1. Nanoclay particles as a stem cell adhesion factor in polyvinyl alcohol hydrogel-based wound dressings
- Author
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Renani, Mohammad Mojmeli, Nazarpak, Masoumeh Haghbin, Solati-Hashjin, Mehran, and Mahdavi, Hamid
- Subjects
Tissue engineering -- Research ,Montmorillonite -- Research ,Stem cells -- Research ,Skin -- Research ,Clay -- Research ,Wounds and injuries -- Care and treatment ,Engineering and manufacturing industries ,Science and technology - Abstract
As the primary goal in the wound care intervention is the promotion of rapid wound healing, researchers sought to find a remedy. In this progression course, nanocomposite-based hydrogels have attracted the attention. Herein, we used a polyvinyl alcohol (PVA) hydrogel in combination with two forms of clay nanoparticles, namely unmodified montmorillonite (MONT) and modified (OMONT), to fabricate a nanocomposite-based hydrogels and combat the lack of stem cells' adhesion to PVA, followed by seeding of adipose-derived stem cells (ADSCs) on them. To investigate the characteristics of these constructs, corresponding tests were performed. The Young's modulus and elongation at break of PVA/5% OMONT were 3.7 [+ or -] 0.014 and 800 [+ or -] 35, respectively, which were higher than those of PVA/5% MONT (3 [+ or -] 0.03 and 320 [+ or -] 14). In addition, the hardness of the modified group (7.2 [+ or -] 0.07) was lower than the unmodified one (9.8 [+ or -] 0.07). The water vapor transmission rate (WVTR) in the OMONT group was 39 [+ or -] 0.28, which was lower than PVA/5% MONT (46 [+ or -] 4.24). Hence, ADSCs/PVA montmorillonite dressing may improve wound healing and provide a new way to employ stem cells, significantly impacting skin tissue engineering safely. Highlights * Modified montmorillonite had higher stem cell binding. * The lack of stem cells' adhesion to polyvinyl alcohol (PVA) was solved. * Adipose-derived stem cells/PVA montmorillonite dressing may improve wound healing. * It is a novel promising approach for skin tissue engineering. KEYWORDS montmorillonite, nanocomposites, PVA hydrogel, stem cells, 1 | INTRODUCTION As the primary goal in the wound care intervention is the promotion of rapid wound healing, researchers sought to find a remedy. (1) In this progression course, [...]
- Published
- 2024
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