Search

Your search keyword '"Tigyi, Gabor"' showing total 640 results
Start Over Author "Tigyi, Gabor"
640 results on '"Tigyi, Gabor"'

3. Optical Control of Lysophosphatidic Acid Signaling

Author

Morstein, Johannes, Dacheux, Mélanie A, Norman, Derek D, Shemet, Andrej, Donthamsetti, Prashant C, Citir, Mevlut, Frank, James A, Schultz, Carsten, Isacoff, Ehud Y, Parrill, Abby L, Tigyi, Gabor J, and Trauner, Dirk

Subjects
Humans, Lysophospholipids, Photochemical Processes, Receptors, Lysophosphatidic Acid, Signal Transduction, Chemical Sciences, General Chemistry
Abstract

Lysophosphatidic acid (LPA) is a phospholipid that acts as an extracellular signaling molecule and activates the family of lysophosphatidic acid receptors (LPA1-6). These G protein-coupled receptors (GPCRs) are broadly expressed and are particularly important in development as well as in the nervous, cardiovascular, reproductive, gastrointestinal, and pulmonary systems. Here, we report on a photoswitchable analogue of LPA, termed AzoLPA, which contains an azobenzene photoswitch embedded in the acyl chain. AzoLPA enables optical control of LPA receptor activation, shown through its ability to rapidly control LPA-evoked increases in intracellular Ca2+ levels. AzoLPA shows greater activation of LPA receptors in its light-induced cis-form than its dark-adapted (or 460 nm light-induced) trans-form. AzoLPA enabled the optical control of neurite retraction through its activation of the LPA2 receptor.

Published
2020

5. Optical control of sphingosine-1-phosphate formation and function.

Author

Morstein, Johannes, Hill, Rose Z, Novak, Alexander JE, Feng, Suihan, Norman, Derek D, Donthamsetti, Prashant C, Frank, James A, Harayama, Takeshi, Williams, Benjamin M, Parrill, Abby L, Tigyi, Gabor J, Riezman, Howard, Isacoff, Ehud Y, Bautista, Diana M, and Trauner, Dirk

Subjects
Animals, Mice, Sphingosine, Lysophospholipids, Molecular Structure, Models, Molecular, Photochemical Processes, Optical Imaging, Biochemistry & Molecular Biology, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology
Abstract

Sphingosine-1-phosphate (S1P) plays important roles as a signaling lipid in a variety of physiological and pathophysiological processes. S1P signals via a family of G-protein-coupled receptors (GPCRs) (S1P1-5) and intracellular targets. Here, we report on photoswitchable analogs of S1P and its precursor sphingosine, respectively termed PhotoS1P and PhotoSph. PhotoS1P enables optical control of S1P1-3, shown through electrophysiology and Ca2+ mobilization assays. We evaluated PhotoS1P in vivo, where it reversibly controlled S1P3-dependent pain hypersensitivity in mice. The hypersensitivity induced by PhotoS1P is comparable to that induced by S1P. PhotoS1P is uniquely suited for the study of S1P biology in cultured cells and in vivo because it exhibits prolonged metabolic stability compared to the rapidly metabolized S1P. Using lipid mass spectrometry analysis, we constructed a metabolic map of PhotoS1P and PhotoSph. The formation of these photoswitchable lipids was found to be light dependent, providing a novel approach to optically probe sphingolipid biology.

Published
2019

6. Functional modulation of lysophosphatidic acid type 2 G‐protein coupled receptor facilitates alveolar bone formation

Author

Kim, Tae‐Young, primary, Kim, Anna, additional, Aryal, Yam Prasad, additional, Sung, Shijin, additional, Pokharel, Elina, additional, Neupane, Sanjiv, additional, Choi, So‐Young, additional, Ha, Jung‐Hong, additional, Jung, Jae‐Kwang, additional, Yamamoto, Hitoshi, additional, An, Chang‐Hyeon, additional, Suh, Jo‐Young, additional, Sohn, Wern‐Joo, additional, Lee, Youngkyun, additional, Jang, Il‐Ho, additional, Norman, Derek D., additional, Tigyi, Gabor J., additional, An, Seo‐Young, additional, and Kim, Jae‐Young, additional

Published
2023
Full Text
View/download PDF

8. Paneth cell dysfunction in radiation injury and radio-mitigation by human α-defensin 5

Author

Shukla, Pradeep K., primary, Rao, Roshan G., additional, Meena, Avtar S., additional, Giorgianni, Francesco, additional, Lee, Sue Chin, additional, Raju, Preeti, additional, Shashikanth, Nitesh, additional, Shekhar, Chandra, additional, Beranova, Sarka, additional, Balazs, Louisa, additional, Tigyi, Gabor, additional, Gosain, Ankush, additional, and Rao, RadhaKrishna, additional

Published
2023
Full Text
View/download PDF

9. Functional modulation of lysophosphatidic acid type 2 G‐protein coupled receptor facilitates alveolar bone formation.

Author

Kim, Tae‐Young, Kim, Anna, Aryal, Yam Prasad, Sung, Shijin, Pokharel, Elina, Neupane, Sanjiv, Choi, So‐Young, Ha, Jung‐Hong, Jung, Jae‐Kwang, Yamamoto, Hitoshi, An, Chang‐Hyeon, Suh, Jo‐Young, Sohn, Wern‐Joo, Lee, Youngkyun, Jang, Il‐Ho, Norman, Derek D., Tigyi, Gabor J., An, Seo‐Young, and Kim, Jae‐Young

Subjects
BONE growth, ALVEOLAR process, LYSOPHOSPHOLIPIDS, BONE regeneration, CELL culture, TOOTH socket, G protein coupled receptors, CELL physiology, TRANSFORMING growth factors-beta
Abstract

Lipid biosynthesis is recently studied its functions in a range of cellular physiology including differentiation and regeneration. However, it still remains to be elucidated in its precise function. To reveal this, we evaluated the roles of lysophosphatidic acid (LPA) signaling in alveolar bone formation using the LPA type 2 receptor (LPAR2) antagonist AMG‐35 (Amgen Compound 35) using tooth loss without periodontal disease model which would be caused by trauma and usually requires a dental implant to restore masticatory function. In this study, in vitro cell culture experiments in osteoblasts and periodontal ligament fibroblasts revealed cell type‐specific responses, with AMG‐35 modulating osteogenic differentiation in osteoblasts in vitro. To confirm the in vivo results, we employed a mouse model of tooth loss without periodontal disease. Five to 10 days after tooth extraction, AMG‐35 facilitated bone formation in the tooth root socket as measured by immunohistochemistry for differentiation markers KI67, Osteocalcin, Periostin, RUNX2, transforming growth factor beta 1 (TGF‐β1) and SMAD2/3. The increased expression and the localization of these proteins suggest that AMG‐35 elicits osteoblast differentiation through TGF‐β1 and SMAD2/3 signaling. These results indicate that LPAR2/TGF‐β1/SMAD2/3 represents a new signaling pathway in alveolar bone formation and that local application of AMG‐35 in traumatic tooth loss can be used to facilitate bone regeneration and healing for further clinical treatment. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

12. Supplementary Figure 3 from Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

Author

Lee, Sue-Chin, primary, Fujiwara, Yuko, primary, Liu, Jianxiong, primary, Yue, Junming, primary, Shimizu, Yoshibumi, primary, Norman, Derek D., primary, Wang, Yaohong, primary, Tsukahara, Ryoko, primary, Szabo, Erzsebet, primary, Patil, Renukadevi, primary, Banerjee, Souvik, primary, Miller, Duane D., primary, Balazs, Louisa, primary, Ghosh, Manik C., primary, Waters, Christopher M., primary, Oravecz, Tamas, primary, and Tigyi, Gabor J., primary

Published
2023
Full Text
View/download PDF

13. Supplementary Figure 5 from Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

Author

Lee, Sue-Chin, primary, Fujiwara, Yuko, primary, Liu, Jianxiong, primary, Yue, Junming, primary, Shimizu, Yoshibumi, primary, Norman, Derek D., primary, Wang, Yaohong, primary, Tsukahara, Ryoko, primary, Szabo, Erzsebet, primary, Patil, Renukadevi, primary, Banerjee, Souvik, primary, Miller, Duane D., primary, Balazs, Louisa, primary, Ghosh, Manik C., primary, Waters, Christopher M., primary, Oravecz, Tamas, primary, and Tigyi, Gabor J., primary

Published
2023
Full Text
View/download PDF

15. Supplementary Figure 4 from Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

Author

Lee, Sue-Chin, primary, Fujiwara, Yuko, primary, Liu, Jianxiong, primary, Yue, Junming, primary, Shimizu, Yoshibumi, primary, Norman, Derek D., primary, Wang, Yaohong, primary, Tsukahara, Ryoko, primary, Szabo, Erzsebet, primary, Patil, Renukadevi, primary, Banerjee, Souvik, primary, Miller, Duane D., primary, Balazs, Louisa, primary, Ghosh, Manik C., primary, Waters, Christopher M., primary, Oravecz, Tamas, primary, and Tigyi, Gabor J., primary

Published
2023
Full Text
View/download PDF

16. Supplementary Figure 1 from Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

Author

Lee, Sue-Chin, primary, Fujiwara, Yuko, primary, Liu, Jianxiong, primary, Yue, Junming, primary, Shimizu, Yoshibumi, primary, Norman, Derek D., primary, Wang, Yaohong, primary, Tsukahara, Ryoko, primary, Szabo, Erzsebet, primary, Patil, Renukadevi, primary, Banerjee, Souvik, primary, Miller, Duane D., primary, Balazs, Louisa, primary, Ghosh, Manik C., primary, Waters, Christopher M., primary, Oravecz, Tamas, primary, and Tigyi, Gabor J., primary

Published
2023
Full Text
View/download PDF

17. Data from Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

Author

Lee, Sue-Chin, primary, Fujiwara, Yuko, primary, Liu, Jianxiong, primary, Yue, Junming, primary, Shimizu, Yoshibumi, primary, Norman, Derek D., primary, Wang, Yaohong, primary, Tsukahara, Ryoko, primary, Szabo, Erzsebet, primary, Patil, Renukadevi, primary, Banerjee, Souvik, primary, Miller, Duane D., primary, Balazs, Louisa, primary, Ghosh, Manik C., primary, Waters, Christopher M., primary, Oravecz, Tamas, primary, and Tigyi, Gabor J., primary

Published
2023
Full Text
View/download PDF

18. Supplementary Figure 2 from Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

Author

Lee, Sue-Chin, primary, Fujiwara, Yuko, primary, Liu, Jianxiong, primary, Yue, Junming, primary, Shimizu, Yoshibumi, primary, Norman, Derek D., primary, Wang, Yaohong, primary, Tsukahara, Ryoko, primary, Szabo, Erzsebet, primary, Patil, Renukadevi, primary, Banerjee, Souvik, primary, Miller, Duane D., primary, Balazs, Louisa, primary, Ghosh, Manik C., primary, Waters, Christopher M., primary, Oravecz, Tamas, primary, and Tigyi, Gabor J., primary

Published
2023
Full Text
View/download PDF

19. Supplementary Table 1 from Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

Author

Lee, Sue-Chin, primary, Fujiwara, Yuko, primary, Liu, Jianxiong, primary, Yue, Junming, primary, Shimizu, Yoshibumi, primary, Norman, Derek D., primary, Wang, Yaohong, primary, Tsukahara, Ryoko, primary, Szabo, Erzsebet, primary, Patil, Renukadevi, primary, Banerjee, Souvik, primary, Miller, Duane D., primary, Balazs, Louisa, primary, Ghosh, Manik C., primary, Waters, Christopher M., primary, Oravecz, Tamas, primary, and Tigyi, Gabor J., primary

Published
2023
Full Text
View/download PDF

21. Supplemental Figure Legends from Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

Author

Lee, Sue-Chin, primary, Fujiwara, Yuko, primary, Liu, Jianxiong, primary, Yue, Junming, primary, Shimizu, Yoshibumi, primary, Norman, Derek D., primary, Wang, Yaohong, primary, Tsukahara, Ryoko, primary, Szabo, Erzsebet, primary, Patil, Renukadevi, primary, Banerjee, Souvik, primary, Miller, Duane D., primary, Balazs, Louisa, primary, Ghosh, Manik C., primary, Waters, Christopher M., primary, Oravecz, Tamas, primary, and Tigyi, Gabor J., primary

Published
2023
Full Text
View/download PDF

23. Supplementary Methods, Figures 1-3, Table 1 from Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

Author

Zhang, Honglu, primary, Xu, Xiaoyu, primary, Gajewiak, Joanna, primary, Tsukahara, Ryoko, primary, Fujiwara, Yuko, primary, Liu, Jianxiong, primary, Fells, James I., primary, Perygin, Donna, primary, Parrill, Abby L., primary, Tigyi, Gabor, primary, and Prestwich, Glenn D., primary

Published
2023
Full Text
View/download PDF

24. Data from Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

Author

Zhang, Honglu, primary, Xu, Xiaoyu, primary, Gajewiak, Joanna, primary, Tsukahara, Ryoko, primary, Fujiwara, Yuko, primary, Liu, Jianxiong, primary, Fells, James I., primary, Perygin, Donna, primary, Parrill, Abby L., primary, Tigyi, Gabor, primary, and Prestwich, Glenn D., primary

Published
2023
Full Text
View/download PDF

28. Combined Mitigation of the Gastrointestinal and Hematopoietic Acute Radiation Syndromes by an LPA2 Receptor-Specific Nonlipid Agonist

Author

Patil, Renukadevi, Szabó, Erzsébet, Fells, James I., Balogh, Andrea, Lim, Keng G., Fujiwara, Yuko, Norman, Derek D., Lee, Sue-Chin, Balazs, Louisa, Thomas, Fridtjof, Patil, Shivaputra, Emmons-Thompson, Karin, Boler, Alyssa, Strobos, Jur, McCool, Shannon W., Yates, C. Ryan, Stabenow, Jennifer, Byrne, Gerrald I., Miller, Duane D., and Tigyi, Gábor J.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results