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726 results on '"Thuret G"'

16. Approaches for corneal endothelium regenerative medicine

Author

Català, P., Thuret, G., Skottman, H., Mehta, J.S., Parekh, M., S, N.D., Collin, R.W.J., Nuijts, R., Ferrari, S., LaPointe, V.L.S., Dickman, M.M., Català, P., Thuret, G., Skottman, H., Mehta, J.S., Parekh, M., S, N.D., Collin, R.W.J., Nuijts, R., Ferrari, S., LaPointe, V.L.S., and Dickman, M.M.

Abstract

Item does not contain fulltext, The state of the art therapy for treating corneal endothelial disease is transplantation. Advances in the reproducibility and accessibility of surgical techniques are increasing the number of corneal transplants, thereby causing a global deficit of donor corneas and leaving 12.7 million patients with addressable visual impairment. Approaches to regenerate the corneal endothelium offer a solution to the current tissue scarcity and a treatment to those in need. Methods for generating corneal endothelial cells into numbers that could address the current tissue shortage and the possible strategies used to deliver them have now become a therapeutic reality with clinical trials taking place in Japan, Singapore and Mexico. Nevertheless, there is still a long way before such therapies are approved by regulatory bodies and become clinical practice. Moreover, acellular corneal endothelial graft equivalents and certain drugs could provide a treatment option for specific disease conditions without the need of donor tissue or cells. Finally, with the emergence of gene modulation therapies to treat corneal endothelial disease, it would be possible to treat presymptomatic patients or those presenting early symptoms, drastically reducing the need for donor tissue. It is necessary to understand the most recent developments in this rapidly evolving field to know which conditions could be treated with which approach. This article provides an overview of the current and developing regenerative medicine therapies to treat corneal endothelial disease and provides the necessary guidance and understanding towards the treatment of corneal endothelial disease.

Published
2022

33. Is manual counting of corneal endothelial cell density in eye banks still acceptable? The French experience

Author

Thuret, G., Manissolle, C., Acquart, S., Petit, J-C Le, Maugery, J., Campos-Guyotat, L., Doughty, M.J., and Gain, P.

Subjects
Research, Ophthalmology -- Research
Abstract

Aim: To examine the differences in manual endothelial cell counting methods in French eye banks and to analyse whether these differences could explain some substantial discrepancies observed in endothelial cell [...]

Published
2003

34. Mechanisms of staurosporine induced apoptosis in a human corneal endothelial cell line. (Laboratory Science)

Author

Thuret, G., Chiquet, C., Herrag, S., Dumollard, J-M., Boudard, D., Bednarz, J., Campos, L., and Gain, P.

Subjects
Research, Cornea -- Research, Cell death -- Research
Abstract

Background: Apoptosis very probably plays a key part in endothelial cell loss during corneal storage in organ culture as well as hypothermic storage. However, the mechanisms underlying endothelial apoptosis are [...]

Published
2003

37. Sensitivity and rapidity of blood culture bottles in the detection of cornea organ culture media contamination by bacteria and fungi. (Laboratory Science)

Author

Thuret, G., Carricajo, A., Chiquet, C., Vautrin, A.C., Celle, N., Boureille, M., Acquart, S., Aubert, G., Maugery, J., and Gain, P.

Subjects
Physiological aspects, Research, Cornea -- Physiological aspects -- Research, Bacteria -- Physiological aspects -- Research, Organ culture -- Physiological aspects -- Research, Blood culture -- Physiological aspects -- Research, Fungi -- Physiological aspects -- Research, Organs, Culture of -- Physiological aspects -- Research
Abstract

Aims: To test the bactericidal activity of standard organ culture medium, and to compare the sensitivity and rapidity of blood culture bottles with conventional microbiological methods for detection of bacteria [...]

Published
2002

38. Automated tri-image analysis of stored corneal endothelium. (Laboratory Science)

Author

Gain, P., Thuret, G., Kodjikian, L., Gavet, Y., Turc, P.H., Theillere, C., Acquart, S., and Petit, J.C. Le

Subjects
Physiological aspects, Methods, Cornea -- Physiological aspects -- Methods, Endothelium -- Physiological aspects -- Methods, Ophthalmology -- Methods -- Physiological aspects
Abstract

Background: Endothelial examination of organ culture stored corneas is usually done manually and on several mosaic zones. Some banks use an image analyser that takes account of only one zone. [...]

Published
2002

39. Cornea procurement from very old donors: Post organ culture cornea outcome and recipient graft outcome. (Clinical Science)

Author

Gain, P., Thuret, G., Chiquet, C., Rizzi, P., Pugniet, J.L., Acquart, S., Colpart, J.J., Petit, J.C. Le, and Maugery, J.

Subjects
Physiological aspects, Cornea -- Physiological aspects, Organ preservation -- Physiological aspects, Endothelium -- Physiological aspects, Cytology -- Physiological aspects, Preservation of organs, tissues, etc. -- Physiological aspects
Abstract

Aim: To study the suitability of corneas from very old donors for graft after banking and their clinical and endothelial outcomes in recipients. Methods: 419 corneas stored in organ culture [...]

Published
2002

40. Value of two mortality assessment techniques for organ cultured cornea I endothelium: Trypan blue versus TUNEL technique. (Clinical Science)

Author

Gain, P., Thuret, G., Chiquet, C., Dumollard, J.M., Mosnier, J.F., Burillon, C., Delbosc, B., Herve, P., and Campos, L.

Subjects
Diagnosis, Physiological aspects, Case studies, Methods, Cornea -- Case studies -- Physiological aspects -- Methods, Diagnosis -- Methods -- Case studies -- Physiological aspects, Endothelium -- Physiological aspects -- Case studies -- Methods, Cell death -- Diagnosis -- Case studies -- Methods -- Physiological aspects
Abstract

Background/aim: It is known that trypan blue staining is not a good predictor of loss of corneal endothelial cells (ECs) during organ culture. As it is primarily an indicator of [...]

Published
2002

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