Search

Your search keyword '"Tomino, Carlo"' showing total 251 results
Start Over Author "Tomino, Carlo"
251 results on '"Tomino, Carlo"'

1. Assessing the Long-Term (48-Week) Effectiveness, Safety, and Tolerability of Fremanezumab in Migraine in Real Life: Insights from the Multicenter, Prospective, FRIEND3 Study

Author

Barbanti, Piero, Egeo, Gabriella, Proietti, Stefania, d’Onofrio, Florindo, Aurilia, Cinzia, Finocchi, Cinzia, Di Clemente, Laura, Zucco, Maurizio, Doretti, Alberto, Messina, Stefano, Autunno, Massimo, Ranieri, Angelo, Carnevale, Antonio, Colombo, Bruno, Filippi, Massimo, Tasillo, Miriam, Rinalduzzi, Steno, Querzani, Pietro, Sette, Giuliano, Forino, Lorenzo, Zoroddu, Francesco, Robotti, Micaela, Valenza, Alessandro, Camarda, Cecilia, Borrello, Laura, Aguggia, Marco, Viticchi, Giovanna, Tomino, Carlo, Fiorentini, Giulia, Orlando, Bianca, Bonassi, Stefano, and Torelli, Paola

Published
2024
Full Text
View/download PDF

2. Correction to: Assessing the Long-Term (48-Week) Effectiveness, Safety, and Tolerability of Fremanezumab in Migraine in Real Life: Insights from the Multicenter, Prospective, FRIEND3 Study

Author

Barbanti, Piero, Egeo, Gabriella, Proietti, Stefania, d’Onofrio, Florindo, Aurilia, Cinzia, Finocchi, Cinzia, Di Clemente, Laura, Zucco, Maurizio, Doretti, Alberto, Messina, Stefano, Autunno, Massimo, Ranieri, Angelo, Carnevale, Antonio, Colombo, Bruno, Filippi, Massimo, Tasillo, Miriam, Rinalduzzi, Steno, Querzani, Pietro, Sette, Giuliano, Forino, Lorenzo, Zoroddu, Francesco, Robotti, Micaela, Valenza, Alessandro, Camarda, Cecilia, Borrello, Laura, Aguggia, Marco, Viticchi, Giovanna, Tomino, Carlo, Fiorentini, Giulia, Orlando, Bianca, Bonassi, Stefano, and Torelli, Paola

Published
2024
Full Text
View/download PDF

4. Early and sustained efficacy of fremanezumab over 24-weeks in migraine patients with multiple preventive treatment failures: the multicenter, prospective, real-life FRIEND2 study

Author

Barbanti, Piero, Egeo, Gabriella, Aurilia, Cinzia, Torelli, Paola, Finocchi, Cinzia, d’Onofrio, Florindo, d’Onofrio, Luigi, Rao, Renata, Messina, Stefano, Di Clemente, Laura, Ranieri, Angelo, Autunno, Massimo, Sette, Giuliano, Colombo, Bruno, Carnevale, Antonio, Aguggia, Marco, Tasillo, Miriam, Zoroddu, Francesco, Frediani, Fabio, Filippi, Massimo, Tomino, Carlo, Proietti, Stefania, and Bonassi, Stefano

Published
2023
Full Text
View/download PDF

8. Exploring the Role of Bergamot Polyphenols in Alleviating Morphine-Induced Hyperalgesia and Tolerance through Modulation of Mitochondrial SIRT3.

Author

Ilari, Sara, Nucera, Saverio, Passacatini, Lucia Carmela, Scarano, Federica, Macrì, Roberta, Caminiti, Rosamaria, Ruga, Stefano, Serra, Maria, Giancotti, Luigino Antonio, Lauro, Filomena, Dagostino, Concetta, Mazza, Valeria, Ritorto, Giovanna, Oppedisano, Francesca, Maiuolo, Jessica, Palma, Ernesto, Malafoglia, Valentina, Tomino, Carlo, Mollace, Vincenzo, and Muscoli, Carolina

Abstract

Morphine is an important pain reliever employed in pain management, its extended utilize is hindered by the onset of analgesic tolerance and oxidative stress. Long-term morphine administration causes elevated production of reactive oxygen species (ROS), disrupting mitochondrial function and inducing oxidation. Sirtuin 3 (SIRT3), a mitochondrial protein, is essential in modulating ROS levels by regulating mitochondrial antioxidant enzymes as manganese superoxide dismutase (MnSOD). Our investigation focused on the impact of SIRT3 on hyperalgesia and morphine tolerance in mice, as evaluating the antioxidant effect of the polyphenolic fraction of bergamot (BPF). Mice were administered morphine twice daily for four consecutive days (20 mg/kg). On the fifth day, mice received an acute dose of morphine (3 mg/kg), either alone or in conjunction with BPF or Mn (III)tetrakis (4-benzoic acid) porphyrin (MnTBAP). We evaluated levels of malondialdehyde (MDA), nitration, and the activity of SIRT3, MnSOD, glutamine synthetase (GS), and glutamate 1 transporter (GLT1) in the spinal cord. Our findings demonstrate that administering repeated doses of morphine led to the development of antinociceptive tolerance in mice, accompanied by increased superoxide production, nitration, and inactivation of mitochondrial SIRT3, MnSOD, GS, and GLT1. The combined administration of morphine with either BPF or MnTBAP prevented these effects. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. New Therapeutics for Heart Failure Worsening: Focus on Vericiguat.

Author

Russo, Patrizia, Vitiello, Laura, Milani, Francesca, Volterrani, Maurizio, Rosano, Giuseppe M. C., Tomino, Carlo, and Bonassi, Stefano

Subjects
SECOND messengers (Biochemistry), NATRIURETIC peptides, ACE inhibitors, GUANYLATE cyclase, CARDIOVASCULAR system, HEART failure
Abstract

Heart failure (HF) is a syndrome characterized by signs and symptoms resulting from structural or functional cardiac abnormalities, confirmed by elevated natriuretic peptides or evidence of congestion. HF patients are classified according to left ventricular ejection fraction (LVEF). Worsening HF (WHF) is associated with increased short- and long-term mortality, re-hospitalization, and healthcare costs. The standard treatment of HF includes angiotensin-converting enzyme inhibitors, angiotensin receptor–neprilysin inhibitors, mineralocorticoid-receptor antagonists, beta-blockers, and sodium-glucose-co-transporter 2 inhibitors. To manage systolic HF by reducing mortality and hospitalizations in patients experiencing WHF, treatment with vericiguat, a direct stimulator of soluble guanylate cyclase (sGC), is indicated. This drug acts by stimulating sGC enzymes, part of the nitric oxide (NO)–sGC–cyclic guanosine monophosphate (cGMP) signaling pathway, regulating the cardiovascular system by catalyzing cGMP synthesis in response to NO. cGMP acts as a second messenger, triggering various cellular effects. Deficiencies in cGMP production, often due to low NO availability, are implicated in cardiovascular diseases. Vericiguat stimulates sGC directly, bypassing the need for a functional NO-sGC-cGMP axis, thus preventing myocardial and vascular dysfunction associated with decreased sGC activity in heart failure. Approved by the FDA in 2021, vericiguat administration should be considered, in addition to the four pillars of reduced EF (HFrEF) therapy, in symptomatic patients with LVEF < 45% following a worsening event. Cardiac rehabilitation represents an ideal setting where there is more time to implement therapy with vericiguat and incorporate a greater number of medications for the management of these patients. This review covers vericiguat's metabolism, molecular mechanisms, and drug–drug interactions. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. Inhibition of HECT E3 ligases as potential therapy for COVID-19

Author

Novelli, Giuseppe, Liu, Jing, Biancolella, Michela, Alonzi, Tonino, Novelli, Antonio, Patten, J. J., Cocciadiferro, Dario, Agolini, Emanuele, Colona, Vito Luigi, Rizzacasa, Barbara, Giannini, Rosalinda, Bigio, Benedetta, Goletti, Delia, Capobianchi, Maria Rosaria, Grelli, Sandro, Mann, Justin, McKee, Trevor D., Cheng, Ke, Amanat, Fatima, Krammer, Florian, Guarracino, Andrea, Pepe, Gerardo, Tomino, Carlo, Tandjaoui-Lambiotte, Yacine, Uzunhan, Yurdagul, Tubiana, Sarah, Ghosn, Jade, Notarangelo, Luigi D., Su, Helen C., Abel, Laurent, Cobat, Aurélie, Elhanan, Gai, Grzymski, Joseph J., Latini, Andrea, Sidhu, Sachdev S., Jain, Suresh, Davey, Robert A., Casanova, Jean-Laurent, Wei, Wenyi, and Pandolfi, Pier Paolo

Published
2021
Full Text
View/download PDF

16. Mitochondrial SIRT3 and morphine induced hyperalgesia and tolerance: the effect of polyphenol fraction of bergamot

Author

Ilari, Sara S., primary, Lauro, Filomena A., additional, Giancotti, Luigino, additional, Dagostino, Concetta, additional, Malafoglia, Valentina, additional, Passacatini, Lucia C., additional, Garofalo, Cinzia, additional, Tafani, Marco, additional, Palma, Ernesto, additional, Tomino, Carlo, additional, Salvemini, Daniela, additional, Mollace, Vincenzo, additional, and Muscoli, Carolina, additional

Published
2023
Full Text
View/download PDF

17. A Multicomponent Primary-Care Intervention for Preventing Falls in Older Adults Living in the Community: The PREMIO Study.

Author

Marrocco, Walter, Galli, Antonella, Scotti, Silvestro, Calabrese, Nicola, Misericordia, Paolo, Dalle Vedove, Alessandro, Marrocco, Gianmarco, D'Ingianna, Antonio Pio, Pizzini, Andrea, Fini, Massimo, Tomino, Carlo, and Bonassi, Stefano

Subjects
OLDER people, NUTRITION counseling, INDEPENDENT living, PREVENTION, BONE fractures, MEDICATION reconciliation
Abstract

Background: Falls are a common cause of morbidity and functional impairment in the elderly and represent a significant health problem. General practitioners (GPs) are the first point of contact for health issues and may provide preventive services. The randomized clinical trial PREMIO was conducted by GPs to evaluate the effects of a multicomponent intervention for the prevention of falls in older adults aged ≥ 65 years at high risk of falling. Methods: 117 GPs enrolled 1757 patients (1116 F, 641 M) and randomized them into 2 groups (intervention and control). The intervention group received medical and behavioral counseling, home risk-factor assessment, a physical-activity program and nutritional counseling. The control group received only the nutritional counseling. Both groups were followed for one year. The primary outcome was the rate of falls at home over 12 months. Results: 1225 patients completed the study. Subjects receiving the intervention had, on average, fewer falls at home (percentage change −31.2%, p < 0.02) and fewer total falls (−26.0%, p < 0.02), although the reduction in the number of fallers was small (−3.9%, p = 0.05). Among the secondary endpoints, rates of general hospital or emergency-department admission and GP visits showed slight improvements (not statistically significant), while the risk of fractures was unexpectedly increased in the intervention group compared to the controls (odds ratio 2.39, p = 0.023). Conclusions: Future studies and public-health interventions to prevent domestic falls among community-dwelling older people at high risk of falling could benefit from a multicomponent approach including medication review, physical exercise and home risk assessment and should include assessment of risk factors for fractures. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

18. An Observational Study on Chronic Pain Biomarkers in Fibromyalgia and Osteoarthritis Patients: Which Role for Mu Opioid Receptor’s Expression on NK Cells?

Author

Malafoglia, Valentina, primary, Ilari, Sara, additional, Gioia, Chiara, additional, Vitiello, Laura, additional, Tenti, Michael, additional, Iannuccelli, Cristina, additional, Cristiani, Costanza Maria, additional, Garofalo, Cinzia, additional, Passacatini, Lucia Carmela, additional, Viglietto, Giuseppe, additional, Scavalli, Antonio Sili, additional, Tomino, Carlo, additional, Mollace, Vincenzo, additional, Raffaeli, William, additional, Di Franco, Manuela, additional, and Muscoli, Carolina, additional

Published
2023
Full Text
View/download PDF

20. Budget Impact analysis of a new system of care in Parkinson’s disease patients

Author

Bini, Chiara, Mennini, Francesco Saverio, Marcellusi, Andrea, Paoletti, Martina, Tomino, Carlo, Bini, Chiara, Mennini, Francesco Saverio, Marcellusi, Andrea, Paoletti, Martina, and Tomino, Carlo

Abstract

Objective: To estimate the economic impact of the introduction of a new care system based on apomorphine and Patient Support Program for motor fluctuations (“on-off” phenomena) in patients with Parkinson’s disease which are not sufficiently controlled by oral anti-Parkinson medication in Italy. Method: A Budget Impact model was developed to evaluate the new care system in patients with Parkinson’s disease over a 3-years’ time horizon. The comparator treatments included in the analysis were treatments based on apomorphine and levodopa + carbidopa. The analysis was conducted from a National Health Service (NHS) perspective. Costs included in the analysis were acquisition costs and device costs. A deterministic sensitivity analysis was carried out to evaluate the uncertainty of the parameters used. A break-even analysis was conducted to identify the minimum number of subjects that would need to be treated with the new care system to obtain a positive Budget Impact (World With – World Without = 0). Results: The analysis shows that the introduction of the new care system based on apomorphine could generate a cost saving incurred by the NHS of over € 5.7 million in 3 years. Break-even analysis shows that if it were possible to intercept with the new treatment at least 9 patients treated with apomorphine, there would not be an increase in costs for the NHS. Conclusion: The new care system would respond to the unmet needs of patients with Parkinson’s disease by generating a reduction in the expenditure incurred by NHS.

Published
2023

21. Early and sustained efficacy of fremanezumab over 24-weeks in migraine patients with multiple preventive treatment failures. The multicenter, prospective, real-life FRIEND2 study.

Author

Barbanti, Piero, primary, Egeo, Gabriella, additional, Aurilia, Cinzia, additional, Torelli, Paola, additional, Finocchi, Cinzia, additional, d'Onofrio, Florindo, additional, d'Onorio, Luigi, additional, Rao, Renata, additional, Messina, Stefano, additional, Clemente, Laura Di, additional, Ranieri, Angelo, additional, Autunno, Massimo, additional, Sette, Giuliano, additional, Colombo, Bruno, additional, Carnevale, Antonio, additional, Aguggia, Marco, additional, Tasillo, Miriam, additional, Zoroddu, Francesco, additional, Frediani, Fabio, additional, Filippi, Massimo, additional, Fiorentini, Giulia, additional, Tomino, Carlo, additional, Proietti, Stefania, additional, and Bonassi, Stefano, additional

Published
2023
Full Text
View/download PDF

22. Tantali fibromyalgic supplicium: Is there any relief with the antidepressant employment? A systematic review

Author

Ilari, Sara, primary, Passacatini, Lucia Carmela, additional, Malafoglia, Valentina, additional, Oppedisano, Francesca, additional, Maiuolo, Jessica, additional, Gliozzi, Micaela, additional, Palma, Ernesto, additional, Tomino, Carlo, additional, Fini, Massimo, additional, Raffaeli, William, additional, Mollace, Vincenzo, additional, and Muscoli, Carolina, additional

Published
2022
Full Text
View/download PDF

23. A Systematic Review and Meta-Analysis on the Role of Nutraceuticals in the Management of Neuropathic Pain in In Vivo Studies

Author

Ilari, Sara, primary, Proietti, Stefania, additional, Russo, Patrizia, additional, Malafoglia, Valentina, additional, Gliozzi, Micaela, additional, Maiuolo, Jessica, additional, Oppedisano, Francesca, additional, Palma, Ernesto, additional, Tomino, Carlo, additional, Fini, Massimo, additional, Raffaeli, William, additional, Mollace, Vincenzo, additional, Bonassi, Stefano, additional, and Muscoli, Carolina, additional

Published
2022
Full Text
View/download PDF

26. Nicotine in Combination with SARS-CoV-2 Affects Cells Viability, Inflammatory Response and Ultrastructural Integrity

Author

Sansone, Luigi, primary, de Iure, Antonio, additional, Cristina, Mario, additional, Belli, Manuel, additional, Vitiello, Laura, additional, Marcolongo, Federica, additional, Rosellini, Alfredo, additional, Macera, Lisa, additional, Spezia, Pietro Giorgio, additional, Tomino, Carlo, additional, Bonassi, Stefano, additional, Russo, Matteo A., additional, Maggi, Fabrizio, additional, and Russo, Patrizia, additional

Published
2022
Full Text
View/download PDF

27. Fibromyalgia and Irritable Bowel Syndrome Interaction: A Possible Role for Gut Microbiota and Gut-Brain Axis.

Author

Garofalo, Cinzia, Cristiani, Costanza Maria, Ilari, Sara, Passacatini, Lucia Carmela, Malafoglia, Valentina, Viglietto, Giuseppe, Maiuolo, Jessica, Oppedisano, Francesca, Palma, Ernesto, Tomino, Carlo, Raffaeli, William, Mollace, Vincenzo, and Muscoli, Carolina

Subjects
IRRITABLE colon, GUT microbiome, ETIOLOGY of diseases, JOINT stiffness, FIBROMYALGIA, FATIGUE (Physiology)
Abstract

Fibromyalgia (FM) is a serious chronic pain syndrome, characterised by muscle and joint stiffness, insomnia, fatigue, mood disorders, cognitive dysfunction, anxiety, depression and intestinal irritability. Irritable Bowel Syndrome (IBS) shares many of these symptoms, and FM and IBS frequently co-exist, which suggests a common aetiology for the two diseases. The exact physiopathological mechanisms underlying both FM and IBS onset are unknown. Researchers have investigated many possible causes, including alterations in gut microbiota, which contain billions of microorganisms in the human digestive tract. The gut-brain axis has been proven to be the link between the gut microbiota and the central nervous system, which can then control the gut microbiota composition. In this review, we will discuss the similarities between FM and IBS. Particularly, we will focus our attention on symptomatology overlap between FM and IBS as well as the similarities in microbiota composition between FM and IBS patients. We will also briefly discuss the potential therapeutic approaches based on microbiota manipulations that are successfully used in IBS and could be employed also in FM patients to relieve pain, ameliorate the rehabilitation outcome, psychological distress and intestinal symptoms. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

28. Budget Impact analysis of a new system of care in Parkinson’s disease patients

Author

Bini, Chiara, Mennini, Francesco Saverio, Marcellusi, Andrea, Paoletti, Martina, Tomino, Carlo, Bini, Chiara, Mennini, Francesco Saverio, Marcellusi, Andrea, Paoletti, Martina, and Tomino, Carlo

Abstract

Objective: To estimate the economic impact of the introduction of a new care system based on apomorphine and Patient Support Program for motor fluctuations (“on-off” phenomena) in patients with Parkinson’s disease which are not sufficiently controlled by oral anti-Parkinson medication in Italy. Method: A Budget Impact model was developed to evaluate the new care system in patients with Parkinson’s disease over a 3-years’ time horizon. The comparator treatments included in the analysis were treatments based on apomorphine and levodopa + carbidopa. The analysis was conducted from a National Health Service (NHS) perspective. Costs included in the analysis were acquisition costs and device costs. A deterministic sensitivity analysis was carried out to evaluate the uncertainty of the parameters used. A break-even analysis was conducted to identify the minimum number of subjects that would need to be treated with the new care system to obtain a positive Budget Impact (World With – World Without = 0). Results: The analysis shows that the introduction of the new care system based on apomorphine could generate a cost saving incurred by the NHS of over € 5.7 million in 3 years. Break-even analysis shows that if it were possible to intercept with the new treatment at least 9 patients treated with apomorphine, there would not be an increase in costs for the NHS. Conclusion: The new care system would respond to the unmet needs of patients with Parkinson’s disease by generating a reduction in the expenditure incurred by NHS.

Published
2022

29. Economic evaluation of treosulfan in patients undergoing allogeneic haematopoietic stem cell transplantation

Author

Bini, Chiara, Paoletti, Martina, Marcellusi, Andrea, Tomino, Carlo, Mennini, Francesco Saverio, Bini, Chiara, Paoletti, Martina, Marcellusi, Andrea, Tomino, Carlo, and Mennini, Francesco Saverio

Abstract

Objective. To assess the cost-effectiveness and economic sustainability of treosulfan plus fludarabine compared with busulfan plus fludarabine as a conditioning treatment for malignant disease prior to allogeneic haematopoietic stem cell transplantation (alloHSCT) in adult patients in Italy. Method. The two theoretical cohorts of patients aged ≥ 60 years with acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) were pooled and followed over time using a partitioned survival model with cycles of 28 days. Patients can transition between a post-HSCT recovery/remission state (Event-Free Survival state, EFS state), a relapsed/progressed disease state, and a death state. A lifetime horizon for cost-effectiveness analysis and a 5-years’ time horizon for budget impact analysis were used. The perspective of the Italian National Health Service was adopted. Utility values were obtained from published sources. Costs included: drug acquisition, HSCT procedure, management and treatment of adverse reactions, graft-versus-host disease (GvHD) and health states, end of life treatment. Discounting of 3% per year was applied for both costs and outcomes according to Italian guidelines. Sensitivity was tested through both one-way and probabilistic analyses. Results. Cost-effectiveness analysis showed that treosulfan is both more effective and less expensive compared with busulfan (+1.11 life-years, +0.96 quality-adjusted life-years per patient and -€ 41,784 per patient). On the side of economic sustainability, the introduction of treosulfan in the market could generate a cumulative decrement of the expense incurred by NHS of about -€ 179,174 over five years. Conclusion. Treosulfan could represent a cost-effective and sustainable treatment alternative from the perspective of the NHS.

Published
2022

30. Preventive Measures against Pandemics from the Beginning of Civilization to Nowadays—How Everything Has Remained the Same over the Millennia

Author

Vitiello, Laura, primary, Ilari, Sara, additional, Sansone, Luigi, additional, Belli, Manuel, additional, Cristina, Mario, additional, Marcolongo, Federica, additional, Tomino, Carlo, additional, Gatta, Lucia, additional, Mollace, Vincenzo, additional, Bonassi, Stefano, additional, Muscoli, Carolina, additional, and Russo, Patrizia, additional

Published
2022
Full Text
View/download PDF

32. Efficacy and Safety of Novel Aspirin Formulations: A Randomized, Double-Blind, Placebo-Controlled Study

Author

Mollace, Rocco, primary, Gliozzi, Micaela, additional, Macrì, Roberta, additional, Tavernese, Annamaria, additional, Musolino, Vincenzo, additional, Carresi, Cristina, additional, Maiuolo, Jessica, additional, Muscoli, Carolina, additional, Tomino, Carlo, additional, Rosano, Giuseppe Maria, additional, Fini, Massimo, additional, Volterrani, Maurizio, additional, Silvestrini, Bruno, additional, and Mollace, Vincenzo, additional

Published
2022
Full Text
View/download PDF

34. The Protective Effect of Bergamot Polyphenolic Fraction (BPF) on Chemotherapy-Induced Neuropathic Pain

Author

Ilari, Sara, primary, Lauro, Filomena, additional, Giancotti, Luigino Antonio, additional, Malafoglia, Valentina, additional, Dagostino, Concetta, additional, Gliozzi, Micaela, additional, Condemi, Antonia, additional, Maiuolo, Jessica, additional, Oppedisano, Francesca, additional, Palma, Ernesto, additional, Tomino, Carlo, additional, Salvemini, Daniela, additional, Mollace, Vincenzo, additional, and Muscoli, Carolina, additional

Published
2021
Full Text
View/download PDF

36. Sub-Lingual Immunotherapy: World Allergy Organization Position Paper 2009

Author

Canonica, G. Walter, Bousquet, Jean, Casale, Thomas, Lockey, Richard F., Baena-Cagnani, Carlos E., Pawankar, Ruby, Potter, Paul C., Bousquet, Philippe J., Cox, Linda S., Durham, Stephen R., Nelson, Harold S., Passalacqua, Giovanni, Ryan, Dermot P., Brozek, Jan L., Compalati, Enrico, Dahl, Ronald, Delgado, Luis, van Wijk, Roy Gerth, Gower, Richard G., Ledford, Dennis K., Filho, Nelson Rosario, Valovirta, Erkka J., Yusuf, Osman M., Zuberbier, Torsten, Akhanda, Wahiduzzaman, Almarales, Raul Castro, Ansotegui, Ignacio, Bonifazi, Floriano, Ceuppens, Jan, Chivato, Tomás, Dimova, Darina, Dumitrascu, Diana, Fontana, Luigi, Katelaris, Constance H., Kaulsay, Ranbir, Kuna, Piotr, Larenas-Linnemann, Désirée, Manoussakis, Manolis, Nekam, Kristof, Nunes, Carlos, O'Hehir, Robyn, Olaguibel, José M., Onder, Nerin Bahceciler, Park, Jung Won, Priftanji, Alfred, Puy, Robert, Sarmiento, Luis, Scadding, Glenis, Schmid-Grendelmeier, Peter, Seberova, Ester, Sepiashvili, Revaz, Solé, Dírceu, Togias, Alkis, Tomino, Carlo, Toskala, Elina, Van Beever, Hugo, and Vieths, Stefan

Published
2009
Full Text
View/download PDF

40. SARS-CoV-2 epidemiological surveillance of healthcare professionals working in an inpatient rehabilitation facility

Author

Tomino, Carlo, primary, Limongi, Dolores, additional, Checconi, Paola, additional, Ambrosi, Cecilia, additional, Gatta, Lucia, additional, Vitiello, Laura, additional, Prezioso, Carla, additional, Proietti, Stefania, additional, Marcolongo, Federica, additional, Pour, Neda Soltan, additional, Palamara, Anna Teresa, additional, Bonassi, Stefano, additional, and Russo, Patrizia, additional

Published
2021
Full Text
View/download PDF

41. Daily Vegetables Intake and Response to COPD Rehabilitation. The Role of Oxidative Stress, Inflammation and DNA Damage The role of oxidative stress, inflammation and DNA damage

Author

Ilari, Sara, Vitiello, Laura, Russo, Patrizia, Proietti, Stefania, Milić, Mirta, Muscoli, Carolina, Cardaci, Vittorio, Tomino, Carlo, Bonassi, Gaia, and Bonassi, Stefano

Subjects
Chronic obstructive pulmonary disease (COPD), Pulmonary Rehabilitation, Vegetables, DNA damage, Genomic Instability, Oxidative stress, Inflammation
Abstract

Chronic obstructive pulmonary disease (COPD) is a respiratory disease associated with airways inflammation and lung parenchyma fibrosis. The primary goals of COPD treatment are to reduce symptoms and risk of exacerbations, therefore pulmonary rehabilitation is considered the key component of managing COPD patients. Oxidative airway damage, inflammation and reduction of endogenous antioxidant enzymes are known to play a crucial role in the pathogenesis of COPD. Natural antioxidants have also recently been considered as they play an important role in metabolism, DNA repair and fighting the effects of oxidative stress. In this paper we evaluated the response of 105 elderly COPD patients to pulmonary rehabilitation (PR), based on high or low vegetable consumption, by analyzing clinical parameters and biological measurements at baseline and after completion of the three weeks PR. We found that high vegetable intake in normal diet, without any specific intervention, can increase the probability to successfully respond to rehabilitation (65.4% of responders ate vegetables daily vs. 40.0% of Non-Responders, p=0.033). Three weeks of pulmonary rehabilitation are probably too short to reveal a reduction of the oxidative stress and DNA damage, but are enough to show an improvement in the patient's inflammatory state.

Published
2021

42. A Randomized Trial (ISS 902) of Didanosine versus Zidovudine in Previously Untreated Patients with Mildly Symptomatic Human Immunodeficiency Virus Infection

Author

Floridia, Marco, Vella, Stefano, Seeber, Angela C., Tomino, Carlo, Fragola, Vincenzo, Weimer, Liliana E., Ricciardulli, Daniela, Milazzo, Francesco, Gritti, Francesco M., Mazzotta, Francesco, Ranieri, Sergio, Chiodo, Francesco, Moroni, Mauro, Cargnel, Antonietta, Bassetti, Dante, Giannini, Valerio, Cremoni, Luisella, Concia, Ercole, Sinicco, Alessandro, Carosi, Giampiero, Alberici, Francesco, and Dianzani, Ferdinando

Published
1997

50. Natural Antioxidant Control of Neuropathic Pain—Exploring the Role of Mitochondrial SIRT3 Pathway

Author

Ilari, Sara, primary, Giancotti, Luigino Antonio, additional, Lauro, Filomena, additional, Gliozzi, Micaela, additional, Malafoglia, Valentina, additional, Palma, Ernesto, additional, Tafani, Marco, additional, Russo, Matteo Antonio, additional, Tomino, Carlo, additional, Fini, Massimo, additional, Salvemini, Daniela, additional, Mollace, Vincenzo, additional, and Muscoli, Carolina, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results