1. Isolation of Lobane and Prenyleudesmane Diterpenoids from the Soft Coral Lobophytum varium
- Author
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Chuan-Hsiang Chang, Atallah F. Ahmed, Tian-Sheng Yang, You-Cheng Lin, Chiung-Yao Huang, Tsong-Long Hwang, and Jyh-Horng Sheu
- Subjects
lobane ,prenyleudesmane ,anti-inflammatory activity ,Lobophytum varium ,Biology (General) ,QH301-705.5 - Abstract
Further chemical investigation of the EtOAc extract of the soft coral Lobophytum varium resulted in the discovery of eleven new diterpenoids lobovarols F–P (1–11) of lobane– and prenyleudesmane–types, along with two known metabolites (12 and 13). The structures of the new metabolites were established by spectroscopic analyses, including 2D NMR experiments. The absolute configuration of 1 was determined using Mosher’s method. The complete assignment of 1H and 13C NMR spectroscopic data of 12 and 13 and the identification of pyran-derived moieties in the prenyleudesmanes were reported for the first time. Anti-inflammatory activities of the isolated compounds in suppressing elastase release and superoxide anion generation in human neutrophils were disclosed for 1, 2, 4, 12, and 13. A stereospecific biosynthesis for lobanes and prenyleudesmanes from the related prenylgermacranes could explain the coexistence of lobanes and prenylgermacranes in L. varium.
- Published
- 2020
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