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Objective: This study aimed to investigate the prevalence of autism spectrum disorder and its possible correlations with clinical characteristics in patients with infantile epileptic spasms syndrome in a single center in Brazil. Methods: This retrospective cross-sectional study examined 53 children with the diagnosis of infantile epileptic spasms syndrome prior to an autism spectrum disorder assessment. Participants were divided into two groups based on the presence or absence of autism spectrum disorder. Available variables (sex, medications, median age at onset of infantile epileptic spasms syndrome, and presence of comorbidities) were compared using Mann–Whitney U or chi-square tests. Results: Among the included patients, 12 (23 %) were diagnosed with autism spectrum disorder, corresponding to a relative risk of 0.29 (95 % confidence interval 0.174–0.492). The age at the first seizure ranged from 3 to 15 months, with a mean of 6.65 months. This age significantly differed between participants with autism spectrum disorder (10.58 months) and those without (5.43 months), p

Despite β-type Ti alloys achieving a low elastic modulus, metallic implants generally exhibit poor wear resistance. To address this issue, in-situ Ti-based matrix composites (TMCs) are considered due to their strong bonding at the matrix/reinforcement interface. While TiC particles and TiB whiskers are common reinforcements for in-situ TMCs, limited research combines their effects with the low elastic modulus of Ti alloys. Here, we present a novel approach using arc-melting on Ti–40Nb alloy with 5 vol% additions of NbC, NbB2, and B4C. Respectively, three TMCs were obtained with the β-type Ti–Nb matrices reinforced individually with TiC particles, TiB whiskers, and hybridized with both. The produced TMCs exhibited the same passive behavior of the unreinforced Ti–40Nb alloy. However, tribocorrosion resistances were improved, as TMCs achieved nobler potentials during sliding than the unreinforced alloy (−0.5 and −0.9 V, respectively). Notably, the TiB-reinforced and the hybrid reinforced TMCs displayed minimal wear damage, while the TiC-reinforced TMC achieved a remarkable low elastic modulus of approximately 73 GPa. This study introduces promising alternatives for wear-resistant load-bearing implant applications.

The growing prevalence of digital crimes, especially those involving Child Sexual Abuse Material (CSAM) and revenge pornography, highlights the need for advanced forensic techniques to identify and analyze illicit content. While cryptographic hashing is commonly used in computer forensics, its effectiveness is often challenged because criminals can modify original information to create a new cryptographic hash. Perceptual hashes address this problem by focusing on the visual identity of the file rather than its bit-by-bit representation. This study introduces ChaSAM Forensics, a methodology that efficiently identifies illicit material using perceptual hashing techniques to track and identify illicit content, with a focus on child abuse material. Two new perceptual hashing algorithms, chHash and domiHash, were designed for integration into ChaSAM. The results showed that, under the tested conditions, the proposed chHash algorithm was more accurate than the established pHash algorithm when applied in a single iteration. Combinations of algorithms in two iterations were also assessed.

Electromagnetic forces can lead to the structural failure of power transformers due to extreme loading conditions, vibration, and/or fatigue. Therefore, studying the nature and the magnitude of these forces is a key task in the design and failure analysis of such important equipment. Keeping this issue in mind, this work aims at conducting a numerical analysis in order to evaluate the mechanical stresses and displacements of windings in power transformers due to the action of electromagnetic forces. With this purpose, a finite element model is developed considering electromagnetic and mechanical effects assuming short-circuit conditions. The study compares the cases employing copper and aluminum windings with header tap, in different temperatures. The model developed in this work is verified against analytical solutions. The numerical calculations allow for performing a detailed analysis in terms of the distribution of both displacements and stresses along the windings, which is of great relevance for identifying critical structural points and avoiding structural failure. Overall, the obtained results demonstrate that the finite element model is a useful tool for the structural design of power transformers that allow for investigating and optimizing key aspects before manufacturing.

IntroductionMucopolysaccharidoses (MPS) constitute a group of progressive and multisystemic inherited metabolic diseases that profoundly affect both the mental health of patients and the wellbeing of their families. This study aims to evaluate the impact of MPS on family functioning and related factors.Methods and resultsTwenty-five patients with MPS, including types I (n = 4), II (n = 11), IIIB (n = 2), IVA (n = 3), and VI (n = 5), and their families participated in this study. The mean patient age was 13 years [standard deviation (SD): 7.7 years]. Behavioral and emotional problems were noted in 9.1% of all patients. While the type of MPS did not directly influence mental problems, the presence of neuronal involvement did (p = 0.006). Patients with MPS III exhibited difficulties primarily in emotional areas, conduct, hyperactivity, and peer problems. Importantly, both patients with MPS II and those with MPS III experienced a significant impact on communication [mean scores for communication domain: MPS II, 35.6 (SD: 24.3); MPS III, 35.0 (SD: 22.6)]; poorer communication was directly linked to worse adaptive behavior (p = 0.012), and worse adaptive behavior was associated with lower quality of life (p = 0.001). Quality of life and caregiver burden among family members did not significantly differ across MPS types; however, higher caregiver burden was negatively associated with quality of life (p = 0.002). Concerning family functioning, the most impacted domains included independence, intellectual/cultural orientation, activity/recreation, and expressiveness. Domain scores did not vary based on MPS type, treatment, or neurological involvement. Quality-of-life scores were positively associated with the cultural/intellectual domain score.ConclusionThe impacts of quality of life and family extend beyond clinical characteristics and MPS type, strongly influenced by patient cognition and communication, as well as type of family functioning, especially those with greater cultural/intellectual skills of their family members. A multidisciplinary approach addressing the broader needs of individuals with MPS becomes essential. Techniques aimed at improving communication, including prompt interventions such as speech therapy and augmentative and alternative communication strategies, can contribute to overall family functioning improvement.

O tórus é uma protuberância óssea benigna, que acomete a maxila e a mandíbula, de etiologia multifatorial, estando associado a fatores genéticos e ambientais. O objetivo deste estudo é relatar um caso clínico com foco no manejo cirúrgico de tórus mandibular bilateral que necessitou de remoção cirúrgica com finalidade protética. Paciente, do sexo masculino, de 64 anos, compareceu à Clínica Odontológica da Faculdade Adventista da Bahia (FADBA), buscando tratamento reabilitador protético. Ao exame físico intraoral, presença de edentulismo parcial em ambas as arcadas dentárias, bem como presença de massa endurecida e assintomática em rebordo alveolar lingual mandibular bilateralmente foram constatadas. Optou-se, assim, por realizar a cirurgia para exérese do tórus mandibular. Foi realizado bloqueio do nervo alveolar inferior e lingual bilateralmente, confecção do retalho tipo envelope, descolamento mucoperiosteal, osteotomia com sulcos de orientação e clivagem dos blocos ósseos, regularização do rebordo com broca maxicut, irrigação copiosa com soro fisiológico, seguida de sutura interpapilar. Por tratar-se de patologia assintomática na maior parte dos casos, dispensa tratamento. Em casos de maior extensão, no entanto, quando ocorrem lesões traumáticas de repetição relacionadas à alimentação, às alterações fonéticas ou algum empecilho para o tratamento protético reabilitador, indica-se remoção cirúrgica. Após a avaliação clínica, foi definido o diagnóstico de tórus mandibular, esclareceu-se o paciente sobre a necessidade de remoção cirúrgica, uma vez que a presença das exostoses impossibilitaria o tratamento protético. Após a cirurgia, o paciente foi encaminhado para dar seguimento ao seu tratamento reabilitador.

Intestinal malrotation is a congenital anomaly caused by incomplete rotation or absence of rotation of the primitive intestine along the axis of the upper mesenteric artery during embryonic development. Embryonic development and its anatomical variations were described by Dott in 1923. Intestinal malrotation is a rare condition among adults – prevalent in a mere 0.0001% to 0.19% of the population –, and it may be associated with other anatomical deformities. It can be asymptomatic or manifest with varying intensity, from obstruction to necrosis of intestinal segments. In general, this abnormality is diagnosed in the first year of life; however, symptoms may appear later in life, making diagnosis in adults difficult on account of non-specific symptoms. In the present study, we report a case of intestinal malrotation associated with chronic non-specific symptoms progressing to mesenteric angina.

Raimundo de Farias Brito (1862-1917) teria todas as características para ser mais um entre os muitos retirantes que figuram a história tanto do Ceará como de qualquer outra região do Nordeste Brasileiro. Porém as realidades que permearam a sua vida, desde criança na pequena vila de São Benedito até a sua morte no Rio de Janeiro, são marcos que se apresentam na maneira do filósofo de enxergar o mundo e assim procurar desvendá-lo. Seguindo essa perspectiva esse texto procura apresentar alguns elementos que compõem a trajetória do filósofo ao sair de São Benedito, os primeiros estudos em Sobral, a ida a Fortaleza e a realização de seus estudos de Direto na Faculdade do Recife. Nesse entremeio a realidade da seca contrastando com a Belle Époque presente em Fortaleza e a renovação cultural vivenciada no Recife marcam a sua forma de questionar o que está ao seu redor construindo um arcabouço filosófico que pensa a realidade presente e lança perspectivas de suas consequências. O texto encontra-se dividido em três partes apresentando o panorama geral da época, seguindo pela construção histórica de Farias Brito culminando com seus estudos na Escola do Recife.

This study produced non-equiatomic TiNbZrTaMn and TiNbZrTaMo high entropy alloy (HEAs) by argon arc-melting and heat-treated for microstructural homogenization. The phase composition, microstructure, and selected mechanical properties were measured and compared with theoretical predictions. Additionally, electrochemical and cytotoxicity tests evaluated their potential applicability for use as biomaterials. X-ray diffraction measurements patterns showed a single BCC phase for the TiNbZrTaMn and a secondary HCP phase for the TiNbZrTaMo sample. The microstructural analysis revealed the formation of irregular grain boundaries and some lamellae formation, with chemical segregation of the alloying elements at the sub-micro-scale. The samples exhibited elastic modulus (80–110 GPa) closer to CP-Ti grade 2 (100 GPa) and higher Vickers microhardness (450–550 HV) than Ti–6Al–4V alloy (400 HV). The electrochemical and biological tests indicated a superior corrosion resistance against 0.9% NaCl solution compared with commercial metallic biomaterials, with proper cell adhesion and viability of pre-osteoblastic cells and hydrophilic behavior. Altogether, the data indicate that TiNbZrTaMn depicts better applicability potential for being used as a biomaterial in biomedical applications than some commercial materials (SS 316L, CP-Ti grade 2, and Ti–6Al–4V), mainly considering load-bearing orthopedical implants.

Abstract In this paper, the authors present a proposal for an application of electromagnetic bandgap (EBG), for suppression of grating lobes, in frequency selective surfaces (FSS), not yet studied in the literature. An alternative type of EBG with square holes was proposed to reduce the computational effort in simulations. The study consists of an application of a rectangular periodic array of cylindrical and square holes in FSS dielectric substrate to create rejection bands and suppress specific resonant frequency modes. We built four prototypes and compared measured results with simulated results obtained with ANSYS HFSS. Simulations and measurements show suppression levels up to 6 dB. A good agreement between the results is observed. The FSS with EBG with square holes allows a simulation time 70 % lower than FSS with EBG with cylindrical holes.

Objective: To compare the agreement of clinical and radiographic diagnosis with the histopathological diagnosis in fibro-osseous lesions of the jaws. Material and Methods: An analytical and exploratory study was made based on systematic collected data, carried out in the laboratory of surgical pathology of a public Dental School. There were evaluated cases of fibrous dysplasia (FD), cemento-osseous dysplasia (COD) and ossifyng fibroma (OF), diagnosed by clinical, radiographic (panoramic and periapical radiography), and histopathological analysis, in a period of 12 years (from March 2001 to June 2013). Descriptive and inferential statistics (Fisher's exact test) were obtained. Results: Ninety-six cases of FOLs were evaluated. The radiographic aspects of the FOLs studied did not differ significantly (p=0.09). Radiolucent lesions were the least frequent, corresponding to approximately 13.5% of radiographic findings. Mixed lesions and radiopaques were more present, how they were COD and FD, respectively. The more aggressive variation of OF (Juvenile Ossifying Fibroma - JOF) was less frequent among the pathologies evaluated. In approximately 61.46% of the cases clinical and radiographic diagnosis were confirmed by histopathological diagnosis of FOLs. The highest agreement and the highest disagreement were observed in COD cases (40.7% and 62.2%, respectively). Conclusion: FOLs of the maxillaries represent a group of lesions in which the establishment of the clinical and radiographic diagnosis supported by the histopathological confirmation is critical and challenging.

Este artigo é parte de pesquisa em andamento e tem por objetivo mapear e analisar os valores destinados pelo município de Rondonópolis/MT para a organização Cáritas Diocesana de Rondonópolis, entre 2008 e 2019. Fundada na cidade no ano de 1942, a Cáritas anuncia que seu propósito é continuar transformando a sociedade e fornecendo educação básica de qualidade. É uma organização da sociedade civil, filantrópica, sem fins lucrativos, declarada de utilidade pública em nível federal, estadual e municipal. Como previsto na LDB nº 9.394/96 e em acordo com o histórico modelo de atendimento à educação infantil brasileira, a organização recebe subvenção de recursos da Secretaria Municipal de Educação para atendimento à educação infantil, por meio de leis editadas anualmente. Pretende-se demonstrar a movimentação dos gastos, a redução das matrículas subvencionadas na entidade e o aumento do valor aluno da Cáritas comparado ao da rede pública municipal.

O uso de planilhas de ensino-aprendizagem no ensino presencial ou remoto fornece ao aluno uma nova perspectiva de ensino. Auxilia no desenvolvimento da capacidade de avaliar as possibilidades e variáveis do estudo em diferentes situações, uma vez que a planilha é de fácil utilização e muito versátil. O objetivo do presente estudo foi demostrar de maneira simplificada como montar uma planilha utilizando os softwares Microsoft Excel ou LibreOffice Calc para a determinação do fluxo de calor em placa plana (telhado) com os efeitos da radiação na superfície externa utilizando o método numérico da Bisseção. O exercício proposto engloba diferentes disciplinas dos cursos de Engenharia e a planilha se torna uma aliada positiva para a explicação e compreensão dos assuntos abordados. Foram mostrados todos os passos que devem ser seguidos para a montagem e realização do exercício e foi obtido um fluxo de calor de 29,4335 W/m² nas condições propostas e 71 iterações foram necessárias.

Introdução: A Anatomia humana é uma disciplina complexa, de base introdutória na estrutura curricular dos cursos de saúde. Trata-se de uma disciplina de suma importância para o profissional de Enfermagem, pois, além de fornecer o conhecimento necessário para o seu trabalho, é essencial para a compreensão de outros conteúdos durante a graduação. Sendo a Anatomia uma disciplina introdutória e com uma grande carga teórico-prática, os estudantes enfrentam desafios para aprendê-la. Nesse caso, a monitoria surge como uma estratégia essencial de auxílio no processo de ensino-aprendizagem, de disciplinas indispensáveis à formação profissional. Objetivo: avaliar o impacto da monitoria acadêmica na disciplina de Anatomia Humana para estudantes de Enfermagem. Material e métodos: trata-se de um estudo descritivo com abordagem quantitativa, realizado numa instituição de ensino superior privada, na cidade de Aracati-Ce. A amostra da pesquisa foi constituída por 100 acadêmicos do curso de Enfermagem, de todos os períodos, os quais frequentavam ou já frequentaram as aulas de monitoria acadêmica de Anatomia Humana. O instrumento utilizado para a coleta de dados foi um questionário com doze perguntas subjetivas. Resultados: de modo geral, os discentes do curso de Enfermagem estão satisfeitos com a forma com a qual monitoria vem sendo exercida, uma vez que esta é vista como um fator positivo e essencial para o fortalecimento do aprendizado. Conclusão: os alunos do curso de Enfermagem conseguiram compreender melhor a disciplina de Anatomia Humana através das aulas de monitoria.

Oil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, increasing the drug absorption. Triamcinolone acetonide (TA) is one of the first pharmacologic strategies applied as an intravitreal injection in the treatment of age-related macular degeneration (AMD). Newly synthesized quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and quinuclidine surfactants have been screened with the purpose to select the best compound to formulate long-term stable NEs that combine the best physicochemical properties for the loading of TA intended for ocular administration.

Quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and of quinuclidine surfactants were used to develop oil-in-water nanoemulsions with the purpose of selecting the best long-term stable nanoemulsion for the ocular administration of triamcinolone acetonide (TA). The combination of the best physicochemical properties (i.e., mean droplet size, polydispersity index, zeta potential, osmolality, viscoelastic properties, surface tension) was considered, together with the cell viability assays in ARPE-19 and HMC3 cell lines. Surfactants with cationic properties have been used to tailor the nanoemulsions’ surface for site-specific delivery of drugs to the ocular structure for the delivery of TA. They are tailored for the eye because they have cationic properties that interact with the anionic surface of the eye.

Root-knot nematode (RKN) is a serious threat to crops worldwide due to the difficulty in controlling it and the limited eco-friendly alternatives to deal with the biotic stress it causes. In the present work, water-extractable fractions obtained from vermicompost (WSFv), vermicompost enriched with Trichoderma asperellum (WSFta) and T. virens (WSFtv) were tested as biotechnological tools to reduce the impacts of RKN on gas exchange, water use efficiency (WUE) and nutrient concentration in tomato and bell pepper plants. The plants were infected with 5000 eggs and eventual J2 of RKN and then treated with the water-extractable fractions for seven weeks. It was observed that the addition of WSFta, WSFtv and WSFv increased the CO2 assimilation, stomatal conductance and WUE in the tomato plants. In the bell pepper plants, WSFta, WSFtv, WSFv increased the stomatal conductance, while WUE was higher in the treatment with WSFtv. In fact, the parameters associated with the gas exchange were usually higher in the bell pepper than in the tomato plants. Overall, higher contents of N, Mg, B and Mn were detected when the extracts were applied in both bell pepper and tomato plants. The application of the water-extractable fractions, inoculated or not with Trichoderma, attenuates the RKN damage on the gas exchange parameters and successfully enhanced the nutrient concentration in the infected tomato and bell pepper plants, showing that it could be an important and promising tool for reducing the damage caused by this pathogen. We suggest that both the tomato and pepper plants can cope with the dilemma between growth and stress response via stomata regulation that are modulated by the WSF and Trichoderma.

Rice husk collected in Barreiras City, Bahia, Brazil was converted to rice husk ash (RHA) by acidic or basic leaching, followed by calcination. The resulting RHA was modified with vanadium pentoxide (2, 5, or 10 mass% of V2O5). The modified RHA samples were characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). RHA exhibited FTIR bands associated with silica. After modification of acid-leached RHA with vanadium, the XRD data indicated the formation of V2O5 phases. Base-leached RHA modified with vanadium pentoxide showed the presence of the V2O5 phase only in the sample containing 10 mass% V2O5. The FTIR data indicated the formation of cristobalite, where bands associated with Si-O-V interactions were observed only for the sample with 10 mass% V2O5 prepared with acid-leached RHA. DOI: http://dx.doi.org/10.17807/orbital.v9i2.916

Este artigo pretende apresentar de forma sucinta uma das noções mais importantes do filósofo lituano-francês Emmanuel Levinas: a noção de rosto. Desde a nossa leitura, a noção de rosto é a chave para o entendimento de todo o pensamento de Levinas. O rosto é o modo próprio da alteridade absoluta do outro, não é que a alteridade possua um rosto, mas se é alteridade porque se é rosto. A partir do rosto do outro ser humano o mundo da socialidade e do sentido se abre e com ele também a possibilidade da violência e da injustiça. Mas também é somente por meio dele que a justiça pode ter sentido e realização. Palavras-chave: Rosto; Alteridade; Justiça; Violência. THE NOTION OF FACE IN EMMANUEL LEVINAS ABSTRACT This article intend to expose one of the most important notions from the philosopher french-lithuanian Emmanuel Levinas: the notion of face. In our reading, the notion of face is the key to understand Levinas’ thought. The face is the own alterity mode, it is not that the alterity possess a face, in fact, the alterity is the face. From the face of another human being, the world of the sociality and of the purport opens, as the very possibility of violence and injustice too. But also, it is just by it that justice can have a sense and realization. Keywords: Face; Alterity; Justice; Violence. LA NOCIÓN DEL ROSTRO EM EMMANUEL LEVINAS RESUMEN Este artículo tiene la intención de presentar brevemente una de las nociones más importantes del filósofo lituano-francés Emmanuel Levinas: la noción del rostro. Desde nuestra lectura, la noción del rostro es la clave para entender todo el pensamiento de Levinas. El rostro es la forma misma de la alteridad absoluta del otro, no es que la alteridad tiene un rostro, pero és alteridad porque és rostro. Apartir del rostro del otro ser humano, el mundo de la sociabilidad y del sentido se abre y con ella la posibilidad de la violencia y la injusticia. Pero es sólo a través de él que la justicia puede tener sentido y realización. Palabras clave: Rostro; Alteridad; Justicia; Violencia.

Este texto tem como objetivo colaborar com o esforço de revelar e discutir uma possível genealogia das políticas queer no Brasil. A pesquisa propõe um deslocamento do que se tem escrito nesse campo de conhecimento, primeiro, por entender que a historiografia do queer no Brasil se dá de maneira regionalizada – tomando colonialmente o Sul e Sudeste como centro legítimo; e, segundo, por negligenciar o papel da arte na composição de sua historiografia. Para tal, será debatido o trabalho do cineasta tropicalista Jomard Muniz de Britto, que traz consigo uma potência para pensar numa política de gênero e sexualidade de modo dissidente e no Nordeste.

Polymers such as the biocompatible polyhydroxybutyrate (PHB) and the polysaccharide chitosan (Chi), a pH-sensitive polymer, have been studied for drug delivery applications and scaffolds production. In this work, matrices of PHB and Chi were produced by compression molding (SPHB-Chi) and loaded with a broad-spectrum biocide chlorhexidine (CHX) (SPHB-Chi-CHX). The matrices were analyzed by scanning electron microscope (SEM). The SPHB-Chi capacity to absorb and deliver CHX was evaluated by UV-Vis. The antibacterial activity of the samples against S. aureus, P. aeruginosa and E. coli (most common pathogens that cause infection in several body sites) was evaluated using the disk-agar diffusion method. The CHX release results were fitted by the Power Law model. The results suggested that the morphology and the CHX delivery profile were directly related to the Chi amount in the samples and also showed that the SPHB-Chi-CHX is able to inhibit the microorganism proliferation, constituting it as a potential candidate for oral applications.

Devido às incertezas econômicas, para que as empresas permaneçam competitivas, um alto investimento é necessário para que haja ganhos adicionais de mercado, investimentos que não garantem um retorno econômico para a empresa. Diante dessas dificuldades, as empresas vêm desenvolvendo novas metodologias de gestão que visam não somente ao lucro do negócio, partindo para um enfoque voltado para a geração de riqueza dos acionistas. Assim, o objetivo deste trabalho é demonstrar como os indicadores de rentabilidade e direcionadores de valor contribuem para uma gestão mais eficaz, gerando valor para o acionista e tornando a empresa mais competitiva no mercado. Para isso, a metodologia utilizada foi um estudo de caso da empresa Energisa S/A., uma empresa de capital aberto do ramo de energia elétrica listada na BM&FBovespa. Após análise do resultado e discussão sobre o tema, conclui-se que uma boa gestão e preparo por parte dos administradores e acionistas, os indicadores de rentabilidade e direcionadores de valor contribuem para o aumento da competitividade no mercado e geração de valor.

In this study aimed to evaluate the possibility of using industrial boiler ash and rice husk ash in removing the commercial pesticide (carbofuran) in aqueous solution. These solids were collected in the Barreiras/BA, were heat treated and characterized by XRD and FT-IR. The adsorption experiments were performed in batch and the carbofuran removal was quantified using the spectrophotometry in the UV region. XRD data showed high silica content in boiler ash, which was reinforced by FT-IR analyses, showing the band FT-IR associated with presence of silica. In the FT-IR analysis of rice husk ash, this band relative to silica also were observed. The potential of adsorption of the ash industrial boiler and rice husk ash was verified obtaining significant results in the removal of carbofuran at low concentrations (2 mg/L), showing 100% of removal of pesticides from 720 min, used the ash industrial boiler, giving these materials a promising character as adsorbents. In the kinetic study of carbofuran adsorption, the mechanism of pseudo-second-order was better adjusted using the RHA as adsorbent, with a correlation coefficient (R2) of 0.997. The adsorption equilibrium was adjusted better to model of adsorption isotherm of Freundlich with a correlation coefficient of 0.999. DOI: http://dx.doi.org/10.17807/orbital.v1i1.716

Context The size of colorectal lesions, besides a risk factor for malignancy, is a predictor for deeper invasion Objectives To evaluate the malignancy of colorectal lesions ≥20 mm. Methods Between 2007 and 2011, 76 neoplasms ≥20 mm in 70 patients were analyzed Results The mean age of the patients was 67.4 years, and 41 were women. Mean lesion size was 24.7 mm ± 6.2 mm (range: 20 to 50 mm). Half of the neoplasms were polypoid and the other half were non-polypoid. Forty-two (55.3%) lesions were located in the left colon, and 34 in the right colon. There was a high prevalence of III L (39.5%) and IV (53.9%) pit patterns. There were 72 adenomas and 4 adenocarcinomas. Malignancy was observed in 5.3% of the lesions. Thirty-three lesions presented advanced histology (adenomas with high-grade dysplasia or early adenocarcinoma), with no difference in morphology and site. Only one lesion (1.3%) invaded the submucosa. Lesions larger than 30 mm had advanced histology (P = 0.001). The primary treatment was endoscopic resection, and invasive carcinoma was referred to surgery. Recurrence rate was 10.6%. Conclusions Large colorectal neoplasms showed a low rate of malignancy. Endoscopic treatment is an effective therapy for these lesions.

O presente trabalho pretende apresentar um panorama nacional sobre as pesquisas em linguagem e formação de conceitos no Ensino de Química, tendo como base o Diretório de Grupos de Pesquisa no Brasil, existente no portal do CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico). Dada a importância da linguagem e da apropriação de conceitos científicos no processo de ensino-aprendizagem dos educandos, evidenciado pelos autores que defendem a teoria construtivista, é importante que pesquisas nesta área sejam incentivadas, pois a apropriação, ou não, desses saberes por parte dos professores, tem reflexo direto na prática pedagógica e na qualidade do ensino de Química. A pesquisa realizada constatou que o número de linhas de pesquisas nesta área ainda é muito pequeno no nosso país, não chegando à proporção de 1:1 por unidade federativa, apesar do crescimento em pesquisas no Ensino de Química nos últimos anos.

Purpose: The aim of this study was to investigate possible predictive factors related to anterior chamber fibrin formation after vitreoretinal surgery in a large series of patients. Methods: The data of 185 eyes of 185 patients submitted to vitreoretinal surgery was reviewed. The following variables were evaluated: the postoperatively presence of fibrin, age, diabetes mellitus, the vitrectomy system gauge (20, 23 or 25 gauge), the type of vitreous substitute, the influence of prior surgical procedures and the combination with cataract extraction. To evaluate predictive factors for anterior chamber fibrin formation, univariate analysis was performed. A multivariate stepwise logistic regression model was adjusted to investigate factors associated with fibrin formation (p

Este estudo teve como objetivo descrever o caminho percorrido pela criança, adolescente e suas famílias, desde o iníciodos sinais e sintomas até a definição do diagnóstico de câncer. Métodos: Trata-se de estudo descritivo-exploratório, com abordagem qualitativa. Utilizou-se entrevista semiestruturada como recurso para coleta do material empírico. Estes foram agrupados na categoria "a longa peregrinação: do adoecimento ao início do tratamento". Resultados: Participaram do estudo 10 familiares de crianças e adolescentes com diagnóstico de câncer em tratamento quimioterápico. Os sujeitos relataram as experiências de forma detalhada e cronológica, descreveram o início dos sinais e sintomas, as idas e vindas pelos serviços de saúde, e a atuação dos profissionais no setor primário e no especializado. Conclusão: Conclui-se que a criança e o adolescente percorrem um longo caminho diante da situação oncológica. Foram evidenciadas as dificuldades relacionadas ao acesso aos recursos diagnósticos, o que compromete as possibilidades de um diagnóstico precoce.

Em telecomunicações, com o crescimento da demanda de tráfego de dados nas redes de terceira geração (3G), as operadoras de telefonia móvel têm atentado para o direcionamento dos recursos em infraestrutura nos locais onde se identifica maior necessidade. O direcionamento desses investimentos tem o objetivo de manter a qualidade do serviço prestado, principalmente, em regiões urbanas densas. Neste trabalho, é realizada a predição de séries temporais em redes HSPA – WCDMA dos parâmetros: potência recebida (Rx Power), potência de código do sinal recebido (Received Signal Code Power – RSCP), relação energia por chip em função da interferência (Energy per chip/Interference – Ec/Io) e taxa de transmissão (throughput) na camada física. A coleta dos valores dos parâmetros foi realizada numa rede em pleno funcionamento através de um drive test na cidade de Natal – RN. O modelo utilizado para predição das séries temporais foi o Modelo de Alisamento Exponencial de Holt. O objetivo das predições das séries temporais é verificar para quais parâmetros da rede HSPA – WCDMA o modelo de Holt melhor se adequou.

Methanolic extract of Suillus luteus was previously shown to inhibit proliferation of colon cancer cells with mutant p53. The effect of the same extract was further investigated here in a wildtype (wt) p53 non-small cell lung cancer cell line. Treatment with the extract increased the levels of p-H2A.X and the number of p-H2A.X foci/cell, indicating a possible increase in deoxyribonucleic acid (DNA) damage. Nevertheless, it did not cause alterations in wt p53 levels nor in programmed cell death. The extract caused inhibition of cellular proliferation and an increase in the % of cells in the G0/G1 phase of the cell cycle. In conclusion, even though there is evidence of DNA damage being caused by this extract, there is no induction of cell death in this p53 wt cell line.

A violência sexual é problema de saúde pública global e ações têm sido implementadas para estimular estudos no tema, a fim de propor intervenções de prevenção e atendimento adequado. Este trabalho objetivou caracterizar a população de mulheres que sofreram violência sexual, e descrever as características da agressão e do atendimento dispensado em um serviço universitário de referência. Estudo quantitativo e retrospectivo com atendimentos por violência sexual de junho de 2006 a dezembro de 2010. Avaliadas 687 mulheres, a maioria branca, solteira, sem filhos, com idade média de 23,7 anos, escolaridade entre fundamental e média, empregadas, com religião e prática religiosa. Um quarto sem relação sexual anterior. Violência sexual principalmente à noite, na rua, por agressor desconhecido e único, via vaginal e com intimidação. A maioria contou para outras pessoas e se sentiu apoiada. Atendimento precoce para quase 90% das mulheres, instaurando medidas profiláticas. Ocorreu aumento da procura precoce ao longo do período. Conhecer melhor as características da população e do evento pode auxiliar a estruturação e qualificação de modelos de atendimento.

A violência sexual é problema de saúde pública global e ações têm sido implementadas para estimular estudos no tema, a fim de propor intervenções de prevenção e atendimento adequado. Este trabalho objetivou caracterizar a população de mulheres que sofreram violência sexual, e descrever as características da agressão e do atendimento dispensado em um serviço universitário de referência. Estudo quantitativo e retrospectivo com atendimentos por violência sexual de junho de 2006 a dezembro de 2010. Avaliadas 687 mulheres, a maioria branca, solteira, sem filhos, com idade média de 23,7 anos, escolaridade entre fundamental e média, empregadas, com religião e prática religiosa. Um quarto sem relação sexual anterior. Violência sexual principalmente à noite, na rua, por agressor desconhecido e único, via vaginal e com intimidação. A maioria contou para outras pessoas e se sentiu apoiada. Atendimento precoce para quase 90% das mulheres, instaurando medidas profiláticas. Ocorreu aumento da procura precoce ao longo do período. Conhecer melhor as características da população e do evento pode auxiliar a estruturação e qualificação de modelos de atendimento.La violencia sexual es un problema global de salud pública y se han implementado acciones para estimular estudios en el tema, a fin de proponer intervenciones de prevención y atención adecuadas. Este trabajo tuvo por objetivo caracterizar la población de mujeres que sufrió violencia sexual, y describir las características de la agresión y de la atención dispensada en un servicio universitario de referencia. Se trata de un estudio cuantitativo y retrospectivo sobre la atención por violencia sexual de junio de 2006 a diciembre de 2010. Se evaluaron a 687 mujeres, la mayoría blanca, soltera, sin hijos, con una edad media de 23,7 años, escolaridad entre básica y media, con empleo, con religión y practicantes. Un cuarto sin relación sexual anterior. La violencia sexual principalmente se produce por la noche, en la calle, cometida por un agresor desconocido y único, vía vaginal y con intimidación. La mayoría se lo contó a otras personas y se sintió apoyada. Hubo atención precoz para casi un 90% de las mujeres, estableciendo medidas profilácticas. Se produjo un aumento de la búsqueda temprana del servicio a lo largo del período. Conocer mejor las características de la población y de los hechos puede auxiliar en la estructuración y cualificación de modelos de atención.Rape is a global public health problem, and steps have been taken to encourage studies on the issue and propose interventions for its prevention and appropriate care. This study aimed to characterize the population of female rape victims and describe the characteristics of the sexual assault and the care provided at a university referral center. This was a quantitative retrospective study of care provided to female rape victims from June 2006 to December 2010. The majority of the women (n = 687) were white, single, had no children, with a mean age of 23.7 years and primary to secondary schooling, employed, and practiced a religion. One-fourth of the victims reported no sexual intercourse prior to the sexual assault. Rape occurred mainly at night, on the street, perpetrated by a single stranger, with vaginal penetration, and with threatened or actual force. Most of the victims had reported the rape to someone and felt supported. Early care occurred for almost 90% of women, allowing preventive measures. From 2006 to 2010 there was an increase in the proportion of women that sought help. Better knowledge of the characteristics of this group and the event itself can help improve the structure and functioning of models to assist rape victims.

Objective: To describe the sociodemographic and clinical profile of patients who underwent electroconvulsive therapy (ECT) at a university general hospital. Method: In this retrospective study, records from all patients undergoing ECT between January 1988 and January 2008 at the psychiatric unit of the general hospital of Universidade Estadual de Campinas (UNICAMP) were reviewed. Telephone contact was made with patients/relatives to collect follow-up data. Results: A total of 200 charts were reviewed. The majority of patients were women, with a mean age of 39 years, and history of psychiatric hospitalization. The main indications for ECT were depression and catatonia. Complications were observed in less than half of the cases, and most were temporary and not severe. There was a good psychiatric outcome for 89.7% of the patients, especially for catatonic patients (100%, p = 0.02). Thirty-four percent of the cases were later contacted by telephone calls, at a mean of 8.5 years between the procedure and the contact. Among these, three (1.5%) reported persistent memory disorders and 73% considered ECT a good treatment. Conclusion: ECT has been performed according to international guidelines. In the vast majority of cases, undesirable effects were temporary and not severe. Response to ECT was positive in most cases, particularly in catatonic patients.

Emerging in the 1970s, the Wargame Chainmail and the first RPG shared the medieval fantasy genre to explore interactive narratives. In this article, we’ll analyze the main vast narratives of the medieval fantasy genre involving RPG and Wargames and its transmedia’s implications. Some systems of rules have their game mechanics discussed, building the basis for the experience of using the RPG as a tool for creative support and cohesion of narrative in the scenario Shiang’s Lands. Using rules of both, RPG and Wargame, this article exposes the creative process and the transmedia’s implications of the expe-rience analyzed.

Surgidos na década de 1970, o Wargame Chainmail e o primeiro RPG compartilharam o gênero da fan-tasia medieval para explorar narrativas interativas. Neste artigo são analisadas as principais vastas narrativas do gênero fantástico medieval envolvendo RPG e Wargame e as implicações transmidiáticas das adaptações. Alguns sistemas de regras têm suas mecânicas de jogo discutidas, trazendo base para a experiência do uso do RPG como ferramenta de apoio criativo e de coesão de narrativa no cenário Terras de Shiang. Utilizando regras de RPG e de Wargame, o artigo mostra o processo criativo e as im-plicações transmidiáticas da experiência analisada.

Nanotechnology is expected to play a vital role in the rapidly developing field of nanomedicine, creating innovative solutions and therapies for currently untreatable diseases, and providing new tools for various biomedical applications, such as drug delivery and gene therapy. In order to optimize the efficacy of nanoparticle (NP) delivery to cells, it is necessary to understand the mechanisms by which NPs are internalized by cells, as this will likely determine their ultimate sub-cellular fate and localisation. Here we have used pharmacological inhibitors of some of the major endocytic pathways to investigate nanoparticle uptake mechanisms in a range of representative human cell lines, including HeLa (cervical cancer), A549 (lung carcinoma) and 1321N1 (brain astrocytoma). Chlorpromazine and genistein were used to inhibit clathrin and caveolin mediated endocytosis, respectively. Cytochalasin A and nocodazole were used to inhibit, respectively, the polymerisation of actin and microtubule cytoskeleton. Uptake experiments were performed systematically across the different cell lines, using carboxylated polystyrene NPs of 40 nm and 200 nm diameters, as model NPs of sizes comparable to typical endocytic cargoes. The results clearly indicated that, in all cases and cell types, NPs entered cells via active energy dependent processes. NP uptake in HeLa and 1321N1 cells was strongly affected by actin depolymerisation, while A549 cells showed a stronger inhibition of NP uptake (in comparison to the other cell types) after microtubule disruption and treatment with genistein. A strong reduction of NP uptake was observed after chlorpromazine treatment only in the case of 1321N1 cells. These outcomes suggested that the same NP might exploit different uptake mechanisms to enter different cell types.

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