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48. Aluminium Overload of Parathyroid Glands in Haemodialysed Patients with Hyperparathyroidism: Effect on Bone Remodelling.

Author

Berland, Y., Charbit, M., Henry, J. F., Toga, M., Cano, J. P., and Olmer, M.

Abstract

In the course of chronic renal failure, aluminium may deposit and accumulate in different tissues. The aluminium content of parathyroid glands was measured in 31 haemodialysis patients at the time of a parathyroidectomy. The values were compared with those obtained from ten control patients with primary hyperparathyroidism without renal failure, and were related to bone remodelling. Of the 31 patients, 27 had a bone biopsy after double tetracycline labelling, at the time of parathyroidectomy. Twenty-one patients had severe hyperparathyroidism, three patients had hyperparathyroidism associated with osteomalacia, three patients had mild hyperparathyroidism with reduced bone formation. Seven patients had bone aluminium deposits, associated with osteomalacia in one case. The parathyroid aluminium was 62 ± 35.7 (μmol/g glandular dry weight) in haemodialysis patients and 14.3 ± 6.3 in control patients ( <0.001). A significant positive correlation existed between parathyroid aluminium and serum aluminium (

Published
1988

49. Localization of lactoferrin and nonspecific cross-reacting antigen in human breast carcinomas. An immunohistochemical study using the avidin-biotin-peroxidase complex method.

Author

Charpin, Colette, Lachard, Alain, Pourreau-Schneider, Natalie, Jacquemier, Jocelyne, Lavaut, Marie Noëlle, Andonian, Claudie, Martin, Pierre Marie, Toga, Maurice, Charpin, C, Lachard, A, Pourreau-Schneider, N, Jacquemier, J, Lavaut, M N, Andonian, C, Martin, P M, and Toga, M

Published
1985
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