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Summary Nail disorders in general are difficult to treat and often frustrating, and this is also the case with nail psoriasis, especially when it is limited to the nails, and not affecting joints. The quality of life of patients with nail psoriasis is negatively affected, owing to the chronic course of the disease and frequent relapses. The purpose of this study was to compare treatment response and maintenance of response during follow-up of 12 patients with nail matrix psoriasis limited to a few nails, who were treated with intralesional injections of either methotrexate (MTX) 25 mg/mL or triamcinolone acetonide 10 mg/mL. Patients were treated every 6 weeks for 24 weeks and followed up for 6 months. Photographic documentation and assessment by Nail Psoriasis Severity Index were performed during each treatment session and at each follow-up visit. At the end of the four treatment sessions, all patients had improvement of their disease, which continued during follow-up, especially for the MTX-treated group.

Background Onychopapilloma is a benign tumor of the distal nail matrix and proximal nail bed with heterogeneous clinical presentations. It poses a diagnostic challenge because it could mimic subungual malignancies and inflammatory conditions. Clinical, onychoscopic, and histopathological clues play critical roles in diagnosis. Methods We performed a retrospective chart review of onychopapilloma cases collected over 10 years, and characterized the clinical, onychoscopic, and histopathological features of onychopapilloma at an academic institution. Results We obtained 17 biopsy-confirmed cases of onychopapilloma. Among our cases, we found manifestation of onychopapilloma as longitudinal erythronychia, longitudinal leukonychia, yellow-brown chromonychia, and longitudinal melanonychia. Long longitudinal or short splinter hemorrhages may be present. Distal fissuring with V-shaped notch, subungual keratotic mass, and onycholysis are other discernable features. Histopathological features include papillomatosis, epidermal hyperplasia, acanthosis of the distal nail bed, premature keratinization, matrix metaplasia, hyperkeratosis, and splinter hemorrhages; histopathological signs of malignancy were not observed in any of our cases. Conclusions Onychopapilloma has polymorphic clinical and morphological features. Onychoscopic and histopathological studies are important to help exclude malignant mimickers. Consider onychopapilloma in the differential diagnoses of a monodactylous longitudinal streak in the nail, especially on the left thumb of an adult female.

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Coatings are often required to provide multiple properties that seem to be opposed to one another, or at least difficult to obtain at the same time. One key example for waterborne acrylic coatings is the desire for lower volatile organic compounds (VOC) without the loss of hardness properties. Coupling these seemingly conflicting properties with other high performance needs, such as excellent corrosion resistance and weatherability, can present a serious challenge for raw material suppliers and coatings manufacturers alike. A new waterborne technology that satisfies these many requirements will be introduced. This paper describes a unique acrylic/urethane hybrid technology which couples a hard acrylic dominant phase with a soft polyurethane minor phase, and the development of a new self-crosslinking hybrid polymer which combines the low VOC/fast hardness development balance with excellent corrosion resistance and weatherability in a single-component waterborne system. In the hybrid, the soft polyurethane phase acts as a conduit for the rapid diffusion and release of coalescent from the film, leading to improved hardness development relative to a hard acrylic alone. The soft polyurethane phase also contributes to good film formation at reduced VOC levels. The mechanism of the faster coalescent release will be discussed, along with application data showing improvements in block, print and dirt pickup resistance. The excellent corrosion resistance and durability are a consequence of the formation of polymer–pigment composite particles and a film formation process that offers improved pigment distribution in the dry film. Details of the mechanism will be discussed, along with performance properties of the new acrylic/urethane hybrid polymer in corrosion-resistant coatings for the protection of metal.