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205 results on '"Tirone, Chiara"'

2. Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial

Author

Vento, Giovanni, Ventura, Maria Luisa, Pastorino, Roberta, van Kaam, Anton H, Carnielli, Virgilio, Cools, Filip, Dani, Carlo, Mosca, Fabio, Polglase, Graeme, Tagliabue, Paolo, Boni, Luca, Cota, Francesco, Tana, Milena, Tirone, Chiara, Aurilia, Claudia, Lio, Alessandra, Costa, Simonetta, D'Andrea, Vito, Lucente, Mariella, Nigro, Gabriella, Giordano, Lucio, Roma, Vincenzina, Villani, Paolo E, Fusco, Francesca P, Fasolato, Valeria, Colnaghi, Maria Rosa, Matassa, Piero G, Vendettuoli, Valentina, Poggi, Chiara, Del Vecchio, Antonio, Petrillo, Flavia, Betta, Pasqua, Mattia, Carmine, Garani, Giampaolo, Solinas, Agostina, Gitto, Eloisa, Salvo, Vincenzo, Gargano, Giancarlo, Balestri, Eleonora, Sandri, Fabrizio, Mescoli, Giovanna, Martinelli, Stefano, Ilardi, Laura, Ciarmoli, Elena, Di Fabio, Sandra, Maranella, Eugenia, Grassia, Carolina, Ausanio, Gaetano, Rossi, Vincenzo, Motta, Angela, Tina, Lucia G, Maiolo, Kim, Nobile, Stefano, Messner, Hubert, Staffler, Alex, Ferrero, Federica, Stasi, Ilaria, Pieragostini, Luisa, Mondello, Isabella, Haass, Cristina, Consigli, Chiara, Vedovato, Stefania, Grison, Alessandra, Maffei, Gianfranco, Presta, Giuseppe, Perniola, Roberto, Vitaliti, Marcello, Re, Maria P, De Curtis, Mario, Cardilli, Viviana, Lago, Paola, Tormena, Francesca, Orfeo, Luigi, Gizzi, Camilla, Massenzi, Luca, Gazzolo, Diego, Strozzi, Maria Chiara M, Bottino, Roberto, Pontiggia, Federica, Berardi, Alberto, Guidotti, Isotta, Cacace, Caterina, Meli, Valerio, Quartulli, Lorenzo, Scorrano, Antonio, Casati, Alessandra, Grappone, Lidia, and Pillow, J Jane

Published
2021
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4. Effects of early respiratory physiotherapy on spontaneous respiratory activity of preterm infants: study protocol for a randomized controlled trial

Author

Di Polito, Alessia, Del Vecchio, Arianna, Tana, Milena, Papacci, Patrizia, Vento, Anna Laura, Campagnola, Benedetta, Celona, Sefora, Cricenti, Laura, Bastoni, Ilaria, Tirone, Chiara, Lio, Alessandra, Aurilia, Claudia, Bottoni, Anthea, Paladini, Angela, Cota, Francesco, Ferrara, Paola Emilia, Ronconi, Gianpaolo, and Vento, Giovanni

Published
2021
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5. Thymosin β 4 and β 10 Expression in Human Organs during Development: A Review.

Author

Faa, Gavino, Messana, Irene, Coni, Pierpaolo, Piras, Monica, Pichiri, Giuseppina, Piludu, Marco, Iavarone, Federica, Desiderio, Claudia, Vento, Giovanni, Tirone, Chiara, Manconi, Barbara, Olianas, Alessandra, Contini, Cristina, Cabras, Tiziana, and Castagnola, Massimo

Subjects
ORGANS (Anatomy), THYMOSIN, GINGIVAL fluid, FETAL development, MORPHOGENESIS
Abstract

This review summarizes the results of a series of studies performed by our group with the aim to define the expression levels of thymosin β4 and thymosin β10 over time, starting from fetal development to different ages after birth, in different human organs and tissues. The first section describes the proteomics investigations performed on whole saliva from preterm newborns and gingival crevicular fluid, which revealed to us the importance of these acidic peptides and their multiple functions. These findings inspired us to start an in-depth investigation mainly based on immunochemistry to establish the distribution of thymosin β4 and thymosin β10 in different organs from adults and fetuses at different ages (after autopsy), and therefore to obtain suggestions on the functions of β-thymosins in health and disease. The functions of β-thymosins emerging from these studies, for instance, those performed during carcinogenesis, add significant details that could help to resolve the nowadays so-called "β-thymosin enigma", i.e., the potential molecular role played by these two pleiotropic peptides during human development. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Early Respiratory Physiotherapy versus an Individualized Postural Care Program for Reducing Mechanical Ventilation in Preterm Infants: A Randomised Controlled Trial

Author

Tana, Milena, primary, Bottoni, Anthea, additional, Cota, Francesco, additional, Papacci, Patrizia, additional, Di Polito, Alessia, additional, Del Vecchio, Arianna, additional, Vento, Anna Laura, additional, Campagnola, Benedetta, additional, Celona, Sefora, additional, Cricenti, Laura, additional, Bastoni, Ilaria, additional, Tirone, Chiara, additional, Aurilia, Claudia, additional, Lio, Alessandra, additional, Paladini, Angela, additional, Nobile, Stefano, additional, Perri, Alessandro, additional, Sbordone, Annamaria, additional, Esposito, Alice, additional, Fattore, Simona, additional, Ferrara, Paola Emilia, additional, Ronconi, Gianpaolo, additional, and Vento, Giovanni, additional

Published
2023
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9. The future of neonatal lung ultrasound: Validation of an artificial intelligence model for interpreting lung scans. A multicentre prospective diagnostic study

Author

Perri, Alessandro, Sbordone, Annamaria, Patti, Maria Letizia, Nobile, Stefano, Tirone, Chiara, Giordano, Lucia, Tana, Milena, D'Andrea, Vito, Priolo, Francesca, Serrao, Francesca, Riccardi, Riccardo, Prontera, Giorgia, Lenkowicz, Jacopo, Boldrini, Luca, Vento, Giovanni, Nobile, Stefano (ORCID:0000-0002-5304-1485), D'Andrea, Vito (ORCID:0000-0002-0980-799X), Riccardi, Riccardo (ORCID:0000-0001-7515-6622), Vento, Giovanni (ORCID:0000-0002-8132-5127), Perri, Alessandro, Sbordone, Annamaria, Patti, Maria Letizia, Nobile, Stefano, Tirone, Chiara, Giordano, Lucia, Tana, Milena, D'Andrea, Vito, Priolo, Francesca, Serrao, Francesca, Riccardi, Riccardo, Prontera, Giorgia, Lenkowicz, Jacopo, Boldrini, Luca, Vento, Giovanni, Nobile, Stefano (ORCID:0000-0002-5304-1485), D'Andrea, Vito (ORCID:0000-0002-0980-799X), Riccardi, Riccardo (ORCID:0000-0001-7515-6622), and Vento, Giovanni (ORCID:0000-0002-8132-5127)

Abstract

BackgroundArtificial intelligence (AI) is a promising field in the neonatal field. We focused on lung ultrasound (LU), a useful tool for the neonatologist. Our aim was to train a neural network to create a model able to interpret LU. MethodsOur multicentric, prospective study included newborns with gestational age (GA) & GE; 33 + 0 weeks with early tachypnea/dyspnea/oxygen requirements. For each baby, three LU were performed: within 3 h of life (T0), at 4-6 h of life (T1), and in the absence of respiratory support (T2). Each scan was processed to extract the region of interest used to train a neural network to classify it according to the LU score (LUS). We assessed sensitivity, specificity, positive and negative predictive value of the AI model's scores in predicting the need for respiratory assistance with nasal continuous positive airway pressure and for surfactant, compared to an already studied and established LUS. ResultsWe enrolled 62 newborns (GA = 36 & PLUSMN; 2 weeks). In the prediction of the need for CPAP, we found a cutoff of 6 (at T0) and 5 (at T1) for both the neonatal lung ultrasound score (nLUS) and AI score (AUROC 0.88 for T0 AI model, 0.80 for T1 AI model). For the outcome "need for surfactant therapy", results in terms of area under receiver operator characteristic (AUROC) are 0.84 for T0 AI model and 0.89 for T1 AI model. In the prediction of surfactant therapy, we found a cutoff of 9 for both scores at T0, at T1 the nLUS cutoff was 6, while the AI's one was 5. Classification accuracy was good both at the image and class levels. ConclusionsThis is, to our knowledge, the first attempt to use an AI model to interpret early neonatal LUS and can be extremely useful for neonatologists in the clinical setting.

Published
2023

11. The future of Neonatal Lung Ultrasound: validation of an Artificial Intelligence model for interpreting lung scans. A multicentre prospective diagnostic study.

Author

Sbordone, Annamaria, primary, Perri, Alessandro, additional, Patti, Maria Letizia, additional, Nobile, Stefano, additional, Tirone, Chiara, additional, Giordano, Lucia, additional, Tana, Milena, additional, D'Andrea, Vito, additional, Priolo, Francesca, additional, Serrao, Francesca, additional, Riccardi, Riccardo, additional, Prontera, Giorgia, additional, Lenkowicz, Jacopo, additional, Boldrini, Luca, additional, and Vento, Giovanni, additional

Published
2023
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12. Lowering of the Neonatal Lung Ultrasonography Score after nCPAP Positioning in Neonates over 32 Weeks of Gestational Age with Neonatal Respiratory Distress

Author

Perri, Alessandro, primary, Fattore, Simona, additional, D’Andrea, Vito, additional, Sbordone, Annamaria, additional, Patti, Maria Letizia, additional, Nobile, Stefano, additional, Tirone, Chiara, additional, Giordano, Lucia, additional, Tana, Milena, additional, Priolo, Francesca, additional, Serrao, Francesca, additional, Riccardi, Riccardo, additional, Prontera, Giorgia, additional, and Vento, Giovanni, additional

Published
2022
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13. Early lung ultrasound score to predict noninvasive ventilation needing in neonates from 33 weeks of gestational age: A multicentric study

Author

Perri, Alessandro, Annamaria, Sbordone, Maria, L Patti, Nobile, Stefano, Tirone, Chiara, Giordano, Lucia, Tana, Milena, D'Andrea, Vito, Priolo, Francesca, Serrao, Francesca, Riccardi, Riccardo, Prontera, Giorgia, Chiara, Maddaloni, Jacopo, Lenkowicz, Boldrini, Luca, nbsp, and Vento, Giovanni

Subjects
Pulmonary and Respiratory Medicine, Respiratory Distress Syndrome, Newborn, Noninvasive Ventilation, Infant, Newborn, Infant, Gestational Age, Pulmonary Surfactants, Surface-Active Agents, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, newborn, respiratory distress, Pediatrics, Perinatology and Child Health, score, Humans, Lung, lung ultrasound, Ultrasonography
Abstract

To propose an early lung ultrasound (LUS) score for the prediction of the need for respiratory assistance in newborns of gestational age (GA) ≥ 33 weeks presenting respiratory distress.Multicenter, prospective observational study in third-level neonatal intensive care units.Infants with GA ≥ 33 + 0 weeks with respiratory distress within 3 h of life.Three LUS for each patient were collected: within 3 h of life (T0), at 4-6 h of life (T1), and at the resolution of symptoms (T2). The primary aim was to assess the validity of the early LUS score in predicting the need for continuous positive airway pressure (CPAP). We also evaluated the validity of the score in predicting the need for surfactant, the scores' trend in our population, and any correlation with the duration of ventilation and oxygen therapy.Sixty-two patients were enrolled in the study. The mean GA was 36 weeks. The receiver operating characteristic analysis for the LUS T0 and T1 yielded area under the curves of 0.91 and 0.82 in predicting the need for CPAP, respectively. LUS score cut off of 6 (sensitivity 84.8%, specificity 86.2%) and 5 (sensitivity 66.7%, specificity 100%) were calculated at T0 and T1, respectively. We found significant correlations between LUS score and respiratory assistance, surfactant administration, and SpOAn early LUS score is a good noninvasive predictor of the need for respiratory assistance with CPAP and surfactant administration in newborns with GA ≥ 33 weeks.

Published
2022

14. The Relationship Between Maternal and Neonatal Microbiota in Spontaneous Preterm Birth: A Pilot Study

Author

Tirone, Chiara, primary, Paladini, Angela, additional, De Maio, Flavio, additional, Tersigni, Chiara, additional, D’Ippolito, Silvia, additional, Di Simone, Nicoletta, additional, Monzo, Francesca Romana, additional, Santarelli, Giulia, additional, Bianco, Delia Mercedes, additional, Tana, Milena, additional, Lio, Alessandra, additional, Menzella, Nicoletta, additional, Posteraro, Brunella, additional, Sanguinetti, Maurizio, additional, Lanzone, Antonio, additional, Scambia, Giovanni, additional, and Vento, Giovanni, additional

Published
2022
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15. Lowering of the Neonatal Lung Ultrasonography Score after nCPAP Positioning in Neonates over 32 Weeks of Gestational Age with Neonatal Respiratory Distress

Author

Perri, Alessandro, Fattore, Simona, D'Andrea, Vito, Sbordone, A., Patti, M. L., Nobile, Stefano, Tirone, Chiara, Giordano, Lucia, Tana, Milena, Priolo, Francesca, Serrao, Francesca, Riccardi, Riccardo, Prontera, Giorgia, Vento, Giovanni, Perri A., Fattore S., D'Andrea V. (ORCID:0000-0002-0980-799X), Nobile S. (ORCID:0000-0002-5304-1485), Tirone C., Giordano L., Tana M., Priolo F., Serrao F., Riccardi R. (ORCID:0000-0001-7515-6622), Prontera G., Vento G. (ORCID:0000-0002-8132-5127), Perri, Alessandro, Fattore, Simona, D'Andrea, Vito, Sbordone, A., Patti, M. L., Nobile, Stefano, Tirone, Chiara, Giordano, Lucia, Tana, Milena, Priolo, Francesca, Serrao, Francesca, Riccardi, Riccardo, Prontera, Giorgia, Vento, Giovanni, Perri A., Fattore S., D'Andrea V. (ORCID:0000-0002-0980-799X), Nobile S. (ORCID:0000-0002-5304-1485), Tirone C., Giordano L., Tana M., Priolo F., Serrao F., Riccardi R. (ORCID:0000-0001-7515-6622), Prontera G., and Vento G. (ORCID:0000-0002-8132-5127)

Abstract

Respiratory distress (RD) is one of the most common causes of admission to the neonatal intensive care unit. Correct diagnosis and timely intervention are crucial. Lung ultrasonography (LU) is a useful diagnostic tool for the neonatologist in the diagnosis of RD; the neonatal lung ultrasonography score (nLUS) can be used in the diagnostic process, but some authors hypothesise that it is also useful for the management of some neonatal RD. The aim of this study is to analyse the changes in nLUS score before (T0) and after (T1) the start of respiratory support with nasal CPAP in neonates over 32 weeks of age with RD. Thirty-three newborns were enrolled in this retrospective study. LU was performed before and after the start of CPAP. The median nLUS scores at T0 and T1 were 9 (IQR 7–12) and 7 (IQR 4–10), respectively, and showed a significant difference (p < 0.001). The magnitude of reduction in nLUS score, expressed as a percentage, was inversely related to the need for subsequent administration of exogenous surfactant. The study suggests the usefulness of the nLUS score in assessing the response to CPAP in neonates over 32 weeks gestational age.

Published
2022

16. The Surprising Composition of the Salivary Proteome of Preterm Human Newborn

Author

Castagnola, Massimo, Inzitari, Rosanna, Fanali, Chiara, Iavarone, Federica, Vitali, Alberto, Desiderio, Claudia, Vento, Giovanni, Tirone, Chiara, Romagnoli, Costantino, Cabras, Tiziana, Manconi, Barbara, Teresa Sanna, Maria, Boi, Roberto, Pisano, Elisabetta, Olianas, Alessandra, Pellegrini, Mariagiuseppina, Nemolato, Sonia, Wilhelm Heizmann, Claus, Faa, Gavino, and Messana, Irene

Published
2011
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17. Effects of High-Frequency Oscillatory Ventilation With Volume Guarantee During Surfactant Treatment in Extremely Low Gestational Age Newborns With Respiratory Distress Syndrome: An Observational Study

Author

Tana, Milena, primary, Paladini, Angela, additional, Tirone, Chiara, additional, Aurilia, Claudia, additional, Lio, Alessandra, additional, Bottoni, Anthea, additional, Costa, Simonetta, additional, Tiberi, Eloisa, additional, Pastorino, Roberta, additional, and Vento, Giovanni, additional

Published
2022
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18. Effects of Late Surfactant Treatment Delivered After a Recruitment Maneuver on Respiratory Outcomes in Extremely Low Gestational Age Newborns: A Randomized Controlled Pilot Trial – LATE-REC-SURF Trial.

Author

Lio, Alessandra, primary, Tirone, Chiara, additional, Tana, Milena, additional, Aurilia, Claudia, additional, Blandino, Rita, additional, De Tomaso, Davide, additional, Fusco, Francesca, additional, Paladini, Angela, additional, Nobile, Stefano, additional, Perri, Alessandro, additional, Cota, Francesco, additional, Pastorino, Roberta, additional, and Vento, Giovanni, additional

Published
2022
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19. Investigation by top‐down high‐performance liquid chromatography–mass spectrometry of glutathionylation and cysteinylation of salivary S100A9 and cystatin B in preterm newborns

Author

Boroumand, Mozghan, primary, Manconi, Barbara, additional, Serrao, Simone, additional, Iavarone, Federica, additional, Olianas, Alessandra, additional, Cabras, Tiziana, additional, Contini, Cristina, additional, Pieroni, Luisa, additional, Sanna, Maria Teresa, additional, Vento, Giovanni, additional, Tirone, Chiara, additional, Desiderio, Claudia, additional, Fiorita, Antonella, additional, Faa, Gavino, additional, Messana, Irene, additional, and Castagnola, Massimo, additional

Published
2021
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22. Effects of Early Respiratory Physiotherapy on Spontaneous Respiratory Activity of Preterm Infants: Study Protocol for a Randomized Controlled Trial

Author

Polito, Alessia Di, primary, Vecchio, Arianna Del, additional, Tana, Milena, additional, Papacci, Patrizia, additional, Vento, Anna Laura, additional, Campagnola, Benedetta, additional, Celona, Sefora, additional, Cricenti, Laura, additional, Bastoni, Ilaria, additional, Tirone, Chiara, additional, Lio, Alessandra, additional, Aurilia, Claudia, additional, Bottoni, Anthea, additional, Paladini, Angela, additional, Cota, Francesco, additional, Ferrara, Paola Emilia, additional, Ronconi, Gianpaolo, additional, and Vento, Giovanni, additional

Published
2021
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24. Oxidative and Proteolytic Inactivation of Alpha-1 Antitrypsin in Bronchopulmonary Dysplasia Pathogenesis: A Top-Down Proteomic Bronchoalveolar Lavage Fluid Analysis

Author

Tirone, Chiara, Iavarone, Federica, Tana, Milena, Lio, Alessandra, Aurilia, Claudia, Costa, Simonetta, Castagnola, Massimo, Messana, Irene, Vento, Giovanni, Tirone C., Iavarone F. (ORCID:0000-0002-2074-5531), Tana M., Lio A., Aurilia C., Costa S., Castagnola M. (ORCID:0000-0002-0959-7259), Messana I. (ORCID:0000-0002-1436-6105), Vento G. (ORCID:0000-0002-8132-5127), Tirone, Chiara, Iavarone, Federica, Tana, Milena, Lio, Alessandra, Aurilia, Claudia, Costa, Simonetta, Castagnola, Massimo, Messana, Irene, Vento, Giovanni, Tirone C., Iavarone F. (ORCID:0000-0002-2074-5531), Tana M., Lio A., Aurilia C., Costa S., Castagnola M. (ORCID:0000-0002-0959-7259), Messana I. (ORCID:0000-0002-1436-6105), and Vento G. (ORCID:0000-0002-8132-5127)

Abstract

The study investigates the role of the oxidative and proteolytic inactivation of alpha-1 antitrypsin (AAT) in the pathogenesis of bronchopulmonary dysplasia (BPD) in premature infants. Bronchoalveolar lavage fluid (BALF) samples were collected on the 3rd day of life from mechanically ventilated neonates with gestational age ≤ 30 weeks and analyzed without previous treatment (top-down proteomics) by reverse-phase high-performance liquid chromatography-electrospray ionization mass spectrometry. AAT fragments were identified by high-resolution LTQ Orbitrap XL experiments and the relative abundances determined by considering the extracted ion current (XIC) peak area. Forty preterm neonates were studied: 20 (50%) did not develop BPD (no-BPD group), 17 (42.5%) developed mild or moderate new-BPD (mild + moderate BPD group), and 3 (7.5%) developed severe new-BPD (severe BPD group). Eighteen fragments of AAT and a fragment of AAT oxidized at a methionine residue were identified: significantly higher values of AAT fragments 25–57, 375–418, 397–418, 144–171, and 397–418 with oxidized methionine were found in the severe BPD group. The significantly higher levels of several AAT fragments and of the fragment 397–418, oxidized in BALF of preterm infants developing BPD, underlie the central role of an imbalance between proteases and protease inhibitors in exacerbating lung injury and inducing most severe forms of BPD. The study has some limitations, and between them, the small sample size implies the need for further confirmation by larger studies.

Published
2021

25. Caution advised regarding lung recruitment before surfactant – Authors’ reply

Author

Vento, Giovanni, Ventura, M. L., Pastorino, Roberta, van Kaam, A. H., Carnielli, V., Cools, F., Dani, C., Mosca, F., Polglase, G., Tagliabue, P., Boni, L., Cota, Francesco, Tana, Milena, Tirone, Chiara, Aurilia, Claudia, Lio, Alessandra, Cost, S., D'Andrea, Vito, Lucente, Monica Christine, Nigro, G., Giordano, Lucia, Roma, V., Villani, P., Fusco, Francesca Paola, Fasolato, V., Colnaghi, M. R., Matassa, P. G., Vendettuoli, V., Poggi, C., Del Vecchi, A., Petrillo, F., Betta, P., Mattia, C., Garani, G., Solinas, A., Gitto, E., Salvo, V., Gargano, G., Balestri, E., Sandri, F., Mescoli, G., Martinelli, Silvia, Ilardi, L., Ciarmoli, E., Di Fabio, S., Maranella, E., Grassia, C., Ausanio, G., Rossi, V., Motta, A., Tina, L. G., Maiolo, K., Nobile, Stefano, Messner, H., Staffler, Alex, Ferrero, F., Stasi, I., Pieragostini, L., Mondello, I., Haass, C., Consigli, C., Vedovato, S., Grison, A., Maffei, G., Presta, G., Perniola, R., Vitaliti, M., Re, M. P., De Curtis, M., Cardilli, V., Lago, P., Tormena, F., Orfeo, L., Gizzi, C., Massenzi, L., Gazzolo, D., Strozzi, M. C. M., Bottino, R., Pontiggia, F., Berardi, A., Guidotti, I., Cacace, C., Meli, V., Quartulli, L., Scorrano, A., Casati, A., Grappone, L., Pillow, J. J., Vento G. (ORCID:0000-0002-8132-5127), Pastorino R. (ORCID:0000-0001-5013-0733), Cota F. (ORCID:0000-0002-9009-3997), Tana M., Tirone C., Aurilia C., Lio A., D'Andrea V. (ORCID:0000-0002-0980-799X), Lucente M., Giordano L., Fusco F. P., Martinelli S., Nobile S. (ORCID:0000-0002-5304-1485), Staffler A., Vento, Giovanni, Ventura, M. L., Pastorino, Roberta, van Kaam, A. H., Carnielli, V., Cools, F., Dani, C., Mosca, F., Polglase, G., Tagliabue, P., Boni, L., Cota, Francesco, Tana, Milena, Tirone, Chiara, Aurilia, Claudia, Lio, Alessandra, Cost, S., D'Andrea, Vito, Lucente, Monica Christine, Nigro, G., Giordano, Lucia, Roma, V., Villani, P., Fusco, Francesca Paola, Fasolato, V., Colnaghi, M. R., Matassa, P. G., Vendettuoli, V., Poggi, C., Del Vecchi, A., Petrillo, F., Betta, P., Mattia, C., Garani, G., Solinas, A., Gitto, E., Salvo, V., Gargano, G., Balestri, E., Sandri, F., Mescoli, G., Martinelli, Silvia, Ilardi, L., Ciarmoli, E., Di Fabio, S., Maranella, E., Grassia, C., Ausanio, G., Rossi, V., Motta, A., Tina, L. G., Maiolo, K., Nobile, Stefano, Messner, H., Staffler, Alex, Ferrero, F., Stasi, I., Pieragostini, L., Mondello, I., Haass, C., Consigli, C., Vedovato, S., Grison, A., Maffei, G., Presta, G., Perniola, R., Vitaliti, M., Re, M. P., De Curtis, M., Cardilli, V., Lago, P., Tormena, F., Orfeo, L., Gizzi, C., Massenzi, L., Gazzolo, D., Strozzi, M. C. M., Bottino, R., Pontiggia, F., Berardi, A., Guidotti, I., Cacace, C., Meli, V., Quartulli, L., Scorrano, A., Casati, A., Grappone, L., Pillow, J. J., Vento G. (ORCID:0000-0002-8132-5127), Pastorino R. (ORCID:0000-0001-5013-0733), Cota F. (ORCID:0000-0002-9009-3997), Tana M., Tirone C., Aurilia C., Lio A., D'Andrea V. (ORCID:0000-0002-0980-799X), Lucente M., Giordano L., Fusco F. P., Martinelli S., Nobile S. (ORCID:0000-0002-5304-1485), and Staffler A.

Abstract

N/A

Published
2021

27. Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates: 2-Year Follow-Up of a Randomized Clinical Trial.

Author

Gallini, Francesca, De Rose, Domenico Umberto, Iuliano, Roberta, Romeo, Domenico Marco, Tana, Milena, Paladini, Angela, Fusco, Francesca Paola, Nobile, Stefano, Cota, Francesco, Tirone, Chiara, Aurilia, Claudia, Lio, Alessandra, Esposito, Alice, Costa, Simonetta, D'Andrea, Vito, Ventura, Maria Luisa, Carnielli, Virgilio, Dani, Carlo, Mosca, Fabio, and Fumagalli, Monica

Published
2024
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30. Effect of Different Milk Diet on the Level of Fecal Calprotectin in Very Preterm Infants

Author

Costa, Simonetta, Patti, Maria Letizia, Perri, Alessandro, Cocca, C., Pinna, G., Tirone, Chiara, Tana, Milena, Lio, Alessandra, Vento, Giovanni, Costa S., Patti M. L., Perri A., Tirone C., Tana M., Lio A., Vento G. (ORCID:0000-0002-8132-5127), Costa, Simonetta, Patti, Maria Letizia, Perri, Alessandro, Cocca, C., Pinna, G., Tirone, Chiara, Tana, Milena, Lio, Alessandra, Vento, Giovanni, Costa S., Patti M. L., Perri A., Tirone C., Tana M., Lio A., and Vento G. (ORCID:0000-0002-8132-5127)

Abstract

Objective: To evaluate the course of fecal calprotectin (FC) in very preterm infants over the first 15 days of life in relation to the type of milk diet. Methods: This study was part of a randomized controlled trial comparing two different ways of integrating the own mother's milk (OMM) for the evaluation of feeding tolerance in very preterm infants. In infants with gestational age of ≤ 32 weeks randomized to receive preterm formula (PF group) or pasteurized donor human milk (PDHM group) as a supplement to the OMM insufficient or unavailable, FC level was planned to be measured at the first meconium passage and at days 8 and 15 of life (T0, T1, and T2, respectively). Results: FC data were available for all the 70 infants randomized, 35 in the PF group, and 35 in the PDHM group. The mean FC levels were similar in the two study groups at T0 and T1, whereas they were significantly higher in the PF group than the PDHM group at T2. FC values decreased over the first week of life in both groups and significantly increased over the second week of life only in the PF group. Conclusions: Our study demonstrates a significant increase in FC levels when PF is used as a supplement to the OMM compared to the use of PDHM. Further studies are needed to establish if the higher FC levels in infants receiving PF are the expression of a normal immunological maturation rather than an initial inflammatory process.

Published
2020

31. Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial

Author

Vento, Giovanni, Ventura, M. L., Pastorino, Roberta, van Kaam, A. H., Carnielli, V., Cools, F., Dani, C., Mosca, F., Polglase, G., Tagliabue, P., Boni, L., Cota, Francesco, Tana, Milena, Tirone, Chiara, Aurilia, Claudia, Lio, Alessandra, Costa, Simonetta, D'Andrea, Vito, Lucente, M., Nigro, G., Giordano, Liliana, Roma, V., Villani, P. E., Fusco, Francesca Paola, Fasolato, V., Colnaghi, M. R., Matassa, P. G., Vendettuoli, V., Poggi, C., Del Vecchio, Arianna, Petrillo, F., Betta, P., Mattia, C., Garani, G., Solinas, A., Gitto, E., Salvo, V., Gargano, G., Balestri, E., Sandri, F., Mescoli, G., Martinelli, S., Ilardi, L., Ciarmoli, E., Di Fabio, S., Maranella, E., Grassia, C., Ausanio, G., Rossi, V., Motta, Alessandro, Tina, L. G., Maiolo, K., Nobile, Stefano, Messner, H., Staffler, Alex, Ferrero, Mattia Francesco, Stasi, I., Pieragostini, L., Mondello, I., Haass, C., Consigli, C., Vedovato, S., Grison, A., Maffei, G., Presta, G., Perniola, R., Vitaliti, M., Re, M. P., De Curtis, M., Cardilli, V., Lago, P., Tormena, F., Orfeo, L., Gizzi, C., Massenzi, L., Gazzolo, D., Strozzi, M. C. M., Bottino, R., Pontiggia, F., Berardi, A., Guidotti, I., Cacace, C., Meli, V., Quartulli, L., Scorrano, A., Casati, A., Grappone, L., Pillow, J. J., Vento G. (ORCID:0000-0002-8132-5127), Pastorino R. (ORCID:0000-0001-5013-0733), Cota F. (ORCID:0000-0002-9009-3997), Tana M., Tirone C., Aurilia C., Lio A., Costa S., D'Andrea V. (ORCID:0000-0002-0980-799X), Giordano L., Fusco F. P., Del Vecchio A., Motta A., Nobile S. (ORCID:0000-0002-5304-1485), Staffler A., Ferrero F., Vento, Giovanni, Ventura, M. L., Pastorino, Roberta, van Kaam, A. H., Carnielli, V., Cools, F., Dani, C., Mosca, F., Polglase, G., Tagliabue, P., Boni, L., Cota, Francesco, Tana, Milena, Tirone, Chiara, Aurilia, Claudia, Lio, Alessandra, Costa, Simonetta, D'Andrea, Vito, Lucente, M., Nigro, G., Giordano, Liliana, Roma, V., Villani, P. E., Fusco, Francesca Paola, Fasolato, V., Colnaghi, M. R., Matassa, P. G., Vendettuoli, V., Poggi, C., Del Vecchio, Arianna, Petrillo, F., Betta, P., Mattia, C., Garani, G., Solinas, A., Gitto, E., Salvo, V., Gargano, G., Balestri, E., Sandri, F., Mescoli, G., Martinelli, S., Ilardi, L., Ciarmoli, E., Di Fabio, S., Maranella, E., Grassia, C., Ausanio, G., Rossi, V., Motta, Alessandro, Tina, L. G., Maiolo, K., Nobile, Stefano, Messner, H., Staffler, Alex, Ferrero, Mattia Francesco, Stasi, I., Pieragostini, L., Mondello, I., Haass, C., Consigli, C., Vedovato, S., Grison, A., Maffei, G., Presta, G., Perniola, R., Vitaliti, M., Re, M. P., De Curtis, M., Cardilli, V., Lago, P., Tormena, F., Orfeo, L., Gizzi, C., Massenzi, L., Gazzolo, D., Strozzi, M. C. M., Bottino, R., Pontiggia, F., Berardi, A., Guidotti, I., Cacace, C., Meli, V., Quartulli, L., Scorrano, A., Casati, A., Grappone, L., Pillow, J. J., Vento G. (ORCID:0000-0002-8132-5127), Pastorino R. (ORCID:0000-0001-5013-0733), Cota F. (ORCID:0000-0002-9009-3997), Tana M., Tirone C., Aurilia C., Lio A., Costa S., D'Andrea V. (ORCID:0000-0002-0980-799X), Giordano L., Fusco F. P., Del Vecchio A., Motta A., Nobile S. (ORCID:0000-0002-5304-1485), Staffler A., and Ferrero F.

Abstract

Background: The importance of lung recruitment before surfactant administration has been shown in animal studies. Well designed trials in preterm infants are absent. We aimed to examine whether the application of a recruitment manoeuvre just before surfactant administration, followed by rapid extubation (intubate-recruit-surfactant-extubate [IN-REC-SUR-E]), decreased the need for mechanical ventilation during the first 72 h of life compared with no recruitment manoeuvre (ie, intubate-surfactant-extubate [IN-SUR-E]). Methods: We did a randomised, unblinded, controlled trial in 35 tertiary neonatal intensive care units in Italy. Spontaneously breathing extremely preterm neonates (24 + 0 to 27 + 6 weeks' gestation) reaching failure criteria for continuous positive airway pressure within the first 24 h of life were randomly assigned (1:1) with a minimisation algorithm to IN-REC-SUR-E or IN-SUR-E using an interactive web-based electronic system, stratified by clinical site and gestational age. The primary outcome was the need for mechanical ventilation in the first 72 h of life. Analyses were done in intention-to-treat and per-protocol populations, with a log-binomial regression model correcting for stratification factors to estimate adjusted relative risk (RR). This study is registered with ClinicalTrials.gov, NCT02482766. Findings: Of 556 infants assessed for eligibility, 218 infants were recruited from Nov 12, 2015, to Sept 23, 2018, and included in the intention-to-treat analysis. The requirement for mechanical ventilation during the first 72 h of life was reduced in the IN-REC-SUR-E group (43 [40%] of 107) compared with the IN-SUR-E group (60 [54%] of 111; adjusted RR 0·75, 95% CI 0·57–0·98; p=0·037), with a number needed to treat of 7·2 (95% CI 3·7–135·0). The addition of the recruitment manoeuvre did not adversely affect the safety outcomes of in-hospital mortality (19 [19%] of 101 in the IN-REC-SUR-E group vs 37 [33%] of 111 in the IN-SUR-E group), pneumothorax (

Published
2020

32. Investigation by top‐down high‐performance liquid chromatography–mass spectrometry of glutathionylation and cysteinylation of salivary S100A9 and cystatin B in preterm newborns.

Author

Boroumand, Mozghan, Manconi, Barbara, Serrao, Simone, Iavarone, Federica, Olianas, Alessandra, Cabras, Tiziana, Contini, Cristina, Pieroni, Luisa, Sanna, Maria Teresa, Vento, Giovanni, Tirone, Chiara, Desiderio, Claudia, Fiorita, Antonella, Faa, Gavino, Messana, Irene, and Castagnola, Massimo

Subjects
CYSTATINS, CYSTEINE proteinase inhibitors, LIQUID chromatography, LIQUID chromatography-mass spectrometry, MASS spectrometry
Abstract

Glutathionylation and cysteinylation can be involved in the protection of critical cysteines from irreversible oxidative damages. S100A9 long and cystatin B, proteins highly represented in the saliva of preterm and at‐term newborns, can undergo these modifications. Levels of S100A9 long and cystatin B and their glutathionylated and cysteinylated derivatives have been determined by a top‐down platform based on high‐performance liquid chromatography–electrospray ionization–mass spectrometry in 100 salivary samples serially collected from 17 preterm newborns with different postconceptional age at birth (178‐226 days) and in 90 salivary samples collected from at‐term newborns and babies. Results showed that: (1) S100A9 long and cystatin B were mainly present as unmodified forms in extremely preterm newborn; (2) the percentage of the S‐thiolated derivatives of both proteins increased with increasing the postconceptional age; (3) the greatest variation occurred up to about 280 days of postconceptional age. Interestingly, differences in the levels of the S‐thiolated derivatives only depended on the postconceptional age and not on whether the infant was born preterm or at‐term. Inadequate levels of cysteine and glutathione might be responsible for the low level of S‐thiolated derivatives measured in preterm newborns. Data are available via ProteomeXchange with identifier PXD025517. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes

Author

Tirone, Chiara, primary, Pezza, Lucilla, additional, Paladini, Angela, additional, Tana, Milena, additional, Aurilia, Claudia, additional, Lio, Alessandra, additional, D'Ippolito, Silvia, additional, Tersigni, Chiara, additional, Posteraro, Brunella, additional, Sanguinetti, Maurizio, additional, Di Simone, Nicoletta, additional, and Vento, Giovanni, additional

Published
2019
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35. Conversion from laparoscopic adjustable gastric banding (LAGB) and laparoscopic sleeve gastrectomy (LSG) to one anastomosis gastric bypass (OAGB): preliminary data from a multicenter retrospective study

Author

Musella, M., Bruni, V., Greco, F., Raffaelli, Marco, Lucchese, Matteo, Susa, A., De Luca, M., Vuolo, G., Manno, E., Vitiello, A., Velotti, N., D'Alessio, R., Facchiano, E., Tirone, Chiara, Iovino, G., Veroux, G., Piazza, L., Raffaelli M. (ORCID:0000-0002-1259-2491), Lucchese M., Tirone A., Musella, M., Bruni, V., Greco, F., Raffaelli, Marco, Lucchese, Matteo, Susa, A., De Luca, M., Vuolo, G., Manno, E., Vitiello, A., Velotti, N., D'Alessio, R., Facchiano, E., Tirone, Chiara, Iovino, G., Veroux, G., Piazza, L., Raffaelli M. (ORCID:0000-0002-1259-2491), Lucchese M., and Tirone A.

Abstract

Background: Laparoscopic sleeve gastrectomy (LSG) is the most commonly performed bariatric procedure, while laparoscopic adjustable gastric banding (LAGB) has been for a decade one of the most popular interventions for weight loss. After LSG and LAGB, some patients may require a second surgery due to weight regain or late complications. One anastomosis gastric bypass (OAGB) is a promising bariatric procedure, which provides effective long-term weight loss and has a favorable effect on type 2 diabetes. Objectives: To retrospectively analyze data from 10 Italian centers on conversion from LAGB and LSG to OAGB. Setting: High-volume centers for bariatric surgery. Methods: Prospectively collected data from 10 high-volume centers were retrospectively reviewed. Body mass index (BMI), percentage of excess BMI loss, reasons for redo, remission from co-morbidities (hypertension, diabetes, gastroesophageal reflux, and dyslipidemia), and major complications were recorded. Results: Three hundred patients were included in the study; 196 patients underwent conversion from LAGB to OAGB and 104 were converted from LSG. BMI was 45.1 ± 7 kg/m2 at the time of first intervention, 41.8 ± 6.3 kg/m2 at redo time, and 30.5 ± 5.5 kg/m2 at last follow-up appointment. Mean percentage of excess BMI loss was 13.2 ± 28.2 at conversion and 73.4 ± 27.5 after OAGB. Remission rates from hypertension, diabetes, gastroesophageal reflux, and dyslipidemia were 40%, 62.5%, 58.7% and 52%, respectively. Mean follow-up was 20.8 (range, 6–156) months and overall complications rate was 8.6%. Conclusion: Our data show that OAGB is a safe and effective revisional procedure after failed restrictive bariatric surgery.

Published
2019

36. Extubation from high-frequency oscillatory ventilation in extremely low birth weight infants: a prospective observational study

Author

Tana, Milena, primary, Lio, Alessandra, additional, Tirone, Chiara, additional, Aurilia, Claudia, additional, Tiberi, Eloisa, additional, Serrao, Francesca, additional, Purcaro, Velia, additional, Corsello, Mirta, additional, Catenazzi, Piero, additional, D’Andrea, Vito, additional, Barone, Giovanni, additional, Ricci, Cinzia, additional, Pastorino, Roberta, additional, and Vento, Giovanni, additional

Published
2018
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37. Nasal high-frequency oscillatory ventilation and CO2 removal: A randomized controlled crossover trial

Author

Bottino, Roberto, primary, Pontiggia, Federica, additional, Ricci, Cinzia, additional, Gambacorta, Alessandro, additional, Paladini, Angela, additional, Chijenas, Vladimiras, additional, Liubsys, Arunas, additional, Navikiene, Jurate, additional, Pliauckiene, Ausrine, additional, Mercadante, Domenica, additional, Colnaghi, Mariarosa, additional, Tana, Milena, additional, Tirone, Chiara, additional, Lio, Alessandra, additional, Aurilia, Claudia, additional, Pastorino, Roberta, additional, Purcaro, Velia, additional, Maffei, Gianfranco, additional, Liberatore, Pio, additional, Consigli, Chiara, additional, Haass, Cristina, additional, Lista, Gianluca, additional, Agosti, Massimo, additional, Mosca, Fabio, additional, and Vento, Giovanni, additional

Published
2018
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38. Nasal high-frequency oscillatory ventilation and CO2 removal: A randomized controlled crossover trial

Author

Bottino, Roberto, Pontiggia, Federica, Ricci, Cinzia, Gambacorta, Alessandro, Paladini, Angela, Chijenas, Vladimira, Liubsys, Aruna, Navikiene, Jurate, Pliauckiene, Ausrine, Mercadante, Domenica, Colnaghi, Mariarosa, Tana, Milena, Tirone, Chiara, Lio, Alessandra, Aurilia, Claudia, Pastorino, Roberta, Purcaro, Velia, Maffei, Gianfranco, Liberatore, Pio, Consigli, Chiara, Haass, Cristina, Lista, Gianluca, Agosti, Massimo, Mosca, Fabio, Vento, Giovanni, Pastorino, Roberta (ORCID:0000-0001-5013-0733), Vento, Giovanni (ORCID:0000-0002-8132-5127), Bottino, Roberto, Pontiggia, Federica, Ricci, Cinzia, Gambacorta, Alessandro, Paladini, Angela, Chijenas, Vladimira, Liubsys, Aruna, Navikiene, Jurate, Pliauckiene, Ausrine, Mercadante, Domenica, Colnaghi, Mariarosa, Tana, Milena, Tirone, Chiara, Lio, Alessandra, Aurilia, Claudia, Pastorino, Roberta, Purcaro, Velia, Maffei, Gianfranco, Liberatore, Pio, Consigli, Chiara, Haass, Cristina, Lista, Gianluca, Agosti, Massimo, Mosca, Fabio, Vento, Giovanni, Pastorino, Roberta (ORCID:0000-0001-5013-0733), and Vento, Giovanni (ORCID:0000-0002-8132-5127)

Abstract

Objective: To compare short-term application of nasal high-frequency oscillatory ventilation (nHFOV) with nasal continuous positive airway pressure (nCPAP). Working Hypothesis: nHFOV improves CO2 removal with respect to nCPAP in preterm infants needing noninvasive respiratory support and persistent oxygen supply after the first 72 h of life. Study Design: Multicenter non-blinded prospective randomized crossover study. Patient Selection: Thirty premature infants from eight tertiary neonatal intensive care units, of mean ± SD 26.4 ± 1.8 weeks of gestational age and 921 ± 177 g of birth weight. Methodology: Infants were randomly allocated in a 1:1 ratio to receive a starting treatment mode of either nCPAP or nHFOV delivered by the ventilator CNO (Medin, Germany), using short binasal prongs of appropriate size. A crossover design with four 1-h treatment periods was used, such that each infant received both treatments twice. The primary outcome was the mean transcutaneous partial pressure of CO2 (TcCO2) value during the 2-h cumulative period of nHFOV compared with the 2-h cumulative period of nCPAP. Results: Significantly lower TcCO2 values were observed during nHFOV compared with nCPAP: 47.5 ± 7.6 versus 49.9 ± 7.2 mmHg, respectively, P = 0.0007. A different TcCO2 behavior was found according to the random sequence: in patients starting on nCPAP, TcCO2 significantly decreased from 50.0 ± 8.0 to 46.6 ± 7.5 mmHg during nHFOV (P = 0.001). In patients starting on nHFOV, TcCO2 slightly increased from 48.5 ± 7.8 to 49.9 ± 6.7 mmHg during nCPAP (P = 0.13). Conclusions: nHFOV delivered through nasal prongs is more effective than nCPAP in improving the elimination of CO2.

Published
2018

40. Fetal Doppler velocimetry and bronchopulmonary dysplasia risk among growth-restricted preterm infants: an observational study

Author

Lio, Alessandra, primary, Rosati, Paolo, additional, Pastorino, Roberta, additional, Cota, Francesco, additional, Tana, Milena, additional, Tirone, Chiara, additional, Aurilia, Claudia, additional, Ricci, Cinzia, additional, Gambacorta, Alessandro, additional, Paladini, Angela, additional, Mappa, Ilenia, additional, Buongiorno, Silvia, additional, Zannoni, Gian Franco, additional, Romagnoli, Costantino, additional, and Vento, Giovanni, additional

Published
2017
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41. Management of pneumothorax in hemodynamically stable preterm infants using high frequency oscillatory ventilation: Report of five cases

Author

Aurilia, Claudia, Ricci, Cinzia, Tana, Milena, Tirone, Chiara, Lio, Alessandra, Gambacorta, Alessandro, Paladini, Angela, Vento, Giovanni, Vento, Giovanni (ORCID:0000-0002-8132-5127), Aurilia, Claudia, Ricci, Cinzia, Tana, Milena, Tirone, Chiara, Lio, Alessandra, Gambacorta, Alessandro, Paladini, Angela, Vento, Giovanni, and Vento, Giovanni (ORCID:0000-0002-8132-5127)

Abstract

Background: Despite an increased use of non-invasive ventilatory strategies and gentle ventilation, pneumothorax remains a common complication in preterm infants. The ventilator management of infants with air leaks remains challenging in terms of both prevention and treatment. Recently the safety and efficacy of expectant management avoiding chest tube drainage to treat large air leak in preterm infants hemodynamically stable has been reported. Case presentation: In the present study, we report five cases of preterm infants with birth weight ≤ 1250 g affected by respiratory distress syndrome and treated with nasal continuous positive airway pressure as first intention. They were intubated for worsening of respiratory distress with increasing oxygen requirement and concomitant increase of respiratory rate and PCO2values due to occurrence of pneumothorax, and they were successfully treated using high-frequency oscillatory ventilation without chest tube insertion. Conclusion: In our experience high-frequency oscillatory ventilation provided a conservative management of a significant pneumothorax in preterm newborns hemodynamically stable and requiring mechanical ventilation. This approach allowed us to avoid the increasing of air leak and the insertion of chest tube drainage and all the subsequent associated risks.

Published
2017

42. Fetal Doppler velocimetry and bronchopulmonary dysplasia risk among growth-restricted preterm infants: An observational study

Author

Lio, Alessandra, Rosati, Paolo, Pastorino, Roberta, Cota, Francesco, Tana, Milena, Tirone, Chiara, Aurilia, Claudia, Ricci, Cinzia, Gambacorta, Alessandro, Paladini, Angela, Mappa, Ilenia, Buongiorno, Silvia, Zannoni, Gian Franco, Romagnoli, Costantino, Vento, Giovanni, Rosati, Paolo (ORCID:0000-0003-0270-7328), Pastorino, Roberta (ORCID:0000-0001-5013-0733), Cota, Francesco (ORCID:0000-0002-9009-3997), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), Vento, Giovanni (ORCID:0000-0002-8132-5127), Lio, Alessandra, Rosati, Paolo, Pastorino, Roberta, Cota, Francesco, Tana, Milena, Tirone, Chiara, Aurilia, Claudia, Ricci, Cinzia, Gambacorta, Alessandro, Paladini, Angela, Mappa, Ilenia, Buongiorno, Silvia, Zannoni, Gian Franco, Romagnoli, Costantino, Vento, Giovanni, Rosati, Paolo (ORCID:0000-0003-0270-7328), Pastorino, Roberta (ORCID:0000-0001-5013-0733), Cota, Francesco (ORCID:0000-0002-9009-3997), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), and Vento, Giovanni (ORCID:0000-0002-8132-5127)

Abstract

Objective To investigate whether fetal growth restriction (FGR) diagnosis, based on pathological prenatal fetal Doppler velocimetry, is associated with bronchopulmonary dysplasia (BPD) independently of being small for gestational age (SGA) per se at birth among very preterm infants. Design Prospective, observational study. FGR was defined as failing fetal growth in utero and fetal Doppler velocimetry abnormalities. Setting Policlinico Universitario Agostino Gemelli, Roma, Italy. Patients Preterm newborns with gestational age ≤30 weeks and birth weight (BW) ≤1250 g. Main outcome measures Bronchopulmonary dysplasia. Results In the study period, 178 newborns were eligible for the study. Thirty-nine infants (22%) were considered fetal growth-restricted infants. Among the 154 survived babies at 36 weeks postmenstrual age, 12 out of 36 (33%) of the FGR group developed BPD versus 8 out of 118 (7%) of the NO-FGR group (p<0.001). BPD rate was sixfold higher among the SGA-FGR infants compared with the SGA-NO-FGR infants. In a multivariable model, FGR was significantly associated with BPD risk (OR 5.1, CI 1.4 to 18.8, p=0.01), independently from BW z-score that still remains a strong risk factor (OR 0.5, CI 0.3 to 0.9, p=0.01). Conclusion Among SGA preterm infants, BPD risk dramatically increases when placenta dysfunction is the surrounding cause of low BW. Antenatal fetal Doppler surveillance could be a useful tool for studying placenta wellness and predicting BPD risk among preterm babies. Further research is needed to better understand how FGR affects lung development.

Published
2017

43. Proteomic characterization of the acid-insoluble fraction of whole saliva from preterm human newborns.

Author

Arba, M, Iavarone, Federica, Vincenzoni, Federica, Manconi, Barbara, Vento, Giovanni, Tirone, Chiara, Cabras, Tiziana, Castagnola, Massimo, Messana, Irene, Sanna, Maria Teresa, Iavarone, F (ORCID:0000-0002-2074-5531), Manconi , Barbara, Vento, Giovanni (ORCID:0000-0002-8132-5127), Cabras , Tiziana, Castagnola, Massimo (ORCID:0000-0002-0959-7259), Messana, Irene (ORCID:0000-0002-1436-6105), Sanna , Maria Teresa, Arba, M, Iavarone, Federica, Vincenzoni, Federica, Manconi, Barbara, Vento, Giovanni, Tirone, Chiara, Cabras, Tiziana, Castagnola, Massimo, Messana, Irene, Sanna, Maria Teresa, Iavarone, F (ORCID:0000-0002-2074-5531), Manconi , Barbara, Vento, Giovanni (ORCID:0000-0002-8132-5127), Cabras , Tiziana, Castagnola, Massimo (ORCID:0000-0002-0959-7259), Messana, Irene (ORCID:0000-0002-1436-6105), and Sanna , Maria Teresa

Abstract

n/a

Published
2016

44. Efficacy of a new technique - INtubate-RECruit-SURfactant-Extubate - 'IN-REC-SUR-E' - in preterm neonates with respiratory distress syndrome: study protocol for a randomized controlled trial.

Author

Vento, Giovanni, Pastorino, Roberta, Boni, L, Cota, Francesco, Carnielli, V, Cools, F, Dani, C, Mosca, F, Pillow, J, Polglase, G, Tagliabue, Roberta Piera, van Kaam, Ah, Ventura, Ml, Tana, Milena, Tirone, Chiara, Aurilia, Claudia, Lio, Alessandra, Ricci, C, Gambacorta, Maria Antonietta, Consigli, C, D'Onofrio, D, Gizzi, C, Massenzi, L, Cardilli, V, Casati, A, Bottino, R, Pontiggia, Federico, Ciarmoli, E, Martinelli, S, Ilardi, L, Colnaghi, M, Matassa, Piero Giuseppe, Vendettuoli, Valentina, Villani, P, Fusco, Francesca Paola, Gazzolo, D, Ricotti, A, Ferrero, F, Stasi, I, Magaldi, R, Maffei, G, Presta, G, Perniola, R, Messina, F, Montesano, G, Poggi, C, Giordano, L, Roma, E, Grassia, C, Ausanio, G, Sandri, F, Mescoli, G, Giura, F, Garani, G, Solinas, A, Lucente, Michele, Nigro, G, Del Vecchio, Angela Maria, Petrillo, F, Orfeo, L, Grappone, L, Quartulli, L, Scorrano, Antonio, Messner, H, Staffler, Alex, Gargano, G, Balestri, E, Nobile, Stefano, Cacace, C, Meli, V, Dallaglio, S, Pasqua, B, Mattia, L, Gitto, E, Vitaliti, M, Re, Mp, Vedovato, S, Grison, A, Berardi, A, Torcetta, F, Guidotti, I, di Fabio, S, Maranella, E, Mondello, I, Visentin, S, Tormena, F., Vento, Giovanni (ORCID:0000-0002-8132-5127), Pastorino, Roberta (ORCID:0000-0001-5013-0733), Cota, Francesco (ORCID:0000-0002-9009-3997), Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), Nobile, S (ORCID:0000-0002-5304-1485), Vento, Giovanni, Pastorino, Roberta, Boni, L, Cota, Francesco, Carnielli, V, Cools, F, Dani, C, Mosca, F, Pillow, J, Polglase, G, Tagliabue, Roberta Piera, van Kaam, Ah, Ventura, Ml, Tana, Milena, Tirone, Chiara, Aurilia, Claudia, Lio, Alessandra, Ricci, C, Gambacorta, Maria Antonietta, Consigli, C, D'Onofrio, D, Gizzi, C, Massenzi, L, Cardilli, V, Casati, A, Bottino, R, Pontiggia, Federico, Ciarmoli, E, Martinelli, S, Ilardi, L, Colnaghi, M, Matassa, Piero Giuseppe, Vendettuoli, Valentina, Villani, P, Fusco, Francesca Paola, Gazzolo, D, Ricotti, A, Ferrero, F, Stasi, I, Magaldi, R, Maffei, G, Presta, G, Perniola, R, Messina, F, Montesano, G, Poggi, C, Giordano, L, Roma, E, Grassia, C, Ausanio, G, Sandri, F, Mescoli, G, Giura, F, Garani, G, Solinas, A, Lucente, Michele, Nigro, G, Del Vecchio, Angela Maria, Petrillo, F, Orfeo, L, Grappone, L, Quartulli, L, Scorrano, Antonio, Messner, H, Staffler, Alex, Gargano, G, Balestri, E, Nobile, Stefano, Cacace, C, Meli, V, Dallaglio, S, Pasqua, B, Mattia, L, Gitto, E, Vitaliti, M, Re, Mp, Vedovato, S, Grison, A, Berardi, A, Torcetta, F, Guidotti, I, di Fabio, S, Maranella, E, Mondello, I, Visentin, S, Tormena, F., Vento, Giovanni (ORCID:0000-0002-8132-5127), Pastorino, Roberta (ORCID:0000-0001-5013-0733), Cota, Francesco (ORCID:0000-0002-9009-3997), Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), and Nobile, S (ORCID:0000-0002-5304-1485)

Abstract

BACKGROUND: Although beneficial in clinical practice, the INtubate-SURfactant-Extubate (IN-SUR-E) method is not successful in all preterm neonates with respiratory distress syndrome, with a reported failure rate ranging from 19 to 69 %. One of the possible mechanisms responsible for the unsuccessful IN-SUR-E method, requiring subsequent re-intubation and mechanical ventilation, is the inability of the preterm lung to achieve and maintain an "optimal" functional residual capacity. The importance of lung recruitment before surfactant administration has been demonstrated in animal studies showing that recruitment leads to a more homogeneous surfactant distribution within the lungs. Therefore, the aim of this study is to compare the application of a recruitment maneuver using the high-frequency oscillatory ventilation (HFOV) modality just before the surfactant administration followed by rapid extubation (INtubate-RECruit-SURfactant-Extubate: IN-REC-SUR-E) with IN-SUR-E alone in spontaneously breathing preterm infants requiring nasal continuous positive airway pressure (nCPAP) as initial respiratory support and reaching pre-defined CPAP failure criteria. METHODS/DESIGN: In this study, 206 spontaneously breathing infants born at 24(+0)-27(+6) weeks' gestation and failing nCPAP during the first 24 h of life, will be randomized to receive an HFOV recruitment maneuver (IN-REC-SUR-E) or no recruitment maneuver (IN-SUR-E) just prior to surfactant administration followed by prompt extubation. The primary outcome is the need for mechanical ventilation within the first 3 days of life. Infants in both groups will be considered to have reached the primary outcome when they are not extubated within 30 min after surfactant administration or when they meet the nCPAP failure criteria after extubation. DISCUSSION: From all available data no definitive evidence exists about a positive effect of recruitment before surfactant instillation, but a rationale exists for testing the following h

Published
2016

45. Efficacy of a new technique – INtubate-RECruit-SURfactant-Extubate – “IN-REC-SUR-E” – in preterm neonates with respiratory distress syndrome: study protocol for a randomized controlled trial

Author

Vento, Giovanni, primary, Pastorino, Roberta, additional, Boni, Luca, additional, Cota, Francesco, additional, Carnielli, Virgilio, additional, Cools, Filip, additional, Dani, Carlo, additional, Mosca, Fabio, additional, Pillow, Jane, additional, Polglase, Graeme, additional, Tagliabue, Paolo, additional, van Kaam, Anton H., additional, Ventura, Maria Luisa, additional, Tana, Milena, additional, Tirone, Chiara, additional, Aurilia, Claudia, additional, Lio, Alessandra, additional, Ricci, Cinzia, additional, Gambacorta, Alessandro, additional, Consigli, Chiara, additional, D’Onofrio, Danila, additional, Gizzi, Camilla, additional, Massenzi, Luca, additional, Cardilli, Viviana, additional, Casati, Alessandra, additional, Bottino, Roberto, additional, Pontiggia, Federica, additional, Ciarmoli, Elena, additional, Martinelli, Stefano, additional, Ilardi, Laura, additional, Colnaghi, Mariarosa, additional, Matassa, Piero Giuseppe, additional, Vendettuoli, Valentina, additional, Villani, Paolo, additional, Fusco, Francesca, additional, Gazzolo, Diego, additional, Ricotti, Alberto, additional, Ferrero, Federica, additional, Stasi, Ilaria, additional, Magaldi, Rosario, additional, Maffei, Gianfranco, additional, Presta, Giuseppe, additional, Perniola, Roberto, additional, Messina, Francesco, additional, Montesano, Giovanna, additional, Poggi, Chiara, additional, Giordano, Lucio, additional, Roma, Enza, additional, Grassia, Carolina, additional, Ausanio, Gaetano, additional, Sandri, Fabrizio, additional, Mescoli, Giovanna, additional, Giura, Francesco, additional, Garani, Giampaolo, additional, Solinas, Agostina, additional, Lucente, Maria, additional, Nigro, Gabriella, additional, Del Vecchio, Antonello, additional, Petrillo, Flavia, additional, Orfeo, Luigi, additional, Grappone, Lidia, additional, Quartulli, Lorenzo, additional, Scorrano, Antonio, additional, Messner, Hubert, additional, Staffler, Alex, additional, Gargano, Giancarlo, additional, Balestri, Eleonora, additional, Nobile, Stefano, additional, Cacace, Caterina, additional, Meli, Valerio, additional, Dallaglio, Sara, additional, Pasqua, Betta, additional, Mattia, Loretta, additional, Gitto, Eloisa, additional, Vitaliti, Marcello, additional, Re, Maria Paola, additional, Vedovato, Stefania, additional, Grison, Alessandra, additional, Berardi, Alberto, additional, Torcetta, Francesco, additional, Guidotti, Isotta, additional, di Fabio, Sandra, additional, Maranella, Eugenia, additional, Mondello, Isabella, additional, Visentin, Stefano, additional, and Tormena, Francesca, additional

Published
2016
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46. Nasal high‐frequency oscillatory ventilation and CO2 removal: A randomized controlled crossover trial.

Author

Bottino, Roberto, Pontiggia, Federica, Ricci, Cinzia, Gambacorta, Alessandro, Paladini, Angela, Chijenas, Vladimiras, Liubsys, Arunas, Navikiene, Jurate, Pliauckiene, Ausrine, Mercadante, Domenica, Colnaghi, Mariarosa, Tana, Milena, Tirone, Chiara, Lio, Alessandra, Aurilia, Claudia, Pastorino, Roberta, Purcaro, Velia, Maffei, Gianfranco, Liberatore, Pio, and Consigli, Chiara

Published
2018
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47. Determination of Lung Volume and Hemodynamic Changes During High-Frequency Ventilation Recruitment in Preterm Neonates With Respiratory Distress Syndrome

Author

Tana, Milena, Polglase, Gr, Cota, Francesco, Tirone, Chiara, Aurilia, Claudia, Lio, Alessandra, Ricci, C, Romagnoli, Costantino, Vento, Giovanni, Cota, Francesco (ORCID:0000-0002-9009-3997), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), Vento, Giovanni (ORCID:0000-0002-8132-5127), Tana, Milena, Polglase, Gr, Cota, Francesco, Tirone, Chiara, Aurilia, Claudia, Lio, Alessandra, Ricci, C, Romagnoli, Costantino, Vento, Giovanni, Cota, Francesco (ORCID:0000-0002-9009-3997), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), and Vento, Giovanni (ORCID:0000-0002-8132-5127)

Abstract

To evaluate the changes in end-expiratory lung volume during an oxygenation-guided stepwise recruitment procedure in elective high-frequency ventilation. We hypothesized that high continuous distending pressure impedes pulmonary blood flow as evidenced by reduced lung volume measurements using respiratory inductive plethysmography. Changes in oxygenation, ventilation, and peripheral perfusion were evaluated as secondary outcomes.

Published
2015

48. Chrono-proteomics of human saliva: variations of the salivary proteome during human development

Author

Messana, Irene, Cabras, Tiziana, Iavarone, Federica, Manconi, Barbara, Huang, Liling, Martelli, Claudia, Olianas, Alessandra, Sanna, Mt, Pisano, Elisabetta, Sanna, M, Arba, M, D'Alessandro, A, Desiderio, Claudia, Vitali, Alberto, Pirolli, Davide, Tirone, Chiara, Lio, Alessandra, Vento, Giovanni, Romagnoli, Costantino, Cordaro, Massimo, Manni, Armando, Gallenzi, Patrizia, Fiorita, Antonella, Scarano, Emanuele, Calo', Lea, Passali, Giulio Cesare, Picciotti, Pasqualina Maria, Paludetti, Gaetano, Fanos, V, Faa, G, Castagnola, Massimo, Messana, Irene (ORCID:0000-0002-1436-6105), Cabras , Tiziana, Iavarone, Federica (ORCID:0000-0002-2074-5531), Manconi , Barbara, Olianas , Alessandra, Pisano , Elisabetta, Pirolli, Davide (ORCID:0000-0003-2303-2577), Vento, Giovanni (ORCID:0000-0002-8132-5127), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), Cordaro, Massimo (ORCID:0000-0002-0797-5172), Manni, Armando (ORCID:0000-0002-7784-1911), Gallenzi, Patrizia (ORCID:0000-0001-9805-4522), Scarano, Emanuele (ORCID:0000-0003-2570-1121), Calo', Lea (ORCID:0000-0003-2671-336X), Passali, Giulio Cesare (ORCID:0000-0002-8176-0962), Picciotti, Pasqualina Maria (ORCID:0000-0002-1502-6508), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Castagnola, Massimo (ORCID:0000-0002-0959-7259), Messana, Irene, Cabras, Tiziana, Iavarone, Federica, Manconi, Barbara, Huang, Liling, Martelli, Claudia, Olianas, Alessandra, Sanna, Mt, Pisano, Elisabetta, Sanna, M, Arba, M, D'Alessandro, A, Desiderio, Claudia, Vitali, Alberto, Pirolli, Davide, Tirone, Chiara, Lio, Alessandra, Vento, Giovanni, Romagnoli, Costantino, Cordaro, Massimo, Manni, Armando, Gallenzi, Patrizia, Fiorita, Antonella, Scarano, Emanuele, Calo', Lea, Passali, Giulio Cesare, Picciotti, Pasqualina Maria, Paludetti, Gaetano, Fanos, V, Faa, G, Castagnola, Massimo, Messana, Irene (ORCID:0000-0002-1436-6105), Cabras , Tiziana, Iavarone, Federica (ORCID:0000-0002-2074-5531), Manconi , Barbara, Olianas , Alessandra, Pisano , Elisabetta, Pirolli, Davide (ORCID:0000-0003-2303-2577), Vento, Giovanni (ORCID:0000-0002-8132-5127), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), Cordaro, Massimo (ORCID:0000-0002-0797-5172), Manni, Armando (ORCID:0000-0002-7784-1911), Gallenzi, Patrizia (ORCID:0000-0001-9805-4522), Scarano, Emanuele (ORCID:0000-0003-2570-1121), Calo', Lea (ORCID:0000-0003-2671-336X), Passali, Giulio Cesare (ORCID:0000-0002-8176-0962), Picciotti, Pasqualina Maria (ORCID:0000-0002-1502-6508), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), and Castagnola, Massimo (ORCID:0000-0002-0959-7259)

Abstract

An important contribution to the variability of any proteome is given by the time dimension that should be carefully considered to define physiological modifications. To this purpose, whole saliva proteome was investigated in a wide age range. Whole saliva was collected from 17 preterm newborns with a postconceptional age at birth of 178-217 days. In these subjects sample collection was performed serially starting immediately after birth and within about 1 year follow-up, gathering a total of 111 specimens. Furthermore, whole saliva was collected from 182 subjects aged between 0 and 17 years and from 23 adults aged between 27 and 57 years. The naturally occurring intact salivary proteome of the 316 samples was analyzed by low- and high-resolution HPLC-ESI-MS platforms. Proteins peculiar of the adults appeared in saliva with different time courses during human development. Acidic proline-rich proteins encoded by PRH2 locus and glycosylated basic proline-rich proteins encoded by PRB3 locus appeared following 180 days of postconceptional age, followed at 7 months (±2 weeks) by histatin 1, statherin, and P-B peptide. The other histatins and acidic proline-rich proteins encoded by PRH1 locus appeared in whole saliva of babies from 1 to 3 weeks after the normal term of delivery, S-type cystatins appeared at 1 year (±3 months), and basic proline-rich proteins appeared at 4 years (±1 year) of age. All of the proteinases involved in the maturation of salivary proteins were more active in preterm than in at-term newborns, on the basis of the truncated forms detected. The activity of the Fam20C kinase, involved in the phosphorylation of various proteins, started around 180 days of postconceptional age, slowly increased reaching values comparable to adults at about 2 years (±6 months) of age. Instead, MAPK14 involved in the phosphorylation of S100A9 was fully active since birth also in preterm newborns.

Published
2015

50. Chrono-Proteomics of Human Saliva: Variations of the Salivary Proteome during Human Development

Author

Messana, Irene, primary, Cabras, Tiziana, additional, Iavarone, Federica, additional, Manconi, Barbara, additional, Huang, Liling, additional, Martelli, Claudia, additional, Olianas, Alessandra, additional, Sanna, Maria Teresa, additional, Pisano, Elisabetta, additional, Sanna, Monica, additional, Arba, Morena, additional, D’Alessandro, Alfredo, additional, Desiderio, Claudia, additional, Vitali, Alberto, additional, Pirolli, Davide, additional, Tirone, Chiara, additional, Lio, Alessandra, additional, Vento, Giovanni, additional, Romagnoli, Costantino, additional, Cordaro, Massimo, additional, Manni, Armando, additional, Gallenzi, Patrizia, additional, Fiorita, Antonella, additional, Scarano, Emanuele, additional, Calò, Lea, additional, Passali, Giulio Cesare, additional, Picciotti, Pasqualina Maria, additional, Paludetti, Gaetano, additional, Fanos, Vassilios, additional, Faa, Gavino, additional, and Castagnola, Massimo, additional

Published
2015
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