1. Association between serum PCSK9 and coronary heart disease in patients with type 2 diabetes mellitus
- Author
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Juan Huang, Jun-Xu Gu, Kun Wang, Ai-Min Zhang, Ting-Ting Hong, Shan-Shan Li, Xiao-Qin Yao, Ming Yang, Yue Yin, Na Zhang, Ming Su, Jia-Jia Hu, Xue-Zhi Zhang, and Mei Jia
- Subjects
PCSK9 ,T2DM ,Coronary heart disease ,Cardiovascular events ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background and aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) is considered a new biomarker for atherosclerosis, but its ability to predict cardiovascular outcomes has been controversial. This study aimed to address the lack of data on PCSK9, coronary heart disease (CHD) severity, and major cardiovascular events (MACEs) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 2984 T2DM patients underwent selective coronary angiography, and their serum PCSK9 levels were measured using enzyme-linked immunosorbent assay. Correlation and logistic regression analyses were performed to investigate the association between PCSK9 expression and CHD severity. This study used Cox regression analysis to assess the association between circulating PCSK9 levels and the risk of MACEs. Results Circulating PCSK9 levels were significantly higher in the CHD group than in the non-CHD group [554.62 (265.11) ng/mL vs. 496.86 (129.05) ng/mL, p
- Published
- 2023
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