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178 results on '"Tokunaga, Masayoshi"'

14. Morphological and biochemical evidence of muscle hyperplasia following weight-lifting exercise in rats

Author

Tamaki, Tetsuro, Akatsuka, Akira, Tokunaga, Masayoshi, Ishige, Kazuto, Uchiyama, Shuichi, and Shiraishi, Takemasa

Subjects
Hyperplasia -- Measurement, Weight lifting (Sports) -- Physiological aspects, Muscles -- Research, Biological sciences
Abstract

Research shows that rat muscle exhibits acute muscle hyperplasia directly after strenuous weight-lifting activity. Amino acid uptake and myosin synthesis was measured using radioactively-labelled [3H]thymidine and [14C]leucine to assess evidence of hyperplasia. Increases in both activities were observed throughout the 14-day experiment. Cell proliferation assessments were taken using immunohistochemical labelling with 5-bromo-2'-deoxyuridine.

Published
1997

21. Salivary gland tumors among atomic bomb survivors, 1950-1987

Author

Saku, Takashi, Hayashi, Yuzo, Takahara, Osamu, Matsuura, Hiroo, Tokunaga, Masayoshi, Tokuoka, Shoji, Soda, Midori, Mabuchi, Kiyohiko, and Land, Charles E.

Subjects
Atomic bomb victims -- Health aspects, Mouth tumors -- Demographic aspects, Health
Published
1997

23. Epstein-Barr virus and gastric remnant cancer

Author

Yamamoto, Noriko, Tokunaga, Masayoshi, Uemura, Yoshiko, Tanaka, Sadao, Shirahama, Hiroshi, Nakamura, Takao, Land, Charles E., and Sato, Eiichi

Subjects
Stomach cancer -- Causes of, Epstein-Barr virus diseases -- Complications, Health
Abstract

Background. Carcinoma arising in the gastric remnant many years after partial gastrectomy for benign disease, referred to as gastric remnant cancer (GRC) is well known, and many causal explanations have been proposed. Elsewhere, Epstein-Barr virus (EBV) involvement has been demonstrated in a small but significant fraction of gastric cancers, and evidence has been presented suggesting that, in positive cases, EBV may have played a causal role. The present report is concerned with EBV involvement in GRC in particular. Methods. Paraffin sections from 48 cases of GRC were studied by EBER-1 in situ hybridization. Results. Thirteen cases (27.1%) showed uniform hybridized signals restricted to the carcinoma cells in contrast to no hybridization in the normal mucosa, intestinal metaplasia, or hyperplastic epithelium. The prevalence of EBV involvement in GRC was significantly higher (P < 0.0001) than in gastric carcinomas from 1825 nonremnant cases; the difference remained highly significant even when the comparison was restricted to nonremnant cancers arising in the cardia and middle stomach. for which EBV-positive rates were highest. Conclusion. The EBV may play an important role in the carcinogenesis of GRC. Cancer 1994; 74:805-9. Key words: Epstein-Barr virus, gastric cancer, gastric remnant cancer, EBER-1 in situ hybridization.

Published
1994

24. Proliferative and nonproliferative breast disease in atomic bomb survivors: results of a histopathologic review of autopsy breast tissue

Author

Tokunaga, Masayoshi, Land, Charles E., Aoki, Yoichiro, Yamamoto, Tsutomu, Asano, Masahide, Sato, Eiichi, Tokuoka, Shoji, Sakamoto, Goi, and Page, David L.

Subjects
Breast diseases -- Development and progression, Breast cancer -- Risk factors, Tumors, Radiation-induced -- Physiological aspects, Atomic bomb victims -- Health aspects, Health
Abstract

Background. The risk of female breast cancer in association with radiation dose is well established, on the basis of follow-up studies of the atomic bomb survivors and other exposed populations. This association is especially strong for women exposed before 20 years of age and appears to be much weaker among women exposed after 40 years of age. Methods. Breast tissue samples from 88 high-dose and 225 low-dose autopsy cases from the Radiation Effects Research Foundation Life Span Study sample were examined in detail to determine whether nonproliferative and proliferative breast lesions are associated with radiation dose. Results. Prevalence of proliferative disease in general and atypical hyperplasia in particular were positively associated with radiation dose. The associations were strongest for subjects who were between 40 and 49 years of age at the time of the bombing. Conclusions. It is hypothesized that the strongest association in women 40 to 49 years of age may be related to the age dependence of radiation-induced breast cancer, in that potential cancers induced in this age group by radiation exposure may receive too little hormonal promotion to progress to frank cancers.

Published
1993

31. A Family Predisposition to Adult T-Cell Leukemia

Author

Nomura, Kouichiro, primary, Utsunomiya, Atae, additional, Furushou, Hironori, additional, Tara, Mitsutoshi, additional, Hazeki, Masashi, additional, Tokunaga, Masayoshi, additional, Uozumi, Kimiharu, additional, Hanada, Shuichi, additional, Yashiki, Shinji, additional, Tajima, Kazuo, additional, and Sonoda, Shunro, additional

Published
2006
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35. Epstein‐Barr virus involvement is mainly restricted to lymphoepithelial type of gastric carcinoma among various epithelial neoplasms

Author

Kijima, Yuko, primary, Hokita, Shuichi, additional, Takao, Sonshin, additional, Baba, Masamichi, additional, Natsugoe, Shoji, additional, Yoshinaka, Heiji, additional, Aridome, Kuniaki, additional, Otsuji, Tatsuto, additional, Itoh, Tetsuhiko, additional, Tokunaga, Masayoshi, additional, Eizuru, Yoshito, additional, and Aikou, Takashi, additional

Published
2001
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36. Liver Cancer in Atomic-bomb Survivors: Histological Characteristics and Relationships to Radiation and Hepatitis B and C Viruses

Author

FUKUHARA, TOSHIYUKI, primary, SHARP, GERALD B., additional, MIZUNO, TERUMI, additional, ITAKURA, HIDEYO, additional, YAMAMOTO, MASAMI, additional, TOKUNAGA, MASAYOSHI, additional, TOKUOKA, SHOJI, additional, COLOGNE, JOHN B., additional, FUJITA, YASUYUKI, additional, SODA, MIDORI, additional, and MABUCHI, KIYOHIKO, additional

Published
2001
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46. Effects of Enalapril in children with IgA Nephropathy.

Author

Ninomiya, Makoto, primary, Ohkawa, Toshiya, additional, Kiyoshi, Yasuhiro, additional, Nakashima, Ryuji, additional, Nakamura, Shigeyuki, additional, Kuwahata, Masato, additional, Nagamatsu, Shozo, additional, Miyata, Koichiro, additional, Tokunaga, Masayoshi, additional, and Take, Hiromichi, additional

Published
1995
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49. Epstein‐Barr virus related gastric cancer in Japan: A molecular patho‐epidemiological study

Author

Tokunaga, Masayoshi, primary, Uemura, Yoshiko, additional, Tokudome, Takahiro, additional, Ishidate, Takuzo, additional, Masuda, Hirotake, additional, Okazaki, Etsuo, additional, Kaneko, Kou, additional, Naoe, Shiro, additional, Ito, Masafumi, additional, Okamura, Akiharu, additional, Shimada, Atsuko, additional, Sato, Eiichi, additional, and Land, Charles E., additional

Published
1993
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50. EBER-1 expression in thymic carcinoma

Author

Fujii, Takeshi, primary, Kawal, Toshiro, additional, Saito, Ken, additional, Fukushima, Kanae, additional, Hasegawa, Tsuguo, additional, Tokunaga, Masayoshi, additional, and Yokoyama, Takeshi, additional

Published
1993
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