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1. NFDI4BIOIMAGE - National Research Data Infrastructure for Microscopy and Bioimage Analysis

Author

Moore, J., Kunis, S., Grüning, B., Blank-Burian, M., Mallm, J.-P., Stöter, T., Zuschratter, W., Figge, M.T., Kreshuk, A., Tischer, C., Haase, R., Zobel, T., Bauer, P., Svensson, C.-M., Gerst, R., Hanne, J., Schmidt, C., Becker, M.M., Bocklitz, T., Bumberger, Jan, Chalopin, C., Chen, J., Czodrowski, P., Dickscheid, T., Fortmann-Grote, C., Huisken, J., Lohmann, J., Schauss, A., Baumann, M., Beretta, C., Burel, J.-M., Heuveline, V., Kuner, R., Landwehr, M., Leibfried, A., Nitschke, R., Mittal, D., von Suchodoletz, H., Valencia-Schneider, M., Zentis, P., Brilhaus, D., Hartley, M., Hülsmann, B., Dunker, Susanne, Keppler, A., Mathur, A., Meesters, C., Möbius, W., Nahnsen, S., Pfander, C., Rehwald, S., Serrano-Solano, B., Vilardell Scholten, L., Vogl, R., Becks, L., Ferrando-May, E., Weidtkamp-Peters, S., Moore, J., Kunis, S., Grüning, B., Blank-Burian, M., Mallm, J.-P., Stöter, T., Zuschratter, W., Figge, M.T., Kreshuk, A., Tischer, C., Haase, R., Zobel, T., Bauer, P., Svensson, C.-M., Gerst, R., Hanne, J., Schmidt, C., Becker, M.M., Bocklitz, T., Bumberger, Jan, Chalopin, C., Chen, J., Czodrowski, P., Dickscheid, T., Fortmann-Grote, C., Huisken, J., Lohmann, J., Schauss, A., Baumann, M., Beretta, C., Burel, J.-M., Heuveline, V., Kuner, R., Landwehr, M., Leibfried, A., Nitschke, R., Mittal, D., von Suchodoletz, H., Valencia-Schneider, M., Zentis, P., Brilhaus, D., Hartley, M., Hülsmann, B., Dunker, Susanne, Keppler, A., Mathur, A., Meesters, C., Möbius, W., Nahnsen, S., Pfander, C., Rehwald, S., Serrano-Solano, B., Vilardell Scholten, L., Vogl, R., Becks, L., Ferrando-May, E., and Weidtkamp-Peters, S.

Abstract

Bioimaging refers to a collection of methods to visualize the internal structures and mechanisms of living organisms. The fundamental tool, the microscope, has enabled seminal discoveries like that of the cell as the smallest unit of life, and continues to expand our understanding of biological processes. Today, we can follow the interaction of single molecules within nanoseconds in a living cell, and the development of complete small organisms like fish and flies over several days starting from the fertilized egg. Each image pixel encodes multiple spatiotemporal and spectral dimensions, compounding the massive volume and complexity of bioimage data. Proper handling of this data is indispensable for analysis and its lack has become a growing hindrance for the many disciplines of the life and biomedical sciences relying on bioimaging. No single domain has the expertise to tackle this bottleneck alone. As a method-specific consortium, NFDI4BIOMAGE seeks to address these issues, enabling bioimaging data to be shared and re-used like they are acquired, i.e., independently of disciplinary boundaries. We will provide solutions for exploiting the full information content of bioimage data and enable new discoveries through sharing and re-analysis. Our RDM strategy is based on a robust needs analysis that derives not only from a community survey but also from over a decade of experience in German BioImaging, the German Society for Microscopy and Image Analysis. It considers the entire lifecycle of bioimaging data, from acquisition to archiving, including analysis and enabling re-use. A foundational element of this strategy is the definition of a common, cloud-compatible, and interoperable digital object that bundles binary images with their descriptive and provenance metadata. With members from plant biology to neuroscience, NFDI4BIOIMAGE will champion the standardization of bioimage data to create a framework that answers discipline-specific needs while ensuring communicati

Published
2024

3. Operational definition of Active and Healthy Ageing (AHA): A conceptual framework

Author

Bousquet, Jean, Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M.E., Rodriguez Mañas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M.L., Samolinski, B., Bonini, S., Brayne, C., Michel, J.P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Ben-Shlomo, Y., Bousquet, P.J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J.M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Andersen Ranberg, K., Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Augé, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G.J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougère, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeande, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O'Neill, M., Pelissier, J.Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H.A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., and Zins, M.

Published
2015
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11. Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? The MeDALL hypothesis

Author

Bousquet, J., Anto, J. M., Wickman, M., Keil, T., Valenta, R., Haahtela, T., Lodrup Carlsen, K., van Hage, M., Akdis, C., Bachert, C., Akdis, M., Auffray, C., Annesi-Maesano, I., Bindslev-Jensen, C., Cambon-Thomsen, A., Carlsen, K. H., Chatzi, L., Forastiere, F., Garcia-Aymerich, J., Gehrig, U., Guerra, S., Heinrich, J., Koppelman, G. H., Kowalski, M. L., Lambrecht, B., Lupinek, C., Maier, D., Melén, E., Momas, I., Palkonen, S., Pinart, M., Postma, D., Siroux, V., Smit, H. A., Sunyer, J., Wright, J., Zuberbier, T., Arshad, S. H., Nadif, R., Thijs, C., Andersson, N., Asarnoj, A., Ballardini, N., Ballereau, S., Bedbrook, A., Benet, M., Bergstrom, A., Brunekreef, B., Burte, E., Calderon, M., De Carlo, G., Demoly, P., Eller, E., Fantini, M. P., Hammad, H., Hohman, C., Just, J., Kerkhof, M., Kogevinas, M., Kull, I., Lau, S., Lemonnier, N., Mommers, M., Nawijn, M., Neubauer, A., Oddie, S., Pellet, J., Pin, I., Porta, D., Saes, Y., Skrindo, I., Tischer, C. G., Torrent, M., and von Hertzen, L.

Published
2015
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12. Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster

Author

Garcia-Aymerich, J., Benet, M., Saeys, Y., Pinart, M., Basagaña, X., Smit, H. A., Siroux, V., Just, J., Momas, I., Rancière, F., Keil, T., Hohmann, C., Lau, S., Wahn, U., Heinrich, J., Tischer, C. G., Fantini, M. P., Lenzi, J., Porta, D., Koppelman, G. H., Postma, D. S., Berdel, D., Koletzko, S., Kerkhof, M., Gehring, U., Wickman, M., Melén, E., Hallberg, J., Bindslev-Jensen, C., Eller, E., Kull, I., Carlsen, Ldrup K. C., Carlsen, K.-H., Lambrecht, B. N., Kogevinas, M., Sunyer, J., Kauffmann, F., Bousquet, J., and Antó, J. M.

Published
2015
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14. Die zwei deutschen Geburtskohorten GINIplus und LISAplus

Author

Heinrich, J., Brüske, I., Schnappinger, M., Standl, M., Flexeder, C., Thiering, E., Tischer, C., Tiesler, C.M.T., Kohlböck, G., Wenig, C.M., Bauer, C.P., Schaaf, B., von Berg, A., Berdel, D., Krämer, U., Cramer, C., Lehmann, I., Herbarth, O., Behrendt, H., Ring, J., Kühnisch, J., and Koletzko, S.

Published
2012
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16. Lifetime prevalence and determinants of hand eczema in an adolescent population in Germany: 15-year follow-up of the LISA cohort study

Author

Wang, J., Tischer, C., Standl, M., Weidinger, S., von Berg, A., Herberth, Gunda, Yew, Y.W., Heinrich, J., Schmitt, J., Apfelbacher, C., Wang, J., Tischer, C., Standl, M., Weidinger, S., von Berg, A., Herberth, Gunda, Yew, Y.W., Heinrich, J., Schmitt, J., and Apfelbacher, C.

Abstract

Background Hand eczema is a common inflammatory skin disorder in both adolescence and adulthood. Objectives We sought to assess the lifetime prevalence of hand eczema and associated exogenous and endogenous risk factors among adolescents in Germany. Methods This was a cross-sectional study embedded into a prospective population-based birth cohort in four regions of Germany, which recruited healthy neonates born between November 1997 and January 1999. We included 1,736 participants who had completed the 15-year follow-up from birth cohort and 84.6% (1,468/1,736) had clearly reported whether they have ever had hand eczema. All the data was based on questionnaires and blood tests (immunoglobulin E). Multivariable logistic regression analysis was used to examine endogenous and exogenous factors in relation to the lifetime prevalence of hand eczema among adolescents. Results 1,468 adolescents (715 girls, 48.7%) were included in the final analysis. The lifetime prevalence of hand eczema among adolescents at the age of 15 was 10.4% (95% confidence interval [CI]: 8.9%–12.1%), with a significantly higher lifetime prevalence among girls than boys (12.7% vs. 8.2%, P = 0.005). Multivariable logistic regression analysis indicated statistically significant associations between the lifetime prevalence of hand eczema and having ever been diagnosed with atopic dermatitis (aOR = 1.8, 95% CI: 1.1–2.8) or having ever had dry skin (aOR=1.9, 95% CI: 1.1–3.1), respectively. No statistically significant independent associations were found between asthma, hay fever, allergy-related clinical symptoms, immunoglobulin E positivity and other exogenous factors in relation to hand eczema. Conclusion Our study fills a research gap on the epidemiological burden of hand eczema among adolescents. One out of ten ever suffered from hand eczema until age 15 years indicating that hand eczema constitutes a significant burden in pediatric populations. The role of atopic dermatitis in hand eczema reinforces

Published
2021

23. Lifetime prevalence and determinants of hand eczema in an adolescent population in Germany: 15‐year follow‐up of the LISA cohort study.

Author

Wang, J., Tischer, C., Standl, M., Weidinger, S., von Berg, A., Herberth, G., Yew, Y.W., Heinrich, J., Schmitt, J., and Apfelbacher, C.

Subjects
*ECZEMA, *CHILD patients, *IMMUNOGLOBULIN E, *COHORT analysis, *LOGISTIC regression analysis, *TEENAGERS
Abstract

Background: Hand eczema is a common inflammatory skin disorder in both adolescence and adulthood. Objectives: We sought to assess the lifetime prevalence of hand eczema and associated exogenous and endogenous risk factors among adolescents in Germany. Methods: This was a cross‐sectional study embedded into a prospective population‐based birth cohort in four regions of Germany, which recruited healthy neonates born between November 1997 and January 1999. We included 1736 participants who had completed the 15‐year follow‐up from birth cohort and 84.6% (1468/1736) had clearly reported whether they have ever had hand eczema. All the data were based on questionnaires and blood tests (immunoglobulin E). Multivariable logistic regression analysis was used to examine endogenous and exogenous factors in relation to the lifetime prevalence of hand eczema among adolescents. Results: One thousand four hundred and sixty‐eight adolescents (715 girls, 48.7%) were included in the final analysis. The lifetime prevalence of hand eczema among adolescents at the age of 15 was 10.4% (95% confidence interval [CI]: 8.9%–12.1%), with a significantly higher lifetime prevalence among girls than boys (12.7% vs. 8.2%, P = 0.005). Multivariable logistic regression analysis indicated statistically significant associations between the lifetime prevalence of hand eczema and having ever been diagnosed with atopic dermatitis (aOR = 1.8, 95% CI: 1.1–2.8) or having ever had dry skin (aOR = 1.9, 95% CI: 1.1–3.1), respectively. No statistically significant independent associations were found between asthma, hay fever, allergy‐related clinical symptoms, immunoglobulin E positivity and other exogenous factors in relation to hand eczema. Conclusion: Our study fills a research gap on the epidemiological burden of hand eczema among adolescents. One out of ten ever suffered from hand eczema until age 15 years indicating that hand eczema constitutes a significant burden in paediatric populations. The role of atopic dermatitis in hand eczema reinforces previous findings. Exogenous risk factors warrant further investigation. Linked Commentary: S. Ljubojevic Hadzavdic & D. Stulhofer Buzina J Eur Acad Dermatol Venereol 2022; 36: 490–491. https://doi.org/10.1111/jdv.17979. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Public health relevance

Author

Tempes, J, Bitzer, EM, Apfelbacher, C, Tischer, C, Tempes, J, Bitzer, EM, Apfelbacher, C, and Tischer, C

Published
2020

25. A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

Author

Corallino S, Malinverno C, Neumann B, Tischer C, Palamidessi A, Frittoli E, Panagiotakopoulou M, Disanza A, Malet-Engra G, Nastaly P, Galli C, Luise C, Bertalot G, Pece S, Di Fiore PP, Gauthier N, Ferrari A, Maiuri P, Scita G, Corallino, S, Malinverno, C, Neumann, B, Tischer, C, Palamidessi, A, Frittoli, E, Panagiotakopoulou, M, Disanza, A, Malet-Engra, G, Nastaly, P, Galli, C, Luise, C, Bertalot, G, Pece, S, Di Fiore, Pp, Gauthier, N, Ferrari, A, Maiuri, P, and Scita, G

Published
2018

28. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

Author

Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. Lodrup, Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M. L., Maier, D., Melen, E., Palkonen, S., Smit, H. A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K. H., Chatzi, L., Coquet, J. M., Curin, M., Demoly, P., Eller, E., Fantini, M. P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., McEachan, R., Makela, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Ranciere, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M. J., Siroux, V., Tischer, C. G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., Xu, C., dIRAS RA-2, Risk Assessment, Clinicum, Department of Dermatology, Allergology and Venereology, Bousquet, J., Anto, J.M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D.S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B.N., Lodrup Carlsen, K.C., Koppelman, G.H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M.L., Maier, D., Melén, E., Palkonen, S., Smit, H.A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K.H., Chatzi, L., Coquet, J.M., Curin, M., Demoly, P., Eller, E., Fantini, M.P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., Mceachan, R., Mäkelä, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Rancière, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M.J., Siroux, V., Tischer, C.G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., and Xu, C.

Subjects
multimorbidity, EUROPEAN INNOVATION PARTNERSHIP, humanos, Immunology, IGE SENSITIZATION, política de salud, Review, rhinitis, Inventions, Unión Europea, Hypersensitivity, Medicine and Health Sciences, Journal Article, Humans, Immunology and Allergy, ATOPIC-DERMATITIS, European Union, biología de sistemas, hipersensibilidad, inmunización, inmunoglobulina E, Asthma, Ige, Multimorbidity, Polysensitization, Rhinitis, BIRTH COHORT, IMMUNE-RESPONSES, Health Policy, Systems Biology, asthma, IgE, polysensitization, CHILDHOOD ASTHMA, invenciones, Immunoglobulin E, Prognosis, INTEGRATED CARE, pronóstico, rhiniti, CHRONIC RESPIRATORY-DISEASES, 3121 General medicine, internal medicine and other clinical medicine, Immunization, IMMUNOLOGICAL REACTIVITY, IMMUNOGLOBULIN-E
Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

Published
2016
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29. Microbial characteristics in homes of asthmatic and non-asthmatic adults in the ECRHS cohort

Author

Valkonen, M., primary, Täubel, M., additional, Pekkanen, J., additional, Tischer, C., additional, Rintala, H., additional, Zock, J.-P., additional, Casas, L., additional, Probst-Hensch, N., additional, Forsberg, B., additional, Holm, M., additional, Janson, C., additional, Pin, I., additional, Gislason, T., additional, Jarvis, D., additional, Heinrich, J., additional, and Hyvärinen, A., additional

Published
2017
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31. Pooling birth cohorts in allergy and asthma: European union-funded initiatives-a MeDALL, CHICOS, ENRIECO, and GALEN joint paper: CHICOS study group ENRIECO study group GA2LEN study group

Author

Bousquet, Jean, Anto, Josep, Sunyer, Jordi, Nieuwenhuijsen, Mark, Vrijheid, Martine, Keil, Thomas, Akdis, M., Auffray, C., Postma, D. S., Valenta, R., Haahtela, T., Cambon-Thomsen, A., Lambrecht, B. N., Akdis, C. A., Annesi-Maesano, I., Arno, A., Bachert, C., Ballester, F., Basagana, X., Baumgartner, U., Bindslev-Jensen, C., Brunekreef, B., Chatzi, L., Eller, E., Forastiere, F., Garcia-Aymerich, J., Guerra, S., Gehring, U., Hammad, H., Heinrich, J., Hohmann, C., Kauffmann, F., Kerkhof, M., Kogevinas, M., Koppelman, G. H., Kowalski, M. L., Kull, I., Lau, S., Lodrup-Carlsen, K. C., Lupinek, C., Maier, D., Makela, M. J., Martinez, F. D., Momas, I., Nawijn, M. C., Neubauer, A., Oddie, S., Palkonen, S., Reitamo, S., Rial-Sebbag, E., Salapatas, M., Siroux, V., Smagghe, D., Smit, H. A., Torrent, M., Toskala, E., van Oosterhout, A. J. M., Varaso, R., von Hertzen, L., Wickman, M., Wijmenga, C., Zuberbier, T., Burney, P. G., Van Cauwenberge, P., Bonini, S., Fokkens, W. J., Kramer, U., Mullol, J., Nizankowska-Mogilnicka, E., Papadopoulos, N., Alm, B., Alm, J., Arshad, S. H., Bravi, F., Canonica, G. W., Custovic, A., Dubakiene, R., Fantini, M. P., Gjomarkaj, M., Halken, S., Host, A., Howarth, P., Kuehni, C., Lotvall, J., Mommers, M., Porta, D., Radon, K., Ring, J., Roberts, G., Schünemann, H. J., Simpson, A., Szczecklik, A., Thijs, C., Todo-Bom, A., Valovirta, E., van Steen, K., Von Berg, A., von Mutius, E., Wahn, U., Wennergren, G., Wijga, A. H., Zock, J. P., Duijts, L., Jaddoe, V., Lawlor, D., Lucas, P., Magnus, P., Merletti, F., Nybo Andersen, A. M., Raat, H., Stoltenberg, C., Casas, M., Bergström, A., Carmichael, A., Chen, C. -M., Cordier, S., Eggesbø, M., Fernández, M. F., Fernández-Somoano, A., Grazuleviciene, R., Karvonen, A. M., Koppen, G., Krämer, U., Kuehni, C. E., Majewska, R., Patelarou, E., Skaalum Petersen, M., Pierik, F. H., Polanska, K., Richiardi, L., Santos, A. C., Slama, R., Sram, R. J., Tischer, C., Toft, G., Trnovec, T., Vandentorren, S., Vardavas, C., Vrijkotte, T. G. M., Wilhelm, M., Bousquet, Jean, Anto, Josep, Sunyer, Jordi, Nieuwenhuijsen, Mark, Vrijheid, Martine, Keil, Thoma, Akdis, M., Auffray, C., Postma, D.S., Valenta, R., Haahtela, T., Cambon-Thomsen, A., Lambrecht, B.N., Akdis, C.A., Annesi-Maesano, I., Arno, A., Bachert, C., Ballester, F., Basagana, X., Baumgartner, U., Bindslev-Jensen, C., Brunekreef, B., Chatzi, L., Eller, E., Forastiere, F., Garcia-Aymerich, J., Guerra, S., Gehring, U., Hammad, H., Heinrich, J., Hohmann, C., Kauffmann, F., Kerkhof, M., Kogevinas, M., Koppelman, G.H., Kowalski, M.L., Kull, I., Lau, S., Lodrup-Carlsen, K.C., Lupinek, C., Maier, D., Makela, M.J., Martinez, F.D., Momas, I., Nawijn, M.C., Neubauer, A., Oddie, S., Palkonen, S., Reitamo, S., Rial-Sebbag, E., Salapatas, M., Siroux, V., Smagghe, D., Smit, H.A., Torrent, M., Toskala, E., van Oosterhout, A.J.M., Varaso, R., von Hertzen, L., Wickman, M., Wijmenga, C., Zuberbier, T., Burney, P.G., Van Cauwenberge, P., Bonini, S., Fokkens, W.J., Kramer, U., Mullol, J., Nizankowska-Mogilnicka, E., Papadopoulos, N., Alm, B., Alm, J., Arshad, S.H., Bravi, F., Canonica, G.W., Custovic, A., Dubakiene, R., Fantini, M.P., Gjomarkaj, M., Halken, S., Host, A., Howarth, P., Kuehni, C., Lotvall, J., Mommers, M., Porta, D., Radon, K., Ring, J., Roberts, G., Schünemann, H.J., Simpson, A., Szczecklik, A., Thijs, C., Todo-Bom, A., Valovirta, E., van Steen, K., Von Berg, A., von Mutius, E., Wahn, U., Wennergren, G., Wijga, A.H., Zock, J.P., Duijts, L., Jaddoe, V., Lawlor, D., Lucas, P., Magnus, P., Merletti, F., Nybo Andersen, A.M., Raat, H., Stoltenberg, C., Casas, M., Bergström, A., Carmichael, A., Chen, C.-M., Cordier, S., Eggesbø, M., Fernández, M.F., Fernández-Somoano, A., Grazuleviciene, R., Karvonen, A.M., Koppen, G., Krämer, U., Kuehni, C.E., Majewska, R., Patelarou, E., Skaalum Petersen, M., Pierik, F.H., Polanska, K., Richiardi, L., Santos, A.C., Slama, R., Sram, R.J., Tischer, C., Toft, G., Trnovec, T., Vandentorren, S., Vardavas, C., Vrijkotte, T.G.M., and Wilhelm, M.

Subjects
Allergy, Risk Factor, Immunology, CHICOS, Longitudinal Studie, Environmental Exposure, Asthma, Europe, MeDALL, ENRIECO, Hypersensitivity, Multicenter Studies as Topic, Immunology and Allergy, European Union, Cohort Studie, Birth cohort, Human
Abstract

Long-term birth cohort studies are essential to understanding the life course and childhood predictors of allergy and the complex interplay between genes and the environment (including lifestyle and socioeconomic determinants). Over 100 cohorts focusing on asthma and allergy have been initiated in the world over the past 30 years. Since 2004, several research initiatives funded under the EU Framework Program for Research and Technological Development FP6-FP7 have attempted to identify, compare, and evaluate pooling data from existing European birth cohorts (GA2LEN: Global Allergy and European Network, FP6; ENRIECO: Environmental Health Risks in European Birth Cohorts, FP7; CHICOS: Developing a Child Cohort Research Strategy for Europe, FP7; MeDALL: Mechanisms of the Development of ALLergy, FP7). However, there is a general lack of knowledge about these initiatives and their potentials. The aim of this paper is to review current and past EU-funded projects in order to make a summary of their goals and achievements and to suggest future research needs of these European birth cohort networks. © 2012 S. Karger AG, Basel.

Published
2013

32. Indoor microbiome and asthma : a case-control study within ECRHS

Author

Pekkanen, J., Valkonen, M., Taubel, M., Leppanen, H., Karkkainen, P., Rintala, H., Zock, J., Casas, L., Tischer, C., Probst-Hensch, N., Forsberg, B., Holm, M., Jahnson, Christer, Pin, I, Gislason, T., Jarvis, D., Heinrich, J., Hyvarinen, A., Pekkanen, J., Valkonen, M., Taubel, M., Leppanen, H., Karkkainen, P., Rintala, H., Zock, J., Casas, L., Tischer, C., Probst-Hensch, N., Forsberg, B., Holm, M., Jahnson, Christer, Pin, I, Gislason, T., Jarvis, D., Heinrich, J., and Hyvarinen, A.

Published
2017

33. Building dampness and mold in European homes in relation to climate, building characteristics and socio-economic status : The European Community Respiratory Health Survey ECRHS II

Author

Norbäck, Dan, Zock, J-P, Plana, E, Heinrich, J, Tischer, C, Jacobsen Bertelsen, R, Sunyer, J, Künzli, N, Villani, S, Olivieri, M, Verlato, G, Soon, A, Schlünssen, V, Gunnbjörnsdottir, M I, Jarvis, D, Norbäck, Dan, Zock, J-P, Plana, E, Heinrich, J, Tischer, C, Jacobsen Bertelsen, R, Sunyer, J, Künzli, N, Villani, S, Olivieri, M, Verlato, G, Soon, A, Schlünssen, V, Gunnbjörnsdottir, M I, and Jarvis, D

Abstract

We studied dampness and mold in homes in relation to climate, building characteristics and socio-economic status (SES) across Europe, for 7127 homes in 22 centers. A subsample of 3118 homes was inspected. Multilevel analysis was applied, including age, gender, center, SES, climate, and building factors. Self-reported water damage (10%), damp spots (21%), and mold (16%) in past year were similar as observed data (19% dampness and 14% mold). Ambient temperature was associated with self-reported water damage (OR=1.63 per 10°C; 95% CI 1.02-2.63), damp spots (OR=2.95; 95% CI 1.98-4.39), and mold (OR=2.28; 95% CI 1.04-4.67). Precipitation was associated with water damage (OR=1.12 per 100 mm; 95% CI 1.02-1.23) and damp spots (OR=1.11; 95% CI 1.02-1.20). Ambient relative air humidity was not associated with indoor dampness and mold. Older buildings had more dampness and mold (P<.001). Manual workers reported less water damage (OR=0.69; 95% CI 0.53-0.89) but more mold (OR=1.27; 95% CI 1.03-1.55) as compared to managerial/professional workers. There were correlations between reported and observed data at center level (Spearman rho 0.61 for dampness and 0.73 for mold). In conclusion, high ambient temperature and precipitation and high building age can be risk factors for dampness and mold in homes in Europe.

Published
2017
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34. Lifelong Residential Exposure to Green Space and Attention

Author

Dadvand, P. (Payam), Tischer, C. (Christina), Estarlich, M. (Marisa), Llop, S. (Sabrina), Dalmau-Bueno, A. (Albert), López-Vicente, M. (Mònica), Valentín, A. (Antònia), de Keijzer, C. (Carmen), Fernández-Somoano, A. (Ana), Lertxundi, N. (Nerea), Rodriguez-Dehli, C. (Cristina), Gascon, M. (Mireia), Guxens Junyent, M. (Mònica), Zugna, D. (Daniela), Basagaña, X. (Xavier), Nieuwenhuijsen, M. (Mark), Ibarluzea, J.M. (Jesús), Ballester, F. (Ferran), Sunyer, J. (Jordi), Dadvand, P. (Payam), Tischer, C. (Christina), Estarlich, M. (Marisa), Llop, S. (Sabrina), Dalmau-Bueno, A. (Albert), López-Vicente, M. (Mònica), Valentín, A. (Antònia), de Keijzer, C. (Carmen), Fernández-Somoano, A. (Ana), Lertxundi, N. (Nerea), Rodriguez-Dehli, C. (Cristina), Gascon, M. (Mireia), Guxens Junyent, M. (Mònica), Zugna, D. (Daniela), Basagaña, X. (Xavier), Nieuwenhuijsen, M. (Mark), Ibarluzea, J.M. (Jesús), Ballester, F. (Ferran), and Sunyer, J. (Jordi)

Abstract

BACKGROUND: Natural environments, including green spaces, may have beneficial impacts on brain development. However, longitudinal evidence of an association between long-term exposure to green spaces and cognitive development (including attention) in children is limited. OBJECTIVES: We evaluated the association between lifelong residential exposure to green space and attention during preschool and early primary school years. METHODS: This longitudinal study was based on data from two well-established population-based birth cohorts in Spain. We assessed lifelong exposure to residential surrounding greenness and tree cover as the average of satellite-based normalized difference vegetation index and vegetation continuous fields, respectively, surrounding the child's residential addresses at birth, 4-5 y, and 7 y. Attention was characterized using two computer-based tests: Conners' Kiddie Continuous Performance Test (K-CPT) at 4-5 y (n=888) and Attentional Network Task (ANT) at 7 y (n=987). We used adjusted mixed effects models with cohort random effects to estimate associations between exposure to greenness and attention at ages 4-5 and 7 y. RESULTS: Higher lifelong residential surrounding greenness was associated with fewer K-CPT omission errors and lower K-CPT hit reaction time-standard error (HRT-SE) at 4-5 y and lower ANT HRT-SE at 7 y, consistent with better attention. This exposure was not associated with K-CPT commission errors or with ANT omission or commission errors. Associations with residential surrounding tree cover also were close to the null, or were negative (for ANT HRT-SE) but not statistically significant. CONCLUSION: Exposure to residential surrounding greenness was associated with better scores on tests of attention at 4-5 y and 7 y of age in our longitudinal cohort. https://doi.org/10.1289/EHP694.

Published
2017
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35. Lifelong Residential Exposure to Green Space and Attention: A Population-based Prospective Study

Author

Dadvand, P, Tischer, C, Estarlich, M, Llop, S, Dalmau-Bueno, A, Lopez-Vicente, M, Valentin, A, de Keijzer, C, Fernandez-Somoano, A, Lertxundi, N, Rodriguez-Dehli, C, Gascon, M, Guxens Junyent, Monica, Zugna, D, Basagana, X, Nieuwenhuijsen, MJ, Ibarluzea, J, Ballester, F, Sunyer, J, Dadvand, P, Tischer, C, Estarlich, M, Llop, S, Dalmau-Bueno, A, Lopez-Vicente, M, Valentin, A, de Keijzer, C, Fernandez-Somoano, A, Lertxundi, N, Rodriguez-Dehli, C, Gascon, M, Guxens Junyent, Monica, Zugna, D, Basagana, X, Nieuwenhuijsen, MJ, Ibarluzea, J, Ballester, F, and Sunyer, J

Published
2017

36. European birth cohorts for environmental health research

Author

Vrijheid, M., Casas, M., Bergström, A., Carmichael, A., Cordier, S., Eggesbø, M., Eller, E., Fantini, M.P., Fernández, M.F., Fernández-Somoano, A., Gehring, U., Grazuleviciene, R., Hohmann, C., Karvonen, A.M., Keil, T., Kogevinas, M., Koppen, G., Krämer, U., Kuehni, C.E., Magnus, P., Majewska, R., Andersen, A., Patelarou, E., Petersen, M., Pierik, F.H., Polanska, K., Porta, D., Richiardi, L., Santos, A, Slama, R., Sram, R.J., Thijs, C., Tischer, C., Toft, G., Trnovec, T., Vandentorren, S., Vrijkotte, T.G.M., Wilhelm, M., Wright, J., Nieuwenhuijsen, M., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Vrijheid M., Casas M., Bergström A., Carmichael A., Cordier S., Eggesbø M., Eller E., Fantini M.P., Fernández M.F., Fernández-Somoano A., Gehring U., Grazuleviciene R., Hohmann C., Karvonen A.M., Keil T., Kogevinas M., Koppen G., Krämer U., Kuehni C., Magnus P., Majewska R., Andersen A.M., Patelarou E., Petersen M.S., Pierik F.H., Polanska K., Porta D., Richiardi L., Santos A.C., Slama R., Sram R.J., Thijs C., Tischer C., Toft G., Trnovec T., Vandentorren S., Vrijkotte T.G., Wilhelm M., Wright J., Nieuwenhuijsen M., Le Corre, Morgane, IMIM-Hospital del Mar, Generalitat de Catalunya, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Spanish Consortium for Research on Epidemiology and Public Health, CIBER de Epidemiología y Salud Pública (CIBERESP), Institute of Environmental Medicine, Karolinska Institutet [Stockholm]-Sachs' Children's Hospital, School of Social and Community Medicine, University of Bristol [Bristol], Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Division of Epidemiology, Norwegian Institute of Public Health [Oslo] (NIPH), Department of Dermatology and Allergy Centre, Odense University Hospital, Department of Public Health, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Risk Assessment Sciences Institute, Utrecht University [Utrecht], Vytautas Magnus University - Vytauto Didziojo Universitetas (VDU), Institute of Social Medicine, Epidemiology and Health Economics-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Environmental Health, National Institute for Health and Welfare [Helsinki], Environmental Risk and Health Unit, Flemish Institute for Technological Research (VITO), IUF, Leibniz Research Institute for Environmental Medicine (IUF), Institute of Social and Preventive Medicine (ISPM), University of Bern, Epidemiology and Preventive Medicine, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Section of Social Medicine, Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH)-Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Department of Social Medicine, University of Crete [Heraklion] (UOC)-Medical School, Department of Occupational Medicine and Public Health, The Faroese Hospital System (Landssjúkrahúsið) (LS), Department of Urban Environment, The Netherlands Organisation for Applied Scientific Research (TNO), Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Department of Epidemiology, Regional Health Service - Lazio, Cancer Epidemiology Unit, Université de Turin-CPO-Piemonte, Department of Hygiene and Epidemiology, Universidade do Porto = University of Porto, Environmental Epidemiology Applied to Reproduction and Respiratory Health, Epidémiologie pronostique des cancers et affections graves, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute of Experimental Medicine AS CR, Maastricht University [Maastricht]-School for Public Health and Primary Care (CAPHRI), Institute of Epidemiology [Neuherberg] (EPI), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Department of Occupational Medicine, Aarhus University Hospital, Slovak Medical University of Bratislava (SMU), Institut de Veille Sanitaire (INVS), Academic Medical Centre, Hygiene, Social and Environmental Medicine, Ruhr University Bochum (RUB), Bradford Institute for Health Research, Environmental Health Risks in European Birth Cohorts (ENRIECO), the European Union's Seventh Framework Programme (Theme 6, Environment, including climate change), grant agreement 226285., Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Epidemiology and Health Economics, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)-Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Universidade do Porto-University of Porto Medical School and Institute of Public Health, and Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK (BIHR)

Subjects
Passive smoking, Databases, Factual, Health, Toxicology and Mutagenesis, Review, 010501 environmental sciences, Medi ambient -- Anàlisi d'impacte, medicine.disease_cause, 01 natural sciences, birth cohorts, child health, environmental exposures, Europe, review, Cohort Studies, MESH: Pregnancy, 0302 clinical medicine, Salut ambiental, Pregnancy, MESH: Child, 030212 general & internal medicine, MESH: Maternal Exposure, Child, MESH: Cohort Studies, Child health, Birth cohorts, MESH: Infant, Newborn, Environmental exposure, MESH: Infant, 3. Good health, MESH: Internet, Maternal Exposure, UES - Urban Environment & Safety, Child, Preschool, Female, EELS - Earth, Environmental and Life Sciences, Environmental Health, Cohort study, Earth & Environment, MESH: Environmental Exposure, Energy / Geological Survey Netherlands, MEDLINE, 610 Medicine & health, Environment, 03 medical and health sciences, Environmental health, medicine, Humans, Infants -- Salut i higiene, 0105 earth and related environmental sciences, Asthma, Internet, MESH: Humans, business.industry, MESH: Child, Preschool, Environmental exposures, Public Health, Environmental and Occupational Health, Infant, Newborn, Infant, Environmental Exposure, medicine.disease, MESH: Databases, Factual, Obesity, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Causal inference, MESH: Environmental Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, business, MESH: Female
Abstract

This work was supported by Environmental Health Risks in European Birth Cohorts (ENRIECO), a project conducted within the European Union’s Seventh Framework Programme (Theme 6, Environment, including climate change), grant agreement 226285., Vrijheid, M., Casas, M., Bergström, A., Carmichael, A., Cordier, S., Eggesbø, M., Eller, E., Fantini, M.P., Fernández, M.F., Fernández-Somoano, A., Gehring, U., Grazuleviciene, R., Hohmann, C., Karvonen, A.M., Keil, T., Kogevinas, M., Koppen, G., Krämer, U., Kuehni, C.E., Magnus, P., Majewska, R., Andersen, A.-M.N., Patelarou, E., Petersen, M.S., Pierik, F.H., Polanska, K., Porta, D., Richiardi, L., Santos, A.C., Slama, R., Sram, R.J., Thijs, C., Tischer, C., Toft, G., Trnovec, T., Vandentorren, S., Vrijkotte, T.G.M., Wilhelm, M., Wright, J., Nieuwenhuijsen, M.

Published
2012
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37. Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster

Author

Garcia-Aymerich, J. Benet, M. Saeys, Y. Pinart, M. and Basagana, X. Smit, H. A. Siroux, V. Just, J. Momas, I. and Ranciere, F. Keil, T. Hohmann, C. Lau, S. Wahn, U. and Heinrich, J. Tischer, C. G. Fantini, M. P. Lenzi, J. and Porta, D. Koppelman, G. H. Postma, D. S. Berdel, D. and Koletzko, S. Kerkhof, M. Gehring, U. Wickman, M. Melen, E. Hallberg, J. Bindslev-Jensen, C. Eller, E. Kull, I. and Carlsen, K. C. Lodrup Carlsen, K. -H. Lambrecht, B. N. and Kogevinas, M. Sunyer, J. Kauffmann, F. Bousquet, J. and Anto, J. M.

Abstract

BackgroundAsthma, rhinitis and eczema often co-occur in children, but their interrelationships at the population level have been poorly addressed. We assessed co-occurrence of childhood asthma, rhinitis and eczema using unsupervised statistical techniques. MethodsWe included 17209 children at 4years and 14585 at 8years from seven European population-based birth cohorts (MeDALL project). At each age period, children were grouped, using partitioning cluster analysis, according to the distribution of 23 variables covering symptoms ever’ and in the last 12months’, doctor diagnosis, age of onset and treatments of asthma, rhinitis and eczema; immunoglobulin E sensitization; weight; and height. We tested the sensitivity of our estimates to subject and variable selections, and to different statistical approaches, including latent class analysis and self-organizing maps. ResultsTwo groups were identified as the optimal way to cluster the data at both age periods and in all sensitivity analyses. The first (reference) group at 4 and 8years (including 70% and 79% of children, respectively) was characterized by a low prevalence of symptoms and sensitization, whereas the second (symptomatic) group exhibited more frequent symptoms and sensitization. Ninety-nine percentage of children with comorbidities (co-occurrence of asthma, rhinitis and/or eczema) were included in the symptomatic group at both ages. The children’s characteristics in both groups were consistent in all sensitivity analyses. ConclusionAt 4 and 8years, at the population level, asthma, rhinitis and eczema can be classified together as an allergic comorbidity cluster. Future research including time-repeated assessments and biological data will help understanding the interrelationships between these diseases.

Published
2015

38. The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children

Author

Vardavas, C. I., Hohmann, C., Patelarou, E., Martinez, D., Henderson, A. J., Granell, R., Sunyer, J., Torrent, M., Fantini, M. P., Gori, D., Annesi-Maesano, I., Slama, R., Duijts, L., de Jongste, J. C., Aurrekoetxea, J. J., Basterrechea, M., Morales, E., Ballester, F., Murcia, M., Thijs, C., Mommers, M., Kuehni, C. E., Gaillard, E. A., Tischer, C., Heinrich, J., Pizzi, C., Zugna, D., Gehring, U., Wijga, Alet H., Chatzi, L., Vassilaki, M., Bergstrom, A., Eller, E., Lau, S., Keil, T., Nieuwenhuijsen, M., Kogevinas, M., Vardavas, C. I., Hohmann, C., Patelarou, E., Martinez, D., Henderson, A. J., Granell, R., Sunyer, J., Torrent, M., Fantini, M. P., Gori, D., Annesi-Maesano, I., Slama, R., Duijts, L., de Jongste, J. C., Aurrekoetxea, J. J., Basterrechea, M., Morales, E., Ballester, F., Murcia, M., Thijs, C., Mommers, M., Kuehni, C. E., Gaillard, E. A., Tischer, C., Heinrich, J., Pizzi, C., Zugna, D., Gehring, U., Wijga, Alet H., Chatzi, L., Vassilaki, M., Bergstrom, A., Eller, E., Lau, S., Keil, T., Nieuwenhuijsen, M., and Kogevinas, M.

Abstract

Maternal smoking during pregnancy increases childhood asthma risk, but health effects in children of nonsmoking mothers passively exposed to tobacco smoke during pregnancy are unclear. We examined the association of maternal passive smoking during pregnancy and wheeze in children aged <= 2 years. Individual data of 27 993 mother-child pairs from 15 European birth cohorts were combined in pooled analyses taking into consideration potential confounders. Children with maternal exposure to passive smoking during pregnancy and no other smoking exposure were more likely to develop wheeze up to the age of 2 years (OR 1.11, 95% CI 1.03-1.20) compared with unexposed children. Risk of wheeze was further increased by children's postnatal passive smoke exposure in addition to their mothers' passive exposure during pregnancy (OR 1.29, 95% CI 1.19-1.40) and highest in children with both sources of passive exposure and mothers who smoked actively during pregnancy (OR 1.73, 95% CI 1.59-1.88). Risk of wheeze associated with tobacco smoke exposure was higher in children with an allergic versus nonallergic family history. Maternal passive smoking exposure during pregnancy is an independent risk factor for wheeze in children up to the age of 2 years. Pregnant females should avoid active and passive exposure to tobacco smoke for the benefit of their children's health.

Published
2016

39. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

Author

Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, Xu, C, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, and Xu, C

Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

Published
2016

40. Paving the way of systems biology and precision medicine in allergic diseases

Author

University of Helsinki, Clinicum, University of Helsinki, Departments of Dermatology, Allergology and Venereology, Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. Lodrup, Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M. L., Maier, D., Melen, E., Palkonen, S., Smit, H. A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K. H., Chatzi, L., Coquet, J. M., Curin, M., Demoly, P., Eller, E., Fantini, M. P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., McEachan, R., Mäkelä, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Ranciere, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M. J., Siroux, V., Tischer, C. G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., Xu, C., University of Helsinki, Clinicum, University of Helsinki, Departments of Dermatology, Allergology and Venereology, Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. Lodrup, Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M. L., Maier, D., Melen, E., Palkonen, S., Smit, H. A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K. H., Chatzi, L., Coquet, J. M., Curin, M., Demoly, P., Eller, E., Fantini, M. P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., McEachan, R., Mäkelä, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Ranciere, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M. J., Siroux, V., Tischer, C. G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., and Xu, C.

Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

Published
2016

41. The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children

Author

LS IRAS EEPI ME (Milieu epidemiologie), Geneeskunde van gezelschapsdieren, dIRAS RA-2, Vardavas, C. I., Hohmann, C., Patelarou, E., Martinez, D., Henderson, A. J., Granell, R., Sunyer, J., Torrent, M., Fantini, M. P., Gori, D., Annesi-Maesano, I., Slama, R., Duijts, L., de Jongste, J. C., Aurrekoetxea, J. J., Basterrechea, M., Morales, E., Ballester, F., Murcia, M., Thijs, C., Mommers, M., Kuehni, C. E., Gaillard, E. A., Tischer, C., Heinrich, J., Pizzi, C., Zugna, D., Gehring, U., Wijga, Alet H., Chatzi, L., Vassilaki, M., Bergstrom, A., Eller, E., Lau, S., Keil, T., Nieuwenhuijsen, M., Kogevinas, M., LS IRAS EEPI ME (Milieu epidemiologie), Geneeskunde van gezelschapsdieren, dIRAS RA-2, Vardavas, C. I., Hohmann, C., Patelarou, E., Martinez, D., Henderson, A. J., Granell, R., Sunyer, J., Torrent, M., Fantini, M. P., Gori, D., Annesi-Maesano, I., Slama, R., Duijts, L., de Jongste, J. C., Aurrekoetxea, J. J., Basterrechea, M., Morales, E., Ballester, F., Murcia, M., Thijs, C., Mommers, M., Kuehni, C. E., Gaillard, E. A., Tischer, C., Heinrich, J., Pizzi, C., Zugna, D., Gehring, U., Wijga, Alet H., Chatzi, L., Vassilaki, M., Bergstrom, A., Eller, E., Lau, S., Keil, T., Nieuwenhuijsen, M., and Kogevinas, M.

Published
2016

42. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

Author

dIRAS RA-2, Risk Assessment, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, Xu, C, dIRAS RA-2, Risk Assessment, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, and Xu, C

Published
2016

43. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

Author

Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Epi Infectieziekten Team 3, Infection & Immunity, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, Xu, C, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Epi Infectieziekten Team 3, Infection & Immunity, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, and Xu, C

Published
2016

44. Paving the way of systems biology and precision medicine in allergic diseases: the Me DALL success story

Author

Bousquet, J., primary, Anto, J. M., additional, Akdis, M., additional, Auffray, C., additional, Keil, T., additional, Momas, I., additional, Postma, D.S., additional, Valenta, R., additional, Wickman, M., additional, Cambon‐Thomsen, A., additional, Haahtela, T., additional, Lambrecht, B. N., additional, Lodrup Carlsen, K. C., additional, Koppelman, G. H., additional, Sunyer, J., additional, Zuberbier, T., additional, Annesi‐Maesano, I., additional, Arno, A., additional, Bindslev‐Jensen, C., additional, De Carlo, G., additional, Forastiere, F., additional, Heinrich, J., additional, Kowalski, M. L., additional, Maier, D., additional, Melén, E., additional, Palkonen, S., additional, Smit, H. A., additional, Standl, M., additional, Wright, J., additional, Asarnoj, A., additional, Benet, M., additional, Ballardini, N., additional, Garcia‐Aymerich, J., additional, Gehring, U., additional, Guerra, S., additional, Hohman, C., additional, Kull, I., additional, Lupinek, C., additional, Pinart, M., additional, Skrindo, I., additional, Westman, M., additional, Smagghe, D., additional, Akdis, C., additional, Albang, R., additional, Anastasova, V., additional, Anderson, N., additional, Bachert, C., additional, Ballereau, S., additional, Ballester, F., additional, Basagana, X., additional, Bedbrook, A., additional, Bergstrom, A., additional, Berg, A., additional, Brunekreef, B., additional, Burte, E., additional, Carlsen, K. H., additional, Chatzi, L., additional, Coquet, J. M., additional, Curin, M., additional, Demoly, P., additional, Eller, E., additional, Fantini, M. P., additional, Gerhard, B., additional, Hammad, H., additional, Hertzen, L., additional, Hovland, V., additional, Jacquemin, B., additional, Just, J., additional, Keller, T., additional, Kerkhof, M., additional, Kiss, R., additional, Kogevinas, M., additional, Koletzko, S., additional, Lau, S., additional, Lehmann, I., additional, Lemonnier, N., additional, McEachan, R., additional, Mäkelä, M., additional, Mestres, J., additional, Minina, E., additional, Mowinckel, P., additional, Nadif, R., additional, Nawijn, M., additional, Oddie, S., additional, Pellet, J., additional, Pin, I., additional, Porta, D., additional, Rancière, F., additional, Rial‐Sebbag, A., additional, Saeys, Y., additional, Schuijs, M. J., additional, Siroux, V., additional, Tischer, C. G., additional, Torrent, M., additional, Varraso, R., additional, De Vocht, J., additional, Wenger, K., additional, Wieser, S., additional, and Xu, C., additional

Published
2016
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45. The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children

Author

Vardavas, C.I., primary, Hohmann, C., additional, Patelarou, E., additional, Martinez, D., additional, Henderson, A.J., additional, Granell, R., additional, Sunyer, J., additional, Torrent, M., additional, Fantini, M.P., additional, Gori, D., additional, Annesi-Maesano, I., additional, Slama, R., additional, Duijts, L., additional, de Jongste, J.C., additional, Aurrekoetxea, J.J., additional, Basterrechea, M., additional, Morales, E., additional, Ballester, F., additional, Murcia, M., additional, Thijs, C., additional, Mommers, M., additional, Kuehni, C.E., additional, Gaillard, E.A., additional, Tischer, C., additional, Heinrich, J., additional, Pizzi, C., additional, Zugna, D., additional, Gehring, U., additional, Wijga, A., additional, Chatzi, L., additional, Vassilaki, M., additional, Bergström, A., additional, Eller, E., additional, Lau, S., additional, Keil, T., additional, Nieuwenhuijsen, M., additional, and Kogevinas, M., additional

Published
2016
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47. Maternal smoking in pregnancy and asthma in preschool children: a pooled analysis of eight birth cohorts

Author

Neuman, A., Hohmann, C., Pershagen, G., Eller, E., Kjaer, H.F., Gehring, U., Granell, R., Henderson, J., Lau, S., Nieuwenhuijsen, M., Sunyer, J., Tischer, C., Torrent, M., Wahn, U., Wijga, A.H., Wickman, M., Keil, T., Bergström, A., Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS

Abstract

Rationale: Although epidemiological studies suggest that exposure to maternal smoking during fetal and early life increases the risk of childhood wheezing and asthma, previous studies were not able to differentiate the effects of prenatal from postnatal exposure. Objectives: To assess the effect of exposure to maternal smoking only during pregnancy on wheeze and asthma among preschool-age children. Methods: A pooled analysis was performed based on individual participant data from eight European birth cohorts. Cohort-specific effects of maternal smoking during pregnancy, but not during the first year, on wheeze and asthma at 4 to 6 years of age were estimated using logistic regression and then combined using a random effects model. Adjustments were made for sex, parental education, parental asthma, birth weight, and siblings. Measurements and Main Results: Among the 21,600 children included in the analysis, 735 children (3.4%) were exposed to maternal smoking exclusively during pregnancy but not in the first year after birth. In the pooled analysis, maternal smoking only during pregnancy was associated with wheeze and asthma at 4 to 6 years of age, with adjusted odds ratios of 1.39 (95% confidence interval, 1.08-1.77) and 1.65 (95% confidence interval, 1.18-2.31), respectively. The likelihood to develop wheeze and asthma increased statistically significantly in a linear dose-dependent manner in relation to maternal daily cigarette consumption during the first trimester of pregnancy. Conclusions: Maternal smoking during pregnancy appears to increase the risk of wheeze and asthma among children who are not exposed to maternal smoking after birth.

Published
2012

48. Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling?: The MeDALL hypothesis

Author

Bousquet, J, Anto, J M, Wickman, M, Keil, T, Valenta, R, Haahtela, T, Lodrup Carlsen, K, van Hage, M, Akdis, C, Bachert, C, Akdis, M, Auffray, C, Annesi-Maesano, I, Bindslev-Jensen, C, Cambon-Thomsen, A, Carlsen, K H, Chatzi, L, Forastiere, F, Garcia-Aymerich, J, Gehring, Ulrike, Guerra, S, Heinrich, J, Koppelman, G H, Kowalski, M L, Lambrecht, B, Lupinek, C, Maier, D, Melén, E, Momas, I, Palkonen, S, Pinart, M, Postma, D, Siroux, V, Smit, H A, Sunyer, J, Wright, J, Zuberbier, T, Arshad, S H, Nadif, R, Thijs, C, Andersson, N, Asarnoj, A, Ballardini, N, Ballereau, S, Bedbrook, A, Benet, M, Bergstrom, A, Brunekreef, B, Burte, E, Calderon, M, De Carlo, G, Demoly, P, Eller, E, Fantini, M P, Hammad, H, Hohman, C, Just, J, Kerkhof, M, Kogevinas, M, Kull, I, Lau, S, Lemonnier, N, Mommers, M, Nawijn, M, Neubauer, A, Oddie, S, Pellet, J, Pin, I, Porta, D, Saes, Y, Skrindo, I, Tischer, C G, Torrent, M, von Hertzen, L, Bousquet, J, Anto, J M, Wickman, M, Keil, T, Valenta, R, Haahtela, T, Lodrup Carlsen, K, van Hage, M, Akdis, C, Bachert, C, Akdis, M, Auffray, C, Annesi-Maesano, I, Bindslev-Jensen, C, Cambon-Thomsen, A, Carlsen, K H, Chatzi, L, Forastiere, F, Garcia-Aymerich, J, Gehring, Ulrike, Guerra, S, Heinrich, J, Koppelman, G H, Kowalski, M L, Lambrecht, B, Lupinek, C, Maier, D, Melén, E, Momas, I, Palkonen, S, Pinart, M, Postma, D, Siroux, V, Smit, H A, Sunyer, J, Wright, J, Zuberbier, T, Arshad, S H, Nadif, R, Thijs, C, Andersson, N, Asarnoj, A, Ballardini, N, Ballereau, S, Bedbrook, A, Benet, M, Bergstrom, A, Brunekreef, B, Burte, E, Calderon, M, De Carlo, G, Demoly, P, Eller, E, Fantini, M P, Hammad, H, Hohman, C, Just, J, Kerkhof, M, Kogevinas, M, Kull, I, Lau, S, Lemonnier, N, Mommers, M, Nawijn, M, Neubauer, A, Oddie, S, Pellet, J, Pin, I, Porta, D, Saes, Y, Skrindo, I, Tischer, C G, Torrent, M, and von Hertzen, L

Abstract

Allergic diseases [asthma, rhinitis and atopic dermatitis (AD)] are complex. They are associated with allergen-specific IgE and nonallergic mechanisms that may coexist in the same patient. In addition, these diseases tend to cluster and patients present concomitant or consecutive diseases (multimorbidity). IgE sensitization should be considered as a quantitative trait. Important clinical and immunological differences exist between mono- and polysensitized subjects. Multimorbidities of allergic diseases share common causal mechanisms that are only partly IgE-mediated. Persistence of allergic diseases over time is associated with multimorbidity and/or IgE polysensitization. The importance of the family history of allergy may decrease with age. This review puts forward the hypothesis that allergic multimorbidities and IgE polysensitization are associated and related to the persistence or re-occurrence of foetal type 2 signalling. Asthma, rhinitis and AD are manifestations of a common systemic immune imbalance (mesodermal origin) with specific patterns of remodelling (ectodermal or endodermal origin). This study proposes a new classification of IgE-mediated allergic diseases that allows the definition of novel phenotypes to (i) better understand genetic and epigenetic mechanisms, (ii) better stratify allergic preschool children for prognosis and (iii) propose novel strategies of treatment and prevention.

Published
2015

49. Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster

Author

Garcia-Aymerich, J, Benet, M, Saeys, Y, Pinart, M, Basagaña, X, Smit, H A, Siroux, V, Just, J, Momas, I, Rancière, F, Keil, T, Hohmann, C, Lau, S, Wahn, U, Heinrich, J, Tischer, C G, Fantini, M P, Lenzi, J, Porta, D, Koppelman, G H, Postma, D S, Berdel, D, Koletzko, S, Kerkhof, M, Gehring, U, Wickman, M, Melén, E, Hallberg, J, Bindslev-Jensen, C, Eller, E, Kull, I, Lødrup Carlsen, K C, Carlsen, K-H, Lambrecht, B N, Kogevinas, M, Sunyer, J, Kauffmann, F, Bousquet, J, Antó, J M, Garcia-Aymerich, J, Benet, M, Saeys, Y, Pinart, M, Basagaña, X, Smit, H A, Siroux, V, Just, J, Momas, I, Rancière, F, Keil, T, Hohmann, C, Lau, S, Wahn, U, Heinrich, J, Tischer, C G, Fantini, M P, Lenzi, J, Porta, D, Koppelman, G H, Postma, D S, Berdel, D, Koletzko, S, Kerkhof, M, Gehring, U, Wickman, M, Melén, E, Hallberg, J, Bindslev-Jensen, C, Eller, E, Kull, I, Lødrup Carlsen, K C, Carlsen, K-H, Lambrecht, B N, Kogevinas, M, Sunyer, J, Kauffmann, F, Bousquet, J, and Antó, J M

Abstract

BACKGROUND: Asthma, rhinitis and eczema often co-occur in children, but their interrelationships at the population level have been poorly addressed. We assessed co-occurrence of childhood asthma, rhinitis and eczema using unsupervised statistical techniques.METHODS: We included 17 209 children at 4 years and 14 585 at 8 years from seven European population-based birth cohorts (MeDALL project). At each age period, children were grouped, using partitioning cluster analysis, according to the distribution of 23 variables covering symptoms 'ever' and 'in the last 12 months', doctor diagnosis, age of onset and treatments of asthma, rhinitis and eczema; immunoglobulin E sensitization; weight; and height. We tested the sensitivity of our estimates to subject and variable selections, and to different statistical approaches, including latent class analysis and self-organizing maps.RESULTS: Two groups were identified as the optimal way to cluster the data at both age periods and in all sensitivity analyses. The first (reference) group at 4 and 8 years (including 70% and 79% of children, respectively) was characterized by a low prevalence of symptoms and sensitization, whereas the second (symptomatic) group exhibited more frequent symptoms and sensitization. Ninety-nine percentage of children with comorbidities (co-occurrence of asthma, rhinitis and/or eczema) were included in the symptomatic group at both ages. The children's characteristics in both groups were consistent in all sensitivity analyses.CONCLUSION: At 4 and 8 years, at the population level, asthma, rhinitis and eczema can be classified together as an allergic comorbidity cluster. Future research including time-repeated assessments and biological data will help understanding the interrelationships between these diseases.

Published
2015

50. Letter to the editor: Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes

Author

Casas, L, Sunyer, J, Tischer, C, Gehring, U, Wickman, M, Garcia-Esteban, R, Lehmann, I, Kull, I, Reich, A, Lau, S, Wijga, A, Antó, J M, Nawrot, T S, Heinrich, J, Keil, T, Torrent, M, Casas, L, Sunyer, J, Tischer, C, Gehring, U, Wickman, M, Garcia-Esteban, R, Lehmann, I, Kull, I, Reich, A, Lau, S, Wijga, A, Antó, J M, Nawrot, T S, Heinrich, J, Keil, T, and Torrent, M

Published
2015

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