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168 results on '"Tomasi, Giampaolo"'

1. Supplementary Tables 1-4 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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2. Supplementary Figure 4 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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3. Supplementary Figure 6 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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4. Supplementary Figure 1 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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6. Supplementary Figure 2 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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7. Supplementary Figure 3 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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8. Supplementary Figure 5 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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9. Supplementary Figure Legends 1-7 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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10. Supplementary Methods, Figures 1-7, Table 1 from Evaluation of Deuterated 18F- and 11C-Labeled Choline Analogs for Cancer Detection by Positron Emission Tomography

Author

Witney, Timothy H., primary, Alam, Israt S., primary, Turton, David R., primary, Smith, Graham, primary, Carroll, Laurence, primary, Brickute, Diana, primary, Twyman, Frazer J., primary, Nguyen, Quang-Dé, primary, Tomasi, Giampaolo, primary, Awais, Ramla O., primary, and Aboagye, Eric O., primary

Published
2023
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11. Supplementary Figure 7 from Use of [11C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression

Author

Contractor, Kaiyumars, primary, Challapalli, Amarnath, primary, Barwick, Tara, primary, Winkler, Mathias, primary, Hellawell, Giles, primary, Hazell, Steve, primary, Tomasi, Giampaolo, primary, Al-Nahhas, Adil, primary, Mapelli, Paola, primary, Kenny, Laura M., primary, Tadrous, Paul, primary, Coombes, R. Charles, primary, Aboagye, Eric O., primary, and Mangar, Stephen, primary

Published
2023
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19. Evaluation of the agonist PET radioligand [11C]GR103545 to image kappa opioid receptor in humans: Kinetic model selection, test–retest reproducibility and receptor occupancy by the antagonist PF-04455242

Author

Naganawa, Mika, Jacobsen, Leslie K., Zheng, Ming-Qiang, Lin, Shu-Fei, Banerjee, Anindita, Byon, Wonkyung, Weinzimmer, David, Tomasi, Giampaolo, Nabulsi, Nabeel, Grimwood, Sarah, Badura, Lori L., Carson, Richard E., McCarthy, Timothy J., and Huang, Yiyun

Published
2014
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34. The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth

Author

Trousil, Sebastian, Kaliszczak, Maciej, Schug, Zachary, Nguyen, Quang-De, Tomasi, Giampaolo, Favicchio, Rosy, Brickute, Diana, Fortt, Robin, Twyman, Frazer J., Carroll, Laurence, Kalusa, Andrew, Navaratnam, Naveenan, Adejumo, Thomas, Carling, David, Gottlieb, Eyal, Aboagye, Eric O., and Cancer Research UK

Subjects
Science & Technology, positron emission tomography, choline kinase, MALIGNANT-TRANSFORMATION, PROLIFERATION, Cell Biology, MAGNETIC-RESONANCE-SPECTROSCOPY, MAMMARY EPITHELIAL-CELLS, PROSTATE-CANCER, ALPHA, PHOSPHOLIPID-METABOLISM, POSITRON-EMISSION-TOMOGRAPHY, Oncology, mitochondrial function, PHOSPHATIDYLCHOLINE, cancer, BREAST-CANCER, Life Sciences & Biomedicine, metabolism
Abstract

The glycerophospholipid phosphatidylcholine is the most abundant phospholipid species of eukaryotic membranes and essential for structural integrity and signaling function of cell membranes required for cancer cell growth. Inhibition of choline kinase alpha (CHKA), the first committed step to phosphatidylcholine synthesis, by the selective small-molecule ICL-CCIC-0019, potently suppressed growth of a panel of 60 cancer cell lines with median GI50 of 1.12 μM and inhibited tumor xenograft growth in mice. ICL-CCIC-0019 decreased phosphocholine levels and the fraction of labeled choline in lipids, and induced G1 arrest, endoplasmic reticulum stress and apoptosis. Changes in phosphocholine cellular levels following treatment could be detected non-invasively in tumor xenografts by [18F]-fluoromethyl-[1,2–2H4]-choline positron emission tomography. Herein, we reveal a previously unappreciated effect of choline metabolism on mitochondria function. Comparative metabolomics demonstrated that phosphatidylcholine pathway inhibition leads to a metabolically stressed phenotype analogous to mitochondria toxin treatment but without reactive oxygen species activation. Drug treatment decreased mitochondria function with associated reduction of citrate synthase expression and AMPK activation. Glucose and acetate uptake were increased in an attempt to overcome the metabolic stress. This study indicates that choline pathway pharmacological inhibition critically affects the metabolic function of the cell beyond reduced synthesis of phospholipids.

Published
2016

35. Substitution of venous for arterial blood sampling in the determination of regional rates of cerebral protein synthesis with L-[1- 11 C]leucine PET: A validation study.

Author

Tomasi, Giampaolo, Veronese, Mattia, Bertoldo, Alessandra, Smith, Carolyn B, and Schmidt, Kathleen C

Abstract

We developed and validated a method to estimate input functions for determination of regional rates of cerebral protein synthesis (rCPS) with L-[1-11C]leucine PET without arterial sampling. The method is based on a population-derived input function (PDIF) approach, with venous samples for calibration. Population input functions were constructed from arterial blood data measured in 25 healthy 18–24-year-old males who underwent L-[1-11C]leucine PET scans while awake. To validate the approach, three additional groups of 18–27-year-old males underwent L-[1-11C]leucine PET scans with both arterial and venous blood sampling: 13 awake healthy volunteers, 10 sedated healthy volunteers, and 5 sedated subjects with fragile X syndrome. Rate constants of the L-[1-11C]leucine kinetic model were estimated voxel-wise with measured arterial input functions and with venous-calibrated PDIFs. Venous plasma leucine measurements were used with venous-calibrated PDIFs for rCPS computation. rCPS determined with PDIFs calibrated with 30–60 min venous samples had small errors (RMSE: 4–9%), and no statistically significant differences were found in any group when compared to rCPS determined with arterial input functions. We conclude that in young adult males, PDIFs calibrated with 30–60 min venous samples can be used in place of arterial input functions for determination of rCPS with L-[1-11C]leucine PET. [ABSTRACT FROM AUTHOR]

Published
2019
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36. Abstract C118: Choline kinase inhibition with the novel pharmacological inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth

Author

Trousil, Sebastian, primary, Kalisczcak, Maciej, additional, Schug, Zachary, additional, Nguyen, Quang-De, additional, Tomasi, Giampaolo, additional, Favicchio, Rosy, additional, Brickute, Diana, additional, Fortt, Robin, additional, Twyman, Frazer J., additional, Carroll, Laurence, additional, Kalusa, Andrew, additional, Navaratnam, Naveenan, additional, Adejumo, Thomas, additional, Carling, David, additional, Gottlieb, Eyal, additional, and Aboagye, Eric O., additional

Published
2015
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37. Effects of shortened scanning intervals on calculated regional rates of cerebral protein synthesis determined with the L-[1-11C]leucine PET method.

Author

Tomasi, Giampaolo, Veronese, Mattia, Bertoldo, Alessandra, Beebe Smith, Carolyn, and Schmidt, Kathleen C.

Subjects
*PROTEIN synthesis, *LEUCINE, *PROPOFOL, *FRAGILE X syndrome, *POSITRON emission tomography, *THERAPEUTICS
Abstract

To examine effects of scan duration on estimates of regional rates of cerebral protein synthesis (rCPS), we reanalyzed data from thirty-nine previously reported L-[1-11C]leucine PET studies. Subjects consisted of 12 healthy volunteers studied twice, awake and under propofol sedation, and 15 subjects with fragile X syndrome (FXS) studied once under propofol sedation. All scans were acquired on a high resolution scanner. We used a basis function method for voxelwise estimation of parameters of the kinetic model of L-[1-11C]leucine and rCPS over the interval beginning at the time of tracer injection and ending 30, 45, 60, 75 or 90 min later. For each study and scan interval, regional estimates in nine regions and whole brain were obtained by averaging voxelwise estimates over all voxels in the region. In all three groups rCPS was only slightly affected by scan interval length and was very stable between 60 and 90 min. Furthermore, statistical comparisons of rCPS between awake and sedated healthy volunteers provided almost identical results when they were based on 60 min scan data as when they were based on data from the full 90 min interval. Statistical comparisons between sedated healthy volunteers and sedated subjects with FXS also yielded almost identical results when based on 60 and 90 min scan intervals. We conclude that, under the conditions of our studies, scan duration can be shortened to 60 min without loss of precision. [ABSTRACT FROM AUTHOR]

Published
2018
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38. Comparative assessment of segmentation algorithms for tumor delineation on a test retest (11)C choline dataset

Author

TOMASI, Giampaolo, SHEPHERD, Tony, TURKHEIMER, Federico E., VISVIKIS, Dimitris, ABOAGYE, Eric O., Comprehensive Cancer Imaging Center, Imperial College London, Faculty of Medecine, Turku PET Centre, Turku University Hospital (TYKS), Department of Medecine, Imperial College London, Optimisation Continue des Actions Thérapeutiques par l'Intégration d'Informations Multimodales, and Université de Brest (UBO)-Télécom Bretagne-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Abstract

International audience; Many methods have been proposed for tumor segmentation from positron emission tomography images. Because of the increasingly important role that [(11)C]choline is playing in oncology and because no study has compared segmentation methods on this tracer, the authors assessed several segmentation algorithms on a [(11)C]choline test-retest dataset. METHODS: Fixed and adaptive threshold-based methods, fuzzy C-means (FCM), Canny's edge detection method, the watershed transform, and the fuzzy locally adaptive Bayesian algorithm (FLAB) were used. Test-retest [(11)C]choline scans of nine patients with breast cancer were considered and the percent test-retest variability %VAR(TEST-RETEST) of tumor volume (TV) was employed to assess the results. The same methods were then applied to two denoised datasets generated by applying either a Gaussian filter or the wavelet transform. RESULTS: The (semi)automated methods FCM, FLAB, and Canny emerged as the best ones in terms of TV reproducibility. For these methods, the %root mean square error %RMSE of %VAR(TEST-RETEST), defined as %RMSE= variance+mean(2), was in the range 10%-21.2%, depending on the dataset and algorithm. Threshold-based methods gave TV estimates which were extremely variable, particularly on the unsmoothed data; their performance improved on the denoised datasets, whereas smoothing did not have a remarkable impact on the (semi)automated methods. TV variability was comparable to that of SUV(MAX) and SUV(MEAN) (range 14.7%-21.9% for %RMSE of %VAR(TEST-RETEST), after the exclusion of one outlier, 40%-43% when the outlier was included. CONCLUSIONS: The TV variability obtained with the best methods was similar to the one reported for TV in previous [(18)F]FDG and [(18)F]FLT studies and to the one of SUV(MAX)/SUV(MEAN) on the authors' [(11)C]choline dataset. The good reproducibility of [(11)C]choline TV warrants further studies to test whether TV could predict early response to treatment and survival, as for [(18)F]FDG, to complement/substitute the use of SUV(MAX) and SUV(MEAN).

Published
2012

50. Synthesis and Evaluation of 11C-LY2795050 as a κ-Opioid Receptor Antagonist Radiotracer for PET Imaging

Author

Zheng, Ming-Qiang, primary, Nabulsi, Nabeel, additional, Kim, Su Jin, additional, Tomasi, Giampaolo, additional, Lin, Shu-fei, additional, Mitch, Charles, additional, Quimby, Steven, additional, Barth, Vanessa, additional, Rash, Karen, additional, Masters, John, additional, Navarro, Antonio, additional, Seest, Eric, additional, Morris, Evan D., additional, Carson, Richard E., additional, and Huang, Yiyun, additional

Published
2013
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