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1. Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Author

Christopher Whelan, Urho Kujala, Arto Lehisto, Katri Pylkäs, Jaakko Kaprio, Eija Laakkonen, Anna Podgornaia, Juha Paloneva, Markus Juonala, Jukka Koskela, Heikki Joensuu, Tuomo Meretoja, Jari Laukkanen, Mika Kähönen, Matti Pirinen, Priit Palta, Nina Mars, Marja-Riitta Taskinen, Joseph Maranville, Teemu Niiranen, Mari Kaunisto, Joni Turunen, Shabbeer Hassan, Christian Klose, Kaisa Tasanen, Katariina Hannula-Jouppi, Tiinamaija Tuomi, Mathias Gerl, Johanna Schleutker, Tomi Makela, Kari Pulkki, Teea Salmi, Joel Rämö, Aarno Palotie, Juha Sinisalo, Valtteri Julkunen, Lauri Aaltonen, Rubina Tabassum, Antti Palomäki, Teijo Kuopio, Timo Sipilä, Niina Matikainen, Michal Surma, Anu-Maria Loukola, Martti Färkkilä, Pietari Ripatti, Paola Bronson, Andrea Ganna, Javier Gracia-Tabuenca, Kimmo Savinainen, Hannele Laivuori, Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, Doctoral Programme in Population Health, Clinicum, Doctoral Programme in Clinical Research, HUS Internal Medicine and Rehabilitation, HUS Abdominal Center, University Management, Pregnancy and Genes, HUS Gynecology and Obstetrics, Medicum, Department of Mathematics and Statistics, Helsinki Institute for Information Technology, Centre of Excellence in Complex Disease Genetics, Statistical and population genetics, Biostatistics Helsinki, Doctoral Programme in Mathematics and Statistics, Research Programs Unit, Research Programme of Molecular Medicine, Aarno Palotie / Principal Investigator, Doctoral Programme Brain & Mind, Marja-Riitta Taskinen Research Group, Faculty Common Matters (Faculty of Social Sciences), Department of Public Health, Doctoral Programme in Social Sciences, Genetic Epidemiology, Jaakko Kaprio / Principal Investigator, Biosciences, Doctoral Programme in Biomedicine, Data Science Genetic Epidemiology Lab, Department of Food and Nutrition, Departments of Faculty of Veterinary Medicine, Quantitative Genetics, Faculty of Medicine, HUSLAB, Helsinki Institute of Life Science HiLIFE, Department of Biochemistry and Developmental Biology, Mäkelä Lab, Doctoral Programme in Integrative Life Science, Department of Pathology, Department of Oncology, Heikki Joensuu / Principal Investigator, HUS Comprehensive Cancer Center, Department of Medicine, HUS Heart and Lung Center, HUS Inflammation Center, Department of Medical and Clinical Genetics, Genome-Scale Biology (GSB) Research Program, Lauri Antti Aaltonen / Principal Investigator, Olli Mikael Carpen / Principal Investigator, Precision Cancer Pathology, Department of Neurosciences, HUS Neurocenter, Tiinamaija Tuomi Research Group, Department of Ophthalmology and Otorhinolaryngology, HUS Head and Neck Center, Korva-, nenä- ja kurkkutautien klinikka, Doctoral Programme in Clinical Veterinary Medicine, Department of Dermatology, Allergology and Venereology, HYKS erva, Päijät-Häme Welfare Consortium, and University of Helsinki

Subjects
0301 basic medicine, False discovery rate, Science, General Physics and Astronomy, Disease, 030204 cardiovascular system & hematology, Biology, Cardiovascular, Genome-wide association studies, Article, General Biochemistry, Genetics and Molecular Biology, Plasma, 03 medical and health sciences, 0302 clinical medicine, Genetics, Humans, FinnGen Project, lcsh:Science, Lipoprotein lipase, Multidisciplinary, Prevention, Human Genome, 1184 Genetics, developmental biology, physiology, Lipid metabolism, Cardiovascular genetics, General Chemistry, Heritability, Lipidome, Lipids, Phenotype, Genetic architecture, 3. Good health, Cardiovascular diseases, Heart Disease, 030104 developmental biology, Cardiovascular Diseases, Lipidomics, lcsh:Q, lipids (amino acids, peptides, and proteins), 3111 Biomedicine, Genome-Wide Association Study
Abstract

Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P, Cardiovascular diseases (CVD) are associated with plasma lipid levels. Here, Tabassum et al. perform genome-wide association studies for lipidomic profiles with 141 (non-standard) lipid species which highlights shared genetic loci with CVD and that traditional lipids have low genetic correlation with other lipids.

Published
2019
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3. Sleep apnoea is a risk factor for severe COVID-19

Author

Riitta Kaarteenaho, Nina Hautala, Athena Matakidou, Jaakko Kaprio, Ying Wu, Kai Kaarniranta, Peeter Karihtala, Kari Pulkki, Wei Zhou, Caroline Fox, Jussi Pihlajamäki, Apinya Lertratanakul, Juha Paloneva, Johannes Kettunen, Marita Kalaoja, Markus Perola, Veikko Salomaa, Hilkka Soininen, Mika Kähönen, Hao Chen, Andrey Loboda, Soumitra Ghosh, Anders Mälarstig, Markku Laakso, Marja Luodonpää, Markus Juonala, Xing Chen, Marika Crohns, Juhani Junttila, Sirkku Peltonen, Keith Usiskin, Juha Sinisalo, Aarno Palotie, Samuli Ripatti, Oili Kaipiainen-Seppänen, Aki Havulinna, Satu Strausz, Tuomo Kiiskinen, Martin Broberg, Sanni Ruotsalainen, Jukka Koskela, Tuula Palotie, Hanna M. Ollila, Mark Daly, Howard Jacob, Heiko Runz, Sally John, Robert Plenge, Mark McCarthy, Julie Hunkapiller, Meg Ehm, Dawn Waterworth, Kathy Klinger, Kathy Call, Tomi Mäkelä, Petri Virolainen, Terhi Kilpi, Jukka Partanen, Anne Pitkäranta, Seppo Vainio, Kimmo Savinainen, Veli-Matti Kosma, Urho Kujala, Outi Tuovila, Minna Hendolin, Raimo Pakkanen, Jeff Waring, States Bridget Riley-Gillis, Jimmy Liu, Shameek Biswas, Dorothee Diogo, Anders Pfizer, Catherine Marshall, Matthias Gossel, Johanna Schleutker, Mikko Arvas, Olli Carpen, Reetta Hinttala, Reijo Laaksonen, Arto Mannermaa, Valtteri Julkunen, Anne Remes, Reetta Kälviäinen, Mikko Hiltunen, Jukka Peltola, Pentti Tienari, Juha Rinne, Adam Ziemann, Jeffrey Waring, Sahar Esmaeeli, Nizar Smaoui, Anne Lehtonen, Susan Eaton, Sanni Lahdenperä, John Michon, Geoff Kerchner, Natalie Bowers, Edmond Teng, John Merck, Vinay Mehta, Padhraig Gormley, Kari Linden, Christopher Whelan, Fanli Xu, David Pulford, Martti Färkkilä, Sampsa Pikkarainen, Airi Jussila, Timo Blomster, Mikko Kiviniemi, Markku Voutilainen, Bob Georgantas, Graham Heap, Fedik Rahimov, Joseph Maranville, Tim Lu, Danny Oh, Kirsi Kalpala, Melissa Miller, Linda McCarthy, Kari Eklund, Antti Palomäki, Pia Isomäki, Laura Pirilä, Johanna Huhtakangas, David Close, Marla Hochfeld, Nan Bing, Jorge Esparza Gordillo, Nina Mars, Tarja Laitinen, Margit Pelkonen, Paula Kauppi, Hannu Kankaanranta, Terttu Harju, Steven GreenbergCelgene, Hubert Chen, Jo Betts, Teemu Niiranen, Kaj Metsärinne, Marja-Riitta Taskinen, Tiinamaija Tuomi, Jari Laukkanen, Andrew Peterson Ben Challis, Audrey Chu, Jaakko Parkkinen, Anthony Muslin, Heikki Joensuu, Tuomo Meretoja, Lauri Aaltonen, Annika Auranen, Saila Kauppila, Päivi Auvinen, Klaus Elenius, Relja Popovic, Bridget Riley-Gillis, Jennifer Schutzman, Aparna Chhibber, Heli Lehtonen, Stefan McDonough, Diptee Kulkarni, Joni Turunen, Terhi Ollila, Sanna Seitsonen, Hannu Uusitalo, Vesa Aaltonen, Hannele Uusitalo-Järvinen, Erich Strauss, Anna Podgornaia, Joshua Hoffman, Kaisa Tasanen, Laura Huilaja, Katariina Hannula-Jouppi, Teea Salmi, Leena Koulu, Ilkka Harvima, David Choy, Anu Jalanko, Risto Kajanne, Ulrike Lyhs, Mari Kaunisto, Justin Davis, Danjuma Quarless, Slavé Petrovski, Chia-Yen Chen, Paola Bronson, Robert Yang, Diana Chang, Tushar Bhangale, Emily Holzinger, Xulong Wang, Åsa Hedman, Kirsi Auro, Clarence Wang, Ethan Xu, Franck Auge, Clement Chatelain, Mitja Kurki, Juha Karjalainen, Kimmo Palin, Priit Palta, Pietro Della, Susanna Lemmelä, Manuel Rivas, Jarmo Harju, Arto Lehisto, Andrea Ganna, Vincent Llorens, Antti Karlsson, Kati Kristiansson, Kati Hyvärinen, Jarmo Ritari, Tiina Wahlfors, Miika Koskinen, Katri Pylkäs, Minna Karjalainen, Tuomo Mantere, Eeva Kangasniemi, Sami Heikkinen, Eija Laakkonen, Juha Kononen, Anu Loukola, Päivi Laiho, Tuuli Sistonen, Essi Kaiharju, Markku Laukkanen, Elina Järvensivu, Sini Lähteenmäki, Lotta Männikkö, Regis Wong, Hannele Mattsson, Tero Hiekkalinna, Manuel Jiménez, Kati Donner, Kalle Pärn, Javier Nunez-Fontarnau, Elina Kilpeläinen, Timo Sipilä, Georg Brein, Alexander Dada, Ghazal Awaisa, Anastasia Shcherban, Tuomas Sipilä, Hannele Laivuori, Harri Siirtola, Javier Tabuenca, Lila Kallio, Sirpa Soini, Kimmo Pitkänen, and Teijo Kuopio

Subjects
Medicine, Diseases of the respiratory system, RC705-779
Abstract

Background Obstructive sleep apnoea (OSA) is associated with higher body mass index (BMI), diabetes, older age and male gender, which are all risk factors for severe COVID-19.We aimed to study if OSA is an independent risk factor for COVID-19 infection or for severe COVID-19.Methods OSA diagnosis and COVID-19 infection were extracted from the hospital discharge, causes of death and infectious diseases registries in individuals who participated in the FinnGen study (n=260 405). Severe COVID-19 was defined as COVID-19 requiring hospitalisation. Multivariate logistic regression model was used to examine association. Comorbidities for either COVID-19 or OSA were selected as covariates. We performed a meta-analysis with previous studies.Results We identified 445 individuals with COVID-19, and 38 (8.5%) of them with OSA of whom 19 out of 91 (20.9%) were hospitalised. OSA associated with COVID-19 hospitalisation independent from age, sex, BMI and comorbidities (p-unadjusted=5.13×10−5, OR-adjusted=2.93 (95% CI 1.02 to 8.39), p-adjusted=0.045). OSA was not associated with the risk of contracting COVID-19 (p=0.25). A meta-analysis of OSA and severe COVID-19 showed association across 15 835 COVID-19 positive controls, and n=1294 patients with OSA with severe COVID-19 (OR=2.37 (95% 1.14 to 4.95), p=0.021).Conclusion Risk for contracting COVID-19 was the same for patients with OSA and those without OSA. In contrast, among COVID-19 positive patients, OSA was associated with higher risk for hospitalisation. Our findings are in line with earlier works and suggest OSA as an independent risk factor for severe COVID-19.

Published
2021
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11. VISUAL MAPPING BY FIBER-FISH

Author

Heiskanen, M., Hellsten, E., Kallioniemi, O. P., tomi makela, Kari Alitalo, Leena Palotie, and Aarno Palotie

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