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In this study, we aimed to evaluate the effect of infertility duration and dominant follicle size measured on the day of human chorionic gonadotropin (HCG) administration on pregnancy rates in infertile women undergoing ovulation induction (OI) with gonadotropin (GND). A total of 352 patients aged 20 to 41 years who were diagnosed with unexplained infertility or polycystic ovary syndrome (PCOS) were included in this study. Patients with a history of multifollicular development or follicle stimulating hormone (FSH) value more than 12 IU/ml were excluded from the study. The demographic and clinical features of the patients were obtained from the patients' files and hospital automation system and recorded for each woman. The demographic and clinical features of the patients were recorded. Patients were divided into two groups as live birth (group 1, n = 47) and non-live birth groups (group 2, n = 305). There were no statistically significant differences in regard to age, infertility type, follicle stimulating hormone (FSH) level, oestradiol (E2) level, antral follicle count (AFC), cycle characteristics, GND type, number of follicles, E2 level and endometrial thickness on HCG day, total GND dose, dominant follicle size (p > 0.05). Infertility duration in group 1 was 3.5 ± 2.1; in group 2, 4.7 ± 3.9 years. This difference was statistically significant (p =.014). According to this study, live birth rates after GND + IUIs(intrauterine insemination) were significantly affected by the duration of infertility. But the dominant follicle size and endometrial thickness measured on HCG day in GND and IUI cycles did not have a significant effect on pregnancy rates. What is already known on the subject? It is thought that the timing of the ovarian triggering is vital for the success of intrauterine insemmination (IUI) treatment. What do the results of this study add? According to our results live birth rates after GND + IUIs were significantly affected by the duration of infertility. What are the implications of these findings for clinical practice and/or further research? It is determined that the duration of infertility is significant and patients should be encouraged to the treatment as soon as possible. [ABSTRACT FROM AUTHOR]

Hydatidiform mole (HM) is a gestational trophoblastic disease. Potential risk factors are advanced maternal age, reproductive factors, oral contraceptive use, history of gestational trophoblastic disease, oxidative stress, and other environmental factors. Serum amyloid A (SAA) protein has an important role in acute phase response but is also associated with pathologic fibril formation in chronic inflammation. The aim of the current study is to determine the relationship between maternal SAA levels in patients with both complete hydatidiform mole (CHM) and partial hydatidiform mole (PHM), and to examine its potential role in the disease in pathogenesis. Fifty healthy pregnant women in the first trimester of pregnancy with completely normal pregnancy follow-up, and 50 patients who were diagnosed with HM, who were also in the first trimester of pregnancy included in the study. There was no difference between patients and the control group according to body mass index (BMI), gravidity, parity, number of living children, number of miscarriages, level of blood TSH, and hemoglobin level between the two groups. SAA levels in patients with HM were significantly higher than those in healthy controls. This may be an important underexplored pathway mediating the relationship between oxidative stress and abnormal placental proliferation. [ABSTRACT FROM AUTHOR]

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We sought to investigate the value of progranulin (PGRN) in predicting the response of the ovary to controlled ovarian hyperstimulation (COH) during in vitro fertilisation (IVF) cycles. Eighty eight women were recruited to one of three groups: poor-responders (group I), hyper-responders (group II), and normo-responders (group III). Data recorded for each woman included demographics, cycle characteristics, laboratory biomarkers, and IVF outcomes. Baseline PGRN levels were measured in venous sera. The distribution of the patients among the groups was as follows: 26 patients comprised group I, 35 patients group II, and 27 patients group III. The groups were matched in terms of body mass index. The overall clinical pregnancy rate was 38.6%. There was no significant difference between the groups in pregnancy rates. A PGRN level less than or equal to 3.2 ng/mL was associated with poor ovarian response independent of ovarian reserve markers. It is concluded that PGRN and other ovarian reserve markers are unable to predict pregnancy. However, poor ovarian response to COH could be predicted from basal serum PGRN concentration. [ABSTRACT FROM AUTHOR]