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6. Baseline plasma SARS-CoV-2 RNA detection predicts an adverse COVID-19 evolution in moderate to severe hospitalized patients

Author

Rizzi, M., Patrucco, F., Trevisan, M., Faolotto, G., Mercandino, A., Strola, C., Ravanini, P., Costanzo, M., Tonello, S., Matino, E., Casciaro, G. F., Croce, A., Rizzi, E., Zecca, E., Pedrinelli, A., Vassia, V., Landi, R., Bellan, M., Castello, L. M., Minisini, R., Mallela, V. R., Avanzi, G. C., Pirisi, M., Lilleri, D., Solidoro, P., Gavelli, F., and Sainaghi, P. P.

Subjects
General Medicine
Abstract

SARS-CoV-2 is a single-stranded RNA virus, known to be the causative agent of COVID-19. As the resulting disease shows a very heterogeneous range of clinical manifestations, the identification of early biomarkers allowing patients stratification according to the expected disease severity is still an unmet clinical need.In this observational prospective cohort study, 137 consecutive patients, testing positive for SARS-CoV-2 infection by nasopharyngeal swab RT-PCR or antigenic test, were enrolled to evaluate their plasma viral load at the time of hospitalization.Even if all of them had a molecular diagnosis of COVID-19, only 29 patients showed a detectable plasma SARS-CoV-2 RNAemia. Such viremic patients also showed other clinical and laboratory finding alterations (increased troponin I, IL-6, RDW-CV, and creatinine levels along with decreased platelet count and glomerular filtration rate). A plasma detectable RNA viral load predicted in hospital death or ICU admission with an odds ratio of 3.53 (CI: 1.44-8.64, P=0.0058), while the lack of a detectable viral load was associated with a faster recovery, with an odds ratio of 4.06 (CI: 1.72-9.59, P=0.0014). These findings were confirmed in multivariate models including age, sex and baseline National Early Warning Score 2 and arterial oxygen tension over inspired oxygen fraction ratio.Our data thus suggest that plasma viral RNA load at the time of hospital admission could represent a useful independent biomarker allowing early patients' stratification according to the expected disease evolution, and driving clinical decisions tailored on the specific needs of the individual patient.

Published
2022
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8. Red cell distribution width is a potential predictor of early relapse in polymyalgia rheumatica

Author

Soddu, D., primary, Sola, D., additional, Bellan, M., additional, Boin, E., additional, Cittone, M.G., additional, Zecca, E., additional, Matino, E., additional, Pedrazzoli, R., additional, Rizzi, E., additional, Pedrinelli, A.R., additional, Tonello, S., additional, Vassia, V., additional, Landi, R., additional, Pirisi, M., additional, and Sainaghi, P.P., additional

Published
2021
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9. Simple parameters from complete blood count predict in-hospital mortality in covid-19

Author

Bellan, M., Azzolina, D., Hayden, E., Gaidano, G., Pirisi, M., Acquaviva, A., Aimaretti, G., Valletti, P. A., Angilletta, R., Arioli, R., Avanzi, G. C., Avino, G., Balbo, P. E., Baldon, G., Baorda, F., Barbero, E., Baricich, A., Barini, M., Barone-Adesi, F., Battistini, S., Beltrame, M., Bertoli, M., Bertolin, S., Bertolotti, M., Betti, M., Bobbio, F., Boffano, P., Boglione, L., Borre, S., Brucoli, M., Calzaducca, E., Cammarata, E., Cantaluppi, V., Cantello, R., Capponi, A., Carriero, A., Casciaro, G. F., Castello, L. M., Ceruti, F., Chichino, G., Chirico, E., Cisari, C., Cittone, M. G., Colombo, C., Comi, C., Croce, E., Daffara, T., Danna, P., Corte, F. D., de Vecchi, S., Dianzani, U., Benedetto, D. D., Esposto, E., Faggiano, F., Falaschi, Z., Ferrante, D., Ferrero, A., Gagliardi, I., Galbiati, A., Gallo, S., Garavelli, P. L., Gardino, C. A., Garzaro, M., Gastaldello, M. L., Gavelli, F., Gennari, A., Giacomini, G. M., Giacone, I., Via, V. G., Giolitti, F., Gironi, L. C., Gramaglia, C., Grisafi, L., Inserra, I., Invernizzi, M., Krengli, M., Labella, E., Landi, I. C., Landi, R., Leone, I., Lio, V., Lorenzini, L., Maconi, A., Malerba, M., Manfredi, G. F., Martelli, M., Marzari, L., Marzullo, P., Mennuni, M., Montabone, C., Morosini, U., Mussa, M., Nerici, I., Nuzzo, A., Olivieri, C., Padelli, S. A., Panella, M., Parisini, A., Pasche, A., Patrucco, F., Patti, G., Pau, A., Pedrinelli, A. R., Percivale, I., Ragazzoni, L., Re, R., Rigamonti, C., Rizzi, E., Rognoni, A., Roveta, A., Salamina, L., Santagostino, M., Saraceno, M., Savoia, P., Sciarra, M., Schimmenti, A., Scotti, L., Spinoni, E., Smirne, C., Tarantino, V., Tillio, P. A., Tonello, S., Vaschetto, R., Vassia, V., Zagaria, D., Zavattaro, E., Zeppegno, P., Zottarelli, F., Sainaghi, P. P., Aiosa, G., Airoldi, A., Barco, A., Bargiacchi, O., Bazzano, S., Berni, P., Bianchi, B., Bianco, S., Biffi, S., Binda, V., Bolgeo, T., Bolla, C., Bonato, V., Bonizzoni, G., Bragantini, A., Brustia, D., Bullara, V., Burlone, M., Brustia, F., Caccia, S., Calareso, A., Cammarota, G., Cancelliere, L., Carbone, R., Cassinari, A., Ceriani, E., Cena, T., Clivati, E., Collimedaglia, L., Colombatto, A., Cornella, C., Costanzo, M., Croce, A., de Benedittis, C., Delorenzi, S., Dionisio, R., Donato, P., Esposito, M., Fangazio, S., Feggi, A., Ferrillo, S., Foci, V., Fra, G. P., Gaggino, C., Gambaro, E., Gattoni, E., Gattoni, L., Giacchero, F., Gianfreda, R., Giubertoni, A., Grecu, L., Grossi, F., Guglielmetti, G., Guido, S., Iannantuoni, G., Ingrao, S., Jona, A., Lazzarich, E., Lissandrin, R., Maduli, E., Magne, F., Mantia, E., Marangon, D., Massara, M., Matino, E., Mauri, M. G., Menegatti, M., Moglia, R., Molinari, R., Morelli, S., Morlino, P., Naldi, P., Nebbiolo, C., Omodeo, P., Palmieri, D., Panero, A., Parodi, M., Pedrazzoli, R., Pelazza, C., Penpa, S., Perucca, R., Pirovano, A., Pittau, S., Pochetti, P., Poletti, F., Polla, B., Prandi, P., Prodam, F., Prosperini, P., Puma, A., Quaglia, M., Raie, A., Rapetti, R., Ravera, S., Re, A., Reale, M., Rossati, A., Rossi, M., Rossi, P., Rostagno, R., Salomoni, G., Sama, M. T., Sarchi, E., Sarcoli, M., Sarda, C., Sguazzotti, I., Soddu, D., Sola, D., Stobbione, P., Todoerti, M., Vallese, G. C., Varrasi, C., Veia, A., Vignazia, G. L., Zanotti, I., Zecca, E., Zichittella, D., Zisa, G., and Zoppis, E.

Subjects
Adult, Male, medicine.medical_specialty, Medicine (General), Multivariate analysis, Article Subject, Clinical Decision Rules, COVID-19, Prognosis, Blood Cell Count, Hospital Mortality, Severity of Illness Index, Clinical Biochemistry, Asymptomatic, Severity of Illness Index, NO, R5-920, Internal medicine, Clinical Decision Rules, Severity of illness, Genetics, 80 and over, Medicine, Humans, Hospital Mortality, Molecular Biology, Aged, Retrospective Studies, Aged, 80 and over, medicine.diagnostic_test, business.industry, Biochemistry (medical), Complete blood count, COVID-19, Retrospective cohort study, Red blood cell distribution width, General Medicine, Odds ratio, Middle Aged, Prognosis, Female, Italy, Multivariate Analysis, Blood Cell Count, Cohort, medicine.symptom, business, Research Article
Abstract

Introduction. The clinical course of Coronavirus Disease 2019 (COVID-19) is highly heterogenous, ranging from asymptomatic to fatal forms. The identification of clinical and laboratory predictors of poor prognosis may assist clinicians in monitoring strategies and therapeutic decisions. Materials and Methods. In this study, we retrospectively assessed the prognostic value of a simple tool, the complete blood count, on a cohort of 664 patients ( F 260; 39%, median age 70 (56-81) years) hospitalized for COVID-19 in Northern Italy. We collected demographic data along with complete blood cell count; moreover, the outcome of the hospital in-stay was recorded. Results. At data cut-off, 221/664 patients (33.3%) had died and 453/664 (66.7%) had been discharged. Red cell distribution width (RDW) ( χ 2 10.4; p < 0.001 ), neutrophil-to-lymphocyte (NL) ratio ( χ 2 7.6; p = 0.006 ), and platelet count ( χ 2 5.39; p = 0.02 ), along with age ( χ 2 87.6; p < 0.001 ) and gender ( χ 2 17.3; p < 0.001 ), accurately predicted in-hospital mortality. Hemoglobin levels were not associated with mortality. We also identified the best cut-off for mortality prediction: a NL ratio > 4.68 was characterized by an odds ratio for in-hospital mortality OR = 3.40 (2.40-4.82), while the OR for a RDW > 13.7 % was 4.09 (2.87-5.83); a platelet count > 166,000 /μL was, conversely, protective (OR: 0.45 (0.32-0.63)). Conclusion. Our findings arise the opportunity of stratifying COVID-19 severity according to simple lab parameters, which may drive clinical decisions about monitoring and treatment.

Published
2021

24. Charged molecular silica trigger in vitro NETosis in human granulocytes via both oxidative and autophagic pathways.

Author

RIZZI, M., CARNIATO, F., TONELLO, S., MIGLIARIO, M., INVERNIZZI, M., ROCCHETTI, V., MARCHESE, L., and RENÒ, F.

Abstract

OBJECTIVE: Neutrophils play a key role in immunity and are known to respond to exogenous threats by releasing neutrophil extracellular traps (NETs) through NETosis, a process involving the release of neutrophils nuclear DNA decorated with proteins into the extracellular space. In this study, attention has been focused on the ability of differently charged molecular systems polyhedral oligomeric silsesquioxanes (POSS) to induce NETosis. MATERIALS AND METHODS: NETs formation was induced by phorbol myristate acetate (PMA) (positive control) and POSS treatment and visualized by confocal microscopy. Moreover, NETs production was quantified by Sytox green staining. Oxidative stress, autophagy as well as endocytosis involvement in the observed phenomena was evaluated by a specific inhibitory approach. RESULTS: Results obtained in this study demonstrate a POSS time and dose-dependent ability in inducing NETs release irrespectively to their charge. POSS induced NETosis is a consequence of their internalization, as demonstrated by the strong reduction in NETs formation after endocytosis inhibition. Moreover, POSS induced NETosis involves both an increase in superoxide anion generation and autophagy pathway activation as demonstrated by the protective effect displayed by sodium azide and wortmannin. CONCLUSIONS: Data presented in this study indicate that nanomaterials and molecular systems could have a role in the onset of inflammatory phenomena. [ABSTRACT FROM AUTHOR]

Published
2018

25. SPLENO-SYSTEMIC SHUNTS AND COVERT HEPATIC ENCEPHALOPATY

Author

Tonello, S., Montagnese, S., Schiff, S., Amodio, P., Bizzotto, P., Pesce, P., Gatta, A., Bolognesi, M., David Sacerdoti, and Bombonato, G.

Subjects
Liver cirrhosis, portal hypertension, Doppler sonography
Published
2013

26. Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study

Author

Comi, G, Battaglia, Ma, Bertolotto, A, Del Sette, M, Ghezzi, A, Malferrari, G, Salvetti, M, Sormani, Mp, Tesio, L, Stolz, E, Zaratin, P, Mancardi, G, Baracchini, C, Bergamaschi, R, Bortolon, F, Bratina, A, Brescia Morra, V, Buccafusca, M, Busso, M, Capra, R, Carraro, N, Cavalla, P, Cecconi, P, Centonze, D, Ciampanelli, D, Cirrito, M, Ciuffoli, A, Coppo, L, Costantino, G, Cottone, S, Deboni, A, De Rossi, N, Di Maggio, L, Favaretto, E, Finocchi, C, Gaeta, R, Gallo, Paolo, Giometto, B, Granieri, E, Grazioli, S, Grimaldi, L, Guccione, A, Iemolo, F, Lochner, P, Lugaresi, A, Maimone, D, Mancini, M, Mantegazza, R, Marrosu, Mg, Menci, E, Monti, L, Motti, L, Nuzzaco, Gm, Pascazio, L, Patti, F, Protti, A, Provinciali, L, Rossato, D, Rovaris, M, Sanguigni, S, Sanzaro, E, Sette, G, Spinelli, M, Stecchi, S, Stefanini, M, Tezzon, F, Tola, Mr, Tonello, S, Trojano, M, Ulivelli, M, Uselli, S, Viaro, F, and Zedde, M. L.

Published
2013

37. Raccomandazioni sul trattamento del paziente odontoiatrico in terapia anticoagulante

Author

Adrario, E., Alberton, M., Antonimi, M., Barbieri, A., Bazzato, Mf, Biasini, E., Bosco, M., Boscolo, I., Bozza, R., Camaioni, D., DA CORTE, S., DI MASSA, A., Dpl, Diana, Favaro, R., Giacomo, Favero, Giovanni, Bavero, Floreani, S., Ghiotto, Pg, Lorenzi, P., Manani, G., Marino, D., Mazzuchin, M., Olivi, R., Petrini, F., Risita, M., Rizzo, F., Ruffato, L., Ruggi, M., Ruzza, C., Semenzato, E., Stifano, M., Tognazzo, F., Tommasino, C., Tonello, S., Trevisan, A., Vellardi, P., and Zanette, Gastone

Published
2003

38. RACCOMANDAZIONI SULLE CARATTERISTICHE DELL'AMBULATORIO ODONTOIATRICO IN RELAZIONE ALL'EROGAZIONE DI INTERVENTI DI ANESTESIA ODONTOSTOMATOLOGICA EFFETTUATI IN ANSIOLISI

Author

Adrario, E., Alberton, M., Antonimi, M., Barbieri, A., Bazzato, Mf, Biasini, E., Bosco, M., Boscolo, I., Bozza, R., Camaioni, D., DA CORTE, S., DI MASSA, A., Dpl, Diana, Favaro, R., Giacomo, Favero, Giovanni, Bavero, Floreani, S., Ghiotto, Pg, Lorenzi, P., Manani, G., Marino, D., Mazzuchin, M., Olivi, R., Petrini, F., Risita, M., Rizzo, F., Ruffato, L., Ruggi, M., Ruzza, C., Semenzato, E., Stifano, M., Tognazzo, F., Tommasino, C., Tonello, S., Trevisan, A., Vellardi, P., and Zanette, Gastone

Published
2003

43. Epiregulin-loaded PLGA nanoparticles increase human keratinocytes proliferation: preliminary data.

Author

RIZZI, M., MIGLIARIO, M., ROCCHETTI, V., TONELLO, S., and RENÒ, F.

Abstract

OBJECTIVE: Epiregulin is a member of the epidermal growth factor (EGF) family produced by keratinocytes: the aim of this study was to investigate the ability of biocompatible nanoparticles loaded with such growth factor to increase human keratinocytes proliferation. MATERIALS AND METHODS: Different PLGA (Poly-d,l-lactide-co-glycolide)-nanoparticles (NPs) formulations have been characterized in size and zeta potential by dynamic light scattering (DLS) analysis. The ability of the different PLGA-NPs formulations to adhere onto dental surfaces has been tested, and epiregulin-enriched PLGA-NPs has been produced. Epiregulin release from NPs has been tested by enzyme-linked immunosorbent (ELISA) assay and the proliferative effects of epiregulin-NPs on human keratinocytes have been evaluated. RESULTS: DLS analysis revealed a different size distribution depending on the PLA/PGA (poly lactic acid/poly glycolic acid) ratio used. 50:50 PLGA-NPs exhibited the smaller size and the best dental adhesive ability. Moreover, such epiregulin-loaded NPs was able to increase cell proliferation. CONCLUSIONS: Direct dental pocket drug delivery implies the NPs solution loading onto the dental surface at the cement-enamel junction level: 50:50 PLGA-NPs, with their small size and excellent adhesive ability, represent an interesting tool to deliver epiregulin directly where there is the need for epithelial proliferation. These results describe a possible strategy for periodontal pocket delivery of Epiregulin-loaded PLGA- NPs and might provide a new approach for the treatment of gingival recession, where gingival epithelium proliferation is needed. [ABSTRACT FROM AUTHOR]

Published
2016

45. Pre-odontoblast proliferation induced by near-infrared laser stimulation.

Author

RIZZI, M., MIGLIARIO, M., ROCCHETTI, V., TONELLO, S., and RENÒ, F.

Abstract

OBJECTIVE: Laser therapy is known to stimulate cell proliferation and differentiation, an effect called "biostimulation". Although many clinical applications of laser therapy take advantage from such positive effect, the underlying molecular mechanisms are not fully understood. The aim of this work was to investigate the effect of near-infrared laser stimulation on rat pre-odontoblast cells (MDPC-23 cells) and the molecular mechanism/s involved. MATERIALS AND METHODS: MDPC-23 cells were stimulated with a near-infrared (980 nm) laser source with different energy settings (1- 50 J, corresponding to 0.65-32.47 J/cm2) and cell proliferation was evaluated by manual count. ERK 1/2 pathway activation was evaluated by Western blot analysis. RESULTS: 1-10 J stimulation (corresponding to 0.65-6.5 J/cm²) significantly increase MDPC- 23 cell proliferation and such effect seems to be mediated by ERK 1/2 signalling pathway activation, showing a key role of ERK 1/2 pathway in mediating the proliferative response induced by laser stimulation. CONCLUSIONS: Near infrared laser stimulation with low energies (1-10 J) is able to increase cell proliferation through ERK 1/2 signalling pathway activation. At the same time, higher energy stimulation (25-50 J) induces an initial toxic effect, probably activating pro-apoptotic signalling molecules, downstream ERK 1/2 kinase. Such results foster the application of this therapeutic approach in different clinical settings in which a regenerative tissue response is needed. [ABSTRACT FROM AUTHOR]

Published
2016

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