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Three new dinuclear Co(II) complexes [Co2(L1)2Cl2](PF6)2 (1), [Co2L2(OAc)2(CH3OH)4](ClO4)2 (2), and [Co2L3(OAc)2(CH3OH)4](ClO4)2 (3) were synthesized and structurally determined by X‐ray single‐crystal diffraction analysis as well as IR, elemental analysis, and mass spectrometry. All complexes exhibit efficiently self‐activated cleavage activity with hydrolytic mechanism, which was accurately proved by addition of regular radical scavengers, anaerobic cleavage experiment, and 2‐thiobarbituric acid reaction. Complex 1 exhibited higher selective cytotoxicity against tumor cells than normal cells, which is significantly better than that of cisplatin. Hoechst 33342 staining, intracellular ROS generation and mitochondrial membrane potential were conducted to assess the apoptosis‐inducing activity of 1. The effect of complex 1 on cell invasion was observed by Transwell assay and angiogenesis experiment, and the results demonstrated that 1 could inhibit the cell invasion and angiogenesis. [ABSTRACT FROM AUTHOR]

A novel and highly efficient dual-targeting PtII system was designed to improve the drug delivery capacity and selectivity in cancer treatment. The dual-targeting monofunctional PtII complexes (1–8) having glycosylated pendants as tridentated ligand were achieved by introducing glycosylation modification in the thioaminocarbazone compounds with potential lysosomal targeting ability. The structures and stability of 1–8 were further established by various techniques. Molecular docking studies showed that 2 was efficiently docked into glucose transporters protein 1 (GLUT1) and P-glycoprotein (Pgp) proteins with the optimal CDocker-interaction-energy of −64.84 and −48.85 kcal mol−1. Complex 2 with higher protein binding capacity demonstrated significant and broad-spectrum antitumor efficacy in vitro, even exhibiting a half maximal inhibitory concentration (IC50) value (∼10 μM) than cisplatin (∼17 μM) against human lung adenocarcinoma cells (A549). The inhibitor experiment revealed GLUT-mediated uptake of 2, and the subcellular localization experiment in A549 also proved that 2 could be localized in the lysosome, thereby causing cell apoptosis. Moreover, cellular thermal shift assay (CETSA) confirmed the binding of 2 with the target proteins of GLUT1 and Pgp. The above results indicated that 2 represents a potential anticancer candidate with dual-targeting functions. [ABSTRACT FROM AUTHOR]

New Ag(I) supramolecular complexes were synthesized by the reactions of Ag(I) salts with two well-designed rigid bulky acridine-based ligands using elemental analyses, IR spectroscopy, and single-crystal X-ray diffraction analysis, respectively. The new suprameolcular complexes exhibit rare C-H...Ag H-bonding and Ag-O weak interactions.

Two chiral Cu(II) complexes of [Cu2( R-L)2](PF6)2·2C2H5OH ( 1) and [Cu2( S-L)2](PF6)2·2C2H5OH ( 2) (HL = 2-(Bis(quinolin-2-ylmethyl)amino)-1-propanol) were designed and synthesized to serve as chemical nucleases and anticancer drugs. X-ray crystallography revealed that two complexes contain chiral binuclear cations and PF6− anions. The interaction of two complexes with CT-DNA was researched via various spectroscopic techniques and viscosity measurement, indicating that the complexes were bound to CT-DNA by a classical intercalation binding mode. In addition, the two complexes exhibited remarkable DNA cleavage activity with an optimal dosage of 10 μM in the absence of any exogenous oxidant agent. Both of the complexes showed excellent in vitro cytotoxicity on A549 cell lines with IC50 values in the low micromolar range. Moreover, complex 2 could damage DNA of A549 cells into fragmentation and then induced cell apoptosis in a dose-dependent manner, which was demonstrated by comet assay and Hoechst 33342 staining experiment. Further research showed that complex 2 could also induce G2 and S phase cell cycle arrest. [ABSTRACT FROM AUTHOR]

The employment of a reduced Schiff-base ligand, 1,3-bis(3-methoxy-salicylamino)-2-propanol (H3L), with the assistance of acetate anions led to the isolation of eight heptanuclear heterometallic complexes containing [Cu5Ln2] cores. Single-crystal X-ray diffraction analyses have been performed for all the complexes and show that they all have dicationic [Cu5Ln2] cores with two nitrate or hexafluorophosphate anions to compensate the charge. The dicationic parts in 1–8 display centrosymmetric hexagonal-like arrangements in which one CuII ion sits on the inversion centre with six peripheral metal ions (two LnIII and four CuII) around it. The magnetic susceptibilities of all the complexes have been studied by dc magnetic measurements. The temperature dependent magnetic susceptibility data for the CuII–GdIII complex have been processed using PHI software. The results reveal that the magnetic exchange interactions between CuII and CuII ions are antiferromagnetic while those between CuII and GdIII ions are ferromagnetic. The magnetostructural correlations reveal that the bridging angles of Cu–O–Cu and Cu–O–Gd greatly influence the magnetic coupling of CuII–CuII and CuII–GdIII, respectively. Further, ac susceptibility studies have been carried out for DyIII and TbIII complexes and HoIII derivatives. The complexes CuII–HoIII and CuII–TbIII show slow magnetization relaxation behaviour of an SMM. [ABSTRACT FROM AUTHOR]