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24 results on '"Timmer, Margriet R."'

2. Sa1135 – Genomic Biomarkers for Cancer Risk in Barrett's Esophagus: An Update on the Longitudinal Dutch Barrett's Esophagus Cohort

Author

Hoefnagel, Sanne, primary, Westra, Wytske H., additional, Timmer, Margriet R., additional, Martinez, Pierre, additional, Klaver, Esther, additional, Calpe, Silvia, additional, del Carmen Sancho-Serra, Maria, additional, Straub, Danielle, additional, Baker, Ann-Marie, additional, Rosmolen, Wilda, additional, Meijer, Sybren L., additional, Kate, Fiebo Ten, additional, Dijkgraaf, Marcel, additional, Mallant-Hent, Rosalie, additional, Naber, Anton H., additional, van Oijen, Arnoud, additional, Baak, Lubbertus C., additional, Scholten, Pieter, additional, Böhmer, Clarisse, additional, Maley, Carlo, additional, Graham, Trevor A., additional, Bergman, Jacques, additional, and Krishnadath, Kausilia K., additional

Published
2019
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3. Aberrant TP53 detected by combining immunohistochemistry and DNA-FISH improves Barrett's esophagus progression prediction : A prospective follow-up study

Author

Davelaar, Akueni L., Calpe, Silvia, Lau, Liana, Timmer, Margriet R., Visser, Mike, ten Kate, Fiebo J., Parikh, Kaushal B., Meijer, Sybren L., Bergman, Jacques J., Fockens, Paul, Krishnadath, Kausilia K., Other departments, Gastroenterology and Hepatology, Pathology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and CCA -Cancer Center Amsterdam

Subjects
Medicine(all), Cancer Research, Evaluation Studies, Genetics, Journal Article, neoplasms
Abstract

Barrett's esophagus (BE) goes through a sequence of low grade dysplasia (LGD) and high grade dysplasia (HGD) to esophageal adenocarcinoma (EAC). The current gold standard for BE outcome prediction, histopathological staging, can be unreliable. TP53 abnormalities may serve as prognostic biomarkers. TP53 protein accumulation detected by immunohistochemistry (IHC) indirectly assesses TP53 mutations. DNA fluorescent in situ hybridization (FISH) on brush cytology specimens directly evaluates gene locus loss. We evaluated if IHC and FISH are complementary tools to assess TP53 abnormalities and tested their prognostic value in a long-term prospective follow-up of a BE cohort. TP53 IHC on tissue sections and FISH on brush cytology specimens were evaluated for 116 BE patients with respect to the different histological stages. The TP53 abnormalities were further studied in a panel of cell lines representative of the Barrett's carcinogenic sequence. For 91patients, the predictive value of TP53 abnormalities with respect to progression to HGD/EAC was tested after long term follow-up. The frequency of IHC and FISH TP53 abnormalities increased significantly with increasing histological stage (P

Published
2015

4. Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus

Author

Martinez, Pierre, primary, Timmer, Margriet R., additional, Lau, Chiu T., additional, Calpe, Silvia, additional, Sancho-Serra, Maria del Carmen, additional, Straub, Danielle, additional, Baker, Ann-Marie, additional, Meijer, Sybren L., additional, Kate, Fiebo J. W. ten, additional, Mallant-Hent, Rosalie C., additional, Naber, Anton H. J., additional, van Oijen, Arnoud H. A. M., additional, Baak, Lubbertus C., additional, Scholten, Pieter, additional, Böhmer, Clarisse J. M., additional, Fockens, Paul, additional, Bergman, Jacques J. G. H. M., additional, Maley, Carlo C., additional, Graham, Trevor A., additional, and Krishnadath, Kausilia K, additional

Published
2016
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5. 139 Longitudinal Single Cell Clonal Analysis Reveals Evolutionary Stasis and Re-Determined Malignant Potential in Non-Dysplastic Barrett's Esophagus

Author

Timmer, Margriet R., primary, Martinez, Pierre, additional, Lau, Liana, additional, Meijer, Sybren L., additional, Ten Kate, Fiebo, additional, Mallant-Hent, Rosalie, additional, Naber, Anton H., additional, van Oijen, Martijn G., additional, Baak, Lubbertus C., additional, Scholten, Pieter, additional, Böhmer, Clarisse, additional, Fockens, Paul, additional, Bergman, Jacques, additional, Maley, Carlo, additional, Graham, Trevor A., additional, and Krishnadath, Kausilia K., additional

Published
2016
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7. Aberrant TP53 detected by combining immunohistochemistry and DNA-FISH improves Barrett's esophagus progression prediction: A prospective follow-up study

Author

Pathologie Pathologen staf, Pathologie, Davelaar, Akueni L., Calpe, Silvia, Lau, Liana, Timmer, Margriet R., Visser, Mike, ten Kate, Fiebo J., Parikh, Kaushal B., Meijer, Sybren L., Bergman, Jacques J., Fockens, Paul, Krishnadath, Kausilia K., Pathologie Pathologen staf, Pathologie, Davelaar, Akueni L., Calpe, Silvia, Lau, Liana, Timmer, Margriet R., Visser, Mike, ten Kate, Fiebo J., Parikh, Kaushal B., Meijer, Sybren L., Bergman, Jacques J., Fockens, Paul, and Krishnadath, Kausilia K.

Published
2015

8. Derivation of genetic biomarkers for cancer risk stratification in Barrett’s oesophagus: a prospective cohort study

Author

Timmer, Margriet R, primary, Martinez, Pierre, additional, Lau, Chiu T, additional, Westra, Wytske M, additional, Calpe, Silvia, additional, Rygiel, Agnieszka M, additional, Rosmolen, Wilda D, additional, Meijer, Sybren L, additional, ten Kate, Fiebo J W, additional, Dijkgraaf, Marcel G W, additional, Mallant-Hent, Rosalie C, additional, Naber, Anton H J, additional, van Oijen, Arnoud H A M, additional, Baak, Lubbertus C, additional, Scholten, Pieter, additional, Böhmer, Clarisse J M, additional, Fockens, Paul, additional, Maley, Carlo C, additional, Graham, Trevor A, additional, Bergman, Jacques J G H M, additional, and Krishnadath, Kausilia K, additional

Published
2015
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10. Recalcitrant plantar warts during azathioprine therapy for Crohn’s disease

Author

Timmer, Margriet R. and van Ooteghem, Nancy A.M.

Subjects
Crohn’s disease, plantar warts, Azathioprine, Case Report, human papillomavirus, digestive system diseases
Abstract

Dermatological complications of long-term immunosuppressive therapy in inflammatory bowel disease (IBD) are rarely reported. We present the case of a 29-year-old man with worsening of plantar warts while on azathioprine therapy for Crohn’s disease. This case underlines the need to perform thorough skin examination of IBD patients before and during immunosuppressive therapy.

Published
2013

11. Aberrant TP53 detected by combining immunohistochemistry and DNA‐FISH improves Barrett's esophagus progression prediction: A prospective follow‐up study

Author

Davelaar, Akueni L., primary, Calpe, Silvia, additional, Lau, Liana, additional, Timmer, Margriet R., additional, Visser, Mike, additional, ten Kate, Fiebo J., additional, Parikh, Kaushal B., additional, Meijer, Sybren L., additional, Bergman, Jacques J., additional, Fockens, Paul, additional, and Krishnadath, Kausilia K., additional

Published
2014
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12. Tu1311 A FISH Biomarker Panel for Distinguishing Different Stages of Dysplasia in Barrett's Esophagus

Author

Timmer, Margriet R., primary, Lau, Chiu Ting, additional, Rosmolen, Wilda, additional, Meijer, Sybren L., additional, Dijkgraaf, Marcel G., additional, Mallant-Hent, Rosalie C., additional, Naber, Anton H., additional, Van Oijen, Arnoud H., additional, Baak, Lubbertus C., additional, Scholten, Pieter, additional, BöHmer, Clarisse, additional, Fockens, Paul, additional, Bergman, Jacques J., additional, and Krishnadath, Kausilia K., additional

Published
2014
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13. 164 A FISH Biomarker Panel for the Prediction of High-grade Dysplasia and Adenocarcinoma in Non-Dysplastic Barrett's Esophagus; Results From a Long-Term Prospective Cohort Study

Author

Timmer, Margriet R., primary, Lau, Chiu Ting, additional, Rosmolen, Wilda, additional, Meijer, Sybren L., additional, Dijkgraaf, Marcel G., additional, Mallant-Hent, Rosalie C., additional, Naber, Anton H., additional, Van Oijen, Arnoud H., additional, Baak, Lubbertus C., additional, Scholten, Pieter, additional, BöHmer, Clarisse, additional, Fockens, Paul, additional, Bergman, Jacques J., additional, and Krishnadath, Kausilia K., additional

Published
2014
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21. Mo1923 Non-Dysplastic Barrett's Esophagus Is Not Created the Same: Genetic Abnormalities in Non-Dysplastic Barrett's Esophagus Are Dependent on Clinical Context

Author

Timmer, Margriet R., primary, Brankley, Shannon, additional, Gorospe, Emmanuel C., additional, Iyer, Prasad G., additional, Lutzke, Lori S., additional, Anderson, Marlys, additional, Krishnadath, Kausilia K., additional, Halling, Kevin C., additional, and Wang, Kenneth K., additional

Published
2013
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22. Derivation of genetic biomarkers for cancer risk stratification in Barrett's oesophagus: a prospective cohort study.

Author

Timmer, Margriet R., Martinez, Pierre, Lau, Chiu T., Westra, Wytske M., Calpe, Silvia, Rygiel, Agnieszka M., Rosmolen, Wilda D., Meijer, Sybren L., ten Kate, Fiebo J. W., Dijkgraaf, Marcel G. W., Mallant-Hent, Rosalie C., Naber, Anton H. J., van Oijen, Arnoud H. A. M., Baak, Lubbertus C., Scholten, Pieter, Böhmer, Clarisse J. M., Fockens, Paul, Maley, Carlo C., Graham, Trevor A., and Bergman, Jacques J. G. H. M.

Subjects
BARRETT'S esophagus, GENETIC markers, CANCER risk factors, DISEASE progression, ENDOSCOPY, DIAGNOSIS, THERAPEUTICS
Published
2016
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24. Aberrant TP53 detected by combining immunohistochemistry and DNA-FISH improves Barrett's esophagus progression prediction: a prospective follow-up study.

Author

Davelaar AL, Calpe S, Lau L, Timmer MR, Visser M, Ten Kate FJ, Parikh KB, Meijer SL, Bergman JJ, Fockens P, and Krishnadath KK

Subjects
Aged, Barrett Esophagus diagnosis, Barrett Esophagus pathology, Cell Line, Female, Follow-Up Studies, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prospective Studies, Tumor Suppressor Protein p53 metabolism, Barrett Esophagus genetics, Mutation, Tumor Suppressor Protein p53 genetics
Abstract

Barrett's esophagus (BE) goes through a sequence of low grade dysplasia (LGD) and high grade dysplasia (HGD) to esophageal adenocarcinoma (EAC). The current gold standard for BE outcome prediction, histopathological staging, can be unreliable. TP53 abnormalities may serve as prognostic biomarkers. TP53 protein accumulation detected by immunohistochemistry (IHC) indirectly assesses TP53 mutations. DNA fluorescent in situ hybridization (FISH) on brush cytology specimens directly evaluates gene locus loss. We evaluated if IHC and FISH are complementary tools to assess TP53 abnormalities and tested their prognostic value in a long-term prospective follow-up of a BE cohort. TP53 IHC on tissue sections and FISH on brush cytology specimens were evaluated for 116 BE patients with respect to the different histological stages. The TP53 abnormalities were further studied in a panel of cell lines representative of the Barrett's carcinogenic sequence. For 91patients, the predictive value of TP53 abnormalities with respect to progression to HGD/EAC was tested after long term follow-up. The frequency of IHC and FISH TP53 abnormalities increased significantly with increasing histological stage (P < 0.001, Chi(2) -test). Combining the techniques detected TP53 abnormalities in 100% of patients with LGD, HGD, and EAC. Multivariate analysis showed that IHC (hazard ratio: 17, 95% CI: 3.2-96, P = 0.001) and FISH (hazard ratio: 7.3, 95% CI: 1.3-41, P = 0.02) were both independent significant predictors of progression. Combining FISH and IHC in assessing TP53 abnormalities leads to an increased detection rate of TP53 aberrations and improved accuracy for predicting BE progression., (© 2014 Wiley Periodicals, Inc.)

Published
2015
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