikoff, R.C., Arbane, G., Schmidt, M.E., Potthoff, K., Beurden, M. van, Oldenburg, H.S., Sonke, G.S., Harten, W.H. van, Garrod, R., Schmitz, K.H., Winters-Stone, K.M., Velthuis, M.J., Taaffe, D.R., Mechelen, W. van, Kersten, M.J., Nollet, F., Wenzel, J., Wiskemann, J., Verdonck-de Leeuw, I.M., Brug, J., Buffart, L.M., Kalter, J., Sweegers, M.G., Courneya, K.S., Newton, R.U., Aaronson, N.K., Jacobsen, P.B., May, A.M., Galvao, D.A., Chinapaw, M.J., Steindorf, K., Irwin, M.L., Stuiver, M.M., Hayes, S., Griffith, K.A., Lucia, A., Mesters, I., Weert, E. Van, Knoop, H., Goedendorp, M.M., Mutrie, N., Daley, A.J., McConnachie, A., Bohus, M., Thorsen, L., Schulz, K.H., Short, C.E., James, E.L., Plotnikoff, R.C., Arbane, G., Schmidt, M.E., Potthoff, K., Beurden, M. van, Oldenburg, H.S., Sonke, G.S., Harten, W.H. van, Garrod, R., Schmitz, K.H., Winters-Stone, K.M., Velthuis, M.J., Taaffe, D.R., Mechelen, W. van, Kersten, M.J., Nollet, F., Wenzel, J., Wiskemann, J., Verdonck-de Leeuw, I.M., and Brug, J.

Abstract

Contains fulltext : 170325.pdf (Publisher’s version ) (Open Access), This individual patient data meta-analysis aimed to evaluate the effects of exercise on quality of life (QoL) and physical function (PF) in patients with cancer, and to identify moderator effects of demographic (age, sex, marital status, education), clinical (body mass index, cancer type, presence of metastasis), intervention-related (intervention timing, delivery mode and duration, and type of control group), and exercise-related (exercise frequency, intensity, type, time) characteristics. Relevant published and unpublished studies were identified in September 2012 via PubMed, EMBASE, PsycINFO, and CINAHL, reference checking and personal communications. Principle investigators of all 69 eligible trials were requested to share IPD from their study. IPD from 34 randomised controlled trials (n=4519 patients) that evaluated the effects of exercise compared to a usual care, wait-list or attention control group on QoL and PF in adult patients with cancer were retrieved and pooled. Linear mixed-effect models were used to evaluate the effects of the exercise on post-intervention outcome values (z-score) adjusting for baseline values. Moderator effects were studies by testing interactions. Exercise significantly improved QoL (beta=0.15, 95%CI=0.10;0.20) and PF (beta=0.18, 95%CI=0.13;0.23). The effects were not moderated by demographic, clinical or exercise characteristics. Effects on QoL (betadifference_in_effect=0.13, 95%CI=0.03;0.22) and PF (betadifference_in_effect=0.10, 95%CI=0.01;0.20) were significantly larger for supervised than unsupervised interventions. In conclusion, exercise, and particularly supervised exercise, effectively improves QoL and PF in patients with cancer with different demographic and clinical characteristics during and following treatment. Although effect sizes are small, there is consistent empirical evidence to support implementation of exercise as part of cancer care.

Published
2017

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Author

Mecarocci, V., primary, Mapelli, M., primary, Johnson, K., primary, Kamperidis, V., primary, Treede, H., primary, Alonso Fernandez De Gatta, M., primary, Mameri, A., primary, Pressman, G., primary, Coutinho Cruz, M., primary, Bartolacelli, Y., primary, Gillebert, C., primary, Lozano-Granero, VC., primary, Boretti, I., primary, Son, JW., primary, Carvalho, JF., primary, Zuo, L., primary, Basu, J., primary, Gomes, AC., primary, Lie, OH., primary, Aleksandrov, AS., primary, Tang, HC., primary, Alvi, N., primary, Marek, J., primary, Rascon Sabido, R., primary, Mori, F., additional, Fusini, L., additional, Zagni, P., additional, Muratori, M., additional, Agostoni, P., additional, Gripari, P., additional, Ghulam Ali, S., additional, Tamborini, G., additional, Pepi, M., additional, Fiorentini, C., additional, Abdel-Rahman, ST., additional, Dobson, L., additional, Kidambi, A., additional, Gatenby, K., additional, Schlosshan, D., additional, Van Wijngaarden, SE., additional, Van Rosendael, PJ., additional, Kong Kok Fai, W., additional, Leung, M., additional, Sianos, G., additional, Ajmone Marsan, N., additional, Bax, JJ., additional, Delgado, V., additional, Nickenig, G., additional, Kuck, KH., additional, Baldus, S., additional, Vahanian, A., additional, Colombo, A., additional, Alfieri, O., additional, Topilsky, Y., additional, Grayburn, P., additional, Maisano, F., additional, Barreiro Perez, M., additional, Arribas Jimenez, A., additional, Martin Garcia, A., additional, Diaz Pelaez, E., additional, Rodriguez Collado, J., additional, Cruz Gonzalez, I., additional, Sanchez Fernandez, PL., additional, Urena Alcazar, M., additional, Cimadevilla, C., additional, Himbert, D., additional, Raffoul, R., additional, Verdonk, C., additional, Nataf, P., additional, Messika-Zeitoun, D., additional, Gartman, CH., additional, Obasare, E., additional, Melendres, E., additional, Malik, M., additional, Slipczuk, L., additional, Figueredo, V., additional, Ilhao Moreira, R., additional, Moura Branco, L., additional, Galrinho, A., additional, Coutinho Miranda, L., additional, Timoteo, AT., additional, Abreu, J., additional, Pinto Teixeira, P., additional, Fragata, J., additional, Cruz Ferreira, R., additional, Barbieri, A., additional, Bursi, F., additional, Mantovani, F., additional, Lugli, R., additional, Fabbri, M., additional, Mussini, C., additional, Boriani, G., additional, Perry, R., additional, Hecker, T., additional, Szpytma, M., additional, Joseph, M., additional, Fernandez-Santos, S., additional, Plaza-Martin, M., additional, Lopez-Fernandez, T., additional, De La Hera, JM., additional, Martinez-Monzonis, A., additional, La Canna, G., additional, Mesa, D., additional, Swaans, M., additional, Murzilli, R., additional, Echevarria, T., additional, Habib, G., additional, Zamorano, JL., additional, Fernandez-Golfin Loban, C., additional, Salido, L., additional, Gonzalez Gomez, A., additional, Garcia Martin, A., additional, Hinojar Baides, R., additional, Pardo, A., additional, Moya Mur, JL., additional, Ruiz Leria, S., additional, Hernandez Antolin, R., additional, Jimenez Nacher, JJ., additional, Zamorano Gomez, JL., additional, Kim, HJ., additional, Kim, BJ., additional, Choi, KW., additional, Lee, CH., additional, Kim, W., additional, Park, JS., additional, Shin, DG., additional, Kim, YJ., additional, Choi, JH., additional, Congo, K., additional, Neves, D., additional, Pais, J., additional, Guerreiro, R., additional, Picarra, B., additional, Santos, AR., additional, Bento, A., additional, Aguiar, J., additional, Wang, J., additional, Ta, SJ., additional, Kang, N., additional, Zhou, MY., additional, Guo, RQ., additional, Liu, L., additional, Thorsen, L., additional, Thomas, K., additional, Shabbir, A., additional, Balkhausen, K., additional, Bull, S., additional, Lopes, LR., additional, Cruz, I., additional, Almeida, AR., additional, Pereira, H., additional, Saberniak, J., additional, Dejgaard, LA., additional, Anfinsen, OG., additional, Hegbom, F., additional, Edvardsen, T., additional, Haugaa, KH., additional, Kasner, M., additional, Tschoepe, C., additional, Ho, JS., additional, Goh, LK., additional, Ding, ZP., additional, Tipoo, FA., additional, Chowdhury, D., additional, Colan, S., additional, Imran, A., additional, Raza, U., additional, Ashiqali, S., additional, Hasan, BS., additional, Mohty, D., additional, Palecek, T., additional, Golan, L., additional, Jaccard, A., additional, Lenhart, A., additional, Garcia Mendez Rosalba, RGM, additional, Martinez Hernandez Carlos, MHC, additional, Ibarra Quevedo David, DIQ, additional, and Almeida Gutierrez Eduardo, EAG, additional

Published
2016
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31. Effects of strength training on muscle cellular outcomes in prostate cancer patients on androgen deprivation therapy.

Author

Nilsen, T. S., Thorsen, L., Fosså, S. D., Wiig, M., Kirkegaard, C., Skovlund, E., Benestad, H. B., and Raastad, T.

Subjects
*MUSCLE anatomy, *ANALYSIS of covariance, *BIOPSY, *CELL receptors, *CONFIDENCE intervals, *HORMONE therapy, *IMMUNOHISTOCHEMISTRY, *LONGITUDINAL method, *MUSCLE strength, *PROBABILITY theory, *PROSTATE tumors, *RESEARCH funding, *T-test (Statistics), *WESTERN immunoblotting, *STATISTICAL power analysis, *EFFECT sizes (Statistics), *DATA analysis software, *SKELETAL muscle, *MYOSTATIN, *RESISTANCE training
Abstract

Androgen deprivation therapy ( ADT) improves life expectancy in prostate cancer ( PCa) patients, but is associated with adverse effects on muscle mass. Here, we investigated the effects of strength training during ADT on muscle fiber cross-sectional area ( CSA) and regulators of muscle mass. PCa patients on ADT were randomized to 16 weeks of strength training ( STG) ( n = 12) or a control group ( CG; n = 11). Muscle biopsies were obtained from m. vastus lateralis and analyzed by immunohistochemistry and western blot. Muscle fiber CSA increased with strength training (898 μm2, P = 0.04), with the only significant increase observed in type II fibers (1076 μm2, P = 0.03). There was a trend toward a difference in mean change between groups myonuclei number (0.33 nuclei/fiber, P = 0.06), with the only significant increase observed in type I fibers, which decreased the myonuclear domain size of type I fibers ( P = 0.05). Satellite cell numbers and the content of androgen receptor and myostatin remained unchanged. Sixteen weeks of strength training during ADT increased type II fiber CSA and reduced myonuclear domain in type I fibers in PCa patients. The increased number of satellite cells normally seen following strength training was not observed. [ABSTRACT FROM AUTHOR]

Published
2016
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36. Exercise behavior in cancer survivors and associated factors.

Author

Gjerset GM, Fosså SD, Courneya KS, Skovlund E, Thorsen L, Gjerset, Gunhild Maria, Fosså, Sophie Dorothea, Courneya, Kerry S, Skovlund, Eva, and Thorsen, Lene

Abstract

Introduction: Physical activity is an important component in promoting a healthy life style in cancer survivors. We estimated the proportion of cancer survivors who are physically active, defined as meeting public health exercise guidelines, and changes in level of physical activity (LPA) from before diagnosis to after treatment. We also identified medical and demographic factors associated with LPA and its changes.Methods: A cross-sectional survey assessing LPA before diagnosis and after treatment, together with demographic and medical variables in 975 cancer survivors.Results: Forty-five percent of the cancer survivors were physically active after treatment. Before diagnosis and after treatment 33% were active, whereas 40% were inactive at both time points. Fifteen percent were active before diagnosis but inactive after treatment, and 12% were inactive before diagnosis but active after treatment. Increasing age and weight, low education, comorbidity and smoking were associated with physical inactivity after treatment. Change in LPA from active to inactive was associated with comorbidity, distant disease and smoking, while a change from inactive to active was associated with high education.Conclusions: Less than half of cancer survivors were physically active. Almost three quarters of cancer survivors remained stable in LPA. The remaining quarter changed LPA, with slightly more cancer survivors becoming inactive than active. Age, weight, education, comorbidity, disease stage and smoking can identify survivors at risk of physical inactivity after treatment.Implications For Cancer Survivors: Recognizable variables can be used to identify physically inactive cancer survivors after treatment and give these survivors support to start or maintain LPA. [ABSTRACT FROM AUTHOR]

Published
2011
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38. A systematic review of physical activity in prostate cancer survivors: outcomes, prevalence, and determinants.

Author

Thorsen L, Courneya KS, Stevinson C, Fosså SD, Thorsen, Lene, Courneya, Kerry S, Stevinson, Clare, and Fosså, Sophie D

Abstract

Introduction: We reviewed physical activity (PA) studies in prostate cancer (PC) survivors investigating (a) the effects of PA on health outcomes, (b) the prevalence of PA, and (c) the determinants of PA.Materials and Methods: A systematic search of the literature identified nine studies on the outcomes of PA, six studies on the prevalence of PA, and four studies on the determinants of PA in PC survivors.Results: Results showed promising effects of PA on muscular fitness, physical functioning, fatigue, and health-related quality of life. The prevalence of PA varied widely from <30% to >70%, depending on the type of measure used. PA in PC survivors was predicted by motivational variables such as intentions, perceived behavioral control, and subjective norms.Conclusion: Although preliminary research is promising, there remains a significant amount of research to be done on the role of PA in PC survivors. Moreover, future research would benefit from larger samples using randomized controlled trial methodology. [ABSTRACT FROM AUTHOR]

Published
2008
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42. Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses

Author

Bernard, P., Savard, J., Steindorf, K., Sweegers, M. G., Courneya, K. S., Newton, Robert U., Aaronson, N. K., Jacobsen, P. B., May, A. M., Galvao, Daniel A., Chinapaw, M. J., Stuiver, M. M., Griffith, K. A., Mesters, I., Knoop, H., Goedendorp, M. M., Bohus, M., Thorsen, L., Schmidt, M. E., Ulrich, C. M., Sonke, G. S., van Harten, W., Winters-Stone, K. M., Velthuis, M. J., Taaffe, D. R., van Mechelen, W., Kersten, M. J., Nollet, F., Wenzel, J., Wiskemann, J., Verdonck-de Leeuw, I. M., Brug, J., Buffart, L. M., Bernard, P., Savard, J., Steindorf, K., Sweegers, M. G., Courneya, K. S., Newton, Robert U., Aaronson, N. K., Jacobsen, P. B., May, A. M., Galvao, Daniel A., Chinapaw, M. J., Stuiver, M. M., Griffith, K. A., Mesters, I., Knoop, H., Goedendorp, M. M., Bohus, M., Thorsen, L., Schmidt, M. E., Ulrich, C. M., Sonke, G. S., van Harten, W., Winters-Stone, K. M., Velthuis, M. J., Taaffe, D. R., van Mechelen, W., Kersten, M. J., Nollet, F., Wenzel, J., Wiskemann, J., Verdonck-de Leeuw, I. M., Brug, J., and Buffart, L. M.

Abstract

Bernard, P., Savard, J., Steindorf, K., Sweegers, M. G., Courneya, K. S., Newton, R. U., ... Buffart, L. M., (2019). Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses. Journal of Psychosomatic Research, 124, Article 109746. Available here

43. Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses

Author

Bernard, P., Savard, J., Steindorf, K., Sweegers, M.G., Courneya, K.S., Newton, R.U., Aaronson, N.K., Jacobsen, P.B., May, A.M., Galvao, D.A., Chinapaw, M.J., Stuiver, M.M., Griffith, K.A., Mesters, I., Knoop, H., Goedendorp, M.M., Bohus, M., Thorsen, L., Schmidt, M.E., Ulrich, C.M., Sonke, G.S., van Harten, W., Winters-Stone, K.M., Velthuis, M.J., Taaffe, D.R., van Mechelen, W., Kersten, M.J., Nollet, F., Wenzel, J., Wiskemann, J., Verdonck-de Leeuw, I.M., Brug, J., Buffart, L.M., Bernard, P., Savard, J., Steindorf, K., Sweegers, M.G., Courneya, K.S., Newton, R.U., Aaronson, N.K., Jacobsen, P.B., May, A.M., Galvao, D.A., Chinapaw, M.J., Stuiver, M.M., Griffith, K.A., Mesters, I., Knoop, H., Goedendorp, M.M., Bohus, M., Thorsen, L., Schmidt, M.E., Ulrich, C.M., Sonke, G.S., van Harten, W., Winters-Stone, K.M., Velthuis, M.J., Taaffe, D.R., van Mechelen, W., Kersten, M.J., Nollet, F., Wenzel, J., Wiskemann, J., Verdonck-de Leeuw, I.M., Brug, J., and Buffart, L.M.

47. A randomized controlled trial on the effectiveness of strength training on clinical and muscle cellular outcomes in patients with prostate cancer during androgen deprivation therapy: rationale and design

Author

Thorsen Lene, Nilsen Tormod S, Raastad Truls, Courneya Kerry S, Skovlund Eva, and Fosså Sophie D

Subjects
Strength training, Prostate cancer, Androgen deprivation therapy, Clinical and muscle cellular outcomes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Studies indicate that strength training has beneficial effects on clinical health outcomes in prostate cancer patients during androgen deprivation therapy. However, randomized controlled trials are needed to scientifically determine the effectiveness of strength training on the muscle cell level. Furthermore, close examination of the feasibility of a high-load strength training program is warranted. The Physical Exercise and Prostate Cancer (PEPC) trial is designed to determine the effectiveness of strength training on clinical and muscle cellular outcomes in non-metastatic prostate cancer patients after high-dose radiotherapy and during ongoing androgen deprivation therapy. Methods/design Patients receiving androgen deprivation therapy for 9-36 months combined with external high-dose radiotherapy for locally advanced prostate cancer are randomized to an exercise intervention group that receives a 16 week high-load strength training program or a control group that is encouraged to maintain their habitual activity level. In both arms, androgen deprivation therapy is continued until the end of the intervention period. Clinical outcomes are body composition (lean body mass, bone mineral density and fat mass) measured by Dual-energy X-ray Absorptiometry, serological outcomes, physical functioning (muscle strength and cardio-respiratory fitness) assessed with physical tests and psycho-social functioning (mental health, fatigue and health-related quality of life) assessed by questionnaires. Muscle cellular outcomes are a) muscle fiber size b) regulators of muscle fiber size (number of myonuclei per muscle fiber, number of satellite cells per muscle fiber, number of satellite cells and myonuclei positive for androgen receptors and proteins involved in muscle protein degradation and muscle hypertrophy) and c) regulators of muscle fiber function such as proteins involved in cellular stress and mitochondrial function. Muscle cellular outcomes are measured on muscle cross sections and muscle homogenate from muscle biopsies obtained from muscle vastus lateralis. Discussion The findings from the PEPC trial will provide new knowledge on the effects of high-load strength training on clinical and muscle cellular outcomes in prostate cancer patients during androgen deprivation therapy. Trial registration ClinicalTrials.gov: NCT00658229

Published
2012
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48. Physical activity in Hodgkin's lymphoma survivors with and without chronic fatigue compared with the general population – a cross-sectional study

Author

Thorsen Lene, Hjermstad Marianne J, Lydersen Stian, Kaasa Stein, Loge Jon H, Oldervoll Line M, Holte Harald, Jacobsen Anne B, and Fosså Sophie D

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Hodgkin's lymphoma survivors (HLSs) commonly report chronic fatigue, defined as high levels of fatigue for 6 months or more. Underlying mechanisms are poorly understood. Based upon knowledge from other populations, lifestyle parameters may be related to this increased and persistent fatigue. The primary objective of the present study was to assess self-reported levels of physical activity, smoking habits and sleep patterns in HLSs with and without chronic fatigue. The secondary objective was to compare these results with data from age and gender adjusted data from the general population (Gen-Pop). Methods The Fatigue Questionnaire (FQ) and questions about daily smoking, sleep patterns and level of physical activity were completed by 476 HLSs treated at Rikshospitalet-Radiumhospitalet Trust (RR). The Gen-Pop data was derived from 56.999 inhabitants in a Norwegian county responding to a mail survey. Fischer's exact test, chi square test and t-tests were used to compare groups. P-values < .05 were considered statistically significant. A logistic regression analysis was performed in comparing the Gen-Pop with the HLSs. Results Level of physical activity, smoking habits and sleep patterns did not differ significantly between HLSs with and without chronic fatigue. The multivariate logistic regression analysis adjusting for different covariates, showed significantly more physically active men among HLSs compared with the Gen-Pop (OR = 1.50, CI 1.04 – 2.17), p = .031. No significant difference was found among females (OR = 1.20, CI = 0.83 – 1.74), p = .33. Conclusion Lifestyle parameters did not seem to be related to increased and persistent fatigue among HLSs. The results may indicate that the experience of Hodgkin's lymphoma increases the level of physical activity among male HLSs.

Published
2007
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