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1. Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors

Author

Gounder, Mrinal, Ratan, Ravin, Alcindor, Thierry, Schöffski, Patrick, van der Graaf, Winette T, Wilky, Breelyn A, Riedel, Richard F, Lim, Allison, Smith, L Mary, Moody, Stephanie, Attia, Steven, Chawla, Sant, D’Amato, Gina, Federman, Noah, Merriam, Priscilla, Van Tine, Brian A, Vincenzi, Bruno, Benson, Charlotte, Bui, Nam Quoc, Chugh, Rashmi, Tinoco, Gabriel, Charlson, John, Dileo, Palma, Hartner, Lee, Lapeire, Lore, Mazzeo, Filomena, Palmerini, Emanuela, Reichardt, Peter, Stacchiotti, Silvia, Bailey, Howard H, Burgess, Melissa A, Cote, Gregory M, Davis, Lara E, Deshpande, Hari, Gelderblom, Hans, Grignani, Giovanni, Loggers, Elizabeth, Philip, Tony, Pressey, Joseph G, Kummar, Shivaani, and Kasper, Bernd

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Aging, Pain Research, Clinical Trials and Supportive Activities, Patient Safety, Women's Health, Clinical Research, Cancer, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Female, Humans, Amyloid Precursor Protein Secretases, Antineoplastic Agents, Double-Blind Method, Fibromatosis, Aggressive, Gamma Secretase Inhibitors and Modulators, Progression-Free Survival, Quality of Life, Tetrahydronaphthalenes, Valine, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundDesmoid tumors are rare, locally aggressive, highly recurrent soft-tissue tumors without approved treatments.MethodsWe conducted a phase 3, international, double-blind, randomized, placebo-controlled trial of nirogacestat in adults with progressing desmoid tumors according to the Response Evaluation Criteria in Solid Tumors, version 1.1. Patients were assigned in a 1:1 ratio to receive the oral γ-secretase inhibitor nirogacestat (150 mg) or placebo twice daily. The primary end point was progression-free survival.ResultsFrom May 2019 through August 2020, a total of 70 patients were assigned to receive nirogacestat and 72 to receive placebo. Nirogacestat had a significant progression-free survival benefit over placebo (hazard ratio for disease progression or death, 0.29; 95% confidence interval, 0.15 to 0.55; P

Published
2023

4. Vimseltinib versus placebo for tenosynovial giant cell tumour (MOTION): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Author

Loong, Herbert, Brunello, Antonella, Krieg, Andreas, Algulnik, Mark, Riedel, Richard, Okuno, Scott, Loggers, Elizabeth, Alcindor, Thierry, Ferraresi, Virginia, Serrano, César, Randall, R. Lor, Wilky, Breelyn, Ravi, Vinod, Gelderblom, Hans, Bhadri, Vivek, Stacchiotti, Silvia, Bauer, Sebastian, Wagner, Andrew J, van de Sande, Michiel, Bernthal, Nicholas M, López Pousa, Antonio, Razak, Albiruni Abdul, Italiano, Antoine, Ahmed, Mahbubl, Le Cesne, Axel, Tinoco, Gabriel, Boye, Kjetil, Martín-Broto, Javier, Palmerini, Emanuela, Tafuto, Salvatore, Pratap, Sarah, Powers, Benjamin C, Reichardt, Peter, Casado Herráez, Antonio, Rutkowski, Piotr, Tait, Christopher, Zarins, Fiona, Harrow, Brooke, Sharma, Maitreyi G, Ruiz-Soto, Rodrigo, Sherman, Matthew L, Blay, Jean-Yves, and Tap, William D

Published
2024
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6. Mean platelet volume, thrombocytosis, and survival in non-small cell lung cancer patients treated with first-line pembrolizumab alone or with chemotherapy

Author

Li, Mingjia, Zhao, Songzhu, Lopez, Gabrielle, Secor, Austin, Das, Parthib, Surya, Nitya, Grogan, Madison, Patel, Sandip, Chakravarthy, Karthik, Miah, Abdul, Spakowicz, Daniel, Tinoco, Gabriel, Li, Zihai, Wei, Lai, He, Kai, Bertino, Erin, Alahmadi, Asrar, Memmott, Regan, Kaufman, Jacob, Shields, Peter G., Carbone, David P., Presley, Carolyn J., Otterson, Gregory A., and Owen, Dwight H.

Published
2023
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9. Two national mammography quality certification programs in Brazil: Framework and main outcomes between 2017 and 2021

Author

da Silva, Sonia Maria, Peixoto, João Emilio, Aduan, Flávia Engel, Urban, Linei Augusta, Travassos, Leonardo Vieira, Canella, Ellyete Oliveira, Rego, Salete Fonseca, Campos, Alex Camara, Araújo, Anna Maria, Schaefer, Marcela Brisighelli, Kefalas, Ana Lucia, Francisco, José Luis, Maranhão, Norma Medicis, dos Santos, Radiá Pereira, di Pace Bauab, Selma, Kalaf, José Michel, Chala, Luciano Fernades, Couto, Henrique Lima, Jakubiak, Rosangela Requi, and Tinoco, Gabriel Wingler

Published
2023
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12. A Single-Arm Phase 2 Trial of Trametinib in Patients with Locally Advanced or Metastatic Epithelioid Hemangioendothelioma

Author

Schuetze, Scott M., primary, Ballman, Karla V., additional, Heise, Rachel, additional, Ganjoo, Kristen N., additional, Davis, Elizabeth J., additional, George, Suzanne, additional, Burgess, Melissa A., additional, Choy, Edwin, additional, Shepard, Dale R., additional, Tinoco, Gabriel, additional, Hirbe, Angela, additional, Kelly, Ciara M., additional, Attia, Steven, additional, Deshpande, Hari A., additional, Schwartz, Gary K., additional, Siontis, Brittany L., additional, Riedel, Richard F., additional, von Mehren, Margaret, additional, Kozlowski, Erin, additional, Chen, Helen X., additional, Astbury, Caroline, additional, and Rubin, Brian P., additional

Published
2024
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13. First Description of the Clinical Activity of Avapritinib in Sporadic Mesenteric Desmoid Tumor.

Author

Ganzon, Rebecca, Chen, Wei, Tinoco, Gabriel, and Mayordomo, Jose I.

Subjects
DESMOID tumors, PROTEIN-tyrosine kinase inhibitors, SURGICAL excision, SMALL intestine, PATHOLOGY, GASTROINTESTINAL stromal tumors
Abstract

Desmoid tumors (DTs) are rare and locally aggressive with a high rate of local recurrence even with optimal surgical resection. Systemic treatments are often utilized for desmoid cases with high risk of surgical morbidity or for local and symptomatic control of recurrent disease. However, the systemic treatment options for DTs are limited with limited responses. Avapritinib is a tyrosine kinase inhibitor (TKI) approved in 2020 for adults with unresectable or metastatic gastrointestinal (GI) stromal tumors (GISTs) harboring a platelet‐derived growth factor receptor alpha (PDGFRA) Exon 18 mutation, including D842V mutations. In this case report, we describe a 55‐year‐old man with a history of D842V‐mutant gastric GIST who presented several years after complete resection of the GIST with an enlarging soft tissue mass in the small intestine. After a nondiagnostic biopsy, the patient was started on avapritinib due to concerns for recurrent D842V‐mutant GIST. The tumor had a partial response to treatment by RECIST 1.1 criteria, and the patient underwent surgical resection. The final pathology report revealed a sporadic DT. To our knowledge, this is the first known description of the activity of avapritinib in the treatment of a sporadic mesenteric DT, which is relevant given the limited treatment options for patients with this diagnosis. This clinical finding may be worth exploring in a dedicated clinical trial. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Scalp Irradiation with 3D-Milled Bolus: Initial Dosimetric and Clinical Experience

Author

Dibs, Khaled, primary, Gogineni, Emile, additional, Jhawar, Sachin M., additional, Baliga, Sujith, additional, Grecula, John C., additional, Mitchell, Darrion L., additional, Palmer, Joshua, additional, Haglund, Karl, additional, Andraos, Therese Youssef, additional, Zoller, Wesley, additional, Ewing, Ashlee, additional, Bonomi, Marcelo, additional, Bhateja, Priyanka, additional, Tinoco, Gabriel, additional, Liebner, David, additional, Rocco, James W., additional, Old, Matthew, additional, Gamez, Mauricio E., additional, Chakravarti, Arnab, additional, Konieczkowski, David J., additional, and Blakaj, Dukagjin M., additional

Published
2024
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16. Supplementary Table 3 from A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Author

Wang, Cankun, primary, Ma, Anjun, primary, Li, Yingjie, primary, McNutt, Megan E., primary, Zhang, Shiqi, primary, Zhu, Jiangjiang, primary, Hoyd, Rebecca, primary, Wheeler, Caroline E., primary, Robinson, Lary A., primary, Chan, Carlos H.F., primary, Zakharia, Yousef, primary, Dodd, Rebecca D., primary, Ulrich, Cornelia M., primary, Hardikar, Sheetal, primary, Churchman, Michelle L., primary, Tarhini, Ahmad A., primary, Singer, Eric A., primary, Ikeguchi, Alexandra P., primary, McCarter, Martin D., primary, Denko, Nicholas, primary, Tinoco, Gabriel, primary, Husain, Marium, primary, Jin, Ning, primary, Osman, Afaf E.G., primary, Eljilany, Islam, primary, Tan, Aik Choon, primary, Coleman, Samuel S., primary, Denko, Louis, primary, Riedlinger, Gregory, primary, Schneider, Bryan P., primary, Spakowicz, Daniel, primary, and Ma, Qin, primary

Published
2024
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17. FIGURE 2 from A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Author

Wang, Cankun, primary, Ma, Anjun, primary, Li, Yingjie, primary, McNutt, Megan E., primary, Zhang, Shiqi, primary, Zhu, Jiangjiang, primary, Hoyd, Rebecca, primary, Wheeler, Caroline E., primary, Robinson, Lary A., primary, Chan, Carlos H.F., primary, Zakharia, Yousef, primary, Dodd, Rebecca D., primary, Ulrich, Cornelia M., primary, Hardikar, Sheetal, primary, Churchman, Michelle L., primary, Tarhini, Ahmad A., primary, Singer, Eric A., primary, Ikeguchi, Alexandra P., primary, McCarter, Martin D., primary, Denko, Nicholas, primary, Tinoco, Gabriel, primary, Husain, Marium, primary, Jin, Ning, primary, Osman, Afaf E.G., primary, Eljilany, Islam, primary, Tan, Aik Choon, primary, Coleman, Samuel S., primary, Denko, Louis, primary, Riedlinger, Gregory, primary, Schneider, Bryan P., primary, Spakowicz, Daniel, primary, and Ma, Qin, primary

Published
2024
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18. Supplementary Table 5 from A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Author

Wang, Cankun, primary, Ma, Anjun, primary, Li, Yingjie, primary, McNutt, Megan E., primary, Zhang, Shiqi, primary, Zhu, Jiangjiang, primary, Hoyd, Rebecca, primary, Wheeler, Caroline E., primary, Robinson, Lary A., primary, Chan, Carlos H.F., primary, Zakharia, Yousef, primary, Dodd, Rebecca D., primary, Ulrich, Cornelia M., primary, Hardikar, Sheetal, primary, Churchman, Michelle L., primary, Tarhini, Ahmad A., primary, Singer, Eric A., primary, Ikeguchi, Alexandra P., primary, McCarter, Martin D., primary, Denko, Nicholas, primary, Tinoco, Gabriel, primary, Husain, Marium, primary, Jin, Ning, primary, Osman, Afaf E.G., primary, Eljilany, Islam, primary, Tan, Aik Choon, primary, Coleman, Samuel S., primary, Denko, Louis, primary, Riedlinger, Gregory, primary, Schneider, Bryan P., primary, Spakowicz, Daniel, primary, and Ma, Qin, primary

Published
2024
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19. Supplementary Table 1 from A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Author

Wang, Cankun, primary, Ma, Anjun, primary, Li, Yingjie, primary, McNutt, Megan E., primary, Zhang, Shiqi, primary, Zhu, Jiangjiang, primary, Hoyd, Rebecca, primary, Wheeler, Caroline E., primary, Robinson, Lary A., primary, Chan, Carlos H.F., primary, Zakharia, Yousef, primary, Dodd, Rebecca D., primary, Ulrich, Cornelia M., primary, Hardikar, Sheetal, primary, Churchman, Michelle L., primary, Tarhini, Ahmad A., primary, Singer, Eric A., primary, Ikeguchi, Alexandra P., primary, McCarter, Martin D., primary, Denko, Nicholas, primary, Tinoco, Gabriel, primary, Husain, Marium, primary, Jin, Ning, primary, Osman, Afaf E.G., primary, Eljilany, Islam, primary, Tan, Aik Choon, primary, Coleman, Samuel S., primary, Denko, Louis, primary, Riedlinger, Gregory, primary, Schneider, Bryan P., primary, Spakowicz, Daniel, primary, and Ma, Qin, primary

Published
2024
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20. Supplementary Figure 1 from A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Author

Wang, Cankun, primary, Ma, Anjun, primary, Li, Yingjie, primary, McNutt, Megan E., primary, Zhang, Shiqi, primary, Zhu, Jiangjiang, primary, Hoyd, Rebecca, primary, Wheeler, Caroline E., primary, Robinson, Lary A., primary, Chan, Carlos H.F., primary, Zakharia, Yousef, primary, Dodd, Rebecca D., primary, Ulrich, Cornelia M., primary, Hardikar, Sheetal, primary, Churchman, Michelle L., primary, Tarhini, Ahmad A., primary, Singer, Eric A., primary, Ikeguchi, Alexandra P., primary, McCarter, Martin D., primary, Denko, Nicholas, primary, Tinoco, Gabriel, primary, Husain, Marium, primary, Jin, Ning, primary, Osman, Afaf E.G., primary, Eljilany, Islam, primary, Tan, Aik Choon, primary, Coleman, Samuel S., primary, Denko, Louis, primary, Riedlinger, Gregory, primary, Schneider, Bryan P., primary, Spakowicz, Daniel, primary, and Ma, Qin, primary

Published
2024
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21. FIGURE 1 from A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Author

Wang, Cankun, primary, Ma, Anjun, primary, Li, Yingjie, primary, McNutt, Megan E., primary, Zhang, Shiqi, primary, Zhu, Jiangjiang, primary, Hoyd, Rebecca, primary, Wheeler, Caroline E., primary, Robinson, Lary A., primary, Chan, Carlos H.F., primary, Zakharia, Yousef, primary, Dodd, Rebecca D., primary, Ulrich, Cornelia M., primary, Hardikar, Sheetal, primary, Churchman, Michelle L., primary, Tarhini, Ahmad A., primary, Singer, Eric A., primary, Ikeguchi, Alexandra P., primary, McCarter, Martin D., primary, Denko, Nicholas, primary, Tinoco, Gabriel, primary, Husain, Marium, primary, Jin, Ning, primary, Osman, Afaf E.G., primary, Eljilany, Islam, primary, Tan, Aik Choon, primary, Coleman, Samuel S., primary, Denko, Louis, primary, Riedlinger, Gregory, primary, Schneider, Bryan P., primary, Spakowicz, Daniel, primary, and Ma, Qin, primary

Published
2024
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22. Supplementary Table 6 from A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Author

Wang, Cankun, primary, Ma, Anjun, primary, Li, Yingjie, primary, McNutt, Megan E., primary, Zhang, Shiqi, primary, Zhu, Jiangjiang, primary, Hoyd, Rebecca, primary, Wheeler, Caroline E., primary, Robinson, Lary A., primary, Chan, Carlos H.F., primary, Zakharia, Yousef, primary, Dodd, Rebecca D., primary, Ulrich, Cornelia M., primary, Hardikar, Sheetal, primary, Churchman, Michelle L., primary, Tarhini, Ahmad A., primary, Singer, Eric A., primary, Ikeguchi, Alexandra P., primary, McCarter, Martin D., primary, Denko, Nicholas, primary, Tinoco, Gabriel, primary, Husain, Marium, primary, Jin, Ning, primary, Osman, Afaf E.G., primary, Eljilany, Islam, primary, Tan, Aik Choon, primary, Coleman, Samuel S., primary, Denko, Louis, primary, Riedlinger, Gregory, primary, Schneider, Bryan P., primary, Spakowicz, Daniel, primary, and Ma, Qin, primary

Published
2024
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23. Supplementary Table 4 from A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Author

Wang, Cankun, primary, Ma, Anjun, primary, Li, Yingjie, primary, McNutt, Megan E., primary, Zhang, Shiqi, primary, Zhu, Jiangjiang, primary, Hoyd, Rebecca, primary, Wheeler, Caroline E., primary, Robinson, Lary A., primary, Chan, Carlos H.F., primary, Zakharia, Yousef, primary, Dodd, Rebecca D., primary, Ulrich, Cornelia M., primary, Hardikar, Sheetal, primary, Churchman, Michelle L., primary, Tarhini, Ahmad A., primary, Singer, Eric A., primary, Ikeguchi, Alexandra P., primary, McCarter, Martin D., primary, Denko, Nicholas, primary, Tinoco, Gabriel, primary, Husain, Marium, primary, Jin, Ning, primary, Osman, Afaf E.G., primary, Eljilany, Islam, primary, Tan, Aik Choon, primary, Coleman, Samuel S., primary, Denko, Louis, primary, Riedlinger, Gregory, primary, Schneider, Bryan P., primary, Spakowicz, Daniel, primary, and Ma, Qin, primary

Published
2024
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24. Supplementary Table 2 from A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Author

Wang, Cankun, primary, Ma, Anjun, primary, Li, Yingjie, primary, McNutt, Megan E., primary, Zhang, Shiqi, primary, Zhu, Jiangjiang, primary, Hoyd, Rebecca, primary, Wheeler, Caroline E., primary, Robinson, Lary A., primary, Chan, Carlos H.F., primary, Zakharia, Yousef, primary, Dodd, Rebecca D., primary, Ulrich, Cornelia M., primary, Hardikar, Sheetal, primary, Churchman, Michelle L., primary, Tarhini, Ahmad A., primary, Singer, Eric A., primary, Ikeguchi, Alexandra P., primary, McCarter, Martin D., primary, Denko, Nicholas, primary, Tinoco, Gabriel, primary, Husain, Marium, primary, Jin, Ning, primary, Osman, Afaf E.G., primary, Eljilany, Islam, primary, Tan, Aik Choon, primary, Coleman, Samuel S., primary, Denko, Louis, primary, Riedlinger, Gregory, primary, Schneider, Bryan P., primary, Spakowicz, Daniel, primary, and Ma, Qin, primary

Published
2024
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25. Data from A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Author

Wang, Cankun, primary, Ma, Anjun, primary, Li, Yingjie, primary, McNutt, Megan E., primary, Zhang, Shiqi, primary, Zhu, Jiangjiang, primary, Hoyd, Rebecca, primary, Wheeler, Caroline E., primary, Robinson, Lary A., primary, Chan, Carlos H.F., primary, Zakharia, Yousef, primary, Dodd, Rebecca D., primary, Ulrich, Cornelia M., primary, Hardikar, Sheetal, primary, Churchman, Michelle L., primary, Tarhini, Ahmad A., primary, Singer, Eric A., primary, Ikeguchi, Alexandra P., primary, McCarter, Martin D., primary, Denko, Nicholas, primary, Tinoco, Gabriel, primary, Husain, Marium, primary, Jin, Ning, primary, Osman, Afaf E.G., primary, Eljilany, Islam, primary, Tan, Aik Choon, primary, Coleman, Samuel S., primary, Denko, Louis, primary, Riedlinger, Gregory, primary, Schneider, Bryan P., primary, Spakowicz, Daniel, primary, and Ma, Qin, primary

Published
2024
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26. FIGURE 3 from A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Author

Wang, Cankun, primary, Ma, Anjun, primary, Li, Yingjie, primary, McNutt, Megan E., primary, Zhang, Shiqi, primary, Zhu, Jiangjiang, primary, Hoyd, Rebecca, primary, Wheeler, Caroline E., primary, Robinson, Lary A., primary, Chan, Carlos H.F., primary, Zakharia, Yousef, primary, Dodd, Rebecca D., primary, Ulrich, Cornelia M., primary, Hardikar, Sheetal, primary, Churchman, Michelle L., primary, Tarhini, Ahmad A., primary, Singer, Eric A., primary, Ikeguchi, Alexandra P., primary, McCarter, Martin D., primary, Denko, Nicholas, primary, Tinoco, Gabriel, primary, Husain, Marium, primary, Jin, Ning, primary, Osman, Afaf E.G., primary, Eljilany, Islam, primary, Tan, Aik Choon, primary, Coleman, Samuel S., primary, Denko, Louis, primary, Riedlinger, Gregory, primary, Schneider, Bryan P., primary, Spakowicz, Daniel, primary, and Ma, Qin, primary

Published
2024
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27. Supplementary Table 7 from A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset

Author

Wang, Cankun, primary, Ma, Anjun, primary, Li, Yingjie, primary, McNutt, Megan E., primary, Zhang, Shiqi, primary, Zhu, Jiangjiang, primary, Hoyd, Rebecca, primary, Wheeler, Caroline E., primary, Robinson, Lary A., primary, Chan, Carlos H.F., primary, Zakharia, Yousef, primary, Dodd, Rebecca D., primary, Ulrich, Cornelia M., primary, Hardikar, Sheetal, primary, Churchman, Michelle L., primary, Tarhini, Ahmad A., primary, Singer, Eric A., primary, Ikeguchi, Alexandra P., primary, McCarter, Martin D., primary, Denko, Nicholas, primary, Tinoco, Gabriel, primary, Husain, Marium, primary, Jin, Ning, primary, Osman, Afaf E.G., primary, Eljilany, Islam, primary, Tan, Aik Choon, primary, Coleman, Samuel S., primary, Denko, Louis, primary, Riedlinger, Gregory, primary, Schneider, Bryan P., primary, Spakowicz, Daniel, primary, and Ma, Qin, primary

Published
2024
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28. A bioinformatics tool for identifying intratumoral microbes from the ORIEN dataset

Author

Wang, Cankun, primary, Ma, Anjun, additional, Li, Yingjie, additional, McNutt, Megan E., additional, Zhang, Shiqi, additional, Zhu, Jiangjiang, additional, Hoyd, Rebecca, additional, Wheeler, Caroline E, additional, Robinson, Lary A, additional, Chan, Carlos H.F., additional, Zakharia, Yousef, additional, Dodd, Rebecca D., additional, Ulrich, Cornelia M, additional, Hardikar, Sheetal, additional, Churchman, Michelle L, additional, Tarhini, Ahmad A, additional, Singer, Eric A, additional, Ikeguchi, Alexandra P, additional, McCarter, Martin D., additional, Denko, Nicholas, additional, Tinoco, Gabriel, additional, Husain, Marium, additional, Jin, Ning, additional, Osman, Afaf E.G., additional, Eljilany, Islam, additional, Tan, Aik Choon, additional, Coleman, Samuel S, additional, Denko, Louis, additional, Riedlinger, Gregory, additional, Schneider, Bryan P., additional, Spakowicz, Daniel, additional, and Ma, Qin, additional

Published
2024
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30. Vimseltinib versus placebo for tenosynovial giant cell tumour (MOTION): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Author

Gelderblom, Hans, Bhadri, Vivek, Stacchiotti, Silvia, Bauer, Sebastian, Wagner, Andrew J, van de Sande, Michiel, Bernthal, Nicholas M, López Pousa, Antonio, Razak, Albiruni Abdul, Italiano, Antoine, Ahmed, Mahbubl, Le Cesne, Axel, Tinoco, Gabriel, Boye, Kjetil, Martín-Broto, Javier, Palmerini, Emanuela, Tafuto, Salvatore, Pratap, Sarah, Powers, Benjamin C, Reichardt, Peter, Casado Herráez, Antonio, Rutkowski, Piotr, Tait, Christopher, Zarins, Fiona, Harrow, Brooke, Sharma, Maitreyi G, Ruiz-Soto, Rodrigo, Sherman, Matthew L, Blay, Jean-Yves, Tap, William D, Loong, Herbert, Brunello, Antonella, Krieg, Andreas, Algulnik, Mark, Riedel, Richard, Okuno, Scott, Loggers, Elizabeth, Alcindor, Thierry, Ferraresi, Virginia, Serrano, César, Randall, R. Lor, Wilky, Breelyn, and Ravi, Vinod

Abstract

Tenosynovial giant cell tumour (TGCT) is a locally aggressive neoplasm for which few systemic treatment options exist. This study evaluated the efficacy and safety of vimseltinib, an oral, switch-control, CSF1R inhibitor, in patients with symptomatic TGCT not amenable to surgery.

Published
2024
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31. Clinical Characteristics, Patterns of Care, and Treatment Outcomes of Radiation-Associated Sarcomas.

Author

Raj, Rohit, Kim, Han Gil, Xu, Menglin, Roach, Tyler, Liebner, David, Konieczkowski, David, and Tinoco, Gabriel

Subjects
OSTEOSARCOMA, SARCOMA, GENOMICS, RESEARCH funding, CANCER patient medical care, BREAST tumors, SYMPTOMS, TREATMENT effectiveness, CANCER patients, RETROSPECTIVE studies, DESCRIPTIVE statistics, RADIATION dosimetry, KAPLAN-Meier estimator, LOG-rank test, METASTASIS, MEDICAL records, ACQUISITION of data, RADIATION carcinogenesis, GENETIC mutation, PROGRESSION-free survival, RADIATION doses, SURVIVAL analysis (Biometry), CONFIDENCE intervals, OVERALL survival, PROPORTIONAL hazards models
Abstract

Simple Summary: Radiation-associated sarcomas pose a significant clinical challenge due to their complexity, aggressiveness, and poor prognosis. Our retrospective study is one of the largest descriptions of radiation-associated sarcomas, aiming to shed light on their clinicopathologic characteristics and highlight treatment approaches. Our research found a significant association between high radiation-associated sarcoma histologic grade and inferior clinical outcomes. We also found that localized radiation-associated sarcoma patients who underwent margin-negative resections lived significantly longer than their counterparts. Our analysis thus confirms the paramount role of tumor grade and the central importance of margin-negative oncologic resection in determining clinical outcomes for radiation-associated sarcomas. Radiation-associated sarcomas (RASs) are rare tumors with limited contemporary data to inform prognostication and management. We sought to identify the clinical presentation, patterns of care, and prognostic factors of RASs. RAS patients treated at a single institution from 2015 to 2021 were retrospectively reviewed for clinicopathologic variables, treatment strategies, and outcomes. Thirty-eight patients were identified with a median follow-up of 30.5 months. The median age at RAS diagnosis was 68.4 years (27.9–85.4), with a median latency from index radiotherapy (RT) of 9.1 years (3.7–46.3). RAS histologies included angiosarcoma (26%), undifferentiated pleomorphic sarcoma (21%), and osteosarcoma (18%). Most were high-grade (76%). Genomic profiling revealed low tumor mutational burden, frequent inactivating TP53 mutations (44%), CDKN2A deletions (26%), and MYC amplifications (22%), particularly in breast angiosarcomas. Of 38 patients, 33 presented with localized disease, 26 of whom were treated with curative intent. Overall, the median progression-free survival (PFS) was 9.5 months (1.4–34.7), and the overall survival (OS) was 11.1 months (0.6–31.6). Patients with localized vs. metastatic RASs had a longer PFS (HR, 3.0 [1.1–8.5]; p = 0.03) and OS (HR, 3.0 [1.04–8.68]; p = 0.03). Among localized RAS patients, high grade was associated with shorter OS (HR, 4.6 [1.04–20.30]; p = 0.03) and resection with longer OS (mean 58.8 vs. 6.1 months, HR, 0.1 [0.03–0.28]; p < 0.001). Among patients undergoing resection, negative margins were associated with improved OS (mean 71.0 vs. 15.5 months, HR, 5.1 [1.4–18.2]; p = 0.006). Patients with localized disease, particularly those undergoing R0 resection, demonstrated significantly better outcomes. Novel strategies are urgently needed to improve treatment outcomes in this challenging group of diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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33. The tumor microbiome reacts to hypoxia and can influence response to radiation treatment in colorectal cancer

Author

Benej, Martin, primary, Hoyd, Rebecca, additional, Kreamer, McKenzie, additional, Wheeler, Caroline E., additional, Grencewicz, Dennis J., additional, Choueiry, Fouad, additional, Chan, Carlos HF, additional, Zakharia, Yousef, additional, Ma, Qin, additional, Dodd, Rebecca D., additional, Ulrich, Cornelia M., additional, Hardikar, Sheetal, additional, Churchman, Michelle L., additional, Tarhini, Ahmad A., additional, Robinson, Lary A., additional, Singer, Eric A., additional, Ikeguchi, Alexandra P., additional, McCarter, Martin D., additional, Tinoco, Gabriel, additional, Husain, Marium, additional, Jin, Ning, additional, Tan, Aik Choon, additional, Osman, Afaf E.G., additional, Eljilany, Islam, additional, Riedlinger, Gregory, additional, Schneider, Brian P., additional, Benejova, Katarina, additional, Kery, Martin, additional, Papandreou, Ioanna, additional, Zhu, Jiangjiang, additional, Denko, Nicholas, additional, and Spakowicz, Daniel, additional

Published
2023
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38. Inferring the role of the microbiome on survival in patients treated with immune checkpoint inhibitors: causal modeling, timing, and classes of concomitant medications

Author

Spakowicz, Daniel, Hoyd, Rebecca, Muniak, Mitchell, Husain, Marium, Bassett, James S., Wang, Lei, Tinoco, Gabriel, Patel, Sandip H., Burkart, Jarred, Miah, Abdul, Li, Mingjia, Johns, Andrew, Grogan, Madison, Carbone, David P., Verschraegen, Claire F., Kendra, Kari L., Otterson, Gregory A., Li, Lang, Presley, Carolyn J., and Owen, Dwight H.

Published
2020
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39. The tumor microbiome as a predictor of outcomes in patients with metastatic melanoma treated with immune checkpoint inhibitors

Author

Wheeler, Caroline E., primary, Coleman,, Samuel S., additional, Hoyd, Rebecca, additional, Denko, Louis, additional, Chan, Carlos H.F., additional, Churchman, Michelle L., additional, Denko, Nicholas, additional, Dodd, Rebecca D., additional, Eljilany, Islam, additional, Hardikar, Sheetal, additional, Husain, Marium, additional, Ikeguchi, Alexandra P., additional, Jin, Ning, additional, Ma, Qin, additional, McCarter, Martin D., additional, Osman, Afaf E.G., additional, Robinson, Lary A., additional, Singer, Eric A., additional, Tinoco, Gabriel, additional, Ulrich, Cornelia M., additional, Zakharia, Yousef, additional, Spakowicz, Daniel, additional, Tarhini, Ahmad A., additional, and Tan, Aik Choon, additional

Published
2023
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40. A bioinformatics tool for identifying intratumoral microbes from the ORIEN dataset

Author

Wang, Cankun, primary, Ma, Anjun, additional, McNutt, Megan E., additional, Hoyd, Rebecca, additional, Wheeler, Caroline E., additional, Robinson, Lary A., additional, Chan, Carlos H.F., additional, Zakharia, Yousef, additional, Dodd, Rebecca D., additional, Ulrich, Cornelia M., additional, Hardikar, Sheetal, additional, Churchman, Michelle L., additional, Tarhini, Ahmad A., additional, Singer, Eric A., additional, Ikeguchi, Alexandra P., additional, McCarter, Martin D., additional, Denko, Nicholas, additional, Tinoco, Gabriel, additional, Husain, Marium, additional, Jin, Ning, additional, Osman, Afaf E.G., additional, Eljilany, Islam, additional, Tan, Aik Choon, additional, Coleman,, Samuel S., additional, Denko, Louis, additional, Riedlinger, Gregory, additional, Schneider, Bryan P., additional, Spakowicz, Daniel, additional, and Ma, Qin, additional

Published
2023
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45. 1311 The melanoma tumor microbiome as a predictor of outcomes in patients with metastatic disease treated with immune checkpoint inhibitors

Author

Wheeler, Caroline, primary, Hoyd, Rebecca, additional, Tan, Aik Choon, additional, Ulrich, Neli, additional, Tinoco, Gabriel, additional, Owen, Dwight, additional, Ose, Jennifer, additional, McCarter, Martin, additional, Sukrithan, Vineeth, additional, Ikeguchi, Alexandra, additional, Chan, Carlos, additional, Zakharia, Yousef, additional, Dodd, Rebecca, additional, Hardikar, Sheetal, additional, Weiner, George, additional, Kim, Youngchul, additional, Jin, Ning, additional, Liu, YunZhou, additional, Denko, Nicholas, additional, Husain, Marium, additional, Carpten, John, additional, Singer, Eric, additional, Robinson, Lary, additional, Dalton, William (Bill), additional, Churchman, Michelle, additional, Spakowicz, Daniel, additional, and Tarhini, Ahmad, additional

Published
2022
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48. Immune checkpoint inhibitor-induced hepatitis injury: risk factors, outcomes, and impact on survival

Author

Miah, Abdul, primary, Tinoco, Gabriel, additional, Zhao, Songzhu, additional, Wei, Lai, additional, Johns, Andrew, additional, Patel, Sandip, additional, Li, Mingjia, additional, Grogan, Madison, additional, Lopez, Gabrielle, additional, Husain, Marium, additional, Hoyd, Rebecca, additional, Mumtaz, Khalid, additional, Meara, Alexa, additional, Bertino, Erin M., additional, Kendra, Kari, additional, Spakowicz, Daniel, additional, Otterson, Gregory A., additional, Presley, Carolyn J., additional, and Owen, Dwight H., additional

Published
2022
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