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2. Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer

Author

Takatsu, Fumiaki, Suzawa, Ken, Tomida, Shuta, Thu, Yin Min, Sakaguchi, Masakiyo, Toji, Tomohiro, Ohki, Masayoshi, Tsudaka, Shimpei, Date, Keiichi, Matsuda, Naoki, Iwata, Kazuma, Zhu, Yidan, Nakata, Kentaro, Shien, Kazuhiko, Yamamoto, Hiromasa, Nakayama, Akiko, Okazaki, Mikio, Sugimoto, Seiichiro, and Toyooka, Shinichi

Published
2023
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4. ASO Visual Abstract: Prognostic Impact of Tumor-Infiltrating Lymphocytes, Tertiary Lymphoid Structures, and Neutrophil-to-Lymphocyte Ratio in Pulmonary Metastases from Uterine Leiomyosarcoma

Author

Matsuda, Naoki, Yamamoto, Hiromasa, Habu, Tomohiro, Iwata, Kazuma, Matsubara, Kei, Tanaka, Shin, Hashimoto, Kohei, Shien, Kazuhiko, Suzawa, Ken, Miyoshi, Kentaroh, Toji, Tomohiro, Okazaki, Mikio, Sugimoto, Seiichiro, Takahashi, Katsuhito, and Toyooka, Shinichi

Published
2023
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5. Correction to: Periostin secreted by cancer‑associated fibroblasts promotes cancer progression and drug resistance in non‑small cell lung cancer

Author

Takatsu, Fumiaki, Suzawa, Ken, Tomida, Shuta, Thu, Yin Min, Sakaguchi, Masakiyo, Toji, Tomohiro, Ohki, Masayoshi, Tsudaka, Shimpei, Date, Keiichi, Matsuda, Naoki, Iwata, Kazuma, Zhu, Yidan, Nakata, Kentaro, Shien, Kazuhiko, Yamamoto, Hiromasa, Nakayama, Akiko, Okazaki, Mikio, Sugimoto, Seiichiro, and Toyooka, Shinichi

Published
2024
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6. Regulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma

Author

Konishi, Daisuke, Umeda, Yuzo, Yoshida, Kazuhiro, Shigeyasu, Kunitoshi, Yano, Shuya, Toji, Tomohiro, Takeda, Sho, Yoshida, Ryuichi, Yasui, Kazuya, Fuji, Tomokazu, Matsumoto, Kazuyuki, Kishimoto, Hiroyuki, Michiue, Hiroyuki, Teraishi, Fuminori, Kato, Hironari, Tazawa, Hiroshi, Yanai, Hiroyuki, Yagi, Takahito, Goel, Ajay, and Fujiwara, Toshiyoshi

Published
2022
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9. PD-L1 expression in tongue squamous cell carcinoma

Author

Akisada, Naoki, Nishimoto, Kohei, Takao, Soshi, Gion, Yuka, Marunaka, Hidenori, Tachibana, Tomoyasu, Makino, Takuma, Miki, Kentaro, Akagi, Yusuke, Tsumura, Munechika, Toji, Tomohiro, Yoshino, Tadashi, Nishizaki, Kazunori, Orita, Yorihisa, and Sato, Yasuharu

Published
2021
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11. Correction to: Periostin secreted by cancer‑associated fibroblasts promotes cancer progression and drug resistance in non‑small cell lung cancer

Author

Takatsu, Fumiaki, primary, Suzawa, Ken, additional, Tomida, Shuta, additional, Thu, Yin Min, additional, Sakaguchi, Masakiyo, additional, Toji, Tomohiro, additional, Ohki, Masayoshi, additional, Tsudaka, Shimpei, additional, Date, Keiichi, additional, Matsuda, Naoki, additional, Iwata, Kazuma, additional, Zhu, Yidan, additional, Nakata, Kentaro, additional, Shien, Kazuhiko, additional, Yamamoto, Hiromasa, additional, Nakayama, Akiko, additional, Okazaki, Mikio, additional, Sugimoto, Seiichiro, additional, and Toyooka, Shinichi, additional

Published
2023
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16. Sequential Combination of FLAM and Venetoclax plus Azacitidine to Bridge to Cord Blood Transplantation in a Patient with Primary Induction Failure Acute Myeloid Leukemia

Author

Murakami, Hiroyuki, primary, Matsuoka, Ken-ichi, additional, Asano, Takeru, additional, Moriyama, Takashi, additional, Matsumura, Akifumi, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Fujii, Keiko, additional, Fujii, Nobuharu, additional, Toji, Tomohiro, additional, Yoshino, Tadashi, additional, and Maeda, Yoshinobu, additional

Published
2022
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18. Lung recruitment after cardiac arrest during procurement of atelectatic donor lungs is a protective measure in lung transplantation

Author

Niman, Eito, Miyoshi, Kentaroh, Shiotani, Toshio, Toji, Tomohiro, Igawa, Takuro, Otani, Shinji, Okazaki, Mikio, Sugimoto, Seiichiro, Yamane, Masaomi, Toyooka, Shinichi, Niman, Eito, Miyoshi, Kentaroh, Shiotani, Toshio, Toji, Tomohiro, Igawa, Takuro, Otani, Shinji, Okazaki, Mikio, Sugimoto, Seiichiro, Yamane, Masaomi, and Toyooka, Shinichi

Abstract

Background: Brain-dead donors are susceptible to pulmonary atelectasis (AT). In procurement surgery, lung recruitment under circulatory conditions and cold-flushing for atelectatic donor lungs often provoke graft injury due to the acute blood inflow. We hypothesized that lung recruitment without blood circulation can mitigate graft injury. This study aimed to examine the benefits of lung recruitment subsequent to cardiac arrest using a porcine lung-transplant model. Methods: Thirteen donor pigs were categorized into the non-atelectatic (No-AT) group (n=3) representing a healthy control group; AT-BCR group (n=5), in which AT was reverted by conventional blood-circulated recruitment (BCR); and AT-no-BCR group (n=5), in which AT was reverted by no-BCR following circulatory arrest. In the atelectatic donor models, the left main bronchus was ligated for 24 hours prior to lung procurement. Left lung transplantation (LTx) was subsequently performed in the thirteen recipient pigs. After 6 hours evaluation, the recipients were euthanized and the lung grafts were excised. Results: The post-transplant PaO2/FiO(2) ratio was significantly higher in the AT-no-BCR group than in the AT-BCR group (P=0.015). Wet/dry ratio, histological findings of graft injury and tissue interleukin-8 expression in the AT-no-BCR group were similar to those of the No-AlT group. Conclusions: Lung recruitment without circulation after circulatory arrest could be more protective for atelectatic donor lung than the conventional procedure.

Published
2022

19. Sequential Combination of FLAM and Venetoclax plus Azacitidine to Bridge to Cord Blood Transplantation in a Patient with Primary Induction Failure Acute Myeloid Leukemia

Author

Murakami, Hiroyuki, Matsuoka, Ken-Ichi, Asano, Takeru, Moriyama, Takashi, Matsumura, Akifumi, Fujiwara, Hideaki, Asada, Noboru, Ennishi, Daisuke, Nishimori, Hisakazu, Fujii, Keiko, Fujii, Nobuharu, Toji, Tomohiro, Yoshino, Tadashi, Maeda, Yoshinobu, Murakami, Hiroyuki, Matsuoka, Ken-Ichi, Asano, Takeru, Moriyama, Takashi, Matsumura, Akifumi, Fujiwara, Hideaki, Asada, Noboru, Ennishi, Daisuke, Nishimori, Hisakazu, Fujii, Keiko, Fujii, Nobuharu, Toji, Tomohiro, Yoshino, Tadashi, and Maeda, Yoshinobu

Abstract

Venetoclax (VEN) is an oral B-cell lymphoma-2 (BCL-2) inhibitor that has been widely used to treat various hematological disorders. Recent studies have demonstrated that VEN in combination with fludarabine-enhanced high-dose cytarabine (FLA) is effective for treating relapsed or refractory acute myeloid leukemia (AML). In the combination therapy, salvage chemotherapy and VEN are basically concurrently administrated; however, further optimization may enable the treatment to apply to larger numbers of patients with various clinical backgrounds. Here, we describe a case of refractory AML treated with a sequential combination of the intensive chemotherapy (fludarabine, cytarabine, and mitoxantrone; FLAM) and VEN/AZA to bridge to an unrelated cord blood transplantation (uCBT). By continuously adding VEN/AZA after FLAM, the patient achieved morphologic leukemia free state with only minor toxicities. Blood cell counts did not recover until the time of transplantation because of the deep myelosuppression caused by the treatment sequence, but the infection risk was safely managed during this period. After engraftment, maintenance therapy with VEN/AZA was performed, and the patient has survived without disease recurrence for over 9 months after transplantation. Our case suggests that bridging therapy with VEN and AZA from the time of the last chemotherapy to allogeneic transplantation may provide an effective and tolerable treatment strategy for refractory AML. Further studies of larger numbers of cases are needed to validate the effectiveness of this treatment.

Published
2022

21. Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy

Author

Kiso, Sayaka, primary, Sugiura, Hiroyuki, additional, Kuroi, Taiga, additional, Omote, Rika, additional, Toji, Tomohiro, additional, Ishikawa, Tatsunori, additional, Okamoto, Sachiyo, additional, Nomura, Naho, additional, Masunari, Taro, additional, Sezaki, Nobuo, additional, Kiguchi, Toru, additional, and Tanimoto, Mitsune, additional

Published
2021
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24. Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer

Author

Matsueda, Katsunori, primary, Kanzaki, Hiromitsu, additional, Takenaka, Ryuta, additional, Nakagawa, Masahiro, additional, Matsueda, Kazuhiro, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, Toji, Tomohiro, additional, Tanaka, Takehiro, additional, Yagi, Takahito, additional, Fujiwara, Toshiyoshi, additional, and Okada, Hiroyuki, additional

Published
2021
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25. Lymphoepithelial Carcinoma in the Lateral Tongue: The Case Report

Author

Ono, Sawako, primary, Marunaka, Hidenori, additional, Yanai, Hiroyuki, additional, Kawai, Hotaka, additional, Takabatake, Kiyofumi, additional, Nishida, Kenji, additional, Toji, Tomohiro, additional, Nakano, Keisuke, additional, Nagatsuka, Hitoshi, additional, and Yoshino, Tadashi, additional

Published
2021
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26. Pathological and clinical effects of interleukin-6 on human myocarditis

Author

Amioka, Naofumi, primary, Nakamura, Kazufumi, additional, Kimura, Tomonari, additional, Ohta-Ogo, Keiko, additional, Tanaka, Takehiro, additional, Toji, Tomohiro, additional, Akagi, Satoshi, additional, Nakagawa, Koji, additional, Toh, Norihisa, additional, Yoshida, Masashi, additional, Miyoshi, Toru, additional, Nishii, Nobuhiro, additional, Watanabe, Atsuyuki, additional, Asano, Ryotaro, additional, Ogo, Takeshi, additional, Nakaoka, Yoshikazu, additional, Morita, Hiroshi, additional, Yanai, Hiroyuki, additional, and Ito, Hiroshi, additional

Published
2021
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27. Donor Treg expansion by liposomal α‐galactosylceramide modulates Tfh cells and prevents sclerodermatous chronic graft‐versus‐host disease

Author

Sugiura, Hiroyuki, primary, Matsuoka, Ken‐ichi, additional, Fukumi, Takuya, additional, Sumii, Yuichi, additional, Kondo, Takumi, additional, Ikegawa, Shuntaro, additional, Meguri, Yusuke, additional, Iwamoto, Miki, additional, Sando, Yasuhisa, additional, Nakamura, Makoto, additional, Toji, Tomohiro, additional, Ishii, Yasuyuki, additional, and Maeda, Yoshinobu, additional

Published
2021
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28. Donor Treg expansion by liposomal alpha-galactosylceramide modulates Tfh cells and prevents sclerodermatous chronic graft-versus-host disease

Author

Sugiura, Hiroyuki, Matsuoka, Ken-Ichi, Fukumi, Takuya, Sumii, Yuichi, Kondo, Takumi, Ikegawa, Shuntaro, Meguri, Yusuke, Iwamoto, Miki, Sando, Yasuhisa, Nakamura, Makoto, Toji, Tomohiro, Ishii, Yasuyuki, Maeda, Yoshinobu, Sugiura, Hiroyuki, Matsuoka, Ken-Ichi, Fukumi, Takuya, Sumii, Yuichi, Kondo, Takumi, Ikegawa, Shuntaro, Meguri, Yusuke, Iwamoto, Miki, Sando, Yasuhisa, Nakamura, Makoto, Toji, Tomohiro, Ishii, Yasuyuki, and Maeda, Yoshinobu

Abstract

Background and Aim: Chronic graft-versus-host disease (cGVHD) is a major cause of nonrelapse morbidity and mortality following hematopoietic stem cell transplantation (HSCT). alpha-Galactosylceramide (alpha-GC) is a synthetic glycolipid that is recognized by the invariant T-cell receptor of invariant natural killer T (iNKT) cells in a CD1d-restricted manner. Stimulation of iNKT cells by alpha-GC leads to the production of not only immune-stimulatory cytokines but also immune-regulatory cytokines followed by regulatory T-cell (Treg) expansion in vivo. Methods: We investigated the effect of iNKT stimulation by liposomal alpha-GC just after transplant on the subsequent immune reconstitution and the development of sclerodermatous cGVHD. Results: Our study showed that multiple administrations of liposomal alpha-GC modulated both host- and donor-derived iNKT cell homeostasis and induced an early expansion of donor Tregs. We also demonstrated that the immune modulation of the acute phase was followed by the decreased levels of CXCL13 in plasma and follicular helper T cells in lymph nodes, which inhibited germinal center formation, resulting in the efficient prevention of sclerodermatous cGVHD. Conclusions: These data demonstrated an important coordination of T- and B-cell immunity in the pathogenesis of cGVHD and may provide a novel clinical strategy for the induction of immune tolerance after allogeneic HSCT.

Published
2021

29. A Case Report of Spindle Cell Carcinoma with Osteoid and Cartilage Formation in the Tongue

Author

Ono, Sawako, Makino, Takuma, Yanai, Hiroyuki, Kawai, Hotaka, Takabatake, Kiyofumi, Nakano, Keisuke, Nishida, Kenji, Taniguchi, Kohei, Toji, Tomohiro, Nagatsuka, Hitoshi, Yoshino, Tadashi, Ono, Sawako, Makino, Takuma, Yanai, Hiroyuki, Kawai, Hotaka, Takabatake, Kiyofumi, Nakano, Keisuke, Nishida, Kenji, Taniguchi, Kohei, Toji, Tomohiro, Nagatsuka, Hitoshi, and Yoshino, Tadashi

Abstract

Spindle cell carcinoma (SCSCC) with osteoid and/or cartilage formation in the head and neck is rare; only one case was reported in the tongue. Herein, we report an SCSCC with osteoid and cartilage formation of the tongue developed in an 85-year-old man, and then review the report.

Published
2021

30. Lymphoepithelial Carcinoma in the Lateral Tongue: The Case Report

Author

Ono, Sawako, Marunaka, Hidenori, Yanai, Hiroyuki, Kawai, Hotaka, Takabatake, Kiyofumi, Nishida, Kenji, Toji, Tomohiro, Nakano, Keisuke, Nagatsuka, Hitoshi, Yoshino, Tadashi, Ono, Sawako, Marunaka, Hidenori, Yanai, Hiroyuki, Kawai, Hotaka, Takabatake, Kiyofumi, Nishida, Kenji, Toji, Tomohiro, Nakano, Keisuke, Nagatsuka, Hitoshi, and Yoshino, Tadashi

Abstract

Lymphoepithelial carcinoma (LEC) of the tongue is a rare subtype of squamous cell carcinoma. Histologically, it is an undifferentiated carcinoma with rich lymphocyte and plasma cell infiltration. The most common location for LEC in the head and neck is the salivary glands, and LEC of the oral cavity is extremely rare. The second case report of LEC in the lateral tongue is presented. In addition, a review of the literature was performed, and the relationship between LEC and Epstein-Barr virus infection was considered.

Published
2021

31. Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer

Author

Matsueda, Katsunori, Kanzaki, Hiromitsu, Takenaka, Ryuta, Nakagawa, Masahiro, Matsueda, Kazuhiro, Iwamuro, Masaya, Kawano, Seiji, Kawahara, Yoshiro, Toji, Tomohiro, Tanaka, Takehiro, Yagi, Takahito, Fujiwara, Toshiyoshi, Okada, Hiroyuki, Matsueda, Katsunori, Kanzaki, Hiromitsu, Takenaka, Ryuta, Nakagawa, Masahiro, Matsueda, Kazuhiro, Iwamuro, Masaya, Kawano, Seiji, Kawahara, Yoshiro, Toji, Tomohiro, Tanaka, Takehiro, Yagi, Takahito, Fujiwara, Toshiyoshi, and Okada, Hiroyuki

Abstract

Objective The rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma (Ad-Ca). Materials We retrospectively analyzed 165 patients with sporadic non-ampullary duodenal carcinomas (SNADCs) from four institutions between January 2003 and December 2018. The SNADCs were divided to three groups according to histological diagnosis: SM-Ca, M-Ca, and Ad-Ca. The clinicopathological characteristics and mucin phenotypes were compared between groups. Results Among the 165 SNADCs, 11 (7%) were classified as SM-Ca, 70 (42%) as M-Ca, and 84 (51%) as Ad-Ca. We found that all SM-Ca (P = 0.013) and most Ad-Ca (P = 0.020) lesions were located on the oral-Vater; however, an almost equal distribution of M-Ca lesions was found between the oral- and anal-Vater. No significant difference was observed between the tumor diameter of M-Ca and SM-Ca; however, 45% (5/11) of SM-Ca were <= 10 mm. A total of 73% (8/11) of SM-Ca were classified as gastric phenotype and no lesions were classified as intestinal phenotype; whereas most M-Ca were classified as intestinal phenotype (67%, 8/12). Conclusions SM-Ca lesions were all located on the oral-Vater and were highly associated with the gastric mucin phenotype, which were different from the features of most M-Ca.

Published
2021

33. Appendiceal Orifice Inflammation in Ulcerative Colitis Mimicking Mucosa-Associated Lymphoid Tissue Lymphoma in the Cecum

Author

Iwamuro, Masaya, Takahashi, Takahide, Tanaka, Takehiro, Toji, Tomohiro, Hiraoka, Sakiko, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Subjects
Article Subject, immune system diseases, hemic and lymphatic diseases, digestive system diseases
Abstract

A 55-year-old Japanese woman, who had been diagnosed with ulcerative colitis at 18 years of age, underwent screening endoscopy examinations. Esophagogastroduodenoscopy revealed an extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the stomach. Colonoscopy showed a slightly elevated reddish lesion with dilated microvessels but no erosions or ulcers. Although MALT lymphoma in the cecum was endoscopically suspected, flow cytometry and pathological analyses led to the diagnosis of appendiceal orifice inflammation in ulcerative colitis. This case highlights the diversity of the endoscopic appearance of appendiceal orifice inflammation in ulcerative colitis.

Published
2020
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34. Secondary Pulmonary Alveolar Proteinosis Associated with Primary Myelofibrosis and Ruxolitinib Treatment: An Autopsy Case

Author

Sugiura, Hiroyuki, Nishimori, Hisakazu, Nishii, Kazuya, Toji, Tomohiro, Fujii, Keiko, Fujii, Nobuharu, Matsuoka, Ken-ichi, Nakata, Koh, Kiura, Katsuyuki, Maeda, Yoshinobu, Sugiura, Hiroyuki, Nishimori, Hisakazu, Nishii, Kazuya, Toji, Tomohiro, Fujii, Keiko, Fujii, Nobuharu, Matsuoka, Ken-ichi, Nakata, Koh, Kiura, Katsuyuki, and Maeda, Yoshinobu

Abstract

Pulmonary alveolar proteinosis (PAP) is an uncommon lung disorder characterized by the excessive accumulation of surfactant-derived lipoproteins in the pulmonary alveoli and terminal bronchiole. Secondary PAP associated with primary myelofibrosis (PMF) is extremely rare, and to our knowledge, no autopsy case has been reported. We herein report an autopsy case of secondary PAP occurring in a patient with PMF who was treated with the Janus kinase 1/2 inhibitor ruxolitinib. We confirmed a diagnosis of PAP with complications based on the pathological findings at the autopsy. Notably, this case might suggest an association between ruxolitinib treatment and PAP occurrence.

Published
2020

35. Spinal Cord Diffuse Midline Glioma, H3K27M- mutant Effectively Treated with Bevacizumab: A Report of Two Cases

Author

YABUNO, Satoru, primary, KAWAUCHI, Satoshi, additional, UMAKOSHI, Michiari, additional, UNEDA, Atsuhito, additional, FUJII, Kentaro, additional, ISHIDA, Joji, additional, OTANI, Yoshihiro, additional, HATTORI, Yasuhiko, additional, TSUBOI, Nobushige, additional, KOHNO, Shohei, additional, NOUJIMA, Mai, additional, TOJI, Tomohiro, additional, YANAI, Hiroyuki, additional, YASUHARA, Takao, additional, and DATE, Isao, additional

Published
2021
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37. Correction to: PD-L1 expression in tongue squamous cell carcinoma

Author

Akisada, Naoki, primary, Nishimoto, Kohei, additional, Takao, Soshi, additional, Gion, Yuka, additional, Marunaka, Hidenori, additional, Tachibana, Tomoyasu, additional, Makino, Takuma, additional, Miki, Kentaro, additional, Akagi, Yusuke, additional, Tsumura, Munechika, additional, Toji, Tomohiro, additional, Yoshino, Tadashi, additional, Nishizaki, Kazunori, additional, Orita, Yorihisa, additional, and Sato, Yasuharu, additional

Published
2020
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38. Accuracy of Endoscopic Transpapillary Gallbladder Drainage with Liquid-Based Cytology for Gallbladder Disease.

Author

Kawahara, Soichiro, Tomoda, Takeshi, Kato, Hironari, Ueki, Toru, Akimoto, Yutaka, Harada, Ryo, Toji, Tomohiro, and Okada, Hiroyuki

Subjects
GALLBLADDER cancer, GALLBLADDER, CYTOLOGY, OBSTRUCTIVE jaundice, BILE ducts, ENDOSCOPIC ultrasonography, CHOLANGIOGRAPHY, CONSERVATIVE treatment
Abstract

Introduction: Gallbladder carcinoma is often difficult to distinguish from benign gallbladder diseases. While the diagnostic accuracy of endoscopic transpapillary gallbladder drainage (ETGD) has been reported, these results were obtained retrospectively. This prospective study aimed to evaluate the cytological diagnostic accuracy of ETGD in patients with gallbladder disease. Methods: This single-arm prospective clinical trial included a total of 35 patients scheduled to undergo ETGD between March 2017 and September 2019. A 5F pigtail nasobiliary drainage tube was inserted into the gallbladder, and bile was collected over 5 times; if ETGD failed, a drainage tube was placed into the bile duct. The endpoints were, first, the cytological diagnostic accuracy of ETGD and, second, technical success rates and adverse events. Results: Of the 35 patients, 19 were finally diagnosed with gallbladder cancer. The success rate of ETGD tube insertion was 85.7%, and the morphological pattern of the cystic duct with the angle down and located on the right side had a significantly lower success rate for ETGD than that of other cystic duct patterns (odds ratio, 13.5; 95% confidence interval, 1.7–143.7; p = 0.02). Cytological samples were collected 5 times on median. The sensitivity, specificity, and accuracy in all patients were 78.9%, 100%, and 88.6%, respectively, while those in 30 patients with successful ETGD were 87.5%, 100%, and 93.3%, respectively. Adverse events occurred in 3 patients: mild pancreatitis in 1 patient and obstructive jaundice in 2 patients; all complications were resolved with conservative therapy. Discussion/Conclusions: Cytology using an ETGD tube is useful in differentiating benign and malignant gallbladder diseases (Clinical Trial Registry No. UMIN000026929). [ABSTRACT FROM AUTHOR]

Published
2022
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41. The neutrophil-to-lymphocyte ratio as a novel independent prognostic factor for multiple metastatic lung tumors from various sarcomas

Author

Yamamoto, Hiromasa, primary, Namba, Kei, additional, Yamamoto, Haruchika, additional, Toji, Tomohiro, additional, Soh, Junichi, additional, Shien, Kazuhiko, additional, Suzawa, Ken, additional, Kurosaki, Takeshi, additional, Otani, Shinji, additional, Okazaki, Mikio, additional, Sugimoto, Seiichiro, additional, Yamane, Masaomi, additional, Takahashi, Katsuhito, additional, Kunisada, Toshiyuki, additional, Oto, Takahiro, additional, and Toyooka, Shinichi, additional

Published
2020
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42. PD-L1 expression in tongue squamous cell carcinoma

Author

Akisada, Naoki, primary, Nishimoto, Kohei, additional, Takao, Soshi, additional, Gion, Yuka, additional, Marunaka, Hidenori, additional, Tachibana, Tomoyasu, additional, Makino, Takuma, additional, Miki, Kentaro, additional, Akagi, Yusuke, additional, Tsumura, Munechika, additional, Toji, Tomohiro, additional, Yoshino, Tadashi, additional, Nishizaki, Kazunori, additional, Orita, Yorihisa, additional, and Sato, Yasuharu, additional

Published
2020
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43. A case of triple seronegative myasthenia gravis with Graves' disease ameliorated after the removal of enlarged thymus with elevated uptake in fluorine‐18 fluorodeoxyglucose positron emission tomography

Author

Matsumoto, Namiko, primary, Omote, Yoshio, additional, Nakano, Yumiko, additional, Takemoto, Mami, additional, Hishikawa, Nozomi, additional, Sato, Kota, additional, Ohta, Yasuyuki, additional, Yamashita, Toru, additional, Toji, Tomohiro, additional, and Abe, Koji, additional

Published
2020
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44. The clinicopathological features of submucosal invasive non-ampullary duodenal carcinoma

Author

Matsueda, Katsunori, primary, Kanzaki, Hiromitsu, additional, Takenaka, Ryuta, additional, Nakagawa, Masahiro, additional, Matsueda, Kazuhiro, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, Toji, Tomohiro, additional, Tanaka, Takehiro, additional, Yagi, Takahito, additional, Fujiwara, Toshiyoshi, additional, and Okada, Hiroyuki, additional

Published
2020
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45. What Are the Results of Resection of Localized Dedifferentiated Liposarcomas in the Extremities?

Author

Eiji Nakata, Toshiyuki Kunisada, Joe Hasei, Ryuichi Nakahara, Hiroyuki Yanai, Tomohiro Toji, Hirofumi Inoue, Toshifumi Ozaki, Nakata, Eiji, Kunisada, Toshiyuki, Hasei, Joe, Nakahara, Ryuichi, Yanai, Hiroyuki, Toji, Tomohiro, Inoue Ct, Hirofumi, and Ozaki, Toshifumi

Subjects
EXTREMITIES (Anatomy) -- Surgery, EXTREMITIES (Anatomy), RETROSPECTIVE studies, KAPLAN-Meier estimator, LIPOSARCOMA
Abstract

Background: Dedifferentiated liposarcoma (DDLPS) is a rare malignancy that transitions from an atypical lipomatous tumor to a sarcoma with a variable morphologic appearance. The behavior of this tumor in the retroperitoneum is aggressive, but the behavior of DDLPS in the extremities is less well-defined because it is rare. Few reports have assessed the imaging features and clinical outcomes of primary DDLPS in the extremities.Questions/purposes: In patients with primary DDLPS of the extremity, we asked the following questions: (1) How frequently do additional primary malignancies occur in patients with DDLPS? (2) What is the rate of overall survival, metastases, and local recurrence in DDLPS? (3) What factors are associated with metastasis-free survival and local recurrence in DDLPS?Methods: We defined DDLPS as a biphasic neoplasm that transitions from an atypical lipomatous tumor (ALT) to a sarcoma of variable morphologic appearance and histologic grades. We retrospectively evaluated the medical records of patients with DDLPS of the extremities who underwent surgery in our institution between 2003 and 2017. During that time, 16 patients were treated for this diagnosis; one was excluded from this study because the patient did not have an MRI, leaving 15 patients (nine men, six women; their median [range] age was 67 years [42 to 87]) for evaluation. All had a minimum of 2 years follow-up (median [range] 54 months [25 to 136]); 14 of 15 have been seen in the last 5 years (one patient, who was doing well at the time, was lost after 9 years of follow-up). In 11 patients, MRI demonstrated two components: an ALT component with high intensity on both T1-weighed and T2-weighted sequences and a dedifferentiated component low-to-intermediate intensity on T1-weighed and heterogeneous hyperintensity on T2-weighted sequence. Nine patients were evaluated using 2-deoxy-2-18F-fluoro-D-glucose positron emission tomography (FDG-PET) combined with CT (PET/CT). PET/CT showed a biphasic pattern with a close relationship to MRI findings. The dedifferentiated component presented with high FDG uptake (median [range] maximum standardized uptake value 5.1 [1.9 to 22.6]), while the atypical lipomatous tumor component showed almost no FDG uptake. In all patients, immunohistochemical studies of p16 and cyclin-dependent kinase-4 (CDK4) were investigated. Positive staining for both p16 and CDK4 were seen in 13 of 15 patients.We retrospectively evaluated the electronic medical records of all patients in our institution for the presence of additional primary malignancies, local recurrence-free survival, metastasis-free survival, and overall survival. The survival rate was estimated using the Kaplan-Meier method. The Wilcoxon exact test was used to determine the prognostic importance of the following survival variables: age, sex, maximum tumor size, radiotherapy, and surgical margin.Results: Seven additional primary malignancies developed in five of 15 patients (two lung cancers, two sarcomas, one renal cell cancer, one uterine cancer, and one non-Hodgkin lymphoma). The 3- and 5-year metastasis-free survival rates were 86% (95% CI 0.67 to 1.00) and 75% (95% CI 0.49 to 1.00), respectively. With the numbers available, we found no factors associated with metastasis-free survival. The 3- and 5-year overall survival rates were 100% (95% CI 1.00 to 1.00) and 88% (95% CI 0.65 to 1.00), respectively. Three of 15 patients had local recurrence. The 3- and 5-year local recurrence-free survival rates were 86% (95% CI 0.67 to 1.00) and 75% (95% CI 0.49 to 1.00), respectively. Large (> 15 cm) tumors were more likely to have a local recurrence (p = 0.04).Conclusions: In this small series, we found that the extremities are a favorable site for DDLPS compared with the retroperitoneum, although we did not directly compare the two sites. This rare tumor has a relatively high likelihood of being associated with other malignancies. We believe patients should be assessed and monitored carefully for this possibility. In the future, larger studies are needed to better define predictors of local recurrence, although the tumor's size may be associated with a greater propensity for local recurrence.Level Of Evidence: Level II, prognostic study. [ABSTRACT FROM AUTHOR]

Published
2020
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