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6 results on '"Tian‐Lin Xue"'

2. Effects of SLCO1B1 on elimination and toxicities of high-dose methotrexate in pediatric acute lymphoblastic leukemia

Author

Fei-Fei Yang, Tian-Lin Xue, Chao Gao, Ying Wu, Wei Lin, Jun Li, Rui-Dong Zhang, Hu-Yong Zheng, and Shu-Guang Liu

Subjects
Pharmacology, Genetics, Molecular Medicine
Abstract

Aim: To evaluate the association between SLCO1B1 polymorphisms and elimination/toxicities of high-dose methotrexate (MTX). Methods: SLCO1B1 rs11045879 and rs4149056 polymorphisms were retrospectively genotyped in 301 children with newly diagnosed acute lymphoblastic leukemia. MTX concentration, doses of leucovorin rescue and toxicities were recorded. Results: SLCO1B1 rs11045879C carriers (CC + CT) had higher plasma MTX levels at 96 hr, and longer MTX elimination time. The number of leucovorin rescue doses in rs4149056C carriers (CC + CT) was more than those in TT ones. Moreover, SLCO1B1 polymorphisms were associated with HDMTX toxicities including thrombocytopenia, renal toxicity and anal mucositis, but not associated with MTX level at other time points or delayed elimination. Conclusions: Our data demonstrate that genotyping of SLCO1B1 might be useful to optimize MTX therapy.

Published
2022
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4. Effects of

Author

Fei-Fei, Yang, Tian-Lin, Xue, Chao, Gao, Ying, Wu, Wei, Lin, Jun, Li, Rui-Dong, Zhang, Hu-Yong, Zheng, and Shu-Guang, Liu

Subjects
Methotrexate, Liver-Specific Organic Anion Transporter 1, Leucovorin, Humans, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Child, Polymorphism, Single Nucleotide, Retrospective Studies
Published
2022

5. Prognostic significance of

Author

Yuan, Yuan, Jun, Li, Tian-Lin, Xue, Hai-Rui, Hu, Wei, Lin, Shu-Guang, Liu, Rui-Dong, Zhang, Hu-Yong, Zheng, and Chao, Gao

Subjects
F-Box-WD Repeat-Containing Protein 7, Neoplasm, Residual, Clinical Protocols, T-Lymphocytes, Ubiquitin-Protein Ligases, Mutation, Humans, Cell Cycle Proteins, Receptor, Notch1, Child, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Disease-Free Survival
Published
2022

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