67 results on '"Tie-Jian Feng"'
Search Results
2. Associations of sexually transmitted infections and bacterial vaginosis with abnormal cervical cytology: A cross-sectional survey with 9090 community women in China.
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Wu Li, Lan-Lan Liu, Zhen-Zhou Luo, Chun-Yan Han, Qiu-Hong Wu, Li Zhang, Li-Shan Tian, Jun Yuan, Tao Zhang, Zhong-Wei Chen, Tu-Bao Yang, Tie-Jian Feng, Min Zhang, and Xiang-Sheng Chen
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Medicine ,Science - Abstract
BackgroundAlthough it is well acknowledged that persistent infection with high-risk human papillomavirus types in genital sites plays a crucial role in the development of squamous cell cervical carcinoma, there is no unanimous consensus on the association between non-HPV sexually transmitted infections and abnormal cervical cytology.MethodsIn the present study, we evaluated cervical cytology status, sexually transmitted infections and bacterial vaginosis status, and collected social-demographic information among recruited participants to explore the association of STIs and bacterial vaginosis with abnormal cervical cytology.Results9,090 women's specimens were successfully tested, with a total of 8,733 (96.1%) women had normal cytology and 357 (3.9%) women exhibited abnormal cytology. The prevalence of HPV, Chlamydia trachomatis, Neisseria gonorrhoeae, and bacterial vaginosis was significantly higher in the ≥ASC-US group than the NILM group (PConclusionsOur results demonstrated that Neisseria gonorrhoeae infection in genital sites and/or bacterial vaginosis may independently increase the risk for cervical cytology abnormalities after adjusted for carcinogenic HPV-positive status. Besides, these results improved our understanding of the etiology of abnormal cervical cytology and may be useful for the management of women with ASC-US cytology.
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- 2020
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3. Chlamydia trachomatis infection among patients attending sexual and reproductive health clinics: A cross-sectional study in Bao'an District, Shenzhen, China.
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Rui-Lin Yan, Yun-Feng Ye, Qin-Ying Fan, Yan-Hui Huang, Gui-Chun Wen, Li-Mei Li, Yu-Mao Cai, Tie-Jian Feng, and Zhi-Ming Huang
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Medicine ,Science - Abstract
This study aimed to estimate the prevalence of chlamydial trachomatis (CT) infection and explore its risk factors among patients attending sexual and reproductive health clinics in Shenzhen, China. We collected demographic and clinical information from attendees (aged 18-49). CT and Neisseria gonorrhoeae (NG) infection was determined by nucleic acid amplification test (NAAT) on self-collected urine specimens. Of 1,938 participants recruited, 10.3% (95% confidence interval [CI]: 9.6%-11.0%) tested positive for CT. Prevalence was similar between men (10.6% [85/804]; 95% CI, 9.5%-11.7%) and women (10.1% [115/1134]; 95% CI: 9.2%-11.0%). Being 18-25 years old (adjusted odds ratio [aOR] = 2.52; 95%CI:1.35-4.71), never tested for CT before (aOR = 2.42; 95%CI: 1.05-5.61) and infected with NG(aOR = 3.87; 95%CI: 2.10-7.10) were independently associated with CT infection. We found that CT infection is prevalent among patients attending sexual and reproductive health clinics in Shenzhen, China. A comprehensive program including CT screening, surveillance and treatment is urgently needed.
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- 2019
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4. Population-based study of chlamydial and gonococcal infections among women in Shenzhen, China: Implications for programme planning.
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Zhen-Zhou Luo, Wu Li, Qiu-Hong Wu, Li Zhang, Li-Shan Tian, Lan-Lan Liu, Yi Ding, Jun Yuan, Zhong-Wei Chen, Li-Na Lan, Xiao-Bing Wu, Yu-Mao Cai, Fu-Chang Hong, Tie-Jian Feng, Min Zhang, and Xiang-Sheng Chen
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Medicine ,Science - Abstract
This study was aimed to estimate the prevalences of chlamydia (CT) and gonococcal (NG) infections and explore risk factors associated with the CT infection among women in Shenzhen, China. We collected socio-demographic and clinical data from women (aged 20-60) and determined positivity of CT or NG by nucleic acid amplification test (NAAT) with self-collected urine specimens. We estimated prevalence of CT and NG and determined risk factors associated with CT infection. Among 9,207 participants, 4.12% (95% confidence interval [CI], 3.71%-4.53%) tested positive for CT and 0.17% (95% CIs, 0.09%-0.25%) for NG. Factors significantly associated with CT infection included being an ethnic minority (ethnicity other than Han China) (Adjusted odds ratio [AOR], 1.9; 95% CI, 1.2-3.0), using methods other than condom for contraception (AOR, 1.5; 95% CI, 1.2-1.8), having a history of adverse pregnancy outcomes (AOR, 1.4; 95% CI, 1.1-1.8), and experiencing reproductive tract symptoms in the past three months (AOR, 1.3; 95% CI, 1.0-1.7). we found that CT infection is prevalent among women in Shenzhen, China and associated with both demographic and behavioral factors. A comprehensive CT screening, surveillance and treatment programme targeting this population is warranted.
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- 2018
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5. Correction: Population-based study of chlamydial and gonococcal infections among women in Shenzhen, China: Implications for programme planning.
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Zhen-Zhou Luo, Wu Li, Qiu-Hong Wu, Li Zhang, Li-Shan Tian, Lan-Lan Liu, Yi Ding, Jun Yuan, Zhong-Wei Chen, Li-Na Lan, Xiao-Bing Wu, Yu-Mao Cai, Fu-Chang Hong, Tie-Jian Feng, Min Zhang, and Xiang-Sheng Chen
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Medicine ,Science - Abstract
[This corrects the article DOI: 10.1371/journal.pone.0196516.].
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- 2018
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6. HPV infections among MSM in Shenzhen, China.
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Dong-Yan Zhang, Yue-Ping Yin, Tie-Jian Feng, Fu-Chang Hong, Ning Jiang, Bao-Xi Wang, and Xiang-Sheng Chen
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Medicine ,Science - Abstract
BACKGROUND: An increasing incidence of anal cancer among men, especially men who have sex with men (MSM) suggests a need to better understand anal human papillomavirus (HPV) infection among this group. METHODS: A cross-sectional study was conducted among MSM in Shenzhen, China. Blood was collected for HIV serological testing and syphilis serological screening, and anal swabs were collected for HPV genotyping. Difference of HPV prevalence between HIV seropositive and HIV seronegative MSM was assessed by chi-square test. Factors associated with anal canal HPV infection were assessed by univariate and multivariate logistic regression. RESULTS: A total of 408 MSM were recruited. HIV and HPV prevalence were 6.9% and 36.4%, respectively. HPV was detected in the anal canal in 71.4% of the HIV-positive MSM and in 33.8% of the HIV-negative MSM (P
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- 2014
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7. AIDS
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Lu, Pu-Xuan, Tie-Jian, Feng, Hui, Wang, Xing-Xian, Lu, Yong, Xiao, Shao-Biao, Huang, Yan, Liu, Xiao-Hua, Le, Wen-Ke, Zhu, Fan, Zhang, Qing, Wang, Lu, Pu-Xuan, editor, and Zhou, Bo-Ping, editor
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- 2016
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8. Reported prevalence of depression or depressive symptoms among men who have sex with men in China, 2004–2018: A systematic review and meta-analysis
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Tingting Wang, Hanlin Fu, Tubao Yang, Yumao Cai, Xiaobing Wu, and Tie-Jian Feng
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Male ,China ,HIV Infections ,Subgroup analysis ,Men who have sex with men ,Sexual and Gender Minorities ,03 medical and health sciences ,0302 clinical medicine ,Prevalence ,Humans ,Medicine ,Homosexuality, Male ,Depression (differential diagnoses) ,Depression ,business.industry ,Publication bias ,Random effects model ,Mental health ,030227 psychiatry ,Psychiatry and Mental health ,Clinical Psychology ,Sample size determination ,Meta-analysis ,business ,030217 neurology & neurosurgery ,Demography - Abstract
Background Depression is a major mental disorder that imposes a considerable burden on health. Men who have sex with men (MSM) are at high risk for depression. Numerous studies have reported the prevalence of depression or depressive symptoms among MSM in China. However, the estimates have varied substantially between studies. This meta-analysis aimed to establish the pooled prevalence of depression or depressive symptoms among Chinese MSM to attract public attention. Method A systematic search of several electronic databases and a subsequent manual search was performed to identify relevant studies. A random effects model was adopted to calculate the pooled prevalence of depression or depressive symptoms. Heterogeneity between studies and publication bias was also assessed. Results A total of 54 articles with a sample size of 21,950 MSM were analysed. The pooled prevalence of depression or depressive symptoms among MSM was 40.0% (95% CI: 37.9%-45.0%). Substantial heterogeneity was observed across individual studies. The pooled summary estimate stratified by screening instruments and cutoff scores ranged from 19.0% to 60.2%. Subgroup analysis indicated that survey dates, sampling method, HIV infection status and occupation can partially contribute to the between-study heterogeneity. Limitations The findings should be interpreted with caution because of several limitations related to the heterogeneity across studies, sampling method and quality assessment. Conclusions Overall, the reported prevalence of depression or depressive symptoms among Chinese MSM was fairly high. The study suggested that more attention and effective intervention programmes are urgently provided to prevent and improve mental health issues among Chinese MSM.
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- 2020
9. Prevalence and associated factors of chlamydial infection among patients seeking clinic-based STI services in Shenzhen, China
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Tie-Jian Feng, Yumao Cai, Li-Zhang Wen, Fuchang Hong, Chunlai Zhang, Fen Tang, Jianbin Ye, Wei-Ye Yu, Xiang-Sheng Chen, Honglin Wang, Feng Wang, Jin-Hong Liu, and Rongxing Weng
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business.industry ,Environmental health ,Medicine ,China ,business ,Chlamydial infection - Abstract
Objectives Prevalence assessment is one of the core components of WHO-recommended STI surveillance programming. This study aimed to provide prevalence and associated factors data for estimating the disease burden of CT, developing intervention programmes, and planning for resource allocations.Methods We carried out a cross-sectional survey among patients attending clinics for STI services. We collected background information from patients (aged 18-49) and determined positivity of CT by nucleic acid amplification test (NAAT) with self-collected urine specimens. Associated factors identified through logistic regression.Results Among the 8324 participants, 751 were detected to be positive for CT, giving an overall prevalence of 9.0% with 10.7% for male and 8.3% for female respectively. Aged older than 24 (OR=0.78, 95%CI=0.62-0.98), married (OR=0.61, 95%CI=0.50-0.75), college or higher education (OR=0.66, 95%CI=0.51-0.86), having no access to health insurance (OR=1.28, 95%CI=1.07-1.51), and positive for NG (OR=4.45, 95%CI=3.22-6.15) were factors found to be significantly associated with CT infection.Conclusions We found that CT infection is prevalent among patients seeking clinic-based STI services in Shenzhen, China. A comprehensive CT screening, surveillance, and treatment programme targeting this population are warranted. And the CT integrated prevention and control projects could be considered as routine public health services by the government.
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- 2020
10. Associations of sexually transmitted infections and bacterial vaginosis with abnormal cervical cytology: A cross-sectional survey with 9090 community women in China
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Zhongwei Chen, Jun Yuan, Tubao Yang, Zhenzhou Luo, Wu Li, Li Zhang, Tie-Jian Feng, Lishan Tian, Chun-Yan Han, Lan-Lan Liu, Tao Zhang, Qiuhong Wu, Min Zhang, and Xiang-Sheng Chen
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Viral Diseases ,Cross-sectional study ,Cervix Uteri ,Pathology and Laboratory Medicine ,medicine.disease_cause ,Chlamydia Infection ,0302 clinical medicine ,Residence Characteristics ,Surveys and Questionnaires ,Cytology ,Medicine and Health Sciences ,Medicine ,030212 general & internal medicine ,Chlamydia ,Young adult ,Trichomonas Vaginalis ,Multidisciplinary ,Obstetrics ,Eukaryota ,Protists ,Vaginosis, Bacterial ,Middle Aged ,Bacterial Pathogens ,Infectious Diseases ,Chlamydia Trachomatis ,Medical Microbiology ,Neisseria Gonorrhoeae ,030220 oncology & carcinogenesis ,Trichomonas ,Female ,Pathogens ,Bacterial vaginosis ,Neisseria ,Research Article ,Adult ,Human Papillomavirus Infection ,China ,medicine.medical_specialty ,Urology ,Science ,Sexually Transmitted Diseases ,Microbiology ,Young Adult ,03 medical and health sciences ,Bacterial Vaginosis ,Humans ,Sex organ ,Microbial Pathogens ,Bacteria ,Genitourinary Infections ,business.industry ,Organisms ,Biology and Life Sciences ,Correction ,Cell Biology ,medicine.disease ,Cross-Sectional Studies ,Etiology ,Neisseria gonorrhoeae ,business ,Chlamydia trachomatis - Abstract
BackgroundAlthough it is well acknowledged that persistent infection with high-risk human papillomavirus types in genital sites plays a crucial role in the development of squamous cell cervical carcinoma, there is no unanimous consensus on the association between non-HPV sexually transmitted infections and abnormal cervical cytology.MethodsIn the present study, we evaluated cervical cytology status, sexually transmitted infections and bacterial vaginosis status, and collected social-demographic information among recruited participants to explore the association of STIs and bacterial vaginosis with abnormal cervical cytology.Results9,090 women's specimens were successfully tested, with a total of 8,733 (96.1%) women had normal cytology and 357 (3.9%) women exhibited abnormal cytology. The prevalence of HPV, Chlamydia trachomatis, Neisseria gonorrhoeae, and bacterial vaginosis was significantly higher in the ≥ASC-US group than the NILM group (PConclusionsOur results demonstrated that Neisseria gonorrhoeae infection in genital sites and/or bacterial vaginosis may independently increase the risk for cervical cytology abnormalities after adjusted for carcinogenic HPV-positive status. Besides, these results improved our understanding of the etiology of abnormal cervical cytology and may be useful for the management of women with ASC-US cytology.
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- 2020
11. Association between syphilis seroprevalence and age among blood donors in Southern China: an observational study from 2014 to 2017
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Hanlin Fu, Lina Lan, Yumao Cai, Wei-Ye Yu, Xiaobing Wu, Yang Guan, Fengxin Wu, Feng Wang, Tie-Jian Feng, Chunlai Zhang, Fen Tang, and Jianbin Ye
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Adult ,Male ,medicine.medical_specialty ,China ,Epidemiology ,Psychological intervention ,syphilis ,Blood Donors ,Enzyme-Linked Immunosorbent Assay ,Serology ,03 medical and health sciences ,0302 clinical medicine ,Seroepidemiologic Studies ,Internal medicine ,medicine ,Prevalence ,Seroprevalence ,Humans ,Mass Screening ,030212 general & internal medicine ,Treponema pallidum ,Retrospective Studies ,Original Research ,business.industry ,Public health ,public health ,Age Factors ,General Medicine ,Middle Aged ,medicine.disease ,Antibodies, Bacterial ,Observational study ,Syphilis ,Female ,business ,030217 neurology & neurosurgery ,Treponema pallidum particle agglutination assay - Abstract
ObjectiveThis study investigated the association between syphilis seroprevalence and age among blood donors, and described the distribution of serological titres among syphilis-infected donors, aiming to confirm the syphilis epidemic characteristics and to promote effective interventions for older adults.MethodsData were obtained from the Shenzhen Programme for Syphilis Prevention and Control in 2014–2017. Blood samples were screened using the ELISAs, and confirmed using the Treponema pallidum particle agglutination assay (TPPA) and toluidine red unheated serum test (TRUST).ResultsAmong 394 792 blood donors, 733 tested TPPA and TRUST positive (active infection), and 728 tested only TPPA positive (historical infection). The overall prevalence of syphilis seropositivity was 370.1 per 100 000 (95% CI 351.1 to 389.0 per 100 000); the prevalence of active infection was 185.7 per 100 000 (95% CI 172.2 to 199.1 per 100 000). People aged ≥45 years displayed a prevalence of 621.8 per 100 000 in syphilis seropositivity and 280.5 per 100 000 in active infection, which were 3.8 times and 2.4 times higher than that for people aged 2trend=311.9, p trend2trend=72.1, p trendtrendConclusionsThe findings confirm the high prevalence of syphilis among older adults, and suggest the need to increase awareness among healthcare providers and deliver more targeted prevention interventions for older adults to promote early testing.
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- 2019
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12. Population survey of CCR5 Delta32, CCR5 m303, CCR2b 64I, and SDF1 3'A allele frequencies in indigenous Chinese healthy individuals, and in HIV-1-infected and HIV-1 uninfected individuals in HIV-1 risk groups
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Fu-Sheng Wang, Wei-Guo Hong, Yunzhen Cao, Ming-Xu Liu, Lei Jin, Liang-Ping Hu, Zhe Wang, Tie-Jian Feng, Jing Hou, Bing Zhang, Ming Shi, Dong-Ping Xu, Zhou-Yun Lei, Bo Wang, Zheng-Dong Liu, Jun-Jie Ye, Lin Peng, Ya Qiu, and Winkler, Cheryl
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Chemokines -- Physiological aspects ,Chemokine receptors -- Physiological aspects ,HIV infection -- Prevention ,HIV infection -- Demographic aspects ,HIV infection -- Risk factors ,HIV patients -- Health aspects ,HIV patients -- Care and treatment ,HIV patients -- Surveys ,HIV patients -- Demographic aspects ,AIDS (Disease) -- Research ,Health - Abstract
Research has been conducted on indigenous Chinese ethnic groups. The frequencies of chemokine and chemokine receptors have been determined in these groups, and the results demonstrate that there is no difference in genotype difference or allele between HIV-1-infected and HIV-1 uninfected groups from Han ethnic groups.
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- 2003
13. Risk of Congenital Syphilis (CS) Following Treatment of Maternal Syphilis: Results of a CS Control Program in China
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Fuchang Hong, Wei-Ye Yu, Xiaobing Wu, Lina Lan, Tie-Jian Feng, Fan Yang, Chun-Lai Zhang, Yingzhou Yang, Xiang-Sheng Chen, Yue-Ping Yin, and Yang Guan
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Adult ,Microbiology (medical) ,medicine.medical_specialty ,Pediatrics ,030231 tropical medicine ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Risk Factors ,medicine ,Humans ,Syphilis ,030212 general & internal medicine ,Pregnancy Complications, Infectious ,business.industry ,Obstetrics ,Syphilis, Congenital ,Incidence (epidemiology) ,Infant, Newborn ,Absolute risk reduction ,Infant ,Odds ratio ,medicine.disease ,Infectious Disease Transmission, Vertical ,Confidence interval ,Anti-Bacterial Agents ,Infectious Diseases ,Congenital syphilis ,Penicillin G Benzathine ,Female ,business ,Maternal syphilis - Abstract
Background Early screening for syphilis among pregnant women and the effective treatment of maternal syphilis is fundamental to prevent congenital syphilis (CS). Methods We obtained data from the Shenzhen Program for Prevention of CS (SPPCS) and estimated incidence rates of CS among infants born to syphilis-seropositive women treated with different regimens or untreated for maternal syphilis. Results A total of 4746 matched cases of syphilis-seropositive mothers and their infants were included for analyses, and 162 infants were diagnosed with CS, providing an overall incidence of 3.41% (95% confidence interval [CI], 2.91%-3.98%). Among infants born to syphilis-seropositive women who had syphilis and were adequately treated before pregnancy, the incidence was 0.22% (95% CI, .05%-.66%). There were 159 cases of CS occurring in 3519 infants born to women who were syphilis-seropositive during their pregnancies, for an incidence of 4.52% (95% CI, 3.84%-5.28%). The incidence of CS was 1.82%-11.90% lower among infants born to the women treated with early benzathine penicillin G (BPG) compared with those treated with late BPG (adjusted odds ratio [aOR], 8.06 [95% CI, 2.93-22.21]; P < .001), other antibiotics (aOR, 7.71 [95% CI, .86-69.28]; P = .068), or those untreated (aOR, 68.28 [95% CI, 29.64-157.28]; P < .001). The incidence rates were 0.22% (95% CI, .06%-.80%) and 0.59% (95% CI, .35%-1.02%) in infants born to women treated with 2 courses and 1 course of BPG, respectively, corresponding to a risk difference of 0.37% (aOR, 1.74; 95% CI, .37-8.26). Conclusions Treatment of syphilis-seropositive pregnant women with 1 course of intramuscular BPG before 28 gestational weeks is critical for prevention of CS.
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- 2017
14. Congenital syphilis: an economic evaluation of a prevention program in China
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Fu-Chang, Hong, Jiang-Bo, Liu, Tie-Jian, Feng, Xiao-Li, Liu, Peng, Pan, Hua, Zhou, Yu-Mao, Cai, Li, Ling, Xi-Ming, Huang, Dan, Zhang, Ying-Ji, Zhang, and Zeegers, Maurice P.
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Syphilis -- Prevention ,Syphilis -- Risk factors ,Medical screening -- Usage ,Wellness programs -- Usage ,Health - Abstract
Background: Until now there has been no data to show the effectiveness or benefits of screening for syphilis in gravidas in China. This study was to assess the effectiveness of a program preventing mother-to-child-transmission of syphilis and to reveal factors impacting the benefit. Methods: A cohort of 159,017 gravidas were screened for syphilis by serologic methods and infected individuals were treated with 3 injections of 2.4 million units of benzathine penicillin in Shenzhen in 2005. The pregnancy outcomes were compared for this cost-effectiveness analysis in 2 scenarios, intervention with screening and treatment versus no intervention. Results: Eight hundred twenty-seven pregnant women (0.52%) were diagnosed with syphilis and treated subsequently. Of these, 200 gestations ended in miscarriage. Four babies were diagnosed with congenital syphilis; 25 neonates with low birth weight; 1 died after birth. The total cost was $636,748. On average, every $770 identified 1 infected mother. Every $4391 prevented 1 congenital syphilis; every $5135 prevented 1 low birth weight; and every $7075 prevented 1 death. One disability adjusted life year could be saved by $215. In total the program reached a benefit to cost ratio of 21.76. Sensitivity analyses revealed that this ratio was mainly impacted by the prevalence of syphilis in pregnant women and the rate of miscarriage. DOI: 10.1097/OLQ.0b013e3181b3915b
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- 2010
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15. Chlamydia trachomatis infection among patients attending sexual and reproductive health clinics: A cross-sectional study in Bao'an District, Shenzhen, China
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Tie-Jian Feng, Qin-Ying Fan, Yu-Mao Cai, Rui-lin Yan, Zhi-ming Huang, Li-mei Li, Gui-chun Wen, Yun-Feng Ye, and Yan-Hui Huang
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Male ,Health Screening ,Cross-sectional study ,Epidemiology ,Physiology ,Chlamydia trachomatis ,Urine ,medicine.disease_cause ,Ambulatory Care Facilities ,Chlamydia Infection ,Geographical Locations ,Gonorrhea ,0302 clinical medicine ,Odds Ratio ,Prevalence ,Medicine and Health Sciences ,Medicine ,Public and Occupational Health ,030212 general & internal medicine ,Young adult ,Health Systems Strengthening ,Reproductive health ,0303 health sciences ,Multidisciplinary ,Obstetrics ,Obstetrics and Gynecology ,Middle Aged ,Body Fluids ,Reproductive Health ,Infectious Diseases ,Female ,Anatomy ,Nucleic Acid Amplification Techniques ,Research Article ,Adult ,DNA, Bacterial ,medicine.medical_specialty ,China ,Asia ,Adolescent ,Science ,Sexually Transmitted Diseases ,03 medical and health sciences ,Young Adult ,Humans ,Health Care Policy ,030306 microbiology ,business.industry ,Biology and Life Sciences ,Nucleic acid amplification technique ,Odds ratio ,Chlamydia Infections ,Confidence interval ,Neisseria gonorrhoeae ,Health Care ,Cross-Sectional Studies ,Logistic Models ,Medical Risk Factors ,People and Places ,Women's Health ,business - Abstract
This study aimed to estimate the prevalence of chlamydial trachomatis (CT) infection and explore its risk factors among patients attending sexual and reproductive health clinics in Shenzhen, China. We collected demographic and clinical information from attendees (aged 18-49). CT and Neisseria gonorrhoeae (NG) infection was determined by nucleic acid amplification test (NAAT) on self-collected urine specimens. Of 1,938 participants recruited, 10.3% (95% confidence interval [CI]: 9.6%-11.0%) tested positive for CT. Prevalence was similar between men (10.6% [85/804]; 95% CI, 9.5%-11.7%) and women (10.1% [115/1134]; 95% CI: 9.2%-11.0%). Being 18-25 years old (adjusted odds ratio [aOR] = 2.52; 95%CI:1.35-4.71), never tested for CT before (aOR = 2.42; 95%CI: 1.05-5.61) and infected with NG(aOR = 3.87; 95%CI: 2.10-7.10) were independently associated with CT infection. We found that CT infection is prevalent among patients attending sexual and reproductive health clinics in Shenzhen, China. A comprehensive program including CT screening, surveillance and treatment is urgently needed.
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- 2018
16. Reported prevalence of childhood maltreatment among Chinese college students: A systematic review and meta-analysis
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Tingting Wang, Xiaobing Wu, Tubao Yang, Jiabi Qin, Lina Lan, Yu-Mao Cai, Tie-Jian Feng, and Hanlin Fu
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Child abuse ,Male ,Questionnaires ,Epidemiology ,Emotions ,lcsh:Medicine ,Social Sciences ,Criminology ,Pediatrics ,Database and Informatics Methods ,0302 clinical medicine ,Mathematical and Statistical Techniques ,Sociology ,Prevalence ,Medicine and Health Sciences ,Psychology ,Public and Occupational Health ,030212 general & internal medicine ,Child Abuse ,Database Searching ,lcsh:Science ,Psychological abuse ,Child ,Multidisciplinary ,Child and Adolescent Health Policy ,Adult Survivors of Child Abuse ,05 social sciences ,Traumatic Injury Risk Factors ,Statistics ,Metaanalysis ,Research Assessment ,Systematic review ,Physical abuse ,Research Design ,Meta-analysis ,Physical Sciences ,Female ,Crime ,050104 developmental & child psychology ,Research Article ,China ,Adolescent ,Universities ,Systematic Reviews ,Psychometrics ,MEDLINE ,Research and Analysis Methods ,03 medical and health sciences ,Humans ,0501 psychology and cognitive sciences ,Statistical Methods ,Students ,Survey Research ,Health Care Policy ,lcsh:R ,Biology and Life Sciences ,Publication bias ,Child Abuse, Sexual ,Health Care ,Sexual abuse ,Medical Risk Factors ,lcsh:Q ,Mathematics ,Demography - Abstract
Objective To estimate the prevalence of childhood maltreatment among college students in China by a systematic review and meta-analysis. Methods A systematic search of relevant articles in Pubmed, Wanfang Data, Chinese Scientific Journals Fulltext Database (CQVIP), China National Knowledge Infrastructure (CNKI) and China Biology Medicine disc (CBMdisc) was conducted on September 1, 2017. A random-effects model was used to estimate the pooled prevalence and sources of heterogeneity were explored using subgroup analyses. Results In total, 32 studies were included in our review. The pooled prevalence of childhood maltreatment among college students was 64.7% (CI: 52.3%-75.6%). For childhood physical abuse(CPA), childhood emotional abuse(CEA), childhood sexual abuse(CSA), childhood physical neglect(CPN)and childhood emotional neglect (CEN), the pooled estimates were 17.4% (13.8%-21.3%), 36.7%(25.1%-49.1%), 15.7%(11.6%-20.2%), 54.9%(41.2%-68.1%) and 60.0% (45.0%-74.0%), respectively. Use of the Childhood Trauma Questionnaire (CTQ) yielded a higher pooled estimate than any other measurement tools in the subgroup analyses of CPA, CEA, CSA, CPN and CEN. The Egger’s tests revealed no evidence of publication bias(P>0.05). Conclusions Childhood maltreatment is common among college students in China. Prevention policies and programmes should be urgently developed to stop the occurrence of child maltreatment, and special attention should be paid to maltreated college students.
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- 2018
17. Population-based study of chlamydial and gonococcal infections among women in Shenzhen, China: Implications for programme planning
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Xiaobing Wu, Xiang-Sheng Chen, Li Zhang, Qiuhong Wu, Fu-Chang Hong, Yu-Mao Cai, Zhongwei Chen, Lishan Tian, Min Zhang, Lan-Lan Liu, Wu Li, Lina Lan, Zhenzhou Luo, Tie-Jian Feng, Jun Yuan, and Yi Ding
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0301 basic medicine ,medicine.medical_specialty ,030106 microbiology ,Population ,Gonorrhea ,lcsh:Medicine ,medicine.disease_cause ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Condom ,law ,medicine ,030212 general & internal medicine ,Young adult ,education ,lcsh:Science ,education.field_of_study ,Multidisciplinary ,Chlamydia ,business.industry ,Obstetrics ,lcsh:R ,Odds ratio ,medicine.disease ,Confidence interval ,lcsh:Q ,business ,Chlamydia trachomatis - Abstract
This study was aimed to estimate the prevalences of chlamydia (CT) and gonococcal (NG) infections and explore risk factors associated with the CT infection among women in Shenzhen, China. We collected socio-demographic and clinical data from women (aged 20-60) and determined positivity of CT or NG by nucleic acid amplification test (NAAT) with self-collected urine specimens. We estimated prevalence of CT and NG and determined risk factors associated with CT infection. Among 9,207 participants, 4.12% (95% confidence interval [CI], 3.71%-4.53%) tested positive for CT and 0.17% (95% CIs, 0.09%-0.25%) for NG. Factors significantly associated with CT infection included being an ethnic minority (ethnicity other than Han China) (Adjusted odds ratio [AOR], 1.9; 95% CI, 1.2-3.0), using methods other than condom for contraception (AOR, 1.5; 95% CI, 1.2-1.8), having a history of adverse pregnancy outcomes (AOR, 1.4; 95% CI, 1.1-1.8), and experiencing reproductive tract symptoms in the past three months (AOR, 1.3; 95% CI, 1.0-1.7). we found that CT infection is prevalent among women in Shenzhen, China and associated with both demographic and behavioral factors. A comprehensive CT screening, surveillance and treatment programme targeting this population is warranted.
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- 2018
18. Analysis of the Association between Catechol-O-Methyltransferase Val158Met and Male Sexual Orientation
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Ruiwei Xu, Xiao-Li Liu, Hong Pan, Jing Wang, Shinan Wu, Tie-Jian Feng, Fu-Chang Hong, Feng Wang, Yumao Cai, Binbin Wang, Wei Yu, Guanglu Zhao, and Dan Tu
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Adult ,Male ,Candidate gene ,Genotype ,Urology ,Endocrinology, Diabetes and Metabolism ,Single-nucleotide polymorphism ,Biology ,Catechol O-Methyltransferase ,Polymerase Chain Reaction ,Polymorphism, Single Nucleotide ,Methionine ,Endocrinology ,Asian People ,Polymorphism (computer science) ,Genetic model ,Humans ,Homosexuality, Male ,Allele ,Heterosexuality ,Alleles ,Genetic association ,Genetics ,Catechol-O-methyl transferase ,Valine ,Exons ,Psychiatry and Mental health ,Reproductive Medicine - Abstract
Introduction Male sexual orientation is thought to have a genetic component. However, previous studies have failed to generate positive results from among candidate genes. Catechol-O-methyltransferase (COMT), located on chromosome 22, has six exons, spans 27 kb, and encodes a protein of 271 amino acids. COMT has an important role in regulating the embryonic levels of catecholamine neurotransmitters (such as dopamine, norepinephrine, and epinephrine) and estrogens. COMT is also thought to be related to sexual orientation. Aims This study aimed to investigate the relationship between the COMT Val158Met variant and male sexual orientation. We performed association analysis of the COMT gene single nucleotide polymorphism, Val158Met, in 409 homosexual cases and 387 heterosexual control Chinese men. COMT polymorphism status was determined using a polymerase chain reaction-based assay. Methods Polymerase chain reaction was performed to genotype the COMT Val158Met polymorphism. Main Outcome Measures The frequency differences of the genotype and alleles distribution between the male homosexual and control groups. Results Significant differences, both in genotype and alleles, between male homosexual individuals and controls indicated a genetic component related to male homosexuality. The Val allele recessive model could be an interrelated genetic model of the cause of male homosexuality. Conclusion The COMT Val158Met variant might be associated with male sexual orientation and a recessive model was suggested.
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- 2015
19. Childhood Abuse Experiences and the COMT and MTHFR Genetic Variants Associated With Male Sexual Orientation in the Han Chinese Populations: A Case-Control Study
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Lin Yang, Tie-Jian Feng, Feng Wang, Jiabi Qin, Yumao Cai, Guanglu Zhao, and Lina Lan
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0301 basic medicine ,Adult ,Male ,Urology ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,Sexual Behavior ,Population ,Catechol O-Methyltransferase ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Young Adult ,Endocrinology ,Asian People ,Recall bias ,Odds Ratio ,Medicine ,Humans ,Homosexuality ,Child Abuse ,Prospective Studies ,education ,Child ,Methylenetetrahydrofolate Reductase (NADPH2) ,media_common ,education.field_of_study ,030505 public health ,Polymorphism, Genetic ,biology ,business.industry ,Case-control study ,Odds ratio ,Middle Aged ,Psychiatry and Mental health ,030104 developmental biology ,Reproductive Medicine ,Methylenetetrahydrofolate reductase ,Case-Control Studies ,Sexual orientation ,biology.protein ,0305 other medical science ,business ,Clinical psychology ,rs4680 - Abstract
Background Although it is widely acknowledged that genetic and environmental factors are involved in the development of male homosexuality, the causes are not fully understood. Aim To explore the association and interaction of childhood abuse experiences and genetic variants of the catechol-O-methyltransferase (COMT) and methylenetetrahydrofolate reductase (MTHFR) genes with the development of male homosexuality. Methods A case-control study of 537 exclusively homosexual men and 583 exclusively heterosexual men was conducted, with data collected from March 2013 to August 2015. Data were analyzed using χ2 tests and logistic regression models. Outcomes Sociodemographic characteristics, childhood abuse experiences, and polymorphisms of COMT at rs4680, rs4818, and rs6267 and MTHFR at rs1801133. Results More frequent occurrence of physical (adjusted odds ratio [aOR] = 1.78), emotional (aOR = 2.07), and sexual (aOR = 2.53) abuse during childhood was significantly associated with the development of male homosexuality. The polymorphisms of MTHFR at rs1801133 and COMT at rs4818 also were significantly associated with the development of male homosexuality in the homozygote comparisons (T/T vs C/C at rs1801133, aOR = 1.68; G/G vs C/C at rs4818, aOR = 1.75). In addition, significant interaction effects between childhood abuse experiences and the COMT and MTHFR genetic variants on the development of male homosexuality were found. Clinical Translation This is the first time that an association of childhood abuse, COMT and MTHFR genetic variants, and their interactions with development of male homosexuality was exhaustively explored, which could help provide new insight into the etiology of male homosexuality. Strengths and Limitations Because homosexual men are a relatively obscure population, it was impossible to select the study participants by random sampling, which could lead to selection bias. In addition, because this was a case-control study, recall bias was inevitable, and we could not verify causality. Conclusions Childhood abuse and the COMT and MTHFR genetic variants could be positively associated with the development of homosexuality. However, it remains unknown how these factors jointly play a role in the development of homosexuality, and more studies in different ethnic populations and with a larger sample and a prospective design are required to confirm our findings.
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- 2017
20. Poor awareness of syphilis prevention and treatment knowledge among six different populations in south China
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Lina Lan, Yingzhou Yang, Xiaobing Wu, Fu-Chang Hong, Chunlai Zhang, and Tie-Jian Feng
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Adult ,Male ,China ,Health Knowledge, Attitudes, Practice ,medicine.medical_specialty ,Universities ,Urban Population ,media_common.quotation_subject ,Alternative medicine ,Developing country ,Education ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Pregnancy ,Surveys and Questionnaires ,Epidemiology ,Humans ,Medicine ,Syphilis ,030212 general & internal medicine ,Homosexuality ,Homosexuality, Male ,Students ,Socioeconomics ,media_common ,Sex Workers ,030505 public health ,Traditional medicine ,business.industry ,lcsh:Public aspects of medicine ,Public health ,Age Factors ,Public Health, Environmental and Occupational Health ,lcsh:RA1-1270 ,Awareness ,medicine.disease ,Knowledge ,Socioeconomic Factors ,Female ,Pregnant Women ,Biostatistics ,0305 other medical science ,business ,Research Article - Abstract
Background China is facing an emerging epidemic of syphilis, and the cities in south China are most affected. Knowledge is a key factor in the prevention of syphilis infection, however, little is reported about how much people know about syphilis. This study was aimed at assessing peoples’ awareness status in a city located in south China. Methods Six populations were recruited for this study, including urban residents, factory workers, college students, pregnant women, female sex workers (FSWs), and men who have sex with men (MSM). A questionnaire designed by the National Center for Disease Control and Prevention was used to assess participants’ awareness of syphilis knowledge. About 5 % of participants were randomly selected to conduct a telephone survey for confirming the validity of fieldwork. Results The study recruited 3470 participants, and 61.2 % of participants were assigned to the awareness group. College students had the smallest percentage of awareness at 51.7 % (371/718), followed by FSWs at 53.9 % (200/371), factory workers at 56.0 % (381/679), urban residents at 65.4 % (435/665), pregnant women at 66.0 % (451/683), and MSM at 81.1 % (287/354). Multivariate logistic regression analysis showed that MSM and FSWs—but not factory workers and pregnant women—had more awareness of syphilis knowledge when comparing with urban residents; however, college students presented less awareness of syphilis knowledge than urban residents. Participants of younger age, of female gender, with lower education levels and without Shenzhen hukou possessed less awareness of syphilis knowledge than those of older age, of male gender, with higher education levels and with Shenzhen hukou respectively. Conclusions The percentages of awareness on syphilis knowledge found in this study are far from the benchmark set in the national 10-year plan. Tailored interventions for different subgroups to increase syphilis awareness are urgently warranted. Electronic supplementary material The online version of this article (doi:10.1186/s12889-016-2966-4) contains supplementary material, which is available to authorized users.
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- 2016
21. Prevalence of Anorectal Chlamydia trachomatis Infection and Its Genotype Distribution among Men Who Have Sex with Men in Shenzhen, China
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Jian-Hong Li, Yu-Mao Cai, Yue-Ping Yin, Fu-Chang Hong, Mei-Qin Shi, Tie-Jian Feng, Rui-Rui Peng, Bao-Xi Wang, and Xiang-Sheng Chen
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Microbiology (medical) ,Infectious Diseases ,General Medicine - Published
- 2011
22. Congenital syphilis: refining newborn evaluation and management in Shenzhen, southern China
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Li-Xia Qiu, Li-Shan Tian, Li-Jun Lin, Tie-Jian Feng, Da-Dong Wu, Xiao-Li Liu, and Fu-Chang Hong
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Adult ,Sexually transmitted disease ,China ,Pediatrics ,medicine.medical_specialty ,Dermatology ,urologic and male genital diseases ,Sensitivity and Specificity ,Rapid plasma reagin ,Neonatal Screening ,Pregnancy ,Prenatal Diagnosis ,medicine ,Humans ,Pregnancy Complications, Infectious ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Incidence ,Syphilis, Congenital ,Incidence (epidemiology) ,Infant, Newborn ,Retrospective cohort study ,medicine.disease ,Infectious Disease Transmission, Vertical ,Syphilis Serodiagnosis ,Infectious Diseases ,Congenital syphilis ,Female ,Syphilis ,business ,Treponematosis - Abstract
Introduction Consistent definitions of congenital syphilis are critical for determining true incidences and setting up targets of elimination. This study aimed to assess the evaluation and management of infants at high risk of congenital syphilis with an antenatal syphilis-screening programme in the Shenzhen SEZ and to develop feasible definitions for the detection of congenital syphilis in China. Methods A retrospective study was conducted of all standardised records of pregnant women with positive syphilis between 2003 and 2007. Infants at high risk of congenital syphilis were evaluated by laboratory tests at birth and longitudinal follow-up. A screening test-positive congenital syphilis case was defined based on a positive 19S-IgM-FTA-ABS result at birth. Assuming that 19S-IgM-FTA-ABS was the gold standard, the sensitivity and specificity of the ascertainment methods were calculated. Results During the study period, 1010 live infants were born to women with active syphilis during pregnancy. 19S-IgM-FTA-ABS detected 42 screening-positive congenital syphilis cases and another nine cases were identified by longitudinal follow-up only. Using 19S-IgM-FTA-ABS as the gold standard, ‘fourfold rapid plasma reagin (RPR) titres’ had the highest sensitivity and specificity compared with the other two follow-up methods. Discussion 19S-IgM-FTA-ABS makes congenital syphilis case classification simpler and faster for newborns. In areas where 19S-IgM-FTA-ABS is not available, comparing newborn RPR titres with maternal titres can be an alternative method. Meanwhile, positive follow-up results act as treatment indicators for older infants. As congenital syphilis definitions vary over the country, the Shenzhen programme suggested a practical model for surveillance and treatment in areas with or without available 19S-IgM-FTA-ABS testing.
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- 2010
23. Congenital syphilis: an economic evaluation of a prevention program in China
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Hua Zhou, Ying-ji Zhang, Xiao-Li Liu, Xi-Ming Huang, Li Ling, Fu-Chang Hong, Jiang-Bo Liu, Yumao Cai, Dan Zhang, Tie-Jian Feng, Maurice P. Zeegers, Peng Pan, Complexe Genetica, RS: NUTRIM - R4 - Gene-environment interaction, and Genetica & Celbiologie
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Microbiology (medical) ,Sexually transmitted disease ,China ,Pediatrics ,medicine.medical_specialty ,Cost-Benefit Analysis ,Dermatology ,Pregnancy ,Environmental health ,medicine ,Humans ,Mass Screening ,business.industry ,Syphilis, Congenital ,Infant, Newborn ,Pregnancy Outcome ,Public Health, Environmental and Occupational Health ,Prenatal Care ,Health Care Costs ,medicine.disease ,Infectious Diseases ,Congenital syphilis ,Cohort ,Economic evaluation ,Female ,Syphilis ,business ,Treponematosis ,Models, Econometric ,Beta lactam antibiotics - Abstract
BACKGROUND: Until now there has been no data to show the effectiveness or benefits of screening for syphilis in gravidas in China. This study was to assess the effectiveness of a program preventing mother-to-child-transmission of syphilis and to reveal factors impacting the benefit. METHODS: A cohort of 159,017 gravidas were screened for syphilis by serologic methods and infected individuals were treated with 3 injections of 2.4 million units of benzathine penicillin in Shenzhen in 2005. The pregnancy outcomes were compared for this cost-effectiveness analysis in 2 scenarios, intervention with screening and treatment versus no intervention. RESULTS: Eight hundred twenty-seven pregnant women (0.52%) were diagnosed with syphilis and treated subsequently. Of these, 200 gestations ended in miscarriage. Four babies were diagnosed with congenital syphilis; 25 neonates with low birth weight; 1 died after birth. The total cost was $636,748. On average, every $770 identified 1 infected mother. Every $4391 prevented 1 congenital syphilis; every $5135 prevented 1 low birth weight; and every $7075 prevented 1 death. One disability adjusted life year could be saved by $215. In total the program reached a benefit to cost ratio of 21.76. Sensitivity analyses revealed that this ratio was mainly impacted by the prevalence of syphilis in pregnant women and the rate of miscarriage. CONCLUSIONS: Screening for antenatal syphilis combined with intervening during gestation is highly effective in China. Reducing the percentage of spontaneous/induced abortion would be one of the most effective methods of further increasing the benefits of this screening.
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- 2010
24. Short Communication:SDF1-3′A Gene Mutation Is Correlated with Increased Susceptibility to HIV Type 1 Infection by Sexual Transmission in Han Chinese
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Tie-jian Feng, Xiang-dong Shi, Xiaohui Wang, Shaofa Nie, Jinquan Cheng, Yueyun Wang, Jin Zhao, Lin Chen, Ji Peng, and Guang-lu Zhao
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Adult ,Male ,Sexually transmitted disease ,China ,Sexual transmission ,Adolescent ,Genotype ,Immunology ,HIV Infections ,Biology ,Asian People ,Gene Frequency ,Acquired immunodeficiency syndrome (AIDS) ,Polymorphism (computer science) ,Virology ,medicine ,Humans ,Genetic Predisposition to Disease ,Allele ,Allele frequency ,Polymorphism, Genetic ,virus diseases ,Middle Aged ,medicine.disease ,Chemokine CXCL12 ,Cross-Sectional Studies ,Infectious Diseases ,Mutation ,HIV-1 ,Female ,Restriction fragment length polymorphism ,Polymorphism, Restriction Fragment Length - Abstract
Limited information is available on host genetic polymorphisms that confer resistance to HIV-1 infection in Han Chinese who persistently remain seronegative (HEPS) despite high exposure to HIV-1 through unprotected sexual activity with known HIV-1-seropositive spouses or long-term sexual partners. The aim of this study was to investigate the correlation of CCR5-Delta32, CCR2b-64I, and SDF1-3'A polymorphisms with susceptibility to HIV-1 infection through sexual transmission in Han Chinese. A cross-sectional study was used to analyze the differences in allelic frequencies of CCR5-Delta32, CCR2b-64I, and SDF1-3'A among HEPS, healthy HIV-unexposed individuals, and HIV-1-seropositive individuals. Restriction fragment length polymorphism (RFLP) analysis was used for genotype determination. The CCR5-Delta32 mutation was not detected in the three groups (n = 260). The allelic frequencies of CCR2b-64I were 21.57%, 21.63%, and 22.12% in the three groups, respectively. There was no significant difference among the three groups in CCR2b-64I distribution. The allelic frequencies of SDF1-3'A were 20.19%, 28.37%, and 29.33% in the three groups, respectively. There was a significant difference in the allelic distribution of SDF1-3'A between HEPS and healthy HIV-unexposed individuals (p = 0.023), as well as between HEPS and HIV-1-seropositive individuals (p = 0.049). Statistical analysis showed that the allelic distributions on CCR2b-64I and SDF1-3'A were in equilibrium according to the Hardy-Weinberg equation. The mutant genotypes of CCR5-Delta32 and CCR2b-64I were not correlated with HIV-1 infection through sexual transmission in Han Chinese. SDF1- 3'A was associated with a high risk of HIV-1 infection through sexual transmission in Han Chinese.
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- 2008
25. Additional file 1: of A preliminary validation of the Brief COPE instrument for assessing coping strategies among people living with HIV in China
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Su, Xiao-You, Lau, Joseph, Mak, Winnie, KC Choi, Tie-Jian Feng, Chen, Xi, Chu-Liang Liu, Liu, Jun, Liu, De, Chen, Lin, Song, Jun-Min, Zhang, Yan, Guang-Lu Zhao, Zhu, Zhang-Ping, and Cheng, Jin-Quan
- Abstract
Multilingual abstracts in the six official working languages of the United Nations. (PDF 204 kb)
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- 2015
- Full Text
- View/download PDF
26. Population Survey of CCR5 Δ32, CCR5 m303, CCR2b 64I, and SDF1 3´A Allele Frequencies in Indigenous Chinese Healthy Individuals, and in HIV-1-Infected and HIV-1-Uninfected Individuals in HIV-1 Risk Groups
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Zhe Wang, Lei Jin, Weiguo Hong, Dongping Xu, Yunzhen Cao, Jun-Jie Ye, Cheryl A. Winkler, Zhou-yun Lei, Liang-Ping Hu, Bo Wang, Zheng-Dong Liu, Tie-Jian Feng, Lin Peng, Jing Hou, Ming Shi, Ming-Xu Liu, Bing Zhang, Ya Qiu, and Fu-Sheng Wang
- Subjects
Adult ,China ,Sexual transmission ,Genotype ,Receptors, CCR5 ,Receptors, CCR2 ,Population ,HIV Infections ,Cohort Studies ,Gene Frequency ,Acquired immunodeficiency syndrome (AIDS) ,Risk Factors ,Polymorphism (computer science) ,Disease Transmission, Infectious ,Ethnicity ,Humans ,Medicine ,Pharmacology (medical) ,Genetic Testing ,Allele ,Substance Abuse, Intravenous ,education ,Allele frequency ,Chemokine CCL2 ,education.field_of_study ,business.industry ,virus diseases ,Middle Aged ,medicine.disease ,Chemokine CXCL12 ,Infectious Diseases ,Population Surveillance ,Mutation ,Immunology ,Cohort ,HIV-1 ,Receptors, Chemokine ,business ,Chemokines, CXC - Abstract
The aim of this study is to determine in indigenous Chinese ethnic groups the frequencies of the chemokine (SDF1 3'A) and chemokine receptors (CCR5 delta32, CCR5 m303, and CCR2b 64I) HIV-1/AIDS restriction alleles. The study includes two cohorts; the first comprised 3165 indigenous healthy subjects representing eight ethnic groups: Han (n = 1406), Uygur (n = 316), Mongolia (n = 134), Hui (n = 386), Tibetan (n = 330), Zhuang (n = 378), Dai (n = 101), and Jingbo (n =114). The second cohort consisted of 330 HIV-1-infected (86 subjects infected by sexual transmission and 198 subjects infected by HIV-1-contaminated blood or by sharing injection equipment; the remaining 46 subjects said nothing about HIV-1 transmission) and 474 HIV-1-uninfected Han Chinese belonging to one of two HIV-1 high-risk groups: intravenous drug users (n = 215) and individuals with sexually transmitted diseases (n = 259). Genotypes for the four genes were obtained using PCR (CCR5 delta32) or PCR-restriction fragment length polymorphism. Randomly selected amplified PCR products were further confirmed by direct DNA sequencing. The variant allele frequencies were determined to be 0% to 3.48% for CCR5 delta32, 0% for CCR5 m303, 16.23% to 28.79% for CCR2b 64I, and 17.70% to 27.76% for SDF1 3'A in Chinese healthy individuals from eight ethnic groups. These findings show that allele frequencies differ among the eight Chinese ethnic groups for CCR5 delta32, CCR2b 64I, and SDF1 3'A and that the CCR5 m303 and CCR5 delta32 mutant alleles were absent or infrequent in Chinese, which may be helpful for studies of specific anti-HIV-1 vaccine trials and coreceptor inhibitor drug targets in Chinese populations. Furthermore, we observed no significant differences in allele or genotypic frequencies between HIV-1-infected and HIV-1-uninfected groups from the Han ethnic group. Our finding is the first reporting that there is likely no effect of the examined polymorphisms in our study on HIV-1 transmission in the Chinese Han population, However, the genetic effects of these and other AIDS-modifying polymorphisms on the pathogenesis and clinical outcome of HIV-1/AIDS diseases is under investigation in Chinese populations.
- Published
- 2003
27. Reduction in mother-to-child transmission of syphilis for 10 years in Shenzhen, China
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Chun-lai Zhang, Mian-Zhi Yao, Jiang-Bo Liu, Xiao-Li Liu, Fu-Chang Hong, Tie-Jian Feng, Lina Lan, Hua Zhou, and Yingzhou Yang
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Microbiology (medical) ,Adult ,Male ,Pediatrics ,medicine.medical_specialty ,China ,Population ,Developing country ,Mothers ,Dermatology ,Pregnancy ,Preventive Health Services ,medicine ,Humans ,Syphilis ,Cooperative Behavior ,Pregnancy Complications, Infectious ,education ,education.field_of_study ,Transmission (medicine) ,business.industry ,Incidence (epidemiology) ,Incidence ,Syphilis, Congenital ,Public Health, Environmental and Occupational Health ,Infant, Newborn ,Pregnancy Outcome ,Prenatal Care ,medicine.disease ,Infectious Disease Transmission, Vertical ,Anti-Bacterial Agents ,Government Programs ,Low birth weight ,Infectious Diseases ,Congenital syphilis ,Penicillin G Benzathine ,Female ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Untreated maternal syphilis can result in the fetuses being infected. Severe adverse pregnancy outcomes include stillbirth, perinatal death, low birth weight, and congenital syphilis (CS). The World Health Organization has already classified global elimination of CS as a priority. However, this preventable disease is still threatening people's health in the world.A Programme of Prevention of Mother-to-Child Transmission of Syphilis in Shenzhen was launched in 2002. All pregnant women in Shenzhen were screened for syphilis by serological methods at their first prenatal care visit. The infected individuals were treated with 3 weekly injections of 2.4 million units of benzathine penicillin. The babies were followed up until 18 months old to diagnose CS.Up to 2011, the Programme of Prevention of Mother-to-Child Transmission of Syphilis in Shenzhen screened 2,077,362 pregnant women and intervened in 7668 mothers infected with syphilis. The screened rate among pregnant women increased from 89.8% in 2002 to 97.4% in 2011. The proportion of those having adverse pregnant outcomes (including spontaneous abortion, premature delivery, and stillbirth) decreased from 27.3% in 2003 to 8.2% in 2011. The incidence of CS decreased from 115/100,000 in 2002 to 10/100,000 (live births) in 2011.In 2002, in the face of rising CS numbers, Shenzhen adapted a syphilis control program that involved cost-free testing for pregnant women, commitment and collaboration at multiple levels of the health system, and strong supervision and government guidance. Local program and surveillance data suggest that the program has been very successful in reducing CS incidence.
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- 2014
28. Reported estimates of adverse pregnancy outcomes among women with and without syphilis: a systematic review and meta-analysis
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Hongzhuan Tan, Tie-Jian Feng, Jiabi Qin, Tubao Yang, Shuiyuan Xiao, and Hanlin Fu
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Pediatrics ,medicine.medical_specialty ,Clinical Research Design ,Epidemiology ,Birth weight ,lcsh:Medicine ,Dermatology ,Research and Analysis Methods ,Miscarriage ,Pregnancy ,medicine ,Medicine and Health Sciences ,Humans ,Syphilis ,lcsh:Science ,Multidisciplinary ,Obstetrics ,business.industry ,lcsh:R ,Pregnancy Outcome ,Obstetrics and Gynecology ,Publication bias ,medicine.disease ,Low birth weight ,Congenital syphilis ,Infectious Diseases ,Research Design ,Meta-analysis ,Case-Control Studies ,Women's Health ,Female ,lcsh:Q ,medicine.symptom ,business ,Research Article - Abstract
Background To estimate probability of adverse pregnancy outcomes (APOs) among women with and without syphilis through a systematic review of published literatures. Methodology/Principal Findings Chinese and English literatures were searched for studies assessing pregnancy outcomes in the presence of maternal syphilis through August 2013. The prevalence estimates were summarized and analyzed by meta-analysis. Fifty-four literatures involving 11398 syphilitic women and 43342 non-syphilitic women were included from 4187 records initially found. Among untreated mothers with syphilis, pooled estimates were 76.8% for all APOs, 36.0% for congenital syphilis, 23.2% for preterm, 23.4% for low birth weight, 26.4% for stillbirth or fetal loss, 14.9% for miscarriage and 16.2% for neonatal deaths. Among syphilitic mother receiving treatment only in the late trimester (>28 weeks), pooled estimates were 64.4% for APOs, 40.6% for congenital syphilis, 17.6% for preterm, 12.4% for low birth weight, and 21.3% for stillbirth or fetal loss. Among syphilitic mothers with high titers (≥1∶8), pooled estimates were 42.8% for all APOs, 25.8% for congenital syphilis, 15.1% for preterm, 9.4% for low birth weight, 14.6% for stillbirth or fetal loss and 16.0% for neonatal deaths. Among non-syphilitic mothers, the pooled estimates were 13.7% for all APOs, 7.2% for preterm birth, 4.5% for low birth weight, 3.7% for stillbirth or fetal loss, 2.3% for miscarriage and 2.0% for neonatal death. Begg's rank correlation test indicated little evidence of publication bias (P>0.10). Substantial heterogeneity was found across studies in the estimates of all adverse outcomes for both women with syphilis (I2 = 93.9%; P
- Published
- 2014
29. Risk factors for congenital syphilis and adverse pregnancy outcomes in offspring of women with syphilis in Shenzhen, China: a prospective nested case-control study
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Keita Mamady, Fuchang Hong, Tie-Jian Feng, Chun-lai Zhang, Willa Dong, Jiabi Qin, Lina Lan, Tu-Bao Yang, and Fan Yang
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Microbiology (medical) ,Adult ,medicine.medical_specialty ,China ,Health Knowledge, Attitudes, Practice ,Population ,Dermatology ,Prenatal care ,Pregnancy ,Risk Factors ,Prenatal Diagnosis ,Infant Mortality ,medicine ,Odds Ratio ,Childbirth ,Humans ,Mass Screening ,Prospective Studies ,Pregnancy Complications, Infectious ,education ,Substance Abuse, Intravenous ,Gynecology ,education.field_of_study ,Obstetrics ,business.industry ,Syphilis, Congenital ,Public Health, Environmental and Occupational Health ,Infant, Newborn ,Pregnancy Outcome ,Prenatal Care ,medicine.disease ,Low birth weight ,Infectious Diseases ,Congenital syphilis ,Logistic Models ,Premature birth ,Case-Control Studies ,Syphilis ,Female ,medicine.symptom ,business ,Maternal Age - Abstract
Despite existence of a highly effective intervention, maternal syphilis still causes substantial perinatal morbidity and mortality, even in China, where antenatal health services are strong. This study sought to address personal, programmatic, and other risk factors for congenital syphilis (CS) and adverse pregnancy outcomes (APOs) among pregnant women in Shenzhen, China.Pregnant women attending antenatal services were offered serologic tests, and those diagnosed as having syphilis were recruited from April 2007 to October 2012. In a nested case-control study for the pregnancy outcomes of syphilis-infected women, we assessed risk factors comparing infants born with CS (group II) and with any APOs (group III) to infants without CS or APOs (group I).During the 66-month study period, we screened 279,334 pregnant women and identified 838 (0.3%; 95% confidence interval, 0.28%-0.32%) women infected with syphilis. Among infants born to syphilitic mothers, 8.2% (34/417) were diagnosed as having CS and 24.7% (103/417) were diagnosed as having APOs. Compared with group I, maternal baseline titers of nontreponemal antibodies (adjusted odds ratio [aOR], 2.13), stage of syphilis (aOR, 21.56), length of time between the end of the first treatment to childbirth (aOR, 11.93), gestational week at treatment (aOR, 2.63), and fathers' cocaine use (aOR, 15.44) and syphilis infection status (aORpositive vs. negative, 5.84; aORunknown vs. negative, 5.55) were positively associated with CS, but prenatal care (aOR, 0.11) and complete treatment (aOR, 0.20) were negatively associated with CS. Maternal age (aOR, 1.43), marriage (aOR, 2.41), history of cocaine use (aOR, 3.79) and ectopic pregnancy (aOR, 5.91), baseline titers of nontreponemal antibodies (aOR, 1.30), stage of syphilis (aOR, 8.89), length of time between the end of the first treatment to childbirth (aOR, 2.52), gestational week at treatment (aOR, 1.78), and fathers' syphilis infection status (aORunknown vs. negative, 2.02) were also positively associated with APOs, but maternal history of syphilis (aOR, 0.44), prenatal care (aOR, 0.29), and complete treatment (aOR, 0.25) were negatively associated with APOs,Syphilis was an important cause of pregnancy loss and infant disability, particularly among women who did not receive prenatal care or had late or inadequate treatment. These study results can inform antenatal programs on the importance of early syphilis testing and prompt and appropriate treatment. Some strategies targeted at other risk factors areas may be helpful.
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- 2013
30. Analysis of the sex ratio of reported gonorrhoea incidence in Shenzhen, China
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Chunlai Zhang, Aizhong Liu, Xiaobing Wu, Lizhang Wen, Guanglu Zhao, Lina Lan, John Best, Mingzhou Xiong, Fuchang Hong, Weiming Tang, Feng Wang, and Tie-Jian Feng
- Subjects
Adult ,Male ,0301 basic medicine ,Sexually transmitted disease ,China ,medicine.medical_specialty ,030106 microbiology ,Population ,Gonorrhea ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,Epidemiology ,medicine ,Humans ,EPIDEMIOLOGY ,Outpatient clinic ,Sex Ratio ,030212 general & internal medicine ,education ,Reproductive health ,Gynecology ,education.field_of_study ,business.industry ,Incidence ,Research ,Incidence (epidemiology) ,General Medicine ,medicine.disease ,Female ,Public Health ,business ,Sex ratio ,Demography - Abstract
Objective To assess the clinical process of gonorrhoea diagnosis and report in China, and to determine the difference of sex ratio between reported incidence based on reporting data and true diagnosis rate based on reference tests of gonorrhoea. Setting A total of 26 dermatology and sexually transmitted disease (STD) departments, 34 obstetrics-gynaecology clinics and 28 urology outpatient clinics selected from 34 hospitals of Shenzhen regarded as our study sites. Participants A total of 2754 participants were recruited in this study, and 2534 participants completed the questionnaire survey and provided genital tract secretion specimens. There were 1106 male and 1428 female participants. Eligible participants were patients who presented for outpatient STD care at the selected clinics for the first time in October 2012 were at least 18 years old, and were able to give informed consent. Outcome measures Untested rate, true-positive rate, false-negative rate and unreported rate of gonorrhoea, as well as reported gonorrhoea incidence sex ratio and true diagnosis sex ratio were calculated and used to describe the results. Results 2534 participants were enrolled in the study. The untested rate of gonorrhoea among females was significantly higher than that among males (female 88.1%, male 68.3%, p=0.001). The male-to-female sex ratios of untested rate, true-positive rate, false-negative rate and unreported rate were 1:1.3, 1.2:1, 1:1.6 and 1:1.4, respectively. The reported gonorrhoea incidence sex ratio of new diagnosed gonorrhoea was 19.8:1 (male vs female: 87/1106 vs 5/1420), while the true diagnosis sex ratio was 2.5:1 (male vs female: 161/1106 vs 84/1420). These data indicate that the sex ratio of reported gonorrhoea incidence has been overestimated by a factor of 7.9 (19.8/2.5). Conclusions We found the current reported gonorrhoea incidence and sex ratios to be inaccurate due to underestimations of gonorrhoea incidence, especially among women.
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- 2016
31. [Primary drug resistance of HIV-1 infected men who have sex with men in Shenzhen, China]
- Author
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Guang-lu, Zhao, Wei, Yu, Yu-mao, Cai, Feng, Wang, Fu-chang, Hong, Wei-na, Jiang, Yong-lai, Li, Yi, Peng, Chun-lai, Zhang, Juan-juan, Zhang, and Tie-jian, Feng
- Subjects
Adult ,Male ,Acquired Immunodeficiency Syndrome ,China ,Drug Resistance, Viral ,HIV-1 ,Humans ,RNA, Viral ,Homosexuality, Male - Abstract
To evaluate the status of drug resistance among treat-naive HIV-1 infected men who have sex with men (MSM) in Shenzhen during the period of 2008 - 2010.Plasma samples of 227 treatment-naive HIV-1 infected MSM were collected in Shenzhen. HIV-1 pol genes (RT and PR) were amplified by nested-polymerase chain reaction (PCR) from RNA. Phylogenetic and drug resistance analyses were performed on the nucleotide sequence data.A total of 164 pol gene sequences were amplified. The prevalence of primary genotypic drug resistance was 14.6%. The overall prevalence of drug-resistant mutations was 22.6%, corresponding to 8.54% for protease inhibitors (PI) minor drug resistance mutation, 1.22% for nucleotide reverse transcriptase inhibitors (NRTI) drug resistance mutation and 13.41% for non-nucleotide reverse transcriptase inhibitors (NNRTI) drug resistance mutation. The prevalence of drug-resistant mutations was 30.88% for CRF01_AE strain and 19.23% for B strain.The prevalence of drug resistance is relatively moderate in the treat-naive HIV-1 infected MSM in Shenzhen. The prevalence of drug-resistant HIV-1 among MSM in Shenzhen should raise a high alert.
- Published
- 2012
32. [Study on the molecular-epidemiological characteristics of HIV-1 in Shenzhen, 1992-2008]
- Author
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Guang-lu, Zhao, Wei, Yu, Juan-juan, Zhang, Lin, Chen, Tie-jian, Feng, Feng, Wang, Fu-chang, Hong, Xiao-hui, Wang, and Qing, Li
- Subjects
Male ,China ,Molecular Epidemiology ,HIV-1 ,Humans ,Female - Abstract
To investigate the epidemiological characteristics of HIV-1 subtype in Shenzhen from 1992 to 2008.489 HIV-1 positive plasma samples were collected from 1992 to 2008 in Shenzhen. HIV-1 env genes were amplified by nested-PCR from RNA. Phylogenetic analysis was performed on data regarding the nucleotide sequence.A total of 464 sequences were amplified and genotyped. Data from this study revealed that CRF01_AE was a predominant HIV-1 subtype in Shenzhen (64.4%, 299/464), followed by subtypes CRF_BC (17.5%, 81/464), B' (14.7%, 68/464) and B (2.4%, 11/464). Subtype C (0.4%, 2/464), A1 (0.2%, 1/464), CRF02_AG (0.2%, 1/464) and CRF06_cpx (0.2%, 1/464) were also prevalent in Shenzhen. CRF01_AE and CRF_BC were predominant among heterosexuals, homosexuals and injection drug users, while B' was predominant among blood donors. Results from phylogenetic tree analysis showed that some of the HIV-1 clusters had been defined in CRF01_AE strains at different time or groups with different transmission routes. Cross-infections were also seen.CRF01_AE was the predominant HIV-1 subtype in Shenzhen while CRF_BC, B, B', C, A1, CRF02_AG and a small amount of CRF06_cpx or recombinant subtypes were prevalent in this city. Different subtypes showed great variation in the process of epidemics.
- Published
- 2012
33. [Progress in research on the biological reason of male homosexuality]
- Author
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Wei, Yu and Tie-jian, Feng
- Subjects
Male ,Endocrinology ,Neurobiology ,Humans ,Homosexuality, Male ,Developmental Biology - Abstract
Male homosexuality is a complex phenomenon which is universal and with unknown causes. Researchers believe that both biological and environmental factors have played a role in its pathogenesis. Researches focusing on genetics, neurobiology, development and endocrinology have made certain progress. In this paper, we have reviewed the biological causes of male homosexuality, which may provide clues for further research in this field.
- Published
- 2012
34. Multilevel and spatial analysis of syphilis in Shenzhen, China, to inform spatially targeted control measures
- Author
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Jane P. Messina, Lina Lan, Michael Emch, Li-Zhang Wen, Joseph D. Tucker, Yu-Feng Hu, Fu-Chang Hong, Xiao-Li Liu, Xiaobing Wu, Chunlai Zhang, and Tie-Jian Feng
- Subjects
Adult ,Male ,China ,Geography ,business.industry ,Dermatology ,Estimating equations ,Secondary syphilis ,Middle Aged ,medicine.disease ,Article ,Health services ,Infectious Diseases ,Neighbourhood level ,Communicable Disease Control ,Medicine ,Cluster Analysis ,Humans ,Syphilis ,Female ,business ,Neighbourhood (mathematics) ,Demography - Abstract
The present study investigates the varied spatial distribution of syphilis cases in Shenzhen, China, and explores the individual-, neighbourhood- and district-level factors affecting the distribution.This study uses spatial analysis and multi-level generalised estimating equations to explore the spatial distribution of reported syphilis cases among individuals in Shenzhen, Guangdong Province, China. The spatial distribution of primary/secondary and latent cases was investigated using the Moran's I-statistic. Primary/secondary syphilis cases were compared with all syphilis cases using a three-level model with individual (n=6496), neighbourhood (n=55) and district (n=6) levels.A total of 6496 syphilis cases were reported in 2009 with 35.8% primary and secondary syphilis cases. Both primary/secondary syphilis cases (Moran's I value=0.33, p0.01) and latent syphilis cases (Moran's I value=0.19, p0.01) showed significant spatial clustering at the neighbourhood level. Adjusting for the number of reporting hospitals, the best model found that the following characteristics were associated with primary/secondary syphilis infection: individuals who are younger in age (p=0.003), male (p0.001), migrant labourers (p=0.047) and those who live in districts with a higher gross domestic product (p0.001).There is substantial clustering of primary and secondary syphilis cases at the neighbourhood level in Shenzhen, suggesting the need for greater STD health service provision in these clustered neighbourhoods. Spatially targeted syphilis control measures may be useful to optimise testing, treatment and partner services.
- Published
- 2012
35. [Epidemic trend and evolution of HIV-1 CRF01_AE strains isolated from 1992 through 2008 in Shenzhen district]
- Author
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Wei, Yu, Guang-lu, Zhao, Juan-juan, Zhang, Lin, Chen, and Tie-jian, Feng
- Subjects
Evolution, Molecular ,Male ,Recombination, Genetic ,Acquired Immunodeficiency Syndrome ,China ,Molecular Epidemiology ,Genotype ,HIV-1 ,Humans ,Female ,Polymerase Chain Reaction - Abstract
To study the prevalent status of CRF01_AE strains of recombinant HIV-1 in Shenzhen and their source of infection in order to predict the epidemic trend and evolution.A total of 489 samples of HIV-1 positive plasma were collected from 1992 to 2008 in Shenzhen. HIV-1 Env genes were amplified by nested-PCR from RNA. Subtype analysis were performed on the nucleotide sequence data. CRF01_AE sequences were analyzed by phylogenetic methods and characterized by calculating the genetic distance.A total of 300 CRF01_AE strain sequences were amplified, accounting for 64.5% of all genotyped samples of all the 465 samples. The CRF01_AE strains of recombinant in 1992 - 1999, 2000 - 2005 and 2006 - 2008 accounted for 56.8% (21/37), 68.4% (78/114) and 64.0% (201/314) of genotyped samples, respectively. And in these three periods of times, 52.4% (11/21), 43.6% (34/78) and 45.8% (92/201) were heterosexually acquired adults; 4.8% (1/21), 0.0% (0/78) and 22.4% (45/201) were homosexually acquired adults; 19.0% (4/21), 51.3% (40/78), 30.8% (62/210) were intravenous drug users, respectively.Phylogenetic tree analysis revealed that HIV samples from different period of time showed distinct aggregation in time and transmission as well as cross infection. The gene divergence rate of CRF01_AE strains in the three different periods of time were (8.783 ± 4.717)%, (11.054 ± 7.141)%, and (13.218 ± 4.080)%, respectively.CRF01_AE is the major epidemic strains in Shenzhen, which is transmitted through heterosexual contact, MSM and intravenous drug users. The gene variation increased gradually as time goes by.
- Published
- 2012
36. Molecular epidemiology of genital Chlamydia trachomatis infection in Shenzhen, China
- Author
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Fu-Chang Hong, Zhenzhou Luo, Lina Lan, Yi Peng, Guang-lu Zhao, Feng Wang, Tie-Jian Feng, Juan-juan Zhang, Xiang-Sheng Chen, Chunlai Zhang, and Xiao-Li Liu
- Subjects
Sexually transmitted disease ,Adult ,Male ,medicine.medical_specialty ,China ,Adolescent ,Genotype ,Chlamydia trachomatis ,Dermatology ,law.invention ,Condoms ,Gonorrhea ,Young Adult ,Condom ,Obstetrics and gynaecology ,law ,Epidemiology ,medicine ,Prevalence ,Humans ,Sex organ ,Aged ,Gynecology ,Molecular Epidemiology ,Chlamydia ,Molecular epidemiology ,Marital Status ,Unsafe Sex ,business.industry ,Chlamydia Infections ,Middle Aged ,medicine.disease ,Infectious Diseases ,Sexual Partners ,Multivariate Analysis ,Female ,business - Abstract
Objective To investigate molecular epidemiology of Chlamydia trachomatis infection among patients recruited from different clinic settings in Shenzhen, China. Methods A total of 2534 patients from the sexually transmitted disease (STD) clinics, obstetrics and gynaecology (OBGYN) clinics and genitourinary medicine (GUM) clinics in 34 hospitals participated in the study. The C trachomatis infection was determined using COBAS Amplicor system. DNA extracted in C trachomatis -positive samples was amplified using a nested PCR based on omp A gene and then genotyped using a microsphere suspension array. Results The overall prevalence of genital C trachomatis infection was 17.7%. The prevalence in patients at STD or GUM clinics was significantly higher than that in patients at OBGYN clinics. Being male (adjusted OR (AOR) 2.5, 95% CI 1.8 to 3.4), having no consistent use of a condom with casual partners in the past 3 months (AOR 1.7, 95% CI 1.1 to 2.8) and having any STD symptoms (AOR 3.3, 95% CI 2.0 to 5.4) were independently associated with C trachomatis infection. Eight genotypes were identified. The most prevalent genotypes were F (22.3%), E (22.0%) and D/Da (12.7%). Other genotypes were G/Ga (8.0%), J (7.3%), K (2.7%), H (2.7%) and I/Ia (0.4%). Eighty-two samples (18.3%) were infected with multiple genotypes. Genotype D/Da among patients from GUM clinics was more common than those from STD or OBGYN clinics. Infections with genotypes G and F were statistically associated with abnormal vaginal discharge (p=0.001) and being married (p=0.014), respectively. Infection with multiple genotypes was more common among patients with a higher income (p=0.011). Conclusion A substantial prevalence of genital C trachomatis infection in Shenzhen suggests the importance of detection and treatment of the infection in high-risk groups.
- Published
- 2012
37. Spatial and Temporal Patterns of Primary Syphilis and Secondary Syphilis in Shenzhen, China
- Author
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Tie-Jian Feng, Li-Zhang Wen, Yu-Feng Hu, Lina Lan, Yan-Shi Mo, Fu-Chang Hong, Peng Pan, Yu-mao Cai, and Zhen-Qiu Sun
- Subjects
medicine.medical_specialty ,Geography ,Scan statistic ,Epidemiology ,Entertainment industry ,medicine ,Primary Syphilis ,Syphilis ,Residence ,Secondary syphilis ,China ,medicine.disease ,Cartography - Abstract
Objective To learn the spatial and temporal patterns of primary syphilis and secondary syphilis in Shenzhen and to provide evidence for carrying out further research on syphilis.Methods Primary syphilis and secondary syphilis cases among residents in Shenzhen between 2005and 2009(n=11 303) were geocoded at street office level (n=55) based on residence at the time of diagnosis. Both spatial and space-time scan statistics were used to identify clusters of street office by using SaTScan software. Results In the purely spatial analyses, clusters were seen in the junction of the Baoan district and Nanshan district (Xinan, Xixiang, Nanshan and Nantou street office) and in the region near Hong Kong (Dongmen, Shekou, and Futian street office), as well as in the other streets where entertainment industry was relatively developed (Longhua, Huafu, Huangbei and Cuizu street office). The clusters had not changed much in the first four years, but nine clusters appeared in 2009.Annually, the most likely clusters were located in Longhua (2005, P≤0.001, RR=3.34), Bamboo (2006, P≤0.001, RR=9.59), Huafu (2007, 2008 years, P≤0.001, RR values were 4.18 and 4.75)and Cuizu (2009, P≤0.001, RR=8.02). In the space-time scan analysis, we found 16 significant clusters, which were similar to the pure spatial analyses. However, regional difference were also found, with the most likely cluster was the Guiyuan street office in 2006. Conclusion Spatial and space-time scan statistics seemed to be effective ways in describing the circular disease clusters. We have had a better understanding on spatial and temporal patterns of primary syphilis and secondary syphilis in Shenzhen through spatial and space-time scan statistics of syphilis surveillance data in the recent years. The changes of spatial and temporal patterns of primary syphilis and secondary syphilis were also described by SaTScan software, which also provided useful reference for the preventive strategies on sexually transmitted diseases as well as on HIV. Useful information was also provided for financial investment and cost-effective studies. Key words: Syphilis; Space-time scan statistic; Epidemiology
- Published
- 2011
38. Association analysis between the tag SNP for sonic hedgehog rs9333613 polymorphism and male sexual orientation
- Author
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Fu-Chang Hong, Xu Ma, Sirui Zhou, Jing Wang, Binbin Wang, Xiao-Li Liu, Feng Wang, Yumao Cai, and Tie-Jian Feng
- Subjects
Male ,medicine.medical_specialty ,Candidate gene ,animal structures ,Genotype ,Urology ,Endocrinology, Diabetes and Metabolism ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,Endocrinology ,Gene Frequency ,Polymorphism (computer science) ,Internal medicine ,medicine ,Humans ,Hedgehog Proteins ,Sonic hedgehog ,Homosexuality, Male ,Heterosexuality ,Genetic association ,Genetics ,Chi-Square Distribution ,Tag SNP ,Phenotype ,Reproductive Medicine ,Case-Control Studies ,embryonic structures ,biology.protein ,Sexual orientation - Abstract
Male sexual orientation has been proposed to have genetic components, but previously suggested candidate genes have all received negative results. The human sonic hedgehog (SHH) gene is located in the 7q36 region, which was linked to male sexual orientation in a previous genome-wide association study. SHH is known to play an important role in embryo patterning, and there is evidence connecting it to sexual orientation. In this study, we performed an association analysis of the SHH tag single nucleotide polymorphism rs9333613 in 361 subjects and 319 Chinese male controls. We find a significant difference in genotype and allele distribution between identified homosexuals and heterosexual control subjects, suggesting that the SHH gene could potentially be associated with male sexual orientation.
- Published
- 2011
39. [Spatial and temporal patterns of primary and secondary syphilis in Shenzhen, China]
- Author
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Yu-Feng, Hu, Zhen-Qiu, Sun, Fu-Chang, Hong, Li-Na, Lan, Peng, Pan, Yan-Shi, Mo, Yu-Mao, Cai, Li-Zhang, Wen, and Tie-Jian, Feng
- Subjects
China ,Spatial Analysis ,Spatio-Temporal Analysis ,Space-Time Clustering ,Cluster Analysis ,Hong Kong ,Humans - Abstract
To learn the spatial and temporal patterns of primary syphilis and secondary syphilis in Shenzhen and to provide evidence for carrying out further research on syphilis.Primary syphilis and secondary syphilis cases among residents in Shenzhen between 2005 and 2009 (n = 11 303) were geocoded at street office level (n = 55) based on residence at the time of diagnosis. Both spatial and space-time scan statistics were used to identify clusters of street office by using SaTScan software.In the purely spatial analyses, clusters were seen in the junction of the Baoan district and Nanshan district (Xinan, Xixiang, Nanshan and Nantou street office) and in the region near Hong Kong (Dongmen, Shekou, and Futian street office), as well as in the other streets where entertainment industry was relatively developed (Longhua, Huafu, Huangbei and Cuizu street office). The clusters had not changed much in the first four years, but nine clusters appeared in 2009. Annually, the most likely clusters were located in Longhua (2005, P ≤ 0.001, RR = 3.34), Bamboo (2006, P ≤ 0.001, RR = 9.59), Huafu (2007, 2008 years, P ≤ 0.001, RR values were 4.18 and 4.75) and Cuizu (2009, P ≤ 0.001, RR = 8.02). In the space-time scan analysis, we found 16 significant clusters, which were similar to the pure spatial analyses. However, regional difference were also found, with the most likely cluster was the Guiyuan street office in 2006.Spatial and space-time scan statistics seemed to be effective ways in describing the circular disease clusters. We have had a better understanding on spatial and temporal patterns of primary syphilis and secondary syphilis in Shenzhen through spatial and space-time scan statistics of syphilis surveillance data in the recent years. The changes of spatial and temporal patterns of primary syphilis and secondary syphilis were also described by SaTScan software, which also provided useful reference for the preventive strategies on sexually transmitted diseases as well as on HIV. Useful information was also provided for financial investment and cost-effective studies.
- Published
- 2010
40. [Molecular epidemiological survey on HIV-1 among the injecting drug users population in Shenzhen]
- Author
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Guang-lu, Zhao, Tie-jian, Feng, Xiao-hui, Wang, Jin, Zhao, Xiang-dong, Shi, Yan, Zhang, Yong-xia, Gan, and Xian-ru, Luo
- Subjects
Drug Users ,Male ,China ,Molecular Epidemiology ,Genotype ,Molecular Sequence Data ,HIV-1 ,Humans ,Female ,HIV Infections ,Phylogeny - Abstract
To study the prevalent status of human immunodeficiency virus-1 (HIV-1) subtypes in IDU (injecting drug users) population in Shenzhen and to study their source of infection in order to predict the epidemic trend and evolution.166 HIV-1 positive plasma from the IDUs was collected from 1996 to 2008. HIV-1 env genes were amplified by nested-PCR from RNA. The C2-V3 regions (450 bp) of HIV-1 env were sequenced for analyses. Phylogenetic analyses were performed on the nucleotide sequence data.Among 166 samples, there were 6 HIV-1 strains including CRF01_AE, CRF08_BC, CRF07_BC 3 circulating recombinant forms (CRFs) and B', C, A1 3 subtypes. Data from the genotype analyses showed that 65.06% (108/166) were CRF01_AE, 19.88% (33/166) were CRF07_BC, 6.02% (10/166) were CRF08_BC, 7.23% (9/166) were subtype B', 0.60% (1/166) were subtype C and 1.20% (2/166) were subtype A1. Phylogenetic tree analysis showed that some of HIV-1 clusters defined in CRF01_AE, CRF07_BC and subtype B' in different time groups. Significant increase of gene distance in CRF01_AE and CRF07_BC strains in the three different periods.CRF01_AE and CRF07_BC were the major epidemic CRF strains among the IDU population in Shenzhen while the subtype B', C, A1 and CRF08_BC were also circulating in IDU population in this region. The variation of all different subtypes was increasing through these years.
- Published
- 2010
41. [Analysis of the tandem-repeat polymorphisms in DC-SIGNR alleles among drug users population with or without HIV/HCV infection]
- Author
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Jin, Zhao, Guang-lu, Zhao, Zen-li, Ma, Xiao-bing, Wu, Tie-jian, Feng, Xiang-dong, Shi, Xiao-hui, Wang, Hui, Wang, and Tuo-fu, Zhu
- Subjects
Adult ,Male ,Polymorphism, Genetic ,Adolescent ,Genotype ,HIV Infections ,Receptors, Cell Surface ,Hepacivirus ,Middle Aged ,Hepatitis C ,Drug Users ,Young Adult ,Gene Frequency ,HIV-1 ,Humans ,Female ,Lectins, C-Type ,Cell Adhesion Molecules ,Alleles - Abstract
To study the distribution of DC-SIGN/DC-SIGNR alleles among drug user (DUs) populations with or without HIV/HCV infection in Shenzhen, and to evaluate the role of these alleles in the construction of genetic resistance to HIV or HCV and screen out the anti-HIV/HCV gene in Shenzhen.All 500 DU blood samples were collected from Shenzhen Detoxification Center, including 313 from injected drug users (IDUs). All samples were screened for HIV and HCV antibody by means of ELISA. The genomic DNA were extracted and amplified by PCR. The neck domain repeat regions of DC-SIGN/DC-SIGNR were sequenced directly from the PCR products to confirm the amplification for some samples and all positive PCR products were analyzed by agarose gel electrophoresis.Of 500 samples, 97 were found HIV positive, all of which were IDUs and HCV positive. The total positive rate of HCV among all HIV negative DU was 57.57% (232/403), and it was 63.89% (138/216) among IDUs; in comparing to the 50.26% (94/187) of DUs with other manners there showed significant difference (chi(2) = 7.61, P = 0.0058). Among HIV + DUs, there was a higher proportion of patient with the DC-SIGNR 5/6 and 5/8 (Fisher's exact, P = 0.043 and P = 0.034) with statistical significance; there was no statistically significant difference between HCV + and HCV-DUs and no significant difference between IDUs and other DUs for the DC-SIGNR polymorphism.The results might indicate that DC-SIGN/DC-SIGNR polymorphism might not influence the susceptibility to HCV. Genotype 5/6 might probably have a relation with HIV infection, but still need further investigation for the low frequency.
- Published
- 2009
42. Prevalence of syphilis and human immunodeficiency virus infections among men who have sex with men in Shenzhen, China: 2005 to 2007
- Author
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Peng Pan, Yumao Cai, Xiang-Sheng Chen, Tie-Jian Feng, Fu-Chang Hong, Xiao-Li Liu, Hua Zhou, and Wei-na Jiang
- Subjects
Microbiology (medical) ,Sexually transmitted disease ,Adult ,Male ,China ,Population ,Context (language use) ,HIV Infections ,Dermatology ,Men who have sex with men ,Interviews as Topic ,Young Adult ,Acquired immunodeficiency syndrome (AIDS) ,Environmental health ,Surveys and Questionnaires ,medicine ,Prevalence ,Humans ,Syphilis ,Homosexuality, Male ,education ,education.field_of_study ,Transmission (medicine) ,business.industry ,Public Health, Environmental and Occupational Health ,virus diseases ,medicine.disease ,Virology ,Health Surveys ,Infectious Diseases ,business ,Treponematosis - Abstract
In China there has been an emerging epidemic of HIV and syphilis infections among men who have sex with men (MSM). Multiple surveys conducted in recent years have shown a high prevalence of syphilis infections among MSM in China. A rapid increase of HIV prevalence has been demonstrated among MSM in some areas including in China. For example the prevalence of HIV had increased from 0.4% in 2004 to 5.8% in 2006 in Beijing China. A high HIV prevalence has also been found among MSM in other Asian countries including Phnom Penn Cambodia (8.9%) Chiang Mai Thailand (15.3%) and Andhra Pradesh India (18.2%). In 2007 homosexual transmission has accounted for 12.2% of the 50000 estimated new HIV infections in China. Risk of HIV transmission is a particular concern in the context of current syphilis epidemic because infection with ulcerative STDs including syphilis has been shown to increase the risk of HIV transmission 3- to 5-fold. HIV may also increase the acquisition of other STDs and alter the natural history and response to standard therapy of ulcerative STDs resulting in an epidemiologic synergy between HIV and STDs. For these reasons there is particular concern about the potentially increasing transmission of HIV and syphilis among MSM. Because of overlaps in sexual networks between the MSM and non-MSM population it is also predicted that the transmission of HIV and syphilis among MSM may play an important role on driving the epidemic of HIV and syphilis in China in the future. This article presents results from 3 consecutive prevalence surveys of HIV and syphilis infections among MSM in Shenzhen of Guangdong China. This study aimed to understand the magnitude of HIV and syphilis infections among MSM trends in infection over time and the main corrects for infections in order to inform policy makers and develop an evidence-based syphilis control program. (excerpt)
- Published
- 2008
43. Prevalence of syphilis and HIV infections among men who have sex with men from different settings in Shenzhen, China: implications for HIV/STD surveillance
- Author
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Peng Pan, Hua Zhou, Fu-Chang Hong, Yumao Cai, Xiao-Li Liu, Xiang-Sheng Chen, and Tie-Jian Feng
- Subjects
Sexually transmitted disease ,Adult ,Male ,medicine.medical_specialty ,China ,media_common.quotation_subject ,Population ,Prevalence ,HIV Infections ,Dermatology ,Men who have sex with men ,Young Adult ,Acquired immunodeficiency syndrome (AIDS) ,immune system diseases ,Environmental health ,Epidemiology ,medicine ,Humans ,Homosexuality ,Syphilis ,Homosexuality, Male ,education ,reproductive and urinary physiology ,media_common ,education.field_of_study ,business.industry ,virus diseases ,medicine.disease ,Infectious Diseases ,Immunology ,business - Abstract
HIV/STD surveillance system data are important for developing prevention and control programmes for men who have sex with men (MSM), now a core group in Chinese HIV/STD surveillance activities. MSM were recruited from different settings in Shenzhen and were tested for HIV and syphilis. A substantial prevalence of HIV and syphilis infections was found in this population. However, risk behaviours and sociodemographic characteristics varied greatly among MSM recruited from the different settings (gay sauna, gay bar and MSM clinic), suggesting that carefully considering and selecting appropriate settings to represent the MSM population is critical for developing HIV and STD surveillance and prevention programmes.
- Published
- 2008
44. [Human immunodeficiency virus type 1 strains epidemic in Shenzhen]
- Author
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Tie-jian, Feng, Guang-lu, Zhao, Lin, Chen, Xiao-hui, Wang, and Xiang-dong, Shi
- Subjects
Adult ,Male ,China ,Molecular Epidemiology ,Adolescent ,HIV Infections ,Middle Aged ,Genes, env ,Genes, gag ,Genes, pol ,Polymerase Chain Reaction ,HIV-1 ,Humans ,Female - Abstract
To study the epidemic status of human immunodeficiency virus type 1 (HIV-1) subtypes in Shenzhen and to study their transmission source and routes.HIV-1 env and gag genes were amplified by nested PCR from uncultured peripheral blood mononuclear cells (PBMCs) obtained from 122 HIV-1 carriers confirmed in Shenzhen. The C2-V3 region (about 450 bp) of HIV-1 env and P17/ P24 region were sequenced.Among 122 samples, 6 HIV-1 strains including 3 circulating recombinant forms (CRFs) of CRF01_AE, CRF08_BC, CRF07_BC and 3 subtypes of B', B, C were found in Shenzhen, and the percentages were 45.1% (55/122) for CRF01_AE, 31.1% (38/122) for CRF08_BC, 6.6% (8/122) for CRF07_BC, 14.8% (18/122) for B' subtype, 1.6% (2/122) for B subtype, and 0.8% (1/122) for C subtype. The intragroup genetic distances were (4.455 +/- 1.478)%, (2.997 +/- 1.345)%, (4.380 +/- 2.024)%, (5.186 +/- 2.487)%, and (4.869 +/- 2.638)%, respectively. In comparison with the sequence of respective international strains 01AE. TH. 90. CM240, 97CNGX-9F, CN. 97. C54A, B. US. 83. JRFL, and RLA2, the genetic distances were (5. 228 +/- 0.823)%, (3.634 +/- 1.073)%, (4.233 +/- 1.119)%, (4.950 +/- 2.564)%, and (5.795 +/- 2.198)%, respectively. The major subtypes found in injection drug users (IDUs) were CRF07_BC, CRF08_BC, and CRF01_AE strains. CRF01_AE and B' strains were epidemic mainly in sexual workers.There are 3 HIV-1 subtypes (B', B, C) and 3 CRFs (CRF01_AE, CRF08_BC, CRF07_BC) epidemics in Shenzhen. The predominant subtypes varies among different transmission routes. While CRF01_AE is predominant among sexual workers, CRF08_BC and CRF01_AE are major subtypes among IDU population.
- Published
- 2006
45. Global human genetics of HIV-1 infection and China
- Author
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Tuo Fu Zhu, Xin Xiao, Tie jian Feng, Bo Ping Zhou, and Hui Wang
- Subjects
Genetics ,China ,Polymorphism, Genetic ,Transmission (medicine) ,Disease progression ,Human immunodeficiency virus (HIV) ,HIV Infections ,Cell Biology ,Biology ,medicine.disease_cause ,Human genetics ,medicine ,HIV-1 ,Humans ,Human genome ,Allele ,Molecular Biology - Abstract
Genetic polymorphisms in human genes can influence the risk for HIV-1 infection and disease progression, although the reported effects of these alleles have been inconsistent. This review highlights the recent discoveries on global and Chinese genetic polymorphisms and their association with HIV-1 transmission and disease progression.
- Published
- 2005
46. Risk of Congenital Syphilis (CS) Following Treatment of Maternal Syphilis: Results of a CS Control Program in China.
- Author
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Fu-Chang Hong, Xiao-Bing Wu, Fan Yang, Li-Na Lan, Yang Guan, Chun-Lai Zhang, Tie-Jian Feng, Ying-Zhou Yang, Yue-Ping Yin, Wei-Ye Yu, and Xiang-Sheng Chen
- Subjects
CONGENITAL, hereditary, & infantile syphilis ,SYPHILIS treatment ,PENICILLIN G ,DISEASE incidence ,MATERNAL health ,CONFIDENCE intervals ,DISEASE risk factors - Abstract
Background. Early screening for syphilis among pregnant women and the effective treatment of maternal syphilis is fundamental to prevent congenital syphilis (CS). Methods. We obtained data from the Shenzhen Program for Prevention of CS (SPPCS) and estimated incidence rates of CS among infants born to syphilis-seropositive women treated with different regimens or untreated for maternal syphilis. Results. A total of 4746 matched cases of syphilis-seropositive mothers and their infants were included for analyses, and 162 infants were diagnosed with CS, providing an overall incidence of 3.41% (95% confidence interval [CI], 2.91%-3.98%). Among infants born to syphilis-seropositive women who had syphilis and were adequately treated before pregnancy, the incidence was 0.22% (95% CI, .05%-.66%). There were 159 cases of CS occurring in 3519 infants born to women who were syphilis-seropositive during their pregnancies, for an incidence of 4.52% (95% CI, 3.84%-5.28%). The incidence of CS was 1.82%-11.90% lower among infants born to the women treated with early benzathine penicillin G (BPG) compared with those treated with late BPG (adjusted odds ratio [aOR], 8.06 [95% CI, 2.93-22.21]; P < .001), other antibiotics (aOR, 7.71 [95% CI, .86-69.28]; P = .068), or those untreated (aOR, 68.28 [95% CI, 29.64-157.28]; P < .001). The incidence rates were 0.22% (95% CI, .06%-.80%) and 0.59% (95% CI, .35%-1.02%) in infants born to women treated with 2 courses and 1 course of BPG, respectively, corresponding to a risk difference of 0.37% (aOR, 1.74; 95% CI, .37-8.26). Conclusions. Treatment of syphilis-seropositive pregnant women with 1 course of intramuscular BPG before 28 gestational weeks is critical for prevention of CS. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
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47. A preliminary validation of the Brief COPE instrument for assessing coping strategies among people living with HIV in China.
- Author
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Xiao-you Su, Joseph TF Lau, Winnie WS Mak, KC Choi, Tie-jian Feng, Xi Chen, Chu-liang Liu, Jun Liu, De Liu, Lin Chen, Jun-min Song, Yan Zhang, Guang-lu Zhao, Zhang-ping Zhu, and Jin-quan Cheng
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HIV-positive persons ,CONFIRMATORY factor analysis ,EXPLORATORY factor analysis - Abstract
Background: The Brief COPE instrument has been utilized to conduct research on various populations, including people living with HIV (PLWH). However, the questionnaire constructs when applied to PLWH have not been subjected to thorough factor validation. Methods: A total of 258 PLWH were recruited from two provinces of China. They answered questions involving the scales of three instruments: the Brief COPE, the Perceived Social Support Scale, and the Perceived Discrimination Scale for PLWH. Confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) were conducted. Results: The CFA found a poor goodness of fit to the data. The subsequent EFA identified six preliminary factors, forming subscales with Cronbach's alphas, which ranged from 0.61 to 0.80. Significant correlation coefficients between the subscales and measures of perceived social support and perceived discrimination were reported, giving preliminary support to the validity of the new empirical factor structure. Conclusion: This study showed that the original factor structure of the Brief COPE instrument, when applied to PLWH in China, did not fit the data. Thus, the Brief COPE should be applied to various populations and cultures with caution. The new factor structure established by the EFA is only preliminary and requires further validation. [ABSTRACT FROM AUTHOR]
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- 2015
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48. Risk Factors for Congenital Syphilis and Adverse Pregnancy Outcomes in Offspring of Women With Syphilis in Shenzhen, China: A Prospective Nested Case-Control Study.
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Jia-Bi Qin, Tie-Jian Feng, Tu-Bao Yang, Fu-Chang Hong, Li-Na Lan, Chun-Lai Zhang, Fan Yang, Keita Mamady, and Willa Dong
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Background: Despite existence of a highly effective intervention, maternal syphilis still causes substantial perinatal morbidity and mortality, even in China, where antenatal health services are strong. This study sought to address personal, programmatic, and other risk factors for congenital syphilis (CS) and adverse pregnancy outcomes (APOs) among pregnant women in Shenzhen, China. Methods: Pregnant women attending antenatal services were offered serologic tests, and those diagnosed as having syphilis were recruited from April 2007 to October 2012. In a nested case-control study for the pregnancy outcomes of syphilis-infected women, we assessed risk factors comparing infants born with CS (group II) and with any APOs (group III) to infants without CS or APOs (group I). Results: During the 66-month study period, we screened 279,334 pregnant women and identified 838 (0.3%; 95% confidence interval, 0.28%-0.32%) women infected with syphilis. Among infants bom to syphilitic mothers, 8.2% (34/417) were diagnosed as having CS and 24.7% (103/417) were diagnosed as having APOs. Compared with group I, maternal baseline titers of nontreponemal antibodies (adjusted odds ratio [aOR], 2.13), stage of syphilis (aOR, 21.56), length of time between the end of the first treatment to childbirth (aOR, 11.93), gestational week at treatment (aOR, 2.63), and fathers' cocaine use (aOR, 15.44) and syphilis infection status (aORposjtive vs. negative, 5.84; aORunknown vs negative, 5.55) were positively associated with CS, but prenatal care (aOR, 0.11) and complete treatment (aOR, 0.20) were negatively associated with CS. Maternal age (aOR, 1.43), marriage (aOR, 2.41), history of cocaine use (aOR, 3.79) and ectopic pregnancy (aOR, 5.91), baseline titers of nontreponemal antibodies (aOR, 1.30), stage of syphilis (aOR, 8.89), length of time between the end of the first treatment to childbirth (aOR, 2.52), gestational week at treatment (aOR, 1.78), and fathers' syphilis infection status (aORunknown vs. negative. 2.02) were also positively associated with APOs, but maternal history of syphilis (aOR. 0.44), prenatal care (aOR, 0.29), and complete treatment (aOR, 0.25) were negatively associated with APOs, Conclusions: Syphilis was an important cause of pregnancy loss and infant disability, particularly among women who did not receive prenatal care or had late or inadequate treatment. These study results can inform antenatal programs on the importance of early syphilis testing and prompt and appropriate tteatment. Some strategies targeted at other risk factors areas may be helpful. [ABSTRACT FROM AUTHOR]
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- 2014
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49. Molecular epidemiology of genital Chlamydia trachomatis infection in Shenzhen, China.
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Juan-Juan Zhang, Guang-Lu Zhao, Feng Wang, Fu-Chang Hong, Zhen-Zhou Luo, Li-Na Lan, Chun-Lai Zhang, Yi Peng, Xiao-Li Liu, Tie-Jian Feng, and Xiang-Sheng Chen
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MOLECULAR epidemiology ,CHLAMYDIA trachomatis ,SEXUALLY transmitted disease diagnosis ,EPIDEMIOLOGY of sexually transmitted diseases ,SOCIOECONOMIC factors - Abstract
Objective To investigate molecular epidemiology of Chlamydia trachomatis infection among patients recruited from different clinic settings in Shenzhen, China. Methods A total of 2534 patients from the sexually transmitted disease (STD) clinics, obstetrics and gynaecology (OBGYN) clinics and genitourinary medicine (GUM) clinics in 34 hospitals participated in the study. The C trachomatis infection was determined using COBAS Amplicor system. DNA extracted in C trachomatis-positive samples was amplified using a nested PCR based on ompA gene and then genotyped using a microsphere suspension array. Results The overall prevalence of genital C trachomatis infection was 17.7%. The prevalence in patients at STD or GUM clinics was significantly higher than that in patients at OBGYN clinics. Being male (adjusted OR (AOR) 2.5, 95% CI 1.8 to 3.4), having no consistent use of a condom with casual partners in the past 3 months (AOR 1.7, 95% CI 1.1 to 2.8) and having any STD symptoms (AOR 3.3, 95% CI 2.0 to 5.4) were independently associated with C trachomatis infection. Eight genotypes were identified. The most prevalent genotypes were F (22.3%), E (22.0%) and D/Da (12.7%). Other genotypes were G/Ga (8.0%), J (7.3%), K (2.7%), H (2.7%) and I/Ia (0.4%). Eighty-two samples (18.3%) were infected with multiple genotypes. Genotype D/Da among patients from GUM clinics was more common than those from STD or OBGYN clinics. Infections with genotypes G and F were statistically associated with abnormal vaginal discharge (p=0.001) and being married (p=0.014), respectively. Infection with multiple genotypes was more common among patients with a higher income (p=0.011). Conclusion A substantial prevalence of genital C trachomatis infection in Shenzhen suggests the importance of detection and treatment of the infection in high-risk groups. [ABSTRACT FROM AUTHOR]
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- 2012
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50. Population Survey of CCR5 δ32, CCR5 m303, CCR2b 64I, and SDF1 3'A Allele Frequencies in Indigenous Chinese Healthy Individuals, and in HIV-1-Infected and HIV-1-Uninfected Individuals in HIV-1 Risk Groups.
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Fu-Sheng Wang, Wei-Guo Hong, Yunzhen Cao, Ming-Xu Liu, Lei Jin, Liang-Ping Hu, Zhe Wang, Tie-jian Feng, Jing Hou, Bing Zhang, Ming Shi, Dong-Ping Xu, Zhou-Yun Lei, Bo Wang, Zheng-Dong Liu, Jun-Jie Ye, Lin Peng, Ya Qui, and Winkler, Cheryl
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- 2003
- Full Text
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