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4. Utility of bilateral intraductal plastic stent for malignant hilar biliary obstruction compared with bilateral self-expandable metal stent: a propensity score–matched cohort analysis

Author

Okuno, Mitsuru, Iwata, Keisuke, Iwashita, Takuji, Mukai, Tsuyoshi, Shimojo, Kota, Ohashi, Yosuke, Iwasa, Yuhei, Senju, Akihiko, Iwata, Shota, Tezuka, Ryuichi, Ichikawa, Hironao, Mita, Naoki, Uemura, Shinya, Yoshida, Kensaku, Maruta, Akinori, Tomita, Eiichi, Yasuda, Ichiro, and Shimizu, Masahito

Published
2023
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5. Prediction of Liver-Related Events With a Combination of Liver Stiffness Measurements and Controlled Attenuation Parameters in Japanese Patients With Biopsy-Proven Non-alcoholic Fatty Liver Disease

Author

Hayashi, Hideki, Kamada, Yoshihiro, Fujii, Hideki, Takahashi, Hirokazu, Oeda, Satoshi, Iwaki, Michihiro, Kawaguchi, Takumi, Tomita, Eiichi, Yoneda, Masato, Tokushige, Akihiro, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Nakajima, Atsushi, and Okanoue, Takeshi

Published
2023
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8. Clinical Outcomes in Biopsy-Proven Nonalcoholic Fatty Liver Disease Patients: A Multicenter Registry-based Cohort Study

Author

Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Yamamura, Sakura, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, Kawaguchi, Takumi, Noritake, Hidenao, Ono, Masafumi, Masaki, Tsutomu, Yasuda, Satoshi, Tomita, Eiichi, Yoneda, Masato, Kawada, Norifumi, Tokushige, Akihiro, Kamada, Yoshihiro, Takahashi, Hirokazu, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Nakajima, Atsushi, and Okanoue, Takeshi

Published
2023
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9. Validation of Noninvasive Markers for HCC Risk Stratification in 1389 Patients With Biopsy-proven NAFLD

Author

Toyoda, Hidenori, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Yamamura, Sakura, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, Kawaguchi, Takumi, Noritake, Hidenao, Ono, Masafumi, Masaki, Tsutomu, Yasuda, Satoshi, Tomita, Eiichi, Yoneda, Masato, Kawada, Norifumi, Tokushige, Akihiro, Kamada, Yoshihiro, Takahashi, Hirokazu, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Nakajima, Atsushi, and Okanoue, Takeshi

Published
2023
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10. Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort

Author

Furumatsu, Keisuke, Sawai, Shigeaki, Goto, Takuma, Okumura, Toshikatsu, Suzuki, Daisuke, Otsuka, Masayuki, Kobori, Ikuhiro, Tamano, Masaya, Koizumi, Mitsuhito, Hiasa, Yoichi, Kawabe, Naoto, Hirooka, Yoshiki, Yamamoto, Satoshi, Asano, Yukio, Inui, Kazuo, Horiguchi, Akihiko, Watanabe, Hiroyuki, Toya, Daishu, Hatayama, Katsuko, Ueki, Toshiharu, Kinoshita, Norikatsu, Sugimoto, Mitsuru, Ohira, Hiromasa, Mukai, Tsuyoshi, Tomita, Eiichi, Iwata, Keisuke, Shimizu, Shogo, Suetsugu, Jun, Shimizu, Masahito, Tsuji, Keiji, Ishida, Ryoko, Ito, Masanori, Furukawa, Ryutaro, Sakamoto, Naoya, Araki, Masahiro, Tanno, Satoshi, Sakamoto, Yasunari, Ito, Tetsuhide, Takai, Satoshi, Ikeya, Shinichi, Yamada, Takanori, Kudara, Norihiko, Shimizu, Akinori, Hanada, Keiji, Ichiki, Yasunori, Kitada, Hideki, Hifumi, Michio, Kimura, Hiroyuki, Kurosaki, Masayuki, Izumi, Namiki, Sumi, Hajime, Haruta, Jun-ichi, Hayashi, Katsumi, Harada, Ryo, Inoue, Masafumi, Nakamura, Shinichiro, Ito, Tetsuya, Tomishima, Ko, Isayama, Hiroyuki, Oura, Kyoko, Masaki, Tsutomu, Shimokawahara, Naoto, Tanoue, Shirou, Maemura, Kousei, Ido, Akio, Mizushima, Ichiro, Kawano, Mitsuhiro, Yoshida, Katsunori, Naganuma, Makoto, Murata, Miki, Nishio, Akiyoshi, Fujita, Yuji, Teratani, Takuma, Matsubara, Shohei, Tamai, Hironao, Yoshida, Yuu, Azemoto, Ryousaku, Kamata, Ken, Watanabe, Tomohiro, Kurosu, Takahiro, Koizumi, Wasaburou, Fujita, Jun, Seki, Hideyuki, Ueda, Yasuhiro, Fukumoto, Takumi, Kousaki, Takuhiro, Uchida, Kazushige, Ochiai, Toshimasa, Kawasaki, Takeshi, Tanaka, Motohiko, Ishida, Etsuji, Notohara, Kenji, Mori, Hideaki, Mori, Toshiyuki, Kawabata, Hideaki, Miyata, Masatoshi, Sakagami, Junichi, Itoh, Yoshito, Shiokawa, Masahiro, Seno, Hiroshi, Watanabe, Noriko, Naitoh, Itaru, Kataoka, Hiromi, Aoki, Toshinori, Fujishiro, Mitsuhiro, Niihara, Toru, Nishimata, Hiroto, Mitoro, Akira, Yoshiji, Hitoshi, Yoshida, Motoyuki, Ikeda, Masafumi, Tomita, Kengo, Hokari, Ryota, Hayasaka, Kenji, Amano, Yuji, Shioji, Kazuhiko, Hayashi, Kazunao, Terai, Shuji, Nakajima, Michiko, Yamahana, Junya, Matsumoto, Ryusuke, Kikuchi, Hideaki, Kanamori, Akira, Kiriyama, Seiki, Iwatsu, Shinichi, Kato, Yuji, Horiguchi, Shigeru, Yagi, Takahito, Okada, Hiroyuki, Ohkawa, Kazuyoshi, Hirao, Motohiro, Hiramatsu, Naoki, Oza, Noriko, Imamura, Haruo, Baba, Takeshi, Nakano, Shigeru, Shinobi, Tetsuya, Ryozawa, Shomei, Motoya, Masayo, Nakase, Hiroshi, Kinoshita, Noboru, Ito, Kei, Miyake, Tatsuya, Kohge, Naruaki, Tobita, Hiroshi, Joshita, Satoru, Umemura, Takeji, Kawaguchi, Shinya, Ohno, Kazuya, Sonobe, Koichi, Satoh, Akihiko, Shimosegawa, Tooru, Miura, Fumihiko, Yagi, Minami, Sano, Keiji, Tanaka, Atsushi, Kin, Toshifumi, Katanuma, Akio, Koike, Kazuhiko, Miura, Shin, Masamune, Atsushi, Kawashima, Youhei, Kagawa, Tatehiro, Azuma, Seishin, Watanabe, Mamoru, Honjyo, Mitsuyoshi, Itoi, Takao, Honda, Akira, Kobayashi, Katsumasa, Asano, Toru, Kamisawa, Terumi, Mizuno, Suguru, Nishino, Takayoshi, Taniguchi, Hideaki, Tajiri, Kazuto, Yasuda, Ichiro, Tanaka, Yoshiya, Oe, Shinji, Harada, Masaru, Kurata, Masanao, Fukasawa, Mituharu, Enomoto, Nobuyuki, Kawaji, Yuki, Kitano, Masayuki, Nishise, Yuko, Hirakawa, Hidetoshi, Ishizawa, Tetsuya, Ueno, Yoshiyuki, Kaino, Miyuki, Fujimoto, Yuko, Sakaida, Isao, Kubota, Kensuke, Nakazawa, Takahiro, Takikawa, Hajime, Unno, Michiaki, Kawa, Shigeyuki, Nakamura, Seiji, and Okazaki, Kazuichi

Published
2021
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11. Evaluating optimal bilateral biliary stenting in endoscopic reintervention after initial plastic stent dysfunction for unresectable malignant hilar biliary obstruction: Retrospective cross‐sectional study.

Author

Okuno, Mitsuru, Iwata, Keisuke, Iwashita, Takuji, Mukai, Tsuyoshi, Shimojo, Kota, Ohashi, Yosuke, Iwasa, Yuhei, Senju, Akihiko, Iwata, Shota, Tezuka, Ryuichi, Ichikawa, Hironao, Mita, Naoki, Uemura, Shinya, Yoshida, Kensaku, Maruta, Akinori, Tomita, Eiichi, Yasuda, Ichiro, and Shimizu, Masahito

Subjects
OVERALL survival, MULTIVARIATE analysis, CONFIDENCE intervals, DRAINAGE, RETROSPECTIVE studies
Abstract

Objectives: The placement of plastic stents (PS), including intraductal PS (IS), is useful in patients with unresectable malignant hilar biliary obstruction (UMHBO) because of patency and ease of endoscopic reintervention (ERI). However, the optimal stent replacement method for PS remains unclear. Methods: This retrospective study included 322 patients with UMHBO. Among them, 146 received PS placement as initial drainage (across‐the‐papilla PS [aPS], 54; IS, 92), whereas 75 required ERI. Eight bilateral aPS, 21 bilateral IS, and 17 bilateral self‐expandable metallic stent (SEMS) placements met the inclusion criteria. Rates of technical and clinical success, adverse events, recurrent biliary obstruction (RBO), time to RBO (TRBO), overall survival, and secondary ERI were compared. Results: There were no significant intergroup differences in rates of technical or clinical success, adverse events, RBO occurrence, or overall survival. The median TRBO was significantly shorter in the aPS group (47 days) than IS (91 days; P = 0.0196) and SEMS (143 days; P < 0.01) groups. Median TRBO did not differ significantly between the IS and SEMS groups (P = 0.44). On Cox multivariate analysis, the aPS group had the shortest stent patency (hazard ratio 2.67 [95% confidence interval 1.05–6.76], P = 0.038). For secondary ERI, the median endoscopic procedure time was significantly shorter in the IS (22 min) vs. SEMS (40 min) group (P = 0.034). Conclusions: Bilateral IS and SEMS placement featured prolonged patency after first ERI. Because bilateral IS placement is faster than SEMS placement and IS can be removed during secondary ERI, it may be a good option for first ERI. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Hepatic inflammation and fibrosis are profiles related to mid‐term mortality in biopsy‐proven MASLD: A multicenter study in Japan

Author

Tsutsumi, Tsubasa, primary, Kawaguchi, Takumi, additional, Fujii, Hideki, additional, Kamada, Yoshihiro, additional, Takahashi, Hirokazu, additional, Kawanaka, Miwa, additional, Sumida, Yoshio, additional, Iwaki, Michihiro, additional, Hayashi, Hideki, additional, Toyoda, Hidenori, additional, Oeda, Satoshi, additional, Hyogo, Hideyuki, additional, Morishita, Asahiro, additional, Munekage, Kensuke, additional, Kawata, Kazuhito, additional, Sawada, Koji, additional, Maeshiro, Tatsuji, additional, Tobita, Hiroshi, additional, Yoshida, Yuichi, additional, Naito, Masafumi, additional, Araki, Asuka, additional, Arakaki, Shingo, additional, Noritake, Hidenao, additional, Ono, Masafumi, additional, Masaki, Tsutomu, additional, Yasuda, Satoshi, additional, Tomita, Eiichi, additional, Yoneda, Masato, additional, Tokushige, Akihiro, additional, Ueda, Shinichiro, additional, Aishima, Shinichi, additional, Nakajima, Atsushi, additional, and Okanoue, Takeshi, additional

Published
2024
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13. Possibility of Cell Block Specimens from Overnight-Stored Bile for Next-Generation Sequencing of Cholangiocarcinoma.

Author

Okuno, Mitsuru, Kanayama, Tomohiro, Iwata, Keisuke, Tanaka, Takuji, Tomita, Hiroyuki, Iwasa, Yuhei, Shirakami, Yohei, Watanabe, Naoki, Mukai, Tsuyoshi, Tomita, Eiichi, and Shimizu, Masahito

Subjects
NUCLEOTIDE sequencing, CHOLANGIOCARCINOMA, GENETIC variation, POSSIBILITY
Abstract

The identification of anticancer therapies using next-generation sequencing (NGS) is necessary for the treatment of cholangiocarcinoma. NGS can be easily performed when cell blocks (CB) are obtained from bile stored overnight. We compared NGS results of paired CB and surgically resected specimens (SRS) from the same cholangiocarcinoma cases. Of the prospectively collected 64 bile CBs from 2018 to 2023, NGS was performed for three cases of cholangiocarcinoma that could be compared with the SRS results. The median numbers of DNA and RNA reads were 95,077,806 [CB] vs. 93,161,788 [SRS] and 22,101,328 [CB] vs. 24,806,180 [SRS], respectively. We evaluated 588 genes and found that almost all genetic alterations were attributed to single-nucleotide variants, insertions/deletions, and multi-nucleotide variants. The coverage rate of variants in SRS by those found in CB was 97.9–99.2%, and the coverage rate of SRS genes by CB genes was 99.6–99.7%. The NGS results of CB fully covered the variants and genetic alterations observed in paired SRS samples. As bile CB is easy to prepare in general hospitals, our results suggest the potential use of bile CB as a novel method for NGS-based evaluation of cholangiocarcinoma. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Comparison of 19-gauge conventional and Franseen needles for the diagnosis of lymphadenopathy and classification of malignant lymphoma using endoscopic ultrasound fine-needle aspiration.

Author

Okuno, Mitsuru, Iwata, Keisuke, Mukai, Tsuyoshi, Kito, Yusuke, Tanaka, Takuji, Watanabe, Naoki, Kasahara, Senji, Iwasa, Yuhei, Sugiyama, Akihiko, Nishigaki, Youichi, Shibata, Yuhei, Kitagawa, Junichi, Iwashita, Takuji, Tomita, Eiichi, and Shimizu, Masahito

Subjects
ENDOSCOPIC ultrasonography, NEEDLE biopsy, LYMPHADENITIS, LYMPHOMAS, DIAGNOSIS, NEEDLES & pins
Abstract

Background/Aims: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) using a 19-gauge needle is an efficient sampling method for the diagnosis of lymphadenopathy. This study compared 19-gauge conventional and Franseen needles for the diagnosis of lymphadenopathy and classification of malignant lymphoma (ML). Methods: Patient characteristics, number of needle passes, puncture route, sensitivity, specificity, and accuracy of cytology/histology for lymphadenopathy were analyzed in patients diagnosed with lymphadenopathy by EUS-FNA using conventional or Franseen needles. Results: Between 2012 and 2022, 146 patients met the inclusion criteria (conventional [n=70] and Franseen [n=76]). The median number of needle passes was significantly lower in the conventional group than in the Franseen group (3 [1-6] vs. 4 [1-6], p=0.023). There were no significant differences in cytological/histological diagnoses between the two groups. For ML, the immunohistochemical evaluation rate, sensitivity of flow cytometry, and cytogenetic assessment were not significantly different in either group. Bleeding as adverse events (AEs) were observed in three patients in the Franseen group. Conclusions: Both the 19-gauge conventional and Franseen needles showed high accuracy in lymphadenopathy and ML classification. Considering sufficient tissue collection and the avoidance of AEs, the use of 19-gauge conventional needles seems to be a good option for the diagnosis of lymphadenopathy. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Hepatitis E virus subtype 3f strains isolated from Japanese hepatitis patients with no history of travel to endemic areas – The origin analyzed by molecular evolution

Author

Nakano, Tatsunori, Takahashi, Masaharu, Takahashi, Kazuaki, Nagashima, Shigeo, Suzuki, Yusuke, Nishigaki, Yoichi, Tomita, Eiichi, Okano, Hiroshi, Oya, Yumi, Shiraki, Katsuya, Takase, Kojiro, Sugimoto, Kazushi, Koyama, Junichi, Mizuo, Hitoshi, Ikezawa, Kazuto, Aikawa, Tatsuya, Arai, Masahiro, and Okamoto, Hiroaki

Published
2018
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18. Comparison of 19-gauge conventional and Franseen needles for the diagnosis of lymphadenopathy and classification of malignant lymphoma using endoscopic ultrasound fine-needle aspiration

Author

Okuno, Mitsuru, primary, Iwata, Keisuke, additional, Mukai, Tsuyoshi, additional, Kito, Yusuke, additional, Tanaka, Takuji, additional, Watanabe, Naoki, additional, Kasahara, Senji, additional, Iwasa, Yuhei, additional, Sugiyama, Akihiko, additional, Nishigaki, Youichi, additional, Shibata, Yuhei, additional, Kitagawa, Junichi, additional, Iwashita, Takuji, additional, Tomita, Eiichi, additional, and Shimizu, Masahito, additional

Published
2023
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19. Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection

Author

Matsuura, Kentaro, Sawai, Hiromi, Ikeo, Kazuho, Ogawa, Shintaro, Iio, Etsuko, Isogawa, Masanori, Shimada, Noritomo, Komori, Atsumasa, Toyoda, Hidenori, Kumada, Takashi, Namisaki, Tadashi, Yoshiji, Hitoshi, Sakamoto, Naoya, Nakagawa, Mina, Asahina, Yasuhiro, Kurosaki, Masayuki, Izumi, Namiki, Enomoto, Nobuyuki, Kusakabe, Atsunori, Kajiwara, Eiji, Itoh, Yoshito, Ide, Tatsuya, Tamori, Akihiro, Matsubara, Misako, Kawada, Norifumi, Shirabe, Ken, Tomita, Eiichi, Honda, Masao, Kaneko, Shuichi, Nishina, Sohji, Suetsugu, Atsushi, Hiasa, Yoichi, Watanabe, Hisayoshi, Genda, Takuya, Sakaida, Isao, Nishiguchi, Shuhei, Takaguchi, Koichi, Tanaka, Eiji, Sugihara, Junichi, Shimada, Mitsuo, Kondo, Yasuteru, Kawai, Yosuke, Kojima, Kaname, Nagasaki, Masao, Tokunaga, Katsushi, and Tanaka, Yasuhito

Published
2017
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20. Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection

Author

Akuta, Norio, Toyota, Joji, Karino, Yoshiyasu, Ikeda, Fusao, Ido, Akio, Tanaka, Katsuaki, Takaguchi, Koichi, Naganuma, Atsushi, Tomita, Eiichi, Chayama, Kazuaki, Fujiyama, Shigetoshi, Inada, Yukiko, Yoshiji, Hitoshi, Watanabe, Hideaki, Ishikawa, Hiroki, McPhee, Fiona, Noviello, Stephanie, and Kumada, Hiromitsu

Published
2018
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21. Age‐dependent effects of diabetes and obesity on liver‐related events in non‐alcoholic fatty liver disease: Subanalysis of CLIONE in Asia

Author

Seko, Yuya, Kawanaka, Miwa, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Yamamura, Sakura, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, Kawaguchi, Takumi, Noritake, Hidenao, Ono, Masafumi, Masaki, Tsutomu, Yasuda, Satoshi, Tomita, Eiichi, Yoneda, Masato, Tokushige, Akihiro, Kamada, Yoshihiro, Takahashi, Hirokazu, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Okanoue, Takeshi, Itoh, Yoshito, Nakajima, Atsushi, and Japan Study Group of Nonalcoholic Fatty Liver Disease

Subjects
2型糖尿病, nonalcoholic fatty liver disease, Carcinoma, Hepatocellular, 肝細胞癌, type 2 diabetes mellitus, CLIONE in Asia, 肥満, BMI, Non-alcoholic Fatty Liver Disease, Humans, Animals, Obesity, nonalcoholic steatohepatitis, Retrospective Studies, 線維症, Clione, Hepatology, Liver Neoplasms, Gastroenterology, hepatocellular carcinoma, 非アルコール性脂肪性肝疾患, Middle Aged, Fibrosis, age, Diabetes Mellitus, Type 2, 非アルコール性脂肪性肝炎, liver-related events
Abstract

Older age, type 2 diabetes mellitus (T2DM), and obesity are known risk factors for liver-related events (LREs). We investigated the impacts of T2DM and obesity on LRE according to age in Japanese patients with non-alcoholic fatty liver disease (NAFLD).We performed a subanalysis of a retrospective cohort study (CLIONE in Asia), including 1395 patients with biopsy-proven NAFLD. The median follow-up was 4.6 years.The median age was 57 years, and 36.2% had T2DM. The median body mass index (BMI) was 27.4, and 28.5% were severely obese (BMI ≥ 30). During follow-up, 37 patients developed hepatocellular carcinoma (HCC), and 58 patients developed LRE. In patients younger than 65 years, advanced fibrosis (hazard ratio [HR] 7.69, P 0.001) and T2DM (HR 3.37, P = 0.017) were HCC risk factors, and advanced fibrosis (HR 9.40, P 0.001) and T2DM (HR 2.51, P = 0.016) were LRE risk factors. In patients 65 years and older, advanced fibrosis (HR 4.24, P = 0.010) and obesity (HR 4.60, P = 0.006) were HCC risk factors, and advanced fibrosis (HR 4.22, P = 0.002) and obesity (HR 4.22, P = 0.002) were LRE risk factors.Type 2 diabetes mellitus and obesity contributed to LRE in younger and older patients, respectively, along with advanced fibrosis. Therefore, controlling T2DM in patients younger than 65 years and controlling weight in patients 65 years and older could prevent LRE. The development of age-dependent screening and management strategies is necessary for patients with NAFLD.

Published
2022
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22. Serum levels of type IV collagen 7S can predict liver-related mortality and events as well as advanced fibrosis: a multi-center study

Author

Ishiba, Hiroshi, primary, Sumida, Yoshio, additional, Kamada, Yoshihiro, additional, Fujii, Hideki, additional, Iwaki, Michihiro, additional, Hayashi, Hideki, additional, Toyoda, Hidenori, additional, Oeda, Satoshi, additional, Hyogo, Hideyuki, additional, Kawanaka, Miwa, additional, Morishita, Asahiro, additional, Munekage, Kensuke, additional, Kawata, Kazuhito, additional, Tsutsumi, Tsubasa, additional, Sawada, Koji, additional, Maeshiro, Tatsuji, additional, Tobita, Hiroshi, additional, Yoshida, Yuichi, additional, Naito, Masafumi, additional, Araraki, Shingo, additional, Kawaguchi, Takumi, additional, Noritake, Hiedenao, additional, Ono, Masafumi, additional, Masaki, Tsutomu, additional, Yasuda, Satoshi, additional, Tomita, Eiichi, additional, Yoneda, Masato, additional, Tokushige, Akihiro, additional, Takahashi, Hirokazu, additional, Ueda, Shinichiro, additional, Nakajima, Atsushi, additional, and Okanoue, Takeshi, additional

Published
2023
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24. Daclatasvir/asunaprevir/beclabuvir fixed-dose combination in Japanese patients with HCV genotype 1 infection

Author

Toyota, Joji, Karino, Yoshiyasu, Suzuki, Fumitaka, Ikeda, Fusao, Ido, Akio, Tanaka, Katsuaki, Takaguchi, Koichi, Naganuma, Atsushi, Tomita, Eiichi, Chayama, Kazuaki, Fujiyama, Shigetoshi, Inada, Yukiko, Yoshiji, Hitoshi, Watanabe, Hideaki, Ishikawa, Hiroki, Hu, Wenhua, McPhee, Fiona, Linaberry, Misti, Yin, Philip D., Swenson, Eugene Scott, and Kumada, Hiromitsu

Published
2017
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25. A multicenter, retrospective, cohort study shows platelet counts predict HCC development in patients with NAFLD

Author

Fujii, Hideki, primary, Fujii, Makoto, additional, Iwaki, Michihiro, additional, Hayashi, Hideki, additional, Toyoda, Hidenori, additional, Oeda, Satoshi, additional, Hyogo, Hideyuki, additional, Kawanaka, Miwa, additional, Morishita, Asahiro, additional, Munekage, Kensuke, additional, Kawata, Kazuhito, additional, Tsutsumi, Tsubasa, additional, Sawada, Koji, additional, Maeshiro, Tatsuji, additional, Tobita, Hiroshi, additional, Yoshida, Yuichi, additional, Naito, Masafumi, additional, Araki, Asuka, additional, Arakaki, Shingo, additional, Kawaguchi, Takumi, additional, Noritake, Hidenao, additional, Ono, Masafumi, additional, Masaki, Tsutomu, additional, Yasuda, Satoshi, additional, Tomita, Eiichi, additional, Yoneda, Masato, additional, Kawada, Norifumi, additional, Tokushige, Akihiro, additional, Kamada, Yoshihiro, additional, Takahashi, Hirokazu, additional, Ueda, Shinichiro, additional, Aishima, Shinichi, additional, Sumida, Yoshio, additional, Nakajima, Atsushi, additional, and Okanoue, Takeshi, additional

Published
2023
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28. Association of serum albumin levels and long-term prognosis in patients with biopsy- confirmed nonalcoholic fatty liver disease

Author

Takahashi, Hirokazu, primary, Kawanaka, Miwa, additional, Fujii, Hideki, additional, Iwaki, Michihiro, additional, Hayashi, Hideki, additional, Toyoda, Hidenori, additional, Oeda, Satoshi, additional, Hyogo, Hideyuki, additional, Morishita, Asahiro, additional, Munekage, Kensuke, additional, Kawata, Kazuhito, additional, Tsutsumi, Tsubasa, additional, Sawada, Koji, additional, Maeshiro, Tatsuji, additional, Tobita, Hiroshi, additional, Yoshida, Yuichi, additional, Naito, Masafumi, additional, Araki, Asuka, additional, Arakaki, Shingo, additional, Kawaguch, Takumi, additional, Noritake, Hidenao, additional, Ono, Masafumi, additional, Masaki, Tsutomu, additional, Yasuda, Satoshi, additional, Tomita, Eiichi, additional, Yoneda, Masato, additional, Tokushige, Akihiro, additional, Kamada, Yoshihiro, additional, Ueda, Shinichiro, additional, Aishima, Shinichi, additional, Sumida, Yoshio, additional, Nakajima, Atsushi, additional, and Okanoue, Takeshi, additional

Published
2022
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30. The effect of ursodeoxycholic acid following self-expandable metallic stent placement in malignant distal biliary obstruction: A propensity score-matched cohort analysis

Author

Okuno, Mitsuru, primary, Iwata, Keisuke, additional, Mukai, Tsuyoshi, additional, Ohashi, Yosuke, additional, Iwata, Shota, additional, Iwasa, Yuhei, additional, Yoshida, Kensaku, additional, Maruta, Akinori, additional, Tezuka, Ryuichi, additional, Ichikawa, Hironao, additional, Mita, Naoki, additional, Uemura, Shinya, additional, Iwashita, Takuji, additional, Tomita, Eiichi, additional, and Shimizu, Masahito, additional

Published
2022
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31. Agile 3+ and Agile 4, noninvasive tests for liver fibrosis, are excellent formulae to predict liver‐related events in nonalcoholic fatty liver disease.

Author

Miura, Kouichi, Hayashi, Hideki, Kamada, Yoshihiro, Fujii, Hideki, Takahashi, Hirokazu, Oeda, Satoshi, Iwaki, Michihiro, Kawaguchi, Takumi, Tomita, Eiichi, Yoneda, Masato, Tokushige, Akihiro, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Nakajima, Atsushi, and Okanoue, Takeshi

Subjects
FATTY liver, NON-alcoholic fatty liver disease, HEPATIC fibrosis, ASIANS
Abstract

Aim: The noninvasive tests (NITs) Agile 3+ and Agile 4 effectively identify patients with nonalcoholic fatty liver disease (NAFLD) complicated with advanced fibrosis (F3–4) and cirrhosis (F4), respectively. Little information is available on associations between Agile scores and intra‐/extrahepatic events. The aim of this study was to determine the predictive performance of Agile scores for intra‐/extrahepatic events in Asian patients with biopsy‐proven NAFLD. Methods: We undertook a retrospective multicenter cohort study to investigate associations between intra‐/extrahepatic events and two Agile scores, Agile 3+ and Agile 4. The scores were obtained by combining clinical parameters and liver stiffness measurement using transient elastography. Results: Among 403 enrolled patients, 11 had liver‐related events (LREs), including seven with hepatocellular carcinoma (HCC). The incidence of LREs and HCC showed a stepwise increase in the advanced fibrosis group (F3–4), Agile 3+ rule‐in (F3–4, highly suspected), and Agile 4 rule‐in (F4, highly suspected) groups, compared to their counterparts. Hazard ratios for LREs in the advanced fibrosis group, Agile 3+ rule‐in, and Agile 4 rule‐in groups were 4.05 (p = 0.03), 23.5 (p = 0.003), and 45.5 (p < 0.001), respectively. The predictive performance results for Agile 3+ and Agile 4 were 0.780 and 0.866, respectively, which were higher than for fibrosis (0.595). Unlike for LREs, Agile scores failed to identify patients with extrahepatic events, including cardiovascular events and extrahepatic cancer. Conclusions: Agile 3+ and Agile 4 scores are excellent NITs for predicting LREs in patients with NAFLD, possibly without histological assessment. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Evaluation of the Cell Block Method Using Overnight-Stored Bile for Malignant Biliary Stricture Diagnosis

Author

Okuno, Mitsuru, primary, Mukai, Tsuyoshi, additional, Iwata, Keisuke, additional, Watanabe, Naoki, additional, Tanaka, Takuji, additional, Iwasa, Taisei, additional, Shimojo, Kota, additional, Ohashi, Yosuke, additional, Takagi, Akihiro, additional, Ito, Yuki, additional, Tezuka, Ryuichi, additional, Iwata, Shota, additional, Iwasa, Yuhei, additional, Kochi, Takahiro, additional, Ogiso, Tomio, additional, Hayashi, Hideki, additional, Sugiyama, Akihiko, additional, Nishigaki, Youichi, additional, and Tomita, Eiichi, additional

Published
2022
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37. Classification of hepatitis E virus diffusion patterns inferred by genome analysis: observation of 13 hepatitis E cases in Gifu, Japan

Author

Nakano, Tatsunori, primary, Nishigaki, Yoichi, additional, Hayashi, Hideki, additional, Tajirika, Satoko, additional, Iwasa, Taisei, additional, Tomita, Eiichi, additional, Suzuki, Yusuke, additional, Shimizu, Shogo, additional, Sugihara, Jun-ichi, additional, Nagashima, Shigeo, additional, Takahashi, Masaharu, additional, Okamoto, Hiroaki, additional, and Murata, Kazumoto, additional

Published
2022
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39. Overview of Earth, Clouds, Aerosols and Radiation Explorer (EarthCARE): Integrative Observation of Cloud and Aerosol and Their Radiative Effects on the Climate System

Author

KIKUCHI, Maki, OKI, Riko, KUBOTA, Takuji, YOSHIDA, Mayumi, HAGIHARA, Yuichiro, TAKAHASHI, Chikako, OHNO, Yuichi, NISHIZAWA, Tomoaki, NAKAJIMA, Takashi Y., SUZUKI, Kentaroh, SATOH, Masaki, OKAMOTO, Hajime, and TOMITA, Eiichi

Subjects
radiation, satellite remote sensing, aerosol, cloud, EarthCARE
Abstract

形態: カラー図版あり, Physical characteristics: Original contains color illustrations, Accepted: 2019-06-24, 資料番号: PA2010042000

Published
2019

44. Serum GP88 as a predictive biomarker for hepatocellular carcinoma in patients with viral hepatitis C after direct-acting antiviral agents

Author

Tomita Eiichi, Hidetoshi Matsunami, Yasuko Yamamoto, Kuniaki Saito, Masao Takemura, Ginette Serrero, Takafumi Naiki, Hidekazu Ishida, Takuji Tanaka, and Atsushi Suetsugu

Subjects
chemistry.chemical_classification, Carcinoma, Hepatocellular, business.industry, Growth factor, medicine.medical_treatment, Clinical Biochemistry, Liver Neoplasms, General Medicine, Hepatitis C, Chronic, medicine.disease, medicine.disease_cause, Antiviral Agents, Liver disease, chemistry, Hepatocellular carcinoma, medicine, Cancer research, Biomarkers, Tumor, Humans, In patient, Glycoprotein, Viral hepatitis, Carcinogenesis, business, Predictive biomarker
Abstract

Background Progranulin (GP88) is an 88-kDa glycoprotein growth factor with important biological effects in tumorigenesis and tumour survival. We investigated the usefulness of measuring serum GP88 concentrations as a predictive biomarker for hepatocellular carcinoma in patients with viral hepatitis C after treatment with direct-acting antiviral agents. Methods We measured the serum GP88 concentrations by using a sandwich enzyme-linked immunoassay from 67 healthy control subjects and 29 patients (20 patients who did not develop hepatocellular carcinoma and 9 patients who developed hepatocellular carcinoma after treatment) with viral hepatitis C after treatment with asunaprevir and daclatasvir. Results The serum GP88 concentrations of patients with chronic hepatitis C prior to antiviral treatment were significantly higher than those of healthy control subjects. After antiviral treatment, the serum GP88 concentrations of patients who eventually developed hepatocellular carcinoma were significantly higher than those who did not develop hepatocellular carcinoma. The changes in the serum GP88 concentrations before and after treatment in patients who developed hepatocellular carcinoma were significantly lower than those in patients who did not develop hepatocellular carcinoma. The cumulative incidence of hepatocellular carcinoma was significantly higher in either patients with high serum GP88 concentrations after treatment or those with small changes of serum GP88 concentrations pre- and post-treatment. Conclusions Sustained high concentrations of serum GP88 in patients treated with direct-acting antiviral agents are correlated with the risk of developing hepatocellular carcinoma.

Published
2021

48. Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort

Author

Naitoh, Itaru, primary, Kamisawa, Terumi, additional, Tanaka, Atsushi, additional, Nakazawa, Takahiro, additional, Kubota, Kensuke, additional, Takikawa, Hajime, additional, Unno, Michiaki, additional, Masamune, Atsushi, additional, Kawa, Shigeyuki, additional, Nakamura, Seiji, additional, Okazaki, Kazuichi, additional, Furumatsu, Keisuke, additional, Sawai, Shigeaki, additional, Goto, Takuma, additional, Okumura, Toshikatsu, additional, Suzuki, Daisuke, additional, Otsuka, Masayuki, additional, Kobori, Ikuhiro, additional, Tamano, Masaya, additional, Koizumi, Mitsuhito, additional, Hiasa, Yoichi, additional, Kawabe, Naoto, additional, Hirooka, Yoshiki, additional, Yamamoto, Satoshi, additional, Asano, Yukio, additional, Inui, Kazuo, additional, Horiguchi, Akihiko, additional, Watanabe, Hiroyuki, additional, Toya, Daishu, additional, Hatayama, Katsuko, additional, Ueki, Toshiharu, additional, Kinoshita, Norikatsu, additional, Sugimoto, Mitsuru, additional, Ohira, Hiromasa, additional, Mukai, Tsuyoshi, additional, Tomita, Eiichi, additional, Iwata, Keisuke, additional, Shimizu, Shogo, additional, Suetsugu, Jun, additional, Shimizu, Masahito, additional, Tsuji, Keiji, additional, Ishida, Ryoko, additional, Ito, Masanori, additional, Furukawa, Ryutaro, additional, Sakamoto, Naoya, additional, Araki, Masahiro, additional, Tanno, Satoshi, additional, Sakamoto, Yasunari, additional, Ito, Tetsuhide, additional, Takai, Satoshi, additional, Ikeya, Shinichi, additional, Yamada, Takanori, additional, Kudara, Norihiko, additional, Shimizu, Akinori, additional, Hanada, Keiji, additional, Ichiki, Yasunori, additional, Kitada, Hideki, additional, Hifumi, Michio, additional, Kimura, Hiroyuki, additional, Kurosaki, Masayuki, additional, Izumi, Namiki, additional, Sumi, Hajime, additional, Haruta, Jun-ichi, additional, Hayashi, Katsumi, additional, Harada, Ryo, additional, Inoue, Masafumi, additional, Nakamura, Shinichiro, additional, Ito, Tetsuya, additional, Tomishima, Ko, additional, Isayama, Hiroyuki, additional, Oura, Kyoko, additional, Masaki, Tsutomu, additional, Shimokawahara, Naoto, additional, Tanoue, Shirou, additional, Maemura, Kousei, additional, Ido, Akio, additional, Mizushima, Ichiro, additional, Kawano, Mitsuhiro, additional, Yoshida, Katsunori, additional, Naganuma, Makoto, additional, Murata, Miki, additional, Nishio, Akiyoshi, additional, Fujita, Yuji, additional, Teratani, Takuma, additional, Matsubara, Shohei, additional, Tamai, Hironao, additional, Yoshida, Yuu, additional, Azemoto, Ryousaku, additional, Kamata, Ken, additional, Watanabe, Tomohiro, additional, Kurosu, Takahiro, additional, Koizumi, Wasaburou, additional, Fujita, Jun, additional, Seki, Hideyuki, additional, Ueda, Yasuhiro, additional, Fukumoto, Takumi, additional, Kousaki, Takuhiro, additional, Uchida, Kazushige, additional, Ochiai, Toshimasa, additional, Kawasaki, Takeshi, additional, Tanaka, Motohiko, additional, Ishida, Etsuji, additional, Notohara, Kenji, additional, Mori, Hideaki, additional, Mori, Toshiyuki, additional, Kawabata, Hideaki, additional, Miyata, Masatoshi, additional, Sakagami, Junichi, additional, Itoh, Yoshito, additional, Shiokawa, Masahiro, additional, Seno, Hiroshi, additional, Watanabe, Noriko, additional, Naitoh, Itaru, additional, Kataoka, Hiromi, additional, Aoki, Toshinori, additional, Fujishiro, Mitsuhiro, additional, Niihara, Toru, additional, Nishimata, Hiroto, additional, Mitoro, Akira, additional, Yoshiji, Hitoshi, additional, Yoshida, Motoyuki, additional, Ikeda, Masafumi, additional, Tomita, Kengo, additional, Hokari, Ryota, additional, Hayasaka, Kenji, additional, Amano, Yuji, additional, Shioji, Kazuhiko, additional, Hayashi, Kazunao, additional, Terai, Shuji, additional, Nakajima, Michiko, additional, Yamahana, Junya, additional, Matsumoto, Ryusuke, additional, Kikuchi, Hideaki, additional, Kanamori, Akira, additional, Kiriyama, Seiki, additional, Iwatsu, Shinichi, additional, Kato, Yuji, additional, Horiguchi, Shigeru, additional, Yagi, Takahito, additional, Okada, Hiroyuki, additional, Ohkawa, Kazuyoshi, additional, Hirao, Motohiro, additional, Hiramatsu, Naoki, additional, Oza, Noriko, additional, Imamura, Haruo, additional, Baba, Takeshi, additional, Nakano, Shigeru, additional, Shinobi, Tetsuya, additional, Ryozawa, Shomei, additional, Motoya, Masayo, additional, Nakase, Hiroshi, additional, Kinoshita, Noboru, additional, Ito, Kei, additional, Miyake, Tatsuya, additional, Kohge, Naruaki, additional, Tobita, Hiroshi, additional, Joshita, Satoru, additional, Umemura, Takeji, additional, Kawaguchi, Shinya, additional, Ohno, Kazuya, additional, Sonobe, Koichi, additional, Satoh, Akihiko, additional, Shimosegawa, Tooru, additional, Miura, Fumihiko, additional, Yagi, Minami, additional, Sano, Keiji, additional, Kin, Toshifumi, additional, Katanuma, Akio, additional, Koike, Kazuhiko, additional, Miura, Shin, additional, Kawashima, Youhei, additional, Kagawa, Tatehiro, additional, Azuma, Seishin, additional, Watanabe, Mamoru, additional, Honjyo, Mitsuyoshi, additional, Itoi, Takao, additional, Honda, Akira, additional, Kobayashi, Katsumasa, additional, Asano, Toru, additional, Mizuno, Suguru, additional, Nishino, Takayoshi, additional, Taniguchi, Hideaki, additional, Tajiri, Kazuto, additional, Yasuda, Ichiro, additional, Tanaka, Yoshiya, additional, Oe, Shinji, additional, Harada, Masaru, additional, Kurata, Masanao, additional, Fukasawa, Mituharu, additional, Enomoto, Nobuyuki, additional, Kawaji, Yuki, additional, Kitano, Masayuki, additional, Nishise, Yuko, additional, Hirakawa, Hidetoshi, additional, Ishizawa, Tetsuya, additional, Ueno, Yoshiyuki, additional, Kaino, Miyuki, additional, Fujimoto, Yuko, additional, and Sakaida, Isao, additional

Published
2021
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