1. Prognostic implications of heart failure stages among Chinese community populations: insight from a nationwide population-based study.
- Author
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Zheng, Congyi, Cai, Anping, Wang, Xin, Qiu, Jiayuan, Song, Qingjie, Gu, Runqing, Cao, Xue, Tian, Yixin, Hu, Zhen, Fonarow, Gregg, Lip, Gregory, Wang, Zengwu, and Feng, Yingqing
- Subjects
Death ,Heart failure ,Population ,Preclinical stages - Abstract
BACKGROUND: In light of high burden of heart failure (HF) in China, studies of prognostic implication of HF stages are important. We aimed to evaluate the relationship between HF stages and mortality risk in Chinese community populations. METHODS: Nationwide representative populations aged ≥35 years (n = 23,284, mean age 56.9 years, women 53.2%) were enrolled from 2012 to 2016. According to the international HF guidelines, participants were divided into stage A, B and C, and those who did not qualify these stages were categorized as apparently-healthy group. Association between HF stages and all-cause, cardiovascular [CV] and non-CV death was evaluated using multivariable-adjusted Cox proportional regression analysis. FINDINGS: During a median follow-up of 4.7 years (109,902.8 person-years), 1314 deaths occurred. Age-adjusted incidence rate of all-cause death was 5.3 in apparently-healthy, 7.8 in stage A, 8.6 in stage B and 24.6 in stage C groups per 1000 person-years. In reference to apparently-healthy group, adjusted hazard ratio for all-cause death was 1.90 (95% CI: 1.47-2.45), 2.43 (95% CI: 1.89-3.13) and 6.40 (95% CI: 4.56-8.99) for stage A, B and C. Advancing HF stages were associated with increasing risks for all-cause, CV and non-CV death (P-trend
- Published
- 2024