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4. International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19

Author

Börger, Verena, Weiss, Daniel J, Anderson, Johnathon D, Borràs, Francesc E, Bussolati, Benedetta, Carter, David RF, Dominici, Massimo, Falcón-Pérez, Juan M, Gimona, Mario, Hill, Andrew F, Hoffman, Andrew M, de Kleijn, Dominique, Levine, Bruce L, Lim, Rebecca, Lötvall, Jan, Mitsialis, S Alex, Monguió-Tortajada, Marta, Muraca, Maurizio, Nieuwland, Rienk, Nowocin, Anna, O'Driscoll, Lorraine, Ortiz, Luis A, Phinney, Donald G, Reischl, Ilona, Rohde, Eva, Sanzenbacher, Ralf, Théry, Clotilde, Toh, Wei Seong, Witwer, Kenneth W, Lim, Sai Kiang, and Giebel, Bernd

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Regenerative Medicine, 5.2 Cellular and gene therapies, Development of treatments and therapeutic interventions, Generic health relevance, Good Health and Well Being, Coronavirus Infections, Exosomes, Extracellular Vesicles, Humans, Mesenchymal Stem Cells, Societies, Scientific, COVID-19 Drug Treatment, Clinical Sciences, Immunology, Medical biotechnology
Abstract

StatementThe International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular vesicles (EVs, including exosomes) from mesenchymal stromal cells (MSCs) and possibly other cell sources as treatments for COVID-19. Research and trials in this area are encouraged. However, ISEV and ISCT do not currently endorse the use of EVs or exosomes for any purpose in COVID-19, including but not limited to reducing cytokine storm, exerting regenerative effects or delivering drugs, pending the generation of appropriate manufacturing and quality control provisions, pre-clinical safety and efficacy data, rational clinical trial design and proper regulatory oversight.

Published
2020

5. Mesenchymal Stem Cell Exosomes Enhance Posterolateral Spinal Fusion in a Rat Model.

Author

Lam, Wing Moon Raymond, Zhuo, Wen-Hai, Yang, Long, Tan, Rachel, Lim, Sai Kiang, Hey, Hwee Weng Dennis, and Toh, Wei Seong

Subjects
SPINAL fusion, CARTILAGE regeneration, BONE morphogenetic proteins, ANIMAL disease models, BONE mechanics, EXTRACELLULAR vesicles, MESENCHYMAL stem cells, EXOSOMES, BONE growth
Abstract

Spinal fusion, a common surgery performed for degenerative lumbar conditions, often uses recombinant human bone morphogenetic protein 2 (rhBMP-2) that is associated with adverse effects. Mesenchymal stromal/stem cells (MSCs) and their extracellular vesicles (EVs), particularly exosomes, have demonstrated efficacy in bone and cartilage repair. However, the efficacy of MSC exosomes in spinal fusion remains to be ascertained. This study investigates the fusion efficacy of MSC exosomes delivered via an absorbable collagen sponge packed in a poly Ɛ-caprolactone tricalcium phosphate (PCL–TCP) scaffold in a rat posterolateral spinal fusion model. Herein, it is shown that a single implantation of exosome-supplemented collagen sponge packed in PCL–TCP scaffold enhanced spinal fusion and improved mechanical stability by inducing bone formation and bridging between the transverse processes, as evidenced by significant improvements in fusion score and rate, bone structural parameters, histology, stiffness, and range of motion. This study demonstrates for the first time that MSC exosomes promote bone formation to enhance spinal fusion and mechanical stability in a rat model, supporting its translational potential for application in spinal fusion. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Extracellular Vesicles and Their Mimetics: A Comparative Study of Their Pharmacological Activities and Immunogenicity Profiles

Author

Chng, Wei Heng, primary, Muthuramalingam, Ram Pravin Kumar, additional, Lou, Charles Kang Liang, additional, New, Silas, additional, Neupane, Yub Raj, additional, Lee, Choon Keong, additional, Altay Benetti, Ayca, additional, Huang, Chenyuan, additional, Thoniyot, Praveen, additional, Toh, Wei Seong, additional, Wang, Jiong-Wei, additional, and Pastorin, Giorgia, additional

Published
2023
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19. A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, “Therapeutic advances with native and engineered human extracellular vesicles”

Author

Toh, Wei Seong, primary, Yarani, Reza, additional, El Andaloussi, Samir, additional, Cho, Byong Seung, additional, Choi, Chulhee, additional, Corteling, Randolph, additional, De Fougerolles, Antonin, additional, Gimona, Mario, additional, Herz, Josephine, additional, Khoury, Maroun, additional, Robbins, Paul D., additional, Williams, Douglas, additional, Weiss, Daniel J., additional, Rohde, Eva, additional, Giebel, Bernd, additional, and Lim, Sai Kiang, additional

Published
2023
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23. Perinatal derivatives: How to best validate their immunomodulatory functions

Author

Papait, Andrea, primary, Silini, Antonietta Rosa, additional, Gazouli, Maria, additional, Malvicini, Ricardo, additional, Muraca, Maurizio, additional, O’Driscoll, Lorraine, additional, Pacienza, Natalia, additional, Toh, Wei Seong, additional, Yannarelli, Gustavo, additional, Ponsaerts, Peter, additional, Parolini, Ornella, additional, Eissner, Günther, additional, Pozzobon, Michela, additional, Lim, Sai Kiang, additional, and Giebel, Bernd, additional

Published
2022
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24. Mesenchymal stromal cell-derived small extracellular vesicles modulate macrophage polarization and enhance angio-osteogenesis to promote bone healing

Author

Chuah, Shang Jiunn, primary, Yong, Chee Weng, additional, Teo, Kristeen Ye Wen, additional, Chew, Jacob Ren Jie, additional, Cheow, Yi Ann, additional, Zhang, Shipin, additional, Wong, Raymond Chung Wen, additional, Lim, Asher Ah Tong, additional, Lim, Sai Kiang, additional, and Toh, Wei Seong, additional

Published
2022
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29. sj-pdf-1-ajs-10.1177_03635465211068129 ��� Supplemental material for Mesenchymal Stem Cell Exosomes Promote Functional Osteochondral Repair in a Clinically Relevant Porcine Model

Author

Zhang, Shipin, Wong, Keng Lin, Ren, Xiafei, Teo, Kristeen Ye Wen, Afizah, Hassan, Choo, Andre Boon Hwa, Lai, Ruenn Chai, Lim, Sai Kiang, Hui, James Hoi Po, and Toh, Wei Seong

Subjects
FOS: Clinical medicine, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-ajs-10.1177_03635465211068129 for Mesenchymal Stem Cell Exosomes Promote Functional Osteochondral Repair in a Clinically Relevant Porcine Model by Shipin Zhang, Keng Lin Wong, Xiafei Ren, Kristeen Ye Wen Teo, Hassan Afizah, Andre Boon Hwa Choo, Ruenn Chai Lai, Sai Kiang Lim, James Hoi Po Hui and Wei Seong Toh in The American Journal of Sports Medicine

Published
2022
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41. Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles

Author

Gimona, Mario, primary, Brizzi, Maria Felice, additional, Choo, Andre Boon Hwa, additional, Dominici, Massimo, additional, Davidson, Sean M., additional, Grillari, Johannes, additional, Hermann, Dirk M., additional, Hill, Andrew F., additional, de Kleijn, Dominique, additional, Lai, Ruenn Chai, additional, Lai, Charles P., additional, Lim, Rebecca, additional, Monguió-Tortajada, Marta, additional, Muraca, Maurizio, additional, Ochiya, Takahiro, additional, Ortiz, Luis A., additional, Toh, Wei Seong, additional, Yi, Yong Weon, additional, Witwer, Kenneth W., additional, Giebel, Bernd, additional, and Lim, Sai Kiang, additional

Published
2021
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42. sj-pdf-1-ajs-10.1177_0363546520981704 ��� Supplemental material for Intra-articular Injections of Mesenchymal Stem Cells Without Adjuvant Therapies for Knee Osteoarthritis: A Systematic Review and Meta-analysis

Author

Tan, Si Heng Sharon, Kwan, Yiu Tsun, Neo, Wei Jian, Chong, Jia Yan, Kuek, Tze Yin Joshua, See, Jun Ze Fabian, Wong, Keng Lin, Toh, Wei Seong, and Hui, James Hoi Po

Subjects
FOS: Clinical medicine, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, humanities, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-ajs-10.1177_0363546520981704 for Intra-articular Injections of Mesenchymal Stem Cells Without Adjuvant Therapies for Knee Osteoarthritis: A Systematic Review and Meta-analysis by Si Heng Sharon Tan, Yiu Tsun Kwan, Wei Jian Neo, Jia Yan Chong, Tze Yin Joshua Kuek, Jun Ze Fabian See, Keng Lin Wong, Wei Seong Toh and James Hoi Po Hui in The American Journal of Sports Medicine

Published
2021
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43. sj-pdf-1-car-10.1177_19476035211029707 – Supplemental material for Mesenchymal Stem Cell Extracellular Vesicles as Adjuvant to Bone Marrow Stimulation in Chondral Defect Repair in a Minipig Model

Author

Hede, Kris T. C., Christensen, Bjørn B., Olesen, Morten L., Thomsen, Jesper Skovhus, Foldager, Casper B., Toh, Wei Seong, Lim, Sai Kiang, and Lind, Martin C.

Subjects
FOS: Clinical medicine, FOS: Biological sciences, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, 69999 Biological Sciences not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-car-10.1177_19476035211029707 for Mesenchymal Stem Cell Extracellular Vesicles as Adjuvant to Bone Marrow Stimulation in Chondral Defect Repair in a Minipig Model by Kris T. C. Hede, Bjørn B. Christensen, Morten L. Olesen, Jesper Skovhus Thomsen, Casper B. Foldager, Wei Seong Toh, Sai Kiang Lim and Martin C. Lind in CARTILAGE

Published
2021
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44. sj-pdf-2-car-10.1177_19476035211029707 – Supplemental material for Mesenchymal Stem Cell Extracellular Vesicles as Adjuvant to Bone Marrow Stimulation in Chondral Defect Repair in a Minipig Model

Author

Hede, Kris T. C., Christensen, Bjørn B., Olesen, Morten L., Thomsen, Jesper Skovhus, Foldager, Casper B., Toh, Wei Seong, Lim, Sai Kiang, and Lind, Martin C.

Subjects
FOS: Clinical medicine, FOS: Biological sciences, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, 69999 Biological Sciences not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-2-car-10.1177_19476035211029707 for Mesenchymal Stem Cell Extracellular Vesicles as Adjuvant to Bone Marrow Stimulation in Chondral Defect Repair in a Minipig Model by Kris T. C. Hede, Bjørn B. Christensen, Morten L. Olesen, Jesper Skovhus Thomsen, Casper B. Foldager, Wei Seong Toh, Sai Kiang Lim and Martin C. Lind in CARTILAGE

Published
2021
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