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1. Docking-Based Virtual Screening Enables Prioritizing Protein Kinase Inhibitors With In Vitro Phenotypic Activity Against Schistosoma mansoni

Author

Bernardo Pereira Moreira, Izabella Cristina Andrade Batista, Naiara Clemente Tavares, Tom Armstrong, Sandra Grossi Gava, Gabriella Parreiras Torres, Marina Moraes Mourão, and Franco H. Falcone

Subjects
Schistosoma mansoni (S. mansoni), protein kinases, kinase inhibitor, in silico drug screening, in vitro phenotypic screening, ATP pocket, Microbiology, QR1-502
Abstract

Schistosomiasis is a parasitic neglected disease with praziquantel (PZQ) utilized as the main drug for treatment, despite its low effectiveness against early stages of the worm. To aid in the search for new drugs to tackle schistosomiasis, computer-aided drug design has been proved a helpful tool to enhance the search and initial identification of schistosomicidal compounds, allowing fast and cost-efficient progress in drug discovery. The combination of high-throughput in silico data followed by in vitro phenotypic screening assays allows the assessment of a vast library of compounds with the potential to inhibit a single or even several biological targets in a more time- and cost-saving manner. Here, we describe the molecular docking for in silico screening of predicted homology models of five protein kinases (JNK, p38, ERK1, ERK2, and FES) of Schistosoma mansoni against approximately 85,000 molecules from the Managed Chemical Compounds Collection (MCCC) of the University of Nottingham (UK). We selected 169 molecules predicted to bind to SmERK1, SmERK2, SmFES, SmJNK, and/or Smp38 for in vitro screening assays using schistosomula and adult worms. In total, 89 (52.6%) molecules were considered active in at least one of the assays. This approach shows a much higher efficiency when compared to using only traditional high-throughput in vitro screening assays, where initial positive hits are retrieved from testing thousands of molecules. Additionally, when we focused on compound promiscuity over selectivity, we were able to efficiently detect active compounds that are predicted to target all kinases at the same time. This approach reinforces the concept of polypharmacology aiming for “one drug-multiple targets”. Moreover, at least 17 active compounds presented satisfactory drug-like properties score when compared to PZQ, which allows for optimization before further in vivo screening assays. In conclusion, our data support the use of computer-aided drug design methodologies in conjunction with high-throughput screening approach.

Published
2022
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3. New InhA Inhibitors Based on Expanded Triclosan and Di-Triclosan Analogues to Develop a New Treatment for Tuberculosis

Author

Sarentha Chetty, Tom Armstrong, Shalu Sharma Kharkwal, William C. Drewe, Cristina I. De Matteis, Dimitrios Evangelopoulos, Sanjib Bhakta, and Neil R. Thomas

Subjects
tuberculosis, structure-based drug-design, molecular modelling, InhA, triazole, triclosan, Medicine, Pharmacy and materia medica, RS1-441
Abstract

The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has reinforced the need for the development of new anti-TB drugs. The first line drug isoniazid inhibits InhA. This is a prodrug requiring activation by the enzyme KatG. Mutations in KatG have largely contributed to clinical isoniazid resistance. We aimed to design new ‘direct’ InhA inhibitors that obviate the need for activation by KatG, circumventing pre-existing resistance. In silico molecular modelling was used as part of a rational structure-based drug-design approach involving inspection of protein crystal structures of InhA:inhibitor complexes, including the broad spectrum antibiotic triclosan (TCS). One crystal structure exhibited the unusual presence of two triclosan molecules within the Mycobacterium tuberculosis InhA binding site. This became the basis of a strategy for the synthesis of novel inhibitors. A series of new, flexible ligands were designed and synthesised, expanding on the triclosan structure. Low Minimum Inhibitory Concentrations (MICs) were obtained for benzylphenyl compounds (12, 43 and 44) and di-triclosan derivative (39), against Mycobacterium bovis BCG although these may also be inhibiting other enzymes. The ether linked di-triclosan derivative (38) displayed excellent in vitro isolated enzyme inhibition results comparable with triclosan, but at a higher MIC (125 µg mL−1). These compounds offer good opportunities as leads for further optimisation.

Published
2021
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4. PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer

Author

Paula Ghaneh, Robert Hanson, Andrew Titman, Gill Lancaster, Catrin Plumpton, Huw Lloyd-Williams, Seow Tien Yeo, Rhiannon Tudor Edwards, Colin Johnson, Mohammed Abu Hilal, Antony P Higginson, Tom Armstrong, Andrew Smith, Andrew Scarsbrook, Colin McKay, Ross Carter, Robert P Sutcliffe, Simon Bramhall, Hemant M Kocher, David Cunningham, Stephen P Pereira, Brian Davidson, David Chang, Saboor Khan, Ian Zealley, Debashis Sarker, Bilal Al Sarireh, Richard Charnley, Dileep Lobo, Marianne Nicolson, Christopher Halloran, Michael Raraty, Robert Sutton, Sobhan Vinjamuri, Jonathan Evans, Fiona Campbell, Jon Deeks, Bal Sanghera, Wai-Lup Wong, and John P Neoptolemos

Subjects
pancreatic cancer, positron emission tomography/computed tomography, diagnosis, accuracy, Medical technology, R855-855.5
Abstract

Background: Pancreatic cancer diagnosis and staging can be difficult in 10–20% of patients. Positron emission tomography (PET)/computed tomography (CT) adds precise anatomical localisation to functional data. The use of PET/CT may add further value to the diagnosis and staging of pancreatic cancer. Objective: To determine the incremental diagnostic accuracy and impact of PET/CT in addition to standard diagnostic work-up in patients with suspected pancreatic cancer. Design: A multicentre prospective diagnostic accuracy and clinical value study of PET/CT in suspected pancreatic malignancy. Participants: Patients with suspected pancreatic malignancy. Interventions: All patients to undergo PET/CT following standard diagnostic work-up. Main outcome measures: The primary outcome was the incremental diagnostic value of PET/CT in addition to standard diagnostic work-up with multidetector computed tomography (MDCT). Secondary outcomes were (1) changes in patients’ diagnosis, staging and management as a result of PET/CT; (2) changes in the costs and effectiveness of patient management as a result of PET/CT; (3) the incremental diagnostic value of PET/CT in chronic pancreatitis; (4) the identification of groups of patients who would benefit most from PET/CT; and (5) the incremental diagnostic value of PET/CT in other pancreatic tumours. Results: Between 2011 and 2013, 589 patients with suspected pancreatic cancer underwent MDCT and PET/CT, with 550 patients having complete data and in-range PET/CT. Sensitivity and specificity for the diagnosis of pancreatic cancer were 88.5% and 70.6%, respectively, for MDCT and 92.7% and 75.8%, respectively, for PET/CT. The maximum standardised uptake value (SUVmax.) for a pancreatic cancer diagnosis was 7.5. PET/CT demonstrated a significant improvement in relative sensitivity (p = 0.01) and specificity (p = 0.023) compared with MDCT. Incremental likelihood ratios demonstrated that PET/CT significantly improved diagnostic accuracy in all scenarios (p

Published
2018
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20. Detection of extended TeV emission around the Geminga pulsar with H.E.S.S

Author

Michael Punch, Christo Venter, Christian Stegmann, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, M. Hörbe, L. Mohrmann, Hassan Abdalla, Albert Seyffert, Michael Backes, Laenita Lorraine Oberholzer, Dieter Horns, K. Nakashima, Tim Holch, K. Bernloehr, Naomi Tsuji, Heinrich J. Völk, Regis Terrier, Carlo Romoli, Gerard Fontaine, Tadayuki Takahashi, M. Fuessling, Hester Schutte, S. Steinmassl, Samuel Timothy Spencer, Sami Caroff, Victor Doroshenko, Frank M. Rieger, Clemens Hoischen, A. A. Zdziarski, P. T. O'Brien, Markus Holler, Q. Remy, Felix Jankowsky, Hannah Dalgleish, German Hermann, Paul Morris, Anne Lemiere, E. Kasai, Louis Du Plessis, Johann van der Walt, Martin Tluczykont, Dan Parsons, Anna Barnacka, D. Malyshev, Nukri Komin, Tom Armstrong, Felix Aharonian, Gilles Maurin, J. F. Glicenstein, David Sanchez, Krzysztof Katarzynski, Victor Barbosa Martins, Ira Jung, C. Arcaro, Sebastian Panny, Gianluca Giavitto, Angel Noel, Bruno Khelifi, Alison Mitchell, Santiago Pita, Werner Hofmann, Gašper Kukec Mezek, Atreyee Sinha, Emma Ona-Wilhelmi, Jonathan Mackey, Carlo van Rensburg, Gerd Puehlhofer, Lei Sun, Laura Olivera-Nieto, Hambeleleni Ndiyavala, Floriane Cangemi, A. Yusafzai, C. Levy, Alexandre Marcowith, Felix Werner, Thomas Lohse, Hend Yassin, Anton Dmytriiev, Manuel Meyer, Arnaud Mares, Manami Sasaki, Mathieu Naurois, Catherine Boisson, Jhilik Majumdar, N. Zywucka, Sumari Hattingh, Takaaki Tanaka, Gavin Rowell, Hector Rueda Ricarte, Mathieu Bony, Oguzhan Anguener, C. Moore, Riaan Steenkamp, Richard White, Kirsty Feijen, Heike Prokoph, Thomas Bylund, Rowan Batzofin, Andreas Zmija, Dorit Glawion, Samuel Zouari, Tomasz Bulik, Robert Brose, Andrea Santangelo, Jacco Vink, Michal Ostrowski, Anna Luashvili, Jacques Muller, Malgorzata Curlo, Marion Spir-Jacob, M. Lemoine-Goumard, Lente Dreyer, David Huber, J.-P. Lenain, Matthieu Renaud, Amid Nayerhoda, Hugh Spackman, Michael Kreter, Justine Devin, Sabrina Casanova, Anu Kundu, Stefan Klepser, V. Sahakian, G. Peron, Alessandro Montanari, Garret Cotter, Vikas Joshi, Zhiqiu Huang, T. Chand, Lott Frans, D. A. Prokhorov, K. Kosack, Sylvia Zhu, P. J. Meintjes, David Berge, Yves Gallant, Lukasz Stawarz, Stefan Ohm, Halim Ashkar, Fabian Leuschner, Jason John Watson, Davit Zargaryan, Arache Djannati-Ataï, Johannes Schaefer, S. J. Fegan, Andreas Quirrenbach, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Stefan Funk, Alicja Wierzcholska, Guillem Marti'i-Devesa, P. Reichherzer, V. Poireau, Jimmy N.S. Shapopi, Jaqueline Catalano, Stefano Gabici, Ramin Marx, M. Panter, Michael Zacharias, Jim Hinton, Jean-Pierre Ernenwein, U. Katz, G. Lamanna, R. Konno, Isak Delberth Davids, Fabian Schüssler, A. Fiasson, Sabrina Einecke, Iryna Lypova, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Roberta Zanin, Emmanuel Moulin, Andrew Taylor, B. Rudak, Kathrin Egberts, Johannes Veh, J. Bolmont, Faical Ait-Benkhali, Kleopas Shiningayamwe, Jacek Niemiec, G. Vasileiadis, Monica Barnard, Yvonne Becherini, Denys Malyshev, Maria Haupt, Olaf Reimer, Edna Ruiz Velasco, Lenka Tomankova, Sébastien Le Stum, Thomas Murach, Christopher van Eldik, Rafal Moderski, Mohanraj Senniappan, Francois Brun, P. Vincent, Heiko Salzmann, Andreas Specovius, Yu Wun Wong, Vincent Marandon, Hannes Thiersen, Vardan Baghmanyan, Celine Armand, Dmitriy Kostunin, L. Giunti, Brian van Soelen, Thomas Tavernier, Markus Boettcher, Michelle Tsirou, M.-H. Grondin, Rachel Simoni, Anita Reimer, Constantin Steppa, Ullrich Schwanke, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Brian Reville, Connor Duffy, James Davies, R. J. Tuffs, B. Bi, Mischa Breuhaus, Pauline Chambery, Marek Jamrozy, Helene Sol, Paolo Marchegiani, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), and H.E.S.S.

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Astrophysics::High Energy Astrophysical Phenomena, Gamma rays, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, imaging, Astronomy, IACT, Cosmology, Tellurium compounds, Cherenkov counter, gamma ray: emission, Pulsar, HESS, Milagro, TeV, HESS - Abteilung Hinton, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - High Energy Astrophysical Phenomena, HAWC, Cosmic rays, Cherenkov radiation, pulsar
Abstract

Highly extended gamma-ray emission around the Geminga pulsar was discovered by Milagro and verified by HAWC. Despite many observations with Imaging Atmospheric Cherenkov Telescopes (IACTs), detection of gamma-ray emission on angular scales exceeding the IACT field-of-view has proven challenging. Recent developments in analysis techniques have enabled the detection of significant emission around Geminga in archival data with H.E.S.S.. In 2019, further data on the Geminga region were obtained with an adapted observation strategy. Following the announcement of the detection of significant TeV emission around Geminga in archival data, in this contribution we present the detection in an independent dataset. New analysis results will be presented, and emphasis given to the technical challenges involved in observations of highly extended gamma-ray emission with IACTs., PoS: Proceedings of Science, 395, ISSN:1824-8039, Proceedings of 37th International Cosmic Ray Conference

Published
2022

21. Searching for VHE gamma-ray emission associated with IceCube neutrino alerts using FACT, H.E.S.S., MAGIC, and VERITAS

Author

Konstancja, Satalecka, Acciari, Victor A., Stefano, Ansoldi, Lucio Angelo Antonelli, Axel Arbet Engels, Manuel, Artero, Katsuaki, Asano, Dominik, Baack, Ana, Babic, Andr('(e))s, Baquero, Ulisses Barres de Almeida, Juan Abel Barrio, Ivana, Batkovi('(c)), Josefa Becerra Gonzalez, Wlodek, Bednarek, Lorenzo, Bellizzi, Elisa, Bernardini, Maria-Isabel, Bernardos, Alessio, Berti, Jürgen, Besenrieder, Wrijupan, Bhattacharyya, Ciro, Bigongiari, Adrian, Biland, Oscar, Blanch, Hendrik, Bökenkamp, Giacomo, Bonnoli, Zeljka, Bosnjak, Giovanni, Busetto, Roberto, Carosi, Giovanni, Ceribella, Matteo, Cerruti, Yating, Chai, Ashot, Chilingarian, Stefan, Cikota, Sidika Merve Colak, Eduardo, Colombo, Jose Luis Contreras, Juan, Cortina, Stefano, Covino, Giacomo D( extquotesingle)Amico, Valerio D( extquotesingle)Elia, Paolo Da Vela, Francesco, Dazzi, Alessandro De Angelis, Barbara De Lotto, Manuel, Delfino, Jordi, Delgado, Carlos Delgado Mendez, Davide, Depaoli, Federico Di Pierro, Leonardo Di Venere, Elia Do Souto Espi(~(n))eira, Dijana Dominis Prester, Alice, Donini, Daniela, Dorner, Michele, Doro, Dominik, Elsaesser, Vandad Fallah Ramazani, Alicia, Fattorini, Maria Victoria Fonseca, Lluis, Font, Christian, Fruck, Satoshi, Fukami, Yasushi, Fukazawa, Garc('(i))a L('(o))pez, Ramon J., Markus, Garczarczyk, Sargis, Gasparyan, Markus, Gaug, Giglietto, Nicola, Francesco, Giordano, Pawel, Gliwny, Nikola, Godinovic, David, Green, Jarred Gershon Green, Daniela, Hadasch, Alexander, Hahn, Lea, Heckmann, Javier, Herrera, John, Hoang, Dario, Hrupec, Moritz, Hütten, Tomohiro, Inada, Kazuma, Ishio, Yuki, Iwamura, Irene Jim('(e))nez Mart('(i))nez, Jenni, Jormanainen, L('(e))a, Jouvin, Marie, Karjalainen, Daniel, Kerszberg, Yukiho, Kobayashi, Hidetoshi, Kubo, Junko, Kushida, Alessandra, Lamastra, Damir, Lelas, Francesco, Leone, Elina, Lindfors, Lena, Linhoff, Saverio, Lombardi, Francesco, Longo, Ruben, Lopez-Coto, Marcos, L('(o))pez-Moya, Alicia, L('(o))pez-Oramas, Loporchio, Serena, Bernardo Machado de Oliveira Fraga, Camilla, Maggio, Pratik, Majumdar, Martin, Makariev, Manuela, Mallamaci, Galina, Maneva, Marina, Manganaro, Karl, Mannheim, Laura, Maraschi, Mos(`(e)), Mariotti, Manel, Martinez, Daniel, Mazin, Stefano, Menchiari, Simone, Mender, Sa( (s))a Mi('(c))anovi('(c)), Davide, Miceli, Tjark, Miener, Jose Miguel Miranda, Razmik, Mirzoyan, Edgar, Molina, Abelardo, Moralejo, Daniel, Morcuende, Victoria, Moreno, Elena, Moretti, Takeshi, Nakamori, Lara, Nava, Vitaly, Neustroev, Cosimo, Nigro, Kari, Nilsson, Kyoshi, Nishijima, Koji, Noda, Seiya, Nozaki, Yoshiki, Ohtani, Tomohiko, Oka, Jorge, Otero-Santos, Simona, Paiano, Michele, Palatiello, David, Paneque, Riccardo, Paoletti, Paredes, Josep M., Lovro, Pavleti('(c)), Pablo, Pe(~(n))il, Massimo, Persic, Marine, Pihet, Pier Giorgio Prada Moroni, Elisa, Prandini, Chaitanya, Priyadarshi, Ivica, Puljak, Wolfgang, Rhode, Marc, Rib('(o)), Javier, Rico, Chiara, Righi, Andrea, Rugliancich, Narek, Sahakyan, Takayuki, Saito, Shunsuke, Sakurai, Francesco Gabriele Saturni, Bernd, Schleicher, Kevin, Schmidt, Thomas, Schweizer, Julian, Sitarek, Iva, ( (S))nidari('(c)), Dorota, Sobczy('(n))ska, Alessia, Spolon, Antonio, Stamerra, Jelena Stri( (s))kovi('(c)), Derek, Strom, Marcel, Strzys, Yusuke, Suda, Tihomir, Suri('(c)), Mitsunari, Takahashi, Ryuji, Takeishi, Fabrizio, Tavecchio, Petar, Temnikov, Tomislav, Terzic, Masahiro, Teshima, Luca, Tosti, Stefano, Truzzi, Antonio, Tutone, Santiago, Ubach, Juliane van Scherpenberg, Gaia, Vanzo, Monica VAZQUEZ ACOSTA, Sofia, Ventura, Vassil, Verguilov, Carlo Francesco Vigorito, Vincenzo, Vitale, Ievgen, Vovk, Martin, Will, Carolin, Wunderlich, Tokonatsu, Yamamoto, Darko, Zari('(c)), Matteo, Balbo, Thomas, Bretz, Jens, Buss, Laura, Eisenberger, Dorothee, Hildebrand, Roman, Iotov, Adelina, Kalenski, Dominik, Neise, Maximilian, Noethe, Aleksander, Paravac, Vitalii, Sliusar, Roland, Walter, Rasha, Abbasi, Markus, Ackermann, Jenni, Adams, Juanan, Aguilar, Ahlers, M., Maryon, Ahrens, Cyril Martin Alispach, Antonio Augusto Alves Junior, Najia Moureen Binte Amin, Rui, An, Karen, Andeen, Tyler, Anderson, Gisela, Anton, Carlos, Arguelles, Yosuke, Ashida, Spencer, Axani, Xinhua, Bai, Aswathi Balagopal, V., Anastasia Maria Barbano, Barwick, S. W., Benjamin, Bastian, Vedant, Basu, Sebastian, Baur, Bay, R. C., Beatty, J. J., Becker, K. -H., Julia Becker Tjus, Chiara, Bellenghi, Segev, Benzvi, Berley, D., Besson, D. Z., Gary, Binder, Daniel, Bindig, Blaufuss, E., Summer, Blot, Matthias, Boddenberg, Federico, Bontempo, Jurgen, Borowka, Boser, S., Olga, Botner, Jakob, Bottcher, Etienne, Bourbeau, Federica, Bradascio, Braun, J., Stephanie, Bron, Jannes, Brostean-Kaiser, Sally-Ann, Browne, Alexander, Burgman, Ryan, Burley, Raffaela, Busse, Michael, Campana, Erin, Carnie-Bronca, Chujie, Chen, Dmitry, Chirkin, Koun, Choi, Bryanlee, Clark, Kenneth, Clark, Lew, Classen, Alan, Coleman, Gabriel, Collin, Conrad, J. M., Paul, Coppin, Pablo, Correa, Cowen, D. F., Cross, R., Christian, Dappen, Pranav, Dave, Catherine DE CLERCQ, James, Delaunay, Hans, Dembinski, Kunal, Deoskar, Sam De Ridder, Abhishek, Desai, Paolo, Desiati, Krijn de Vries, Gwenhaël de Wasseige, Meike De With, Tyce, Deyoung, Sukeerthi, Dharani, Alejandro, Diaz, Juan Carlos Diaz-Velez, Markus, Dittmer, Hrvoje, Dujmovic, Matt, Dunkman, Michael, Duvernois, Emily, Dvorak, Thomas, Ehrhardt, Philipp, Eller, Ralph, Engel, Hannah, Erpenbeck, John, Evans, Evenson, P. A., Kwok Lung Fan, Fazely, A. R., Sebastian, Fiedlschuster, Aaron, Fienberg, Kirill, Filimonov, Chad, Finley, Leander, Fischer, Derek, B Fox, Anna, Franckowiak, Elizabeth, Friedman, Alexander, Fritz, Philipp, Furst, Gaisser, T. K., Jay, Gallagher, Erik, Ganster, Alfonso, Garcia, Simone, Garrappa, Gerhardt, L., Ava, Ghadimi, Christian, Glaser, Theo, Glauch, Thorsten, Glusenkamp, Goldschmidt, A., Javier, Gonzalez, Sreetama, Goswami, Darren, Grant, Timoth('(e))e, Gr('(e))goire, Spencer, Griswold, Mehmet, Gunduz, Christoph, Günther, Christian, Haack, Allan, Hallgren, Halliday, R., Halve, L., Halzen, F., Martin Ha Minh, Kael, Hanson, John, Hardin, Harnisch, Alexander A., Andreas, Haungs, Simon, Hauser, Dustin, Hebecker, Helbing, K., Felix, Henningsen, Hettinger, Emma C., Stephanie, Hickford, Joshua, Hignight, Colton, Hill, Hill, G. C., Kara, Hoffman, Ruth, Hoffmann, Tobias, Hoinka, Benjamin, Hokanson-Fasig, Hoshina, K., Feifei, Huang, Matthias, Huber, Thomas, Huber, Klas, Hultqvist, Mirco, Hunnefeld, Raamis, Hussain, Seongjin, In, Nad(`(e))ge, Iovine, Aya, Ishihara, Matti, Jansson, George, Japaridze, Minjin, Jeong, Ben, Jones, Donghwa, Kang, Woosik, Kang, Xinyue, Kang, Alexander, Kappes, David, Kappesser, Timo, Karg, Martina, Karl, Karle, A., Katz, U., Kauer, M., Moritz, Kellermann, Kelley, J. L., Ali, Kheirandish, Ken( extquotesingle)ichi Kin, Thomas, Kintscher, Joanna, Kiryluk, Spencer, Klein, Ramesh, Koirala, Hermann, Kolanoski, Tomas, Kontrimas, Lutz, Kopke, Claudio, Kopper, Sandro, Kopper, Koskinen, D. J., Paras, Koundal, Michael, Kovacevich, Marek, Kowalski, Tetiana, Kozynets, Emma, Kun, Naoko, Kurahashi, Neha, Lad, Cristina Lagunas Gualda, Justin, Lanfranchi, Michael, J Larson, Frederik Hermann Lauber, Jeffrey, Lazar, Jiwoong, Lee, Kayla, Leonard, Agnieszka, Leszczy('(n))ska, Yijia, Li, Massimiliano, Lincetto, Qinrui, Liu, Maria, Liubarska, Elisa, Lohfink, Cristian Jesus Lozano Mariscal, Lu, Lu, Francesco, Lucarelli, Andrew, Ludwig, William, Luszczak, Yang, Lyu, Wing Yan Ma, James, Madsen, Kendall, Mahn, Yuya, Makino, Sarah, Mancina, Ioana Codrina Maris, Maruyama, Reina H., Mase, K., Thomas, Mcelroy, Frank, Mcnally, James Vincent Mead, Meagher, K., Andres, Medina, Maximilian, Meier, Stephan, Meighen-Berger, Jessie, Micallef, Daniela, Mockler, Teresa, Montaruli, Roger, Moore, Morse, R., Marjon, Moulai, Richard, Naab, Ryo, Nagai, Uwe, Naumann, Jannis, Necker, Le Viet Nguyen, Hans, Niederhausen, Mehr, Nisa, Sarah, Nowicki, Dave, Nygren, Anna Obertacke Pollmann, Marie, Oehler, Olivas, A., Erin O( extquotesingle)Sullivan, Hershal, Pandya, Daria, Pankova, Nahee, Park, Grant, Parker, Ek Narayan Paudel, Larissa, Paul, Carlos Perez de los Heros, Lilly, Peters, Saskia, Philippen, Damian, Pieloth, Sarah, Pieper, Martin, Pittermann, Pizzuto, A., Plum, M., Yuiry, Popovych, Alessio, Porcelli, Maria Prado Rodriguez, Buford Price, P., Brandom, Pries, Gerald, Przybylski, Christoph, Raab, Amirreza, Raissi, Mohamed, Rameez, Rawlins, K., Immacolata Carmen Rea, Abdul, Rehman, Ren('(e)), Reimann, Giovanni, Renzi, Elisa, Resconi, Simeon, Reusch, Mike, Richman, Benedikt, Riedel, Ella, Roberts, Sally, Robertson, Gerrit, Roellinghoff, Martin, Rongen, Carsten, Rott, Tim, Ruhe, Dirk, Ryckbosch, Devyn Rysewyk Cantu, Ibrahim, Safa, Julian, Saffer, Sebastian Sanchez Herrera, Alexander, Sandrock, Joakim, Sandroos, Marcos, Santander, Subir, Sarkar, Sourav, Sarkar, Maximilian Karl Scharf, Merlin, Schaufel, Harald, Schieler, Sebastian, Schindler, Schlunder, P., Torsten, Schmidt, Austin, Schneider, Judith, Schneider, Schröder, Frank G., Lisa Johanna Schumacher, Georg, Schwefer, Steve, Sclafani, Seckel, D., Surujhdeo, Seunarine, Ankur, Sharma, Shefali, Shefali, Manuel, Silva, Barbara, Skrzypek, Ben, Smithers, Robert, Snihur, Jan, Soedingrekso, Dennis, Soldin, Christian, Spannfellner, Glenn, Spiczak, Christian, Spiering, Juliana, Stachurska, Michael, Stamatikos, Stanev, T., Robert, Stein, Joeran, Stettner, Steuer, A., Stezelberger, T., Timo, Sturwald, Thomas, Stuttard, Sullivan, G. W., Taboada, I., Frederik, Tenholt, Samvel, Ter-Antonyan, Tilav, S., Franziska, Tischbein, Kirsten, Tollefson, Christoph, Tönnis, Simona, Toscano, Delia, Tosi, Alexander, Trettin, Maria, Tselengidou, Chunfai, Tung, Andrea, Turcati, Roxanne, Turcotte, Colin, Turley, Jean Pierre Twagirayezu, Bunheng, Ty, Martin Unland Elorrieta, Nora, Valtonen-Mattila, Justin, Vandenbroucke, Nick van Eijndhoven, David, Vannerom, Jakob van Santen, Stef, Verpoest, Matthias, Vraeghe, Walck, C., Timothyblake, Watson, Chris, Weaver, Philip, Weigel, Andreas, Weindl, Matthew, Weiss, Jan, Weldert, Chris, Wendt, Johannes, Werthebach, Mark, Weyrauch, Nathan, Whitehorn, Wiebusch, C. H., Dawn, Williams, Martin, Wolf, Kurt, Woschnagg, Gerrit, Wrede, Johan, Wulff, Xianwu, Xu, Yiqian, Xu, Juan Pablo Yanez, Yoshida, S., Shiqi, Yu, Tianlu, Yuan, Zelong, Zhang, Weidong, Jin, Hassan, Abdalla, Felix, Aharonian, Faical, Ait-Benkhali, Oguzhan, Anguener, Cornelia, Arcaro, Celine, Armand, Tom, Armstrong, Halim, Ashkar, Michael, Backes, Vardan, Baghmanyan, Victor Barbosa Martins, Anna, Barnacka, Monica, Barnard, Rowan, Batzofin, Yvonne, Becherini, David, Berge, Konrad, Bernlöhr, Baiyang, Bi, Markus, Boettcher, Catherine, Boisson, Julien, Bolmont, Mathieu de Bony, Mischa, Breuhaus, Robert, Brose, Francois, Brun, Tomasz, Bulik, Thomas, Bylund, Floriane, Cangemi, Sami, Caroff, Sabrina, Casanova, Jaqueline, Catalano, Pauline, Chambery, Tej Bahadur Chand, Andrew, Chen, Garret, Cotter, Malgorzata, Curlo, Jean Damascene Mbarubucyeye, Isak Delberth Davids, James, Davies, Justine, Devin, Arache, Djannati-Ataï, Anton, Dmytriiev, Axel, Donath, Victor, Doroshenko, Lente, Dreyer, Louis Du Plessis, Connor, Duffy, Kathrin, Egberts, Sabrina, Einecke, Gabriel, Emery, Jean-Pierre, Ernenwein, Steven, Fegan, Kirsty, Feijen, Armand, Fiasson, Gaëtan Fichet de Clairfontaine, Gerard, Fontaine, Lott, Frans, Matthias, Fuessling, Stefan, Funk, Stefano, Gabici, Yves, Gallant, Shahede, Ghafourizade, Gianluca, Giavitto, Luca, Giunti, Dorit, Glawion, Jean-Francois, Glicenstein, Marie-H('(e))l(`(e))ne, Grondin, Sumari, Hattingh, Maria, Haupt, German, Hermann, Jim, Hinton, Werner, Hofmann, Clemens, Hoischen, Tim, Holch, Markus, Holler, Dieter, Horns, Zhiqiu, Huang, David, Huber, Mario, Hörbe, Marek, Jamrozy, Felix, Jankowsky, Vikas, Joshi, Ira, Jung, Eli, Kasai, Krzysztof, Katarzynski, Ul(`(i)), Katz, Dmitry, Khangulyan, Bruno, Khelifi, Stefan, Klepser, Wlodek, Kluzniak, Nukri, Komin, Ruslan, Konno, Karl, Kosack, Dmitriy, Kostunin, Michael, Kreter, Ga( (s))per Kukec Mezek, Anu, Kundu, Giovanni, Lamanna, S('(e))bastien Le Stum, Anne, Lemiere, Marianne, Lemoine-Goumard, Jean-Philippe, Lenain, Fabian, Leuschner, Christelle, Levy, Thomas, Lohse, Anna, Luashvili, Iryna, Lypova, Jonathan, Mackey, Jhilik, Majumdar, Denys, Malyshev, Dmitry, Malyshev, Vincent, Marandon, Paolo, Marchegiani, Alexandre, Marcowith, Arnaud, Mares, Guillem Marti( extquotesingle)i-Devesa, Ramin, Marx, Gilles, Maurin, Pieter, Meintjes, Manuel, Meyer, Alison, Mitchell, Rafal, Moderski, Lars, Mohrmann, Alessandro, Montanari, Chris, Moore, Paul, Morris, Emmanuel, Moulin, Jacques, Muller, Thomas, Murach, Kaori, Nakashima, Mathieu Naurois (de), Amid, Nayerhoda, Hambeleleni, Ndiyavala, Jacek, Niemiec, Angel, Noel, Paul O( extquotesingle)Brien, Laenita Lorraine Oberholzer, Stefan, Ohm, Laura, Olivera-Nieto, Emma Ona-Wilhelmi (de), Michal, Ostrowski, Sebastian, Panny, Michael, Panter, Dan, Parsons, Giada, Peron, Santiago, Pita, Vincent, Poireau, Dmitry, Prokhorov, Heike, Prokoph, Gerd, Puehlhofer, Michael, Punch, Andreas, Quirrenbach, Patrick, Reichherzer, Anita, Reimer, Olaf, Reimer, Quentin, Remy, Matthieu, Renaud, Brian, Reville, Frank, Rieger, Carlo, Romoli, Gavin, Rowell, Bronislaw, Rudak, Hector Rueda Ricarte, Edna Ruiz Velasco, Vardan, Sahakian, Simon, Sailer, Heiko, Salzmann, David, Sanchez, Andrea, Santangelo, Manami, Sasaki, Johannes, Schaefer, Hester, Schutte, Ullrich, Schwanke, Fabian, Schüssler, Mohanraj, Senniappan, Albert, Seyffert, Shapopi, Jimmy N. S., Kleopas, Shiningayamwe, Rachel, Simoni, Atreyee, Sinha, Helene, Sol, Hugh, Spackman, Andreas, Specovius, Samuel Timothy Spencer, Marion, Spir-Jacob, Lukasz, Stawarz, Riaan, Steenkamp, Christian, Stegmann, Simon, Steinmassl, Constantin, Steppa, Lei, Sun, Tadayuki, Takahashi, Takaaki, Tanaka, Thomas, Tavernier, Andrew, Taylor, Regis, Terrier, Hannes, Thiersen, Charles, Thorpe-Morgan, Martin, Tluczykont, Lenka, Tomankova, Michelle, Tsirou, Naomi, Tsuji, Richard, Tuffs, Yasunobu, Uchiyama, Johann van der Walt, Christopher van Eldik, Carlo van Rensburg, Brian van Soelen, George, Vasileiadis, Johannes, Veh, Christo, Venter, Pascal, Vincent, Jacco, Vink, Völk, Heinrich J., Stefan, Wagner, Jason John Watson, Felix, Werner, Richard, White, Alicja, Wierzcholska, Yu Wun Wong, Hend, Yassin, Anke, Yusafzai, Michael, Zacharias, Roberta, Zanin, Davit, Zargaryan, Andrzej, Zdziarski, Andreas, Zech, Sylvia, Zhu, Andreas, Zmija, Samuel, Zouari, Natalia, Zywucka, The FACT Collaboration, The H.E.S.S. Collaboration, The IceCube Collaboration, The MAGIC Collaboration, The VERITAS Collaboration, and Współautorami artykułu są członkowie Magic Collaboration, IceCube Collaboration, FACT Collaboration, H.E.S.S. Collaboration, VERITAS Collaboration w liczbie 808

Subjects
Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Point source, Astrophysics::High Energy Astrophysical Phenomena, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, IACT, Astrophysics, law.invention, High Energy Physics - Experiment, Telescope, High Energy Physics - Experiment (hep-ex), law, HESS - Abteilung Hinton, ddc:530, High Energy Physics::Experiment, MAGIC (telescope), Neutrino, Blazar, Astrophysics - High Energy Astrophysical Phenomena, Cherenkov radiation
Abstract

The realtime follow-up of neutrino events is a promising approach to search for astrophysical neutrino sources. It has so far provided compelling evidence for a neutrino point source: the flaring gamma-ray blazar TXS 0506+056 observed in coincidence with the high-energy neutrino IceCube-170922A detected by IceCube. The detection of very-high-energy gamma rays (VHE, $\mathrm{E} > 100\,\mathrm{GeV}$) from this source helped establish the coincidence and constrained the modeling of the blazar emission at the time of the IceCube event. The four major imaging atmospheric Cherenkov telescope arrays (IACTs) - FACT, H.E.S.S., MAGIC, and VERITAS - operate an active follow-up program of target-of-opportunity observations of neutrino alerts sent by IceCube. This program has two main components. One are the observations of known gamma-ray sources around which a cluster of candidate neutrino events has been identified by IceCube (Gamma-ray Follow-Up, GFU). Second one is the follow-up of single high-energy neutrino candidate events of potential astrophysical origin such as IceCube-170922A. GFU has been recently upgraded by IceCube in collaboration with the IACT groups. We present here recent results from the IACT follow-up programs of IceCube neutrino alerts and a description of the upgraded IceCube GFU system., Presented at the 37th International Cosmic Ray Conference (ICRC 2021). See arXiv:2107.06966 for all IceCube contributions. See arXiv:2108.05257 for all H.E.S.S. contributions

Published
2022

22. Multicenter Clinical Evaluation of ETEST Plazomicin (PLZ) for Susceptibility Testing of Enterobacterales

Author

Michael Kresken, Gilles Zambardi, Christopher L. Emery, Marion Pompilio, Alex van Belkum, Yun X Ying, Diane Halimi, Dominique Dechaume, Tom Armstrong, and Laurine S Blanchard

Subjects
Microbiology (medical), Susceptibility testing, medicine.medical_specialty, Brand names, medicine.drug_class, business.industry, Antibiotics, Aminoglycoside, Microbial Sensitivity Tests, Plazomicin, Anti-Bacterial Agents, Food and drug administration, chemistry.chemical_compound, Enterobacteriaceae, chemistry, Disk Diffusion Antimicrobial Tests, Internal medicine, Enterobacterales, Pseudomonas aeruginosa, Sisomicin, medicine, Humans, business, Clinical evaluation
Abstract

Plazomicin (PLZ), brand name ZEMDRI (Cipla Therapeutics), is a novel aminoglycoside antibiotic approved by the US Food and Drug Administration (FDA) for treatment of complicated urinary tract infections including pyelonephritis. ETEST® is a gradient diffusion method that represents an alternative to the more laborious broth micro-dilution (BMD) method for performing antimicrobial susceptibility testing (AST). A multi-center evaluation of the performance of the new ETEST® PLZ (bioMerieux) was conducted in comparison with BMD following FDA and International Standards Organization (ISO) recommendations using FDA-defined breakpoints. Clinical isolates of Enterobacterales (n=598) were included. Fifty-three isolates were resistant to PLZ according to BMD. Overall, the ETEST® PLZ demonstrated 99.0% Essential Agreement (EA), 92.8% Category Agreement (CA), 1.9% Very Major Errors (VME), 0% Major Errors (ME) and 7.0% minor Errors (mE) with both clinical and challenge isolates of Enterobacterales. The VME was found for a single Serratia marcescens strain. Individual species demonstrated EA rates ≥ 90%. In conclusion, we report that ETEST® PLZ represents an accurate tool for performing PLZ AST of Enterobacterales.

Published
2022
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23. Limits on primordial black hole evaporation from H.E.S.S. observations

Author

Hannah Dalgleish, Michael Punch, Samuel Timothy Spencer, Stefan Ohm, Stefan Klepser, M. Fuessling, Constantin Steppa, Markus Holler, Q. Remy, Felix Jankowsky, Alessandro Montanari, Stefano Gabici, Felix Aharonian, Dan Parsons, S. Steinmassl, Sami Caroff, Gianluca Giavitto, Sumari Hattingh, Takaaki Tanaka, Ramin Marx, M. Panter, Laura Olivera-Nieto, A. Yusafzai, M.-H. Grondin, U. Katz, N. Zywucka, Alison Mitchell, Krzysztof Katarzynski, Catherine Boisson, J. Bolmont, Victor Barbosa Martins, Ullrich Schwanke, P. T. O'Brien, Jhilik Majumdar, Markus Boettcher, Faical Ait-Benkhali, Dieter Horns, C. Arcaro, Floriane Cangemi, V. Poireau, Jimmy N.S. Shapopi, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Clemens Hoischen, A. A. Zdziarski, Carlo van Rensburg, Albert Seyffert, Justine Devin, Gavin Rowell, G. Vasileiadis, Johann van der Walt, V. Sahakian, K. Nakashima, Sébastien Le Stum, Denys Malyshev, Regis Terrier, Mathieu Bony, Oguzhan Anguener, Tadayuki Takahashi, Victor Doroshenko, L. Giunti, E. Kasai, Vikas Joshi, Carlo Romoli, Yves Gallant, Frank M. Rieger, Atreyee Sinha, Kirsty Feijen, K. Bernloehr, Samuel Zouari, Andreas Zmija, Christian Stegmann, Michal Ostrowski, Stefan Wagner, J.-P. Lenain, Christo Venter, Hugh Spackman, S. J. Fegan, Andreas Zech, Jason John Watson, Heinrich J. Völk, Jean-Pierre Ernenwein, M. Lemoine-Goumard, Yasunobu Uchiyama, Matthieu Renaud, Mohanraj Senniappan, L. Mohrmann, Lukasz Stawarz, Anton Dmytriiev, German Hermann, Paul Morris, Johannes Veh, Brian Reville, Connor Duffy, James Davies, Stefan Funk, Alicja Wierzcholska, Michelle Tsirou, Michael Kreter, Anne Lemiere, Rachel Simoni, Andreas Quirrenbach, Manami Sasaki, R. J. Tuffs, B. Bi, Guillem Marti'i-Devesa, Jacek Niemiec, M. Hörbe, Andreas Specovius, Andrea Santangelo, Mischa Breuhaus, Pauline Chambery, Olaf Reimer, Michael Zacharias, Emma Ona-Wilhelmi, Martin Tluczykont, Yu Wun Wong, Robert Brose, Michael Backes, Francois Brun, Thomas Lohse, Marek Jamrozy, Jaqueline Catalano, T. Chand, Thomas Murach, Arache Djannati-Ataï, P. Reichherzer, Gašper Kukec Mezek, P. Vincent, Anita Reimer, Laenita Lorraine Oberholzer, Nukri Komin, G. Lamanna, Helene Sol, R. Konno, Monica Barnard, Anna Barnacka, Heiko Salzmann, G. Peron, Vincent Marandon, Hannes Thiersen, Andrew Taylor, Garret Cotter, Tim Holch, Dmitriy Kostunin, Hend Yassin, Isak Delberth Davids, Manuel Meyer, A. Fiasson, Tom Armstrong, Celine Armand, Johannes Schaefer, Roberta Zanin, Zhiqiu Huang, Paolo Marchegiani, Vardan Baghmanyan, Naomi Tsuji, Mathieu Naurois, D. A. Prokhorov, K. Kosack, Gerard Fontaine, Brian van Soelen, David Sanchez, Santiago Pita, Werner Hofmann, Hester Schutte, Hambeleleni Ndiyavala, Gilles Maurin, J. F. Glicenstein, Thomas Tavernier, Kleopas Shiningayamwe, Bruno Khelifi, Edna Ruiz Velasco, Lenka Tomankova, Sabrina Einecke, Iryna Lypova, Yvonne Becherini, Hassan Abdalla, C. Levy, Sylvia Zhu, P. J. Meintjes, David Berge, Richard White, Jacco Vink, Heike Prokoph, Marion Spir-Jacob, David Huber, Amid Nayerhoda, Maria Haupt, Sabrina Casanova, Halim Ashkar, Fabian Leuschner, B. Rudak, Kathrin Egberts, Christopher van Eldik, Rafal Moderski, Anna Luashvili, Lott Frans, Jim Hinton, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Angel Noel, Jonathan Mackey, C. Moore, Dorit Glawion, Davit Zargaryan, Tomasz Bulik, Malgorzata Curlo, Lente Dreyer, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Riaan Steenkamp, Fabian Schüssler, Emmanuel Moulin, Thomas Bylund, Rowan Batzofin, Jacques Muller, Hector Rueda Ricarte, Louis Du Plessis, Anu Kundu, D. Malyshev, Ira Jung, Sebastian Panny, Gerd Puehlhofer, Lei Sun, Alexandre Marcowith, Felix Werner, and Arnaud Mares

Subjects
Physics, Astrophysics::High Energy Astrophysical Phenomena, media_common.quotation_subject, Gravitational collapse, Evaporation, Order (ring theory), Primordial black hole, Astrophysics, Radiation, Universe, media_common, Hawking radiation
Abstract

Primordial Black Holes are expected to be formed in the early Universe by the gravitational collapse of overdense regions, among other mechanisms. They are also expected to loose their mass over time by the Hawking radiation process. As the rates of this radiation increase with temperature, the PBH evaporation should result in a violent explosion. The current upper limits on explosion rates are on the order of 10$^{4}$ − 10$^{5}$pc$^{-3}$yr$^{-1}$. In this contribution we'll present the results of a search for TeV γ-ray burst within timescale of few seconds, using nearly 5000 hours of H.E.S.S. data. The search algorithm and statistical estimation strategy will be presented as well as cosmological implications of this measurement.

Published
2022

24. Detection of new Extreme BL Lac objects with H.E.S.S. and Swift XRT

Author

Angel Priyana Noel, Hassan Abdalla, Felix Aharonian, Faical Ait-Benkhali, Oguzhan Anguener, Cornelia Arcaro, Celine Armand, Tom Armstrong, Halim Ashkar, Michael Backes, Vardan Baghmanyan, Victor Barbosa Martins, Anna Barnacka, Monica Barnard, Rowan William Batzofin, Yvonne Becherini, David Berge, Konrad Bernloehr, Baiyang Bi, Markus Böttcher, Catherine Boisson, Julien Bolmont, Mathieu Bony (de), Mischa Breuhaus, Robert Brose, Francois Brun, Tomasz Bulik, Thomas Bylund, Floriane Cangemi, Sami Caroff, Sabrina Casanova, Jaqueline Catalano, Pauline Chambery, Tej Bahadur Chand, Andrew Chen, Garret Cotter, Malgorzata Curlo, Hannah Dalgleish, Jean Damascene Mbarubucyeye, Isak Delberth Davids, James Davies, Justine Devin, Arache Djannati-Ataï, Anton Dmytriev, Axel Donath, Victor Doroshenko, Lente Dreyer, Louis Du Plessis, Connor Duffy, Kathrin Egberts, Sabrina Einecke, Jean-Pierre ERNENWEIN, Steven Fegan, Kirsty Feijen, Armand Fiasson, Gaëtan Fichet de Clairfontaine, Gerard Fontaine, Lott Frans, Matthias Fuessling, Stefan Funk, Stefano Gabici, Yves Gallant, Gianluca Giavitto, Luca Giunti, Dorit Glawion, Jean-Francois Glicenstein, Marie-Hélène Grondin, Sumari Hattingh, Maria Haupt, German HERMANN, Jim Hinton, Werner Hofmann, Clemens Hoischen, Tim Holch, Markus Holler, Dieter Horns, Zhi-Qiu Huang, David Huber, Mario Hörbe, Marek Jamrozy, Felix Jankowsky, Vikas Joshi, Ira JUNG, Eli Kasai, Krzysztof Katarzynski, Ulì Katz, Dmitry Khangulyan, Bruno Khelifi, Stefan Klepser, Wlodek Kluzniak, Nukri Komin, Ruslan Konno, Karl Kosack, Dmitriy Kostunin, Michael Kreter, Gašper Kukec Mezek, Anu Kundu, Giovanni Lamanna, Sebastien Le Stum, Anne Lemiere, Marianne Lemoine-Goumard, Jean-Philippe Lenain, Fabian Leuschner, Christelle Levy, Thomas Lohse, Anna Luashvili, Iryna Lypova, Jonathan Mackey, Jhilik Majumdar, Denys Malyshev, Dmitry Malyshev, Vincent Marandon, Paolo Marchegiani, Alexandre Marcowith, Arnaud Mares, Guillem Martí-Devesa, Ramin Marx, Gilles Maurin, Pieter Meintjes, Manuel Meyer, Alison Mitchell, Rafal Moderski, Lars Mohrmann, Alessandro Montanari, Chris Moore, Paul Morris, Emmanuel Moulin, Jacques Muller, Thomas Murach, Kaori Nakashima, Mathieu Naurois (de), Amid Nayerhoda, Hambeleleni Davids, Jacek Niemiec, Paul O'Brien, Laenita Lorraine Oberholzer, Stefan Ohm, Laura Olivera-Nieto, Emma Ona-Wilhelmi (de), Michal Ostrowski, Sebastian Panny, Michael Panter, Dan Parsons, Giada Peron, Santiago Pita, Vincent Poireau, Dmitry A Prokhorov, Heike Prokoph, Gerd PUEHLHOFER, Michael Punch, Andreas Quirrenbach, Patrick Reichherzer, Anita Reimer, Olaf Reimer, Quentin Remy, Matthieu Renaud, Brian Reville, Frank Rieger, Carlo Romoli, Gavin P Rowell, Bronislaw Rudak, Hector Rueda Ricarte, Edna Ruiz Velasco, Vardan Sahakian, Simon Sailer, Heiko Salzmann, David Sanchez, Andrea Santangelo, Manami Sasaki, Johannes Schaefer, Hester Schutte, Ullrich Schwanke, Fabian Schüssler, Mohanraj Senniappan, Albert Seyffert, Jimmy N.S. Shapopi, Kleopas Shiningayamwe, Rachel Simoni, Atreyee Sinha, Helene Sol, Hugh Spackman, Andreas Specovius, Samuel Timothy Spencer, Marion Spir-Jacob, Lukasz Stawarz, Riaan Steenkamp, Christian Stegmann, Simon Steinmassl, Constantin Steppa, Lei Sun, Tadayuki Takahashi, Takaaki Tanaka, Thomas Tavernier, Andrew Taylor, Regis Terrier, Hannes Thiersen, Charles Thorpe-Morgan, Martin Tluczykont, Lenka Tomankova, Michelle Tsirou, Naomi Tsuji, Richard Tuffs, Yasunobu Uchiyama, Johann van der Walt, Christopher van Eldik, Carlo van Rensburg, Brian van Soelen, George Vasileiadis, Johannes Veh, Christo Venter, Pascal Vincent, Jacco Vink, Heinrich J. Völk, Stefan Wagner, Jason John Watson, Felix Werner, Richard White, Alicja Wierzcholska, Yu Wun Wong, Hend Mahmoud Yassin, Anke Yusafzai, Michael Zacharias, Roberta Zanin, Davit Zargaryan, Andrzej Zdziarski, Andreas Zech, Sylvia Zhu, Andreas Zmija, Samuel Zouari, Natalia Żywucka, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), H.E.S.S., and Fermi-LAT

Subjects
accelerator, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, gamma ray: absorption, VHE, law.invention, blazar, X-ray, particle: acceleration, law, HESS, synchrotron, Radiative transfer, TeV, High Energy Stereoscopic System, 10. No inequality, Absorption (electromagnetic radiation), Blazar, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Range (particle radiation), energy: high, redshift, Redshift, Synchrotron, Particle acceleration, spectral, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

Extreme high synchrotron peaked blazars (EHBLs) are amongst the most powerful accelerators found in nature. Usually the synchrotron peak frequency of an EHBL is above $10^{17}\,$Hz, i.e., lies in the range of medium to hard X-rays making them ideal sources to study particle acceleration and radiative processes. EHBL objects are commonly observed at energies beyond several TeV, making them also powerful probes of gamma-ray absorption in the intergalactic medium. During the last decade, several attempts have been made to increase the number of EHBL detected at TeV energies and probe their spectral characteristics. Here we report new detections of EHBLs in the TeV energy regime, each at a redshift of less than 0.2, by the High Energy Stereoscopic System (H.E.S.S.). Also, we report on X-ray observations of these EHBLs candidates with Swift XRT. In conjunction with the very high energy observations, this allows us to probe the radiation mechanisms and the underlying particle acceleration processes., Proceedings of the 37th International Cosmic Ray Conference (ICRC 2021)

Published
2022
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25. H.E.S.S. ToO program on nearby core-collapse Supernovae : search for very-high energy γ-ray emission towards the SN candidate AT2019krl in M74

Author

German Hermann, Paul Morris, Tadayuki Takahashi, Victor Doroshenko, Ramin Marx, Marek Jamrozy, E. Kasai, Jean-Pierre Ernenwein, Helene Sol, M. Panter, Denys Malyshev, U. Katz, Stefan Klepser, Alessandro Montanari, Markus Boettcher, Jacek Niemiec, Johannes Veh, Olaf Reimer, Regis Terrier, Robert Brose, M.-H. Grondin, Paolo Marchegiani, Matthieu Renaud, Stefan Ohm, Faical Ait-Benkhali, Thomas Murach, Carlo Romoli, Frank M. Rieger, Constantin Steppa, T. Chand, Laura Olivera-Nieto, Mohanraj Senniappan, G. Peron, Stefano Gabici, A. Yusafzai, Garret Cotter, Zhiqiu Huang, D. A. Prokhorov, K. Kosack, Ullrich Schwanke, Johannes Schaefer, Sébastien Le Stum, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Arache Djannati-Ataï, Hannah Dalgleish, P. Reichherzer, Santiago Pita, Justine Devin, Hambeleleni Ndiyavala, Martin Tluczykont, Maria Haupt, J. Bolmont, G. Lamanna, M. Hörbe, Albert Seyffert, Isak Delberth Davids, A. Fiasson, Rachel Simoni, Roberta Zanin, P. T. O'Brien, Samuel Timothy Spencer, Brian Reville, Connor Duffy, C. Levy, James Davies, Dmitriy Kostunin, Gašper Kukec Mezek, Michal Ostrowski, Michael Backes, R. J. Tuffs, B. Bi, J.-P. Lenain, Jaqueline Catalano, Hugh Spackman, Dan Parsons, Halim Ashkar, Fabian Leuschner, Atreyee Sinha, Mathieu Bony, Oguzhan Anguener, S. J. Fegan, Brian van Soelen, N. Zywucka, Mischa Breuhaus, Pauline Chambery, Anton Dmytriiev, Laenita Lorraine Oberholzer, K. Nakashima, Christo Venter, Hend Yassin, Tim Holch, Kirsty Feijen, M. Fuessling, R. Konno, Manami Sasaki, Anna Barnacka, Markus Holler, Q. Remy, Felix Jankowsky, Manuel Meyer, Francois Brun, Andrew Taylor, Vikas Joshi, K. Bernloehr, P. Vincent, Anita Reimer, Krzysztof Katarzynski, Naomi Tsuji, Stefan Funk, Andrea Santangelo, Alicja Wierzcholska, Mathieu Naurois, Thomas Tavernier, Catherine Boisson, Floriane Cangemi, Gerard Fontaine, Anne Lemiere, Felix Aharonian, B. Rudak, V. Poireau, Kathrin Egberts, Jimmy N.S. Shapopi, S. Steinmassl, Sami Caroff, Heiko Salzmann, Hester Schutte, Jhilik Majumdar, Heinrich J. Völk, Andreas Specovius, Lukasz Stawarz, G. Vasileiadis, Richard White, Victor Barbosa Martins, Andreas Zmija, Jacco Vink, M. Lemoine-Goumard, Yu Wun Wong, Alison Mitchell, Jason John Watson, Celine Armand, David Huber, Andreas Quirrenbach, Sabrina Casanova, Emma Ona-Wilhelmi, Michael Kreter, Vincent Marandon, Hannes Thiersen, Guillem Marti'i-Devesa, Nukri Komin, Tom Armstrong, L. Giunti, Vardan Baghmanyan, Michael Zacharias, Christian Stegmann, Thomas Lohse, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, L. Mohrmann, Carlo van Rensburg, C. Arcaro, Christopher van Eldik, Samuel Zouari, Rafal Moderski, V. Sahakian, David Sanchez, Gavin Rowell, Michelle Tsirou, Yves Gallant, Kleopas Shiningayamwe, Werner Hofmann, Sabrina Einecke, Edna Ruiz Velasco, Iryna Lypova, Yvonne Becherini, Lenka Tomankova, Heike Prokoph, Monica Barnard, Marion Spir-Jacob, Amid Nayerhoda, Gilles Maurin, J. F. Glicenstein, Sylvia Zhu, P. J. Meintjes, David Berge, Bruno Khelifi, Jim Hinton, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Hassan Abdalla, Davit Zargaryan, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Fabian Schüssler, Emmanuel Moulin, Gianluca Giavitto, Ira Jung, Sebastian Panny, Louis Du Plessis, Sumari Hattingh, Gerd Puehlhofer, Lei Sun, Thomas Bylund, Rowan Batzofin, Takaaki Tanaka, Alexandre Marcowith, Felix Werner, Jacques Muller, Anna Luashvili, Stuart Ryder, Lott Frans, Arnaud Mares, Hector Rueda Ricarte, Angel Noel, Jonathan Mackey, C. Moore, Dorit Glawion, D. Malyshev, Tomasz Bulik, Riaan Steenkamp, Malgorzata Curlo, Lente Dreyer, Anu Kundu, Michael Punch, Dieter Horns, Clemens Hoischen, A. A. Zdziarski, and Johann van der Walt

Subjects
Core (optical fiber), Physics, Supernova, High energy, Gamma ray, Collapse (topology), Astrophysics
Abstract

While the youngest known supernova remnants (SNRs), such as Cassiopeia A (Cas A), have been proven to be able to accelerate cosmic rays (CRs) only up to ∼ 10$^{14}$ eV at their present evolutionary stages, recent studies have shown that particle energies larger than a few PeV (10$^{15}$ eV) could be reached during the early stages of a core-collapse Supernova (cc-SN), when the high-velocity forward shock expands into the dense circumstellar medium (CSM) shaped by the stellar progenitor wind. Such environments, in particular the type IIn SNe whose progenitors may exhibit mass loss rates as high as 10$^{-2}$ M$_{\bigodot}$ yr$^{-1}$, could thus lead to γ-ray emission from $\pi ^{0}$ decay in hadronic interactions, potentially detectable with current Cherenkov telescopes at very-high energies. Such a detection would provide direct evidence for efficient acceleration of CR protons/nuclei in supernovae, and hence new insights on the long-standing issue of the origin of Galactic Cosmic Rays. In that context, the High Energy Stereoscopic System (H.E.S.S.) has been carrying out a Target of Opportunity program since 2016 to search for such an early very-high-energy γ-ray emission towards nearby core-collapse supernovae and supernova candidates (up to ∼ 10 Mpc), within a few weeks after discovery. After giving an overview of this H.E.S.S. Target of Opportunity program, we present the results obtained from the July 2019 observations towards the transient AT2019krl, originally classified as a type IIn supernova, which occurred in the galaxy M74 at ∼ 9.8 Mpc. Although its nature still remains unclear, the derived H.E.S.S. constraints on this transient are placed in the general context of the expected VHE γ-ray emission from core-collapse supernovae.

Published
2022

26. JMM Profile: Carbapenems: a broad-spectrum antibiotic

Author

Tom Armstrong, Samuel Jacob Fenn, and Kim R. Hardie

Subjects
Microbiology (medical), polycyclic compounds, General Medicine, biochemical phenomena, metabolism, and nutrition, Microbiology
Abstract

Carbapenems are potent members of the β-lactam family that inhibit bacterial cell-wall biosynthesis inhibitors . They are highly effective against Gram-negative and Gram-positive drug-resistant infections . As such, carbapenems are typically reserved as an antibiotic of last resort. The WHO lists meropenem as an essential medicine. Nausea and vomiting are reported in ≤20% of carbapenem recipients, with 1.5% suffering seizures. Enzymatic hydrolysis of the β-lactam ring is the main driver of clinical resistance. These enzymes can be classified as Class A, B and D. Classes A and D are serine β-lactamases, whereas Class B rely on metal-mediated hydrolysis, typically through zinc.

Published
2021
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27. P-P44 Clinical outcomes of consecutive patients undergoing distal pancreatectomy over the last decade at a high volume tertiary pancreatic surgery unit

Author

Bhavik Patel, Richard Fristedt, Zaed Hamady, Arjun Takhar, Tom Armstrong, Mohammad Abu Hilal, Dimitrios Karavias, and Ali Arshad

Subjects
Surgery
Abstract

Background Distal pancreatectomy (DP) enables resection of lesions in the body and tail of the pancreas. Over the past decade, the Laparoscopic approach has become frequently employed. There remains scarce outcome data available following laparoscopic distal pancreatectomy over a long time period from high volume centres. Postoperative pancreatic fistula (POPF) remains the main source of morbidity and mortality after DP. The causes of POPF are multifactorial and poorly understood. The optimal method of pancreatic stump closure is still debated with variation in clinical practice. Methods All patients that underwent distal pancreatectomy at a UK tertiary pancreatic surgery centre between January 2011 and January 2021 were identified and clinical outcomes examined. Patients undergoing completion pancreatectomies were excluded. Clinical, pathological and surgical data for the included patients was retrospectively collected from the electronic patient record. Clinically significant POPF was defined as Grade B or C as per the ISGPF guidelines. For stapled stump closure, the Compression Index (CI) was calculated using closed staple height (mm) divided by the pancreatic thickness (mm). High and low CI was defined around the median. Results 233 patients (n = 90 open and n = 143 laparoscopic) were included in the final analysis. The laparoscopic approach was associated with comparable morbidity and significantly lower blood loss, shorter operative time and shorter length of stay. There were no significant differences in age, sex, final histology, closure technique, or ASA Score of 3 or more amongst patients with clinically relevant POPF (CR-POPF). The POPF group had a significantly higher BMI, drain duration and readmission rate. CI data was available for 78 cases (range 0.04-0.21). There was no significant difference in low vs high CI for patients with CR-POPF. Conclusions Laparoscopic distal pancreatectomy is associated with favourable clinical outcomes in this series. Stapled vs sutured closure of the pancreatic stump offered equivocal outcomes with relation to POPF. POPF continues to have a significant impact on a clinical recovery as evident from longer drain duration and high readmission rates. Further research is required to try to establish methods for reducing the incidence of POPF after distal pancreatectomy.

Published
2021
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28. TeV Emission of Galactic Plane Sources with HAWC and H.E.S.S

Author

Nicola Omodei, Sebastian Panny, A. Sandoval, Q. Piel, S. Raab, Arturo Iriarte, Kirsty Feijen, R. D. Parsons, Michael Newbold, J. Zorn, Michael Schneider, Fernando Garfias, D. Huber, Christo Venter, Jacek Niemiec, Arnaud Mares, Frank M. Rieger, Thomas Weisgarber, A. Dmytriiev, Olaf Reimer, A. Zech, E. Ruiz-Velasco, Thomas Bylund, Y. A. Gallant, David Sánchez, R. López-Coto, Jorge Cotzomi, Jacques Muller, H. León Vargas, Alison Peisker, Justine Devin, Thomas Murach, P. Morris, Harm Schoorlemmer, Jonathan Mackey, Andrea Albert, Samuel Zouari, Pascal Vincent, M. Zacharias, Stefan Ohm, S. Pita, Tadayuki Takahashi, Gilgamesh Luis-Raya, A. Yusafzai, Andreas Quirrenbach, Samuel Timothy Spencer, Stefano Gabici, Regis Terrier, Victor Doroshenko, L. Nellen, Włodek Kluźniak, R. Noriega-Papaqui, E. Kasai, C. Moore, L. Oakes, J. Bolmont, Michal Ostrowski, J.-P. Lenain, Pooja Surajbali, William H. Lee, L. Olivera-Nieto, E. Moulin, Tomasz Bulik, Rhiannon Turner, Lente Dreyer, O. Martinez, Stefan Klepser, Alessandro Montanari, D. J. van der Walt, Fernando Ureña-Mena, J. P. Harding, César Alvarez, Michael DuVernois, A.M. Taylor, J. C. Arteaga-Velézquez, Connor Duffy, Davit Zargaryan, R. J. White, Stefan Funk, Alicja Wierzcholska, Dmitriy Kostunin, J. Damascene Mbarubucyeye, R. Rauth, Maria Magdalena González, Kristi Engel, A. Galván-Gámez, Christoph Deil, Krzysztof Katarzynski, F. Eichhorn, Mohanraj Senniappan, E. Moreno, Michael Punch, Axel Donath, B. Hona, A. W. Chen, S. Steinmassl, Sami Caroff, Domenico Tiziani, D. Malyshev, Catherine Boisson, M. Panter, Mora Durocher, U. Katz, Pedro Miranda-Romagnoli, C. Arcaro, H. Zhou, Michael Backes, S. Coutiño de León, Ernesto Belmont-Moreno, M. de Bony de Lavergne, R. Brose, Petra Hüntemeyer, C. Levy, Francois Brun, R. J. Tuffs, B. Bi, Andreas Specovius, Joachim Hahn, K. P. Arunbabu, Riaan Steenkamp, Gavin Rowell, P. Reichherzer, James E. M. Watson, M. Bryan, E. de Oña Wilhelmi, Łukasz Stawarz, C. van Rensburg, Pierre Brun, Brenda Dingus, V. Marandon, J. A. Morales-Soto, M. Büchele, H. Prokoph, C. De León, A. Marcowith, V. Baghmanyan, J. Schäfer, Nu. Komin, Tim Holch, Q. Remy, H. M. Schutte, Isak Delberth Davids, A. Fiasson, Jean-Pierre Ernenwein, Hassan Abdalla, S. Hernandez, Jim Hinton, V. Sahakian, E. De la Fuente, F. Werner, Mischa Breuhaus, Luis Villaseñor, Yu Wun Wong, Hambeleleni Ndiyavala, D. Avila Rojas, G. Lamanna, K. S. Caballero-Mora, Roberta Zanin, G. Emery, Halim Ashkar, Fabian Leuschner, Heiko Salzmann, A. S. Seyffert, Kwok Lung Fan, M. Hörbe, T. Tavernier, Nissim Illich Fraija, P. T. O'Brien, Johannes Veh, S. Sailer, Dmitry Khangulyan, Gilles Maurin, S. J. Fegan, A. Djannati-Ataï, D. Jankowsky, J. Dyks, Celine Armand, M. Füßling, R. Marx, Dieter Horns, M. Tluczykont, F. Ait Benkhali, J. F. Glicenstein, M. U. Nisa, Marek Jamrozy, Clemens Hoischen, A. A. Zdziarski, A. Jardin-Blicq, E. O. Angüner, R. Diaz Hernandez, N. Shafi, Natalia Żywucka, M. de Naurois, Andrea Santangelo, K. Malone, Gwenael Giacinti, L. Sun, M.-H. Grondin, D. Garcia, M. Seglar-Arroyo, B. Khélifi, A. J. Smith, T. Capistrán, B. van Soelen, G. Hermann, Anna Barnacka, D. Gottschall, Anne Lemiere, B. Rudak, Markus Böttcher, K. Tollefson, Jhilik Majumdar, Helene Sol, T. Chand, C. Brisbois, Andreas Zmija, Tom Armstrong, Elijah Willox, Carlo Romoli, Alison Mitchell, R. Torres-Escobedo, Atreyee Sinha, Manuel Meyer, I. Martinez-Castellanos, Zorawar Wadiasingh, A. Priyana Noel, V. Barbosa Martins, C. van Eldik, M. Lemoine-Goumard, M. Tsirou, Michael Kreter, Anna Lia Longinotti, F. Schüssler, Dezhi Huang, Jose Andres Garcia-Gonzalez, Werner Hofmann, Monica Barnard, Juan Carlos Diaz-Velez, V. Poireau, Jimmy N.S. Shapopi, K. Nakashima, José Serna-Franco, G. Peron, Garret Cotter, Jacco Vink, A. Carraminana, Umberto Cotti, Jim Davies, M. A. Kastendieck, Thomas Lohse, K. Kosack, Paolo Marchegiani, Konrad Bernlöhr, Heinrich J. Völk, Sabrina Casanova, Catalina Espinoza, M. Renaud, D. Berge, G. Vasileiadis, F. Salesa Greus, I. Jung-Richardt, Kleopas Shiningayamwe, Gilles Fontaine, J. T. Linnemann, Lenka Tomankova, M. Mostafá, G. Fichet de Clairfontaine, R. Konno, Gianluca Giavitto, V. Joshi, B. Peyaud, G. Pühlhofer, J. A. Goodman, H. Odaka, A. Reimer, R. W. Ellsworth, R. W. Springer, M. Curyło, F. Hueyotl-Zahuantitla, E. G. Pérez-Pérez, Y. Pérez Araujo, A. Nayerhoda, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, David Kieda, L. Mohrmann, Misao Sasaki, Markus Holler, Felix Jankowsky, Felix Aharonian, D. Glawion, Jesús Martínez-Castro, Segev BenZvi, Constantin Steppa, L. Giunti, D. A. Prokhorov, Ullrich Schwanke, L. Rinchiuso, J. A. Matthews, Ibrahim Torres, Rachel Simoni, A. Carosi, K. Egberts, S. Chandra, Ruben Alfaro, Sabrina Einecke, Iryna Lypova, Daniel Rosa-Gonzalez, Yvonne Becherini, M. Fernández Alonso, L. Dirson, G. Martí-Devesa, C. Trichard, Sylvia Zhu, P. J. Meintjes, J. H. E. Thiersen, Marion Spir-Jacob, Maria Haupt, C. D. Rho, Rafal Moderski, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Collaboration, H.E.S.S., and Collaboration, HAWC

Subjects
High-energy astronomy, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, IACT, Field of view, 030226 pharmacology & pharmacy, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Observatory, 0103 physical sciences, High Energy Stereoscopic System, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cherenkov radiation, media_common, Physics, [PHYS]Physics [physics], Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astronomy and Astrophysics, Galactic plane, Space and Planetary Science, Sky, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], High energy astrophysics
Abstract

International audience; The High Altitude Water Cherenkov (HAWC) observatory and the High Energy Stereoscopic System (H.E.S.S.) are two leading instruments in the ground-based very-high-energy γ-ray domain. HAWC employs the water Cherenkov detection (WCD) technique, while H.E.S.S. is an array of Imaging Atmospheric Cherenkov Telescopes (IACTs). The two facilities therefore differ in multiple aspects, including their observation strategy, the size of their field of view, and their angular resolution, leading to different analysis approaches. Until now, it has been unclear if the results of observations by both types of instruments are consistent: several of the recently discovered HAWC sources have been followed up by IACTs, resulting in a confirmed detection only in a minority of cases. With this paper, we go further and try to resolve the tensions between previous results by performing a new analysis of the H.E.S.S. Galactic plane survey data, applying an analysis technique comparable between H.E.S.S. and HAWC. Events above 1 TeV are selected for both data sets, the point-spread function of H.E.S.S. is broadened to approach that of HAWC, and a similar background estimation method is used. This is the first detailed comparison of the Galactic plane observed by both instruments. H.E.S.S. can confirm the γ-ray emission of four HAWC sources among seven previously undetected by IACTs, while the three others have measured fluxes below the sensitivity of the H.E.S.S. data set. Remaining differences in the overall γ-ray flux can be explained by the systematic uncertainties. Therefore, we confirm a consistent view of the γ-ray sky between WCD and IACT techniques.

Published
2021
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29. Is PKS 0625-354 another variable TeV active galactic nucleus?

Author

Halim Ashkar, Fabian Leuschner, Gilles Maurin, Riaan Steenkamp, J. F. Glicenstein, Heike Prokoph, Bruno Khelifi, Floriane Cangemi, Michael Punch, Gianluca Giavitto, Anna Luashvili, Lott Frans, Sumari Hattingh, Martin Tluczykont, Marek Jamrozy, Sabrina Einecke, Takaaki Tanaka, Iryna Lypova, Marion Spir-Jacob, Yvonne Becherini, Helene Sol, Rachel Simoni, Davit Zargaryan, Hannah Dalgleish, Jim Hinton, Gašper Kukec Mezek, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Andreas Zmija, Amid Nayerhoda, M. Lemoine-Goumard, Stefan Klepser, Alessandro Montanari, C. Arcaro, S. J. Fegan, Anu Kundu, B. Rudak, T. Chand, Hend Yassin, Michael Kreter, Paolo Marchegiani, Tadayuki Takahashi, Dmitriy Kostunin, Mathieu Bony, Oguzhan Anguener, Fabian Schüssler, Manuel Meyer, Markus Boettcher, Gavin Rowell, Kathrin Egberts, Maria Haupt, Victor Doroshenko, Emmanuel Moulin, Ira Jung, Brian van Soelen, Sebastian Panny, Mathieu Naurois, E. Kasai, Kirsty Feijen, Samuel Timothy Spencer, Dieter Horns, Vikas Joshi, Thomas Tavernier, Johannes Schaefer, Gerd Puehlhofer, Lei Sun, Constantin Steppa, Jacek Niemiec, Hassan Abdalla, Albert Seyffert, Olaf Reimer, Christian Stegmann, Stefan Wagner, Andreas Zech, Alexandre Marcowith, Regis Terrier, Felix Werner, Yasunobu Uchiyama, K. Nakashima, K. Bernloehr, Carlo Romoli, Hector Rueda Ricarte, Lukasz Stawarz, Frank M. Rieger, Thomas Murach, Kleopas Shiningayamwe, Clemens Hoischen, A. A. Zdziarski, Christopher van Eldik, N. Zywucka, Jaqueline Catalano, L. Mohrmann, Monica Barnard, Rafal Moderski, Heinrich J. Völk, Arnaud Mares, Ullrich Schwanke, Stefan Ohm, Thomas Bylund, Rowan Batzofin, Anita Reimer, Andreas Quirrenbach, Edna Ruiz Velasco, Johann van der Walt, Jhilik Majumdar, Guillem Marti'i-Devesa, R. Konno, Jacques Muller, Dan Parsons, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Lenka Tomankova, Stefano Gabici, Andrew Taylor, Michael Zacharias, Christo Venter, Sylvia Zhu, P. J. Meintjes, David Berge, M. Hörbe, Michael Backes, Robert Brose, V. Poireau, Jimmy N.S. Shapopi, V. Sahakian, Krzysztof Katarzynski, Brian Reville, Connor Duffy, Laenita Lorraine Oberholzer, Tim Holch, Anton Dmytriiev, M. Fuessling, Manami Sasaki, G. Vasileiadis, Catherine Boisson, Arache Djannati-Ataï, P. Reichherzer, J. Bolmont, Jason John Watson, D. Malyshev, Andrea Santangelo, Naomi Tsuji, Matthieu Renaud, Denys Malyshev, Isak Delberth Davids, G. Lamanna, James Davies, A. Fiasson, Roberta Zanin, Yves Gallant, S. Steinmassl, Sami Caroff, R. J. Tuffs, Gerard Fontaine, B. Bi, Santiago Pita, Hambeleleni Ndiyavala, Hester Schutte, Justine Devin, Mohanraj Senniappan, C. Levy, Mischa Breuhaus, Pauline Chambery, Andreas Specovius, Jean-Pierre Ernenwein, Yu Wun Wong, Johannes Veh, Vincent Marandon, Hannes Thiersen, Vardan Baghmanyan, Markus Holler, Q. Remy, Felix Jankowsky, Richard White, Felix Aharonian, Jacco Vink, Alison Mitchell, David Huber, Sabrina Casanova, Louis Du Plessis, Angel Noel, Jonathan Mackey, Anna Barnacka, C. Moore, Victor Barbosa Martins, Dorit Glawion, Carlo van Rensburg, Anne Lemiere, Tomasz Bulik, Malgorzata Curlo, Emma Ona-Wilhelmi, Samuel Zouari, Thomas Lohse, Lente Dreyer, Michal Ostrowski, J.-P. Lenain, Hugh Spackman, Stefan Funk, Alicja Wierzcholska, Ramin Marx, M. Panter, U. Katz, Faical Ait-Benkhali, G. Peron, Garret Cotter, Sébastien Le Stum, Zhiqiu Huang, D. A. Prokhorov, K. Kosack, P. T. O'Brien, Atreyee Sinha, Laura Olivera-Nieto, A. Yusafzai, Nukri Komin, Tom Armstrong, David Sanchez, Werner Hofmann, L. Giunti, Michelle Tsirou, Francois Brun, P. Vincent, Heiko Salzmann, Celine Armand, M.-H. Grondin, German Hermann, and Paul Morris

Subjects
Physics, Brightness, Active galactic nucleus, Astrophysics::High Energy Astrophysical Phenomena, Flux, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Viewing angle, Variable (computer science), symbols.namesake, symbols, Spectral energy distribution, Blazar, Doppler effect, Astrophysics::Galaxy Astrophysics
Abstract

The majority of the active galactic nuclei (AGN) detected at very-high-energies above 100 GeV belong to the class of blazars with a small angle between the jet-axis and the line-of-sight. Only about 10 percent of the gamma-ray AGN are objects with a larger viewing angle resulting in a smaller Doppler boosting of the emission. Originally, it was believed that gamma-ray emission can only be observed from blazars and those are variable in its brightness. Instead, the last years have shown that non-blazar active galaxies also show a fascinating variability behaviour which provide important new insights into the physical processes responsible for the gamma-ray production and especially for flaring events. Here, we report on the observation of gamma-ray variability of the active galaxy PKS 0625−354 detected with the H.E.S.S. telescopes in November 2018. The classification of PKS 0625−354 is a still matter of debate. The H.E.S.S. measurements were performed as part of a flux observing program and showed in the first night of the observation a detection of the object with > 5σ. A denser observation campaign followed for the next nine nights resulting in a decrease of the gamma-ray flux. Those observations were accompanied with Swift in the X-ray and UV/optical band allowing for the reconstruction of a multi-band broad-band spectral energy distribution. We will discuss the implications of the gamma-ray variability of the object.

Published
2021
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30. Search for dark matter annihilation towards the inner Milky Way halo with the H.E.S.S. Inner Galaxy Survey

Author

Clemens Hoischen, A. A. Zdziarski, Robert Brose, Johann van der Walt, Halim Ashkar, Fabian Leuschner, Stefan Ohm, L. Giunti, Albert Seyffert, Davit Zargaryan, Stefan Klepser, Alessandro Montanari, K. Nakashima, Gaëtan Fichet de Clairfontaine, Sabrina Einecke, Axel Donath, A. W. Chen, Iryna Lypova, K. Bernloehr, Heinrich J. Völk, Yvonne Becherini, Stefano Gabici, Michelle Tsirou, Anna Luashvili, Vikas Joshi, J. Bolmont, Fabian Schüssler, M.-H. Grondin, Emmanuel Moulin, Andreas Specovius, Kleopas Shiningayamwe, Anne Lemiere, B. Rudak, Lott Frans, Michael Punch, Edna Ruiz Velasco, Sylvia Zhu, P. J. Meintjes, David Berge, Michael Backes, Matthieu Renaud, German Hermann, Paul Morris, Kathrin Egberts, Constantin Steppa, Tadayuki Takahashi, Laenita Lorraine Oberholzer, Tim Holch, Lukasz Stawarz, Louis Du Plessis, Naomi Tsuji, V. Poireau, Jimmy N.S. Shapopi, Victor Doroshenko, Yu Wun Wong, Emma Ona-Wilhelmi, Riaan Steenkamp, E. Kasai, G. Lamanna, Ullrich Schwanke, Gerard Fontaine, Jim Hinton, Victor Barbosa Martins, Thomas Lohse, Frank M. Rieger, Hester Schutte, Carlo van Rensburg, Francois Brun, P. Vincent, Heiko Salzmann, Mathieu Bony, Oguzhan Anguener, Kirsty Feijen, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Ramin Marx, Dmitriy Kostunin, M. Panter, U. Katz, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Jaqueline Catalano, R. Konno, Hector Rueda Ricarte, T. Chand, Samuel Zouari, P. T. O'Brien, M. Hörbe, Celine Armand, Andreas Quirrenbach, Guillem Marti'i-Devesa, Faical Ait-Benkhali, Andrew Taylor, G. Vasileiadis, Vincent Marandon, Brian van Soelen, Marek Jamrozy, Hannes Thiersen, Dieter Horns, Hassan Abdalla, Thomas Bylund, Rowan Batzofin, Sébastien Le Stum, Thomas Tavernier, Gilles Maurin, Floriane Cangemi, Helene Sol, Christian Stegmann, Jacques Muller, Vardan Baghmanyan, Johannes Schaefer, J. F. Glicenstein, Anu Kundu, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, Monica Barnard, L. Mohrmann, Arache Djannati-Ataï, C. Levy, Atreyee Sinha, Bruno Khelifi, Michal Ostrowski, J.-P. Lenain, Hugh Spackman, Michael Zacharias, Regis Terrier, Hannah Dalgleish, P. Reichherzer, Andreas Zmija, Gianluca Giavitto, Jacek Niemiec, M. Lemoine-Goumard, Paolo Marchegiani, Markus Holler, Carlo Romoli, Isak Delberth Davids, Stefan Funk, Alicja Wierzcholska, Olaf Reimer, Q. Remy, Felix Jankowsky, Michael Kreter, Anna Barnacka, Brian Reville, Connor Duffy, A. Fiasson, Roberta Zanin, Thomas Murach, Heike Prokoph, James Davies, Sumari Hattingh, Felix Aharonian, Richard White, Angel Noel, M. Fuessling, R. J. Tuffs, B. Bi, Christo Venter, Takaaki Tanaka, D. Malyshev, Jonathan Mackey, Jacco Vink, Ira Jung, Sebastian Panny, Alison Mitchell, Anita Reimer, David Huber, Sabrina Casanova, Marion Spir-Jacob, Mischa Breuhaus, Pauline Chambery, Gerd Puehlhofer, C. Arcaro, C. Moore, Jhilik Majumdar, Lei Sun, Santiago Pita, Hambeleleni Ndiyavala, S. Steinmassl, Sami Caroff, Anton Dmytriiev, Dorit Glawion, G. Peron, Garret Cotter, Alexandre Marcowith, Felix Werner, Amid Nayerhoda, Manami Sasaki, Tomasz Bulik, Zhiqiu Huang, Malgorzata Curlo, Maria Haupt, Andrea Santangelo, Arnaud Mares, Lente Dreyer, D. A. Prokhorov, K. Kosack, V. Sahakian, Gavin Rowell, Jean-Pierre Ernenwein, N. Zywucka, Denys Malyshev, Markus Boettcher, Yves Gallant, Christopher van Eldik, Rafal Moderski, Johannes Veh, Samuel Timothy Spencer, Mohanraj Senniappan, Rachel Simoni, Dan Parsons, Krzysztof Katarzynski, Catherine Boisson, Justine Devin, Lenka Tomankova, Martin Tluczykont, Gašper Kukec Mezek, Hend Yassin, Manuel Meyer, Mathieu Naurois, Jason John Watson, S. J. Fegan, Nukri Komin, Tom Armstrong, David Sanchez, Werner Hofmann, Laura Olivera-Nieto, and A. Yusafzai

Subjects
Physics, Annihilation, WIMP, Milky Way, Weakly interacting massive particles, media_common.quotation_subject, Dark matter, Astrophysics::Cosmology and Extragalactic Astrophysics, Halo, Astrophysics, Galaxy, Universe, media_common
Abstract

The presence of dark matter (DM) is suggested by a wealth of astrophysical and cosmological measurements. However, its underlying nature is yet unknown. Among the most promising candidates are weakly interacting massive particles (WIMPs): particles with mass and coupling strength at the electroweak scale and thermally produced in the early universe have a present relic density consistent with that observed today. WIMP self-annihilation would produce Standard Model particles including gamma-rays, which have been long-time recognized as a prime messenger to indirectly detect dark matter signals. The centre of the Milky Way is predicted as the brightest source of DM annihilations. The H.E.S.S. collaboration is currently performing a survey of the inner region of the Milky Way, the Inner Galaxy Survey (IGS), intended to achieve the best sensitivity to faint and diffuse emissions in a region of several degrees around the Galactic Centre. We analyzed 2014-2020 observations taken with the five-telescope array to search for a DM annihilation signal. With the current dataset of about 550 hours, we found no significant excess and therefore derived strong constraints on the velocity-weighted annihilation cross-section. TeV thermal WIMPs can be probed in different annihilation channels.

Published
2021
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34. The young massive stellar cluster Westerlund 1 in gamma rays as seen with H.E.S.S

Author

Lars Mohrmann, Hassan Abdalla, Felix Aharonian, Faical Ait-Benkhali, Oguzhan Anguener, Cornelia Arcaro, Celine Armand, Tom Armstrong, Halim Ashkar, Michael Backes, Vardan Baghmanyan, Victor Barbosa Martins, Anna Barnacka, Monica Barnard, Rowan William Batzofin, Yvonne Becherini, David Berge, Konrad Bernloehr, Baiyang Bi, Markus Böttcher, Catherine Boisson, Julien Bolmont, Mathieu Bony (de), Mischa Breuhaus, Robert Brose, Francois Brun, Tomasz Bulik, Thomas Bylund, Floriane Cangemi, Sami Caroff, Sabrina Casanova, Jaqueline Catalano, Pauline Chambery, Tej Bahadur Chand, Andrew Chen, Garret Cotter, Malgorzata Curlo, Hannah Dalgleish, Jean Damascene Mbarubucyeye, Isak Delberth Davids, James Davies, Justine Devin, Arache Djannati-Ataï, Anton Dmytriev, Axel Donath, Victor Doroshenko, Lente Dreyer, Louis Du Plessis, Connor Duffy, Kathrin Egberts, Sabrina Einecke, Jean-Pierre ERNENWEIN, Steven Fegan, Kirsty Feijen, Armand Fiasson, Gaëtan Fichet de Clairfontaine, Gerard Fontaine, Lott Frans, Matthias Fuessling, Stefan Funk, Stefano Gabici, Yves Gallant, Gianluca Giavitto, Luca Giunti, Dorit Glawion, Jean-Francois Glicenstein, Marie-Hélène Grondin, Sumari Hattingh, Maria Haupt, German HERMANN, Jim Hinton, Werner Hofmann, Clemens Hoischen, Tim Holch, Markus Holler, Dieter Horns, Zhi-Qiu Huang, David Huber, Mario Hörbe, Marek Jamrozy, Felix Jankowsky, Vikas Joshi, Ira JUNG, Eli Kasai, Krzysztof Katarzynski, Ulì Katz, Dmitry Khangulyan, Bruno Khelifi, Stefan Klepser, Wlodek Kluzniak, Nukri Komin, Ruslan Konno, Karl Kosack, Dmitriy Kostunin, Michael Kreter, Gašper Kukec Mezek, Anu Kundu, Giovanni Lamanna, Sebastien Le Stum, Anne Lemiere, Marianne Lemoine-Goumard, Jean-Philippe Lenain, Fabian Leuschner, Christelle Levy, Thomas Lohse, Anna Luashvili, Iryna Lypova, Jonathan Mackey, Jhilik Majumdar, Denys Malyshev, Dmitry Malyshev, Vincent Marandon, Paolo Marchegiani, Alexandre Marcowith, Arnaud Mares, Guillem Martí-Devesa, Ramin Marx, Gilles Maurin, Pieter Meintjes, Manuel Meyer, Alison Mitchell, Rafal Moderski, Alessandro Montanari, Chris Moore, Paul Morris, Emmanuel Moulin, Jacques Muller, Thomas Murach, Kaori Nakashima, Mathieu Naurois (de), Amid Nayerhoda, Hambeleleni Davids, Jacek Niemiec, Angel Noel, Paul O'Brien, Laenita Lorraine Oberholzer, Stefan Ohm, Laura Olivera-Nieto, Emma Ona-Wilhelmi (de), Michal Ostrowski, Sebastian Panny, Michael Panter, Dan Parsons, Giada Peron, Santiago Pita, Vincent Poireau, Dmitry A Prokhorov, Heike Prokoph, Gerd PUEHLHOFER, Michael Punch, Andreas Quirrenbach, Romed Rauth, Patrick Reichherzer, Anita Reimer, Olaf Reimer, Quentin Remy, Matthieu Renaud, Brian Reville, Frank Rieger, Carlo Romoli, Gavin P Rowell, Bronislaw Rudak, Hector Rueda Ricarte, Edna Ruiz Velasco, Vardan Sahakian, Simon Sailer, Heiko Salzmann, David Sanchez, Andrea Santangelo, Manami Sasaki, Johannes Schaefer, Hester Schutte, Ullrich Schwanke, Fabian Schüssler, Mohanraj Senniappan, Albert Seyffert, Jimmy N.S. Shapopi, Kleopas Shiningayamwe, Rachel Simoni, Atreyee Sinha, Helene Sol, Hugh Spackman, Andreas Specovius, Samuel Timothy Spencer, Marion Spir-Jacob, Lukasz Stawarz, Riaan Steenkamp, Christian Stegmann, Simon Steinmassl, Constantin Steppa, Lei Sun, Tadayuki Takahashi, Takaaki Tanaka, Thomas Tavernier, Andrew Taylor, Regis Terrier, Hannes Thiersen, Charles Thorpe-Morgan, Martin Tluczykont, Lenka Tomankova, Michelle Tsirou, Naomi Tsuji, Richard Tuffs, Yasunobu Uchiyama, Johann van der Walt, Christopher van Eldik, Carlo van Rensburg, Brian van Soelen, George Vasileiadis, Johannes Veh, Christo Venter, Pascal Vincent, Jacco Vink, Heinrich J. Völk, Stefan Wagner, Jason John Watson, Felix Werner, Richard White, Alicja Wierzcholska, Yu Wun Wong, Hend Mahmoud Yassin, Anke Yusafzai, Michael Zacharias, Roberta Zanin, Davit Zargaryan, Andrzej Zdziarski, Andreas Zech, Sylvia Zhu, Andreas Zmija, Samuel Zouari, Natalia Żywucka, Naurois , Mathieu, Ona-Wilhelmi , Emma, and Bony , Mathieu

Subjects
Physics, Milky Way, Astrophysics::High Energy Astrophysical Phenomena, Hadron, Gamma ray, Cosmic ray, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Likelihood analysis, Energy spectrum, Cluster (physics), ddc:530, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics
Abstract

37th International Cosmic Ray Conference, ICRC 2021, Berlin, online, Germany, 12 Jul 2021 - 23 Jul 2021; Proceedings of Science / International School for Advanced Studies (ICRC2021), 789 (2021). doi:10.22323/1.395.0789, Massive stellar clusters have recently been hypothesised as candidates for the acceleration of hadronic cosmic rays up to PeV energies. Previously, the H.E.S.S. Collaboration has reported about very extended $\gamma$-ray emission around Westerlund 1, a massive young stellar cluster in the Milky Way. In this contribution we present an updated analysis that employs a new analysis technique and is based on a much larger data set, allowing us to constrain better the morphology and the energy spectrum of the emission. The analysis technique used is a three-dimensional likelihood analysis, which is especially well suited for largely extended sources. The origin of the $\gamma$-ray emission will be discussed in light of multi-wavelength observations., Published by SISSA, Trieste

Published
2021
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35. Revealing x-ray and gamma ray temporal and spectral similarities in the GRB 190829A afterglow

Author

K. Egberts, Davit Zargaryan, Axel Donath, A. W. Chen, G. Pühlhofer, M. de Bony de Lavergne, V. Poireau, P. T. O'Brien, P. A. Evans, Riaan Steenkamp, A. Lemiere, F. Eichhorn, Nu. Komin, J. Schäfer, Włodek Kluźniak, A. S. Seyffert, N. Shafi, Natalia Żywucka, Sebastian Panny, R. J. White, Domenico Tiziani, D. Malyshev, T. Chand, Jhilik Majumdar, V. Baghmanyan, Clemens Hoischen, A. A. Zdziarski, Jacco Vink, Alison Mitchell, Joachim Hahn, M. Füßling, C. van Eldik, J.F. Glicenstein, Lei Sun, P. Reichherzer, Jim Davies, A. Carosi, Zorawar Wadiasingh, Q. Remy, Anna Barnacka, A. Djannati-Ataï, A. Montanari, E. Moulin, M. de Naurois, Alexandre Marcowith, Arnaud Mares, Christoph Deil, Sabrina Casanova, Christo Venter, G. Peron, Garret Cotter, M. Hörbe, Dmitriy Kostunin, E. Ruiz-Velasco, Mohanraj Senniappan, Thomas Bylund, E. O. Angüner, S. Raab, Tadayuki Takahashi, F. Brun, R. J. Tuffs, B. Bi, H. Prokoph, C. van Rensburg, A. Zech, J. Muller, Monica Barnard, B. Peyaud, Kirsty Feijen, R. Rauth, Pierre Brun, Victor Doroshenko, Michael Punch, E. Kasai, Konrad Bernlöhr, M. Curyło, Stefano Gabici, Gianluca Giavitto, Frank M. Rieger, Michael Backes, Stefan Klepser, J.-P. Ernenwein, A. Dmytriiev, Mischa Breuhaus, J. Dyks, G. Emery, L. Olivera-Nieto, Tim Holch, S. Fegan, Samuel Zouari, M.-H. Grondin, L. Mohrmann, Stefan Ohm, I. Jung-Richardt, Markus Böttcher, K. Kosack, A. Reimer, G. Hermann, Marek Jamrozy, Regis Terrier, S. Pita, Markus Holler, Felix Jankowsky, Armelle Jardin-Blicq, E. de Ona Wilhelmi, A.M. Taylor, Carlo Romoli, J. Damascene Mbarubucyeye, Hester Schutte, Dieter Horns, Jonathan Mackey, Tom Armstrong, Helene Sol, Sylvia Zhu, P. J. Meintjes, Hambeleleni Ndiyavala, G. Fontaine, H. Odaka, Felix Aharonian, V. Barbosa Martins, Andreas Specovius, Michal Ostrowski, Johannes Veh, D. J. van der Walt, Yu Wun Wong, L. Oakes, C. Moore, J. Bolmont, D. Jankowsky, M. Seglar-Arroyo, Paolo Marchegiani, Rachel Simoni, R. Marx, S. Steinmassl, D. Glawion, Łukasz Stawarz, Manuel Meyer, Tomasz Bulik, Lente Dreyer, Andreas Quirrenbach, Sabrina Einecke, Iryna Lypova, Constantin Steppa, D. A. Prokhorov, M. Zacharias, Christopher J. Duffy, A. Wierzcholska, M. Tluczykont, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, F. Schüssler, Yvonne Becherini, Jimmy N.S. Shapopi, C. Levy, Werner Hofmann, G. Lamanna, M. A. Kastendieck, James E. M. Watson, Ullrich Schwanke, G. Vasileiadis, Isak Delberth Davids, Misao Sasaki, Bruno Khelifi, M. Büchele, M. Lemoine-Goumard, J. Zorn, Elisabetta Bissaldi, Roberta Zanin, F. Ait Benkhali, L. Rinchiuso, M. Scalici, Y. A. Gallant, J. Devin, Jim Hinton, D. Berge, V. Sahakian, F. Werner, Andrea Santangelo, Stefan Funk, S. Sailer, Dmitry Khangulyan, Michael Kreter, Jacek Niemiec, D. A. Sanchez, A. Priyana Noel, C. Arcaro, Fabian Leuschner, J. H. E. Thiersen, M. Panter, U. Katz, K. Nakashima, Olaf Reimer, G. Martí-Devesa, H. Ashkar, Q. Piel, P. Morris, Gavin Rowell, M. Bryan, Kleopas Shiningayamwe, A. Yusafzai, Thomas Murach, G. Maurin, Maria Haupt, Heinrich J. Völk, M. Renaud, R. D. Parsons, Samuel Timothy Spencer, Lenka Tomankova, T. Tam, G. Fichet de Clairfontaine, A. Sinha, J.-P. Lenain, D. Huber, Rafal Moderski, S. Caroff, B. van Soelen, S. Chandra, R. Konno, L. Dirson, M. Tsirou, B. Rudak, V. Joshi, Thomas Lohse, L. Giunti, A. Nayerhoda, Hassan Abdalla, A. Fiasson, M. Spir-Jacob, V. Marandon, K. Katarzyński, P. Vincent, T. Tavernier, K. L. Page, Heiko Salzmann, Celine Armand, Catherine Boisson, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), H.E.S.S., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), H.E.S.S. Collaboration, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)

Subjects
Photon, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, gamma ray: burst, 01 natural sciences, Luminosity, HESS, 0103 physical sciences, High Energy Stereoscopic System, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, energy: high, Multidisciplinary, X-ray: energy spectrum, 010308 nuclear & particles physics, photon, Gamma ray, trigger, Light curve, redshift, Redshift, Afterglow, collapse, gamma ray: VHE, HESS - Abteilung Hinton, spectral, Astrophysics - High Energy Astrophysical Phenomena, Gamma-ray burst, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], absorption
Abstract

An intrinsic gamma-ray burst afterglow Long gamma-ray bursts (GRBs) are emitted by relativistic jets generated during the collapse of a massive star in a distant galaxy. The GRB itself lasts only a few seconds but is followed by an afterglow that can persist for hours or days. The H.E.S.S. Collaboration observed the afterglow of GRB 190829A, a nearby long GRB. The proximity of this burst allowed it to be detected at tera–electron volt energies that would otherwise be absorbed in the intergalactic medium. By analyzing the spectrum and light curve at x-ray and gamma-ray wavelengths, the authors show that the afterglow cannot be explained by standard models. Science , abe8560, this issue p. 1081

Published
2021
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36. Deep observations of Kepler's SNR with H.E.S.S

Author

Jason John Watson, Kleopas Shiningayamwe, Edna Ruiz Velasco, Lenka Tomankova, Martin Tluczykont, Gašper Kukec Mezek, Hend Yassin, Manuel Meyer, Mathieu Naurois, Anton Dmytriiev, Manami Sasaki, Riaan Steenkamp, Andrea Santangelo, T. Chand, Gilles Maurin, J. F. Glicenstein, Jhilik Majumdar, Johannes Schaefer, Christian Stegmann, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, Bruno Khelifi, Anu Kundu, Hector Rueda Ricarte, Davit Zargaryan, Jacek Niemiec, L. Mohrmann, Arache Djannati-Ataï, Albert Seyffert, V. Sahakian, Anna Barnacka, P. Reichherzer, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Ira Jung, Olaf Reimer, G. Peron, Christo Venter, Garret Cotter, Sebastian Panny, K. Nakashima, K. Bernloehr, Isak Delberth Davids, Victor Barbosa Martins, A. Fiasson, Roberta Zanin, Yves Gallant, Fabian Schüssler, Michael Backes, Heinrich J. Völk, Gerd Puehlhofer, Lei Sun, Thomas Murach, Jean-Pierre Ernenwein, Emmanuel Moulin, G. Lamanna, V. Poireau, Jimmy N.S. Shapopi, Alexandre Marcowith, Felix Werner, Laenita Lorraine Oberholzer, Tim Holch, Naomi Tsuji, Carlo van Rensburg, Zhiqiu Huang, D. A. Prokhorov, K. Kosack, Tadayuki Takahashi, Markus Holler, Q. Remy, Felix Jankowsky, Victor Doroshenko, Felix Aharonian, Johannes Veh, Gerard Fontaine, E. Kasai, G. Vasileiadis, M.-H. Grondin, Anne Lemiere, Floriane Cangemi, Arnaud Mares, Samuel Zouari, Denys Malyshev, Alison Mitchell, Samuel Timothy Spencer, Hester Schutte, Stefan Klepser, Andreas Specovius, Alessandro Montanari, Andreas Zmija, Clemens Hoischen, A. A. Zdziarski, M. Lemoine-Goumard, Emma Ona-Wilhelmi, Yu Wun Wong, Stefan Ohm, Dan Parsons, Johann van der Walt, Vikas Joshi, Brian Reville, Connor Duffy, Michael Kreter, Gianluca Giavitto, D. Malyshev, Thomas Lohse, Mohanraj Senniappan, James Davies, Vincent Marandon, Hannes Thiersen, R. J. Tuffs, Hannah Dalgleish, Vardan Baghmanyan, P. T. O'Brien, Stefano Gabici, Thomas Bylund, Krzysztof Katarzynski, Michal Ostrowski, B. Bi, J.-P. Lenain, Catherine Boisson, Hugh Spackman, Michael Punch, Lukasz Stawarz, Sumari Hattingh, Monica Barnard, Jaqueline Catalano, Takaaki Tanaka, Rowan Batzofin, Mischa Breuhaus, Pauline Chambery, Stefan Funk, Alicja Wierzcholska, R. Konno, Ramin Marx, M. Panter, Anna Luashvili, Justine Devin, J. Bolmont, U. Katz, Francois Brun, Richard White, Jacques Muller, Andrew Taylor, P. Vincent, N. Zywucka, Andreas Quirrenbach, Laura Olivera-Nieto, A. Yusafzai, Dieter Horns, Guillem Marti'i-Devesa, Hassan Abdalla, Heiko Salzmann, Jacco Vink, Mathieu Bony, Oguzhan Anguener, Michael Zacharias, Celine Armand, Atreyee Sinha, Marek Jamrozy, Kirsty Feijen, Faical Ait-Benkhali, Lott Frans, Robert Brose, Santiago Pita, Hambeleleni Ndiyavala, L. Giunti, David Huber, German Hermann, Paul Morris, M. Hörbe, Helene Sol, Sabrina Casanova, Jim Hinton, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Sébastien Le Stum, Paolo Marchegiani, Michelle Tsirou, Constantin Steppa, Halim Ashkar, Fabian Leuschner, Ullrich Schwanke, C. Arcaro, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Gavin Rowell, Regis Terrier, B. Rudak, Carlo Romoli, Kathrin Egberts, Nukri Komin, Tom Armstrong, Frank M. Rieger, Matthieu Renaud, M. Fuessling, David Sanchez, Heike Prokoph, C. Levy, S. Steinmassl, Sami Caroff, Werner Hofmann, Marion Spir-Jacob, S. J. Fegan, Amid Nayerhoda, Sylvia Zhu, P. J. Meintjes, David Berge, Maria Haupt, Christopher van Eldik, Rafal Moderski, Dmitriy Kostunin, Brian van Soelen, Thomas Tavernier, Markus Boettcher, Sabrina Einecke, Iryna Lypova, Anita Reimer, Yvonne Becherini, Rachel Simoni, Angel Noel, Jonathan Mackey, C. Moore, Dorit Glawion, Tomasz Bulik, Malgorzata Curlo, Lente Dreyer, Louis Du Plessis, Naurois , Mathieu, Ona-Wilhelmi , Emma, and Bony , Mathieu

Subjects
Astrophysics::High Energy Astrophysical Phenomena, atmosphere [Cherenkov counter], VHE [gamma ray], IACT, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Cherenkov counter: atmosphere, Kepler, HESS, supernova, Astrophysics::Solar and Stellar Astrophysics, ddc:530, High Energy Stereoscopic System, cosmic radiation: acceleration, Supernova remnant, Cherenkov radiation, Astrophysics::Galaxy Astrophysics, Physics, energy: high, Astrophysics::Instrumentation and Methods for Astrophysics, imaging, Galaxy, Cassiopeia A, Supernova, gamma ray: VHE, high [energy], acceleration [cosmic radiation], galaxy
Abstract

37th International Cosmic Ray Conference, ICRC 2021, Berlin, online, Germany, 12 Jul 2021 - 23 Jul 2021; Proceedings of Science / International School for Advanced Studies (ICRC2021), 805 (2021). doi:10.22323/1.395.0805, Kepler���s supernova remnant (SNR) which is produced by the most recent naked-eye supernova in our Galaxy is one of the best studied SNRs, but its gamma-ray detection has eluded us so far. Observations with modern imaging atmospheric Cherenkov telescopes (IACT) have enlarged the knowledge about nearby SNRs with ages younger than 500 years by establishing Cassiopeia A and Tycho���s SNRs as very high energy (VHE) gamma-ray sources and setting a lower limit on the distance to Kepler���s SNR. This SNR is significantly more distant than the other two and expected to be one of the faintest gamma-ray sources within reach of the IACT arrays of this generation. We report strong evidence for a VHE signal from Kepler���s SNR based on deep observations of the High Energy Stereoscopic System (H.E.S.S.) with an exposure of 152 hours, including 122 hours accumulated in 2017-2020. We further discuss implications of this result for cosmic-ray acceleration in young SNRs., Published by SISSA, Trieste

Published
2021
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37. H.e.s.s. And magic observations of a sudden cessation of a very-high-energy γ -ray flare in PKS 1510-089 in May 2016

Author

A. Yusafzai, J. van Scherpenberg, M. Büchele, B. Boccardi, S. Caroff, S. J. Fegan, Daniela Dorner, T. Schweizer, Mosè Mariotti, Gaia Vanzo, Tom Armstrong, Nu. Komin, Pratik Majumdar, M. V. Fonseca, Matteo Cerruti, A. Lemiere, F. Eichhorn, J. Devin, C. Trichard, Michael Punch, Stefano Gabici, M. Palatiello, V. A. Acciari, F. Schüssler, Sylvia Zhu, P. J. Meintjes, Werner Hofmann, Samuel Timothy Spencer, Y. Kajiwara, J. Zorn, D. Dominis Prester, S. Bonnefoy, Constantin Steppa, G. Maurin, Adrian Biland, J. M. Paredes, Antonio Stamerra, U. Barres de Almeida, Tadayuki Takahashi, Damir Lelas, Victor Doroshenko, Davide Depaoli, Dmitriy Kostunin, R. Mirzoyan, T. Surić, D. Gottschall, M. Füßling, Moritz Hütten, Lea Heckmann, M. Gaug, J. Herrera, Ullrich Schwanke, C. Arcaro, H. Abdalla, Lorenzo Bellizzi, Thomas P. Krichbaum, Francesco Dazzi, John Hoang, Martin Will, Dominik Baack, L. Maraschi, Elina Lindfors, M. A. Kastendieck, R. Rauth, V. Baghmanyan, D. Ninci, Koji Noda, Michael Backes, S. Raab, Sanae Inoue, Giacomo D'Amico, Manuel Meyer, Q. Remy, L. Olivera-Nieto, Dorota Sobczyńska, Elisa Bernardini, M. Filipovic, Riaan Steenkamp, Davit Zargaryan, Hambeleleni Ndiyavala, Stefan Klepser, G. Vasileiadis, G. Lamanna, S. G. Jorstad, Daniel Mazin, Jacek Niemiec, Kirsty Feijen, Alessandro Montanari, Tim Holch, Seiya Nozaki, Anna Barnacka, M. Hörbe, Giacomo Bonnoli, D. Strom, T. Tavernier, Takeshi Oka, Axel Donath, J. Rico, A. W. Chen, J. Dyks, T. Chand, Jim Hinton, F. Niederwanger, Olaf Reimer, Daniel Kerszberg, Manuel Delfino, Krzysztof Katarzynski, Ivica Puljak, S. Sailer, Dmitry Khangulyan, Christian Fruck, Gavin Rowell, D. A. Sanchez, Maria Haupt, Julian Sitarek, Alan P. Marscher, Stefano Truzzi, Pablo Peñil, E. O. Angüner, Catherine Boisson, S. Ventura, Dieter Horns, M. Bryan, V. Barbosa Martins, L. Sun, Rachel Simoni, Gerard Fontaine, Jacco Vink, P. Reichherzer, Jim Davies, G. Hermann, Regis Terrier, Clemens Hoischen, A. A. Zdziarski, G. Ferrara, Francois Brun, G. Emery, M. de Bony de Lavergne, P. Vincent, Kyoshi Nishijima, Alessandra Lamastra, G. Fichet de Clairfontaine, E. de Oña Wilhelmi, P. Munar-Adrover, Yoshiki Ohtani, Carlo Romoli, Jordi Delgado, Wrijupan Bhattacharyya, L. Di Venere, D. Zarić, Zorawar Wadiasingh, F. Di Pierro, Ž. Bošnjak, Hester Schutte, Isak Delberth Davids, Roberta Zanin, Karl Mannheim, M. Strzys, Łukasz Stawarz, R. J. Tuffs, V. Fallah Ramazani, B. Bi, Marc Ribó, Sabrina Casanova, H. Prokoph, A. Carosi, Stefano Covino, D. J. van der Walt, Thomas Murach, Yating Chai, Saša Mićanović, Jae-Young Kim, V. Vitale, Francesco Longo, R. Konno, Alicia Fattorini, Narek Sahakyan, Y. A. Gallant, R. J. García López, Junko Kushida, Jürgen Besenrieder, Dario Hrupec, P. Da Vela, S. Steinmassl, P. G. Prada Moroni, Jonathan Mackey, Rafal Moderski, Stefan Cikota, Hidetoshi Kubo, Armelle Jardin-Blicq, Monica Barnard, J. Otero-Santos, Mischa Breuhaus, J. Becerra González, Yu. W. Wong, V. Joshi, Samuel Zouari, N. Shafi, Natalia Żywucka, E. Prandini, M. A. Lopez, Gianluca Giavitto, Katsuaki Asano, Mitsunari Takahashi, T. Vuillaume, M. Curyło, P. Morris, K. Egberts, Stefano Ansoldi, M. de Naurois, Pawel Gliwny, L. Pavletić, C. Moore, Alessia Spolon, M. Vazquez Acosta, D. Elsaesser, Tomoki Saito, Giovanni Ceribella, Riccardo Paoletti, Celine Armand, Jhilik Majumdar, Stefan Ohm, G. Busetto, Léa Jouvin, Ana Babić, Frank M. Rieger, A. Dmytriiev, Dorit Glawion, Z. R. Weaver, Włodek Kluźniak, S. Chandra, V. Marandon, A. Djannati-Ataï, E. Moulin, Tomasz Bulik, Alessio Berti, M. Seglar-Arroyo, H. Odaka, Christian Stegmann, Stefan Wagner, C. Perennes, Pierre Brun, Yasunobu Uchiyama, A. Fiasson, U. Colin, David A. Green, Kazuma Ishio, A. Arbet Engels, A. De Angelis, Wlodek Bednarek, Nikola Godinovic, F. Ait Benkhali, Vassil Verguilov, Camilla Maggio, L. Mohrmann, Jean-Pierre Ernenwein, M. Spir-Jacob, M. Karjalainen, Vitaly Neustroev, P. deWilt, M. Scalici, Victoria Moreno, A. Priyana Noel, A. López-Oramas, M. Lemoine-Goumard, N. Torres-Albà, Martin Makariev, C. van Rensburg, Oscar Blanch, S. Pita, Alexander Hahn, V. Sahakian, Yusuke Suda, S. Schwemmer, Thomas Lohse, Misao Sasaki, Daniel Morcuende, Johannes Veh, D. Jankowsky, Michael Kreter, D. Berge, Luca Tosti, R. Marx, F. Werner, V. Poireau, Andrea Santangelo, C. Nigro, Andreas Quirrenbach, Jose Luis Contreras, E. Ruiz-Velasco, Thomas Bylund, M. Tluczykont, V. D'Elia, A. S. Seyffert, Jose Miguel Miranda, Massimo Persic, L. Dirson, Efthalia Traianou, Carlo Vigorito, Sargis Gasparyan, Y. Kobayashi, Jacques Muller, Jeffrey A. Hodgson, Marek Jamrozy, Christoph Deil, I. Jung-Richardt, Joachim Hahn, Mohanraj Senniappan, A. Rugliancich, Marina Manganaro, K. Nakashima, Kleopas Shiningayamwe, Alice Donini, Michelle Tsirou, Yuki Iwamura, G. Maneva, L. A. Antonelli, Juan Cortina, Markus Holler, Michal Ostrowski, Wolfgang Rhode, L. Rinchiuso, Felix Jankowsky, Sebastian Panny, M. I. Martínez, Michael Zacharias, Ferdinando Giordano, Felix Aharonian, Lluis Font, J.-P. Lenain, Merja Tornikoski, B. Machado de Oliveira Fraga, M.-H. Grondin, Lenka Tomankova, Markus Böttcher, Alison Mitchell, Chiara Righi, E. Do Souto Espiñeira, Tomislav Terzić, Alexandre Marcowith, P. Temnikov, Helene Sol, Sabrina Einecke, Iryna Lypova, Toshiaki Inada, Rodolfo Carosi, R. D. Parsons, Yvonne Becherini, Shunsuke Sakurai, L. Giunti, A. Nayerhoda, Arnaud Mares, Chaitanya Priyadarshi, Satoshi Fukami, Konstancja Satalecka, Stefan Funk, Johan Bregeon, Sidika Merve Colak, Alicja Wierzcholska, R. J. White, F. Leone, Michele Doro, D. Huber, Carolina Casadio, Anne Lähteenmäki, Masahiro Teshima, Domenico Tiziani, D. Malyshev, M. Panter, U. Katz, Heinrich J. Völk, G. Martí-Devesa, C. Levy, M. Renaud, J. A. Barrio, Kai Phillip Schmidt, L. Oakes, N. Giglietto, Simone Mender, Paolo Marchegiani, Ashot Chilingarian, Tjark Miener, James E. M. Watson, David Paneque, J. Bolmont, Manuela Mallamaci, Halim Ashkar, A. Sinha, Fabrizio Tavecchio, Kari Nilsson, B. van Soelen, B. Rudak, R. Adam, D. Miceli, M. Mohamed, Saverio Lombardi, E. Molina, P. T. O'Brien, E. Colombo, Lab Saha, Luca Foffano, C. van Eldik, G. Peron, Garret Cotter, D. Hadasch, D. A. Prokhorov, K. Kosack, Konrad Bernlöhr, B. Peyaud, I. Vovk, G. Pühlhofer, A. Reimer, J. F. Glicenstein, Bruno Khelifi, Serena Loporchio, I. Snidaric, Abelardo Moralejo, Andreas Specovius, E. Moretti, Bernd Schleicher, M. Minev, B. De Lotto, Andrés Baquero, A.M. Taylor, J. Damascene Mbarubucyeye, Christo Venter, Ciro Bigongiari, A. Zech, M. Garczarczyk, R. López-Coto, Q. Piel, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), H.E.S.S., MAGIC, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), German Research Foundation, Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Department of Atomic Energy (India), Academy of Finland, University of Tokyo, La Caixa, Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, Abdalla, H., Adam, R., Aharonian, F., Ait Benkhali, F., Ang??ner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernl??hr, K., Bi, B., B??ttcher, M., Boisson, C., Bolmont, J., Bonnefoy, S., de Bony de Lavergne, M., Bregeon, J., Breuhaus, M., Brun, F., Brun, P., Bryan, M., B??chele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chandra, S., Chen, A., Cotter, G., Cury??o, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Ata??, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., Fichet de Clairfontaine, G., Filipovic, M., Fontaine, G., Funk, S., F????ling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., H??rbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kastendieck, M. A., Katarzy??ski, K., Katz, U., Khangulyan, D., Kh??lifi, B., Klepser, S., Klu??niak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemi??re, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Mart??-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A. M. W., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O???brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., de Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Priyana Noel, A., Prokhorov, D. A., Prokoph, H., P??hlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Sch??ssler, F., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, ??., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., V??lk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Yu. W., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zorn, J., Zouari, S., ywucka, N., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Asano, K., Baack, D., Babi??, A., Baquero, A., Barres de Almeida, U., Barrio, J. A., Becerra Gonz??lez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bo??njak, ??., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D???amico, G., D???elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espi??eira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garc??a L??pez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovi??, N., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., H??tten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., L??pez, M., L??pez-Coto, R., L??pez-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Mart??nez, M., Mazin, D., Mender, S., Mi??anovi??, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavleti??, L., Pe??il, P., Perennes, C., Persic, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Rib??, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., nidari??, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suri??, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzi??, T., Teshima, M., Torres-Alb??, N., Tosti, L., Truzzi, S., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zari??, D., Jorstad, S. G., Marscher, A. P., Boccardi, B., Casadio, C., Hodgson, J., Kim, J. -Y., Krichbaum, T. P., L??hteenm??ki, A., Tornikoski, M., Traianou, E., Weaver, Z. R., Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Department of Electronics and Nanoengineering, Aalto-yliopisto, and Aalto University

Subjects
non-thermal, quasars: individual: PKS 1510−089, galaxies: active, relativistic processes, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies [radiation mechanisms], Photon, individual: PKS 1510−089 [quasars], Astrophysics::High Energy Astrophysical Phenomena, Flux, radiation mechanisms: non-thermal / quasars: individual: PKS 1510−089 / galaxies: active / relativistic processes, radiation mechanisms: non-thermal, quasars: individual: PKS 1510-089, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, law.invention, law, 0103 physical sciences, Galaxies: Active, Quasars: Individual: Pks 1510-089, Radiation mechanisms: Non-thermal, Relativistic processes, individual: PKS 1510-089 [quasars], MAGIC (telescope), 010303 astronomy & astrophysics, Physics, [PHYS]Physics [physics], 010308 nuclear & particles physics, Astronomy and Astrophysics, Quasar, Light curve, non-thermal [radiation mechanisms], relativistic processes [radiation mechanisms], Extragalactic background light, Space and Planetary Science, active [galaxies], ddc:520, Física nuclear, quasars: individual: PKS 1510���089, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope, Flare
Abstract

The flat spectrum radio quasar (FSRQ) PKS 1510−089 is known for its complex multiwavelength behaviour and it is one of only a few FSRQs detected in very-high-energy (VHE, E > 100 GeV) γ rays. The VHE γ-ray observations with H.E.S.S. and MAGIC in late May and early June 2016 resulted in the detection of an unprecedented flare, which revealed, for the first time, VHE γ-ray intranight variability for this source. While a common variability timescale of 1.5 h has been found, there is a significant deviation near the end of the flare, with a timescale of ∼20 min marking the cessation of the event. The peak flux is nearly two orders of magnitude above the low-level emission. For the first time, a curvature was detected in the VHE γ-ray spectrum of PKS 1510–089, which can be fully explained by the absorption on the part of the extragalactic background light. Optical R-band observations with ATOM revealed a counterpart of the γ-ray flare, even though the detailed flux evolution differs from the VHE γ-ray light curve. Interestingly, a steep flux decrease was observed at the same time as the cessation of the VHE γ-ray flare. In the high-energy (HE, E > 100 MeV) γ-ray band, only a moderate flux increase was observed with Fermi-LAT, while the HE γ-ray spectrum significantly hardens up to a photon index of 1.6. A search for broad-line region (BLR) absorption features in the γ-ray spectrum indicates that the emission region is located outside of the BLR. Radio very-long-baseline interferometry observations reveal a fast-moving knot interacting with a standing jet feature around the time of the flare. As the standing feature is located ∼50 pc from the black hole, the emission region of the flare may have been located at a significant distance from the black hole. If this is indeed a true correlation, the VHE γ rays must have been produced far down in the jet, where turbulent plasma crosses a standing shock., Astronomy & Astrophysics, 648, ISSN:0004-6361, ISSN:1432-0746

Published
2021
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38. Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign

Author

Masanori Nakamura, R. Shang, Abelardo Moralejo, A. Rugliancich, Marina Manganaro, Jun Liu, Monika Moscibrodzka, Andreas Specovius, V. Ramakrishnan, S. O'Brien, Michal Ostrowski, Luis C. Ho, Sera Markoff, D. Depaoli, I. Jung-Richardt, Manel Errando, Chiara Righi, S. Panny, Toshiaki Inada, Alexandra J. Tetarenko, Daniela Dorner, Norbert Wex, Nimesh A. Patel, Olivier Hervet, C. Arcaro, Alasdair E. Gent, Yu Wun Wong, Gaia Vanzo, Pierre Brun, Konstancja Satalecka, Stefan Funk, Lorenzo Bellizzi, Michael Lindqvist, Michele Doro, Felix Jankowsky, P. Kaaret, Nicholas R. MacDonald, Lang Cui, P. Temnikov, S. Patel, Sabrina Einecke, Manuel Artero, E. Moretti, Hope Boyce, M. Gaug, Charles F. Gammie, Iryna Lypova, Gisela N. Ortiz-León, Felix Aharonian, Colin J. Lonsdale, Buell T. Jannuzi, Gavin Rowell, M. Bryan, Yvonne Becherini, Aleksandar Popstefanija, M. Pohl, A. Marcowith, Jean-Pierre Ernenwein, H. Alyson Ford, Wystan Benbow, Karen E. Williamson, Daryl Haggard, Hambeleleni Ndiyavala, Tod R. Lauer, Arnaud Mares, Chaitanya Priyadarshi, Michael Punch, Helge Rottmann, J. Zorn, D. Dominis Prester, Bernd Schleicher, M. Minev, Hector Olivares, Ciriaco Goddi, S. Pita, J. Herrera, Alessia Spolon, Léa Jouvin, Na Wang, G. Martí-Devesa, Tomohiko Oka, Kirsty Feijen, E. Do Souto Espiñeira, Ralph Eatough, Johannes Veh, Stefano Gabici, Tomislav Terzić, D. Glawion, Gilles Fontaine, Bradford Benson, C. B. Rulten, Jenni Jormanainen, Jason SooHoo, Michael Titus, Jose Miguel Delgado, Marcos López-Moya, Freek Roelofs, Wlodek Bednarek, M. Lundy, Richard Anantua, Alessandra Lamastra, P. T. Reynolds, Vassil Verguilov, M. Lemoine-Goumard, G. Fichet de Clairfontaine, L. Di Venere, Michael Kreter, Jose Miguel Miranda, Alan L. Roy, Yating Chai, A. López-Oramas, M. Tluczykont, Jacek Niemiec, R. Konno, Tyler Trent, Olaf Reimer, Heino Falcke, Amanpreet Kaur, M. Panter, Narek Sahakyan, Kasper B. Schmidt, A. Carosi, K. Egberts, L. Maraschi, Stefan Cikota, V. Joshi, Koji Noda, Elisa Bernardini, Ye-Fei Yuan, Garrett K. Keating, Fumie Tazaki, Pawel Gliwny, M. Vazquez Acosta, Nicola Giglietto, M. Capasso, Vincent Piétu, Satoshi Fukami, Roman Gold, Elina Lindfors, Satoki Matsushita, A. Lemiere, F. Eichhorn, U. Katz, Yoshinori Yonekura, N. Shafi, Natalia Żywucka, Michael Kramer, M. Palatiello, Daniel Mazin, Samuel Timothy Spencer, Victoria Moreno, Oliver Porth, Julian Sitarek, Kazi L.J. Rygl, Wen Ping Lo, Geoffrey C. Bower, Ilje Cho, S. Fegan, Samuel Zouari, J. M. Paredes, V. Fallah Ramazani, Thomas Murach, Jim Hinton, R. J. White, F. Leone, S. Loporchio, M. de Naurois, Ed Fomalont, Bart Ripperda, Dominique Broguiere, J. Becerra González, Joseph R. Farah, Q. Feng, Andreas Quirrenbach, Taehyun Jung, C. Trichard, Masahiro Teshima, Domenico Tiziani, D. Malyshev, Richard Plambeck, Lynn D. Matthews, Avery E. Broderick, S. Kumar, T. J. Williamson, M. K. Daniel, Sylvia Zhu, P. J. Meintjes, Tjark Miener, Jodi Christiansen, Roger Brissenden, S. Sailer, Dmitry Khangulyan, David Paneque, Thomas P. Krichbaum, Sergey S. Savchenko, Angelo Ricarte, Riaan Steenkamp, T. Chand, J. Dyks, Francesco Dazzi, V. Baghmanyan, Zorawar Wadiasingh, Kazunori Akiyama, Stefan Ohm, C. Levy, Giovanna Ferrara, Makoto Inoue, Jhilik Majumdar, Nobuyuki Sakai, Dieter Horns, Jorge A. Preciado-López, Cornelia Müller, G. Hermann, Regis Terrier, A. J. Chromey, Dominic W. Pesce, Felix M. Pötzl, Mark Gurwell, Alejandro Cruz-Osorio, Ivan Marti-Vidal, Ben Prather, Tom Armstrong, Jongho Park, Matteo Cerruti, Ziri Younsi, Amy Furniss, Chih-Wei Locutus Huang, Lijing Shao, A. Djannati-Ataï, Shoko Koyama, D. Gottschall, P. Vincent, A. Brill, Kenji Toma, Antonios Nathanail, M. Nievas-Rosillo, M. Seglar-Arroyo, C. Delgado Mendez, Mahito Sasada, G. Busetto, Maciek Wielgus, Marcos Santander, Doosoo Yoon, D. A. Sanchez, Hiroki Okino, Christo Venter, Christiaan D. Brinkerink, James Ryan, S. Mićanović, Raquel Fraga-Encinas, Mark G. Rawlings, G. H. Sembroski, G. Principe, Xiang Liu, Karl Friedrich Schuster, Ronald Hesper, L. Sun, Ciro Bigongiari, Ramesh Narayan, M. Strzys, L. Mohrmann, Daniel R. van Rossum, Y. Ohtani, Wu Jiang, Luciano Rezzolla, Nu. Komin, V. A. Acciari, Katherine L. Bouman, Jürgen Besenrieder, Clemens Hoischen, A. A. Zdziarski, Antonio Tutone, Hung Yi Pu, A. Arbet Engels, J.-P. Lenain, A. De Angelis, Tomoya Hirota, R. J. García López, Carlo Romoli, Werner Hofmann, Tuomas Savolainen, Neil M. Nagar, Minfeng Gu, M. Karjalainen, Vitaly Neustroev, A. N. Otte, John F. C. Wardle, Tomoaki Oyama, Jongsoo Kim, Monica Barnard, J. Otero-Santos, R. D. Parsons, Pierre Christian, A. Priyana Noel, A. S. Seyffert, Shami Chatterjee, E. O. Angüner, David A. Green, Ramesh Karuppusamy, Zhiyuan Li, J. Devin, Dominik Elsaesser, F. Giordano, Santiago Ubach, Michael A. Nowak, Y. Kobayashi, F. Di Pierro, Iniyan Natarajan, A. Zech, M. Garczarczyk, Dmitriy Kostunin, Michael Janssen, Giacomo Bonnoli, Mariafelicia De Laurentis, Kuo Liu, G. Emery, Yutaro Kofuji, Antxon Alberdi, Marco Toliman Lucchini, R. A. Ong, Catherine Boisson, Daniel C. M. Palumbo, Stefan Klepser, Stefano Covino, Motoki Kino, Daniel Kerszberg, C. Armand, Maria Haupt, D. Zarić, K. Pfrang, R. López-Coto, M. Zacharias, Jae-Young Kim, Sheperd S. Doeleman, U. Barres de Almeida, Pratik Majumdar, M. V. Fonseca, Mosè Mariotti, G. Lamanna, Alexander Hahn, Sidika Merve Colak, R. J. Tuffs, B. Bi, Juan-Carlos Algaba, L. Oakes, D. Jankowsky, Y. Kajiwara, R. Marx, Bošnjak, John E. Barrett, Kotaro Niinuma, F. D'Ammando, Qingwen Wu, A. Yusafzai, Christian M. Fromm, Chi-kwan Chan, B. De Lotto, M. Kertzman, Manuela Mallamaci, H. Prokoph, Tadayuki Takahashi, Damir Lelas, Victor Doroshenko, E. Kasai, Lea Heckmann, Bong Won Sohn, Francesco Gabriele Saturni, Shiro Ikeda, T. Vuillaume, Laurent Loinard, G. Maurin, M. Füßling, Martin Will, Yi Chen, Gianluca Giavitto, Remo P. J. Tilanus, M. Spir-Jacob, Alessandro Montanari, Thomas Lohse, Tihomir Surić, J. van Scherpenberg, Per Friberg, He Sun, Luca Tosti, Kiyoaki Wajima, E. Ruiz-Velasco, Thomas Bylund, M. Balokovic, Feng Yuan, S. Nozaki, Mischa Breuhaus, Peter Galison, Y. A. Gallant, L. Olivera-Nieto, Dorota Sobczyńska, Maria-Isabel Bernardos, R. Rauth, Izumi Mizuno, Vincent L. Fish, S. G. Jorstad, Tomoki Saito, Giovanni Ceribella, Jacques Muller, J. P. Finley, Stefano Ansoldi, Boris Georgiev, Marcello Giroletti, Arturo I. Gómez-Ruiz, Karl M. Menten, Aristeidis Noutsos, P. deWilt, Junhan Kim, Alejandro Mus Mejías, Q. Remy, Dong-Jin Kim, P. G. Prada Moroni, Robert Wharton, Riccardo Paoletti, R. R. Prado, Zhi-Qiang Shen, S. Paiano, S. Chandra, Andrés Baquero, Anna Barnacka, Lucy Fortson, Wrijupan Bhattacharyya, Marc Ribó, E. de Ona Wilhelmi, Paul T. P. Ho, Yan-Rong Li, Derek Ward-Thompson, M. Scalici, G. Maneva, Constantin Steppa, Dimitrios Psaltis, A.M. Taylor, J. Damascene Mbarubucyeye, Daniel P. Marrone, Karl Mannheim, W. Boland, P. Morris, D. A. Prokhorov, M. Mohamed, Katsuaki Asano, Gernot Maier, Kotaro Moriyama, H. Odaka, M. Büchele, E. Pueschel, Kazuyoshi Nishijima, Christopher J. Duffy, H. M. Schutte, Camilla Maggio, Mark Kettenis, V. D'Elia, Saverio Lombardi, Ramprasad Rao, Ivica Puljak, R. Mirzoyan, V. Sahakian, Guang Yao Zhao, Adrian Biland, F. Werner, Rafal Moderski, Olivier Gentaz, Ullrich Schwanke, James M. Moran, S. Komossa, Yuzhu Cui, A. Jiménez-Rosales, Arash Roshanineshat, S. Ventura, Lindy Blackburn, David J. James, G. Hughes, Hidetoshi Kubo, Mansour Karami, José L. Gómez, P. Reichherzer, Davit Zargaryan, Paul Tiede, Koushik Chatterjee, Chunchong Ni, Roger Deane, Axel Donath, J. Rico, A. W. Chen, A. Fiasson, Jun Yi Koay, T. B. Humensky, Satoko Sawada-Satoh, Isak Delberth Davids, Alan P. Marscher, Alan E. E. Rogers, Rebecca Azulay, Kazuma Ishio, Paul M. Chesler, D. M. Strom, Carlo Vigorito, Marek Jamrozy, G. Pühlhofer, M. de Bony de Lavergne, Roberta Zanin, T. Schweizer, Elisa Prandini, Helene Sol, Rodolfo Carosi, M. Hörbe, T. Tavernier, Mareki Honma, M. Holler, Gordon T. Richards, Armelle Jardin-Blicq, Paolo Marchegiani, Sang-Sung Lee, D. Huber, Ashot Chilingarian, Nikola Godinovic, F. Ait Benkhali, Jason Dexter, Do-Young Byun, Anton Dmytriiev, Massimo Persic, Alicia Fattorini, L. Dirson, Cosimo Nigro, E. Roache, Sargis Gasparyan, S. Schwemmer, Sara Issaoun, Jessica Dempsey, Andrea Santangelo, Włodek Kluźniak, Mel Rose, Huib Jan van Langevelde, D. J. van der Walt, Elisabetta Liuzzo, A. Stamerra, John Hoang, Michelle Tsirou, Wolfgang Rhode, Tomohisa Kawashima, L. A. Antonelli, Carolin Wunderlich, Keiichi Asada, David A. Williams, Joachim Hahn, P. Moriarty, T. M. Crawford, P. Da Vela, L. Rinchiuso, E. Molina, F. Peter Schloerb, Lovro Pavletić, S. Steinmassl, Des Small, Christoph Deil, Stefano Menchiari, Dan Bintley, K. Nakashima, Alice Donini, David H. Hughes, Heinrich J. Völk, Mohanraj Senniappan, K. A. Farrell, M. Renaud, J. A. Barrio, Miriam Lucio Martinez, Rachel Simoni, P. T. O'Brien, E. Colombo, V. Barbosa Martins, M. Orienti, Efthalia Traianou, Lluis Font, B. Machado de Oliveira Fraga, Y. Suda, J. Neilsen, John Conway, Eduardo Ros, Gibwa Musoke, Tarek M. Hassan, J. Bolmont, A. Sinha, Halim Ashkar, M.-H. Grondin, Daniel Nieto, Lab Saha, Fabrizio Tavecchio, Hyunwook Ro, Michael H. Hecht, Markus Böttcher, Antonio Fuentes, Simone Mender, Moritz Hütten, Ue-Li Pen, Yosuke Mizuno, Gopal Narayanan, Lei Huang, H. Abdalla, M. A. Kastendieck, Nicola Marchili, I. Snidaric, S. Sánchez, G. Vasileiadis, Kari Nilsson, Alexander W. Raymond, Greg Lindahl, Gregory Desvignes, Sascha Trippe, Sanae Inoue, Giacomo D'Amico, W. Jin, B. van Soelen, Andrew Chael, Anne Kathrin Baczko, Shunsuke Sakurai, L. Giunti, A. Nayerhoda, Walter Alef, Jamie Holder, Stefano Truzzi, Pablo Peñil, M. J. Lang, Francois Brun, Frank M. Rieger, V. Vitale, George N. Wong, Jirong Mao, S. Caroff, J. Kushida, André Young, Ru-Sen Lu, Daniel Morcuende, Jose Luis Contreras, Kazuhiro Hada, Juan Cortina, C. van Eldik, Pablo Torne, Raymond Blundell, Jarred Gershon Green, C. B. Adams, James M. Cordes, Jonathan Weintroub, Q. Piel, A. Berti, James E. M. Watson, G. Peron, Ken Young, Garret Cotter, Dario Hrupec, Jonathan Mackey, K. Ragan, John E. Carlstrom, Michael Backes, Tim Holch, D. Hadasch, Stawarz, F. Niederwanger, Feryal Özel, Lia Medeiros, A. Weinstein, Mitsunari Takahashi, Manuel Delfino, C. Y. Kuo, Aviad Levis, Francesco Longo, K. Kosack, Konrad Bernlöhr, Jacco Vink, C. Moore, Michael Bremer, Jim Davies, Jadyn Anczarski, Patrick M. Koch, Sabrina Casanova, Ming-Tang Chen, B. Peyaud, Christian Stegmann, Stefan Wagner, C. Perennes, Yasunobu Uchiyama, David Kieda, Chet Ruszczyk, Hiroshi Nagai, M. Curyło, Andrei Lobanov, Ana Babić, E. Moulin, Tomasz Bulik, Britton Jeter, I. Vovk, Martin Makariev, C. van Rensburg, Oscar Blanch, Rocco Lico, Silke Britzen, Misao Sasaki, A. Reimer, V. Poireau, R. Adam, David Ball, Mark Reynolds, D. Miceli, John L. Quinn, Roberto Garcia, J. F. Glicenstein, D. Ribeiro, A. Wierzcholska, Geoffrey B. Crew, Bruno Khelifi, David Sánchez-Arguelles, Ilse van Bemmel, Michael D. Johnson, J. Anton Zensus, Dominik Baack, Manuel Meyer, E. V. Kravchenko, I. Jiménez, Thomas Bronzwaer, Reshmi Mukherjee, D. Berge, C. Giuri, Kleopas Shiningayamwe, Shan Shan Zhao, Yuki Iwamura, A. D. Falcone, Lenka Tomankova, Carsten Kramer, Jan Wagner, Christian Fruck, B. Rudak, Jordy Davelaar, V. Marandon, K. Katarzyński, Roberto Neri, The EHT MWL Science Working Group, Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Instituto de RadioAstronomía Milimétrica (IRAM), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Groupe de Physique des Solides (GPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL), Event Horizon Telescope, Fermi-LAT, H.E.S.S., MAGIC, VERITAS, EAVN, High Energy Astrophys. & Astropart. Phys (API, FNWI), API Other Research (FNWI), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Algaba, Jc, Anczarski, J, Asada, K, Balokovic, M, Chandra, S, Cui, Yz, Falcone, Ad, Giroletti, M, Goddi, C, Hada, K, Haggard, D, Jorstad, S, Kaur, A, Kawashima, T, Keating, G, Kim, Jy, Kino, M, Komossa, S, Kravchenko, Ev, Krichbaum, Tp, Lee, S, Lu, R, Lucchini, M, Markoff, S, Neilsen, J, Nowak, Ma, Park, J, Principe, G, Ramakrishnan, V, Reynolds, Mt, Sasada, M, Savchenko, S, Williamson, Ke, Longo, F, Et, Al., University of Michigan, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, Algaba, J. C., Anczarski, J., Asada, K., Balokovic, M., Chandra, S., Cui, Y. -Z., Falcone, A. D., Giroletti, M., Goddi, C., Hada, K., Haggard, D., Jorstad, S., Kaur, A., Kawashima, T., Keating, G., Kim, J. -Y., Kino, M., Komossa, S., Kravchenko, E. V., Krichbaum, T. P., Lee, S. -S., Lu, R. -S., Lucchini, M., Markoff, S., Neilsen, J., Nowak, M. A., Park, J., Principe, G., Ramakrishnan, V., Reynolds, M. T., Sasada, M., Savchenko, S. S., Williamson, K. E., Akiyama, K., Alberdi, A., Alef, W., Anantua, R., Azulay, R., Baczko, A. -K., Ball, D., Barrett, J., Bintley, D., Benson, B. A., Blackburn, L., Blundell, R., Boland, W., Bouman, K. L., Bower, G. C., Boyce, H., Bremer, M., Brinkerink, C. D., Brissenden, R., Britzen, S., Broderick, A. E., Broguiere, D., Bronzwaer, T., Byun, D. -Y., Carlstrom, J. E., Chael, A., Chan, C. -K., Chatterjee, S., Chatterjee, K., Chen, M. -T., Chen, Y., Chesler, P. M., Cho, I., Christian, P., Conway, J. E., Cordes, J. M., Crawford, T. M., Crew, G. B., Cruz-Osorio, A., Davelaar, J., De Laurentis, M., Deane, R., Dempsey, J., Desvignes, G., Dexter, J., Doeleman, S. S., Eatough, R. P., Falcke, H., Farah, J., Fish, V. L., Fomalont, E., Ford, H. A., Fraga-Encinas, R., Friberg, P., Fromm, C. M., Fuentes, A., Galison, P., Gammie, C. F., Garcia, R., Gentaz, O., Georgiev, B., Gold, R., Gomez, J. L., Gomez-Ruiz, A. I., Gu, M., Gurwell, M., Hecht, M. H., Hesper, R., Ho, L. C., Ho, P., Honma, M., Huang, C. -W. L., Huang, L., Hughes, D. H., Ikeda, S., Inoue, M., Issaoun, S., James, D. J., Jannuzi, B. T., Janssen, M., Jeter, B., Jiang, W., Jimenez-Rosales, A., Johnson, M. D., Jung, T., Karami, M., Karuppusamy, R., Kettenis, M., Kim, D. -J., Kim, J., Koay, J. Y., Kofuji, Y., Koch, P. M., Koyama, S., Kramer, M., Kramer, C., Kuo, C. -Y., Lauer, T. R., Levis, A., Li, Y. -R., Li, Z., Lindqvist, M., Lico, R., Lindahl, G., Liu, J., Liu, K., Liuzzo, E., Lo, W. -P., Lobanov, A. P., Loinard, L., Lonsdale, C., Macdonald, N. R., Mao, J., Marchili, N., Marrone, D. P., Marscher, A. P., Marti-Vidal, I., Matsushita, S., Matthews, L. D., Medeiros, L., Menten, K. M., Mizuno, I., Mizuno, Y., Moran, J. M., Moriyama, K., Moscibrodzka, M., Muller, C., Musoke, G., Mejias, A. M., Nagai, H., Nagar, N. M., Nakamura, M., Narayan, R., Narayanan, G., Natarajan, I., Nathanail, A., Neri, R., Ni, C., Noutsos, A., Okino, H., Olivares, H., Ortiz-Leon, G. N., Oyama, T., Ozel, F., Palumbo, D. C. M., Patel, N., Pen, U. -L., Pesce, D. W., Pietu, V., Plambeck, R., Popstefanija, A., Porth, O., Potzl, F. M., Prather, B., Preciado-Lopez, J. A., Psaltis, D., Pu, H. -Y., Rao, R., Rawlings, M. G., Raymond, A. W., Rezzolla, L., Ricarte, A., Ripperda, B., Roelofs, F., Rogers, A., Ros, E., Rose, M., Roshanineshat, A., Rottmann, H., Roy, A. L., Ruszczyk, C., Rygl, K. L. J., Sanchez, S., Sanchez-Arguelles, D., Savolainen, T., Schloerb, F. P., Schuster, K. -F., Shao, L., Shen, Z., Small, D., Sohn, B. W., Soohoo, J., Sun, H., Tazaki, F., Tetarenko, A. J., Tiede, P., Tilanus, R. P. J., Titus, M., Toma, K., Torne, P., Trent, T., Traianou, E., Trippe, S., Van Bemmel, I., Van Langevelde, H. J., Van Rossum, D. R., Wagner, J., Ward-Thompson, D., Wardle, J., Weintroub, J., Wex, N., Wharton, R., Wielgus, M., Wong, G. N., Wu, Q., Yoon, D., Young, A., Young, K., Younsi, Z., Yuan, F., Yuan, Y. -F., Zensus, J. A., Zhao, G. -Y., Zhao, S. -S., D'Ammando, F., Orienti, M., Abdalla, H., Adam, R., Aharonian, F., Benkhali, F. A., Anguner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlohr, K., Bi, B., Bottcher, M., Boisson, C., Bolmont, J., De Bony De Lavergne, M., Breuhaus, M., Brun, F., Brun, P., Bryan, M., Buchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chen, A., Cotter, G., Curylo, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Atai, A., Dmytriiev, A., Donath, A., Doroshenko, V., Duffy, C., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., De Clairfontaine, G. F., Fontaine, G., Funk, S., Fussling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Horbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kasai, E., Kastendieck, M. A., Katarzynski, K., Katz, U., Khangulyan, D., Khelifi, B., Klepser, S., Kluzniak, W., Komin, N., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemiere, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Marti-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., De Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., De Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Noel, A. P., Prokhorov, D. A., Prokoph, H., Puhlhofer, G., Punch, M., Quirrenbach, A., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., Van Der Walt, D. J., Van Eldik, C., Van Rensburg, C., Van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Volk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Y. W., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zorn, J., Zouari, S., Zywucka, N., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. A., Artero, M., Asano, K., Baack, D., Babic, A., Baquero, A., De Almeida, U. B., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovic, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jimenez, I., Jormanainen, J., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez-Coto, R., Lopez-Moya, M., Lopez-Oramas, A., Loporchio, S., Machado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Menchiari, S., Mender, S., Micanovic, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletic, L., Penil, P., Perennes, C., Persic, M., Moroni, P. G. P., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Zaric, D., Adams, C. B., Benbow, W., Brill, A., Capasso, M., Christiansen, J. L., Chromey, A. J., Daniel, M. K., Errando, M., Farrell, K. A., Feng, Q., Finley, J. P., Fortson, L., Furniss, A., Gent, A., Giuri, C., Hassan, T., Hervet, O., Holder, J., Hughes, G., Humensky, T. B., Jin, W., Kaaret, P., Kertzman, M., Kieda, D., Kumar, S., Lang, M. J., Lundy, M., Maier, G., Moriarty, P., Mukherjee, R., Nieto, D., Nievas-Rosillo, M., O'Brien, S., Ong, R. A., Otte, A. N., Patel, S., Pfrang, K., Pohl, M., Prado, R. R., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Ribeiro, D., Richards, G. T., Roache, E., Rulten, C., Ryan, J. L., Santander, M., Sembroski, G. H., Shang, R., Weinstein, A., Williams, D. A., Williamson, T. J., Hirota, T., Cui, L., Niinuma, K., Ro, H., Sakai, N., Sawada-Satoh, S., Wajima, K., Wang, N., Liu, X., Yonekura, Y., German Research Foundation, Istituto Nazionale di Fisica Nucleare, Swiss National Science Foundation, Ministerio de Ciencia, Innovación y Universidades (España), Department of Atomic Energy (India), University of Tokyo, Japan Society for the Promotion of Science, Ministry of Education and Scientific Research (Romania), Academy of Finland, La Caixa, Croatian Science Foundation, Generalitat de Catalunya, Polish National Agency for Academic Exchange, University of Rijeka, Department of Energy (US), Smithsonian Institution, Astronomy, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)

Subjects
Accretion, 010504 meteorology & atmospheric sciences, Astronomy, Flux, Astrophysics, 7. Clean energy, 01 natural sciences, Active galactic nuclei, Radio cores, Low-luminosity active galactic nuclei, High energy astrophysics, Astrophysical black holes, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, astro-ph.HE, Radio core, Accretion (meteorology), 520 Astronomie und zugeordnete Wissenschaften, Low-luminosity, active galactic nuclei, Astrophysical black hole, astro-ph.CO, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Active galactic nucleus, High-energy astronomy, astro-ph.GA, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, F500, Astrophysics::Cosmology and Extragalactic Astrophysics, High energy astrophysic, 0103 physical sciences, Very-long-baseline interferometry, ddc:530, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Event Horizon Telescope, Supermassive black hole, Astronomy and Astrophysics, 530 Physik, Galaxy, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), ddc:520, HESS - Abteilung Hinton, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

Full list of authors: EHT MWL Science Working Group; Algaba, J. C.; Anczarski, J.; Asada, K.; Baloković, M.; Chandra, S.; Cui, Y. -Z.; Falcone, A. D.; Giroletti, M.; Goddi, C.; Hada, K.; Haggard, D.; Jorstad, S.; Kaur, A.; Kawashima, T.; Keating, G.; Kim, J. -Y.; Kino, M.; Komossa, S.; Kravchenko, E. V.; Krichbaum, T. P.; Lee, S. -S.; Lu, R. -S.; Lucchini, M.; Markoff, S.; Neilsen, J.; Nowak, M. A.; Park, J.; Principe, G.; Ramakrishnan, V.; Reynolds, M. T.; Sasada, M.; Savchenko, S. S.; Williamson, K. E.; Event Horizon Telescope Collaboration; Akiyama, Kazunori; Alberdi, Antxon; Alef, Walter; Anantua, Richard; Azulay, Rebecca; Baczko, Anne-Kathrin; Ball, David; Barrett, John; Bintley, Dan; Benson, Bradford A.; Blackburn, Lindy; Blundell, Raymond; Boland, Wilfred; Bouman, Katherine L.; Bower, Geoffrey C.; Boyce, Hope; Bremer, Michael; Brinkerink, Christiaan D.; Brissenden, Roger; Britzen, Silke; Broderick, Avery E.; Broguiere, Dominique; Bronzwaer, Thomas; Byun, Do-Young; Carlstrom, John E.; Chael, Andrew; Chan, Chi-Kwan; Chatterjee, Shami; Chatterjee, Koushik; Chen, Ming-Tang; Chen, Yongjun; Chesler, Paul M.; Cho, Ilje; Christian, Pierre; Conway, John E.; Cordes, James M.; Crawford, Thomas M.; Crew, Geoffrey B.; Cruz-Osorio, Alejandro; Davelaar, Jordy; de Laurentis, Mariafelicia; Deane, Roger; Dempsey, Jessica; Desvignes, Gregory; Dexter, Jason; Doeleman, Sheperd S.; Eatough, Ralph P.; Falcke, Heino; Farah, Joseph; Fish, Vincent L.; Fomalont, Ed; Ford, H. Alyson; Fraga-Encinas, Raquel; Friberg, Per; Fromm, Christian M.; Fuentes, Antonio; Galison, Peter; Gammie, Charles F.; García, Roberto; Gentaz, Olivier; Georgiev, Boris; Gold, Roman; Gómez, José L.; Gómez-Ruiz, Arturo I.; Gu, Minfeng; Gurwell, Mark; Hecht, Michael H.; Hesper, Ronald; Ho, Luis C.; Ho, Paul; Honma, Mareki; Huang, Chih-Wei L.; Huang, Lei; Hughes, David H.; Ikeda, Shiro; Inoue, Makoto; Issaoun, Sara; James, David J.; Jannuzi, Buell T.; Janssen, Michael; Jeter, Britton; Jiang, Wu; Jiménez-Rosales, Alejandra; Johnson, Michael D.; Jung, Taehyun; Karami, Mansour; Karuppusamy, Ramesh; Kettenis, Mark; Kim, Dong-Jin; Kim, Jongsoo; Kim, Junhan; Koay, Jun Yi; Kofuji, Yutaro; Koch, Patrick M.; Koyama, Shoko; Kramer, Michael; Kramer, Carsten; Kuo, Cheng-Yu; Lauer, Tod R.; Levis, Aviad; Li, Yan-Rong; Li, Zhiyuan; Lindqvist, Michael; Lico, Rocco; Lindahl, Greg; Liu, Jun; Liu, Kuo; Liuzzo, Elisabetta; Lo, Wen-Ping; Lobanov, Andrei P.; Loinard, Laurent; Lonsdale, Colin; MacDonald, Nicholas R.; Mao, Jirong; Marchili, Nicola; Marrone, Daniel P.; Marscher, Alan P.; Martí-Vidal, Iván; Matsushita, Satoki; Matthews, Lynn D.; Medeiros, Lia; Menten, Karl M.; Mizuno, Izumi; Mizuno, Yosuke; Moran, James M.; Moriyama, Kotaro; Moscibrodzka, Monika; Müller, Cornelia; Musoke, Gibwa; Mejías, Alejandro Mus; Nagai, Hiroshi; Nagar, Neil M.; Nakamura, Masanori; Narayan, Ramesh; Narayanan, Gopal; Natarajan, Iniyan; Nathanail, Antonios; Neri, Roberto; Ni, Chunchong; Noutsos, Aristeidis; Okino, Hiroki; Olivares, Héctor; Ortiz-León, Gisela N.; Oyama, Tomoaki; Özel, Feryal; Palumbo, Daniel C. M.; Patel, Nimesh; Pen, Ue-Li; Pesce, Dominic W.; Piétu, Vincent; Plambeck, Richard; Popstefanija, Aleksandar; Porth, Oliver; Pötzl, Felix M.; Prather, Ben; Preciado-López, Jorge A.; Psaltis, Dimitrios; Pu, Hung-Yi; Rao, Ramprasad; Rawlings, Mark G.; Raymond, Alexander W.; Rezzolla, Luciano; Ricarte, Angelo; Ripperda, Bart; Roelofs, Freek; Rogers, Alan; Ros, Eduardo; Rose, Mel; Roshanineshat, Arash; Rottmann, Helge; Roy, Alan L.; Ruszczyk, Chet; Rygl, Kazi L. J.; Sánchez, Salvador; Sánchez-Arguelles, David; Savolainen, Tuomas; Schloerb, F. Peter; Schuster, Karl-Friedrich; Shao, Lijing; Shen, Zhiqiang; Small, Des; Sohn, Bong Won; Soohoo, Jason; Sun, He; Tazaki, Fumie; Tetarenko, Alexandra J.; Tiede, Paul; Tilanus, Remo P. J.; Titus, Michael; Toma, Kenji; Torne, Pablo; Trent, Tyler; Traianou, Efthalia; Trippe, Sascha; van Bemmel, Ilse; van Langevelde, Huib Jan; van Rossum, Daniel R.; Wagner, Jan; Ward-Thompson, Derek; Wardle, John; Weintroub, Jonathan; Wex, Norbert; Wharton, Robert; Wielgus, Maciek; Wong, George N.; Wu, Qingwen; Yoon, Doosoo; Young, André; Young, Ken; Younsi, Ziri; Yuan, Feng; Yuan, Ye-Fei; Zensus, J. Anton; Zhao, Guang-Yao; Zhao, Shan-Shan; Fermi Large Area Telescope Collaboration; Principe, G.; Giroletti, M.; D'Ammando, F.; Orienti, M.; H. E. S. S. Collaboration; Abdalla, H.; Adam, R.; Aharonian, F.; Benkhali, F. Ait; Angüner, E. O.; Arcaro, C.; Armand, C.; Armstrong, T.; Ashkar, H.; Backes, M.; Baghmanyan, V.; Barbosa Martins, V.; Barnacka, A.; Barnard, M.; Becherini, Y.; Berge, D.; Bernlöhr, K.; Bi, B.; Böttcher, M.; Boisson, C.; Bolmont, J.; de Lavergne, M. De Bony; Breuhaus, M.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Bylund, T.; Caroff, S.; Carosi, A.; Casanova, S.; Chand, T.; Chen, A.; Cotter, G.; Curyło, M.; Damascene Mbarubucyeye, J.; Davids, I. D.; Davies, J.; Deil, C.; Devin, J.; Dewilt, P.; Dirson, L.; Djannati-Ataï, A.; Dmytriiev, A.; Donath, A.; Doroshenko, V.; Duffy, C.; Dyks, J.; Egberts, K.; Eichhorn, F.; Einecke, S.; Emery, G.; Ernenwein, J. -P.; Feijen, K.; Fegan, S.; Fiasson, A.; de Clairfontaine, G. Fichet; Fontaine, G.; Funk, S.; Füßling, M.; Gabici, S.; Gallant, Y. A.; Giavitto, G.; Giunti, L.; Glawion, D.; Glicenstein, J. F.; Gottschall, D.; Grondin, M. -H.; Hahn, J.; Haupt, M.; Hermann, G.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Hörbe, M.; Horns, D.; Huber, D.; Jamrozy, M.; Jankowsky, D.; Jankowsky, F.; Jardin-Blicq, A.; Joshi, V.; Jung-Richardt, I.; Kasai, E.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Khangulyan, D.; Khélifi, B.; Klepser, S.; Kluźniak, W.; Komin, Nu.; Konno, R.; Kosack, K.; Kostunin, D.; Kreter, M.; Lamanna, G.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J. -P.; Levy, C.; Lohse, T.; Lypova, I.; Mackey, J.; Majumdar, J.; Malyshev, D.; Malyshev, D.; Marandon, V.; Marchegiani, P.; Marcowith, A.; Mares, A.; Martí-Devesa, G.; Marx, R.; Maurin, G.; Meintjes, P. J.; Meyer, M.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Montanari, A.; Moore, C.; Morris, P.; Moulin, E.; Muller, J.; Murach, T.; Nakashima, K.; Nayerhoda, A.; de Naurois, M.; Ndiyavala, H.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Ohm, S.; Olivera-Nieto, L.; de Ona Wilhelmi, E.; Ostrowski, M.; Panter, M.; Panny, S.; Parsons, R. D.; Peron, G.; Peyaud, B.; Piel, Q.; Pita, S.; Poireau, V.; Noel, A. Priyana; Prokhorov, D. A.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Rauth, R.; Reichherzer, P.; Reimer, A.; Reimer, O.; Remy, Q.; Renaud, M.; Rieger, F.; Rinchiuso, L.; Romoli, C.; Rowell, G.; Rudak, B.; Ruiz-Velasco, E.; Sahakian, V.; Sailer, S.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Scalici, M.; Schutte, H. M.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Senniappan, M.; Seyffert, A. S.; Shafi, N.; Shiningayamwe, K.; Simoni, R.; Sinha, A.; Sol, H.; Specovius, A.; Spencer, S.; Spir-Jacob, M.; Stawarz, Ł.; Sun, L.; Steenkamp, R.; Stegmann, C.; Steinmassl, S.; Steppa, C.; Takahashi, T.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tiziani, D.; Tluczykont, M.; Tomankova, L.; Trichard, C.; Tsirou, M.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Vincent, P.; Vink, J.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Watson, J.; Werner, F.; White, R.; Wierzcholska, A.; Wong, Yu Wun; Yusafzai, A.; Zacharias, M.; Zanin, R.; Zargaryan, D.; Zdziarski, A. A.; Zech, A.; Zhu, S. J.; Zorn, J.; Zouari, S.; Żywucka, N.; MAGIC Collaboration; Acciari, V. A.; Ansoldi, S.; Antonelli, L. A.; Engels, A. Arbet; Artero, M.; Asano, K.; Baack, D.; Babić, A.; Baquero, A.; de Almeida, U. Barres; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Bellizzi, L.; Bernardini, E.; Bernardos, M.; Berti, A.; Besenrieder, J.; Bhattacharyya, W.; Bigongiari, C.; Biland, A.; Blanch, O.; Bonnoli, G.; Bošnjak, Ž.; Busetto, G.; Carosi, R.; Ceribella, G.; Cerruti, M.; Chai, Y.; Chilingarian, A.; Cikota, S.; Colak, S. M.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; D'Elia, V.; da Vela, P.; Dazzi, F.; de Angelis, A.; de Lotto, B.; Delfino, M.; Delgado, J.; Delgado Mendez, C.; Depaoli, D.; di Pierro, F.; di Venere, L.; Do Souto Espiñeira, E.; Dominis Prester, D.; Donini, A.; Dorner, D.; Doro, M.; Elsaesser, D.; Ramazani, V. Fallah; Fattorini, A.; Ferrara, G.; Fonseca, M. V.; Font, L.; Fruck, C.; Fukami, S.; García López, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinović, N.; Green, J. G.; Green, D.; Hadasch, D.; Hahn, A.; Heckmann, L.; Herrera, J.; Hoang, J.; Hrupec, D.; Hütten, M.; Inada, T.; Inoue, S.; Ishio, K.; Iwamura, Y.; Jiménez, I.; Jormanainen, J.; Jouvin, L.; Kajiwara, Y.; Karjalainen, M.; Kerszberg, D.; Kobayashi, Y.; Kubo, H.; Kushida, J.; Lamastra, A.; Lelas, D.; Leone, F.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, R.; López-Moya, M.; López-Oramas, A.; Loporchio, S.; Machado de Oliveira Fraga, B.; Maggio, C.; Majumdar, P.; Makariev, M.; Mallamaci, M.; Maneva, G.; Manganaro, M.; Mannheim, K.; Maraschi, L.; Mariotti, M.; Martínez, M.; Mazin, D.; Menchiari, S.; Mender, S.; Mićanović, S.; Miceli, D.; Miener, T.; Minev, M.; Miranda, J. M.; Mirzoyan, R.; Molina, E.; Moralejo, A.; Morcuende, D.; Moreno, V.; Moretti, E.; Neustroev, V.; Nigro, C.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Oka, T.; Otero-Santos, J.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Pavletić, L.; Peñil, P.; Perennes, C.; Persic, M.; Moroni, P. G. Prada; Prandini, E.; Priyadarshi, C.; Puljak, I.; Rhode, W.; Ribó, M.; Rico, J.; Righi, C.; Rugliancich, A.; Saha, L.; Sahakyan, N.; Saito, T.; Sakurai, S.; Satalecka, K.; Saturni, F. G.; Schleicher, B.; Schmidt, K.; Schweizer, T.; Sitarek, J.; Šnidarić, I.; Sobczynska, D.; Spolon, A.; Stamerra, A.; Strom, D.; Strzys, M.; Suda, Y.; Surić, T.; Takahashi, M.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Teshima, M.; Tosti, L.; Truzzi, S.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vanzo, G.; Vazquez Acosta, M.; Ventura, S.; Verguilov, V.; Vigorito, C. F.; Vitale, V.; Vovk, I.; Will, M.; Wunderlich, C.; Zarić, D.; VERITAS Collaboration; Adams, C. B.; Benbow, W.; Brill, A.; Capasso, M.; Christiansen, J. L.; Chromey, A. J.; Daniel, M. K.; Errando, M.; Farrell, K. A.; Feng, Q.; Finley, J. P.; Fortson, L.; Furniss, A.; Gent, A.; Giuri, C.; Hassan, T.; Hervet, O.; Holder, J.; Hughes, G.; Humensky, T. B.; Jin, W.; Kaaret, P.; Kertzman, M.; Kieda, D.; Kumar, S.; Lang, M. J.; Lundy, M.; Maier, G.; Moriarty, P.; Mukherjee, R.; Nieto, D.; Nievas-Rosillo, M.; O'Brien, S.; Ong, R. A.; Otte, A. N.; Patel, S.; Pfrang, K.; Pohl, M.; Prado, R. R.; Pueschel, E.; Quinn, J.; Ragan, K.; Reynolds, P. T.; Ribeiro, D.; Richards, G. T.; Roache, E.; Rulten, C.; Ryan, J. L.; Santander, M.; Sembroski, G. H.; Shang, R.; Weinstein, A.; Williams, D. A.; Williamson, T. J.; Eavn Collaboration; Hirota, Tomoya; Cui, Lang; Niinuma, Kotaro; Ro, Hyunwook; Sakai, Nobuyuki; Sawada-Satoh, Satoko; Wajima, Kiyoaki; Wang, Na; Liu, Xiang; Yonekura, Yoshinori, In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded., The financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovacion (MICINN) (FPA2017-87859-P, FPA2017-85668-P, FPA2017- 82729-C6-5-R, FPA2017-90566-REDC, PID2019-104114RBC31, PID2019-104114RB-C32, PID2019-105510GB-C31,PID 2019-107847RB-C41, PID2019-107847RB-C42, PID2019- 107988GB-C22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-268/16.12.2019 and the Academy of Finland grant No. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and CEX2019- 000920-S, and “Maria de Maeztu” CEX2019-000918-M, the Unidad de Excelencia “Maria de Maeztu” MDM-2015-0509- 18-2 and the “la Caixa” Foundation (fellowship LCF/BQ/ PI18/11630012) and by the CERCA program of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02; by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3; the Polish National Research Centre grant UMO-2016/22/M/ST9/00382; and by the Brazilian MCTIC, CNPq, and FAPERJ. This research is supported by grants from the U.S. Department of Energy Office of Science, the U.S. National Science Foundation and the Smithsonian Institution, by NSERC in Canada, and by the Helmholtz Association in Germany. This research used resources provided by the Open Science Grid, which is supported by the National Science Foundation and the U.S. Department of Energy’s Office of Science, and resources of the National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility operated under Contract No. DE-AC02-05CH11231. We acknowledge the excellent work of the technical support staff at the Fred Lawrence Whipple Observatory and at the collaborating institutions in the construction and operation of the instrument.

Published
2021
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40. Inhibition of Mycobacterium tuberculosis InhA: Design, synthesis and evaluation of new di-triclosan derivatives

Author

Tom Armstrong, Luke J. Alderwick, Neil R. Thomas, Alice Lanne, and Malcolm Lamont

Subjects
Stereochemistry, Clinical Biochemistry, Triazole, Antitubercular Agents, Pharmaceutical Science, Microbial Sensitivity Tests, 01 natural sciences, Biochemistry, Mycobacterium tuberculosis, chemistry.chemical_compound, Structure-Activity Relationship, Bacterial Proteins, Tuberculosis, Multidrug-Resistant, Drug Discovery, medicine, Enzyme Inhibitors, IC50, Molecular Biology, chemistry.chemical_classification, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, INHA, Isoniazid, Organic Chemistry, biology.organism_classification, Enzyme assay, Triclosan, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Drug Design, biology.protein, Molecular Medicine, Oxidoreductases, medicine.drug
Abstract

Multi-drug resistant tuberculosis (MDR-TB) represents a growing problem for global healthcare systems. In addition to 1.3 million deaths in 2018, the World Health Organisation reported 484,000 new cases of MDR-TB. Isoniazid is a key anti-TB drug that inhibits InhA, a crucial enzyme in the cell wall biosynthesis pathway and identical in Mycobacterium tuberculosis and M. bovis. Isoniazid is a pro-drug which requires activation by the enzyme KatG, mutations in KatG prevent activation and confer INH-resistance. ‘Direct inhibitors’ of InhA are attractive as they would circumvent the main clinically observed resistance mechanisms. A library of new 1,5-triazoles, designed to mimic the structures of both triclosan molecules uniquely bound to InhA have been synthesised. The inhibitory activity of these compounds was evaluated using isolated enzyme assays with 2 (5-chloro-2-(4-(5-(((4-(4-chloro-2-hydroxyphenoxy)benzyl)oxy)methyl)-1H-1,2,3-triazol-1-yl)phenoxy)phenol) exhibiting an IC50 of 5.6 µM. Whole-cell evaluation was also performed, with 11 (5-chloro-2-(4-(5-(((4-(cyclopropylmethoxy)benzyl)oxy)methyl)-1H-1,2,3-triazol-1-yl)phenoxy)phenol) showing the greatest potency, with an MIC99 of 12.9 µM against M. bovis.

Published
2020

41. Appendicitis with direct fistulation into the liver: a forgotten cause of pyogenic liver abscess

Author

Sam Dluzewski, Dominic Yu, and Tom Armstrong

Subjects
Pyogenic liver abscess, medicine.medical_specialty, business.industry, General surgery, Acute appendicitis, medicine, Haematogenous spread, Context (language use), Case Report, General Medicine, medicine.disease, business, Appendicitis
Abstract

Pyogenic liver abscess typically occurs secondary to biliary or haematogenous spread of organisms. In the context of acute appendicitis, abscesses generally occur due to haematogenous spread through the mesenteric vasculature. Historically, few cases of direct intra-abdominal spread have been reported but this has become vanishingly rare since the development of antibiotic therapy with no recorded cases in a search of over 900 cases in the literature.

Published
2020

42. Very high energy γ-ray emission from two blazars of unknown redshift and upper limits on their distance

Author

Johan Bregeon, J. Devin, D. Gottschall, Zorawar Wadiasingh, Tadayuki Takahashi, R. J. White, Łukasz Stawarz, V. Barbosa Martins, H.M. Schutte, Maria Haupt, Thomas Lohse, Victor Doroshenko, Domenico Tiziani, M. Lemoine-Goumard, C. Arcaro, Michal Ostrowski, J.-P. Lenain, M. Panter, U. Katz, Michael Kreter, Jim Hinton, A. Lemiere, F. Eichhorn, M. de Naurois, R. Adam, Stefan Ohm, James Davies, Stefan Funk, Alicja Wierzcholska, Michael Punch, S. Sailer, Dmitry Khangulyan, D. A. Sanchez, H. Abdalla, M. Zacharias, M. A. Kastendieck, Stefano Gabici, T. Vuillaume, Rafal Moderski, R. J. Tuffs, N. Shafi, Natalia Żywucka, A. Fiasson, Samuel Timothy Spencer, M. Spir-Jacob, M. Seglar-Arroyo, Alexandre Marcowith, A. Santangelo, V. Baghmanyan, Nu. Komin, T. Chand, Jhilik Majumdar, J. Dyks, V. Joshi, P. deWilt, F. Ait Benkhali, L. Oakes, J. Bolmont, Mischa Breuhaus, Heike Prokoph, E. O. Angüner, G. Lamanna, Anton Dmytriiev, Davit Zargaryan, Ruizhi Yang, Q. Piel, Dmitriy Kostunin, Krzysztof Katarzynski, Catherine Boisson, Axel Donath, A. W. Chen, S. Caroff, V. Sahakian, F. Werner, G. Pühlhofer, Arnaud Mares, D. Jankowsky, R. Marx, M. Füßling, S. Schwemmer, Q. Remy, R. Rauth, Dieter Horns, G. Maurin, Y. A. Gallant, Marek Jamrozy, Clemens Hoischen, A. A. Zdziarski, A.S. Seyffert, R. Konno, M. Barnard, S. Nakashima, Anna Barnacka, Gavin Rowell, M. Mohamed, Riaan Steenkamp, M. Bryan, Helene Sol, A. Carosi, M. Hörbe, Sylvia Zhu, P. J. Meintjes, Michelle Tsirou, Christian Stegmann, Stefan Wagner, E. de Oña Wilhelmi, D. Malyshev, S. Raab, Yasunobu Uchiyama, J. Zorn, L. Rinchiuso, Isak Delberth Davids, Kirsty Feijen, Frank M. Rieger, Pierre Brun, R. D. Parsons, T. Tavernier, Jean-Pierre Ernenwein, I. Jung-Richardt, Jason John Watson, Roberta Zanin, L. Mohrmann, V. Poireau, Gianluca Giavitto, C. van Rensburg, S. Pita, Johannes Veh, K. Bernlöhr, H. Yoneda, Paolo Marchegiani, M. Tluczykont, D. J. van der Walt, A. Djannati-Ataï, Francois Brun, P. Vincent, Markus Holler, Misao Sasaki, Felix Jankowsky, Jacek Niemiec, V. Marandon, C. Trichard, H. Odaka, Felix Aharonian, Olaf Reimer, S. Bonnefoy, Constantin Steppa, Garret Cotter, Celine Armand, Michael Backes, E. Ruiz-Velasco, Thomas Bylund, D. Huber, M.-H. Grondin, Tim Holch, E. Leser, Thomas Murach, Joachim Hahn, J. Muller, G. Hermann, Regis Terrier, D. A. Prokhorov, K. Kosack, C. Levy, Ullrich Schwanke, Naomi Tsuji, Carlo Romoli, Angel Noel, Jonathan Mackey, D. Berge, Gerard Fontaine, B. Peyaud, Iryna Lypova, S. Chandra, L. Giunti, M. Katsuragawa, Yvonne Becherini, C. Moore, Dorit Glawion, K. Egberts, E. Moulin, A. Reimer, Tomasz Bulik, Halim Ashkar, Andreas Quirrenbach, M. Böttcher, Paul J. Morris, Kleopas Shiningayamwe, P. T. O'Brien, Lenka Tomankova, C. van Eldik, L. Dirson, J. F. Glicenstein, Tom Armstrong, Matteo Cerruti, H. Ndiyavala, B. van Soelen, B. Rudak, F. Schüssler, Werner Hofmann, M. Büchele, S. J. Fegan, F. Niederwanger, Bruno Khelifi, Jacco Vink, Sabrina Casanova, M. Curyło, Rachel Simoni, Masanori Arakawa, M. Scalici, G. Martí-Devesa, H. Iwasaki, G. Vasileiadis, Włodek Kluźniak, Christoph Deil, Mohanraj Senniappan, G. Emery, S. Saito, Armelle Jardin-Blicq, K. Nakashima, Heinrich J. Völk, M. Renaud, A. Sinha, Christo Venter, A. Zech, A.M. Taylor, Andreas Specovius, Stefan Klepser, Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), Gravitation and Astroparticle Physics Amsterdam, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), H.E.S.S., German Research Foundation, Alexander von Humboldt Foundation, Centre National de la Recherche Scientifique (France), Japan Society for the Promotion of Science, Science and Technology Facilities Council (UK), Fundación 'la Caixa', National Aeronautics and Space Administration (US), H.E.S.S. Collaboration, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, Michael, 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 30366755 - Chand, Tej B., 31125417 - Chandra, Sunil, 33379009 - Kreter, Michael, 26403366 - Ndiyavala, Hambeleleni, 22799133 - Schutte, Hester M., 20126999 - Seyffert, Albertus Stefanus, 10060499 - Van der Walt, Diederick Johannes, 21106266 - Van Rensburg, Carlo, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 29092086 - Zacharias, Michael, and 34208968 - Zywucka-Hejzner, Natalia

Subjects
individual [BL Lacertae objects], Swift Gamma-Ray Burst Mission, VHE [gamma ray], satellite, Resolved and unresolved sources as a function of wavelength, Astrophysics, 01 natural sciences, GLAST, blazar, high-redshift [Galaxies], galaxies: high-redshift, 5/3, HESS, 0103 physical sciences, Atom, High Energy Stereoscopic System, Spectroscopy, Blazar, 010303 astronomy & astrophysics, BL Lacertae objects: individual, Astroparticle physics, Physics, general [Gamma-rays], energy: high, 010308 nuclear & particles physics, Astronomy and Astrophysics, gamma-rays: general, redshift, Redshift, gamma ray: VHE, 13. Climate action, Space and Planetary Science, ddc:520, high [energy], HESS - Abteilung Hinton, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope
Abstract

H.E.S.S. Collaboration: et al., We report on the detection of very high energy (VHE; E > 100 GeV) γ-ray emission from the BL Lac objects KUV 00311−1938 and PKS 1440−389 with the High Energy Stereoscopic System (H.E.S.S.). H.E.S.S. observations were accompanied or preceded by multiwavelength observations with Fermi/LAT, XRT and UVOT onboard the Swift satellite, and ATOM. Based on an extrapolation of the Fermi/LAT spectrum towards the VHE γ-ray regime, we deduce a 95 per cent confidence level upper limit on the unknown redshift of KUV 00311−1938 of z < 0.98 and of PKS 1440−389 of z < 0.53. When combined with previous spectroscopy results, the redshift of KUV 00311−1938 is constrained to 0.51 ≤ z < 0.98 and of PKS 1440−389 to 0.14 ⪅ z < 0.53., The support of the Namibian authorities and of the University of Namibia in facilitating the construction and operation of H.E.S.S. is gratefully acknowledged, as is the support by the German Ministry for Education and Research (BMBF), the Max Planck Society, the German Research Foundation (DFG), the Helmholtz Association, the Alexander von Humboldt Foundation, the French Ministry of Higher Education, Research and Innovation, the Centre National de la Recherche Scientifique (CNRS/IN2P3 and CNRS/INSU), the Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA), the U.K. Science and Technology Facilities Council (STFC), the Knut and Alice Wallenberg Foundation, the National Science Centre, Poland grant no. 2016/22/M/ST9/00382, the South African Department of Science and Technology and National Research Foundation, the University of Namibia, the National Commission on Research, Science and Technology of Namibia (NCRST), the Austrian Federal Ministry of Education, Science and Research and the Austrian Science Fund (FWF), the Australian Research Council (ARC), the Japan Society for the Promotion of Science, and the University of Amsterdam. We appreciate the excellent work of the technical support staff in Berlin, Zeuthen, Heidelberg, Palaiseau, Paris, Saclay, Tubingen, and in Namibia in the construction and operation of the equipment. This work benefited from services provided by the H.E.S.S. Virtual Organisation, supported by the national resource providers of the EGI Federation. The H.E.S.S. and Fermi/LAT analysis computations were performed on resources provided by the Swedish National Infrastructure for Computing (SNIC) at Lunarc. Tomas Bylund and Yvonne Becherini wish to acknowledge the support of the Data Intensive Sciences and Applications (DISA) centre at Linnaeus University. Matteo Cerruti has received financial support through the Postdoctoral Junior Leader Fellowship Programme from “la Caixa” Foundation (LCF/BQ/PI18/11630012). This research made use of the NASA/IPAC Extragalactic Database (NED) and of the SIMBAD Astronomical Database, of data products from the Wide-field Infrared Survey Explorer, which is a joint project of the University of California, Los Angeles, and the Jet Propulsion Laboratory/California Institute of Technology, funded by the National Aeronautics and Space Administration. We acknowledge the use of public data from the Swift data archive. This research made use of Gammapy, a community- developed core Python package for gamma-ray astronomy (Deil et al. 2017). This research has made use of data and software provided by the Fermi Science Support Center, managed by the HEASARC at the Goddard Space Flight Center. Part of this work is based on archival data, software or online services provided by the Space Science Data Center - ASI. This research has made use of the VizieR catalogue access tool, CDS, Strasbourg, France (doi:10.26093/cds/vizier). The original description of the VizieR service was published in A&AS 143, 23. This research has made use of the NASA/IPAC Infrared Science Archive, which is funded by the National Aeronautics and Space Administration and operated by the California Institute of Technology.

Published
2020
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44. Multicenter Evaluation of the New Etest Gradient Diffusion Method for Piperacillin-Tazobactam Susceptibility Testing of Enterobacterales , Pseudomonas aeruginosa , and Acinetobacter baumannii Complex

Author

Meghan A. Wallace, Carey-Ann D. Burnham, Sergio García-Fernández, María García-Castillo, Rafael Cantón, Tom Armstrong, Gilles Zambardi, Yohann Bala, and Dwight J. Hardy

Subjects
0301 basic medicine, Microbiology (medical), Gradient Diffusion Method, biology, Klebsiella pneumoniae, Pseudomonas aeruginosa, business.industry, 030106 microbiology, Broth microdilution, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, biology.organism_classification, medicine.disease_cause, Microbiology, Acinetobacter baumannii, 03 medical and health sciences, 0302 clinical medicine, Enterobacterales, Piperacillin/tazobactam, medicine, 030212 general & internal medicine, business, Etest, medicine.drug
Abstract

Piperacillin-tazobactam (P/T) is a β-lactam-β-lactamase inhibitor combination frequently used in the hospital setting. Etest is a gradient diffusion method that represents an alternative to broth microdilution (BMD) for performing antimicrobial susceptibility testing. We conducted a multicenter evaluation of the performance of the new P/T Etest compared to that of BMD following U.S. Food and Drug Administration (FDA) and International Standards Organization (ISO) standard ISO 20776-2 criteria using Clinical and Laboratory Standards Institute (CLSI)-FDA and European Committee on Antimicrobial Susceptibility Testing (EUCAST) interpretive breakpoints, respectively. A total of 977 isolates (775 Enterobacterales isolates, 119 Pseudomonas aeruginosa isolates, and 83 Acinetobacter baumannii complex isolates) were tested. Overall essential agreement (EA) was 96.4% and 96.6% for Enterobacterales when FDA and ISO 20776-2 criteria, respectively, were followed. EA was 98.3% for P. aeruginosa and 91.6% for the A. baumannii complex when both the FDA and ISO criteria were followed. Applying CLSI-FDA breakpoints, categorical agreement (CA) reached 93.0%, 93.3%, and 89.2% for the Enterobacterales, P. aeruginosa, and the A. baumannii complex, respectively. Two very major errors (VMEs; 1.1%) were found among the Enterobacterales (for 2 Klebsiella pneumoniae isolates). No additional major errors (MEs) or VMEs were found. Applying EUCAST breakpoints, CA was 94.8% and 95.8% for Enterobacterales and P. aeruginosa, respectively (no breakpoints are currently available for the A. baumannii complex). No VMEs were observed among the Enterobacterales, but 2 (0.4%) MEs were found. Among the P. aeruginosa isolates, 2 (6.9%) VMEs and 3 (3.3%) MEs were observed. These errors resulted when P/T Etest MICs were 1 doubling dilution apart from the BMD MICs. In conclusion, the new P/T Etest represents an accurate tool for performing antimicrobial susceptibility testing of Enterobacterales, P. aeruginosa, and A. baumannii complex isolates with limited category errors.

Published
2020
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45. Detection of very-high-energy γ -ray emission from the colliding wind binary η Car with H.E.S.S

Author

E. O. Angüner, Ramin Marx, M. Panter, U. Katz, G. Heinzelmann, Iryna Lypova, S. Nakashima, Yvonne Becherini, G. Martí-Devesa, Stefan Klepser, H. Yoneda, A. Fiasson, L. Giunti, P. deWilt, J. King, R. Adam, I. Jung-Richardt, James Davies, F. Eichhorn, Michael Punch, Maria Haupt, R. J. Tuffs, Michal Ostrowski, J.-P. Lenain, Stefan Ohm, Łukasz Stawarz, J. F. Glicenstein, Frank M. Rieger, Markus Holler, Michelle Tsirou, C. Levy, S. Pita, S. Colafrancesco, L. Rinchiuso, Q. Remy, Felix Jankowsky, J. Zorn, M.-H. Grondin, Mischa Breuhaus, C. Arcaro, Stefano Gabici, F. Niederwanger, Jacco Vink, Sabrina Casanova, Halim Ashkar, M. Curyło, Stefan Funk, Alicja Wierzcholska, Gavin Rowell, M. Bryan, Felix Aharonian, N. Shafi, R. D. Parsons, H. Ndiyavala, B. van Soelen, B. Rudak, Dmitriy Kostunin, K. Nakashima, Nu. Komin, Natalia Żywucka, M. de Naurois, T. Chand, Jhilik Majumdar, L. Oakes, A. Lemière, Heinrich J. Völk, M. Renaud, R. Rauth, Axel Donath, A. W. Chen, M. Büchele, S. Eschbach, M. Barnard, Marek Jamrozy, J. Bolmont, Gianluca Giavitto, K. Bernlöhr, Helene Sol, V. Poireau, H. Odaka, M. Füßling, Jacek Niemiec, Rafal Moderski, C. Perennes, K. Egberts, Dieter Horns, Olaf Reimer, M. Lemoine-Goumard, J. Dyks, Ruizhi Yang, Francois Brun, Reinhard Schlickeiser, Zorawar Wadiasingh, M. Böttcher, Michael Kreter, S. Chandra, Paolo Marchegiani, P. Vincent, S. J. Fegan, A. Djannati-Ataï, V. Barbosa Martins, S. Raab, L. Dirson, F. Gaté, Kirsty Feijen, S. Bonnefoy, Constantin Steppa, Alexandre Marcowith, M. Zacharias, Rachel Simoni, Masanori Arakawa, Celine Armand, Thomas Murach, Joachim Hahn, T. Vuillaume, A. Schulz, Clemens Hoischen, A. A. Zdziarski, Ullrich Schwanke, V. Joshi, V. Sahakian, A. Carosi, F. Werner, F. Ait Benkhali, E. de Oña Wilhelmi, Anton Dmytriiev, Isak Delberth Davids, S. Schwemmer, Arnaud Mares, Andrea Santangelo, Jim Hinton, Roberta Zanin, C. Trichard, S. Sailer, Dmitry Khangulyan, P. J. Meintjes, Tom Armstrong, Matteo Cerruti, D. A. Sanchez, M. Seglar-Arroyo, P.-O. Petrucci, Johan Bregeon, R. J. White, J. Devin, F. Schüssler, M. Scalici, A. Priyana Noel, Domenico Tiziani, D. Malyshev, Tadayuki Takahashi, A.M. Taylor, Werner Hofmann, Michael Backes, Jonathan Mackey, Victor Doroshenko, Gilles Henri, Heike Prokoph, C. Moore, Q. Piel, Dorit Glawion, Tim Holch, E. Moulin, Tomasz Bulik, S. Caroff, D. Huber, Marion Spir-Jacob, G. Maurin, H. Iwasaki, A.S. Seyffert, Naomi Tsuji, D. Jankowsky, Gerard Fontaine, M. Katsuragawa, Andreas Quirrenbach, Hester Schutte, Riaan Steenkamp, Andreas Specovius, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, L. Mohrmann, C. van Rensburg, Misao Sasaki, D. J. van der Walt, M. Hörbe, T. Tavernier, E. Leser, P. T. O'Brien, B. Khélifi, G. Hermann, Regis Terrier, Carlo Romoli, Christo Venter, Y. A. Gallant, Atreyee Sinha, C. van Eldik, A. Zech, M. Mohamed, Garret Cotter, D. A. Prokhorov, K. Kosack, B. Peyaud, G. Pühlhofer, A. Reimer, Pierre Brun, Jean-Pierre Ernenwein, Johannes Veh, R. Blackwell, E. Ruiz-Velasco, G. Emery, S. Saito, Thomas Bylund, M. Tluczykont, Armelle Jardin-Blicq, Jacques Muller, Samuel Timothy Spencer, H. Abdalla, M. A. Kastendieck, G. Vasileiadis, Włodek Kluźniak, Krzysztof Katarzynski, Catherine Boisson, Christoph Deil, Mohanraj Senniappan, D. Berge, Paul J. Morris, Kleopas Shiningayamwe, Lenka Tomankova, Jason John Watson, V. Marandon, D. Gottschall, Thomas Lohse, G. Lamanna, Alexander von Humboldt Foundation, Southern California Earthquake Center, EGI Foundation, Science and Technology Facilities Council (UK), Australian Research Council, German Research Foundation, Japan Society for the Promotion of Science, University of Amsterdam, Federal Ministry of Education and Research (Germany), Austrian Science Fund, Knut and Alice Wallenberg Foundation, Max Planck Society, National Science Centre (Poland), Centre National de la Recherche Scientifique (France), Commissariat à l'Ènergie Atomique et aux Ènergies Alternatives (France), Helmholtz Association, National Commission on Research Science and Technology (Namibia), University of Namibia, Federal Ministry of Education, Science and Research (Austria), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), H.E.S.S., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, H.E.S.S. Collaboration, Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), Gravitation and Astroparticle Physics Amsterdam, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)

Subjects
individual: η CarStars: Wolf-Rayet [Stars], Photon, stars: individual: η Car, Astrophysics::High Energy Astrophysical Phenomena, Flux, Cosmic ray, Astrophysics, 01 natural sciences, cosmic rays, 0103 physical sciences, individual: η Car [stars], High Energy Stereoscopic System, 010303 astronomy & astrophysics, Cosmic rays, Colliding-wind binary, Astroparticle physics, Physics, Spectral index, non-thermal [Radiation mechanisms], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], general [Binaries], 010308 nuclear & particles physics, Astronomy and Astrophysics, radiation mechanisms: non-thermal, Wolf-Rayet [stars], binaries: general, 13. Climate action, Space and Planetary Science, [SDU]Sciences of the Universe [physics], astroparticle physics, ddc:520, HESS - Abteilung Hinton, stars: Wolf-Rayet, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Stars: individual: η CarStars: Wolf-Rayet, Noise (radio)
Abstract

Aims. Colliding wind binary systems have long been suspected to be high-energy (HE; 100 MeV < E < 100 GeV) {\gamma}-ray emitters. {\eta} Car is the most prominent member of this object class and is confirmed to emit phase-locked HE {\gamma} rays from hundreds of MeV to ~100 GeV energies. This work aims to search for and characterise the very-high-energy (VHE; E >100 GeV) {\gamma}-ray emission from {\eta} Car around the last periastron passage in 2014 with the ground-based High Energy Stereoscopic System (H.E.S.S.). Methods. The region around {\eta} Car was observed with H.E.S.S. between orbital phase p = 0.78 - 1.10, with a closer sampling at p {\approx} 0.95 and p {\approx} 1.10 (assuming a period of 2023 days). Optimised hardware settings as well as adjustments to the data reduction, reconstruction, and signal selection were needed to suppress and take into account the strong, extended, and inhomogeneous night sky background (NSB) in the {\eta} Car field of view. Tailored run-wise Monte-Carlo simulations (RWS) were required to accurately treat the additional noise from NSB photons in the instrument response functions. Results. H.E.S.S. detected VHE {\gamma}-ray emission from the direction of {\eta} Car shortly before and after the minimum in the X-ray light-curve close to periastron. Using the point spread function provided by RWS, the reconstructed signal is point-like and the spectrum is best described by a power law. The overall flux and spectral index in VHE {\gamma} rays agree within statistical and systematic errors before and after periastron. The {\gamma}-ray spectrum extends up to at least ~400 GeV. This implies a maximum magnetic field in a leptonic scenario in the emission region of 0.5 Gauss. No indication for phase-locked flux variations is detected in the H.E.S.S. data., Comment: 9 pages, 4 figures, 3 tables, in press with A&A

Published
2020
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46. Multicenter Evaluation of the New Etest Gradient Diffusion Method for Piperacillin-Tazobactam Susceptibility Testing of

Author

Sergio, García-Fernández, Yohann, Bala, Tom, Armstrong, María, García-Castillo, C A, Burnham, Meghan A, Wallace, Dwight, Hardy, Gilles, Zambardi, and Rafael, Cantón

Subjects
Acinetobacter baumannii, Internationality, United States Food and Drug Administration, Reproducibility of Results, bacterial infections and mycoses, United States, Anti-Bacterial Agents, Piperacillin, Tazobactam Drug Combination, Enterobacteriaceae, Disk Diffusion Antimicrobial Tests, Pseudomonas aeruginosa, polycyclic compounds, Commentary, bacteria, Humans, European Union
Abstract

In this issue of the Journal of Clinical Microbiology, S. García-Fernandez, Y. Bala, T. Armstrong, M. Garcia-Castillo, et al. (J Clin Microbiol 58:e01042-19, 2020, https://doi.org/10.1128/JCM.01042-19) describe the performance of a reformulated Etest for piperacillin-tazobactam. The analytical performance data are excellent, but in the face of recent emerging data on the inefficacy of piperacillin-tazobactam for certain organisms that test susceptible, the value of piperacillin-tazobactam MICs is controversial. Evaluation of MICs in the context of the modal MIC for Enterobacterales and Pseudomonas aeruginosa, the variability of MIC tests, and, possibly, resistance mechanisms is important to the optimum use of this antimicrobial.

Published
2019

48. 1227. Plazomicin Susceptibility Testing using ETEST® MIC for Enterobacterales

Author

Yun Ying, Gilles Zambardi, Laurine S Blanchard, Michael Kresken, Tom Armstrong, and Marion Pompilio

Subjects
medicine.medical_specialty, Susceptibility testing, business.industry, biochemical phenomena, metabolism, and nutrition, Plazomicin, chemistry.chemical_compound, Infectious Diseases, AcademicSubjects/MED00290, Oncology, chemistry, Internal medicine, Enterobacterales, Poster Abstracts, medicine, bacteria, business, Etest
Abstract

Background Plazomicin (PLZ) approved by FDA in June of 2018, is an aminoglycoside class antibacterial indicated for the treatment of adults with complicated urinary tract infections (cUTI) including pyelonephritis caused by Enterobacterales. It is used in patients who have limited or no alternative treatment options, e.g. CRE and MDRO patients. The drug has bactericidal activity, it is active against organisms producing ESBL, Carbapenemase and aminoglycoside-modifying enzymes. The purpose of this study was to compare ETEST® PLZ bioMérieux to the broth microdilution reference method (BMD) for Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca and pneumoniae, Morganella morganii, Providencia stuartii, Proteus mirabilis and vulgaris and Serratia marcescens isolates. Methods A total of 598 isolates were tested by ETEST® (PLZ) and BMD at four clinical trial sites. Isolates were subcultured on tryptic soy or Columbia agar plates supplemented with 5% sheep blood. Suspensions of the isolates were prepared in 0.85% saline, which were used to inoculate BMD and Mueller Hinton agar for ETEST®. Results were read after 16-20 hours incubation at 35°C +2°C in ambient air. QC organisms were tested with each run following CLSI QC guidelines. Results were analyzed using FDA breakpoints for PLZ (Susceptible 8 µg/mL). Performance was evaluated using FDA performance criteria, EA and CA (≥ 90%), major error rate (≤3.0%) and very major error rate (≤2.0%). Results Conclusion ETEST® PLZ clinical performance met the FDA acceptance criteria and was found useful for determining Plazomicin MIC of Enterobacterales, including ESBL, CRE (MBL, KPC, Oxa-48), high level AmpC and aminoglycoside resistant strains. Percent susceptibility of Plazomicin is at 80% among the 598 isolates tested, the mode MIC is 0.5 ug/ml as Susceptible. Disclosures Tom Armstrong, BS, bioMérieux (Employee) Laurine Blanchard, PhD, bioMérieux (Employee) Michael Kresken, PhD, bioMérieux (Scientific Research Study Investigator, Research Grant or Support) Gilles Zambardi, biomerieux (Employee) Marion Pompilio, BioMérieux (Employee)

Published
2020

49. Combined Dark Matter searches towards dwarf spheroidal galaxies with Fermi-LAT, HAWC, HESS, MAGIC and VERITAS

Author

Dirk Lennarz, Luis Villaseñor, Gernot Maier, Anne Lemiere, Daniel Rosa-Gonzalez, Samuel Timothy Spencer, Wystan Benbow, Victor Barbosa Martins, Raul Prado, Arache Djannati-Ataï, Regis Terrier, Dan Parsons, Francisco Salesa Greus, Dmitriy Kostunin, Joshua Wood, Carlo Romoli, César Alvarez, Carlo van Rensburg, Massimo Capasso, Sajan Kumar, P. Reichherzer, Anton Dmytriiev, Stefan Ohm, Chiara Giuri, Brian van Soelen, G. Peron, Christian Stegmann, Emma Ona-Wilhelmi, S. J. Fegan, Alison Peisker, Hawc, Garret Cotter, Gary Gillanders, Zhiqiu Huang, Krzysztof Katarzynski, Filiberto Hueyotl-Zahuantitla, Ian Herzog, D. A. Prokhorov, K. Kosack, Halim Ashkar, Fabian Leuschner, Manami Sasaki, Michael Schneider, Joe Lundeen, Markus Boettcher, Brian Humensky, Isak Delberth Davids, A. Fiasson, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, David Kieda, Michael DuVernois, Albert Seyffert, Gianluca Giavitto, Qi Feng, Andreas Specovius, Andrew James Smith, Catherine Boisson, L. Mohrmann, Roberta Zanin, Marek Jamrozy, Tomás Capistrán Rojas, K. Nakashima, Jamie Holder, Hao Zhou, Thomas Lohse, Mireia Nievas-Rosillo, Samuel Zouari, Ira Jung, Sebastian Panny, K. Bernloehr, Deivid Ribeiro, Andrea Santangelo, Kristi Engel, Josefa Becerra Gonzalez, Thomas Tavernier, Ke Fang, Rishi Babu, Yu Wun Wong, Gerd J. Kunde, Jean-Pierre Ernenwein, Henrike Fleischhack, P. T. O'Brien, Clemens Hoischen, A. A. Zdziarski, Kelly Malone, Helene Sol, Markus Holler, Manel Errando, Atreyee Sinha, Francois Brun, Heinrich J. Völk, Sumari Hattingh, Kirsten Tollefson, Johann van der Walt, Q. Remy, Felix Jankowsky, Samridha Kunwar, Johannes Veh, M. Fuessling, P. Vincent, Harm Schoorlemmer, Stefano Gabici, Miguel Mostafa, Tyler Williamson, Jacek Niemiec, Michal Ostrowski, J.-P. Lenain, Israel Martinez Castellanos, Felix Aharonian, Tadayuki Takahashi, Gerd Puehlhofer, Lei Sun, Jesús Martínez-Castro, Pooja Surajbali, Andrés Sandoval, Hugh Spackman, Takaaki Tanaka, Segev BenZvi, Alexandre Marcowith, Felix Werner, Olaf Reimer, Vincent Marandon, Alberto Carramiñana, S. Steinmassl, Mary Kertzman, Hannes Thiersen, Victor Doroshenko, Michael Backes, Hannah Jhee, G. Lamanna, Marcos Santander, Angel Noel, W. Jin, Gus Sinnis, B. Rudak, Alasdair E. Gent, Kathrin Egberts, Jonathan Mackey, Fernando Ureña-Mena, Paolo Marchegiani, Sonal Ramesh Patel, Laenita Lorraine Oberholzer, Tim Holch, Sami Caroff, Heiko Salzmann, E. Kasai, Alison Mitchell, Gregory Foote, Nukri Komin, Tom Armstrong, Michelle Hui, Ruo-Yu Shang, Binita Hona, Raquel Diaz Hernandez, Vardan Baghmanyan, Celine Armand, Alejandro Lara, David Berley, Hector Rueda Ricarte, Nissim Illich Fraija, Naomi Tsuji, Gaurang Yodh, Stefan Funk, Alicja Wierzcholska, Conor McGrath, Gerard Fontaine, C. Moore, Vikas Joshi, Dorit Glawion, T. Chand, M. U. Nisa, M.-H. Grondin, Arnaud Mares, David Sanchez, Ernesto Belmont-Moreno, Thomas Murach, Eucario Gonzalo Pérez Pérez, Paul Reynolds, Ignacio Taboada, Xiaojie Wang, Lucy Fortson, Martin Tluczykont, Thomas Brian Humensky, Juan de Dios Álvarez Romero, Robert Ellsworth, Hester Schutte, Justine Devin, Constantin Steppa, Richard White, Rachel Simoni, Karen S. Caballero Mora, Elisa Pueschel, Jason Fan, Tomasz Bulik, Lukas Nellen, Malgorzata Curlo, Lente Dreyer, J. Patrick Harding, Gilles Maurin, Humberto Martínez Huerta, Riaan Steenkamp, Arnulfo Zepeda, Johannes Schaefer, Werner Hofmann, Jim Hinton, Michael Punch, S. Sailer, Dmitry Khangulyan, Sergio Hernández Cadena, Charles Thorpe-Morgan, M. Hörbe, Stephan O'Brien, Ramin Marx, John L. Quinn, J. F. Glicenstein, V. Sahakian, M. Panter, Mora Durocher, U. Katz, Jacco Vink, Umberto Cotti, Tobias Kleiner, Petra Hüntemeyer, David Huber, Ullrich Schwanke, Diego Garcia Aguilar, Vladimir Vassiliev, Oscar Martinez, J. Bolmont, Cederik León de León, Brian Fick, Laura Olivera-Nieto, A. Yusafzai, David Hanna, James Buckley, Lorenzo Diaz, Yves Gallant, Guillermo García-Torales, Arun Babu Kollamparambil, James Ryan, Kayla Farrell, Sabrina Casanova, Bruno Khelifi, María Catalina Espinoza Hernández, Jorge Antonio Morales Soto, Mateo Fernandez Alonso, Matthew Lundy, Faical Ait-Benkhali, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Jorge Luis Flores, Ibrahim Torres, Jordan A. Goodman, Anita Reimer, Adam Otte, Eduardo Moreno Barbosa, M. J. Lang, Frank M. Rieger, Elijah Willox, Colin Adams, Pedro Miranda-Romagnoli, Louis Du Plessis, Andrea Albert, Orel Gueta, Anna Barnacka, Brenda Dingus, Gašper Kukec Mezek, Hazal Goksu, Jorge Cotzomi, William H. Lee, Ruben Alfaro, Glenn Sembroski, David A. Williams, Eduardo de la Fuente, Anu Kundu, Dezhi Huang, Brian Reville, Connor Duffy, Edna Ruiz-Velasco, Anna Luashvili, Alisha Chromey, Konstantin Pfrang, L. Giunti, Philip Kaaret, Maria Magdalena González, Olivier Hervet, Hermes Leon Vargas, Sébastien Le Stum, Amanda Weinstein, Aryeh Brill, James Davies, Ken Ragan, Santiago Pita, Juan Carlos Arteaga Velazquez, Jason Lee, Sabrina Einecke, Lukasz Stawarz, Iryna Lypova, Julie McEnery, Sara Coutiño de Leon, Dieter Horns, R. J. Tuffs, Christo Venter, Meghan Tanner, Monica Barnard, B. Bi, Yvonne Becherini, Colas Rivière, Iftach Sadeh, Lott Frans, Mischa Breuhaus, Pauline Chambery, C. Levy, Jose Luis García-Luna, Michelle Tsirou, D. Malyshev, Ramiro Torres Escobedo, Hassan Abdalla, Hambeleleni Ndiyavala, Chang Dong Rho, Jhilik Majumdar, Martin Pohl, Mathieu Bony, Oguzhan Anguener, Hend Yassin, Gwenael Giacinti, Manuel Meyer, Arturo Iriarte, John Matthews, Kirsty Feijen, Ahron S. Barber, Floriane Cangemi, Fernando Garfias, R. A. Ong, Thomas Weisgarber, Thomas Bylund, Gilgamesh Luis-Raya, Rowan Batzofin, Mathieu Naurois, Jacques Muller, Avery Archer, Andreas Quirrenbach, Anushka Udara Abeysekara, José Serna-Franco, Hugo Alberto Ayala Solares, Davit Zargaryan, Rubén López-Coto, Reshmi Mukherjee, Andreas Zmija, Guillem Marti'i-Devesa, Sameer Patel, M. Lemoine-Goumard, Roberto Noriega-Papaqui, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Michael Kreter, Yunior Pérez Araujo, Anna Lia Longinotti, Michael Zacharias, Kleopas Shiningayamwe, Robert Brose, Fabian Schüssler, Emmanuel Moulin, Patrick Moriarty, Edna Ruiz Velasco, Michael Newbold, Oscar Chaparro-Amaro, J. T. Linnemann, Lenka Tomankova, Jodi Christiansen, Jaqueline Catalano, Ian James Watson, R. Konno, Andrew Taylor, C. Arcaro, Jason John Watson, Gavin Rowell, Daniel Omar Avila Rojas, Denys Malyshev, Emmet Roache, Rhiannon Turner, Chad Brisbois, Mohanraj Senniappan, José Roberto Angeles Camacho, Daniel Nieto, V. Poireau, Jimmy N.S. Shapopi, G. Vasileiadis, Hannah Dalgleish, donggeun tak, Juan Carlos Díaz Vélez, Armelle Jardin-Blicq, N. Zywucka, Abe Falcone, Nicola Omodei, Matthieu Renaud, German Hermann, Paul Morris, Maria Haupt, Stefan Klepser, Christopher van Eldik, Rafal Moderski, Alessandro Montanari, Amy Furniss, Sylvia Zhu, P. J. Meintjes, David Berge, Jose Andres Garcia-Gonzalez, Humberto Ibarguen Salazar, Wayne Robert Springer, Heike Prokoph, Marion Spir-Jacob, Amid Nayerhoda, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire d'Annecy de Physique des Particules (LAPP), Fermi-LAT, HAWC, H.E.S.S., MAGIC, and VERITAS

Subjects
Cherenkov detector, air, Cherenkov counter: water, Physics beyond the Standard Model, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, satellite, FOS: Physical sciences, IACT, Astrophysics, 01 natural sciences, GLAST, dark matter, law.invention, law, HESS, 0103 physical sciences, 010306 general physics, Cherenkov radiation, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Annihilation, 010308 nuclear & particles physics, background, new physics, imaging, sensitivity, MAGIC, Galaxy, Automatic Keywords, annihilation, VERITAS, galaxy, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], statistical, HAWC, Fermi Gamma-ray Space Telescope
Abstract

36th International Cosmic Ray Conference, ICRC2019, Madison, USA, 24 Jul 2019 - 1 Aug 2019; 9 pages (2019)., The search for Dark Matter (DM) has great potential to reveal physics beyond the Standard Model. As such, searches for evidence of DM particles are being carried out using a wide range of techniques, such as direct searches for DM particles, searches for DM produced with colliders, and indirect searches for the Standard Model annihilation products of DM. Dwarf spheroidal galaxies (dSphs) are excellent targets for indirect Dark Matter searches due to their relatively high DM content and negligible expected astrophysical background. A collaboration was formed to maximise the sensitivity of DM searches towards dSphs by combining for the first time dSph data from three imaging air Cherenkov telescope (IACT) arrays: HESS, MAGIC, and VERITAS; the Fermi-LAT satellite, and the water Cherenkov detector HAWC. Due to the diverse nature of the instruments involved, each experiment will analyse their individual datasets from multiple targets and then the results will be combined at the likelihood level. For consistency of the likelihoods across the five experiments, a common approach is used to treat the astrophysical factor (J-Factor) for each target and an agreed set of annihilation channels are considered. We also agree on a common statistical approach and treatment of instrumental systematic uncertainties. The results are presented in terms of constraints on the velocity-weighted cross section for DM self-annihilation as a function of the DM particle mass.

Published
2019
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50. Multicenter Evaluation of the Etest Gradient Diffusion Method for Ceftolozane-Tazobactam Susceptibility Testing of Enterobacteriaceae and Pseudomonas aeruginosa

Author

Hari-Prakash Dwivedi, Shelley Campeau, Janet F. Hindler, Romney M. Humphries, Carey-Ann D. Burnham, Maria M. Traczewski, Gerald A. Denys, Tom Armstrong, and Adam L. Bailey

Subjects
0301 basic medicine, Microbiology (medical), Tazobactam, medicine.drug_class, Klebsiella pneumoniae, 030106 microbiology, Antibiotics, medicine.disease_cause, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Enterobacteriaceae, Disk Diffusion Antimicrobial Tests, Drug Resistance, Multiple, Bacterial, medicine, Humans, Pseudomonas Infections, 030212 general & internal medicine, Etest, biology, Pseudomonas aeruginosa, Broth microdilution, Enterobacteriaceae Infections, Reproducibility of Results, Providencia rettgeri, Bacteriology, biology.organism_classification, bacterial infections and mycoses, Anti-Bacterial Agents, Cephalosporins, Metronidazole, medicine.drug
Abstract

Ceftolozane-tazobactam (C/T) is a novel beta-lactam-beta-lactamase inhibitor combination antibiotic approved by the U.S. Food and Drug Administration in 2014 for the treatment of complicated intra-abdominal infections (in combination with metronidazole) and complicated urinary tract infections. In this study, we evaluated the performance of the C/T Etest, a gradient diffusion method. C/T Etest was compared to broth microdilution (BMD) for 51 Enterobacteriaceae challenge isolates and 39 Pseudomonas aeruginosa challenge isolates at three clinical sites. Essential agreement (EA) between the methods ranged from 47 to 49/51 (92.2 to 96.1%) for the Enterobacteriaceae, and categorical agreement (CA) ranged from 49 to 51/51 (96.1 to 100.0%). EA and CA for P. aeruginosa were 100% at all sites. The C/T Etest was also compared to BMD for susceptibility testing on 966 clinical isolates (793 Enterobacteriaceae, including 167 Klebsiella pneumoniae and 159 Escherichia coli isolates, in addition to 173 P. aeruginosa isolates) collected at four clinical sites. EA between Etest and BMD was 96.9% for Enterobacteriaceae isolates and 98.8% for P. aeruginosa isolates. Within the Enterobacteriaceae, isolates from each species examined had >96% CA. For the clinical isolates, no very major errors were identified but two major errors were found (one for K. pneumoniae and one for Providencia rettgeri). By BMD, 47.0% of Enterobacteriaceae and 46.2% of P. aeruginosa challenge strains were nonsusceptible to C/T by CLSI breakpoint criteria; 8.2% of clinical Enterobacteriaceae isolates and 12.1% of clinical P. aeruginosa isolates were nonsusceptible to C/T by CLSI breakpoint criteria. In conclusion, Etest is accurate and reproducible for C/T susceptibility testing of Enterobacteriaceae and P. aeruginosa.

Published
2018

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