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Abstract Background Systematic reviews and meta-analyses reveal the importance of an accepting attitude towards cancer for mental health and functional coping. The aim of this study was to examine the psychometric properties of the German translation of the Peace, Equanimity, and Acceptance in the Cancer Experience (PEACE) questionnaire (Mack et al., 2008) and to investigate its associations with mental health, health-related quality of life (HRQoL) and related constructs. Methods The German version of the PEACE (PEACE-G) was created and validated with cancer patients in a cross-sectional two center questionnaire study. Construct validity was tested with confirmational factor analyses (CFA); Cronbach’s alpha was used to determine internal consistency of items. We further examined associations with depression (PHQ-8), anxiety (GAD-7), distress (NCCN distress thermometer), HRQoL (SF-12), psychological flexibility (AAQ-II), resilience (RS-11) and acceptance scales, to evaluate concurrent and divergent validity. Results N = 213 cancer patients with different tumor entities participated in this study. Results of the CFA replicated the two-factor solution of the original PEACE (peaceful acceptance and struggle with illness) with satisfactory psychometric properties. Peaceful acceptance showed negative associations with depression, anxiety, distress, psychological inflexibility, and positive associations with HRQoL, acceptance, resilience, and mindfulness. Results of sensitivity analyses indicate a third factor (injustice/anger). Conclusions The results demonstrate the validity and reliability of PEACE-G in cancer patients and point to the essential role of acceptance- and mindfulness-based interventions in psycho-oncology. Further studies are needed to investigate the different facets of struggle with the cancer illness.

Efficient quantum memories will be an essential building block of large-scale networked quantum systems and provide a link between flying photonic qubits and atomic or quasi-atomic local quantum processors. Memory efficiencies above 50% are required to be operating above the quantum no-cloning limit. High efficiency operation necessitates tailored photon source and memory pairs with matched bandwidths. In this paper, we explore the combination of an ultralow spectral bandwidth source of single photons from cavity-enhanced spontaneous parametric down-conversion with a hot gas-ensemble atomic memory. Our rubidium vapor gradient echo memory achieves 84% ± 3% recall efficiency of single photons: a record for single photon storage in a warm vapor platform that avoids bulky and complex systems, such as high vacuum and low temperature cryogenics.

Organic photocatalysts frequently possess dual singlet and triplet photoreactivity and a thorough photochemical characterization is essential for efficient light-driven applications. In this article, the mode of action of a polyazahelicene catalyst (Aza-H) was investigated using laser flash photolysis (LFP). The study revealed that the chromophore can function as a singlet-state photoredox catalyst in the sulfonylation/arylation of styrenes and as a triplet sensitizer in energy transfer catalysis. The singlet lifetime is sufficiently long to exploit the exceptional excited state reduction potential for the activation of 4-cyanopyridine. Photoinduced electron transfer generating the radical cation was directly observed confirming the previously proposed mechanism of a three-component reaction. Several steps of the photoredox cycle were investigated separately, providing deep insights into the complex mechanism. The triplet-excited Aza-H, which was studied with quantitative LFP, is formed with a quantum yield of 0.34. The pronounced triplet formation was exploited for the isomerization reaction of (E)-stilbene to the Z-isomer and the cyclization of cinnamyl chloride. Catalyst degradation mainly occurs through the long-lived Aza-H triplet (28 µs), but the photostability is greatly increased when the triplet efficiently reacts in a catalytic cycle such that turnover numbers exceeding 4400 are achievable with this organocatalyst.

Abstract An increasing number of studies in botanical gardens are investigating species' responses to climate change. However, the influence of local environmental or habitat conditions such as soil nutrient status or microclimate on phenology and the link between morpho‐physiological functional traits and phenological stages are poorly understood, making it difficult to extrapolate patterns from botanical gardens to natural environments. Therefore, we selected herbaceous species growing in two semi‐natural habitats, namely, semi‐dry grasslands (SDGs) and mesophilic grasslands (MGs) and the botanical garden of Jena (Germany) to investigate the influence of habitat conditions on interspecific and intraspecific patterns in phenology, functional traits and their associations. For 16 species, we monitored leaf and flowering phenology weekly for 133 populations from the three habitats, measured morpho‐physiological traits (i.e., whole plant, leaf and reproductive traits), as well as habitat conditions and compared the measurements across habitats. Multivariate analyses revealed that morpho‐physiological traits conspicuously showed stronger differences between habitats compared to phenological traits. Populations on MG showed temporal niche segregation, whereas populations on SDG showed flowering synchrony. Boosted Regression Trees showed that morpho‐physiological traits, especially reproductive traits, strongly influenced phenological traits and that the trait‐phenology relationships were highly habitat‐specific. We conclude that species phenology is broadly similar between botanical gardens and local habitats. However, phenological responses to the environment may be constrained by a certain suite of correlated traits due to ecological plant strategies that vary across habitats. The effect of habitat conditions on morpho‐physiological functional traits and phenology‐trait relationships is important and should not be neglected at local scales, implying consequences at larger scales.

Abstract Low elevation equatorial and tropical coastal regions are highly vulnerable to sea level rise. Here we provide probability perspectives of future sea level for Singapore using regional geological reconstructions and instrumental records since the last glacial maximum ~21.5 thousand years ago. We quantify magnitudes and rates of sea-level change showing deglacial sea level rose from ~121 m below present level and increased at averaged rates up to ~15 mm/yr, which reduced the paleogeographic landscape by ~2.3 million km2. Projections under a moderate emissions scenario show sea level rising 0.95 m at a rate of 7.3 mm/yr by 2150 which has only been exceeded (at least 99% probability) during rapid ice mass loss events ~14.5 and ~9 thousand years ago. Projections under a high emissions scenario incorporating low confidence ice-sheet processes, however, have no precedent during the last deglaciation.

Off the Northwestern Iberian Peninsula, the vigorous bottom-current regime interacts with a complex seafloor topography inside the Galicia Interior Basin (GIB), which was tectonically shaped during the opening of the North Atlantic Ocean basin in Cretaceous times. The evolving North Atlantic Ocean circulation determined the depositional pattern of the basin fill over time, which can, in turn, be utilized as palaeoceanographic archive. This study reconstructs the evolution of the GIB sedimentary system since the mid-Eocene, namely, resulting from interplay between down- and along-slope sediment-transport processes, using high-resolution multichannel seismic data. Six major depositional stages are identified and connected to the evolution of the North Atlantic Ocean circulation. 1) Levelling of topography shows that the influence of contourparallel bottom currents on the depositional pattern steadily intensified since the mid-Eocene; 2) The strengthening of Northern Component Water (NCW), associated with the opening of the Faeroe-Shetland Basin in the late Eocene, is documented along the southwestern European continental margin for the first time by the onset of a plastered contourite drift; 3) A shift in the depocenters provide evidence that the closure of the Tethys-Indian Seaway led to Tethys Outflow Water into the Atlantic Ocean at intermediate ocean depths in the Miocene; 4) Until the mid-Miocene, the tectonic stress regime initially associated with the Pyrenean Orogeny and the following Betic Orogeny led to both sets of small-scale faulting systems as well as submarine mass wasting indicated by slope scarps and mass-transport deposits; 5) The onset of modern-style Mediterranean Outflow Water (MOW) after the Messinian Salinity Crisis (5.3 Ma) caused a distinct change in the depositional dynamics from combined along- and down-slope transport processes towards predominantly contouritic deposition, which is evident from the construction of several separated mounded contouritic drifts that formed during Pliocene and early Pleistocene times; and 6) The contourite drift growth continued during the middle and late Pleistocene, but under a gaining influence of down-slope processes.

Abstract At most latitudes, the seasonal cycle of zonal‐mean surface air temperature is notably asymmetric: the length of the warming season is not equal to the length of the cooling season. The asymmetry varies spatially, with the cooling season being ∼40 days shorter than the warming season in the subtropics and the warming season being ∼100 days shorter than the cooling season at the poles. Furthermore, the asymmetry differs between the Northern Hemisphere and the Southern Hemisphere. Here, we show that these observed features are broadly captured in a simple model for the evolution of temperature forced by realistic insolation. The model suggests that Earth's orbital eccentricity largely determines the hemispheric contrast, and obliquity broadly dictates the meridional structure. Clouds, atmospheric heat flux convergence, and time‐invariant effective surface heat capacity have minimal impacts on seasonal asymmetry. This simple, first‐order picture has been absent from previous discussions of the surface temperature seasonal cycle.

The Antarctic Ice Sheet loses mass via its ice shelves predominantly through two processes: basal melting and iceberg calving. Iceberg calving is episodic and infrequent, and not well parameterized in ice-sheet models. Here, we investigate the impact of hydrostatic forces on calving. We develop two-dimensional elastic and viscous numerical frameworks to model the ‘footloose’ calving mechanism. This mechanism is triggered by submerged ice protrusions at the ice front, which induce unbalanced buoyancy forces that can lead to fracturing. We compare the results to identify the different roles that viscous and elastic deformations play in setting the rate and magnitude of calving events. Our results show that, although the bending stresses in both frameworks share some characteristics, their differences have important implications for modeling the calving process. In particular, the elastic model predicts that maximum stresses arise farther from the ice front than in the viscous model, leading to larger calving events. We also find that the elastic model would likely lead to more frequent events than the viscous one. Our work provides a theoretical framework for the development of a better understanding of the physical processes that govern glacier and ice-shelf calving cycles.

Abstract Background General Practitioners (GPs) are increasingly affected by stress-related complaints and burnout. Although many studies have addressed this issue, little is known about the stress burden and burnout rates of postgraduate trainees specialising in General Practice (GP). This cross-sectional study was performed to explore the prevalence and risk of depression, stress and burnout in a large cohort of GP trainees. Methods All GP trainees enrolled in the postgraduate training programme KWBW Verbundweiterbildung plus © in southwest Germany were invited to participate. A paper-based survey for the purpose of psychosocial screening was used: Prevalence of depression, perceived stress and burnout were measured with the depression module of the Patient Health Questionnaire (PHQ-9), Perceived Stress Questionnaire (PSQ-20) and Maslach Burnout Inventory (MBI). Additionally, linear regression models were used to analyse the association between sociodemographic characteristics and mental health scales. Results N = 211 GP trainees participated in this study (response rate 95%). 75.3% (n = 159) of the participants were female and median age was 34 (IQR 32; 39). GP trainees had a mean PHQ-9 sum score of 5.4 (SD 3.4). Almost 11% (n = 23) reported symptoms of a moderate or moderately severe depression. PSQ-20 revealed moderate level of distress, whereas 20.8% (n = 42) showed a high level of perceived stress with a sum-score higher than .59. GP trainees showed moderate rates of burnout and only 2.5% (n = 5) scored high in all three dimensions of the MBI score. GP trainees showed increased levels of depression, perceived stress and burnout when compared with age-matched general population. Being a woman led to a higher PHQ-9 sum score (p

Abstract Background Traumatic brain injury (TBI) is a major cause of death and disability. T cells were shown to infiltrate the brain during the first days after injury and to exacerbate tissue damage. The objective of this study was to investigate the hitherto unresolved role of immunosuppressive, regulatory T cells (Tregs) in experimental TBI. Methods “Depletion of regulatory T cell” (DEREG) and wild type (WT) C57Bl/6 mice, treated with diphtheria toxin (DTx) to deplete Tregs or to serve as control, were subjected to the controlled cortical impact (CCI) model of TBI. Neurological and motor deficits were examined until 5 days post-injury (dpi). At the 5 dpi endpoint, (immuno-) histological, protein, and gene expression analyses were carried out to evaluate the consequences of Tregs depletion. Comparison of parametric or non-parametric data between two groups was done using Student’s t test or the Mann-Whitney U test. For multiple comparisons, p values were calculated by one-way or two-way ANOVA followed by specific post hoc tests. Results The overall neurological outcome at 5 dpi was not different between DEREG and WT mice but more severe motor deficits occurred transiently at 1 dpi in DEREG mice. DEREG and WT mice did not differ in the extent of brain damage, blood-brain barrier (BBB) disruption, or neuronal excitotoxicity, as examined by lesion volumetry, immunoglobulin G (IgG) extravasation, or calpain-generated αII-spectrin breakdown products (SBDPs), respectively. In contrast, increased protein levels of glial fibrillary acidic protein (GFAP) and GFAP+ astrocytes in the ipsilesional brain tissue indicated exaggerated reactive astrogliosis in DEREG mice. T cell counts following anti-CD3 immunohistochemistry and gene expression analyses of Cd247 (CD3 subunit zeta) and Cd8a (CD8a) further indicated an increased number of T cells infiltrating the brain injury sites of DEREG mice compared to WT. These changes coincided with increased gene expression of pro-inflammatory interferon-γ (Ifng) in DEREG mice compared to WT in the injured brain. Conclusions The results show that the depletion of Tregs attenuates T cell brain infiltration, reactive astrogliosis, interferon-γ gene expression, and transiently motor deficits in murine acute traumatic brain injury.

We report 100% duty cycle generation of sub-MHz single photon pairs at the rubidium D1 line using cavity-enhanced spontaneous parametric downconversion. The temporal intensity cross correlation function exhibits a bandwidth of 666±16 kHz for the single photons, an order of magnitude below the natural linewidth of the target transition. A half-wave plate inside our cavity helps to achieve triple resonance between pump, signal, and idler photon, reducing the bandwidth and simplifying the locking scheme. Additionally, stabilisation of the cavity to the pump frequency enables the 100% duty cycle. The quantum nature of the source is confirmed by the idler-triggered second-order autocorrelation function at τ=0 to be gs,s(2)(0)= 0.016±0.002 for a heralding rate of 5 kHz. The generated photons are well-suited for storage in quantum memory schemes with sub-natural linewidths, such as gradient echo memories.

Following publication of the original article [1], the authors opted to correct the following mistakes. According to the title and our results, the conclusions in the abstract and at the end of the discussion the term “attenuates” must be corrected to read as “increases”.

This study explores the relationship between the governance of architecturally embedded applications and their longevity in organizational use. Using a contingency-fit logic, it posits that alignment between application governance (distribution of decision rights) and architectural contingencies contributes to sustained durations of organizational use. Architectural contingencies include internal application modularity, application inter-connectedness, and governance of surrounding application clusters. Evidence for the governance-architecture fit hypothesis is derived from analyzing temporally ordered data about applications (n = 225, n = 498, n = 193) from organizations in the media, banking, and utilities sectors over five years. Using a two-step approach with ordinal regression, along with Cox proportional hazards and logistic regression models, our findings indicate that a fit between observed governance and the governance induced by architectural contingencies reduces the likelihood of application decommissioning. The study advances the fields of information systems (IS) governance and architecture by offering a micro-level perspective on the longevity of organizational IS use while also shedding light on the importance of governance choices aligned with unique architectural application properties. [ABSTRACT FROM AUTHOR]