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30 results on '"Tian, Yuzi"'

3. Serum citrullinated histone H3 concentrations differentiate patients with septic verses non-septic shock and correlate with disease severity.

Author

Li, Yongqing, Karmakar, Monita, Liu, Baoling, Puskarich, Michael, Jones, Alan, Stringer, Kathleen, Standiford, Theodore, Alam, Hasan, Tian, Yuzi, and Russo, Rachel

Subjects
Citrullinated histone H3, Diagnosis, Outcomes, Peptidylarginine deiminase, Sepsis, Aged, Citrulline, Diagnosis, Differential, Female, Histones, Humans, Male, Middle Aged, Procalcitonin, Protein-Arginine Deiminase Type 2, Protein-Arginine Deiminase Type 4, Retrospective Studies, Shock, Shock, Septic, Treatment Outcome
Abstract

PURPOSE: Microbial infection stimulates neutrophil/macrophage/monocyte extracellular trap formation, which leads to the release of citrullinated histone H3 (CitH3) catalyzed by peptidylarginine deiminase (PAD) 2 and 4. Understanding these molecular mechanisms in the pathogenesis of septic shock will be an important next step for developing novel diagnostic and treatment modalities. We sought to determine the expression of CitH3 in patients with septic shock, and to correlate CitH3 levels with PAD2/PAD4 and clinically relevant outcomes. METHODS: Levels of CitH3 were measured in serum samples of 160 critically ill patients with septic and non-septic shock, and healthy volunteers. Analyses of clinical and laboratory characteristics of patients were conducted. RESULTS: Levels of circulating CitH3 at enrollment were significantly increased in septic shock patients (n = 102) compared to patients hospitalized with non-infectious shock (NIC) (n = 32, p

Published
2021

4. Rapid single-molecule digital detection of protein biomarkers for continuous monitoring of systemic immune disorders

Author

Song, Yujing, Sandford, Erin, Tian, Yuzi, Yin, Qingtian, Kozminski, Andrew G., Su, Shiuan-Haur, Cai, Tao, Ye, Yuxuan, Chung, Meng Ting, Lindstrom, Ryan, Goicochea, Annika, Barabas, Jenny, Olesnavich, Mary, Rozwadowski, Michelle, Li, Yongqing, Alam, Hasan B., Singer, Benjamin H., Ghosh, Monalisa, Choi, Sung Won, Tewari, Muneesh, and Kurabayashi, Katsuo

Published
2021
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14. Cl-Amidine Improves Survival and Attenuates Kidney Injury in a Rabbit Model of Endotoxic Shock

Author

Siddiqui, Ali Z., primary, Bhatti, Umar F., additional, Deng, Qiufang, additional, Biesterveld, Ben E., additional, Tian, Yuzi, additional, Wu, Zhenyu, additional, Dahl, Julia, additional, Liu, Baoling, additional, Xu, Jie, additional, Koike, Yui, additional, Song, Jun, additional, Zhang, Jifeng, additional, Li, Yongqing, additional, Alam, Hasan B., additional, and Williams, Aaron M., additional

Published
2021
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15. Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis

Author

Tian, Yuzi, primary, Qu, Shibin, additional, Alam, Hasan B., additional, Williams, Aaron M., additional, Wu, Zhenyu, additional, Deng, Qiufang, additional, Pan, Baihong, additional, Zhou, Jing, additional, Liu, Baoling, additional, Duan, Xiuzhen, additional, Ma, Jianjie, additional, Mondal, Santanu, additional, Thompson, Paul R., additional, Stringer, Kathleen A., additional, Standiford, Theodore J., additional, and Li, Yongqing, additional

Published
2020
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18. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

Author

Magupalli, Venkat Giri, primary, Negro, Roberto, additional, Tian, Yuzi, additional, Hauenstein, Arthur V., additional, Di Caprio, Giuseppe, additional, Skillern, Wesley, additional, Deng, Qiufang, additional, Orning, Pontus, additional, Alam, Hasan B., additional, Maliga, Zoltan, additional, Sharif, Humayun, additional, Hu, Jun Jacob, additional, Evavold, Charles L., additional, Kagan, Jonathan C., additional, Schmidt, Florian I., additional, Fitzgerald, Katherine A., additional, Kirchhausen, Tom, additional, Li, Yongqing, additional, and Wu, Hao, additional

Published
2020
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26. Peptidylarginine Deiminases 2 Mediates Caspase-1-Associated Lethality in Pseudomonas aeruginosa Pneumonia-Induced Sepsis.

Author

Wu, Zhenyu, Tian, Yuzi, Alam, Hasan B, Li, Patrick, Duan, Xiuzhen, Williams, Aaron M, Liu, Baoling, Ma, Jianjie, and Li, Yongqing

Subjects
*PSEUDOMONAS aeruginosa, *SEPSIS, *PATHOGENIC bacteria, *IMMUNOCOMPROMISED patients, *FLOW cytometry
Abstract

Background: Pseudomonas aeruginosa (PA) is a pathogenic bacterium that causes severe pneumonia in critically ill and immunocompromised patients. Peptidylarginine deiminase (PAD) 2, PAD4, and caspase-1 are important enzymes in mediating host response to infection. The goal of this study was to determine the interplay between PAD2, PAD4, and caspase-1 in PA pneumonia-induced sepsis.Methods: Pneumonia was produced in wild-type, Pad2-/-, and Pad4-/- mice by intranasal inoculation of PA (2.5 × 106 colony-forming units per mouse), and survival (n = 15/group) was monitored for 10 days. Bone marrow-derived macrophages (BMDMs) were isolated for in vitro studies. Samples were collected at specific timepoints for Western blot, bacterial load determination, and flow cytometry analysis.Results: Caspase-1-dependent inflammation was diminished in PA-inoculated Pad2-/- mice, contributing to reduced macrophage death and enhanced bacterial clearance. In addition, Pad2-/- mice exhibited improved survival and attenuated acute lung injury after PA infection. In contrast, Pad4-/- mice did not display diminished caspase-1 activation, altered bacterial loads, or improved survival.Conclusions: Peptidylarginine deiminase 2 plays an essential role in the pathogenesis of pulmonary sepsis by mediating caspase-1 activation. This goes against previous findings of PAD4 in sepsis. Our study suggests that PAD2 is a potential therapeutic target of PA pneumonia-induced sepsis. [ABSTRACT FROM AUTHOR]

Published
2021
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27. Complete and Partial Aortic Occlusion for the Treatment of Hemorrhagic Shock in Swine

Author

Williams, Aaron M., primary, Bhatti, Umar F., primary, Dennahy, Isabel S., primary, Chtraklin, Kiril, primary, Chang, Panpan, primary, Graham, Nathan J., primary, Baccouche, Basil M., primary, Roy, Shalini, primary, Harajli, Mohammed, primary, Zhou, Jing, primary, Nikolian, Vahagn C., primary, Deng, Qiufang, primary, Tian, Yuzi, primary, Liu, Baoling, primary, Li, Yongqing, primary, Hays, Gregory L., primary, Hays, Julia L., primary, and Alam, Hasan B., primary

Published
2018
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28. Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia

Author

Liang, Yingjian, primary, Pan, Baihong, additional, Alam, Hasan B., additional, Deng, Qiufang, additional, Wang, Yibing, additional, Chen, Eric, additional, Liu, Baoling, additional, Tian, Yuzi, additional, Williams, Aaron M., additional, Duan, Xiuzhen, additional, Wang, Yanming, additional, Zhang, Jifeng, additional, and Li, Yongqing, additional

Published
2018
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30. Peptidylarginine Deiminase 2 Knockout Improves Survival in hemorrhagic shock.

Author

Zhou J, Biesterveld BE, Li Y, Wu Z, Tian Y, Williams AM, Tian S, Gao W, Bhatti UF, Duan X, Wang T, Zhang J, Jiang B, Wang Z, and Alam HB

Subjects
Acute Lung Injury genetics, Acute Lung Injury pathology, Animals, Blotting, Western, Female, Mice, Mice, Knockout, Myocardial Infarction genetics, Protein-Arginine Deiminase Type 2 genetics, Acute Lung Injury metabolism, Myocardial Infarction metabolism, Myocardial Infarction pathology, Protein-Arginine Deiminase Type 2 metabolism, Shock, Hemorrhagic metabolism, Shock, Hemorrhagic pathology
Abstract

Background: The peptidylarginine deiminase (PAD) family converts arginine into citrulline through protein citrullination. PAD2 and PAD4 inhibitors can improve survival in hemorrhagic shock (HS). However, the impact of isoform-specific PAD inhibition in improving survival has not been studied. In this study, we utilize selective Pad2 knockout mice to elucidate loss of function of PAD2 leads to pro-survival effect in HS., Methods: HS: Pad2 and wild-type (WT) mice (n = 5/group) were subjected to lethal HS (55% volume hemorrhage). Survival was monitored over 7 days. Myocardial infarction (MI): Pad2 and WT mice (n = 9/group) were subjected to MI by permanent LAD ligation to examine the effect of ischemia on the heart. After 24 h cardiac function and infarct size were measured., Results: HS: Pad2 mice demonstrated 100% survival compared with 0% for WT mice (P = 0.002). In a sub-lethal HS model, cardiac β-catenin levels were higher in Pad2 compared with WT after 24 h. MI: WT mice demonstrated larger MI (75%) compared with Pad2 (60%) (P < 0.05). Pad2 had significantly higher ejection fraction and fractional shortening compared with WT (P < 0.05)., Conclusions: Pad2 improves survival in lethal HS. Possible mechanisms by which loss of PAD2 function improves survival include the activation of cell survival pathways, improved tolerance of cardiac ischemia, and improved cardiac function during ischemia. PAD2 is promising as a future therapeutic target for the treatment of HS and cardiac ischemia.

Published
2020
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