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1. Synthesis of 1-O-acyl- and 1-oxo-kamebanin analogues and their cytotoxic activity

Author

Aoyagi, Yutaka, primary, Tomita, Kaori, additional, Kobayashi, Asumi, additional, Nakamura, Akari, additional, Fujii, Yuki, additional, Yagi, Momoka, additional, Ichimaru, Yoshimi, additional, Ozawa, Kei, additional, Park, Hyun-Sun, additional, Fukaya, Haruhiko, additional, Yano, Reiko, additional, Hasuda, Tomoyo, additional, Takeya, Koichi, additional, Hitotsuyanagi, Yukio, additional, Gui, Ming-Yu, additional, Jin, Yong-Ri, additional, and Li, Xu-Wen, additional

Published
2023
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2. Changes in Pediatric Patient Trends in Eating and Swallowing Disorders: A Comparison between the First and Fifth Year after Establishment of the Special Needs Dental Center

Author

MASUDA, Emina, UTSUMI, Akemi, ISHIKAWA, Kentaro, ISHIZAKI, Akiko, KUBOTA, Kazumi, MURAKAMI, Kohji, TOMITA, Kaori, TAKAHASHI, Mari, OSAKABE, Luna, OGAWA, Ayano, ASAMI, Takuya, IWAUCHI, Megumi, MOGAMI, Shinpei, and HIRONAKA, Shouji

Subjects
digestive, oral, and skin physiology
Abstract

A Special Needs Dental Center （hereafter referred to as the Center） was established at Showa University Dental Hospital in April 2012 to treat patients who need special care. In cooperation with the Division of Dentistry for Persons with Disabilities, the Division of Hygiene and Oral Health is mainly engaged in the treatment of patients with eating and swallowing disorders. It has been five years since the establishment of the Center. The present study was aimed to establish an effective medical support method through a comparative study of changes in patient trends. A total of 65 patients who visited the Center from April 2017 to March 2018 were examined and their statistics were compared with those of 60 previously reported patients who initially visited the Center for medical examination in 2012. In 2012, many visits occurred during the nursing period; however, in 2017, the number of patients who visited after the weaning period increased. Other noted trends were increased diversity in primary disease, more patient referrals, fewer patients with severe swallowing dysfunction, and more patients with oral dysfunction. The necessity of eating and swallowing practice is thought to increase when lifestyle and oral environment change. The treatment of eating and swallowing disorders is important in the dental profession. Due to the introduction of insurance coverage in Japan in 2018 for developmental insufficiency of oral function, more pediatric patients with eating and swallowing disorders will likely be treated in the future.

Published
2019

9. Increased expression of L‐plastin in nasal polyp of patients with nonsteroidal anti‐inflammatory drug‐exacerbated respiratory disease

Author

Takabayashi, Tetsuji, primary, Tanaka, Yukie, additional, Susuki, Dai, additional, Yoshida, Kanako, additional, Tomita, Kaori, additional, Sakashita, Masafumi, additional, Imoto, Yoshimasa, additional, Kato, Yukinori, additional, Narita, Norihiko, additional, Nakayama, Tsugihisa, additional, Haruna, Shinichi, additional, Schleimer, Robert P., additional, and Fujieda, Shigeharu, additional

Published
2018
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10. Clinical Statistics for Dysphagia Patients ≦ 18 Years of Age in the Center of Special Needs Dentistry, April 2012-March 2013

Author

OGAWA, Ayano, ISHIKAWA, Toshikazu, MORITA, Yu, ISHIKAWA, Kentaro, WATANABE, Masahiro, OOKA, Takafumi, UTSUMI, Akemi, KUBOTA, Kazumi, TOMITA, Kaori, TAKAHASHI, Mari, ISHIZAKI, Akiko, ISHIDA, Keigo, MURAKAMI, Kohji, TAKAGI, Daisuke, OSAKABE, Luna, ASAMI, Takuya, EBUCHI, Asari, MUKAI, Yoshiharu, and HIRONAKA, Shouji

Abstract

In April 2012, the Center of Special Needs Dentistry (SND) was established at Showa University Dental Hospital to provide function training for children with eating and swallowing disorders. A statistical clinical assessment was performed on new patients ≤18 years of age who visited the Center over a 1-year period (April 2012–March 2013) to assess the conditions present at the initial visit. In all, 60 patients (29 boys, 31 girls, mean (± SD) age 4.2±4.1 years, range 0-18 years of age) were included in the study. Most patients were

Published
2015

12. Increased expression of L‐plastin in nasal polyp of patients with nonsteroidal anti‐inflammatory drug‐exacerbated respiratory disease.

Author

Takabayashi, Tetsuji, Tanaka, Yukie, Susuki, Dai, Yoshida, Kanako, Tomita, Kaori, Sakashita, Masafumi, Imoto, Yoshimasa, Kato, Yukinori, Narita, Norihiko, Nakayama, Tsugihisa, Haruna, Shinichi, Schleimer, Robert P., and Fujieda, Shigeharu

Subjects
NASAL polyps, RESPIRATORY diseases, MACROPHAGE colony-stimulating factor, FIBRIN, ASPIRIN, CYCLOOXYGENASE inhibitors, CELL membranes
Abstract

Background: Most patients with nonsteroidal anti‐inflammatory drug‐exacerbated respiratory disease (NERD) suffer from recurrence of nasal polyps. However, little is known about the specific cellular and molecular mechanisms contributing to the pathogenesis of nasal polyp development in patients with NERD in particular, especially at baseline when cyclooxygenase 1 inhibitors are not present. The objectives of this study were to identify proteins involved in the pathogenesis of nasal polyps in patients with NERD. Methods: We collected nasal polyp tissue from patients with NERD and from patients with aspirin‐tolerant chronic rhinosinusitis with nasal polyps (CRSwNP). Protein profiles were analyzed by 2‐dimensional electrophoresis and identified several proteins, including L‐plastin, as highly expressed. We examined L‐plastin and tissue factor (TF) expression by immunohistochemical and immunofluorescence analyses. To examine the role of L‐plastin in eosinophils, we knocked down L‐plastin expression in Eol‐1 cells by using siRNA transfection. Results: L‐plastin protein levels in nasal polyp tissue were increased in patients with NERD relative to those in patients with aspirin tolerant CRSwNP. Immunofluorescence analysis revealed that L‐plastin was dominantly expressed in eosinophils and L‐plastin and TF were co‐expressed in eosinophils in NERD nasal polyp tissue. Knockdown of L‐plastin in Eol‐1 cells disrupted the cell surface distribution of TF by stimulation with granulocyte macrophage colony‐stimulating factor. Conclusion: Increased expression of L‐plastin by eosinophils may contribute to abnormal fibrin deposition through TF translocation to the eosinophil cell surface in NERD nasal polyp tissue, which in turn may contribute to the pathogenesis of NERD. [ABSTRACT FROM AUTHOR]

Published
2019
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13. Clinical Statistics for Dysphagia Patients ≤18 Years of Age in the Center of Special Needs Dentistry, April 2012–March 2013

Author

OGAWA, Ayano, primary, ISHIKAWA, Toshikazu, additional, MORITA, Yu, additional, ISHIKAWA, Kentaro, additional, WATANABE, Masahiro, additional, OOKA, Takafumi, additional, UTSUMI, Akemi, additional, KUBOTA, Kazumi, additional, TOMITA, Kaori, additional, TAKAHASHI, Mari, additional, ISHIZAKI, Akiko, additional, ISHIDA, Keigo, additional, MURAKAMI, Kohji, additional, TAKAGI, Daisuke, additional, OSAKABE, Luna, additional, ASAMI, Takuya, additional, EBUCHI, Asari, additional, MUKAI, Yoshiharu, additional, and HIRONAKA, Shouji, additional

Published
2015
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15. Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population

Author

Hirota, Tomomitsu, primary, Takahashi, Atsushi, additional, Kubo, Michiaki, additional, Tsunoda, Tatsuhiko, additional, Tomita, Kaori, additional, Sakashita, Masafumi, additional, Yamada, Takechiyo, additional, Fujieda, Shigeharu, additional, Tanaka, Shota, additional, Doi, Satoru, additional, Miyatake, Akihiko, additional, Enomoto, Tadao, additional, Nishiyama, Chiharu, additional, Nakano, Nobuhiro, additional, Maeda, Keiko, additional, Okumura, Ko, additional, Ogawa, Hideoki, additional, Ikeda, Shigaku, additional, Noguchi, Emiko, additional, Sakamoto, Tohru, additional, Hizawa, Nobuyuki, additional, Ebe, Koji, additional, Saeki, Hidehisa, additional, Sasaki, Takashi, additional, Ebihara, Tamotsu, additional, Amagai, Masayuki, additional, Takeuchi, Satoshi, additional, Furue, Masutaka, additional, Nakamura, Yusuke, additional, and Tamari, Mayumi, additional

Published
2012
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16. ORAI1 Genetic Polymorphisms Associated with the Susceptibility of Atopic Dermatitis in Japanese and Taiwanese Populations

Author

Chang, Wei-Chiao, primary, Lee, Chih-Hung, additional, Hirota, Tomomitsu, additional, Wang, Li-Fang, additional, Doi, Satoru, additional, Miyatake, Akihiko, additional, Enomoto, Tadao, additional, Tomita, Kaori, additional, Sakashita, Masafumi, additional, Yamada, Takechiyo, additional, Fujieda, Shigeharu, additional, Ebe, Koji, additional, Saeki, Hidehisa, additional, Takeuchi, Satoshi, additional, Furue, Masutaka, additional, Chen, Wei-Chiao, additional, Chiu, Yi-Ching, additional, Chang, Wei Pin, additional, Hong, Chien-Hui, additional, Hsi, Edward, additional, Juo, Suh-Hang Hank, additional, Yu, Hsin-Su, additional, Nakamura, Yusuke, additional, and Tamari, Mayumi, additional

Published
2012
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18. Variants of C-C Motif Chemokine 22 (CCL22) Are Associated with Susceptibility to Atopic Dermatitis: Case-Control Studies

Author

Hirota, Tomomitsu, primary, Saeki, Hidehisa, additional, Tomita, Kaori, additional, Tanaka, Shota, additional, Ebe, Kouji, additional, Sakashita, Masafumi, additional, Yamada, Takechiyo, additional, Fujieda, Shigeharu, additional, Miyatake, Akihiko, additional, Doi, Satoru, additional, Enomoto, Tadao, additional, Hizawa, Nobuyuki, additional, Sakamoto, Tohru, additional, Masuko, Hironori, additional, Sasaki, Takashi, additional, Ebihara, Tamotsu, additional, Amagai, Masayuki, additional, Esaki, Hitokazu, additional, Takeuchi, Satoshi, additional, Furue, Masutaka, additional, Noguchi, Emiko, additional, Kamatani, Naoyuki, additional, Nakamura, Yusuke, additional, Kubo, Michiaki, additional, and Tamari, Mayumi, additional

Published
2011
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19. Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

Author

Hirota, Tomomitsu, primary, Takahashi, Atsushi, additional, Kubo, Michiaki, additional, Tsunoda, Tatsuhiko, additional, Tomita, Kaori, additional, Doi, Satoru, additional, Fujita, Kimie, additional, Miyatake, Akihiko, additional, Enomoto, Tadao, additional, Miyagawa, Takehiko, additional, Adachi, Mitsuru, additional, Tanaka, Hiroshi, additional, Niimi, Akio, additional, Matsumoto, Hisako, additional, Ito, Isao, additional, Masuko, Hironori, additional, Sakamoto, Tohru, additional, Hizawa, Nobuyuki, additional, Taniguchi, Masami, additional, Lima, John J, additional, Irvin, Charles G, additional, Peters, Stephen P, additional, Himes, Blanca E, additional, Litonjua, Augusto A, additional, Tantisira, Kelan G, additional, Weiss, Scott T, additional, Kamatani, Naoyuki, additional, Nakamura, Yusuke, additional, and Tamari, Mayumi, additional

Published
2011
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21. Total synthesis of xanthanolides

Author

Matsuo, Kazumasa, primary, Ohtsuki, Keiko, additional, Yoshikawa, Takashi, additional, Shishido, Kozo, additional, Yokotani-Tomita, Kaori, additional, and Shindo, Mitsuru, additional

Published
2010
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29. ORAI1 Genetic Polymorphisms Associated with the Susceptibility of Atopic Dermatitis in Japanese and Taiwanese Populations.

Author

Wei-Chiao Chang, Chih-Hung Lee, Tomomitsu Hirota, Li-Fang Wang, Satoru Doi, Miyatake, Akihiko, Enomoto, Tadao, Tomita, Kaori, Sakashita, Masafumi, Yamada, Takechiyo, Fujieda, Shigeharu, Ebe, Koji, Saeki, Hidehisa, Takeuchi, Satoshi, Masutaka Furue, Wei-Chiao Chen, Yi-Ching Chiu, Wei Pin Chang, Chien-Hui Hong, and Edward Hsi

Subjects
ATOPIC dermatitis, SKIN inflammation, SINGLE nucleotide polymorphisms, GENETIC polymorphisms
Abstract

Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD patients and 1027 control subject from Japanese population for sequencing and genotyping ORAI1. A total of 14 genetic variants including 3 novel single-nucleotide polymorphisms (SNPs) in the ORAI1 gene were identified. Our results indicated that a non-synonymous SNP (rs3741596, Ser218Gly) associated with the susceptibility of AD in the Japanese population but not in the Taiwanese population. However, there is another SNP of ORAI1 (rs3741595) associated with the risk of AD in the Taiwanese population but not in the Japanese population. Taken together, our results indicated that genetic polymorphisms of ORAI1 are very likely to be involved in the susceptibility of AD. [ABSTRACT FROM AUTHOR]

Published
2012
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34. Light-induced auxin-inhibiting substance from cabbage ( Brassica oleaceaL.) shoots

Author

Kosemura, Seiji, Niwa, Kazuki, Emori, Hideyuki, Yokotani-Tomita, Kaori, Hasegawa, Koji, and Yamamura, Shosuke

Abstract

A light-induced auxin-inhibitory substance, indolylacetonitrile (IAN), was isolated from light-grown cabbage ( Brassica oleareaL.) shoots. The IAN content in cabbage shoots increased in response to light. Cabbage hypocotyl elongation is inhibited by 10 −5M of IAN in 90 min but promoted after 48 hr. Light-induced growth inhibition is caused by the degradation of 3-indolylmethylglucosnolathe (IMG) to IAN which is, in turn, converted to the growth hormone indole-3-acetic acid (IAA).

Published
1997
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38. DL-α-Tocopherol acetate mitigates maternal hyperthermia-induced pre-implantation embryonic death accompanied by a reduction of physiological oxidative stress in mice.

Author

Sakamoto, Natsumi, Ozawa, Manabu, Yokotani-Tomita, Kaori, Morimoto, Aki, Matsuzuka, Takaya, Ijiri, Daichi, Hirabayashi, Miho, Ushitani, Atsuko, and Kanai, Yukio

Subjects
VITAMIN E, EMBRYOS, MICE, OXIDATIVE stress, PHYSIOLOGICAL effects of heat
Abstract

Maternal hyperthermia induces pre-implantation embryo death, which is accompanied by enhanced physiological oxidative stress. We evaluated whether the administration of DL-α-tocopherol acetate (TA) to hyperthermic mothers mitigated pre-implantation embryo death. Mice were exposed to heat stress (35 °C, 60% relative humidity) for 12 h or not heated (25 °C) on the day of mating. Twelve hours before the beginning of temperature treatment, TA was injected intraperitoneally at a dose of 1 g/kg body weight. After the treatment, zygotes were recovered and the developmental abilities and intracellular glutathione (GSH) levels were evaluated. Another set of mice, with or without TA treatment, was exposed to heat stress for 12, 24 and 36 h, and the urinary levels of the oxidative stress marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured. Heat stress significantly decreased the blastocyst development rate and the GSH content in zygotes, as compared with the non-heat-stressed embryos, while TA administration significantly mitigated the deleterious effects of heat stress with regard to both parameters. Moreover, although the urinary levels of 8-OHdG gradually increased according to the duration of heat exposure, with or without TA administration, the levels were lower in the TA-administered group than in the placebo-injected mice. These results suggest that heat stress enhances physiological oxidative stress, and that TA administration alleviates the hyperthermia-induced death of pre-implantation embryos by reducing physiological oxidative stress. [ABSTRACT FROM AUTHOR]

Published
2008
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39. [Eosinophilic chronic rhinosinusitis].

Author

Fujieda S, Sakashita M, Tokunaga T, Okano M, Haruna T, Yoshikawa M, Ohtori N, Asaka D, Haruna S, Nakayama T, Ishitoya J, Sakuma Y, Hirakawa K, Takeno S, Himi T, Seki N, Iino Y, Yoshida N, Kobayashi M, Sakaida H, Kondo K, Yamasoba T, Miwa T, Yamada K, Kawata R, Terada T, Kawauchi H, Morikura I, Ikeda K, Murata J, Ikeda H, Noguchi E, Tamari M, Hirota T, Imoto Y, Takabayashi T, Tomita K, Ninomiya T, Morikawa T, and Urashima M

Subjects
Algorithms, Chronic Disease, Humans, Recurrence, Rhinitis diagnosis, Rhinitis therapy, Sinusitis diagnosis, Sinusitis therapy, Eosinophils immunology, Rhinitis immunology, Sinusitis immunology
Published
2015

41. DL-alpha-tocopherol acetate mitigates maternal hyperthermia-induced pre-implantation embryonic death accompanied by a reduction of physiological oxidative stress in mice.

Author

Sakamoto N, Ozawa M, Yokotani-Tomita K, Morimoto A, Matsuzuka T, Ijiri D, Hirabayashi M, Ushitani A, and Kanai Y

Subjects
8-Hydroxy-2'-Deoxyguanosine, Animals, Biomarkers urine, Deoxyguanosine analogs & derivatives, Deoxyguanosine urine, Embryo Loss metabolism, Female, Fever metabolism, Glutathione analysis, Mice, Mice, Inbred Strains, Oxidative Stress, Pregnancy, Pregnancy Complications metabolism, Time Factors, Tocopherols, Zygote drug effects, Zygote metabolism, alpha-Tocopherol therapeutic use, Antioxidants therapeutic use, Embryo Loss prevention & control, Fever drug therapy, Pregnancy Complications drug therapy, alpha-Tocopherol analogs & derivatives
Abstract

Maternal hyperthermia induces pre-implantation embryo death, which is accompanied by enhanced physiological oxidative stress. We evaluated whether the administration of DL-alpha-tocopherol acetate (TA) to hyperthermic mothers mitigated pre-implantation embryo death. Mice were exposed to heat stress (35 degrees C, 60% relative humidity) for 12 h or not heated (25 degrees C) on the day of mating. Twelve hours before the beginning of temperature treatment, TA was injected intraperitoneally at a dose of 1 g/kg body weight. After the treatment, zygotes were recovered and the developmental abilities and intracellular glutathione (GSH) levels were evaluated. Another set of mice, with or without TA treatment, was exposed to heat stress for 12, 24 and 36 h, and the urinary levels of the oxidative stress marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured. Heat stress significantly decreased the blastocyst development rate and the GSH content in zygotes, as compared with the non-heat-stressed embryos, while TA administration significantly mitigated the deleterious effects of heat stress with regard to both parameters. Moreover, although the urinary levels of 8-OHdG gradually increased according to the duration of heat exposure, with or without TA administration, the levels were lower in the TA-administered group than in the placebo-injected mice. These results suggest that heat stress enhances physiological oxidative stress, and that TA administration alleviates the hyperthermia-induced death of pre-implantation embryos by reducing physiological oxidative stress.

Published
2008
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