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2. Allosteric binding properties of a 1,3-alternate thiacalix[4]arene-based receptor having phenylthiourea and 2-pyridylmethyl moieties on opposite faces

Author

Rahman, S, Tomiyasu, H, Wang, CZ, Georghiou, PE, Alodhayb, A, Carpenter-Warren, CL, Elsegood, MRJ, Teat, SJ, Redshaw, C, and Yamato, T

Subjects
Networking and Information Technology R&D, General Chemistry, Chemical Sciences
Abstract

The synthesis of three new heteroditopic receptors (5a-c) which are based on thiacalix[4]arenes in the 1,3-alternate conformation is reported herein. These new receptors each have two thiourea moieties linking phenyl groups, two of which are substituted with electron-withdrawing groups at their para-positions, and at the opposite side of the thiacalix[4]arene cavity, with two 2-pyridylmethyl groups. One example (5a) was also characterized by X-ray crystallography. A limited 1H-NMR and UV-vis anion complexation study was conducted. DFT computational determinations indicated that 5c, which has strongly electron-withdrawing NO2 groups, had the most effective recognition ability towards the selected anions. The binding of Ag+ at the 2-pyridyl moieties, and the binding of the anions at the two thiourea NH groups of the p-substituted phenylthioureido moieties, respectively, was also investigated. The appearance of a positive allosteric effect with receptor 5b was also found using 1H-NMR titration experiments.

Published
2021

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