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9 results on '"Tomohiro Oiwa"'

3. Role of Prostaglandin E-Major Urinary Metabolite Levels in Identifying the Phenotype of Pachydermoperiostosis

Author

Mami Ishibashi, Tomohiro Oiwa, Takashi Nomura, Hironori Niizeki, Yoshiaki Yoshikawa, and Kenji Kabashima

Subjects
Adult, Male, Adolescent, Osteoarthropathy, Primary Hypertrophic, medicine.medical_treatment, Metabolite, Urinary system, Organic Anion Transporters, Dermatology, Pharmacology, Biochemistry, Young Adult, chemistry.chemical_compound, Text mining, Humans, Medicine, Molecular Biology, Alleles, business.industry, Prostaglandins E, Prostanoic Acids, Cell Biology, Middle Aged, Hand, Phenotype, chemistry, Case-Control Studies, Mutation, Hydroxyprostaglandin Dehydrogenases, business, Biomarkers, Prostaglandin E
Published
2021

5. Eicosanoid profiling in patients with complete form of pachydermoperiostosis carrying SLCO2A1 mutations

Author

Hironori Niizeki, Takehiko Yokomizo, Feras M. Ghazawi, Toshiaki Okuno, Mai Ohba, Yuichiro Endo, Kenji Kabashima, Tomohiro Oiwa, Ryuji Uozumi, Mami Ishibashi, Kazue Yoshida, and Takashi Nomura

Subjects
medicine.medical_specialty, Osteoarthropathy, Primary Hypertrophic, Prostaglandin, Organic Anion Transporters, Dermatology, Dinoprostone, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Medicine, Humans, SLCO2A1, biology, business.industry, General Medicine, biology.organism_classification, Eicosapentaenoic acid, Endocrinology, chemistry, Pachydermia, Eicosanoid, Docosahexaenoic acid, 030220 oncology & carcinogenesis, Mutation, biology.protein, Eicosanoids, lipids (amino acids, peptides, and proteins), Arachidonic acid, business, Homeostasis
Abstract

Pachydermoperiostosis (PDP) is a genetic disease characterized by digital clubbing, periostosis, and pachydermia caused by mutated HPGD or SLCO2A1. Plasma prostaglandin (PG)E2 levels are increased in these patients. However, other eicosanoids have not been quantitated. We aimed to quantitate plasma eicosanoid levels in four patients carrying SLCO2A1 mutations by high-performance liquid chromatography-tandem mass spectrometry. PGE2 level was elevated in all patients; PGD2 and 11β-PGF2 α levels were also increased in some patients, whereas eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels were decreased in all patients. Our data indicate a dysfunctional eicosanoid homeostasis and varied levels of PG in patients with a complete form of PDP carrying SLCO2A1 mutations. PGE2 levels seem to mostly affect the symptoms, with other eicosanoids possibly having a minor effect.

Published
2021

6. A Case of Ixekizumab-induced Psoriasiform Eruption

Author

Takao Tachibana, Tomohiro Oiwa, Kayo Okada, Sawako Takase, Miyuki Ota, Youichi Nishimura, and Mafumi Fujita

Subjects
Male, Clobetasol, medicine.medical_specialty, business.industry, Biopsy, Dermatology, General Medicine, Antibodies, Monoclonal, Humanized, Psoriasiform eruption, Ixekizumab, Treatment Outcome, RL1-803, Humans, Psoriasis, Medicine, Dermatologic Agents, Drug Eruptions, business, Glucocorticoids, Aged, Skin
Published
2019

7. A Case of Subcutaneous Infection with Mycobacterium mageritense Identified by Matrix-assisted Laser Desorption/Ionization-time of Flight Mass Spectrometry

Author

Tetsuya Honda, Satoshi Nakano, Tomohiro Oiwa, Kenji Kabashima, and Teruasa Murata

Subjects
Male, Mycobacterium Infections, Chromatography, biology, business.industry, Matrix assisted laser desorption ionization time of flight, Skin Diseases, Bacterial, Dermatology, General Medicine, lcsh:RL1-803, Mass spectrometry, Mycobacterium mageritense, biology.organism_classification, Mycobacterium, Matrix-assisted laser desorption/ionization, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, lcsh:Dermatology, Humans, Medicine, business, Aged
Published
2018

8. Three cases of facial erythema with dryness and pruritus in psoriasis patients during treatment with IL-17 inhibitors

Author

Atsushi Otsuka, Tetsuya Honda, Tomohiro Oiwa, and Kenji Kabashima

Subjects
0301 basic medicine, medicine.medical_specialty, business.industry, Dermatology, medicine.disease, 030207 dermatology & venereal diseases, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Infectious Diseases, Psoriasis, medicine, Dryness, Facial erythema, Interleukin 17, medicine.symptom, business
Published
2017

9. Fabrication of IGZO and In2O3-channel Ferroelectric-gate Thin Film Transistors

Author

Tomohiro Oiwa and Eisuke Tokumitsu

Subjects
Fabrication, Materials science, Subthreshold conduction, business.industry, Transistor, Ferroelectricity, law.invention, Hysteresis, law, Thin-film transistor, Optoelectronics, Thin film, business, Communication channel
Abstract

We have fabricated and characterized ferroelectric-gate TFTs using In-Ga-Zn-O (IGZO) or In2O3 as a channel material. The ferroelectric gate insulator used in this work is (Bi,La)4Ti3O12 (BLT). We observed normal n-channel transistor operation for both IGZO and In2O3-channel TFTs. However, a charge injection type hysteresis was observed for IGZO channel TFTs in drain current – gate voltage (ID-VG) characteristics. Post fabrication anneal at 300oC reduced the charge-injection-tyoe hystereesis and the subthreshold swing was also improved from 0.27 to 0.19 V/decade. On the other hand, when the In2O3 was used as a channel, hysteresis due to the ferroelectric gate insulator was clearly observed in ID-VG characteristics. A memory window of 2V, a subthreshold voltage swing of 0.35V/decade, a field-effect mobility of 1.6 cm2/Vs, and a on/off drain current ratio of more than 10^6 were obtained.

Published
2010

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