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Nidhish Tiwari,1,2 Nidhi Madan3 1Department of Internal Medicine, Jacobi Medical Center, Bronx, NY, USA; 2Department of Internal Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; 3Department of Cardiology, Rush University Medical Center, Chicago, IL, USA Abstract: Aortic stenosis (AS) is the most common valvular heart disease in the elderly and it causes significant morbidity and mortality. Hypertension is also highly prevalent in elderly patients with AS, and AS patients with hypertension have worse outcomes. Accurate assessment of AS severity and understanding its relationship with arterial compliance has become increasingly important as the options for valve management, particularly transcatheter interventions, have grown. The parameters used for quantifying stenosis severity have traditionally mainly focused on the valve itself. However, AS is now recognized as a systemic disease involving aging ventricles and stiff arteries rather than one limited solely to the valve. Over the last decade, valvuloarterial impedance, a measure of global ventricular load, has contributed to our understanding of the pathophysiology and course of AS in heterogeneous patients, even when segregated by symptoms and severity. This review summarizes our growing understanding of the interplay between ventricle, valve, and vessel, with a particular emphasis on downstream vascular changes after transcatheter aortic valve replacement and the role of valvuloarterial impedance in predicting left ventricular changes and prognosis in patients with various transvalvular flow patterns. Keywords: aortic stenosis, transcatheter aortic valve replacement, global ventricular load, ventriculoarterial coupling, arterial compliance, valvuloarterial impedance

Edlira Zere,1,* Prabhat Kumar Chaudhari,2,* Jitendra Sharan,3 Kunaal Dhingra,4 Nitesh Tiwari5 1Department of Orthodontic and Craniofacial Anomalies, School of Graduate Dentistry, Rambam Health Care Campus, Technion Faculty of Medicine, Haifa, Israel; 2Division of Orthodontics and Dentofacial Deformities, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India; 3Department of Dentistry, All India Institute of Medical Sciences, Bhubaneswar, India; 4Division of Periodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India; 5Division of Pedodontics and Preventive Dentistry, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India *These authors contributed equally to this work Abstract: Class III malocclusion represents a growth-related dentofacial deformity with mandibular prognathism in relation to the maxilla and/or cranial base. Its prevalence varies greatly among and within different races, ethnic groups, and geographic regions studied. Class III malocclusion has a multifactorial etiology, which is the expression of a moderate distortion of normal development as a result of interaction between innate factors or genetic hereditary with environmental factors. Various skeletal topographies of underlying Class III malocclusion are due to discrepancy in the maxillary and mandibular growth along with vertical and/or transverse problems apart from sagittal malformations. The spectrum of complications for Class III malocclusion ranges in gravity from dentoalveolar problems with functional anterior shift of the mandible to true skeletal problems with serious maxillomandibular discrepancies, which makes its diagnosis highly challenging in growing children. Concern regarding early treatment and the need for interceptive care in the case of Class III malocclusion has always been a dilemma, knowing that not all problems will be solved in these cases until maxillomandibular growth is further completed, and the long-term outcome of various treatment approaches may depend on the growth tendency of an individual. Interceptive treatment of Class III malocclusions should be undertaken if it prevents damage to the oral tissues and/or significantly reduces the amount or severity of future orthodontic and surgical interventions. This paper presents an overview of developing Class III malocclusion, with the emphasis on challenges and their solutions based on the best current available evidence. Keywords: Class III malocclusion, facemask therapy, maxillary expansion, chin cup appliance, bone-anchored maxillary protraction, growth treatment response vector

Gabion weir comprises porous materials packed with distinct shapes and sizes of gravel. The gabion weir is eco-friendlier than an impervious weir, as its opening enables water life and sediment materials to pass through it. Aeration is how natural processes or physical structures enhance the contact area and time between water and estranged air. This process improves the dissolved oxygen (D.O.) of water. The D.O. is one of the best determinants used for water quality measurement. This paper investigates the prediction of mass oxygen transfer over the gabion weir by ensemble models. The outputs of gabion weir oxygen mass transfer were estimated using bagging, boosting, and stacking by taking input parameters such as average size, porosity, the gabion weir height, discharge per unit width, and drop height. The dataset was taken by conducting experiments. By comparing these modeling ensembles, it was found that random forest-based bagging outperformed all proposed models. Nevertheless, all applied ensemble models were performing well, but published traditional equations were performing incredibly poorly. As sensitivity analysis suggests, the discharge per unit width was the most sensitive input. An uncertainty study was also carried out. [ABSTRACT FROM AUTHOR]