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152 results on '"Todeschini, Adriane R."'

1. List of contributors

Author

Agatemor, Christian, primary, Alisson-Silva, Frederico, additional, Allman, Sarah A., additional, Ardá, Ana, additional, Barone, Daniela, additional, Crost, Emmanuelle H., additional, Cunningham, Stephen, additional, Cutine, Anabela M., additional, de-Freitas-Junior, Julio C.M., additional, Dias, Wagner B., additional, Dorris, Emma, additional, Fadda, Elisa, additional, Ferreira, Carlos R., additional, Flannery, Andrea, additional, Franconetti, Antonio, additional, Gerlach, Jared Q., additional, Gill, Satbir Kaur, additional, Gómez, Marcos, additional, Ha, Lisa, additional, Hickey, Rita M., additional, Jiménez-Barbero, Jesús, additional, Joshi, Lokesh, additional, Juge, Nathalie, additional, Jukes, Margaret, additional, Kilcoyne, Michelle, additional, Lane, Jonathan A., additional, Latousakis, Dimitrios, additional, Li, Ting, additional, Liu, Yang, additional, Loponte, Hector F.B.R., additional, Makshakova, Olga, additional, Mann, Matthew D., additional, Mariño, Karina V., additional, Muthiah, Keerthana, additional, Oommen, Anup Mammen, additional, O’Gara, James P., additional, Osman, Adam, additional, Pavão, Mauro S.G., additional, Perez, Serge, additional, Poveda, Ana, additional, Rossignol, Francis, additional, Rudnicka, Karolina, additional, Santos, Ronan C., additional, Schwetz, Tara A., additional, Tabak, Lawrence A., additional, Teixeira, Felipe C.O.B., additional, Todeschini, Adriane R., additional, van Sinderen, Douwe, additional, Vasconcelos-dos-Santos, Andréia, additional, Walsh, Clodagh, additional, Wang, Xinyue, additional, and Yarema, Kevin J., additional

Published
2024
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2. Protein glycosylation in cancer

Author

Dias, Wagner B., primary, Vasconcelos-dos-Santos, Andréia, additional, Loponte, Hector F.B.R., additional, Teixeira, Felipe C.O.B., additional, Santos, Ronan C., additional, de-Freitas-Junior, Julio C.M., additional, Pavão, Mauro S.G., additional, Alisson-Silva, Frederico, additional, and Todeschini, Adriane R., additional

Published
2024
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6. Inhibition of O-GlcNAcylation Reduces Cell Viability and Autophagy and Increases Sensitivity to Chemotherapeutic Temozolomide in Glioblastoma

Author

Leonel, Amanda V., primary, Alisson-Silva, Frederico, additional, Santos, Ronan C. M., additional, Silva-Aguiar, Rodrigo P., additional, Gomes, Julia C., additional, Longo, Gabriel M. C., additional, Faria, Bruna M., additional, Siqueira, Mariana S., additional, Pereira, Miria G., additional, Vasconcelos-dos-Santos, Andreia, additional, Chiarini, Luciana B., additional, Slawson, Chad, additional, Caruso-Neves, Celso, additional, Romão, Luciana, additional, Travassos, Leonardo H., additional, Carneiro, Katia, additional, Todeschini, Adriane R., additional, and Dias, Wagner B., additional

Published
2023
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7. Chapter 9 - Protein glycosylation in cancer

Author

Dias, Wagner B., Vasconcelos-dos-Santos, Andréia, Loponte, Hector F.B.R., Teixeira, Felipe C.O.B., Santos, Ronan C., de-Freitas-Junior, Julio C.M., Pavão, Mauro S.G., Alisson-Silva, Frederico, and Todeschini, Adriane R.

Published
2024
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8. Data from Hyperglycemia Enhances Cancer Immune Evasion by Inducing Alternative Macrophage Polarization through Increased O-GlcNAcylation

Author

Rodrigues Mantuano, Natália, primary, Stanczak, Michal A., primary, Oliveira, Isadora de Araújo, primary, Kirchhammer, Nicole, primary, Filardy, Alessandra A., primary, Monaco, Gianni, primary, Santos, Ronan Christian, primary, Fonseca, Agatha Carlos, primary, Fontes, Miguel, primary, Bastos, César de Souza, primary, Dias, Wagner B., primary, Zippelius, Alfred, primary, Todeschini, Adriane R., primary, and Läubli, Heinz, primary

Published
2023
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9. Supplementary Figures from Hyperglycemia Enhances Cancer Immune Evasion by Inducing Alternative Macrophage Polarization through Increased O-GlcNAcylation

Author

Rodrigues Mantuano, Natália, primary, Stanczak, Michal A., primary, Oliveira, Isadora de Araújo, primary, Kirchhammer, Nicole, primary, Filardy, Alessandra A., primary, Monaco, Gianni, primary, Santos, Ronan Christian, primary, Fonseca, Agatha Carlos, primary, Fontes, Miguel, primary, Bastos, César de Souza, primary, Dias, Wagner B., primary, Zippelius, Alfred, primary, Todeschini, Adriane R., primary, and Läubli, Heinz, primary

Published
2023
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14. Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes

Author

Nardy, Ana Flávia F.R., Luiz da Silva Filho, João, Pérez, Ana Rosa, de Meis, Juliana, Farias-de-Oliveira, Désio Aurélio, Penha, Luciana, de Araújo Oliveira, Isadora, Dias, Wagner B., Todeschini, Adriane R., Freire-de-Lima, Célio Geraldo, Bellio, Maria, Caruso-Neves, Celso, Pinheiro, Ana Acácia, Takiya, Christina Maeda, Bottasso, Oscar, Savino, Wilson, and Morrot, Alexandre

Published
2013
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18. Biological evaluation and molecular modeling of peptidomimetic compounds as inhibitors for O-GlcNAc transferase (OGT)

Author

Albuquerque, Suraby O., primary, Barros, Thalita G., additional, Dias, Luiza R.S., additional, Lima, Camilo H. da S., additional, Azevedo, Pedro H.R. de A., additional, Flores-Junior, Luiz A.P., additional, dos Santos, Eldio G., additional, Loponte, Hector F., additional, Pinheiro, Sergio, additional, Dias, Wagner B., additional, Muri, Estela M.F., additional, and Todeschini, Adriane R., additional

Published
2020
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19. Hyperglycemia Enhances Cancer Immune Evasion by Inducing Alternative Macrophage Polarization through Increased O-GlcNAcylation

Author

Rodrigues Mantuano, Natália, primary, Stanczak, Michal A., additional, Oliveira, Isadora de Araújo, additional, Kirchhammer, Nicole, additional, Filardy, Alessandra A., additional, Monaco, Gianni, additional, Santos, Ronan Christian, additional, Fonseca, Agatha Carlos, additional, Fontes, Miguel, additional, Bastos, César de Souza, additional, Dias, Wagner B., additional, Zippelius, Alfred, additional, Todeschini, Adriane R., additional, and Läubli, Heinz, additional

Published
2020
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20. Heterogeneity in the biosynthesis of Mucin O-Glycans from Trypanosoma cruzi Tulahuen Strain with the expression of novel Galactofuranosyl-containing Oligosaccharides

Author

Jones, Christopher, Todeschini, Adriane R., Argellos, Orlando A.., Previato, Jose O., and Mendonca-Previato, Lucia

Subjects
Oligosaccharides -- Research, Trypanosoma cruzi -- Research, Mucins -- Research, Biosynthesis -- Research, Biological sciences, Chemistry
Abstract

The structure of novel linear and branched alpha-O-GlcNAc-linked oligosaccharides present on the mucins of the T. cruzi Tulahuen strain is determined. The determination of the structures of the O-glycans from T. cruzi Tulahuen mucins confirms by strain specificity of the glycosylation and predicts a relationship between it and parasite pathogenicity and the epidemiology of Chagas' disease D

Published
2004

22. Trends in Nanomedicines for Cancer Treatment

Author

do Nascimento, Tatielle, primary, Todeschini, Adriane R., additional, Santos-Oliveira, Ralph, additional, de Souza de Bustamante Monteiro, Mariana S., additional, de Souza, Vilênia T., additional, and Ricci-Júnior, Eduardo, additional

Published
2020
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26. Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation

Author

Mantuano, Natália Rodrigues, primary, Stanczak, Michal A., additional, de Araújo Oliveira, Isadora, additional, Kirchhammer, Nicole, additional, Filardy, Alessandra, additional, Monaco, Gianni, additional, Santos, Ronan Christian, additional, Fonseca, Agatha Carlos, additional, Fontes, Miguel, additional, de Souza Bastos, César, additional, Dias, Wagner B., additional, Zippelius, Alfred, additional, Todeschini, Adriane R., additional, and Läubli, Heinz, additional

Published
2019
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31. Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp

Author

Previato Jose O, Mendonça-Previato Lucia, Ottenhoff Tom HM, Mohana-Borges Ronaldo, Silva Carlos AM, de Lima Cristiana S, Todeschini Adriane R, Portugal Michelle I, and Pessolani Maria CV

Subjects
Microbiology, QR1-502
Abstract

Abstract Background The histone-like Hlp protein is emerging as a key component in mycobacterial pathogenesis, being involved in the initial events of host colonization by interacting with laminin and glycosaminoglycans (GAGs). In the present study, nuclear magnetic resonance (NMR) was used to map the binding site(s) of Hlp to heparan sulfate and identify the nature of the amino acid residues directly involved in this interaction. Results The capacity of a panel of 30 mer synthetic peptides covering the full length of Hlp to bind to heparin/heparan sulfate was analyzed by solid phase assays, NMR, and affinity chromatography. An additional active region between the residues Gly46 and Ala60 was defined at the N-terminal domain of Hlp, expanding the previously defined heparin-binding site between Thr31 and Phe50. Additionally, the C-terminus, rich in Lys residues, was confirmed as another heparan sulfate binding region. The amino acids in Hlp identified as mediators in the interaction with heparan sulfate were Arg, Val, Ile, Lys, Phe, and Thr. Conclusion Our data indicate that Hlp interacts with heparan sulfate through two distinct regions of the protein. Both heparan sulfate-binding regions here defined are preserved in all mycobacterial Hlp homologues that have been sequenced, suggesting important but possibly divergent roles for this surface-exposed protein in both pathogenic and saprophic species.

Published
2008
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32. The major surface carbohydrates of the Echinococcus granulosus cyst: mucin-type O-glycans decorated by novel galactose-based structures

Author

Diaz, Alvaro, Fontana, E. Carolina, Todeschini, Adriane R., Soule, Silvia, Gonzalez, Humberto, Casaravilla, Cecilia, Portela, Magdalena, Mohana-Borges, Ronaldo, Mendonca-Previato, Lucia, Previato, Jose O., and Ferreira, Fernando

Subjects
Carbohydrates -- Chemical properties, Galactose -- Chemical properties, Nuclear magnetic resonance spectroscopy -- Usage, Biological sciences, Chemistry
Abstract

MS and NMR techniques are employed to characterize purified structure of glycans isolated from the massive layer of carbohydrate-rich extracellular matrix (laminated layer) which outwardly protect the human cestode Echinococcus granulosus. The results revealed that the E. granulosus cyst exposes to the host only a few different major carbohydrate motifs which are composed essentially of galactose units and include the elongation by [(Galp[beta]1-3).sub.n] and the capping by Galp[alpha]1-4, novel in animal mucin-type O-glycans.

Published
2009

34. Trends in Nanotechnology for in vivoCancer Diagnosis: Products and Patents

Author

do Nascimento, Tatielle, Tavares, Melanie, Monteiro, Mariana S.S.B., Santos-Oliveira, Ralph, Todeschini, Adriane R., Souza, Vilênia T. de, and Ricci-Júnior, Eduardo

Abstract

Background: Cancer is a set of diseases formed by abnormal growth of cells leading to the formation of the tumor. The diagnosis can be made through symptoms’ evaluation or imaging tests, however, the techniques are limited and the tumor detection may be late. Thus, pharmaceutical nanotechnology has emerged to optimize the cancer diagnosis through nanostructured contrast agent’s development. Objective: This review aims to identify commercialized nanomedicines and patents for cancer diagnosis. Methods: The databases used for scientific articles research were Pubmed, Science Direct, Scielo and Lilacs. Research on companies’ websites and articles for the recognition of commercial nanomedicines was performed. The Derwent tool was applied for patent research. Results: This article aimed to research on nanosystems based on nanoparticles, dendrimers, liposomes, composites and quantum dots, associated to imaging techniques. Commercialized products based on metal and composite nanoparticles, associated with magnetic resonance and computed tomography, have been observed. The research conducted through Derwent tool displayed a small number of patents using nanotechnology for cancer diagnosis. Among these patents, the most significant number was related to the use of systems based on metal nanoparticles, composites and quantum dots. Conclusion: Although few systems are found in the market and patented, nanotechnology appears as a promising field for the development of new nanosystems in order to optimize and accelerate the cancer diagnosis.

Published
2020
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35. Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation

Author

Lucena, Miguel C., primary, Carvalho-Cruz, Patricia, additional, Donadio, Joana L., additional, Oliveira, Isadora A., additional, de Queiroz, Rafaela M., additional, Marinho-Carvalho, Monica M., additional, Sola-Penna, Mauro, additional, de Paula, Iron F., additional, Gondim, Katia C., additional, McComb, Mark E., additional, Costello, Catherine E., additional, Whelan, Stephen A., additional, Todeschini, Adriane R., additional, and Dias, Wagner B., additional

Published
2016
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36. Cellular glycosylation senses metabolic changes and modulates cell plasticity during epithelial to mesenchymal transition.

Author

Carvalho‐cruz, Patricia, Alisson‐Silva, Frederico, Todeschini, Adriane R., and Dias, Wagner B.

Abstract

Epithelial to mesenchymal transition (EMT) is a developmental program reactivated by tumor cells that leads to the switch from epithelial to mesenchymal phenotype. During EMT, cells are transcriptionally regulated to decrease E‐cadherin expression while expressing mesenchymal markers such as vimentin, fibronectin, and N‐cadherin. Growing body of evidences suggest that cells engaged in EMT undergo a metabolic reprograming process, redirecting glucose flux toward hexosamine biosynthesis pathway (HBP), which fuels aberrant glycosylation patterns that are extensively observed in cancer cells. HBP depends on nutrient availability to produce its end product UDP‐GlcNAc, and for this reason is considered a metabolic sensor pathway. UDP‐GlcNAc is the substrate used for the synthesis of major types of glycosylation, including O‐GlcNAc and cell surface glycans. In general, the rate limiting enzyme of HBP, GFAT, is overexpressed in many cancer types that present EMT features as well as aberrant glycosylation. Moreover, altered levels of O‐GlcNAcylation can modulate cell morphology and favor EMT. In this review, we summarize some of the current knowledge that correlates glucose metabolism, aberrant glycosylation and hyper O‐GlcNAcylation supported by HBP that leads to EMT activation. Developmental Dynamics 247:481–491, 2018. © 2017 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2018
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43. Further structural characterization of the Echinococcus granulosus laminated layer carbohydrates: The blood-antigen P1-motif gives rise to branches at different points of the O-glycan chains

Author

Lin, Gerardo, primary, Todeschini, Adriane R, additional, Koizumi, Akihiko, additional, Neves, Jorge L, additional, González, Humberto, additional, Dematteis, Sylvia, additional, Hada, Noriyasu, additional, Previato, Jose O, additional, Ferreira, Fernando, additional, Mendonça-Previato, Lucia, additional, and Díaz, Alvaro, additional

Published
2012
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47. The Major Surface Carbohydrates of theEchinococcus granulosusCyst: Mucin-TypeO-Glycans Decorated by Novel Galactose-Based Structures

Author

Díaz, Alvaro, primary, Fontana, E. Carolina, additional, Todeschini, Adriane R., additional, Soulé, Silvia, additional, González, Humberto, additional, Casaravilla, Cecilia, additional, Portela, Magdalena, additional, Mohana-Borges, Ronaldo, additional, Mendonça-Previato, Lucia, additional, Previato, Jose O., additional, and Ferreira, Fernando, additional

Published
2009
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49. Endophytic colonization of rice (Oryza sativa L.) by the diazotrophic bacterium Burkholderia kururiensis and its ability to enhance plant growth

Author

Mattos, Katherine A., primary, Pádua, Vania L.M., additional, Romeiro, Alexandre, additional, Hallack, Leticia F., additional, Neves, Bianca C., additional, Ulisses, Tecia M.U., additional, Barros, Claudia F., additional, Todeschini, Adriane R., additional, Previato, José O., additional, and Mendonça-Previato, Lucia, additional

Published
2008
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