435 results on '"Tonelli R."'
Search Results
2. Manoeuvring experiments, mathematical model and sensitivity analysis for test-case ferry
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Ferrari, V., primary, Tonelli, R., additional, Kisjes, A.S., additional, and Hallmann, R., additional
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- 2022
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3. An investigation on the heel influence on manoeuverability: A twin-screw RORO vessel case study
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Piaggio, B., primary, Rimini, B., additional, Villa, D., additional, Viviani, M., additional, Ferrari, V., additional, and Tonelli, R., additional
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- 2022
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4. Higher Blood Eosinophil Count Is Associated With Increased Likelihood of Asthma Exacerbation With COVID-19 Infection
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Ayache, M., primary and Tonelli, R., additional
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- 2024
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5. Prevalence and development of chronic critical illness in acute patients admitted to a respiratory intensive care setting
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Marchioni, A., Tonelli, R., Sdanganelli, A., Gozzi, F., Musarò, L., Fantini, R., Tabbì, L., Andreani, A., Cappiello, G., Costi, S., Castaniere, I., and Clini, E.
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- 2020
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6. Respiratory Mechanics and Diaphragmatic Dysfunction in COPD Patients Who Failed Non-Invasive Mechanical Ventilation
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Marchioni A, Tonelli R, Fantini R, Tabbì L, Castaniere I, Livrieri F, Bedogni S, Ruggieri V, Pisani L, Nava S, and Clini E
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acute exacerbation of copd ,non-invasive mechanical ventilation ,respiratory failure ,transdiaphragmatic pressure. ,Diseases of the respiratory system ,RC705-779 - Abstract
Alessandro Marchioni,1 Roberto Tonelli,1,2 Riccardo Fantini,1 Luca Tabbì,1 Ivana Castaniere,1,2 Francesco Livrieri,1,3 Sabrina Bedogni,4 Valentina Ruggieri,1 Lara Pisani,5 Stefano Nava,5 Enrico Clini1 1University Hospital of Modena, Pneumology Unit and Center for Rare Lung Diseases, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2PhD Course in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italy; 3Respiratory Disease Unit, Hospital Carlo Poma, Mantova, Italy; 4School of Medicine, University of Modena and Reggio Emilia, Modena, Italy; 5Department of Specialistic, Diagnostic and Experimental Medicine (DIMES), University of Bologna, Bologna, ItalyCorrespondence: Roberto TonelliUniversity Hospital of Modena, Pneumology Unit and Center for Rare Lung Diseases, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Via del Pozzo, 71 – 41125, Modena, ItalyTel +39-342-7241672Email roberto.tonelli@me.com Skype roberto.tonelli150288Background: Although non-invasive mechanical ventilation (NIV) is the gold standard treatment for patients with acute exacerbation of COPD (AECOPD) developing respiratory acidosis, failure rates still range from 5% to 40%. Recent studies have shown that the onset of severe diaphragmatic dysfunction (DD) during AECOPD increases risk of NIV failure and mortality in this subset of patients. Although the imbalance between the load and the contractile capacity of inspiratory muscles seems the main cause of AECOPD-induced hypercapnic respiratory failure, data regarding the influence of mechanical derangement on DD in this acute phase are lacking. With this study, we investigate the impact of respiratory mechanics on diaphragm function in AECOPD patients experiencing NIV failure.Methods: Twelve AECOPD patients with respiratory acidosis admitted to the Respiratory ICU of the University Hospital of Modena from 2017 to 2018 undergoing mechanical ventilation (MV) due to NIV failure were enrolled. Static respiratory mechanics and end-expiratory lung volume (EELV) were measured after 30 mins of volume control mode MV. Subsequently, transdiaphragmatic pressure (Pdi) was calculated by means of a sniff maneuver (Pdisniff) after 30 mins of spontaneous breathing trial. Linear regression analysis and Pearson’s correlation coefficient served to assess associations.Results: Average Pdisniff was 23.3 cmH2O (standard deviation 29 cmH2O) with 3 patients presenting bilateral diaphragm palsy. Pdisniff was directly correlated with static lung elastance (r=0.69, p=0.001) while inverse correlation was found with dynamic intrinsic PEEP (r=−0.73, p=0.007). No significant correlation was found with static intrinsic PEEP (r=−0.55, p=0.06), EELV (r=−0.4, p=0.3), airway resistance (r=−0.2, p=0.54), chest wall, and total elastance (r=−0-01, p=0.96 and r=0.3, p=0.36, respectively). Significant linear inverse correlation was found between Pdisniff and the ratio between Pdi assessed at tidal volume and Pdi sniff (r=−0.82, p=0.02).Conclusion: The causes of extreme DD in AECOPD patients who experienced NIV failure might be predominantly mechanical, driven by a severe dynamic hyperinflation that overlaps on an elastic lung substrate favoring volume overload.Keywords: acute exacerbation of COPD, non-invasive mechanical ventilation, respiratory failure, transdiaphragmatic pressure
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- 2019
7. Fibonacci-like sequences and shift spaces in symbolic dynamics
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Tonelli, R.
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Mathematics - Dynamical Systems ,05-(C38,A15), 11B-(37, 39, 50), 37B-(10, 40, 50), 62-(P35, D05) - Abstract
We afford the problem of counting the blocks of a given length made with symbols drawn from an alphabet and relate this number to Fibonacci-like recurrent relations. The recurrence polynomia allows to calculate the limit ratio of two adjacent terms and this information is used to determine the topological entropy of a discrete numbers of associate shift spaces. We then describe a scheme to build a shift space with a pre-selected entropy.
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- 2007
8. Numerical Study of the Oscillatory Convergence to the Attractor at the Edge of Chaos
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Tonelli, R. and Coraddu, M.
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Condensed Matter - Statistical Mechanics - Abstract
This paper compares three different types of ``onset of chaos'' in the logistic and generalized logistic map: the Feigenbaum attractor at the end of the period doubling bifurcations; the tangent bifurcation at the border of the period three window; the transition to chaos in the generalized logistic with inflection 1/2 ($x_{n+1} = \mu x_{n}^{1/2}$), in which the main bifurcation cascade, as well as the bifurcations generated by the periodic windows in the chaotic region, collapse in a single point. The occupation number and the Tsallis entropy are studied. The different regimes of convergence to the attractor, starting from two kinds of far-from-equilibrium initial conditions, are distinguished by the presence or absence of log-log oscillations, by different power-law scalings and by a gap in the saturation levels. We show that the escort distribution implicit in the Tsallis entropy may tune the log-log oscillations or the crossover times., Comment: 10 pages, 5 figures
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- 2005
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9. Convergence to the Critical Attractor at Infinite and Tangent Bifurcation Points
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Tonelli, R.
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Nonlinear Sciences - Chaotic Dynamics - Abstract
The dynamics of the convergence to the critical attractor for the logistic map is investigated. At the border of chaos, when the Liapunov exponent is zero, the use of the non-extensive statistical mechanics formalism allows to define a weak sensitivity or insensitivity to initial conditions. Using this formalism we analyse how a set of initial conditions spread all over the phase space converges to the critical attractor in the case of infinite bifurcation and tangent bifurcation points. We show that the phenomena is governed in both cases by a power-law regime but the critical exponents depend on the type of bifurcation and may also depend on the numerical experiment set-up. Differences and similarities between the two cases are also discussed., Comment: 5 figures, accepted for publication in Int. J. of Bifurcation and Chaos (July 2006)
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- 2005
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10. Weak insensitivity to initial conditions at the edge of chaos in the logistic map
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Coraddu, M., Meloni, F., Mezzorani, G., and Tonelli, R.
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Condensed Matter - Statistical Mechanics - Abstract
We extend existing studies of weakly sensitive points within the framework of Tsallis non-extensive thermodynamics to include weakly insensitive points at the edge of chaos. Analyzing tangent points of the logistic map we have verified that the generalized entropy with suitable entropic index q correctly describes the approach to the attractor., Comment: 6 pages, 3 figures
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- 2004
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11. Association between respiratory distress time and invasive mechanical ventilation in COVID-19 patients: A multicentre regional cohort study
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Busani, S., Coloretti, I., Baciarello, M., Bellini, V., Sarti, M., Biagioni, E., Tonelli, R., Marchioni, A., Clini, E., Guaraldi, G., Mussini, C., Meschiari, M., Tonetti, T., Pisani, L., Nava, S., Bignami, E., Ranieri, M.V., and Girardis, M.
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- 2024
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12. Prevalence of asthma and COPD in a cohort of patients at the follow up after COVID-19 pneumonia
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Verduri, A., primary, Hewitt, J., additional, Carter, B., additional, Tonelli, R., additional, Clini, E., additional, and Beghè, B., additional
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- 2023
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13. Accuracy of Nasal Pressure Swing to Predict Failure of High Flow Nasal Oxygen in Patients With Acute Hypoxemic Respiratory Failure
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Bruzzi, G., primary, Tonelli, R., additional, Cortegiani, A., additional, Fantini, R., additional, Tabbì, L., additional, Castaniere, I., additional, Manicardi, L., additional, Moretti, A., additional, Cerbone, C., additional, Gozzi, F., additional, Andrisani, D., additional, Baroncini, S., additional, Busani, S., additional, Ball, L., additional, Clini, E., additional, and Marchioni, A., additional
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- 2023
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14. Towards a Scalable Dual-Sided Blockchain Architecture with Concurrency Protocols
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Nazir, A., primary, Singh, M., additional, Destefanis, G., additional, Kassab, M., additional, Memon, J., additional, Neykova, R., additional, and Tonelli, R., additional
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- 2023
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15. An Optimized Concurrent Proof of Authority Consensus Protocol
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Nazir, A., primary, Singh, M., additional, Destefanis, G., additional, Memon, J., additional, Neykova, R., additional, Kassab, M., additional, and Tonelli, R., additional
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- 2023
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16. Smart contract metrics: a first study
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Tonelli, R, Pierro, GA, Ortu, M, and Destefanis, G
- Abstract
R.T. and A.P. were funded by the Italian Ministry of University and Research (MUR): MUR 4 - Public research - PRIN 2020 cup F73C22000430001 and by Fondazione Di Sardegna, 2020/22, F72F20000190007; M.O. was funded by the Italian Ministry of University and Research (MUR) CUP: PE00000018.
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- 2023
17. The heel influence on ship manoeuvrability: Single and twin-screw surface vessels
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Piaggio, B., primary, Franceschi, A., additional, Villa, D., additional, Ferrari, V., additional, Tonelli, R., additional, and Viviani, M., additional
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- 2022
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18. Differences between acute exacerbations of idiopathic pulmonary fibrosis and other interstitial lung diseases
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Faverio, P, Stainer, A, Conti, S, Madotto, F, De Giacomi, F, Zoppa, M, Vancheri, A, Pellegrino, M, Tonelli, R, Cerri, S, Clini, E, Mantovani, L, Pesci, A, Luppi, F, Faverio P., Stainer A., Conti S., Madotto F., De Giacomi F., Zoppa M. D., Vancheri A., Pellegrino M. R., Tonelli R., Cerri S., Clini E. M., Mantovani L. G., Pesci A., Luppi F., Faverio, P, Stainer, A, Conti, S, Madotto, F, De Giacomi, F, Zoppa, M, Vancheri, A, Pellegrino, M, Tonelli, R, Cerri, S, Clini, E, Mantovani, L, Pesci, A, Luppi, F, Faverio P., Stainer A., Conti S., Madotto F., De Giacomi F., Zoppa M. D., Vancheri A., Pellegrino M. R., Tonelli R., Cerri S., Clini E. M., Mantovani L. G., Pesci A., and Luppi F.
- Abstract
Interstitial lung diseases (ILDs) comprise a wide group of pulmonary parenchymal disorders. These patients may experience acute respiratory deteriorations of their respiratory condition, termed “acute exacerbation” (AE). The incidence of AE-ILD seems to be lower than idiopathic pulmonary fibrosis (IPF), but prognosis and prognostic factors are largely unrecognized. We retrospectively analyzed a cohort of 158 consecutive adult patients hospitalized for AE-ILD in two Italian university hospitals from 2009 to 2016. Patients included in the analysis were divided into two groups: non-IPF (62%) and IPF (38%). Among ILDs included in the non-IPF group, the most frequent diagnoses were non-specific interstitial pneumonia (NSIP) (42%) and connective tissue disease (CTD)-ILD (20%). Mortality during hospitalization was significantly different between the two groups: 19% in the non-IPF group and 43% in the IPF group. AEs of ILDs are difficult-to-predict events and are burdened by relevant mortality. Increased inflammatory markers, such as neutrophilia on the differential blood cell count (HR 1.02 (CI 1.01–1.04)), the presence of pulmonary hypertension (HR 1.85 (CI 1.17–2.92)), and the diagnosis of IPF (HR 2.31 (CI 1.55–3.46)), resulted in negative prognostic factors in our analysis. Otherwise, lymphocytosis on the differential count seemed to act as a protective prognostic factor (OR 0.938 (CI 0.884–0.995)). Further prospective, large-scale, real-world data are needed to support and confirm the impact of our findings.
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- 2021
19. The fractal dimension of software networks as a global quality metric
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Turnu, I., Concas, G., Marchesi, M., and Tonelli, R.
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- 2013
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20. Ventilatory support and mechanical properties of the fibrotic lung acting as a “squishy ball”
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Marchioni, A, Tonelli, R, Rossi, G, Spagnolo, P, Luppi, F, Cerri, S, Cocconcelli, E, Pellegrino, M, Fantini, R, Tabbi, L, Castaniere, I, Ball, L, Malbrain, M, Pelosi, P, Clini, E, Marchioni A., Tonelli R., Rossi G., Spagnolo P., Luppi F., Cerri S., Cocconcelli E., Pellegrino M. R., Fantini R., Tabbi L., Castaniere I., Ball L., Malbrain M. L. N. G., Pelosi P., Clini E., Marchioni, A, Tonelli, R, Rossi, G, Spagnolo, P, Luppi, F, Cerri, S, Cocconcelli, E, Pellegrino, M, Fantini, R, Tabbi, L, Castaniere, I, Ball, L, Malbrain, M, Pelosi, P, Clini, E, Marchioni A., Tonelli R., Rossi G., Spagnolo P., Luppi F., Cerri S., Cocconcelli E., Pellegrino M. R., Fantini R., Tabbi L., Castaniere I., Ball L., Malbrain M. L. N. G., Pelosi P., and Clini E.
- Abstract
Protective ventilation is the cornerstone of treatment of patients with the acute respiratory distress syndrome (ARDS); however, no studies have yet established the best ventilatory strategy to adopt when patients with acute exacerbation of interstitial lung disease (AE-ILD) are admitted to the intensive care unit. Due to the severe impairment of the respiratory mechanics, the fibrotic lung is at high risk of developing ventilator-induced lung injury, regardless of the lung fibrosis etiology. The purpose of this review is to analyze the effects of mechanical ventilation in AE-ILD and to increase the knowledge on the characteristics of fibrotic lung during artificial ventilation, introducing the concept of “squishy ball lung”. The role of positive end-expiratory pressure is discussed, proposing a “lung resting strategy” as opposed to the “open lung approach”. The review also discusses the practical management of AE-ILD patients discussing illustrative clinical cases.
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- 2020
21. Erratum: Acute exacerbation of interstitial lung diseases secondary to systemic rheumatic diseases: A prospective study and review of the literature (Journal of Thoracic Disease (2019) 11 (1621-1628) DOI: 10.21037/jtd.2019.03.28)
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Manfredi A., Manfredi, A, Sebastiani, M, Cerri, S, Vacchi, C, Tonelli, R, Della Casa, G, Cassone, G, Spinella, A, Pancaldi, F, Luppi, F, Salvarani, C, Manfredi A., Sebastiani M., Cerri S., Vacchi C., Tonelli R., Della Casa G., Cassone G., Spinella A., Pancaldi F., Luppi F., Salvarani C., Manfredi A., Manfredi, A, Sebastiani, M, Cerri, S, Vacchi, C, Tonelli, R, Della Casa, G, Cassone, G, Spinella, A, Pancaldi, F, Luppi, F, Salvarani, C, Manfredi A., Sebastiani M., Cerri S., Vacchi C., Tonelli R., Della Casa G., Cassone G., Spinella A., Pancaldi F., Luppi F., and Salvarani C.
- Abstract
In the article that appeared on Page 1621-1628, Vol 11, No 4 (April 2019) Issue of the Journal of Thoracic Disease (1), the given and family names of author “Fabrizio Pancaldi” was incorrectly published in the original. The author's name should be corrected as Fabrizio Pancaldi, instead of Pancaldi Fabrizio. The authors regret the error.
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- 2020
22. Hypokalemia in Patients with COVID-19
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Alfano, G., Ferrari, A., Fontana, F., Perrone, R., Mori, G., Ascione, E., Magistroni, R., Venturi, G., Pederzoli, S., Margiotta, G., Romeo, M., Piccinini, F., Franceschi, G., Volpi, S., Faltoni, M., Ciusa, G., Bacca, E., Tutone, M., Raimondi, A., Menozzi, M., Franceschini, E., Cuomo, G., Orlando, G., Santoro, A., Di Gaetano, M., Puzzolante, C., Carli, F., Bedini, A., Milic, J., Meschiari, M., Mussini, C., Cappelli, G., Guaraldi, G., Borghi, V., Burastero, G., Corradi, L., Dolci, G., Fantini, R., Iadisernia, V., Larne, D., Pellegrino, F., Rogati, C., Tonelli, R., Yaacoub, D., Alfan, S., Marco, B., Pulizzi, R., Leonelli, M., Facchini, F., Damiano, F., Girardis, M., Andreotti, A., Biagioni, E., Bondi, F., Busani, S., Chierego, G., Scotti, M., Cossarizza, L. S. A., Bellinazzi, C., Borella, R., De Biasi, S., De Gaetano, A., Fidanza, L., Gibellini, L., Iannone, A., Tartaro, D. L., Mattioli, M., Nasi, M., Paolini, A., and Pinti, M.
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Male ,Pediatrics ,Physiology ,medicine.medical_treatment ,030232 urology & nephrology ,Urine ,030204 cardiovascular system & hematology ,Electrolytes ,0302 clinical medicine ,Risk Factors ,80 and over ,Prevalence ,Medicine ,Magnesium ,Hospital Mortality ,Diuretics ,COVID ,Aged, 80 and over ,Urinary potassium loss ,Middle Aged ,Hypokalemia ,Nephrology ,Cohort ,Original Article ,Female ,SOFA score ,medicine.symptom ,Coronavirus ,Potassium ,Aged ,COVID-19 ,Humans ,Retrospective Studies ,SARS-CoV-2 ,Electrolyte Disorder ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Anorexia ,03 medical and health sciences ,Physiology (medical) ,Internal medicine ,Hyperventilation ,In patient ,business.industry ,Retrospective cohort study ,Odds ratio ,Diuretic ,business - Abstract
Patients with COVID-19 may experience multiple conditions (e.g., fever, hyperventilation, anorexia, gastroenteritis, acid-base disorder) that may cause electrolyte imbalances. Hypokalemia is a concerning electrolyte disorder that may increase the susceptibility to various kinds of arrhythmia. This study aimed to estimate prevalence, risk factors and outcome of hypokalemia in a cohort of non-critically ill patients. A retrospective analysis was conducted on 290 hospitalized patients with confirmed COVID-19 infection at the tertiary teaching hospital of Modena, Italy.Hypokalemia (Hypokalemia is a frequent disorder in COVID-19 patients and urinary potassium loss may be the main cause of hypokalemia. The disorder was mild in the majority of the patients and was unrelated to poor outcomes. Nevertheless, hypokalemic patients required potassium supplements to dampen the risk of arrhythmias.
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- 2021
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23. An investigation on the heel influence on manoeuverability: A twin-screw RORO vessel case study
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Piaggio, B., Rimini, B., Villa, D., Viviani, M., Ferrari, V., and Tonelli, R.
- Subjects
heel effect ,Manoeuvrability, heel effect, mathematical models, RORO ferry, stability code ,RORO ferry ,Manoeuvrability ,stability code ,mathematical models - Published
- 2022
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24. Prokineticin receptor identified by phage display is an entry receptor for Trypanosoma cruzi into mammalian cells
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Khusal, K. G., Tonelli, R. R., Mattos, E. C., Soares, C. O., Di Genova, B. M., Juliano, M. A., Urias, U., Colli, W., and Alves, M. J. M.
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- 2015
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25. Nasal Pressure Swings as the Measure of Inspiratory Effort in Spontaneously Breathing Patients with De Novo Acute Respiratory Failure
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Tonelli, R., primary, Ball, L., additional, Cortegiani, A., additional, Marchioni, A., additional, Fantini, R., additional, Tabbì, L., additional, Castaniere, I., additional, Manicardi, L., additional, Bruzzi, G., additional, Andrisani, D., additional, Gozzi, F., additional, Busani, S., additional, Girardis, M., additional, Gregoretti, C., additional, Pelosi, P., additional, and Clini, E., additional
- Published
- 2022
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26. Comorbidity and Mortality of Pasteurella Disease in a Safety Net Hospital
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Khalid, F., primary, Tonelli, R., additional, and Kourouni, I., additional
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- 2022
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27. Measurement and QCD analysis of double-differential inclusive jet cross sections in proton-proton collisions at root s=13 TeV
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Tumasyan, A., Adam, W., Rejkovic, J. W., Bergauer, T., Chatterjee, S., Damanakis, K., Dragicevic, M., Escalante Del Valle, Fruhwirth, A., Jeitler, R., Krammer, M., Lechner, N., Liko, L., Mikulec, D., Paulitsch, I., Pitters, P., Schieck, F. M., Schofbeck, J., Schwarz, R., Templ, D., Waltenberger, S., Wulz, W., C. -E., Chekhovsky, V., Litomin, A., Makarenko, V., Darwish, M. R., Wolf, De, Janssen, E. A., Kello, T., Lelek, T., Rejeb, Sfar, Van, Mechelen, Van, Putte, Van, Remortel, Blekman, N., Bols, F., D'Hondt, E. S., Delcourt, J., Faham, El, Lowette, H., Moortgat, S., Morton, S., Muller, A., Sahasransu, D., Tavernier, A. R., Van, Doninck, Beghin, W., Bilin, D., Clerbaux, B., Lentdecker, De, Favart, G., Grebenyuk, L., Kalsi, A., Lee, A. K., Mahdavikhorrami, K., Makarenko, M., Moureaux, I., Petre, L., Popov, L., Postiau, A., Starling, N., Thomas, E., L. V., Bemden, En, M. V., Velde, Er, Vanlaer, C., Cornelis, P., Dobur, T., Knolle, D., Lambrecht, J., Mestdach, L., Niedziela, G., Roskas, M., Samalan, C., Skovpen, A., Tytgat, K., Vermassen, M., Wezenbeek, B., Benecke, L., Bethani, A., Bruno, A., Bury, G., Caputo, F., David, C., Delaere, P., Donertas, C., Giammanco, I. S., Jaffel, A., Jain, K., Lemaitre, Sa., Mondal, V., Prisci, K., Aro, J., Taliercio, A., Teklishyn, M., Tran, T. T., Vischia, P., Wertz, S., Alves, G. A., Hensel, C., Moraes, A., Alda, Junior, W. L., Alves Gallo Pereira, Barroso Ferreira Filho, Br, M., Malbouisson, Ao, Carvalho, H., Chinellato, W., Costa, Da, E. M., Silveira, Da, G. G., De Jesus Damiao, Fonseca De Souza, Mora, Herrera, Mota, Amarilo, Mundim, K., Nogima, L., Rebello, Teles, Santoro, P., Silva Do Amaral, Sznajder, S. M., Thiel, A., Torres Da Silva De Araujo, Vilela, Pereira, Bernardes, A., Calligaris, C. A., Fern, L., ez Perez Tomei, Gregores, T. R., Lemos, E. M., Mercadante, D. S., Novaes, P. G., Padula, S. F., S, Ra, S., Aleks, Rov, Antchev, A., Hadjiiska, G., Iaydjiev, R., Misheva, P., Rodozov, M., Shopova, M., Sultanov, M., Dimitrov, G., Ivanov, A., Litov, T., Pavlov, L., Petkov, B., Petrov, P., Cheng, A., Javaid, T., Mittal, T., Yuan, M., Ahmad, L., Bauer, M., Dozen, G., Hu, C., Martins, Z., Wang, J., Yi, Y., Chapon, K., Chen, E., Chen, G. M., Chen, H. S., Iemmi, M., Kapoor, F., Leggat, A., Liao, D., Liu, H., Z. -A., Milosevic, V., Monti, F., Sharma, R., Tao, J., Thomas-Wilsker, J., Zhang, H., Zhao, J., Agapitos, A., An, Y., Ban, Y., Chen, C., Levin, A., Li, Q., Lyu, X., Mao, Y., Qian, S. J., Wang, D., Wang, Q., Xiao, J., Lu, M., You, Z., Gao, X., Okawa, H., Zhang, Y., Lin, Z., Xiao, M., Avila, C., Cabrera, A., Florez, C., Fraga, J., Mejia, Guisao, Ramirez, J., Ruiz, Alvarez, J. D., Salazar, Gonzalez, Giljanovic, C. A., Godinovic, D., Lelas, N., Puljak, D., Antunovic, I., Kovac, Z., Sculac, M., Brigljevic, T., Ferencek, V., Majumder, D., Roguljic, D., Starodumov, M., Susa, A., Attikis, T., Christoforou, A., Erodotou, K., Ioannou, E., Kole, A., Kolosova, G., Konstantinou, M., Mousa, S., Nicolaou, J., Ptochos, C., Razis, F., Rykaczewski, P. A., Saka, H., Finger, H., Finger, M., r. M., J, Kveton, A., Ayala, E., Carrera, Jarrin, Assran, E., Ellithi, Kamel, Mahmoud, A., Mohammed, M. A., Bhowmik, Y., Dewanjee, S., Ehataht, R. K., Kadastik, K., M. N., An, S., Nielsen, C., Pata, J., Raidal, M., Tani, L., Veelken, C., Eerola, P., Forthomme, L., Kirschenmann, H., Osterberg, K., Voutilainen, M., Bharthuar, S., Brucken, E., Garcia, F., Havukainen, J., Kim, M. S., Kinnunen, R., Lampen, T., Lassila-Perini, K., Lehti, S., Linden, T., Lotti, M., Martikainen, L., Myllymaki, M., Ott, J., Siikonen, H., Tuominen, E., Tuominiemi, J., Luukka, P., Petrow, H., Tuuva, T., Amendola, C., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Faure, J. L., Ferri, F., Ganjour, S., Gras, P., Hamel de Monchenault, Jarry, G., Lenzi, P., Locci, B., Malcles, E., J. R., Er, J., Rosowsky, A., Sahin, M. O., Savoy-Navarro, A., Titov, M., G. B., Yu, Ahuja, S., Beaudette, F., Bonanomi, M., Buchot, Perraguin, Busson, A., Cappati, P., Charlot, A., Davignon, C., Diab, O., Falmagne, B., Ghosh, G., Granier de Cassagnac, Hakimi, R., Kucher, A., Motta, I., Nguyen, J., Och, M., O, C., Paganini, P., Rembser, J., Salerno, R., Sarkar, U., Sauvan, J. B., Sirois, Y., Tarabini, A., Zabi, A., Zghiche, A., Agram, J. -L., Rea, J., Apparu, D., Bloch, D., Bourgatte, G., Brom, J. -M., Chabert, E. 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H., Trembath-Reichert, D., Vetens, S., Cms, Collaboration, Damarseçkin, Serdal, CMS Collaboration, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), CMS, Tumasyan, A, Adam, W, Andrejkovic, JW, Bergauer, T, Chatterjee, S, Damanakis, K, Dragicevic, M, Del Valle, AE, Fruhwirth, R, Jeitler, M, Krammer, N, Lechner, L, Liko, D, Mikulec, I, Paulitsch, P, Pitters, FM, Schieck, J, Schofbeck, R, Schwarz, D, Templ, S, Waltenberger, W, Wulz, CE, Chekhovsky, V, Litomin, A, Makarenko, V, Darwish, MR, De Wolf, EA, Janssen, T, Kello, T, Lelek, A, Sfar, HR, Van Mechelen, P, Van Putte, S, Van Remortel, N, Blekman, F, Bols, ES, D'Hondt, J, Delcourt, M, El Faham, H, Lowette, S, Moortgat, S, Morton, A, Muller, D, Sahasransu, AR, Tavernier, S, Van Doninck, W, Beghin, D, Bilin, B, Clerbaux, B, De Lentdecker, G, Favart, L, 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University, Kafkas University, Istanbul Bilgi University, Hacettepe University, Faculty of Engineering, University of Southampton, IPPP Durham University, Bethel University, Karamanoğlu Mehmetbey University, Ain Shams University, Bingol University, Sinop University, Erciyes University, Texas A&M University at Qatar, Università di Trento, CERN, Andrejkovic, J, Escalante Del Valle, A, Pitters, F, Wulz, C, Darwish, M, De Wolf, E, Rejeb Sfar, H, Bols, E, Sahasransu, A, Kalsi, A, Donertas, I, Tran, T, Alves, G, Alda Junior, W, Alves Gallo Pereira, M, Barroso Ferreira Filho, M, Brandao Malbouisson, H, Da Costa, E, Da Silveira, G, De Jesus Damiao, D, Fonseca De Souza, S, Mora Herrera, C, Mota Amarilo, K, Rebello Teles, P, Silva Do Amaral, S, Torres Da Silva De Araujo, F, Vilela Pereira, A, Bernardes, C, Fernandez Perez Tomei, T, Gregores, E, Lemos, D, Mercadante, P, Novaes, S, Padula, S, Chen, G, Chen, H, Liu, Z, Qian, S, Mejia Guisao, J, Ruiz Alvarez, J, Salazar Gonzalez, C, Razis, P, Carrera Jarrin, E, Ellithi Kamel, A, Mahmoud, M, Dewanjee, R, Faure, J, Hamel de Monchenault, G, Sahin, M, Yu, G, Buchot Perraguin, A, Granier de Cassagnac, R, Sauvan, J, Agram, J, Brom, J, Chabert, E, Fontaine, J, Le Bihan, A, Laktineh, I, Schuler, S, Haj Ahmad, W, Aarup Petersen, H, Aldaya Martin, M, Bermudez Martinez, A, Bin Anuar, A, Consuegra Rodriguez, S, Correia Silva, G, Estevez Banos, L, Jomhari, N, Melzer-Pellmann, I, Mendizabal Morentin, M, Perez Adan, D, Ribeiro Lopes, B, Sosa Ricardo, R, Pena Rodriguez, K, Gosewisch, J, Simonis, H, Von Cube, R, Koraka, C, Gadallah, M, Radl, A, Veres, G, Trocsanyi, Z, Komaragiri, J, Tiwari, P, Muraleedharan Nair Bindhu, V, Swain, S, Beri, S, Singh, J, Virdi, A, Choudhary, B, Rout, P, Behera, P, Behera, S, Pujahari, P, Sikdar, A, Mishra, D, Netrakanti, P, Pant, L, Etesami, S, Mohammadi Najafabadi, M, Simone, F, Cavallo, F, Dallavalle, G, Navarria, F, Siroli, G, Dinardo, M, Lucchini, M, Pinolini, B, Tabarelli de Fatis, T, Iorio, A, Hoh, S, Meneguzzo, A, Aime', C, Ratti, S, Bilei, G, Ciocci, M, Di Domenico, M, Matos Figueiredo, D, Roy Chowdhury, S, Verdini, P, Berenguer Antequera, J, Obertino, M, Pinna Angioni, G, Kim, G, Moon, C, Oh, Y, Pak, S, Radburn-Smith, B, Yang, Y, Moon, D, Kim, T, Park, S, Bhyun, J, Oh, B, Oh, S, Yang, U, Kang, D, Merlin, J, Park, I, Ryu, M, Watson, I, Yoo, H, Carvalho Antunes De Oliveira, A, Norjoharuddeen, N, Wan Abdullah, W, Yusli, M, Benitez, J, Castaneda Hernandez, A, Leon Coello, M, Murillo Quijada, J, Valencia Palomo, L, Mondragon Herrera, C, Perez Navarro, D, Sanchez Hernandez, A, Carrillo Moreno, S, Oropeza Barrera, C, Vazquez Valencia, F, Salazar Ibarguen, H, Uribe Estrada, C, Butler, P, Asghar, M, Awan, M, Hoorani, H, Khan, W, Shah, M, Yuldashev, B, Alcaraz Maestre, J, Alvarez Fernandez, A, Barrio Luna, M, Bedoya, C, Carrillo Montoya, C, Delgado Peris, A, Fernandez Ramos, J, Fouz, M, Gonzalez Lopez, O, Goy Lopez, S, Hernandez, J, Josa, M, Leon Holgado, J, Navarro Tobar, A, Perez Dengra, C, Perez-Calero Yzquierdo, A, Puerta Pelayo, J, Sanchez Navas, S, Urda Gomez, L, de Troconiz, J, Alvarez Gonzalez, B, Fernandez Menendez, J, Gonzalez Caballero, I, Gonzalez Fernandez, J, Palencia Cortezon, E, Ramon Alvarez, C, Rodriguez Bouza, V, Soto Rodriguez, A, Vico Villalba, C, Brochero Cifuentes, J, Cabrillo, I, Duarte Campderros, J, Fernandez Madrazo, C, Fernandez Manteca, P, Garcia Alonso, A, Martinez Rivero, C, Martinez Ruiz del Arbol, P, Matorras Cuevas, P, Piedra Gomez, J, Vizan Garcia, J, Jayananda, M, Sonnadara, D, Wickramarathna, D, Dharmaratna, W, Aarrestad, T, Capeans Garrido, M, Chhibra, S, D'Enterria, D, Defranchis, M, Marini, A, Reales Gutierrez, G, Tavolaro, V, Van Onsem, G, Wozniak, K, Zeuner, W, Kaestli, H, Gomez Espinosa, T, Lyon, A, Manzoni, R, Martin Perez, C, Meinhard, M, Ratti, M, Sanz Becerra, D, Zhu, D, Canelli, M, Heikkila, J, Liechti, S, Mikuni, V, Sanchez Cruz, S, Kuo, C, Yu, S, Chen, K, Chen, P, Hou, W, Li, Y, Lu, R, Wu, H, Yu, P, Demiroglu, Z, Gurpinar Guler, E, Kayis Topaksu, A, Simsek, A, Tok, U, Zorbakir, I, Atakisi, I, Yetkin, E, Sunar Cerci, D, Brooke, J, Heath, G, Heath, H, Seif El Nasr-Storey, S, Smith, V, Walkingshaw Pass, K, Bell, K, Brown, R, Cockerill, D, Ellis, K, Holmberg, M, Newbold, D, Shepherd-Themistocleous, C, Tomalin, I, Chahal, G, Hassanshahi, M, Magnan, A, Monk, D, Raymond, D, Webb, S, Cole, J, Reid, I, Kanuganti, A, Mcmaster, B, Vargas Hernandez, A, Cooper, S, Gleyzer, S, Perez, C, Hogan, J, Lau, K, Wong, W, Calderon De La Barca Sanchez, M, Cox, P, Iqbal, M, Nash, W, Gary, J, Long, O, Olmedo Negrete, M, Branson, J, Sathia Narayanan, B, Lawhorn, J, Newman, H, Nguyen, T, Vlimant, J, Zhu, R, Andrews, M, Cumalat, J, Ford, W, Macdonald, E, Ulmer, K, Wagner, S, Cranshaw, D, Patterson, J, Bauerdick, L, Bhat, P, Butler, J, Cerati, G, Cheung, H, Di Petrillo, K, Elvira, V, Harris, R, Herwig, T, Kwok, K, Mcbride, P, Reinsvold Hall, A, Spalding, W, Tran, N, Vaandering, E, Weber, H, Field, R, Joshi, B, Lo, K, Muthirakalayil Madhu, A, Johnson, K, Baarmand, M, Kumar Verma, R, Adams, M, Becerril Gonzalez, H, Gerber, C, Hangal, D, Hofman, D, Merrit, A, Tonjes, M, Gandrajula, R, Koseyan, O, Merlo, J, Gritsan, A, Vami, T, Baldenegro Barrera, C, Tapia Takaki, J, Eno, S, Hadley, N, Kellogg, R, Mignerey, A, Cali, I, Gomez Ceballos, G, Stephans, G, Chatterjee, R, Wadud, M, Claes, D, Siado, J, Snow, G, Zecchinelli, A, Mclean, C, Morse, D, Hahn, K, Schmitt, M, Hurtado Anampa, K, Mccauley, T, Zygala, B, Durkin, L, Nunez Ornelas, M, Winer, B, Yates, B, Addesa, F, Bakshi, A, Barnes, V, Jung, A, Schulte, J, Ecklund, K, Geurts, F, Padley, B, Stahl Leiton, A, Dulemba, J, Chou, J, Thayil, S, Delannoy, A, Arenton, M, Perez Lara, C, Madhusudanan Sreekala, J, Smith, W, Sağır, Sinan, Belforte, S., Candelise, V., Casarsa, M., Cossutti, F., DA ROLD, A., DELLA RICCA, G., Sorrentino, G., Vazzoler, F., and ET AL (the CMS, Collaboration)
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13000 GeV-cms ,Temel Bilimler (SCI) ,parton: distribution function ,transverse momentum [jet] ,PARTICLE PHYSICS ,LARGE HADRON COLLIDER ,CMS ,Physics, Particles & Fields ,rapidity dependence ,Hadron-Hadron Scattering ,Jet Physics ,effective field theory ,strong interaction: coupling constant ,scattering [p p] ,PROGRAM ,jet, production ,High energy physics ,Experimental particle physics ,LHC ,p p: scattering ,p p: colliding beams ,B: decay ,tau: hadronic decay ,interaction: gauge ,interaction: model ,transverse momentum: missing-energy ,new physics: search for ,mass spectrum: transverse ,black hole: quantum ,vector boson: mass ,W': leptonic decay ,sensitivity ,leptoquark: coupling ,CERN LHC Coll ,leptoquark: mass: lower limit ,anomaly ,channel cross section: upper limit ,Higgs ,Nuclear Experiment ,протон-протонные столкновения ,parton, distribution function ,двойные дифференциальные инклюзивные струи ,Physics ,QUARK ,perturbation theory: higher-order ,contact interaction ,PHYSICS, NUCLEAR ,2 [higher-order] ,higher-order, 2 ,higher-order, 1 ,track data analysis: jet ,Physical Sciences ,hadroproduction [jet] ,colliding beams [p p] ,distribution function [parton] ,coupling constant [strong interaction] ,1 [higher-order] ,p p, scattering ,strong interaction, coupling constant ,114 Physical sciences ,quark ,phase space ,FİZİK, NÜKLEER ,Z0, mass ,quantum chromodynamics ,strong coupling ,TeV ,ddc:530 ,0206 Quantum Physics ,Science & Technology ,higher-order [perturbation theory] ,jet: rapidity ,ATLAS, детектор ,Большой адронный коллайдер ,GeV ,jet: transverse momentum ,transverse momentum dependence ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,SINGLET ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,jet [track data analysis] ,0105 Mathematical Physics ,Temel Bilimler ,Wilson ,higher-order: 2 ,higher-order: 1 ,jet, rapidity ,Nuclear & Particles Physics ,Nükleer ve Yüksek Enerji Fiziği ,Natural Sciences (SCI) ,rapidity [jet] ,0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics ,Natural Sciences ,Particle Physics - Experiment ,perturbation theory [quantum chromodynamics] ,Nuclear and High Energy Physics ,data analysis method ,jet, transverse momentum ,FOS: Physical sciences ,Fizik ,PARTON DENSITIES ,COMPUTATION ,differential cross section: measured ,PHYSICS ,measured [differential cross section] ,quantum chromodynamics: perturbation theory ,hep-ex ,High Energy Physics::Phenomenology ,3-LOOP SPLITTING FUNCTIONS ,jet: hadroproduction ,EVOLUTION ,Physics and Astronomy ,Fizik Bilimleri ,High Energy Physics::Experiment ,experimental results - Abstract
A measurement of the inclusive jet production in proton-proton collisions at the LHC at √s = 13 TeV is presented. The double-differential cross sections are measured as a function of the jet transverse momentum pT and the absolute jet rapidity |y|. The anti-kT clustering algorithm is used with distance parameter of 0.4 (0.7) in a phase space region with jet pT from 97 GeV up to 3.1 TeV and |y| < 2.0. Data collected with the CMS detector are used, corresponding to an integrated luminosity of 36.3 fb−1 (33.5 fb−1). The measurement is used in a comprehensive QCD analysis at next-to-next-to-leading order, which results in significant improvement in the accuracy of the parton distributions in the proton. Simultaneously, the value of the strong coupling constant at the Z boson mass is extracted as αS(mZ) = 0.1170±0.0019. For the first time, these data are used in a standard model effective field theory analysis at next-to-leading order, where parton distributions and the QCD parameters are extracted simultaneously with imposed constraints on the Wilson coefficient c1 of 4-quark contact interactions., Individuals have received support from the Marie-Curie programme and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 724704, 752730, 758316, 765710, 824093, 884104, and COST Action CA16108 (European Union); the Leventis Foundation; the Alfred P. Sloan Foundation; the Alexander von Humboldt Foundation;the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the “Excellence of Science — EOS” — be.h project n. 30820817; the Beijing Municipal Science & Technology Commission, No. Z191100007219010; the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Deutsche Forschungsgemeinschaft (DFG), under Germany’s Excellence Strategy — EXC 2121 “Quantum Universe” — 390833306, and under project number 400140256 - GRK2497; the Lendület (“Momentum”) Programme and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences, the New National Excellence Program ÚNKP, the NKFIA research grants 123842, 123959, 124845, 124850, 125105, 128713, 128786, and 129058 (Hungary); the Council of Science and Industrial Research, India; the Latvian Council of Science; the Ministry of Science and Higher Education and the National Science Center, contracts Opus 2014/15/B/ST2/03998 and 2015/19/B/ST2/02861 (Poland); the Fundação para a Ciência e a Tecnologia, grant CEECIND/01334/2018 (Portugal); the National Priorities Research Program by Qatar National Research Fund; the Ministry of Science and Higher Education, projects no. 14.W03.31.0026 and no. FSWW-2020-0008, and the Russian Foundation for Basic Research, project No.19-42-703014 (Russia); the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2015-0509 and the Programa Severo Ochoa del Principado de Asturias; the Stavros Niarchos Foundation (Greece); the Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University and the Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); the Kavli Foundation; the Nvidia Corporation; the SuperMicro Corporation; the Welch Foundation, contract C-1845; and the Weston Havens Foundation (U.S.A.)., Article funded by SCOAP3.
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- 2022
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28. Correction: Endobronchial valve positioning for alveolar-pleural fistula following ICU management complicating COVID-19 pneumonia (BMC Pulmonary Medicine, (2021), 21, 1, (307), 10.1186/s12890-021-01653-w)
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Donatelli, P., Trentacosti, F., Pellegrino, M. R., Tonelli, R., Bruzzi, G., Andreani, A., Cappiello, G. F., Andrisani, D., Gozzi, F., Mussini, C., Busani, S., Cavaliere, G. V., Girardis, M., Bertellini, E., Clini, E., and Marchioni, A.
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- 2022
29. First and second wave among hospitalized COVID-19 patients with severe pneumonia: a comparison of 28-day mortality over 1-year pandemic in a tertiary university hospital in Italy
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Meschiari, M, Cozzi-Lepri, A, Tonelli, R, Bacca, E, Menozzi, M, Franceschini, E, Cuomo, G, Bedini, A, Volpi, S, Milic, J, Brugioni, L, Romagnoli, E, Pietrangelo, A, Corradini, E, Coloretti, I, Biagioni, E, Busani, S, Girardis, M, Cossarizza, A, Clini, E, Guaraldi, G, and Mussini, C.
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Thoracic medicine ,Epidemiology Infectitious diseases ,COVID-19 ,Respiratory infections ,COVID-19, Epidemiology Infectitious diseases, Respiratory infections, Thoracic medicine - Published
- 2022
30. Molecular mechanisms and cellular contribution from lung fibrosis to lung cancer development
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Samarelli AV, Masciale V, Aramini B, Coló GP, Tonelli R, Marchioni A, Bruzzi G, Gozzi F, Andrisani D, Castaniere I, Manicardi L, Moretti A, Tabbì L, Guaitoli G, Cerri S, Dominici M, Clini E., and Samarelli AV, Masciale V, Aramini B, Coló GP, Tonelli R, Marchioni A, Bruzzi G, Gozzi F, Andrisani D, Castaniere I, Manicardi L, Moretti A, Tabbì L, Guaitoli G, Cerri S, Dominici M, Clini E.
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Molecular mechanisms, lung fibrosis, lung cancer ,respiratory system ,respiratory tract diseases - Abstract
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of diagnosis. Although IPF has unknown aetiology by definition, there have been identified several risks factors increasing the probability of the onset and progression of the disease in IPF patients such as cigarette smoking and environmental risk factors associated with domestic and occupational exposure. Among them, cigarette smoking together with concomitant emphysema might predispose IPF patients to lung cancer (LC), mostly to non-small cell lung cancer (NSCLC), increasing the risk of lung cancer development. To this purpose, IPF and LC share several cellular and molecular processes driving the progression of both pathologies such as fibroblast transition proliferation and activation, endoplasmic reticulum stress, oxidative stress, and many genetic and epigenetic markers that predispose IPF patients to LC development. Nintedanib, a tyrosine–kinase inhibitor, was firstly developed as an anticancer drug and then recognized as an anti-fibrotic agent based on the common target molecular pathway. In this review our aim is to describe the updated studies on common cellular and molecular mechanisms between IPF and lung cancer, knowledge of which might help to find novel therapeutic targets for this disease combination.
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- 2021
31. Insufficienza respiratoria acuta e cronica
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Bonsignore MR, Clini EM, Confalonieri Marco, Corsi S, Crimi C, Crisafulli E, Longhini F, Marchioni A, Nava S, Navalesi P, Pisani L, Spanevello A, Tonelli R, Carlo Rugarli, Bonsignore, Mr, Clini, Em, Confalonieri, Marco, Corsi, S, Crimi, C, Crisafulli, E, Longhini, F, Marchioni, A, Nava, S, Navalesi, P, Pisani, L, Spanevello, A, and Tonelli, R
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ventilazione meccanica ,BPCO ,ossigenoterapia ,Insufficienza respiratoria ,ARDS ,ventilazione non invasiva - Abstract
Insufficienza respiratoria acuta e cronica
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- 2021
32. A modified Yule process to model the evolution of some object-oriented system properties
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Turnu, I., Concas, G., Marchesi, M., Pinna, S., and Tonelli, R.
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- 2011
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33. Blockchain Oriented Software Engineering for Dapp smart contracts in smart energy markets
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Tonelli, R., primary, Marchesi, M., additional, Pinna, A., additional, Mureddu, M., additional, Ghiani, E., additional, Pilo, F., additional, and Galici, M., additional
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- 2022
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34. Data security and protection in blockchain-based local energy markets for smart cities
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Galici, M., primary, Ghiani, E., additional, Mureddu, M., additional, Pilo, F., additional, Pinna, A., additional, Tonelli, R., additional, and Marchesi, M., additional
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- 2022
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35. Real-life comparison of pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis: A 24-month assessment
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Cerri, S, Monari, M, Guerrieri, A, Donatelli, P, Bassi, I, Garuti, M, Luppi, F, Betti, S, Bandelli, G, Carpano, M, Bacchi Reggiani, M, Tonelli, R, Clini, E, Nava, S, Cerri S., Monari M., Guerrieri A., Donatelli P., Bassi I., Garuti M., Luppi F., Betti S., Bandelli G., Carpano M., Bacchi Reggiani M. L., Tonelli R., Clini E., Nava S., Cerri, S, Monari, M, Guerrieri, A, Donatelli, P, Bassi, I, Garuti, M, Luppi, F, Betti, S, Bandelli, G, Carpano, M, Bacchi Reggiani, M, Tonelli, R, Clini, E, Nava, S, Cerri S., Monari M., Guerrieri A., Donatelli P., Bassi I., Garuti M., Luppi F., Betti S., Bandelli G., Carpano M., Bacchi Reggiani M. L., Tonelli R., Clini E., and Nava S.
- Abstract
Background: Real-life data on the use of pirfenidone and nintedanib to treat patients with idiopathic pulmonary fibrosis (IPF) are still scarce. Methods: We compared the efficacy of either pirfenidone (n = 78) or nintedanib (n = 28) delivered over a 24-month period in patients with IPF, followed at two regional clinic centers in Italy, with a group of patients who refused the treatment (n = 36), and who were considered to be controls. All patients completed regular visits at 1- to 3-month intervals, where primary [forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO)] and secondary outcomes (side effects, treatment compliance, and mortality) were recorded. Results: Over time, the decline in FVC and DLCO was significantly higher (p = 0.0053 and p = 0.037, respectively) in controls when compared with the combined treated group, with no significant difference between the two treated groups. Compared to patients with less advanced disease (GAP (Gender, Age, Physiology) stage I), those in GAP stages II and III showed a significantly higher decline in both FVC and DLCO irrespective of the drug taken. Side effects were similarly reported in patients receiving pirfenidone and nintedanib (5% and 7%, respectively), whereas mortality did not differ among the three groups. Conclusion: This real-life study demonstrated that both pirfenidone and nintedanib were equally effective in reducing the decline of FVC and DLCO versus non-treated patients after 24 months of treatment; however, patients with more advanced disease were likely to show a more rapid decline in respiratory function
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- 2019
36. Early inspiratory effort assessment by esophageal manometry predicts noninvasive ventilation outcome in de novo respiratory failure: A pilot study
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Tonelli R., Fantini R., Tabbi L., Castaniere I., Pisani L., Pellegrino M. R., Casa G. D., D'Amico R., Girardis M., Nava S., Clini E. M., Marchioni A., Tonelli R., Fantini R., Tabbi L., Castaniere I., Pisani L., Pellegrino M.R., Casa G.D., D'Amico R., Girardis M., Nava S., Clini E.M., and Marchioni A.
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Acute respiratory distress syndrome ,Esophageal pressure swing ,Noninvasive mechanical ventilation ,Respiratory failure ,Transpulmonary pressure - Abstract
Rationale: The role of inspiratory effort still has to be determined as a potential predictor of noninvasive mechanical ventilation (NIV) failure in acute hypoxic de novo respiratory failure. Objectives: To explore the hypothesis that inspiratory effort might be a major determinant of NIV failure in these patients. Methods: Thirty consecutive patients with acute hypoxic de novo respiratory failure admitted to a single center and candidates for a 24-hour NIV trial were enrolled. Clinical features, tidal change in esophageal pressure (ΔPes), tidal change in dynamic transpulmonary pressure (ΔPL), expiratory VT, and respiratory rate were recorded on admission and 2-4 to 12-24 hours after NIV start and were tested for correlation with outcomes. Measurements and Main Results: ΔPes and ΔPes/ΔPL ratio were significantly lower 2 hours after NIV start in patients who successfully completed the NIV trial (n = 18) compared with those who needed endotracheal intubation (n = 12) (median [interquartile range], 11 [8-15] cmH2O vs. 31.5 [30-36] cm H2O; P
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- 2020
37. Dissecting the Role of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis: Cause or Solution
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Samarelli, Av, Tonelli, R, Heijink, I, Martin Medina, A, Marchioni, A, Bruzzi, G, Castaniere, I, Andrisani, D, Gozzi, F, Manicardi, L, Moretti, A, Cerri, S, Fantini, R, Tabbì, L, Nani, C, Mastrolia, I, Weiss, Dj, Dominici, M, and Clini, E.
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Pharmacology ,mesenchymal stem cells ,cell-based therapy ,extracellular matrix ,Idiopathic pulmonary fibrosis, mesenchymal stromal/stem cells, lung diseases, cell-based therapy, extracellular vesicles ,Idiopathic pulmonary fibrosis ,Review ,exosomes ,respiratory system ,idiopathic pulmonary fibrosis ,respiratory tract diseases ,mesenchymal stromal/stem cells ,extracellular vesicles ,cell based therapy ,lung diseases - Abstract
Idiopathic pulmonary fibrosis (IPF) is one of the most aggressive forms of idiopathic interstitial pneumonias, characterized by chronic and progressive fibrosis subverting the lung's architecture, pulmonary functional decline, progressive respiratory failure, and high mortality (median survival 3 years after diagnosis). Among the mechanisms associated with disease onset and progression, it has been hypothesized that IPF lungs might be affected either by a regenerative deficit of the alveolar epithelium or by a dysregulation of repair mechanisms in response to alveolar and vascular damage. This latter might be related to the progressive dysfunction and exhaustion of the resident stem cells together with a process of cellular and tissue senescence. The role of endogenous mesenchymal stromal/stem cells (MSCs) resident in the lung in the homeostasis of these mechanisms is still a matter of debate. Although endogenous MSCs may play a critical role in lung repair, they are also involved in cellular senescence and tissue ageing processes with loss of lung regenerative potential. In addition, MSCs have immunomodulatory properties and can secrete anti-fibrotic factors. Thus, MSCs obtained from other sources administered systemically or directly into the lung have been investigated for lung epithelial repair and have been explored as a potential therapy for the treatment of lung diseases including IPF. Given these multiple potential roles of MSCs, this review aims both at elucidating the role of resident lung MSCs in IPF pathogenesis and the role of administered MSCs from other sources for potential IPF therapies.
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- 2021
38. Never Give Up: Lesson learned from a severe COVID-19 patient
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Tonelli, R., Iattoni, A., Girardis, M., De Pietri, L., Clini, E., and Mussini, C.
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- 2021
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39. Spontaneous breathing and evolving phenotypes of lung damage in patients with COVID-19
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Tonelli, R, Marchioni, A, Tabbì, L, Fantini, R, Busani, S, Castaniere, I, Andrisani, D, Gozzi, F, Bruzzi, G, Manicardi, L, Demurtas, J, Andreani, A, Cappiello, G, Samarelli, A, and Clini, E.
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acute respiratory failure ,SARS-CoV-2 ,spontaneous breathing ,COVID-19 ,SARS-CoV-2, COVID-19, mechanical ventilation, spontaneous breathing, acute respiratory distress syndrome, acute respiratory failure ,mechanical ventilation ,acute respiratory distress syndrome - Published
- 2021
40. COVIDGuide una app per il triage e l'autovalutazione della COVID-19
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Demurtas, J, Tonelli, R, Celotto, S, Veronese, N, Lagolio, E, Rossi, F, Clini, E, Righi, E, and Meer, A.
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SSDC ,COVID-19 ,e-health ,SSDC, triage, sicurezza, e-health, telemedicina ,triage ,telemedicina ,sicurezza - Published
- 2021
41. Insufficienza respiratoria acuta e cronica (cap.21)
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Bonsignore, Mr, Clini, E, Confalonieri, M, Costi, S, Crimi, C, Crisafulli, E, Longhini, F, Marchioni, A, Nava, S, Navalesi, P, Pisani, L, Spanevello, A, and Tonelli, R.
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riabilitazione respiratoria ,insufficienza respiratoria ,sindrome delle apnee del sonno ,ARDS ,ossigenoterapia domiciliare ,insufficienza respiratoria, sindrome delle apnee del sonno, riabilitazione respiratoria, ARDS, ossigenoterapia domiciliare - Published
- 2021
42. Rugarli. Medicina interna sistematica
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Bonsignore, Mr, Clini, E, Confalonieri, M, Costi, S, Crimi, C, Crisafulli, E, Longhini, F, Marchioni, A, Nava, S, Navalesi, P, Pisani, L, Spanevello, A, and Tonelli, R.
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- 2021
43. Effects of cytokine blocking agents on hospital mortality in patients admitted to ICU with acute respiratory distress syndrome by SARS-CoV2 infection: retrospective cohort study
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Coloretti, I, Busani, S, Biagioni, E, Venturelli, S, Munari, E, Marco, S, Dall’Ara, L, Tosi, M, Clini, E, Tonelli, R, Fantini, R, Mussini, C, Meschiari, M, Guaraldi, G, Cossarizza, A, Alfano, G, Girardis, M, and Gibellini, Lara
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Anakinra ,COVID19 ,Mechanical Ventilation ,Intensive Care Unit ,COVID19, Acute Respiratory Distress Syndrome, Tocilizumab, Anakinra, Intensive Care Unit, Mechanical Ventilation ,Tocilizumab ,Acute Respiratory Distress Syndrome - Published
- 2021
44. Subclinical liver fibrosis in patients with idiopathic pulmonary fibrosis
- Author
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Cocconcelli, E, Tonelli, R, Abbati, G, Marchioni, A, Castaniere, I, Pelizzaro, F, Russo, F, Vegetti, A, Balestro, E, Pietrangelo, A, Richeldi, L, Luppi, F, Spagnolo, P, Clini, E, Cerri, S, Cocconcelli, Elisabetta, Tonelli, Roberto, Abbati, Gianluca, Marchioni, Alessandro, Castaniere, Ivana, Pelizzaro, Filippo, Russo, Francesco Paolo, Vegetti, Alberto, Balestro, Elisabetta, Pietrangelo, Antonello, Richeldi, Luca, Luppi, Fabrizio, Spagnolo, Paolo, Clini, Enrico, Cerri, Stefania, Cocconcelli, E, Tonelli, R, Abbati, G, Marchioni, A, Castaniere, I, Pelizzaro, F, Russo, F, Vegetti, A, Balestro, E, Pietrangelo, A, Richeldi, L, Luppi, F, Spagnolo, P, Clini, E, Cerri, S, Cocconcelli, Elisabetta, Tonelli, Roberto, Abbati, Gianluca, Marchioni, Alessandro, Castaniere, Ivana, Pelizzaro, Filippo, Russo, Francesco Paolo, Vegetti, Alberto, Balestro, Elisabetta, Pietrangelo, Antonello, Richeldi, Luca, Luppi, Fabrizio, Spagnolo, Paolo, Clini, Enrico, and Cerri, Stefania
- Abstract
Data on the presence of subclinical fibrosis across multiple organs in patients with idiopathic lung fibrosis (IPF) are lacking. Our study aimed at investigating through hepatic transient elastography (HTE) the prevalence and clinical impact of subclinical liver fibrosis in a cohort of patients with IPF. Patients referred to the Centre for Rare Lung Disease of the University Hospital of Modena (Italy) from March 2012 to February 2013 with established diagnosis of IPF and without a documented history of liver diseases were consecutively enrolled and underwent HTE. Based on hepatic stiffness status as assessed through METAVIR score patients were categorized as "with liver fibrosis" (corresponding to a METAVIR score of F1-F4) and "without liver fibrosis" (METAVIR F0). Potential predictors of liver fibrosis were investigated through logistic regression model among clinical and serological variables. The overall survival (OS) was assessed according to liver fibrosis and multivariate Cox regression analysis was used to identify independent predictors. In 13 out of 37 patients (35%) with IPF, a certain degree of liver fibrosis was documented. No correlation was found between liver stiffness and clinical-functional parameters. OS was lower in patients 'with liver fibrosis' than in patients 'without liver fibrosis' (median months 33 [23-55] vs. 63 [26-94], p = 0.038). Patients 'with liver fibrosis' presented a higher risk of death at seven years as compared to patients 'without liver fibrosis' (HR = 2.6, 95% CI [1.003-6.7], p = 0.049). Higher level of AST to platelet ratio index (APRI) was an independent predictor of survival (HR = 4.52 95% CI [1.3-15.6], p = 0.02). In our cohort, more than one-third of IPF patients had concomitant subclinical liver fibrosis that negatively affected OS. These preliminary claims further investigation aimed at clarifying the mechanisms beyond multiorgan fibrosis and its clinical implication in patients with IPF.
- Published
- 2021
45. Unusual effectiveness of systemic steroids in Whipple disease
- Author
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Fontana, M., Cerri, S., Bernardelli, G., Brugioni, L., Clini, E., and Tonelli, R.
- Published
- 2020
- Full Text
- View/download PDF
46. Janus-faced amiodarone-induced pneumopathy
- Author
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Cerri, S., Tonelli, R., Faverio, P., Sverzellati, N., Clini, E., and Luppi, F.
- Published
- 2020
- Full Text
- View/download PDF
47. Describing software developers affectiveness through Markov chain models
- Author
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Ortu, M, Conversano, C, Marchesi, M, Tonelli, R, Counsell, S, and Destefanis, G
- Subjects
Human Aspects In Software Engineering ,Data Mining ,Markov Chains - Abstract
In this paper, we present an analysis of more than 500K comments from open-source repositories of software systems. Our aim is to empirically determine how developers interact with each other under certain psychological conditions generated by politeness, sentiment and emotion expressed within developers' comments. Developers involved in an open-source projects do not usually know each other; they mainly communicate through mailing lists, chat rooms, and tools such as issue tracking systems. The way in which they communicate affects the development process and the productivity of the people involved in the project. We evaluated politeness, sentiment and emotions of comments posted by developers and studied the communication flow to understand how they interacted in the presence of impolite and negative comments (and vice versa).Our analysis shows that when in presence of impolite or negative comments, the probability of the next comment being impolite or negative is 14% and 25%, respectively; anger however, has a probability of 40% of being followed by a further anger comment. The result could help managers take control the development phases of a system, since social aspects can seriously affect a developer's productivity. In a distributed environment this may have a particular resonance. Engineering and Physical Sciences Research Council (EPSRC)
- Published
- 2020
48. Response Letter to Tuffet S, et al. and to Michard F, et al
- Author
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Tonelli, R, Tabbì, L, Fantini, R, Castaniere, I, Gozzi, F, Busani, S, Nava, S, Clini, E, and Marchioni, A
- Subjects
acute respiratory distress syndrome, respiratory failure, non-invasive mechanical ventilation, transpulmonary pressure, esophageal pressure - Published
- 2020
49. Erratum: Acute exacerbation of interstitial lung diseases secondary to systemic rheumatic diseases: A prospective study and review of the literature (Journal of Thoracic Disease (2019) 11 (1621-1628) DOI: 10.21037/jtd.2019.03.28)
- Author
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Manfredi, A., Sebastiani, M., Cerri, S., Vacchi, C., Tonelli, R., Della Casa, G., Cassone, G., Spinella, A., Pancaldi, F., Luppi, F., and Salvarani, C.
- Published
- 2020
50. Response letter to Spinelli E, et al. and Jha
- Author
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Tonelli, R, Castaniere, I, Fantini, R, Tabbì, L, Busani, S, Pisani, L, Nava, S, Clini, E, and Marchioni, A.
- Subjects
transpulmonary pressure ,non-invasive mechanical ventilation ,esophageal pressure swings ,respiratory failure ,acute respiratory distress syndrome ,acute respiratory distress syndrome, respiratory failure, non-invasive mechanical ventilation, transpulmonary pressure, esophageal pressure swings - Published
- 2020
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