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Abstract Importance Most unwanted sexual contact victimization (USCV) research utilizes predominantly white, cisgender, heterosexual college student samples. Estimates of USCV prevalence and demographic variation can determine the need for dedicated funding and culturally relevant campus services for students in high-risk groups. Objective To estimate the national prevalence and demographic variation in self-reported USCV within the first three months of college. Design Data are from the Sexual Assault Prevention for Undergrads (SAPU) (2020–2021) dataset. SAPU is an online intervention program administered to students on more than 600 college campuses in the United States (N = 250,359). Group differences were assessed by race/ethnicity, gender identity, and sexual identity, and then stratified by gender to assess within-gender group differences. Setting The SAPU dataset includes public and private institutions and 2-year and 4-year colleges with varying sizes of enrollment. Participants The sample is demographically diverse, and consists of newly matriculated U.S. college students, most of whom complete the SAPU program within the first three months of enrollment. Main outcomes and measures The primary outcome measure is self-reported USCV within the first three months of college enrollment, analyzed for subgroup differences. We hypothesized that USCV would be higher among students from racial/ethnic, gender, and sexual minority populations. Results Nearly 8% of transgender men reported USCV, followed by 7.4% of transgender women, 7.4% of genderqueer/gender non-conforming students, 4.5% of women, and 1.5% of men. Several subgroups reported exceedingly high rates of USCV, including Black students who identified as transgender women (35.7%) and American Indian/Alaska Native/Native Hawaiian/Pacific Islander students who identified as trans men (55.6%) or genderqueer/gender non-conforming (41.7%). Conclusions and relevance Universal and targeted (selective and indicated) intervention programs are needed to lessen USCV, particularly among gender minority students who also identify as Black, Indigenous, other person of color, or as a sexual minority.

Abstract Background School-based drug use prevention programs have demonstrated notable potential to reduce the onset and escalation of drug use, including among youth at risk of poor outcomes such as those exposed to trauma. Researchers have found a robust relationship between intervention fidelity and participant (i.e., student) outcomes. Effective implementation of evidence-based interventions, such as the Michigan Model for HealthTM (MMH), is critical to achieving desired public health objectives. Yet, a persistent gap remains in what we know works and how to effectively translate these findings into routine practice. The objective of this study is to design and test a multi-component implementation strategy to tailor MMH to meet population needs (i.e., students exposed to trauma), and improve the population-context fit to enhance fidelity and effectiveness. Methods Using a 2-group, mixed-method randomized controlled trial design, this study will compare standard implementation versus Enhanced Replicating Effective Programs (REP) to deliver MMH. REP is a theoretically based implementation strategy that promotes evidence-based intervention (EBI) fidelity through a combination of EBI curriculum packaging, training, and as-needed technical assistance and is consistent with standard MMH implementation. Enhanced REP will tailor the intervention and training to integrate trauma-informed approaches and deploy customized implementation support (i.e., facilitation). The research will address the following specific aims: (1) design and test an implementation strategy (Enhanced REP) to deliver the MMH versus standard implementation and evaluate feasibility, acceptability, and appropriateness using mixed methods, (2) estimate the costs and cost-effectiveness of Enhanced REP to deliver MMH versus standard implementation. Discussion This research will design and test a multi-component implementation strategy focused on enhancing the fit between the intervention and population needs while maintaining fidelity to MMH core functions. We focus on the feasibility of deploying the implementation strategy bundle and costing methods and preliminary information on cost input distributions. The substantive focus on youth at heightened risk of drug use and its consequences due to trauma exposure is significant because of the public health impact of prevention. Pilot studies of implementation strategies are underutilized and can provide vital information on designing and testing effective strategies by addressing potential design and methods uncertainties and the effects of the implementation strategy on implementation and student outcomes. Trial registration NCT04752189—registered on 8 February 2021 on ClinicalTrials.gov PRS

Casein kinase 2 (CK2) is an evolutionarily conserved serine/threonine kinase implicated in a wide range of cellular functions and known to be dysregulated in various diseases such as cancer. Compared to most other kinases, CK2 exhibits several unusual properties, including dual co-substrate specificity and a high degree of promiscuity with hundreds of substrates described to date. Most paradoxical, however, is its apparent constitutive activity: no definitive mode of catalytic regulation has thus far been identified. Here we demonstrate that copper enhances the enzymatic activity of CK2 both in vitro and in vivo. We show that copper binds directly to CK2, and we identify specific residues in the catalytic subunit of the enzyme that are critical for copper-binding. We further demonstrate that increased levels of intracellular copper result in enhanced CK2 kinase activity, while decreased copper import results in reduced CK2 activity. Taken together, these findings establish CK2 as a copper-regulated kinase and indicate that copper is a key modulator of CK2-dependent signaling pathways.

Author(s): Lisa Fedina [sup.1] , Sunghyun Hong [sup.1] , Ashley Rousson [sup.2] , Laurie Graham [sup.3] , Jungeun Olivia Lee [sup.4] , Todd I. Herrenkohl [sup.1] Author Affiliations: (1) https://ror.org/00jmfr291, [...], Purpose Early experiences of childhood maltreatment have been linked to intimate partner violence (IPV) later in adulthood. Few studies, however, have examined the prospective relationship between child maltreatment and IPV perpetration in the context of proximal and distal risk factors for violence, such as depression and alcohol misuse. Method Data from 370 adult respondents are from the Lehigh Longitudinal Study. Child maltreatment was measured prospectively at preschool ages and school-ages. Proximal and distal risk factors for adult IPV perpetration were measured in adolescence and at two time points in adulthood (age 36 and 46 years of age, on average). Hierarchical regression models were used to examine the prediction of IPV perpetration from earlier time points. Results Results indicate that exposure to child maltreatment, frequent alcohol use in adolescence, adolescent depression, frequent alcohol use at age 36, and adult depression at age 36 are predictive of IPV perpetration at age 36. Adolescent aggression and frequent alcohol use at age 46 were significantly predictive of IPV perpetration at age 46. Conclusions Findings identify multiple points across the life course for intervention. Interventions targeting adolescent and adult mental health and alcohol use may lessen the risk for adult IPV perpetration.

Numerous authors reported a prevalence of perfectionism in gifted populations. In addition, an unhealthy form of perfectionism that leads to anxiety disorder has been described. Using self-report measures (CAPS and R-CMAS) with 132 children, we hypothesized that intellectually gifted children express a higher level of perfectionism and anxiety. Our results pointed out a paradox: the gifted group obtained a higher self-oriented perfectionism score than the control group in 6th grade, but present the same level of anxiety. In contrast, the gifted group showed the same level of perfectionism than non-gifted 5(th) graders, but reported a higher anxiety level. Thus, the interplay between perfectionism and anxiety appears to be more complex than a simple linear relationship in giftedness.

We present the current status of the WASP search for transiting exoplanets, focusing on recent planet discoveries from SuperWASP-North and the joint equatorial region (-20≤Dec≤+20) observed by both WASP telescopes. We report the results of monitoring of WASP planets, and discuss how these contribute to our understanding of planet properties and their diversity.

In recirculating accelerators, and, in particular, energy-recovery linacs, the maximum current can be limited by multipass, multibunch beam breakup (BBU), which occurs when the electron beam interacts with the higher-order modes (HOMs) of an accelerating cavity on the accelerating pass and again on the energy recovering pass. This effect is of particular concern in the design of modern high average current energy-recovery accelerators utilizing superconducting rf technology. Experimental characterization and observations of the instability at the Jefferson Laboratory 10 kW free electron laser (FEL) are presented. Measurements of the threshold current for the instability are made under a variety of beam conditions and compared to the predictions of several BBU simulation codes. This represents the first time in which the codes have been experimentally benchmarked. With BBU posing a threat to high current beam operation in the FEL driver, several suppression schemes were developed. These include direct damping of the dangerous HOM using cavity feedback and modifying the electron beam optics so as to reduce the coupling between the beam and mode. Both methods were shown to increase the threshold current for stability. Beam optical suppression techniques, in particular, have proved to be so effective that they are routinely used in the normal operations of the FEL Upgrade Driver.

The multipass, multibunch beam breakup (BBU) instability imposes a potentially severe limitation to the average current that can be accelerated in an energy-recovery linac. Simulation results for Jefferson Lab’s free electron laser (FEL) upgrade driver are presented which predict the occurrence of BBU below the nominal operating current of the machine. In agreement with simulation, BBU was observed and preliminary measurements to identify the higher-order mode causing the instability are shown. In addition, measurements performed to experimentally determine the threshold current are described. Using a newly developed two-dimensional BBU simulation code, we study the effect of optical suppression techniques, first proposed in 1980 [R. E. Rand and T. I. Smith, Part. Accel. 11, 1 (1980)PLACBD0031-2460], on the threshold current of the FEL. Specifically we consider the effect of (1) reflecting the betatron planes about an axis that is at 45° between the vertical and horizontal axes and (2) rotating the betatron planes by 90°. In two-pass recirculators, a 90° rotation can be effective at increasing the threshold current for BBU. The successful installation of a five skew-quadrupole reflector in the backleg of the FEL has been shown to be effective at suppressing the instability and comments on preliminary operational experience will be given.

We present an experimental and theoretical study of the effect of desynchronism modulation on short pulse free-electron laser (FEL) oscillators. We find that the output power and the micropulse length of the FEL beam oscillate periodically at the modulation frequency and that the minimum micropulse length during the cycle can be significantly shorter than that which can be obtained without modulation. For example, when the desynchronism of our FEL is modulated at 40 kHz, the minimum measured micropulse length is 300 fs. Without modulation the minimum is about 700 fs. We show that when the desynchronism is modulated, the FEL can operate for part of the cycle in the normally inaccessible portion of the output power curve where the FEL gain is less than the cavity losses. It is even possible for the FEL to operate periodically in the region of negative desynchronism where gain, as normally defined, does not exist.

Magnetic dispersion followed by off-phase rf acceleration and an energy spectrometer were used to measure the longitudinal density profile of bunched relativistic electron beams with a resolution approaching 100 fs. Various electron bunch shapes were measured by this method and compared to bunch length measurements derived from the spectra of coherent transition radiation produced as the bunches traversed a thin foil. A reasonable agreement was found between the two bunch length methods. The off-phase rf acceleration method was then used to observe the modulated profile of a microbunched electron beam at the exit of a far-infrared free electron laser oscillator. In a preliminary study of the relationship between optical cavity power and the microbunch distribution, the density modulation and the energy spread of the electron beam were seen to increase as the optical field strength increased.

This study explores formal and informal intimate partner violence (IPV) service use among women and transgender/nonbinary individuals in the state of Michigan during the COVID-19 pandemic. A total of 14.8% (N = 173) of participants experienced IPV during this period, and 70% utilized at least one formal IPV service (13.3%). Up to 22% of survivors reported wanting to seek formal help but not doing so due to fear of partner reprisal, contracting COVID-19, or COVID-related service reductions. White, pregnant, and part-time-employed survivors were most likely to seek informal help. Older, higher-income, white, part-time-employed, pregnant, and non-essential worker survivors were most likely to seek formal help. [ABSTRACT FROM AUTHOR]

This paper examines the contrast and distinction between divergent and convergent scientific creativity, and the paradoxical relationship of scientific creativity with cultural factors in elementary students. With a newly developed measure of potential for scientific creativity, EPoC Science (Lubart et al., in press), students produce ideas in response to scientific problems, and both divergent-exploratory as well as convergent-integrative processes involved in scientific creativity are analyzed. An empirical study (n = 118) was conducted in France with elementary school children (ages 7-10). The divergent-exploratory task was scored for fluency and statistical uniqueness. For the convergent-integrative task, the number of concepts that a student integrated and synthesized, and the originality of the synthesis were scored. Results showed that divergent and convergent task performances were weakly related to each other. This suggests that divergence and convergence are two relatively distinct processes for scientific creativity, and that the relation is more complex than commonly assumed. In terms of culture-related variables, immigrant cultural background (number of family members born outside of France) was significantly and negatively correlated with the originality of divergent and convergent scientific creativity. Findings are discussed and educational implications are proposed.

For families with an early history of parental abuse and neglect (EHPAN), personal and situational stressors can increase relational vulnerabilities. We examined relationship dynamics between midlife adults with EHPAN and their parents during the first year of the COVID-19 pandemic. Analysis of semi-structured qualitative interviews with 31 participants (aged 44–50), examined patterns of contact and support to provide insights into relationship dynamics and relational changes experienced during the pandemic. Three relational themes characterized midlife adult child-parent relationships during COVID-19: tightening ties with parents while taking few COVID-19 precautions; keeping customary ties to maintain the status quo centered around instrumental support; loosening ties in which the relationship drifted. We found areas of resilience and vulnerabilities within each type of relationship. Recognizing that past adversity continues to shape relationship dynamics throughout the life course underscores the need for further research to identify factors that contribute to long-term family resilience and challenges. [ABSTRACT FROM AUTHOR]

Background/Context: The literature review by Phelps in this special issue highlights the challenges of research-practice partnerships and other forms of insider-outsider collaboration in education. In addition to addressing well-known challenges, this case study article focuses on the full-service community school model as a strategy to address holistic needs of students, families, and staff in poverty-impacted school contexts. Purpose/Objective/Research Question/Focus of Study: This article documents work that was conducted across five years, when a large research university partnered with an urban elementary school to establish a full-service community school. It provides an account of the assets, challenges, and processes that impacted our work, from the planning phase through four years of implementation. It describes efforts around four main areas: academic excellence, extended learning, holistic health and wellness, and family engagement. Research Design: This is a participatory case study with university educators and researchers working collaboratively with school professionals, community-based organizations, and families. Data Collection and Analysis: Many sources of data were included in our case analysis, including formative and summative student assessments, student attendance, service referrals, and office referrals for behavior. Running records of meetings, documentation of events, presentations, and reports submitted were also included. Interviews with key actors in the project were also collected and analyzed. Conclusions/Recommendations: Our partnership experienced some of the major challenges discussed in the literature. Turnover was overwhelmingly the most significant challenge. Student mobility and district boundary changes, new curricular adoptions for mathematics and literacy, new student assessments, new data tracking system, new bell times, and measures to cut transportation costs also impacted the effort. In spite of these challenges, we also experienced important successes. Centering relationships in our work has been an essential part of the success we experienced and is itself a success. At every phase, we remained at the table together, working to build relationships and sharing visions, goals, and practices. This resulted in important changes with stronger systems for tracking and using student data in educational decision making, health and wellness services now available to all students, and a universal social-emotional curriculum now in place. Family engagement and parent leadership are now essential dimensions of the school, with parents of color playing important roles to amplify their own and other parents' voices. Preservice teachers learned about full-service community schools in situ. We highlight the rich and complex narrative that emerged, which is not simply one of challenge but also one of resilience and strength. Carefully documenting this initiative can contribute to guiding implementation and refinement of a full-service community school model.