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3. Minimally Invasive Mitral Valve Surgery in Elderly Patients: Results from a Multicenter Study

Author

Francica, A, Barbero, C, Tonelli, F, Cerillo, A, Lodo, V, Centofanti, P, Marchetto, G, Di Credico, G, De Paulis, R, Stefano, P, Luciani, G, Onorati, F, Rinaldi, M, Francica, Alessandra, Barbero, Cristina, Tonelli, Filippo, Cerillo, Alfredo Giuseppe, Lodo, Vittoria, Centofanti, Paolo, Marchetto, Giovanni, Di Credico, Germano, De Paulis, Ruggero, Stefano, Pierluigi, Luciani, Giovanni Battista, Onorati, Francesco, Rinaldi, Mauro, Francica, A, Barbero, C, Tonelli, F, Cerillo, A, Lodo, V, Centofanti, P, Marchetto, G, Di Credico, G, De Paulis, R, Stefano, P, Luciani, G, Onorati, F, Rinaldi, M, Francica, Alessandra, Barbero, Cristina, Tonelli, Filippo, Cerillo, Alfredo Giuseppe, Lodo, Vittoria, Centofanti, Paolo, Marchetto, Giovanni, Di Credico, Germano, De Paulis, Ruggero, Stefano, Pierluigi, Luciani, Giovanni Battista, Onorati, Francesco, and Rinaldi, Mauro

Abstract

Background: Minimally invasive mitral valve surgery (MIMVS) has been increasingly adopted worldwide as an alternative to conventional sternotomy, especially for young patients. The remarkable results gained by MIMVS have encouraged its application in more complex and fragile patients, such as the elderly, though results in this subgroup remain controversial. It is the aim of this study to assess the postoperative outcomes of patients older than 75 years old undergoing MIMVS, and to compare these results to those of younger patients. Methods: The data of all patients undergoing MIMVS between 2015 and 2022 were retrospectively collected at seven high-volume cardiac surgery centers. Patients were divided into two age-based groups: the young (<65 years old) and the elderly (>75 years old). A propensity score (PS) matching analysis obtained two comparable groups. Postoperative outcomes were assessed in both the unmatched and PS-matched populations. Results: Out of 1113 patients undergoing MIMVS, 524 were young and 279 were elderly. Elderly patients were more commonly affected by multiple comorbidities, with a higher EuroSCORE II (4.6 ± 5.5% vs. 1.6 ± 3.3%, p < 0.001). There was no difference in postoperative mortality, though the elderly had a greater incidence of postoperative complications, such as re-exploration for bleeding, stroke, reintubation, and a need for hemodialysis and blood transfusions. After PS matching, 119 pairs of young and elderly patients with similar risk profiles (EuroSCORE II 2.5 ± 4.7% vs. 2.7 ± 3.2%, p = 0.7) were compared, and no differences in all postoperative outcomes were found. Conclusions: Adequately selected elderly patients can report hospital outcomes similar to young patients after MIMVS.

Published
2024

8. Stress and mental health of COVID-19 survivors and their families after hospital discharge: relationship with perceived healthcare staff empathy

Author

Bassi, Marco, Carissoli, Claudia, Tonelli, F., Trombetta, L., Magenta, M., Delle Fave, A., Cogliati, C., Bassi M., Carissoli C. (ORCID:0000-0003-1456-8740), Bassi, Marco, Carissoli, Claudia, Tonelli, F., Trombetta, L., Magenta, M., Delle Fave, A., Cogliati, C., Bassi M., and Carissoli C. (ORCID:0000-0003-1456-8740)

Abstract

Several studies attest to the long-term consequences of COVID-19 infection on survivors’ mental illness, especially in terms of high prevalence of post-traumatic stress disorder (PTSD) 1–3 months after hospitalization. Aims of the present study were (1) to jointly evaluate PTSD and positive mental health among COVID-19 survivors and family members after hospital discharge, and (2) to investigate the relationship between perceived healthcare staff’s relational empathy during hospitalization and survivors’ post-traumatic stress levels. In this cross-sectional study, 60 survivors (Mage = 60.45; 63.3% men) and 40 family members (Mage = 52.33; 60% women) participated in an online survey 3–7 months after hospital discharge. In addition to providing socio-demographic data, they completed PTSD Checklist for DSM-5 and Mental Health Continuum Short Form. Survivors also completed the Consultation and Relational Empathy measure. Percentages of participants meeting a provisional PTSD and mental health diagnosis (flourishing, moderate, languishing) were calculated. A hierarchical regression analysis was performed on survivors’ data, with perceived staff’s empathy as predictor and post-traumatic stress symptoms (PTSS) as outcome. One-fifth of the participants received a provisional PTSD diagnosis, about half were diagnosed with flourishing or moderate mental health, and only 5% were languishing, with no significant between-group differences. Among survivors, a negative association was detected between perceived healthcare staff’s empathy and PTSS, explaining 10.5% of the model variance over and above demographic and clinical variables. Findings highlighted the coexistence of PTSD and positive mental health among survivors and family members, suggesting the usefulness of assessing both negative and positive dimensions of mental health, in order to promote psycho-social adaptation once returning to everyday life. In addition, the role of compassionate c

Published
2023

9. PC.01.9 HYPOMETHYLATION OF LINE-1 IN SMALL BOWEL CARCINOMAS AND COELIAC DISEASE

Author

Guerini, C., primary, Bianchi, P.I., additional, Libera, L., additional, Vanoli, A., additional, Arpa, G., additional, Aronico, N., additional, Furlan, D., additional, Grillo, F., additional, Nesi, G., additional, Sampietro, G., additional, Ardizzone, S., additional, Fociani, P., additional, Fiocca, R., additional, Latella, G., additional, Sessa, F., additional, D'Errico, A., additional, Malvi, D., additional, Mescoli, C., additional, Rugge, M., additional, Ferrero, S., additional, Poggioli, G., additional, Rizzello, F., additional, Macciomei, M., additional, Santini, D., additional, Volta, U., additional, De Giorgio, R., additional, Caio, G., additional, Calabro, A., additional, Ciacci, C., additional, D'Armiento, M., additional, Rizzo, A., additional, Solina, G., additional, Tonelli, F., additional, Villanacci, V., additional, Cannizzaro, R., additional, Canzonieri, V., additional, Florena, A., additional, Biancone, L., additional, Monteleone, G., additional, Caronna, R., additional, Ciardi, A., additional, Elli, L., additional, Caprioli, F., additional, Vecchi, M., additional, D'Inca, R., additional, Zingone, F., additional, D'Odorico, A., additional, Oreggia, B., additional, Reggiani Bonetti, L., additional, Astegiano, M., additional, Cantoro, L., additional, Papi, C., additional, Sandri, G., additional, Silano, M., additional, Usai, P., additional, Perfetti, V., additional, Quaquarini, E., additional, Giannone, A., additional, Orlandi, A., additional, Barresi, V., additional, Ciccocioppo, R., additional, Amodeo, G., additional, Biletta, E., additional, and Di Sabatino, A., additional

Published
2023
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18. P301 Non-familial small bowel carcinomas in Crohnʼs disease: clinico-pathological, molecular and prognostic features

Author

Di Sabatino, A., Vanoli, A., Furlan, D., Giuffrida, P., Klersy, C., Grillo, F., Fiocca, R., Mescoli, C., Rugge, M., Nesi, G., Fociani, P., Sampietro, G., Ardizzone, S., Luinetti, O., Calabrò, A., Tonelli, F., Volta, U., Santini, D., Caio, G., Elli, L., Ferrero, S., Latella, G., Ciardi, A., Solina, G., Rizzo, A., Ciacci, C., DʼArmiento, F.P., Salemme, M., Villanacci, V., Cannizzaro, R., Canzonieri, V., Reggiani Bonetti, L., Biancone, L., Monteleone, G., Orlandi, A., Santeusanio, G., Macciomei, M.C., DʼIncà, R., Perfetti, V., Sandri, G., Silano, M., Florena, A.M., Giannone, A.G., Papi, C., Coppola, L., Usai, P., Maccioni, A., Astegiano, M., Migliora, P., Manca, R., Martino, M., Trapani, D., Cerutti, R., Alberizzi, P., Riboni, R., Sessa, F., Paulli, M., Solcia, E., and Corazza, G.R.

Published
2017
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22. Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype

Author

Tonelli, F, primary, Cotti, S, additional, Leoni, L, additional, Besio, R, additional, Gioia, R, additional, Marchese, L, additional, Giorgetti, S, additional, Villani, S, additional, Gistelinck, C, additional, Wagener, R, additional, Kobbe, B, additional, Fiedler, I A K, additional, Larionova, D, additional, Busse, B, additional, Eyre, D, additional, Rossi, A, additional, Witten, P E, additional, and Forlino, A, additional

Published
2021
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24. Transforming growth factor (beta) signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures

Author

Di Sabatino, A., Jackson, C.l., Pickard, K.M., Buckley, M., Rovedatti, L., Leakey, N.A.B., Picariello, L., Cazzola, P., Monteleone, G., Tonelli, F., Corazza, G.R., MacDonald, T.T., and Pender, S.L.

Subjects
Crohn's disease -- Development and progression, Crohn's disease -- Research, Transforming growth factors -- Physiological aspects, Transforming growth factors -- Research, Cellular signal transduction -- Physiological aspects, Cellular signal transduction -- Research, Metalloproteins -- Physiological aspects, Metalloproteins -- Research, Cystic fibrosis -- Development and progression, Cystic fibrosis -- Research, Health
Published
2009

25. Anastomotic leaks after anterior resection for mid and low rectal cancer: survey of the Italian Society of Colorectal Surgery

Author

Asteria, C. R., Gagliardi, G., Pucciarelli, S., Romano, G., Infantino, A., La Torre, F., Tonelli, F., Martin, F., Pulica, C., Ripetti, V., Diana, G., Amicucci, G., Carlini, M., Sommariva, A., Vinciguerra, G., Poddie, D. B., Amato, A., Bassi, R., Galleano, R., Veronese, E., Mancini, S., Pescio, G., Occelli, G. L., Bracchitta, S., Castagnola, M., Pontillo, T., Cimmino, G., Prati, U., and Vincenti, R.

Published
2008
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27. CXCR3 and (alpha sub E beta sub 7) integrin identify a subset of CD8+ mature thymocytes that share phenotypic and functional properties with CD8+ gut intraepithelial lymphocytes

Author

Annunziato, F., Cosmi, L., Liotta, F., Lazzeri, E., Ramagnani, P., Angeli, R., Lasagni, L., Manetti, R., Marra, F., Gerard, C., Petrai, I., Dello Sbarba, P., Tonelli, F., Maggi, E., and Romagnani, S.

Subjects
CD8 lymphocytes -- Research, Integrins -- Research, Gastrointestinal mucosa -- Physiological aspects, Gastrointestinal mucosa -- Research, Health
Published
2006

28. Phytoestrogens and Colon Cancer

Author

Pampaloni, B., primary, Mavilia, C., additional, Bartolini, E., additional, Tonelli, F., additional, Brandi, M.L., additional, and DAst, Federica, additional

Published
2013
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33. Correction: PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability (Modern Pathology, (2020), 33, 7, (1398-1409), 10.1038/s41379-020-0497-0)

Author

Giuffrida, P., Arpa, G., Grillo, F., Klersy, C., Sampietro, G., Ardizzone, S., Fociani, P., Fiocca, R., Latella, G., Sessa, F., D'Errico, A., Malvi, D., Mescoli, C., Rugge, M., Nesi, G., Ferrero, S., Furlan, D., Poggioli, G., Rizzello, F., Macciomei, M. C., Santini, D., Volta, U., De Giorgio, R., Caio, G., Calabro, A., Ciacci, C., D'Armiento, M., Rizzo, A., Solina, G., Martino, M., Tonelli, F., Villanacci, V., Cannizzaro, R., Canzonieri, V., Florena, A. M., Biancone, L., Monteleone, G., Caronna, R., Ciardi, A., Elli, L., Caprioli, F., Vecchi, M., D'Inca, R., Zingone, F., D'Odorico, A., Lenti, M. V., Oreggia, B., Bonetti, L. R., Astegiano, M., Biletta, E., Cantoro, L., Giannone, A. G., Orlandi, A., Papi, C., Perfetti, V., Quaquarini, E., Sandri, G., Silano, M., Usai, P., Barresi, V., Ciccocioppo, R., Luinetti, O., Pedrazzoli, P., Pietrabissa, A., Viglio, A., Paulli, M., Corazza, G. R., Solcia, E., Vanoli, A., and Di Sabatino, A.

Published
2020

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