1. Effect of reproductive ageing on pregnant mouse uterus and cervix
- Author
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Patel, Rima, Moffatt, James D., Mourmoura, Evangelia, Demaison, Luc, Seed, Paul T., Poston, Lucilla, Tribe, Rachel M., Division of Women's Health, King‘s College London, St Thomas' Hospital, Division of Biomedical Sciences, St. George’s Hospital University, Laboratoire de Bioénergétique Fondamentale et Appliquée, Université Joseph Fourier - Grenoble 1 (UJF), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), BBSRC PhD studentship (BB/G017190/1 ), Tommy's charity 1060508, Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Clermont Université-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Recherche Agronomique (INRA), and Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université
- Subjects
0301 basic medicine ,Male ,modèle animal ,Aging ,Muscle Physiology ,Physiology ,Uterus ,Ageing and Degeneration ,souris ,Oxytocin ,Uterine contraction ,smooth muscle ,Fathers ,Mice ,Uterine Contraction ,0302 clinical medicine ,Reproductive Physiology ,Pregnancy ,Oxytocics ,Medicine ,Progesterone ,030219 obstetrics & reproductive medicine ,myometrium ,Myometrium ,animal models ,mitochondria ,medicine.anatomical_structure ,facteur de risque ,risk factor ,maternal age ,parturition ,Gestation ,Muscle ,Matrix Metalloproteinase 2 ,Female ,Collagen ,medicine.symptom ,Research Paper ,Perspectives ,medicine.medical_specialty ,Médecine humaine et pathologie ,grossesse ,DNA, Mitochondrial ,Andrology ,effet de l'âge ,03 medical and health sciences ,Internal medicine ,cervix ,Tensile Strength ,[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,Humans ,Animals ,Advanced maternal age ,maternité ,Cervix ,Physiologie ,business.industry ,motherhood ,Parturition ,medicine.disease ,Oxytocin receptor ,Mice, Inbred C57BL ,030104 developmental biology ,Endocrinology ,Human health and pathology ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Key points Older pregnant women have a greater risk of operative delivery, still birth and post‐term induction.This suggests that maternal age can influence the timing of birth and processes of parturition.We have found that increasing maternal age in C57BL/6J mice is associated with prolongation of gestation and length of labour.Older pregnant mice also had delayed progesterone withdrawal and impaired myometrial function.Uterine ageing and labour dysfunction should be investigated further in older primigravid women. Abstract Advanced maternal age (≥35 years) is associated with increased rates of operative delivery, stillbirth and post‐term labour induction. The physiological causes remain uncertain, although impaired myometrial function has been implicated. To investigate the hypothesis that maternal age directly influences successful parturition, we assessed the timing of birth and fetal outcome in pregnant C57BL/6J mice at 3 months (young) and 5 months (intermediate) vs. 8 months (older) of age using infrared video recording. Serum progesterone profiles, myometrium and cervix function, and mitochondrial electron transport chain complex enzymatic activities were also examined. Older pregnant mice had a longer mean gestation and labour duration (P, Key points Older pregnant women have a greater risk of operative delivery, still birth and post‐term induction.This suggests that maternal age can influence the timing of birth and processes of parturition.We have found that increasing maternal age in C57BL/6J mice is associated with prolongation of gestation and length of labour.Older pregnant mice also had delayed progesterone withdrawal and impaired myometrial function.Uterine ageing and labour dysfunction should be investigated further in older primigravid women.
- Published
- 2016