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Abstract: Numerical simulation is applied to analyze surrounding stress distribution of individual cells and the reasons are proposed why roof caving easily happens at apex angle and at the center of roadway. Furthermore, based on key factors of roof caving and mechanics derivation of neutral axis''s new position in roof beam, the superiority of prestressed truss cable and its key component--connector is thoroughly analyzed in safety management of anti-caving. Finally, according to the geometric size and abutment pressure influence of coal roadway No. 9101 in Danshuigou coal mine, prestressed truss cable combined control scheme and its corresponding parameters are designed by use of numerical simulation method and engineering analogue method, then the scheme have been put into practice on spot. The field observation results show that roof should be effectively controlled by the cable truss structure consisting of two long cables and one connector, which could prevent roof accidents fundamentally at a super-large section roadway with thick and fractural coal roof. [Copyright &y& Elsevier]

Objective: To identify the main active components in Shenbing decoction Ⅲ and their targets and explore the mechanism by which Shenbing decoction Ⅲ alleviates proteinuria in chronic kidney disease (CKD) based on network pharmacology., Methods: The active components of Shenbing decoction Ⅲ and their potential targets, along with the oral bioavailability and drug-like properties of each component were searched in the TCMSP database. The proteinuria-related targets were searched in the GeneCards database. The active component-target network was constructed using Cytoscape software, and the acquired information of the targets from ClueGO was used for enrichment analysis of the gene pathways., Results: A total of 102 active components were identified from Shenbing decoction Ⅲ. These active components acted on 126 targets, among which 69 were related to proteinuria. Enrichment analysis revealed fluid shear stress- and atherosclerosisrelated pathways as the highly significant pathways in proteinuria associated with CKD., Conclusions: We preliminarily validated the prescription of Shenbing decoction Ⅲ and obtained scientific evidence that supported its use for treatment of proteinuria in CKD. The findings in this study provide a theoretical basis for further study of the mechanism of Shenbing decoction Ⅲ in the treatment of proteinuria in CKD.

Studies have shown that the clinical manifestation of patients with neuropsychiatric disorders might be related to the abnormal connectivity of brain functions. Psychogenic non-epileptic seizures (PNES) are different from the conventional epileptic seizures due to the lack of the expected electroencephalographically epileptic changes in central nervous system, but are related to the presence of significant psychological factors. Diagnosis of PNES remains challenging. We found in the present work that the connectivity between the frontal and parieto-occipital in PNES was weaker than that of the controls by using network analysis based on electroencephalogram (EEG) signals. In addition, PNES were recognized by using the network properties as linear discriminant nalysis (LDA) input and classification accuracy was 85%. This study may provide a feasible tool for clinical diagnosis of PNES.