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191 results on '"Tognetto D."'

1. Validation of Esaso Classification of Diabetic Maculopathy

Author

Panozzo, G., Franzolin, E., Giannarelli, Diana, Dalla Mura, G., Longo, Anita Rosa, Cicinelli, M. V., Angelini, E., Airaghi, P., Avitabile, T., Bandello, F., Beccastrini, A., Benedetti, G., Bertuzzi, Paolo Francesco, Bonfiglio, V. M. E., Boscia, F., Carnevali, A., Carosielli, M., Cereda, M. G., Contardi, C., Coppola, M., Costagliola, C., Cristofolini, R., Cucciniello, P., D'Aloisio, R., De Bernardo, M., De Filippis, Alessandro, Dell'Omo, Roberto, Di Paola, I., Dell'Acqua, Massimiliano, Franco, Alessio, Grassi, M. O., Gregori, G., Gusson, E., Lattanzio, R., Lanzetta, P., Longo, A., Marchini, G., Marolo, P., Mastropasqua, R., Bertoldo, G. M., Monteleone, Giorgio, Ortisi, E., Parisi, Giuseppe, Parrulli, S., Pucci, P., Pastore, M. R., Reibaldi, M., Rizzo, Stanislao, Romano, Federica, Rosa, N., Sarao, V., Scarpa, G., Scorcia, V., Scupola, Andrea, Staurenghi, G., Sunseri Trapani, V., Tognetto, D., Trabucchi, G., Vaccaro, S., Vadala, M., Veritti, D., Vinciguerra, A. L., Zanzottera, E. C., Giannarelli D., Longo R., Bertuzzi F., De Filippis A., Dell'Omo R., Dell'Acqua M., Franco A., Monteleone G., Parisi G., Rizzo S. (ORCID:0000-0001-6302-063X), Romano F., Scupola A., Panozzo, G., Franzolin, E., Giannarelli, Diana, Dalla Mura, G., Longo, Anita Rosa, Cicinelli, M. V., Angelini, E., Airaghi, P., Avitabile, T., Bandello, F., Beccastrini, A., Benedetti, G., Bertuzzi, Paolo Francesco, Bonfiglio, V. M. E., Boscia, F., Carnevali, A., Carosielli, M., Cereda, M. G., Contardi, C., Coppola, M., Costagliola, C., Cristofolini, R., Cucciniello, P., D'Aloisio, R., De Bernardo, M., De Filippis, Alessandro, Dell'Omo, Roberto, Di Paola, I., Dell'Acqua, Massimiliano, Franco, Alessio, Grassi, M. O., Gregori, G., Gusson, E., Lattanzio, R., Lanzetta, P., Longo, A., Marchini, G., Marolo, P., Mastropasqua, R., Bertoldo, G. M., Monteleone, Giorgio, Ortisi, E., Parisi, Giuseppe, Parrulli, S., Pucci, P., Pastore, M. R., Reibaldi, M., Rizzo, Stanislao, Romano, Federica, Rosa, N., Sarao, V., Scarpa, G., Scorcia, V., Scupola, Andrea, Staurenghi, G., Sunseri Trapani, V., Tognetto, D., Trabucchi, G., Vaccaro, S., Vadala, M., Veritti, D., Vinciguerra, A. L., Zanzottera, E. C., Giannarelli D., Longo R., Bertuzzi F., De Filippis A., Dell'Omo R., Dell'Acqua M., Franco A., Monteleone G., Parisi G., Rizzo S. (ORCID:0000-0001-6302-063X), Romano F., and Scupola A.

Abstract

Purpose: To test reliability and reproducibility of ESASO morphologic OCT-based classification of diabetic maculopathy (DM). Methods: This is a multi-center cross-sectional study including a coordination center (CC) and 18 participating centers (PCs). After instruction on the correct use of ESASO Classification, the validation process was carried out in two consecutive stages. In the first retrospective phase, we evaluated the concordance between PCs and CC in the staging of OCT images collected during PCs’ daily activity (608 images). In a second prospective phase, we analyzed the inter-observer agreement of staging assigned by each PCs to OCT images selected by the CC (22 images). Results: The overall concordance achieved in the retrospective phase was 89.8% (Kappa = 0.83 (95% CI: 0.78–0.87); p<0.0001). In 99.5% of cases, concordance did not differ by more than one stage. In the prospective phase, PCs reached an inter-operator agreement of 93.0% (Krippendorff's Alpha = 0.953, 95% CI: 0.929–0.977, p<0.0001). Any discrepancy among the 22 images was within one stage. Conclusion: The results achieved in this study confirm that ESASO OCT-based Classification can be considered as an easy and reproducible method to stage DM during clinical practice. A diffused use of a common and validated method to describe the progression of retinal damage in DM may offer several clinical and scientific advantages.

Published
2023

2. Macular Hole in Myopic Eyes: A Narrative Review of the Current Surgical Techniques

Author

De Giacinto, C., Pastore, M. R., Cirigliano, G., Tognetto, D., Azzolini, C., De Giacinto, C., Pastore, M. R., Cirigliano, G., Tognetto, D., and Azzolini, C.

Subjects
Scleral ectasia, medicine.medical_specialty, genetic structures, business.industry, Review Article, medicine.disease, eye diseases, Ophthalmology, lcsh:Ophthalmology, lcsh:RE1-994, medicine, Narrative review, sense organs, business, Macular hole
Abstract

Macular hole (MH) in myopic eyes is a disease arising from complex tractional forces exerted by vitreomacular interface, epiretinal tissue, and progressive scleral ectasia of the posterior ocular globe wall. This retinal disease requires vitreoretinal treatment for its repair, and the surgical intervention remains a challenge also for experienced surgeons. The aim of this review is to describe the current knowledge regarding the pathogenesis of MH in myopic eyes and to detail novel surgical techniques and technological advancements in its surgical management.

Published
2019
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3. Correction: One week of levofloxacin plus dexamethasone eye drops for cataract surgery: an innovative and rational therapeutic strategy (Eye, (2020), 10.1038/s41433-020-0869-1)

Author

Bandello, F., Coassin, M., Di Zazzo, A., Rizzo, S., Biagini, I., Pozdeyeva, N., Sinitsyn, M., Verzin, A., De Rosa, P., Calabro, F., Avitabile, T., Bonfiglio, V., Fasce, F., Barraquer, R., Mateu, J. L., Kohnen, T., Carnovali, M., Malyugin, B., Aragona, P., Arvedi, P., Cagini, C., Caretti, L., Cavallini, G. M., Cillino, S., Figini, I., Franco, L. M., La Mantia, A., Laborante, A., Lanzetta, P., Marcigaglia, M., Mariotti, C., Martini, E., Mastropasqua, L., Morselli, S., Passani, F., Pece, A., Pertile, G., Pioppo, A., Pirondini, C., Prantera, M., Rapisarda, A., Romano, M. R., Scarpa, G., Schiano-Lomoriello, D., Scorcia, V., Scuderi, G., Semeraro, F., Spedale, F., Staurenghi, G., Tognetto, D., Tosi, M., Trabucchi, G., Trivella, F., Villani, E., Vento, A., Vinciguerra, P., Alio, J. L., Alfonso Sanchez, J. F., Montiel, F. A., Lorenz, K., Panova, I., Eremina, A., Ciprandi, G., Bandello, F., Coassin, M., Di Zazzo, A., Rizzo, S., Biagini, I., Pozdeyeva, N., Sinitsyn, M., Verzin, A., De Rosa, P., Calabro, F., Avitabile, T., Bonfiglio, V., Fasce, F., Barraquer, R., Mateu, J. L., Kohnen, T., Carnovali, M., Malyugin, B., Aragona, P., Arvedi, P., Cagini, C., Caretti, L., Cavallini, G. M., Cillino, S., Figini, I., Franco, L. M., La Mantia, A., Laborante, A., Lanzetta, P., Marcigaglia, M., Mariotti, C., Martini, E., Mastropasqua, L., Morselli, S., Passani, F., Pece, A., Pertile, G., Pioppo, A., Pirondini, C., Prantera, M., Rapisarda, A., Romano, M. R., Scarpa, G., Schiano-Lomoriello, D., Scorcia, V., Scuderi, G., Semeraro, F., Spedale, F., Staurenghi, G., Tognetto, D., Tosi, M., Trabucchi, G., Trivella, F., Villani, E., Vento, A., Vinciguerra, P., Alio, J. L., Alfonso Sanchez, J. F., Montiel, F. A., Lorenz, K., Panova, I., Eremina, A., and Ciprandi, G.

Subjects
not available, Drug Therapy
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

4. Author Correction: Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study

Author

Rulli, Eliana, Quaranta, Luciano, Riva, Ivano, Poli, Davide, Hollander, Lital, Galli, Fabio, Katsanos, Andreas, Oddone, Francesco, Torri, Valter, Weinreb, N Varano L, Robert, Carchedi, T, Talarico, S, Frezzotti, P, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, V, Ungaro, N, Fossarello, M, Cucca, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, Gl, Jannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, V, Cassamali, M, Costagliola, C, Traverso, C, Scotto, R, Musolino, M, Landi, L, Bagnis, A., Rulli, Eliana, Quaranta, Luciano, Riva, Ivano, Poli, Davide, Hollander, Lital, Galli, Fabio, Katsanos, Andrea, Oddone, Francesco, Torri, Valter, Weinreb, Robert, N Varano L, Carchedi, T, Talarico, S, Frezzotti, P, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, V, Ungaro, N, Fossarello, M, Cucca, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, Gl, Jannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, V, Cassamali, M, Costagliola, C, Traverso, C, Scotto, R, Musolino, M, Landi, L, and Bagnis, A.

Subjects
Multidisciplinary, Open angle glaucoma, business.industry, Published Erratum, lcsh:R, MEDLINE, lcsh:Medicine, Italian Study Group on QoL in Glaucoma, Eye, Quality of life (healthcare), Medicine, Optometry, lcsh:Q, Visual field loss, business, lcsh:Science
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

5. Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients

Author

Riva, I, Legramandi, L, Rulli, E, Konstas, Ag, Katsanos, A, Oddone, F, Weinreb, Rn, Quaranta, L, Varano, L, Carchedi, T, Talarico, S, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, Ungaro, N, Fossarello, M, Cuccu, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, G, Iannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, Cassamali, M, Costagliola, C, Traverso, C, Scotto, R, Musolino, M, Landi, L, Bagnis, A, Riva I, Legramandi L, Rulli E, Konstas AG, Katsanos A, Oddone F, Weinreb RN, Quaranta L, Italian Study Group on QoL in Glaucoma: L Varano, T Carchedi, S Talarico, F Parravano, I Motolese, SA Bagaglia, GCM Rossi, S Lateri, L Bossolesi, L Carmassi, T Rolle, R Piccini, R Ratiglia, A Rossi, S Gandolfi, V Tagliavini, N Ungaro, M Fossarello, A Cuccu, I Zucca, M Uva, E Bonacci, G Cardarella, D Tognetto, O Vattovani, P Vallon, F Iannacone, L Fontana, S Marchi, GL Manni, D Jannetta, G Roberti, L Rossetti, E Maggiolo, O Oneta, C Sborgia, F Cantatore, L Mastropasqua, L Agnifili, E Campos, C Gizzi, G Giannaccare, V Pucci, M Cassamali, C Costagliola, C Traverso, R Scotto, M Musolino, L Landi, A Bagnis, Riva, Ivano, Legramandi, Lorenzo, Rulli, Eliana, Konstas, Anastasios G, Katsanos, Andrea, Oddone, Francesco, Weinreb, Robert N, Quaranta, Luciano, Varano, L, Carchedi, T, Talarico, S, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, Ungaro, N, Fossarello, M, Cuccu, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, Gl, Jannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, Cassamali, M, Costagliola, C, Traverso, C, Scotto, R, Musolino, M, Landi, L, and Bagnis, A.

Subjects
0301 basic medicine, Change over time, medicine.medical_specialty, Aging, Visual acuity, Open angle glaucoma, genetic structures, Population, lcsh:Medicine, Glaucoma, Diseases, Italian Study Group on QoL in Glaucoma, Neurodegenerative, Eye, Article, 03 medical and health sciences, Medical research, 0302 clinical medicine, Quality of life, Clinical Research, Settore MED/30, Internal medicine, medicine, POAG, lcsh:Science, education, Prospective cohort study, Author Correction, Eye Disease and Disorders of Vision, education.field_of_study, Multidisciplinary, business.industry, lcsh:R, Neurosciences, medicine.disease, primary open angle glaucoma, humanities, eye diseases, 030104 developmental biology, Symptom perception, glaucoma, quality of life, lcsh:Q, sense organs, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

To evaluate the change over time of vision-related quality of life (QoL) and glaucoma symptoms in a population of newly-diagnosed primary open angle glaucoma (POAG) patients. Multicenter, prospective study. Consecutive newly-diagnosed POAG patients were enrolled and followed-up for one year. Follow-up visits were scheduled at 6 and 12 months from baseline. At each visit, vision-related QoL and glaucoma-related symptoms were assessed by the means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the Glaucoma Symptom Scale (GSS), respectively. Trends over time for NEI-VFQ-25 and GSS scores were evaluated with longitudinal linear mixed models. One-hundred seventy-eight patients were included in the analysis. At baseline, early to moderate glaucoma stages were associated with higher scores for most GSS and NEI-VFQ-25 items, while lower best-corrected visual acuity was associated with lower scores for 4 of the 12 NEI-VFQ-25 items. During the follow-up, all the GSS scores, the NEI-VFQ-25 total score, and 7 of the 12 NEI-VFQ-25 scores significantly improved (p

Published
2019

6. Evaluating the Effects of an Ophthalmic Solution of Coenzyme Q10 and Vitamin E in Open-Angle Glaucoma Patients: A Study Protocol

Author

Quaranta, L., Riva, I., Biagioli, E., Rulli, E., Poli, D., Legramandi, L., Fossarello, M., Uva, M., Carmassi, L., Gandolfi, S., Rossi, G. C., Fontana, L., Rolle, T., Tognetto, D., Mastropasqua, L., Campos, E., Nucci, C., Scuderi, G., Marchini, G., Quaranta, L., Riva, I., Biagioli, E., Rulli, E., Poli, D., Legramandi, L., Fossarello, M., Uva, M., Carmassi, L., Gandolfi, S., Rossi, G. C., Fontana, L., Rolle, T., Tognetto, D., Mastropasqua, L., Campos, E., Nucci, C., Scuderi, G., and Marchini, G.

Subjects
Male, 030213 general clinical medicine, medicine.medical_specialty, Open angle glaucoma, medicine.drug_class, Ubiquinone, Glaucoma, Placebo, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, Double-Blind Method, law, Settore MED/30, Ophthalmology, medicine, Humans, Vitamin E, Pharmacology (medical), Open-angle glaucoma, Intraocular Pressure, Aged, Coenzyme Q10, business.industry, Hazard ratio, General Medicine, Prostaglandin analogue, Randomized clinical trial, Middle Aged, medicine.disease, Clinical trial, chemistry, 030220 oncology & carcinogenesis, Female, Ophthalmic Solutions, Visual Fields, business, Glaucoma, Open-Angle
Abstract

Introduction: The CoQun® study is a multicenter, controlled trial aimed to evaluate the neuroprotective effects of Coqun®, an ophthalmic solution of Coenzyme q10 (CoQ10) and Vitamin E (VitE), in patients affected by primary open-angle glaucoma (POAG). Pre-clinical studies and small non-controlled clinical trials have previously shown a potential role of CoQ10 and VitE in glaucoma neuroprotection, both in vitro and in vivo. Methods: Randomized, parallel arm, multicenter, double-blind study. POAG patients with an IOP ranging from 17 to 21 mm Hg on monotherapy with a prostaglandin analogue (PGA) will be considered for study enrollment. Inclusion criteria will be visual field (VF) mean deviation between − 4 and − 10 dB and VF Pattern Standard Deviation between 4 and 10 dB. Eligible patients will be randomized to receive CoQun® (Arm A) or placebo (Arm B), in addition to PGA monotherapy. Planned Outcomes: Primary outcome will be time to progression, defined as the time between the baseline visit and the visit with confirmed VF progression. A total of 612 patients are planned to be enrolled, to detect a hazard ratio of 0.65, with a power of 80% and an alpha error of 0.05 (two-sided). For study power calculation, 10% non-evaluable patients are assumed. This is the first study investigating, in a randomized, double-blind and controlled fashion, the neuroprotective effects of CoQ10 and VitE in POAG patients. Trial Registration: ClinicalTrials.gov identifier, NCT03611530.

Published
2019

7. Influence of Sociodemographic Factors on Disease Characteristics and Vision-related Quality of Life in Primary Open-angle Glaucoma Patients: The Italian Primary Open Angle Glaucoma Study (IPOAGS)

Author

Riva, Ivano, Legramandi, Lorenzo, Katsanos, Andreas, Oddone, Francesco, Rulli, Eliana, Roberti, Gloria, Quaranta Luciano, Varano L, Carchedi T, Talarico S, Parravano F, Motolese I, Bagaglia SA, Rossi GCM, Lateri S, Bossolesi L, Carmassi L, Rolle T, Piccini R, Ratiglia R, Rossi A, Gandolfi S, Tagliavini V, Ungaro N, Fossarello M, Cucca A, Zucca I, Uva M, Bonacci E, Cardarella G, Tognetto D, Vattovani O, Vallon P, Iannacone F, Fontana L, Marchi S, Manni GL, Jannetta D, Roberti G, Rossetti L, Maggiolo E, Oneta O, Sborgia C, Cantatore F, Mastropasqua L, Agnifili L, Campos E, Gizzi C, Giannaccare G, Pucci V, Cassamali M, Costagliola C, Scotto R, Musolino M, Landi L, Bagnis A., I Riva, L Legramandi, A Katsanos, F Oddone, E Rulli, G Roberti, L Quaranta, Italian Study Group on QoL in Glaucoma: L Varano, T Carchedi, S Talarico, F Parravano, I Motolese, SA Bagaglia, GCM Rossi, S Lateri, L Bossolesi, L Carmassi, T Rolle, R Piccini, R Ratiglia, A Rossi, S Gandolfi, V Tagliavini, N Ungaro, M Fossarello, A Cucca, I Zucca, M Uva, E Bonacci, G Cardarella, D Tognetto, O Vattovani, P Vallon, F Iannacone, L Fontana, S Marchi, GL Manni, D Jannetta, L Rossetti, E Maggiolo, O Oneta, C Sborgia, F Cantatore, L Mastropasqua, L Agnifili, E Campos, C Gizzi, G Giannaccare, V Pucci, M Cassamali, C Costagliola, C Traverso, R Scotto, M Musolino, L Landi, A Bagnis, Riva, Ivano, Legramandi, Lorenzo, Katsanos, Andrea, Oddone, Francesco, Rulli, Eliana, Roberti, Gloria, Quaranta, Luciano, Varano, L, Carchedi, T, Talarico, S, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, V, Ungaro, N, Fossarello, M, Cucca, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, Gl, Jannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, V, Cassamali, M, Costagliola, C, Scotto, R, Musolino, M, Landi, L, and Bagnis, A.

Subjects
Male, medicine.medical_specialty, Multivariate statistics, Visual acuity, Open angle glaucoma, genetic structures, Cross-sectional study, sociodemographic factors, Visual Acuity, Glaucoma, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Internal medicine, Settore MED/30, Sickness Impact Profile, Surveys and Questionnaires, medicine, Humans, 030212 general & internal medicine, Intraocular Pressure, Vision, Ocular, Aged, Demography, business.industry, Middle Aged, medicine.disease, eye diseases, glaucoma, quality of life, Ophthalmology, Cross-Sectional Studies, Italy, sociodemographic factor, 030221 ophthalmology & optometry, Quality of Life, Marital status, Disease characteristics, Female, medicine.symptom, business, Glaucoma, Open-Angle
Abstract

Purpose: The purpose of this article was to evaluate the potential association between sociodemographic factors with clinical characteristics, vision-related quality of life (QoL), and glaucoma-related symptoms scores in a large cohort of primary open-angle glaucoma patients. Materials and Methods: Multicenter, cross-sectional study involving academic and nonacademic centers. Previously diagnosed primary open-angle glaucoma patients aged >18 years were enrolled. At baseline, information on demographic characteristics, social, medical and ocular history, clinical presentation and treatments was collected. Vision-related QoL was evaluated by means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25), while glaucoma-related symptoms were evaluated using the Glaucoma Symptom Scale (GSS) questionnaire. The associations between sociodemographic factors with clinical characteristics (mean deviation, pattern standard deviation, best-corrected visual acuity), NEI-VFQ-25, and GSS scores were evaluated by means of univariate and multivariate general linear models. Results: A total of 3227 patients were enrolled. Older age and male sex were significantly associated with lower mean deviation (P

Published
2018

8. Comment on 'Anatomical and functional changes after dexamethasone implant and ranibizumab in diabetic macular edema: a retrospective cohort study'

Author

D'Aloisio, R, Mastropasqua, L, Di Staso, S, Mastropasqua, A, Di Antonio, L, Senatore, A, Ciancaglini, M, Di Nicola, M, Di Martino, G, Tognetto, D, and Toto, L

Subjects
medicine.medical_specialty, business.industry, Diabetic macular edema, MEDLINE, Retrospective cohort study, Ophthalmology, lcsh:Ophthalmology, lcsh:RE1-994, Medicine, Comment And Response, Implant, Ranibizumab, business, Dexamethasone, medicine.drug
Published
2020

9. Author Correction: Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients (Scientific Reports, (2019), 9, 1, (6735), 10.1038/s41598-019-43203-9)

Author

Riva, I., Legramandi, L., Rulli, E., Konstas, A. G., Katsanos, A., Oddone, F., Weinreb, R. N., Quaranta, L., Varano, L., Carchedi, T., Talarico, S., Frezzotti, P., Parravano, F., Motolese, I., Bagaglia, S. A., Rossi, G. C. M., Lateri, S., Bossolesi, L., Carmassi, L., Rolle, T., Piccini, R., Ratiglia, R., Rossi, A., Gandolfi, S., Tagliavini, V., Ungaro, N., Fossarello, M., Cuccu, A., Zucca, I., Uva, M., Bonacci, E., Cardarella, G., Tognetto, D., Vattovani, O., Vallon, P., Iannacone, F., Fontana, L., Marchi, S., Manni, G. L., Jannetta, D., Roberti, G., Rossetti, L., Maggiolo, E., Oneta, O., Sborgia, C., Cantatore, F., Mastropasqua, L., Agnifili, L., Campos, E., Gizzi, C., Giannaccare, G., Pucci, V., Cassamali, M., Costagliola, C., Traverso, C., Scotto, R., Musolino, M., Landi, L., and Bagnis, A.

Subjects
Settore MED/30
Published
2020

10. Author Correction: Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study (Scientific Reports, (2018), 8, 1, (619), 10.1038/s41598-017-19113-z)

Author

Rulli, E., Quaranta, L., Riva, I., Poli, D., Hollander, L., Galli, F., Katsanos, A., Oddone, F., Torri, V., Weinreb, R. N., Varano, L., Carchedi, T., Talarico, S., Frezzotti, P., Parravano, F., Motolese, I., Bagaglia, S. A., Rossi, G. C. M., Lateri, S., Bossolesi, L., Carmassi, L., Rolle, T., Piccini, R., Ratiglia, R., Rossi, A., Gandolfi, S., Tagliavini, V., Ungaro, N., Fossarello, M., Cucca, A., Zucca, I., Uva, M., Bonacci, E., Cardarella, G., Tognetto, D., Vattovani, O., Vallon, P., Iannacone, F., Fontana, L., Marchi, S., Manni, G. L., Jannetta, D., Roberti, G., Rossetti, L., Maggiolo, E., Oneta, O., Sborgia, C., Cantatore, F., Mastropasqua, L., Agnifili, L., Campos, E., Gizzi, C., Giannaccare, G., Pucci, V., Cassamali, M., Costagliola, C., Traverso, C., Scotto, R., Musolino, M., Landi, L., and Bagnis, A.

Subjects
Settore MED/30
Published
2020

11. Correction: One week of levofloxacin plus dexamethasone eye drops for cataract surgery: an innovative and rational therapeutic strategy (Eye, (2020), 34, 11, (2112-2122), 10.1038/s41433-020-0869-1)

Author

Bandello, F., Coassin, M., Di Zazzo, A., Rizzo, S., Biagini, I., Pozdeyeva, N., Sinitsyn, M., Verzin, A., De Rosa, P., Calabro, F., Avitabile, T., Bonfiglio, V., Fasce, F., Barraquer, R., Mateu, J. L., Kohnen, T., Carnovali, M., Malyugin, B., Aragona, P., Arvedi, P., Cagini, C., Caretti, L., Cavallini, G. M., Cillino, S., Figini, I., Franco, L. M., La Mantia, A., Laborante, A., Lanzetta, P., Marcigaglia, M., Mariotti, C., Martini, E., Mastropasqua, L., Morselli, S., Passani, F., Pece, A., Pertile, G., Pioppo, A., Pirondini, C., Prantera, M., Rapisarda, A., Romano, M. R., Scarpa, G., Schiano-Lomoriello, D., Scorcia, V., Scuderi, G., Semeraro, F., Spedale, F., Staurenghi, G., Tognetto, D., Tosi, M., Trabucchi, G., Trivella, F., Villani, E., Vento, A., Vinciguerra, P., Alio, J. L., Alfonso Sanchez, J. F., Montiel, F. A., Lorenz, K., Panova, I., Eremina, A., and Ciprandi, G.

Published
2020

14. Dexamethasone intravitreal implant in previously treated patients with diabetic macular edema: Subgroup analysis of the MEAD study

Author

Augustin, A. J., Kuppermann, B. D., Lanzetta, P., Loewenstein, A., X. -Y., Li, Cui, H., Hashad, Y., Whitcup, S. M., Abujamra, S., Acton, J., Ali, F., Antoszyk, A., Awh, C. C., Barak, A., Bartz-Schmidt, K. U., Baumal, C. R., Belfort, R. Jr., Bhende, M., Boyer, D. S., Bridges, W. Z. Jr., Brown, D. M., Carmichael, T., Carnevale, K., Casella, A. M., Chang, T., Chechik, D., Chen, S. -N., Chong, L. P., Chong, V., Corwin, J., Creuzot-Garcher, C., Cruess, A., Daniell, M., De Avila, M. P., De Moraes, H. V. Jr., Devenyi, R. G., Doft, B. H., Donaldson, M., Dreyer, R., Eliott, D., Engel, H. M., Ernest, J., Essman, T. F., Falcone, P. M., Fekrat, S., Ferencz, J. R., Ferreira, J. L., Figueira, J., Fiser, I., Foster, B., Fox, G. M., Freeman, W. R., Garg, S. P., Gillies, M., Glaser, D., Goldstein, B. G., Gomes, A. M. V., Gonder, J. R., Gopal, L., Gous, P., Gupta, A., Halperin, L., Han, D., Hariprasad, S. M., Holz, F. G., Kaiser, P., Kalvodova, B., Katz, B., Katz, R. S., Kecik, D., Kellaway, J., Klemperer, I., Lattanzio, R., Lee, W. -K., Lehr, J., Leys, M., Loose, I., Lotery, A., D. -W., Lu, Mccartney, P., Majji, A. B., Martinez, J. A., Massin, P., Maturi, R. K., Menchini, U., Menon, G., Michels, M., Midena, E., Miller, J. Jr., Mitchell, P., Moisseiev, J., Morse, L., Navarro, R., Nemeth, J., Newland, H., Newsom, R., Nichols, J., Orellana, J., Orzalesi, N., Paranhos, A. Jr., Park, R., Park, S., Parodi, M. B., Pavan, P. R., Peace, J., Perez-Ortiz, D. J., Pollack, A., Ramaswamy, K., Ratnakaram, R., Ravalico, G., Rehak, J., Rezaei, K., Rizzo, S., Rodriguez-Alvira, F. J., Romanet, J. -P., Rose, S., Rosen, R. B., Rossetti, L., Ruiz-Moreno, J. M., Sadda, S., Sall, K., Sandner, D., Sanz, A. F. -V., Sartani, G., Schmickler, S., Schwartz, S. D., Sharma, Y. R., Sheu, S. -J., Singer, M., Sivaprasad, S., Soubrane, G., Soucek, P., Souied, E. H., Staurenghi, G., Studnicka, J., Suarez-Figueroa, M., Takahashi, W. Y., Tognetto, D., Tsai, P. L., Ulanski, L. J., H. S., Uy, Varano, M., Veith, M., Vicha, I., Viola, F., Visser, L., Weinberger, D., Wing, G. L., Wong, E., Wong, T. Y., Wylegala, E., Yan, J., Yoon, Y. H., Young, L. H., H. G., Yu, Zimmer-Galler, I. E., Augustin, Aj, Kuppermann, Bd, Lanzetta, P, Loewenstein, A, Li, Xy, Cui, H, Hashad, Y, Whitcup, Sm, on behalf of for the Ozurdex MEAD Study, Group, Battaglia Parodi, M, Augustin, A. J., Kuppermann, B. D., Lanzetta, P., Loewenstein, A., Li, X. -Y., Cui, H., Hashad, Y., Whitcup, S. M., Abujamra, S., Acton, J., Ali, F., Antoszyk, A., Awh, C. C., Barak, A., Bartz-Schmidt, K. U., Baumal, C. R., Belfort, R., Bhende, M., Boyer, D. S., Bridges, W. Z., Brown, D. M., Carmichael, T., Carnevale, K., Casella, A. M., Chang, T., Chechik, D., Chen, S. -N., Chong, L. P., Chong, V., Corwin, J., Creuzot-Garcher, C., Cruess, A., Daniell, M., De Avila, M. P., De Moraes, H. V., Devenyi, R. G., Doft, B. H., Donaldson, M., Dreyer, R., Eliott, D., Engel, H. M., Ernest, J., Essman, T. F., Falcone, P. M., Fekrat, S., Ferencz, J. R., Ferreira, J. L., Figueira, J., Fiser, I., Foster, B., Fox, G. M., Freeman, W. R., Garg, S. P., Gillies, M., Glaser, D., Goldstein, B. G., Gomes, A. M. V., Gonder, J. R., Gopal, L., Gous, P., Gupta, A., Halperin, L., Han, D., Hariprasad, S. M., Holz, F. G., Kaiser, P., Kalvodova, B., Katz, B., Katz, R. S., Kecik, D., Kellaway, J., Klemperer, I., Lattanzio, R., Lee, W. -K., Lehr, J., Leys, M., Loose, I., Lotery, A., Lu, D. -W., Mccartney, P., Majji, A. B., Martinez, J. A., Massin, P., Maturi, R. K., Menchini, U., Menon, G., Michels, M., Midena, E., Miller, J., Mitchell, P., Moisseiev, J., Morse, L., Navarro, R., Nemeth, J., Newland, H., Newsom, R., Nichols, J., Orellana, J., Orzalesi, N., Paranhos, A., Park, R., Park, S., Parodi, M. B., Pavan, P. R., Peace, J., Perez-Ortiz, D. J., Pollack, A., Ramaswamy, K., Ratnakaram, R., Ravalico, G., Rehak, J., Rezaei, K., Rizzo, S., Rodriguez-Alvira, F. J., Romanet, J. -P., Rose, S., Rosen, R. B., Rossetti, L., Ruiz-Moreno, J. M., Sadda, S., Sall, K., Sandner, D., Sanz, A. F. -V., Sartani, G., Schmickler, S., Schwartz, S. D., Sharma, Y. R., Sheu, S. -J., Singer, M., Sivaprasad, S., Soubrane, G., Soucek, P., Souied, E. H., Staurenghi, G., Studnicka, J., Suarez-Figueroa, M., Takahashi, W. Y., Tognetto, D., Tsai, P. L., Ulanski, L. J., Uy, H. S., Varano, M., Veith, M., Vicha, I., Viola, F., Visser, L., Weinberger, D., Wing, G. L., Wong, E., Wong, T. Y., Wylegala, E., Yan, J., Yoon, Y. H., Young, L. H., Yu, H. G., and Zimmer-Galler, I. E.

Subjects
Male, Vascular Endothelial Growth Factor A, Visual acuity, Triamcinolone acetonide, genetic structures, medicine.medical_treatment, Visual Acuity, Angiogenesis Inhibitors, Drug Implant, Triamcinolone Acetonide, Dexamethasone, Immunosuppressive Agent, Glucocorticoid, Diabetic retinopathy, Dexamethasone Intravitreal Implant, Corticosteroid, Drug delivery, Implant, Macular edema, Aged, Diabetic Retinopathy, Drug Implants, Female, Glucocorticoids, Humans, Immunosuppressive Agents, Intravitreal Injections, Macular Edema, Middle Aged, Retreatment, Tomography, Optical Coherence, Ophthalmology, Tomography, General Medicine, medicine.symptom, medicine.drug, Angiogenesis Inhibitor, Human, Research Article, medicine.medical_specialty, Subgroup analysis, medicine, business.industry, Intravitreal Injection, Cataract surgery, medicine.disease, eye diseases, Optical Coherence, business
Abstract

Dexamethasone intravitreal implant 0.7 mg (DEX 0.7) was approved for treatment of diabetic macular edema (DME) after demonstration of its efficacy and safety in the MEAD registration trials. We performed subgroup analysis of MEAD study results to evaluate the efficacy and safety of DEX 0.7 treatment in patients with previously treated DME. Three-year, randomized, sham-controlled phase 3 study in patients with DME, best-corrected visual acuity (BCVA) of 34–68 Early Treatment Diabetic Retinopathy Study letters (20/200–20/50 Snellen equivalent), and central retinal thickness (CRT) ≥300 μm measured by time-domain optical coherence tomography. Patients were randomized to 1 of 2 doses of DEX (0.7 mg or 0.35 mg), or to sham procedure, with retreatment no more than every 6 months. The primary endpoint was ≥15-letter gain in BCVA at study end. Average change in BCVA and CRT from baseline during the study (area-under-the-curve approach) and adverse events were also evaluated. The present subgroup analysis evaluated outcomes in patients randomized to DEX 0.7 (marketed dose) or sham based on prior treatment for DME at study entry. Baseline characteristics of previously treated DEX 0.7 (n = 247) and sham (n = 261) patients were similar. In the previously treated subgroup, mean number of treatments over 3 years was 4.1 for DEX 0.7 and 3.2 for sham, 21.5 % of DEX 0.7 patients versus 11.1 % of sham had ≥15-letter BCVA gain from baseline at study end (P = 0.002), mean average BCVA change from baseline was +3.2 letters with DEX 0.7 versus +1.5 letters with sham (P = 0.024), and mean average CRT change from baseline was −126.1 μm with DEX 0.7 versus −39.0 μm with sham (P

Published
2015

15. Health-related quality of life in patients with primary open-angle glaucoma. An Italian multicentre observational study

Author

Floriani, I., Quaranta, L., Rulli, E., Katsanos, A., Varano, L., Frezzotti, P., Rossi G. C., M., Carmassi, L., Rolle, T., Ratiglia, R., Gandolfi, S., Fossarello, M., Uva, BIANCA MARIA, Hollander, L., Poli, D., Grignolo, F., Roberto, A., Clivio, L., Galli, F., Carlucci, L., Riva, I., Delcassi, L., Carchedi, T., Talarico, S., Motolese, I., Bagaglia S., A., Lanteri, Silvia, Bossolesi, L., Piccini, R., Rossi, A., Tagliavini, V., Ungaro, N., Cuccu, A., Zucca, I., Bonacci, E., Cardarella, G., Tognetto, D., Vattovani, O., Vallon, P., Iannacone, F., Fontana, L., Marchi, S., Manni G., L., Jannetta, D., Roberti, G., Rossetti, L., Maggiolo, E., Oneta, O., Sborgia, C., Cantatore, F., Mastropasqua, L., Agnifili, L., Campos, E., Gizzi, C., Giannaccare, G., Pucci, V., Cassamali, M., Costagliola, C., Traverso, Carlo, Scotto, Riccardo, Musolino, Maria, Landi, L., and Bagnis, A.

Published
2016

17. Corneal autofluorescence in diabetes

Author

Tognetto D, Calderini F, Palomba MA, Busatto P, Battaglia Parodi M, Tognetto D, Tognetto, D, Calderini, F, Palomba, Ma, Busatto, P, and Battaglia Parodi, M

Published
1992

20. ANALYSIS OF THE QUALITY OF INTRAOCULAR LENSES

Author

Tognetto, D., Sanguinetti, G., Sirotti, Paolo, Cecchini, P., Marcucci, L., Ballone, E., Ravalico, G., D., Tognetto, G., Sanguinetti, Sirotti, Paolo, P., Cecchini, L., Marcucci, E., Ballone, and G., Ravalico

Published
2004

27. Su tre casi di sindrome di Terson

Author

Pastori G, Battaglia Parodi M, Rinaldi G, Tognetto D., Pastori, G., Battaglia Parodi, M., Rinaldi, G., Tognetto, Daniele, Pastori, G, Battaglia Parodi, M, Rinaldi, G, and Tognetto, D.

Subjects
sindrome di Terson
Published
1990

33. Efficacy of diclofenac eyedrops in preventing postoperative inflammation and long-term cystoid macular edema

Author

Gallenga, P. E., primary, Mastropasqua, L., additional, Lobefolo, L., additional, Loggia, Della C., additional, Ballone, E., additional, D’Annunzio, C., additional, Brancato, R., additional, Bandello, F., additional, Carones, F., additional, Sebastiani, A., additional, Capocotta, A., additional, Lamberti, G., additional, Ponte, F., additional, Cillino, A., additional, Morreale, S., additional, Neushüler, R., additional, Monaco, C., additional, Bucci, M. C., additional, Bonini, S., additional, Ravalico, G., additional, Tognetto, D., additional, Lovisato, A., additional, Menchini, U., additional, Lanzetta, P., additional, Mansutti, L., additional, and Bianco, S., additional

Published
1997
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40. One week of levofloxacin plus dexamethasone eye drops for cataract surgery: an innovative and rational therapeutic strategy

Author

Bandello, Francesco, Coassin, Marco, Di Zazzo, Antonio, Rizzo, Stanislao, Biagini, Ilaria, Pozdeyeva, Nadezhda, Sinitsyn, Maksim, Verzin, Alexander, De Rosa, Pasquale, Calabrò, Francesco, Avitabile, Teresio, Bonfiglio, Vincenza, Fasce, Francesco, Barraquer, Rafael, Mateu, Josè Lamarca, Kohnen, Thomas, Carnovali, Marino, Malyugin, Boris, Pasquale, Aragona, Paolo, Arvedi, Carlo, Cagini, Luigi, Caretti, Gian Maria Cavallini, Salvatore, Cillino, Innocente, Figini, Livio Marco Franco, Alberto La Mantia, Antonio, Laborante, Paolo, Lanzetta, Mattia, Marcigaglia, Cesare, Mariotti, Enrico, Martini, Leonardo, Mastropasqua, Simonetta, Morselli, Franco, Passani, Alfredo, Pece, Grazia, Pertile, Antonino, Pioppo, Cesare, Pirondini, Marcello, Prantera, Antonio, Rapisarda, Romano, Mario R., Giuseppe, Scarpa, Domenico, Schiano-Lomoriello, Vincenzo, Scorcia, Gianluca, Scuderi, Francesco, Semeraro, Franco, Spedale, Giovanni, Staurenghi, Tognetto, Daniele, Marco, Tosi, Giuseppe, Trabucchi, Fausto, Trivella, Edoardo, Villani, Andrea, Vento, Paolo, Vinciguerra, Alió, Jorge L., Alfonso Sanchez, Josè F., Francisco Arnalich Montiel, Katrin, Lorenz, Irina, Panova, Alena, Eremina, Giorgio, Ciprandi, Bandello F., Coassin M., Di Zazzo A., Rizzo S., Biagini I., Pozdeyeva N., Sinitsyn M., Verzin A., De Rosa P., Calabro F., Avitabile T., Bonfiglio V., Fasce F., Barraquer R., Mateu J.L., Kohnen T., Carnovali M., Malyugin B., Aragona P., Arvedi P., Cagini C., Caretti L., Cavallini G.M., Cillino S., Figini I., Franco L.M., La Mantia A., Laborante A., Lanzetta P., Marcigaglia M., Mariotti C., Martini E., Mastropasqua L., Morselli S., Passani F., Pece A., Pertile G., Pioppo A., Pirondini C., Prantera M., Rapisarda A., Romano M.R., Scarpa G., Schiano-Lomoriello D., Scorcia V., Scuderi G., Semeraro F., Spedale F., Staurenghi G., Tognetto D., Tosi M., Trabucchi G., Trivella F., Villani E., Vento A., Vinciguerra P., Alio J.L., Alfonso Sanchez J.F., Montiel F.A., Lorenz K., Panova I., Eremina A., Ciprandi G., Francesco, Bandello, Marco, Coassin, Antonio, Di Zazzo, Stanislao, Rizzo, Ilaria, Biagini, Nadezhda, Pozdeyeva, Maksim, Sinitsyn, Alexander, Verzin, Pasquale, De Rosa, Francesco, Calabrò, Teresio, Avitabile, Vincenza, Bonfiglio, Francesco, Fasce, Rafael, Barraquer, Josè Lamarca, Mateu, Thomas, Kohnen, Marino, Carnovali, Boris, Malyugin, Aragona, Pasquale, Arvedi, Paolo, Cagini, Carlo, Caretti, Luigi, Maria Cavallini, Gian, Cillino, Salvatore, Figini, Innocente, Marco Franco, Livio, La Mantia, Alberto, Laborante, Antonio, Lanzetta, Paolo, Marcigaglia, Mattia, Mariotti, Cesare, Martini, Enrico, Mastropasqua, Leonardo, Morselli, Simonetta, Passani, Franco, Pece, Alfredo, Pertile, Grazia, Pioppo, Antonino, Pirondini, Cesare, Prantera, Marcello, Rapisarda, Antonio, Romano, Mario R., Scarpa, Giuseppe, Schiano-Lomoriello, Domenico, Scorcia, Vincenzo, Scuderi, Gianluca, Semeraro, Francesco, Spedale, Franco, Staurenghi, Giovanni, Tognetto, Daniele, Tosi, Marco, Trabucchi, Giuseppe, Trivella, Fausto, Villani, Edoardo, Vento, Andrea, Vinciguerra, Paolo, Alió, Jorge L., Alfonso Sanchez, Josè F., Arnalich Montiel, Francisco, Lorenz, Katrin, Panova, Irina, Eremina, Alena, Ciprandi, Giorgio, Bandello, F., Coassin, M., Di Zazzo, A., Rizzo, S., Biagini, I., Pozdeyeva, N., Sinitsyn, M., Verzin, A., De Rosa, P., Calabro, F., Avitabile, T., Bonfiglio, V., Fasce, F., Barraquer, R., Mateu, J. L., Kohnen, T., Carnovali, M., Malyugin, B., Aragona, P., Arvedi, P., Cagini, C., Caretti, L., Cavallini, G. M., Cillino, S., Figini, I., Franco, L. M., La Mantia, A., Laborante, A., Lanzetta, P., Marcigaglia, M., Mariotti, C., Martini, E., Mastropasqua, L., Morselli, S., Passani, F., Pece, A., Pertile, G., Pioppo, A., Pirondini, C., Prantera, M., Rapisarda, A., Romano, M. R., Scarpa, G., Schiano-Lomoriello, D., Scorcia, V., Scuderi, G., Semeraro, F., Spedale, F., Staurenghi, G., Tognetto, D., Tosi, M., Trabucchi, G., Trivella, F., Villani, E., Vento, A., Vinciguerra, P., Alio, J. L., Alfonso Sanchez, J. F., Montiel, F. A., Lorenz, K., Panova, I., Eremina, A., and Ciprandi, G.

Subjects
medicine.medical_specialty, medicine.medical_treatment, Levofloxacin, Article, Dexamethasone, Cataract, 03 medical and health sciences, 0302 clinical medicine, Endophthalmitis, Pharmacotherapy, Postoperative Complications, Internal medicine, medicine, Tobramycin, Clinical endpoint, Humans, Endophthalmitis, Cataract, Intracameral cefuroxime, Adverse effect, business.industry, Cataract surgery, Intracameral cefuroxime, medicine.disease, not applicable, Anti-Bacterial Agents, Ophthalmology, Italy, Spain, 030221 ophthalmology & optometry, Ophthalmic Solutions, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Background: Cataract surgery is the most common operation performed worldwide. A fixed topical corticosteroid-antibiotic combination is usually prescribed in clinical practice for 2 or more weeks to treat post surgical inflammation and prevent infection. However, this protracted schedule may increase the incidence of corticosteroid-related adverse events and notably promote antibiotic resistance. Methods: This International, multicentre, randomized, blinded-assessor, parallel-group clinical study evaluated the non-inferiority of 1-week levofloxacin/dexamethasone eye drops, followed by 1-week dexamethasone alone, vs. 2-week gold-standard tobramycin/dexamethasone (one drop QID for all schedules) to prevent and treat ocular inflammation and prevent infection after uncomplicated cataract surgery. Non-inferiority was defined as the lower limit of the 95% confidence interval (CI) around a treatment difference >–10%. The study randomized 808 patients enrolled in 53 centres (Italy, Germany, Spain and Russia). The primary endpoint was the proportion of patients without anterior chamber inflammation on day 15 defined as the end of treatment. Endophthalmitis was the key secondary endpoint. This study is registered with EudraCT code: 2018-000286-36. Results: After the end of treatment, 95.2% of the patients in the test arm vs. 94.9% of the control arm had no signs of inflammation in the anterior chamber (difference between proportions of patients = 0.028; 95% CI: −0.0275/0.0331). No case of endophthalmitis was reported. No statistically significant difference was evident in any of the other secondary endpoints. Both treatments were well tolerated. Conclusions: Non-inferiority of the new short pharmacological strategy was proven. One week of levofloxacin/dexamethasone prevents infection, ensures complete control of inflammation in almost all patients and may contain antibiotic resistance.

Published
2020

41. Artificial intelligence applications and cataract management: A systematic review

Author

Daniele Tognetto, Magdalena Rejdak, Serena Milan, Mario Damiano Toro, Sandrine Zweifel, Rosa Giglio, Katarzyna Załuska-Ogryzek, Alex Lucia Vinciguerra, Robert Rejdak, University of Zurich, Giglio, Rosa, Tognetto, Daniele, Vinciguerra, Alex Lucia, Milan, Serena, Rejdak, Robert, Rejdak, Magdalena, Zaluska-Ogryzek, Katarzyna, Zweifel, Sandrine, Toro, Mario Damiano, Tognetto, D., Giglio, R., Vinciguerra, A. L., Milan, S., Rejdak, R., Rejdak, M., Zaluska-Ogryzek, K., Zweifel, S., and Toro, M. D.

Subjects
10018 Ophthalmology Clinic, medicine.medical_specialty, complications, diagnosis, media_common.quotation_subject, complication, 610 Medicine & health, Cataract, Postoperative management, law.invention, surgery, cataract management, Randomized controlled trial, Artificial Intelligence, law, medicine, artificial intelligence, intraocular lens calculation, Humans, Medical physics, Quality (business), Grading (education), media_common, business.industry, Evidence-based medicine, 2731 Ophthalmology, Quality of evidence, diagnosi, Ophthalmology, Systematic review, Applications of artificial intelligence, business, Human
Abstract

Artificial intelligence (AI)-based applications exhibit the potential to improve the quality and efficiency of patient care in different fields, including cataract management. A systematic review of the different applications of AI-based software on all aspects of a cataract patient's management, from diagnosis to follow-up, was carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All selected articles were analyzed to assess the level of evidence according to the Oxford Centre for Evidence-Based Medicine 2011 guidelines, and the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation system. Of the articles analyzed, 49 met the inclusion criteria. No data synthesis was possible for the heterogeneity of available data and the design of the available studies. The AI-driven diagnosis seemed to be comparable and, in selected cases, to even exceed the accuracy of experienced clinicians in classifying disease, supporting the operating room scheduling, and intraoperative and postoperative management of complications. Considering the heterogeneity of data analyzed, however, further randomized controlled trials to assess the efficacy and safety of AI application in the management of cataract should be highly warranted. (c) 2021 The Authors. Published by Elsevier Inc.

Published
2022
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42. Impact on refractive surgery due to increasing use of personal protection equipment: Insights from EUROCOVCAT group

Author

Isabel Prieto, Ozlem Evren Kemer, Cian Gildea, Robert Rejdak, Sandrine Zweifel, Mario Damiano Toro, Arthur B. Cummings, Daniele Tognetto, Antoine P. Brézin, Miguel A. Teus, Boris Malyugin, Omid Kermani, Cummings, Ab, Gildea, C, Brézin, Ap, Malyugin, Be, Evren Kemer, O, Kermani, O, Prieto, I, Rejdak, R, Teus, Ma, Tognetto, D, Zweifel, S, Toro, Md, University of Zurich, Toro, Mario D, Cummings, Arthur B, Gildea, Cian, Brézin, Antoine P, Malyugin, Boris E, Evren Kemer, Ozlem, Kermani, Omid, Prieto, Isabel, Rejdak, Robert, Teus, Miguel A, Tognetto, Daniele, and Zweifel, Sandrine

Subjects
10018 Ophthalmology Clinic, refractive lens exchange, medicine.medical_treatment, media_common.quotation_subject, COVID-19 pandemic, LASIK, Mask wearing, cataract surgery, fogging spectacles, refractive surgery, Communicable Disease Control, Humans, Pandemics, Personal Protective Equipment, SARS-CoV-2, COVID-19, Refractive Surgical Procedures, 610 Medicine & health, Masking (Electronic Health Record), Hygiene, Refractive surgery, Pandemic, medicine, Personal protective equipment, media_common, Social distance, Editorials, General Medicine, 2731 Ophthalmology, Independence, Ophthalmology, fogging spectacle, Optometry, Psychology, Psychosocial, Human
Abstract

Since the World Health Organization declared COVID-19 to be a pandemic on 11th March 2020, changes to social and sanitary practices have included significant issues in access and management of eye care during the COVID-19 pandemic. Additionally, the fear of loss, coupled with social distancing, lockdown, economic instability, and uncertainty, have led to a significant psychosocial impact that will have to be addressed. In the current COVID-19 pandemic, personal protective equipment such as face masks or face coverings have become a daily necessity. While “mass masking” along with hand hygiene and social distancing became more widespread, new issues began to emerge – particularly in those who wore spectacles as a means of vision correction. As we began to see routine patients again after the first lockdown had been lifted, many patients visited our clinics for refractive surgery consultations with a primary motivating factor of wanting spectacle independence due to the fogging of their spectacles as a result of wearing a mask. In this article, we report on new emerging issues in eye care due to the widespread use of masks and on the new unmet need in the corneal and cataract refractive surgery fields.

Published
2021
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43. A Deep Learning Method for Automatic Identification of Drusen and Macular Hole from Optical Coherence Tomography

Author

Teresa Pace, Nicolò Degan, Rosa Giglio Md, Daniele Tognetto Md, Agostino Accardo, Brigitte Séroussi, Patrick Weber, Ferdinand Dhombres, Cyril Grouin, Jan-David Liebe, Sylvia Pelayo, Andrea Pinna, Bastien Rance, Lucia Sacchi, Adrien Ugon, Arriel Benis, Parisis Gallos, Pace, T., Degan, N., Giglio, R., Tognetto, D., and Accardo, A.

Subjects
Drusen, Convolutional Neural Networks, Convolutional Neural Network, Retinal Perforations, Macular Hole, Retina, Deep Learning, Macular Holes, Optical Coherence Tomography, Retinal diseases, Humans, Tomography, Optical Coherence, Retinal Diseases, Optical Coherence, Retinal disease, Tomography, Human
Abstract

Deep Learning methods have become dominant in various fields of medical imaging, including ophthalmology. In this preliminary study, we investigated a method based on Convolutional Neural Network for the identification of drusen and macular hole from Optical Coherence Tomography scans with the aim to assist ophthalmologists in diagnosing and assessing retinal diseases.

Published
2022
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44. Intraoperative Anterior Segment Optical Coherence Tomography in the Management of Cataract Surgery: State of the Art

Author

Mario Damiano Toro, Serena Milan, Daniele Tognetto, Robert Rejdak, Ciro Costagliola, Sandrine Anne Zweifel, Chiara Posarelli, Michele Figus, Magdalena Rejdak, Teresio Avitabile, Adriano Carnevali, Rosa Giglio, Toro, Mario Damiano, Milan, Serena, Tognetto, Daniele, Rejdak, Robert, Costagliola, Ciro, Zweifel, Sandrine Anne, Posarelli, Chiara, Figus, Michele, Rejdak, Magdalena, Avitabile, Teresio, Carnevali, Adriano, Giglio, Rosa, Toro, M. D., Milan, S., Tognetto, D., Rejdak, R., Costagliola, C., Zweifel, S. A., Posarelli, C., Figus, M., Rejdak, M., Avitabile, T., Carnevali, A., and Giglio, R.

Subjects
anterior segment OCT, cataract surgery, intraoperative OCT, surgical technique, General Medicine
Abstract

Background: The introduction of non-invasive diagnostic tools in ophthalmology has significantly reshaped current clinical practice in different settings. Recently, different anterior segment (AS) intraoperative optical coherence tomography (i-OCT) systems have been employed for different interventional procedures including cataract surgery. Materials and Methods: A review on the use of AS i-OCT in the management of cataract surgery, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). The level of evidence according to the Oxford Centre for Evidence-Based Medicine (OCEM) 2011 guidelines, and the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system were assessed for all included articles. Results: Out of 6302 articles initially extracted, 6302 abstracts were identified for screening and 32 of these met the inclusion/exclusion criteria for full-text review; 19 articles were excluded. Conclusions: The use of AS i-OCT in cataract surgery, even if only a few studies have a high level or grade of evidence, may represent a useful tool for novel surgeons approaching phacoemulsification but also for expert ones for teaching purposes and to plan and manage complicated cases.

Published
2022

45. COVID-19 outbreak and increased risk of amblyopia and epidemic myopia: Insights from EUROCOVCAT group

Author

Miguel A. Teus, Daniele Tognetto, Boris Malyugin, Antoine P. Brézin, Arthur B. Cummings, Sandrine Zweifel, Mario Damiano Toro, Isabel Prieto, Omid Kermani, Dominique Bremond-Gignac, Ozlem Evren Kemer, Robert Rejdak, Toro, M. D., Bremond-Gignac, D., Brezin, A. P., Cummings, A. B., Kemer, O. E., Kermani, O., Malyugin, B. E., Prieto, I., Teus, M. A., Tognetto, D., Zweifel, S., Rejdak, R., Toro, Mario Damiano, Bremond-Gignac, Dominique, Brézin, Antoine Pierre, Cummings, Arthur Bernard, Kemer, Ozlem Evren, Kermani, Omid, Malyugin, Boris Edvard, Prieto, Isabel, Teus, Miguel Angel, Tognetto, Daniele, Zweifel, Sandrine, Rejdak, Robert, and University of Zurich

Subjects
10018 Ophthalmology Clinic, Adult, genetic structures, Coronavirus disease 2019 (COVID-19), Visual impairment, visual impairment, COVID-19 pandemic, 610 Medicine & health, pediatric-eye care, Amblyopia, World health, Disease Outbreaks, irreversible blindness, Pandemic, Myopia, Medicine, Humans, Child, Pandemics, amblyopia, Disease Outbreak, business.industry, SARS-CoV-2, Outbreak, COVID-19, General Medicine, irreversible blindne, 2731 Ophthalmology, eye diseases, ophthalmology, Increased risk, Common cause and special cause, Communicable Disease Control, Optometry, Abnormality, medicine.symptom, business, Human
Abstract

The most common cause of vision impairment in children is amblyopia. It is defined as impaired visual acuity in one or both eyes that is present with no demonstrable abnormality of the visual pathway and is not immediately resolved by wearing glasses. After the World Health Organization (WHO) recognized COVID-19 as a global pandemic on March 11, 2020, widespread changes and restrictions to social and sanitary practices have presented significant issues in access to eye care during the COVID-19 pandemic. A reduction of more than 80% in pediatric eye care volume up to its total cessation has been observed in different departments. In this scenario, reduced or absent eyesight, due to delay in timely treatment of amblyopic conditions, could create major, long-lasting effects on all aspects of life, including daily personal activities, interacting with the community, school and work opportunities and the ability to access public services. Processes coming out of lockdown should be gradually easing restrictions giving priority to ophthalmology and eye care facilities so that amblyopia does not remain unattended and irreversible as in adults due to lack of timely treatments. If not reversible, this process could lead to a dramatic increase in disability and unsustainable social costs for many governments.

Published
2022

46. Anatomical and functional changes after dexamethasone implant and ranibizumab in diabetic macular edema: a retrospective cohort study

Author

Marta Di Nicola, Leonardo Mastropasqua, Silvio Di Staso, Lisa Toto, Rossella D'Aloisio, Marco Ciancaglini, Luca Di Antonio, Alessandra Mastropasqua, Giuseppe Di Martino, Alfonso Senatore, Daniele Tognetto, Mastropasqua, L., Di Staso, S., D'Aloisio, R., Mastropasqua, A., Di Antonio, L., Senatore, A., Ciancaglini, M., Di Nicola, M., Di Martino, G., Tognetto, D., and Toto, L.

Subjects
medicine.medical_specialty, Visual acuity, genetic structures, optical coherence tomography angiography, 03 medical and health sciences, 0302 clinical medicine, lcsh:Ophthalmology, Clinical Research, Diabetic macular edema, Ophthalmology, medicine, Dexamethasone, intravitreal ranibizumab injections, Plexus, business.industry, Intravitreal ranibizumab injection, Retrospective cohort study, Intravitreal dexamethasone implant, Intravitreal ranibizumab injections, Optical coherence tomography angiography, eye diseases, intravitreal dexamethasone implant, lcsh:RE1-994, 030221 ophthalmology & optometry, Tonicity, Implant, Ranibizumab, medicine.symptom, business, diabetic macular edema, Microperimetry, medicine.drug
Abstract

AIM: To investigate the efficacy and safety of ranibizumab (RZB group) and dexamethasone implant (DEX group) intravitreal treatments in patients with treatment-naïve center involved diabetic macular edema (DME) by means of functional and morphological assessments. METHODS: This retrospective cohort study included 50 eyes of 50 patients with DME treated either with RBZ or DEX. Best-corrected visual acuity (BCVA) and microperimetry were evaluated at baseline and during a 6-month follow-up. In addition, central macular thickness (CMT) by means of structural optical coherence tomography (OCT) and retinal capillary plexus density and choriocapillary density by means of OCT angiography were assessed in all cases. RESULTS: Functional and morphological parameters significantly improved during the study period in both groups. BCVA improved significantly in both groups with a greater increase in the DEX group compared to the RBZ group (P=0.030). Microperimetry significantly differed during follow-up between the two treatments (P=0.031). In both groups CMT significantly decreased (P

Published
2019

47. Impact on Visual Acuity in Neovascular Age Related Macular Degeneration (nAMD) in Europe Due to COVID-19 Pandemic Lockdown

Author

Danielle Tognetto, Mario Damiano Toro, Boris Malyugin, Rosa Giglio, Sandrine Zweifel, Mehmet Onen, Miguel A. Teus, Carolina Arruabarrena, Robert Rejdak, Arruabarrena, Carolina, Toro, Mario Damiano, Onen, Mehmet, Malyugin, Boris E, Rejdak, Robert, Tognetto, Danielle, Zweifel, Sandrine, Giglio, Rosa, Teus, Miguel A, Arruabarrena, C., Toro, M. D., Onen, M., Malyugin, B. E., Rejdak, R., Tognetto, D., Zweifel, S., Giglio, R., Teus, M. A., and University of Zurich

Subjects
10018 Ophthalmology Clinic, 2019-20 coronavirus outbreak, medicine.medical_specialty, Visual acuity, genetic structures, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), AMD, COVID-19, SARS-CoV-2, neovascular age related macular degeneration, 610 Medicine & health, 2700 General Medicine, Article, 03 medical and health sciences, 0302 clinical medicine, Ophthalmology, Age related, Medicine, In patient, business.industry, General Medicine, Macular degeneration, medicine.disease, eye diseases, Multicenter study, 030221 ophthalmology & optometry, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

This is a retrospective, multicenter study of consecutive patients with nAMD scheduled for a visit and/or a treatment with an intravitreal injection (IVI) during the 3 months before lockdown in the Ophthalmology Departments of six centers of Europe.The study was conducted on 546 patients, of which 55.13% were females, almost 100% of the patients were White/Caucasian race, and 71.53% of the patients presented a type 1 macular neovascularization (NVM). A total of 62.82% of patients (343 patients) that were on scheduled clinic visits and/or intravitreal injection treatment during the 3 months before the quarantine did not attend either to visit or for treatment during the lockdown. The mean number of injections during the lockdown was significantly reduced. This was followed by a significant reduction in the mean best-corrected visual acuity (BCVA) between the 3 months before the lockdown (mean BCVA of 60.68 ± 19.77 letters) and 6 months after lockdown (mean BCVA of 56.98 ± 22.59 letters). Patients with better BCVA before the lockdown and the ones showing neovascular activity were more likely to attend their scheduled visits and/or IVI treatments. The COVID-19 pandemic and the lockdown have led to a decrease in the number of IVI treatments in patients with nAMD, evidencing a significant vision loss at 6 months.

Published
2021

48. Early impact of COVID-19 outbreak on eye care: Insights from EUROCOVCAT group

Author

Tomasz Chorągiewicz, Chiara Posarelli, Miguel A. Teus, Riikka Törnblom, Ozlem Evren Kemer, Boris Malyugin, Michael A. Burdon, Robert Rejdak, Daniele Tognetto, Antoine P. Brézin, Arthur B. Cummings, Mario Damiano Toro, Isabel Prieto, Toro, M. D., Brezin, A. P., Burdon, M., Cummings, A. B., Evren Kemer, O., Malyugin, B. E., Prieto, I., Teus, M. A., Tognetto, D., Tornblom, R., Posarelli, C., Choragiewicz, T., and Rejdak, R.

Subjects
medicine.medical_specialty, Infectious Disease Transmission, Patient-to-Professional, Eye Diseases, Infectious Disease Transmission, COVID-19 pandemic, cornea transplantation, Global Health, Disease Outbreaks, irreversible blindness, Patient-to-Professional, Hospital, Pandemic, Health care, medicine, Global health, Humans, Intensive care medicine, Human resources, retinal detachment surgery, Emergency Service, Disease Outbreak, cataract surgery, glaucoma, intravitreal injection, ophthalmology, COVID-19, Delivery of Health Care, Emergency Service, Hospital, SARS-CoV-2, business.industry, Transmission (medicine), Public health, Outbreak, Eye Disease, General Medicine, irreversible blindne, business, Elective Surgical Procedure, Human
Abstract

The recent outbreak of coronavirus disease 2019 (COVID-19) has been declared a public health emergency worldwide. The scientific community has put in much effort and published studies that described COVID-19’s biology, transmission, clinical diagnosis, candidate therapeutics, and vaccines. However, to date, only a few data are available on the impact of COVID-19 pandemic on ophthalmological care in different health care systems, its future consequences in terms of disability, and access to sight-saving cures for many patients. To reduce human-to-human transmission of the virus and also ensure supply of infrastructures, human resources, and disposable medical devices to many regions, it is crucial to assess risks and postpone non-essential outpatient visits and elective surgical procedures, especially in older patients and those with comorbidities. This delay or suspension in essential eye procedures may cause significant and rapid vision impairment to irreversible blindness. Determining the risk-benefit profile of treating these ocular pathologies is a public health issue of supreme priority, even though many patients benefiting from therapeutic treatments are elderly, who are more vulnerable to COVID-19. If not reversible, this process could lead to a dramatic increase in disability and unsustainable social costs for many Governments.

Published
2021

49. Rethinking Elective Cataract Surgery Diagnostics, Assessments, and Tools after the COVID-19 Pandemic Experience and Beyond: Insights from the EUROCOVCAT Group

Author

Arthur B. Cummings, Antoine P. Brézin, Miguel A. Teus, Rosa Giglio, Mario Damiano Toro, Daniele Tognetto, Boris Malyugin, Isabel Prieto, Alex Lucia Vinciguerra, Robert Rejdak, Chiara De Giacinto, Ozlem Evren Kemer, Riikka Törnblom, Tognetto, Daniele, Brézin, Antoine P, Cummings, Arthur B, Malyugin, Boris E, Evren Kemer, Ozlem, Prieto, Isabel, Rejdak, Robert, Teus, Miguel A, Törnblom, Riikka, Toro, Mario D, Vinciguerra, Alex L, Giglio, Rosa, De Giacinto, Chiara, Tognetto, D., Brezin, A. P., Cummings, A. B., Malyugin, B. E., Kemer, O. E., Prieto, I., Rejdak, R., Teus, M. A., Tornblom, R., Toro, M. D., Vinciguerra, A. L., Giglio, R., and de Giacinto, C.

Subjects
Telemedicine, COVID-19 outbreak, genetic structures, medicine.medical_treatment, Clinical Biochemistry, Disease, Review, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Pandemic, Health care, medicine, 030212 general & internal medicine, lcsh:R5-920, business.industry, Phacoemulsification, Perioperative, cataract surgery, Cataract surgery, medicine.disease, eye diseases, phacoemulsification, 030221 ophthalmology & optometry, Medical emergency, business, lcsh:Medicine (General)
Abstract

The progressive deterioration of the visual function in patients on waiting lists for cataract surgery has a negative impact on their quality of life, especially in the elderly population. Patient waiting times for cataract surgeries in many healthcare settings have increased recently due to the prolonged stop or slowdown of elective cataract surgery as a result of coronavirus disease 19 (COVID-19). The aim of this review is to highlight the impact of such a “de-prioritization” of cataract surgery and to summarize some critical issues and useful hints on how to reorganize cataract pathways, with a special focus on perioperative diagnostic tools during the recovery phase and beyond. The experiences of a group of surgeons originating from nine different countries, named the European COVID-19 Cataract Group (EUROCOVCAT), have been combined with the literature and recommendations from scientific ophthalmic societies and healthcare institutions. Key considerations for elective cataract surgery should include the reduction of the number of unnecessary visits and examinations, adoption of precautionary measures, and implementation of telemedicine instruments. New strategies should be adopted to provide an adequate level of assistance and to guarantee safety conditions. Flexibility will be the watchword and regular updates would be necessary following scientific insights and the development of the pandemic.

Published
2020

50. Comparative analysis of 23-, 25-, and 27-gauge forceps stiffness and related displacement

Author

Gianluca Turco, Gabriella Cirigliano, Chiara De Giacinto, Daniele Tognetto, Marco R Pastore, Massimo Borelli, Pastore, M. R., De Giacinto, C., Cirigliano, G., Turco, G., Borelli, M., and Tognetto, D.

Subjects
0301 basic medicine, Microsurgery, Materials science, Forceps, Retina, vitreous, 03 medical and health sciences, retinal detachment, 0302 clinical medicine, Vitrectomy, medicine, Humans, Displacement (orthopedic surgery), Retrospective Studies, pars plana vitrectomy, Deformation (mechanics), business.industry, epiretinal membrane, Stiffness, General Medicine, Structural engineering, Gauge (firearms), Surgical Instruments, Ophthalmology, 030104 developmental biology, 030221 ophthalmology & optometry, medicine.symptom, business
Abstract

Purpose To test the stiffness and displacement of different vitreous forceps. Physical features and deformation after multiple procedures were also measured. Methods Eleven different 23-, 25-, and 27-gauge vitreous forceps were studied. The measurements were repeated loading the probe at different distances from the tip: at the top of the tip and 10 and 20 mm from the tip, respectively. For each probe, 10 successive identical bending tests were performed. The total length and the internal and external diameters of each forceps were also measured. Results A total of 330 successive identical bending tests were performed. No progression in deformation after the repeated measurements was recorded ( p > 0.05). In each gauge group, displacement differences were detected according to the manufacturing metal properties, the total length, and the thickness of the shaft wall. A minimal adequate model to describes forceps displacements in terms of their significant predictors, such as gauge, model, and load distance from the tip, was created. Conclusion We provided a precise assessment of the stiffness and displacement of different vitreous forceps to enable surgeons to select the optimal instrument according to the benefits and limitations of each forceps.

Published
2020

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