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22 results on '"Tian, Aiping"'

5. Systematic elucidation of the traditional Chinese medicine prescription Danxiong particles via network pharmacology and molecular docking

Author

Li, Ning, Liu, Keixin, Yu, Mai, Li, Shani, Liu, Mingjuan, Cai, Wei, and Tian, Aiping

Subjects
Danxiong particles, Traditional Chinese medicine, Network Pharmacology, Molecular docking, Pharmaceutical Science, Pharmacology (medical)
Abstract

Purpose: To investigate the pharmacological effect of the traditional Chinese medicine (TCM) prescription Danxiong particles (TDX105) and its mechanism of action.Methods: The active compound and targets of TDX105 were investigated via network pharmacology. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were enriched, and protein-protein interaction network (PPI) was constructed. A network of ‘components-targets-pathways’ was developed with Cytoscape 3.8.0 software, while the formation of molecular docking analysis was conducted using Autodock vina software.Results: There were 304 compounds and 482 targets identified in total. Genes with degree ≥ mean node values were selected as the crucial targets, and string database was to be combined to 64 targets identified with cytoscape so as to draw a protein interaction map. A total of 137 pathways were enriched from 64 targets involving mainly 10 pathways, for example, PI3K-Akt signaling pathway, pathways in cancer, human cytomegalovirus infection and focal adhesion. Then, compound-target and compoundtarget- pathways were constructed using cytoscape (3.8.0). Finally, the five most active compounds, viz, quercetin, myricetin, luteolin, ellagic acid and kaempferol, and the top ten targets AKT1, GAPDH, TP53, ALB, EGFR, MAPK3, JUN, MAPK1, SRC and ESR1 were selected for molecular docking. These targets and compounds had strong interactions through a combination of hydrogen bonds and hydrophobic forces.Conclusion: The mechanism of action of TDX105 has been successfully explained using the combination of network pharmacology and molecular docking. This may offer a solid foundation to the clinical use of TDX105, and further strengthen the prospects of its development for clinical use.

Published
2022

10. Systemic Therapy for Hepatocellular Carcinoma: Chinese Consensus-Based Interdisciplinary Expert Statements

Author

Sun, Yongkun, primary, Zhang, Wen, additional, Bi, Xinyu, additional, Yang, Zhengqiang, additional, Tang, Yu, additional, Jiang, Liming, additional, Bi, Feng, additional, Chen, Minshan, additional, Cheng, Shuqun, additional, Chi, Yihebali, additional, Han, Yue, additional, Huang, Jing, additional, Huang, Zhen, additional, Ji, Yuan, additional, Jia, Liqun, additional, Jiang, Zhichao, additional, Jin, Jing, additional, Jin, Zhengyu, additional, Li, Xiao, additional, Li, Zhiyu, additional, Liang, Jun, additional, Liu, Lianxin, additional, Liu, Yunpeng, additional, Lu, Yinying, additional, Lu, Shichun, additional, Meng, Qinghua, additional, Niu, Zuoxing, additional, Pan, Hongming, additional, Qin, Shukui, additional, Qu, Wang, additional, Shao, Guoliang, additional, Shen, Feng, additional, Song, Tianqiang, additional, Song, Yan, additional, Tao, Kaishan, additional, Tian, Aiping, additional, Wang, Jianhua, additional, Wang, Wenling, additional, Wang, Zhe, additional, Wu, Liqun, additional, Xia, Feng, additional, Xing, Baocai, additional, Xu, Jianming, additional, Xue, Huadan, additional, Yan, Dong, additional, Yang, Lin, additional, Ying, Jianming, additional, Yun, Jingping, additional, Zeng, Zhaochong, additional, Zhang, Xuewen, additional, Zhang, Yanqiao, additional, Zhang, Yefan, additional, Zhao, Jianjun, additional, Zhou, Jianguo, additional, Zhu, Xu, additional, Zou, Yinghua, additional, Dong, Jiahong, additional, Fan, Jia, additional, Lau, Wan Yee, additional, Sun, Yan, additional, Yu, Jinming, additional, Zhao, Hong, additional, Zhou, Aiping, additional, and Cai, Jianqiang, additional

Published
2022
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14. A phase II randomized placebo-controlled study investigating the combination of yiv-906 and sorafenib (SORA) in HBV (+) patients (Pts) with advanced hepatocellular carcinoma (HCC).

Author

Harding, James J., primary, Abou-Alfa, Ghassan K., additional, Shi, Yuankai, additional, Whang-Peng, Jacqueline, additional, Yuen, Man Fung, additional, Saif, Wasif M., additional, Tian, Aiping, additional, Gu, Shanzhi, additional, Lam, Wing, additional, Liu, Shwu-Huey, additional, Cheng, Yung-Chi, additional, Chu, Edward, additional, and Yen, Yun, additional

Published
2020
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16. Systemic Therapy for Hepatocellular Carcinoma: Chinese Consensus-Based Interdisciplinary Expert Statements

Author

Sun, Yongkun, Zhang, Wen, Bi, Xinyu, Yang, Zhengqiang, Tang, Yu, Jiang, Liming, Bi, Feng, Chen, Minshan, Cheng, Shuqun, Chi, Yihebali, Han, Yue, Huang, Jing, Huang, Zhen, Ji, Yuan, Jia, Liqun, Jiang, Zhichao, Jin, Jing, Jin, Zhengyu, Li, Xiao, Li, Zhiyu, Liang, Jun, Liu, Lianxin, Liu, Yunpeng, Lu, Yinying, Lu, Shichun, Meng, Qinghua, Niu, Zuoxing, Pan, Hongming, Qin, Shukui, Qu, Wang, Shao, Guoliang, Shen, Feng, Song, Tianqiang, Song, Yan, Tao, Kaishan, Tian, Aiping, Wang, Jianhua, Wang, Wenling, Wang, Zhe, Wu, Liqun, Xia, Feng, Xing, Baocai, Xu, Jianming, Xue, Huadan, Yan, Dong, Yang, Lin, Ying, Jianming, Yun, Jingping, Zeng, Zhaochong, Zhang, Xuewen, Zhang, Yanqiao, Zhang, Yefan, Zhao, Jianjun, Zhou, Jianguo, Zhu, Xu, Zou, Yinghua, Dong, Jiahong, Fan, Jia, Lau, Wan Yee, Sun, Yan, Yu, Jinming, Zhao, Hong, Zhou, Aiping, and Cai, Jianqiang

Abstract

Background:Hepatocellular carcinoma (HCC) is the most common type of liver cancer and causes many cancer-related deaths worldwide; in China, it is the second most prevalent cause of cancer deaths. Most patients are diagnosed clinically with advanced stage disease. Summary:For more than a decade, sorafenib, a small-molecular-weight tyrosine kinase inhibitor (SMW-TKI) was the only molecular targeted drug available with a survival benefit for the treatment of advanced HCC. With the development of novel TKIs and immune checkpoint inhibitors for advanced HCC, the management of patients has been greatly improved. However, though angiogenic-based targeted therapy remains the backbone for the systemic treatment of HCC, to date, no Chinese guidelines for novel molecular targeted therapies to treat advanced HCC have been established. Our interdisciplinary panel on the treatment of advanced HCC comprising hepatologists, hepatobiliary surgeons, oncologists, radiologists, pathologists, orthopedic surgeons, traditional Chinese medicine physicians, and interventional radiologists has reviewed the literature in order to develop updated treatment regimens. Key Messages:Panel consensus statements for the appropriate use of new molecular -targeted drugs including doses, combination therapies, adverse reaction management as well as efficacy evaluation, and predictions for treatment of advanced HCC with evidence levels based on published data are presented, thereby providing an overview of molecular targeted therapies for healthcare professionals.

Published
2021
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18. Interaction transfer function matrix and the design of multivariable control systems

Author

Zhao Yiqun and Tian Aiping

Subjects
Matrix (mathematics), Control theory, Nyquist stability criterion, Multivariable calculus, Diagonal, Scalar (physics), Nyquist–Shannon sampling theorem, Transfer function, Stability (probability), Computer Science::Databases, Mathematics
Abstract

The ITF (interaction transfer function) technique has been developed to reduce the multivariable design problem to a sequence of scalar problems. The ITF can be easily calculated and used to determine the stability of the multivariable systems by using a computer-aided design technique. The stability can be determined from Nyquist loci of some diagonal ITFs. The compensation of multivariable systems can be achieved by compensating the diagonal ITFs of an ITF matrix directly. Two examples are used to demonstrate the use of the design technique. >

Published
2003

21. Anti-helicobacter pylori effect of total alkaloids of sophora alopecuroides in vivo.

Author

Tian A, Xu T, Liu K, Zou Q, and Yan X

Subjects
Animals, Cyclooxygenase 2 metabolism, Female, Helicobacter Infections drug therapy, Helicobacter pylori metabolism, Immunohistochemistry, Interleukin-8 metabolism, Mice, Mice, Inbred BALB C, NF-kappa B metabolism, Omeprazole therapeutic use, Real-Time Polymerase Chain Reaction, Alkaloids pharmacology, Alkaloids therapeutic use, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents therapeutic use, Helicobacter pylori drug effects, Sophora chemistry
Abstract

Background: Helicobacter pylori (H. pylori) infection could lead to most gastroduodenal diseases and is even identified as a carcinogen of gastric cancer. Total alkaloids of sophora alopecuroides (TASA) is widely used in herbal remedies to treat various infectious diseases, including stomach-associated diseases. This study is aimed at evaluating the antimicrobial activity of TASA on H. pylori-infected BALB/c mice mouse gastritis., Methods: Totally 120 BALB/c mice were orally inoculated with H. pylori Bacterial liquid to construct BALB/c mice H. pylori infection gastritis animal model, after the model was successfully created. We randomly assigned 100 infected mice into 10 treatment groups, the first group (normal saline); the second group (bismuth pectin); the third group (omeprazole); the fourth group (TASA 2 mg/d); the fifth group (TASA 4 mg/d); the sixth group (TASA 5 mg/d); the seventh group (TASA + bismuth pectin); the eighth group (TASA + omeprazole); the ninth group (bismuth pectin + clarithromycin + metronidazole); the tenth group (omeprazole + clarithromycin + metronidazole), 5 other non-infected mice as negative control. Mice were orally inoculated twice a day and 7 days continuously. Then the mice were killed 4 weeks after treatment, we used realtime PCR to detect 16sDNA of H. pylori to test both the colonization and the clearance mice of bacteria of each treatment. We applied hematoxylin and eosin (HE) staining and immunostaining of mice gastric mucosa to observe the general inflammation and related factors interleukin 8 (IL-8), cyclooxygenase 2 (COX-2), and nuclear factor-kappa B (NF-κB) expression change after treatments., Results: Firstly, we ensured that after 6-week intragastric administration, the bacteria colonization reached an exceed peak which is far higher than positive threshold (P < 0.001); secondly, after treatments, it is revealed that TASA combined with omeprazole or bismuth pectin showed promising antimicrobial activity against H. pylori as well as conventional triple therapy (P < 0.001); thirdly, HE staining showed that the inflammation on mice gastric mucosal membrane were also relieved obviously in TASA combined treatments and conventional triple therapy compared with normal saline treated mice, moreover, from immunohistochemistry results, H. pylori-induced IL-8, COX-2, and NF-κB were consistently suppressed in seventh, eighth, ninth, and tenth group to a certain extent., Conclusion: These results open the possibility of taking TASA as an anti-inflammatory agent for H. pylori gastritis.

Published
2014

22. [Effect of qianjin huanglian pill on kidney in insulin resistance mice].

Author

Tian A, Zou C, Sun S, Chen Y, Guo S, and Shen Z

Subjects
Animals, Blood Glucose metabolism, Chemistry, Pharmaceutical, Dose-Response Relationship, Drug, Female, Kidney pathology, Kidney Glomerulus drug effects, Kidney Glomerulus pathology, Male, Mice, Sodium Glutamate toxicity, Drugs, Chinese Herbal pharmacology, Insulin Resistance, Kidney drug effects
Abstract

Objective: To investigate the effect of qianjin huanglian pill on kidney in monosodium L-glutamate (MSG)-treated insulin resistance (IR) mice., Method: The ameliorative effect of qianjin huanglian pill on IR in MSG mice was evaluated in comparison with rosiglitazone (Ros). The fasting serum glucose, fasting serum insulin, insulin sensitivity index, urinary albumin excretion, glomerular diameter and pathological changes of kidney were investigated in the evaluation., Result: After 2 weeks of qianjin huanglian pill treatment, the urinary albumin excretion (UAE) was reduced in low-dose group (P < 0.05) as compared with the model group. After 4 weeks of qianjin huanglian pill treatment, the fasting serum glucose was reduced in high-dose group (P < 0.001 compared with the model group). ISI of mice was ameliorated in high-dose group (P < 0.05 compared with the model group). The glomerular diameter was decreased, the hyperplasia of glomerulus was ameliorated in high-dose and low-dose groups (P < 0.01 compared with model group)., Conclusion: In MSG mice, we found qianjin huanglian pill could increase insulin sensitivity, decrease the urinary albumin excretion, ameliorate the pathological changes of kidney due to insulin resistance.

Published
2009

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