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Your search keyword '"Tian, Dong-bo"' showing total 14 results
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14 results on '"Tian, Dong-bo"'

1. A Double-Blind Randomized Placebo-Controlled Phase 3 Trial of Tobramycin Inhalation Solution in Adults With Bronchiectasis With Pseudomonas aeruginosa Infection

Author

Guan, Wei-jie, Xu, Jin-fu, Luo, Hong, Xu, Xing-xiang, Song, Yuan-lin, Ma, Wan-li, Liang, Zong-an, Liu, Xue-dong, Zhang, Guo-jun, Zhang, Xiao-ju, Li, Rong-kai, Zhu, Shu-yang, Zhang, Yi-jie, Cai, Xing-jun, Wei, Li-ping, Tian, Dong-bo, Zhao, Hui, Chen, Ping-yan, Qu, Jie-ming, and Zhong, Nan-shan

Published
2023
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2. A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19

Author

Chen, Tao, primary, Lin, Yu-Xin, additional, Zha, Yan, additional, Sun, Ying, additional, Tian, Jinxiu, additional, Yang, Zhiying, additional, Lin, Shan-Wen, additional, Yu, Fuxun, additional, Chen, Zi-Sheng, additional, Kuang, Bo-Hua, additional, Lei, Jin-Ju, additional, Nie, Ying-jie, additional, Xu, Yonghao, additional, Tian, Dong-Bo, additional, Li, Ying-Zi, additional, Yang, Bin, additional, Xu, Qiang, additional, Yang, Li, additional, Zhong, Nanshan, additional, Zheng, Meizhen, additional, Li, Yimin, additional, Zhao, Jincun, additional, Zhang, Xiang-Yan, additional, and Feng, Lin, additional

Published
2021
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6. Discrete Element Simulation of lunar dust suspension caused by lunar rover wheel

Author

Tong Jing-Yu, Lv Zhen, Li Yu, Li Man, Wang Hailong, and Tian Dong-Bo

Subjects
Discrete element simulation, Dust particles, Collision model, Suspension (vehicle), Simulation based, Discrete element method, Geology, Astrobiology, Cosmic dust
Abstract

Lunar dust may be readily suspended from the lunar surface and transported by lunar rover. It can accumulate on sensitive power components and reduce their performance. This paper presents a Discrete Element Method (DEM) analysis of the lunar dust distribution caused by lunar rover wheel rotated. Based on the characteristics of lunar dust, a lunar dust particles collision model is built. A simulation based on Discrete Element Method which a specific lunar rover wheel with the speed of 0.5m/s, 1 m/s, 3 m/s,5 m/s, 7 m/s, the maximum height of raised lunar dust particles will be 0.015m, 0.024m, 0.32m, 1.20m, 3.20m. The simulation shows that when the faster the lunar rover travelling, the higher lunar dust raising caused by lunar rover. This quantitative analysis dedicates to the relationship between the speed of lunar rover traveling and height of lunar dust raising caused by lunar rover wheel. This research is significant for China Moon Exploration project. Meanwhile, this research provides a reference for Chinese lunar rover travelling under the lunar dust environment.

Published
2011

13. A Double-Blind Randomized Placebo-Controlled Phase 3 Trial of Tobramycin Inhalation Solution in Adults With Bronchiectasis With Pseudomonas aeruginosaInfection

Author

Guan, Wei-jie, Xu, Jin-fu, Luo, Hong, Xu, Xing-xiang, Song, Yuan-lin, Ma, Wan-li, Liang, Zong-an, Liu, Xue-dong, Zhang, Guo-jun, Zhang, Xiao-ju, Li, Rong-kai, Zhu, Shu-yang, Zhang, Yi-jie, Cai, Xing-jun, Wei, Li-ping, Tian, Dong-bo, Zhao, Hui, Chen, Ping-yan, Qu, Jie-ming, and Zhong, Nan-shan

Abstract

Few large-scale studies have demonstrated the efficacy of tobramycin nebulization in bronchiectasis. We evaluated the efficacy and safety of nebulized tobramycin inhalation solution (TIS) in adults with bronchiectasis with Pseudomonas aeruginosainfection.

Published
2022
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14. Regulation of smooth muscle contractility by the epithelium in rat tracheas: role of prostaglandin E 2 induced by the neurotransmitter acetylcholine.

Author

Zhao L, Liang YT, Tian DB, Zhang RG, Huang J, Zhu YX, Zhou WL, and Zhang YL

Abstract

Background: Previous studies have suggested the involvement of epithelium in modulating the contractility of neighboring smooth muscle cells. However, the mechanism underlying epithelium-derived relaxation in airways remains largely unclear. This study aimed to investigate the mechanism underlying epithelium-dependent smooth muscle relaxation mediated by neurotransmitters., Methods: The contractile tension of Sprague-Dawley (SD) rat tracheal rings were measured using a mechanical recording system. Intracellular Ca 2+ level was measured using a Ca 2+ fluorescent probe Fluo-3 AM, and the fluorescence signal was recorded by a laser scanning confocal imaging system. The prostaglandin E 2 (PGE 2 ) content was measured using an enzyme-linked immunosorbent assay kit., Results: We observed that the neurotransmitter acetylcholine (ACh) restrained the electric field stimulation (EFS)-induced contraction in the intact but not epithelium-denuded rat tracheal rings. After inhibiting the muscarinic ACh receptor (mAChR) or cyclooxygenase (COX), a critical enzyme in prostaglandin synthesis, the relaxant effect of ACh was attenuated. Exogenous PGE 2 showed a similar inhibitory effect on the EFS-evoked contraction of tracheal rings. Moreover, ACh triggered phospholipase C (PLC)-coupled Ca 2+ release from intracellular Ca 2+ stores and stimulated COX-dependent PGE 2 production in primary cultured rat tracheal epithelial cells., Conclusions: Collectively, this study demonstrated that ACh induced rat tracheal smooth muscle relaxation by promoting PGE 2 release from tracheal epithelium, which might provide valuable insights into the cross-talk among neurons, epithelial cells and neighboring smooth muscle cells in airways., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-5500). The authors have no conflicts of interest to declare., (2021 Annals of Translational Medicine. All rights reserved.)

Published
2021
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