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187 results on '"Tong, Dali"'

4. Meticulous anatomic microreplantation for complete penile amputation: a report of 4 cases

Author

WANG Yihe, WANG Peng, LUO Yong, ZHANG Yong, and TONG Dali

Subjects
penile amputation, penile injury, microsurgery, replantation, vascular anastomosis, Medicine (General), R5-920
Abstract

Objective To improve the early management of penile amputation injury by analyzing and summarizing our microreplantation experience of 4 cases of complete penile amputation. Methods Clinical data of 4 patients with complete penile amputation admitted to our hospital from March 2018 to October 2022 were collected, and their related clinical features, microsurgical procedures, post-operative treatment and follow-up outcomes were retrospectively analyzed. Results Meticulous anatomical microreplantation was successfully performed on all the 4 patients. Two of them received successfully bilateral penile dorsal arteries anastomosis, and the other two got only one dorsal artery anastomosis. All patients completed anastomosis of deep dorsal penile vein, and 3 of them had superficial dorsal vein anastomosis. Anastomosis of 4~6 dorsal nerves on both sides of the back of the penis were completed in all the patients. The operation time ranged from 6.5 to 7.5 h, with an average of 6.9 h. The warm ischemia period was 1~4 h, averagely 1.9 h. During the follow-up, 3 cases obtained successful penis replantation, although 2 of them had partial necrosis of foreskin, which healed naturally after 2~3 months. These 3 patients had normal urinations after operation, and had an erectile hardness score of 3~4 in 3~6 months after operation, with satisfactory self-reported recoveries. Conclusion For the patients with short warm ischemia period after complete penile amputation, microreplantation should be carried out as soon as possible in order to obtain satisfactory appearance and functional recovery of the penis.

Published
2023
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9. Altered visual cortical processing in a mouse model of MECP2 duplication syndrome

Author

Zhang, Dinghong, Yu, Bin, Liu, Jing, Jiang, Weiqian, Xie, Taorong, Zhang, Ran, Tong, Dali, Qiu, Zilong, and Yao, Haishan

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Brain Disorders, Neurosciences, Genetics, Mental Health, Rett Syndrome, Pediatric, Intellectual and Developmental Disabilities (IDD), Neurodegenerative, Eye Disease and Disorders of Vision, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Underpinning research, 1.1 Normal biological development and functioning, Mental health, Neurological, Age Factors, Animals, Contrast Sensitivity, Disease Models, Animal, Electrophysiology, Female, Gene Expression Regulation, Male, Mental Retardation, X-Linked, Methyl-CpG-Binding Protein 2, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Photic Stimulation, Signal-To-Noise Ratio, Visual Cortex, Visual Perception
Abstract

As an epigenetic modulator of gene expression, Methyl-CpG binding protein 2 (MeCP2) is essential for normal neurological function. Dysfunction of MeCP2 is associated with a variety of neurological disorders. MECP2 gene duplication in human causes neuropsychiatric symptoms such as mental retardation and autism. MeCP2 overexpression in mice results in neurobehavioural disorders, dendritic abnormalities, and synaptic defects. However, how gain of MeCP2 function influences cortical processing of sensory information remains unclear. In this study, we examined visual processing in a mouse model of MECP2 duplication syndrome (MECP2 Tg1 mouse) at 8 and 14 weeks, which were before and after the onset of behavioural symptoms, respectively. In vivo extracellular recordings from primary visual cortex (V1) showed that neurons in Tg1 mice at both adult ages preferred higher spatial frequencies (SFs) than those in wild-type (WT) littermate controls, and the semi-saturation contrasts of neurons were lower in Tg1 mice at 8 weeks but not at 14 weeks. Behavioural experiments showed that the performance for visual detection at high SFs and low contrasts was higher in MECP2 Tg1 mice. Thus, MeCP2 gain-of-function in mice leads to higher visual acuity and contrast sensitivity, both at the levels of cortical response and behavioural performance.

Published
2017

14. Table S1 from Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration

Author

Liu, Qiuli, primary, Tong, Dali, primary, Liu, Gaolei, primary, Gao, Jie, primary, Wang, Lin-ang, primary, Xu, Jing, primary, Yang, Xingxia, primary, Xie, Qiubo, primary, Huang, Yiqiang, primary, Pang, Jian, primary, Wang, Luofu, primary, He, Yong, primary, Zhang, Dianzheng, primary, Ma, Qiang, primary, Lan, Weihua, primary, and Jiang, Jun, primary

Published
2023
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15. Figure S3 from Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration

Author

Liu, Qiuli, primary, Tong, Dali, primary, Liu, Gaolei, primary, Gao, Jie, primary, Wang, Lin-ang, primary, Xu, Jing, primary, Yang, Xingxia, primary, Xie, Qiubo, primary, Huang, Yiqiang, primary, Pang, Jian, primary, Wang, Luofu, primary, He, Yong, primary, Zhang, Dianzheng, primary, Ma, Qiang, primary, Lan, Weihua, primary, and Jiang, Jun, primary

Published
2023
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16. A survey and antibody test following the surge of SARS-CoV-2 Omicron infection in China

Author

Yao, Yichuan, primary, Yang, Yunru, additional, Wu, Qiqin, additional, Liu, Mengyao, additional, Bao, Wei, additional, Wang, Qiutong, additional, Cheng, Meijun, additional, Chen, Yunuo, additional, Cai, Yuan, additional, Zhang, Mei, additional, Yao, Jingxue, additional, He, Hongliang, additional, Jin, Changjiang, additional, Xue, Tian, additional, Zheng, Changcheng, additional, Jin, Tengchuan, additional, and Tong, Dali, additional

Published
2023
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18. Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling

Author

Wei, Min, primary, Sun, Yanping, additional, Li, Shouzhen, additional, Chen, Yunuo, additional, Li, Longfei, additional, Fang, Minghao, additional, Shi, Ronghua, additional, Tong, Dali, additional, Chen, Jutao, additional, Ma, Yuqian, additional, Qu, Kun, additional, Zhang, Mei, additional, and Xue, Tian, additional

Published
2023
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21. Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

Author

Tong, Dali, primary, Zhang, Mei, additional, Yang, Yunru, additional, Xia, Han, additional, Tong, Haiyang, additional, Zhang, Huajun, additional, Zeng, Weihong, additional, Liu, Muziying, additional, Wu, Yan, additional, Ma, Huan, additional, Hu, Xue, additional, Liu, Weiyong, additional, Cai, Yuan, additional, Yao, Yanfeng, additional, Yao, Yichuan, additional, Liu, Kunpeng, additional, Shan, Shifang, additional, Li, Yajuan, additional, Gao, Ge, additional, Guo, Weiwei, additional, Peng, Yun, additional, Chen, Shaohong, additional, Rao, Juhong, additional, Zhao, Jiaxuan, additional, Min, Juan, additional, Zhu, Qingjun, additional, Zheng, Yanmin, additional, Liu, Lianxin, additional, Shan, Chao, additional, Zhong, Kai, additional, Qiu, Zilong, additional, Jin, Tengchuan, additional, Chiu, Sandra, additional, Yuan, Zhiming, additional, and Xue, Tian, additional

Published
2022
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27. Additional file 5 of Immunotherapy in patients with metastatic castration-resistant prostate cancer: a meta-analysis of data from 7 phase III studies and 3 phase II studies

Author

Zhang, Anqiang and Tong, Dali

Abstract

Additional file 5: The trials about pembrolizumab approved to use for advanced solid tumors with the multiple genetic abnormalities (MSI-H or dMMR or TMB-H) were reviewed based on objective response rate (ORR), PFS and complete responses (CRs).

Published
2022
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28. Additional file 3 of Immunotherapy in patients with metastatic castration-resistant prostate cancer: a meta-analysis of data from 7 phase III studies and 3 phase II studies

Author

Zhang, Anqiang and Tong, Dali

Abstract

Additional file 3: Three phase II clinical trials were included about Ipilimumab and Nivolumab after screening. In detail, most prostate cancer immunotherapy studies are still in phase II clinical trials, and the number of clinical trials above phase III is very limited. We further screened 86 phase II clinical trials about ICBs, and three trials about Ipilimumab and Nivolumab were included based on maintenance therapy.

Published
2022
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29. Additional file 4 of Immunotherapy in patients with metastatic castration-resistant prostate cancer: a meta-analysis of data from 7 phase III studies and 3 phase II studies

Author

Zhang, Anqiang and Tong, Dali

Abstract

Additional file 4: Three types of therapy based on ipilimumab, sipuleucel-T and two vaccines respectively for subgroup meta-analysis based on clinical endpoints OS and PFS were performed. In term of OS, immunotherapy based on sipuleucel-T subgroup were able to decrease the risk of death in patients (HR = 0.73; 95%CI, 0.61–0.88; p = 0.001), indicating that sipuleucel-T is effective to improve OS. In term of PFS, in ipilimumab subpopulation, immunotherapy was able to decrease the risk of progression over placebo by 31% (HR = 0.69; 95%CI, 0.61–0.77; p = 0.000), which indicates that ipilimumab is effective to improve PFS.

Published
2022
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30. Additional file 1 of Immunotherapy in patients with metastatic castration-resistant prostate cancer: a meta-analysis of data from 7 phase III studies and 3 phase II studies

Author

Zhang, Anqiang and Tong, Dali

Abstract

Additional file 1: The materials and methods section of meta-analysis including the descriptions of study outcome, inclusion and exclusion criteria, search strategy, study selection, data extraction and quality assessment and statistical analysis.

Published
2022
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34. The autism risk gene CNTN4 modulates dendritic spine formation

Author

Zhao, Rongjuan, primary, Zhu, Tengfei, additional, Liu, Qiong, additional, Tian, Qi, additional, Wang, Meng, additional, Chen, Jingjing, additional, Tong, Dali, additional, Yu, Bin, additional, Guo, Hui, additional, Xia, Kun, additional, Qiu, Zilong, additional, and Hu, Zhengmao, additional

Published
2021
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37. Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

Author

Tong, Dali, primary, Zhang, Mei, additional, Yang, Yunru, additional, Xia, Han, additional, Tong, Haiyang, additional, Zhang, Huajun, additional, Zeng, Weihong, additional, Liu, Muziying, additional, Wu, Yan, additional, Ma, Huan, additional, Hu, Xue, additional, Liu, Weiyong, additional, Cai, Yuan, additional, Yao, Yanfeng, additional, Yao, Yichuan, additional, Liu, Kunpeng, additional, Shan, Shifang, additional, Li, Yajuan, additional, Gao, Ge, additional, Guo, Weiwei, additional, Peng, Yun, additional, Chen, Shaohong, additional, Rao, Juhong, additional, Zhao, Jiaxuan, additional, Min, Juan, additional, Zhu, Qingjun, additional, Zheng, Yanmin, additional, Liu, Lianxin, additional, Shan, Chao, additional, Zhong, Kai, additional, Qiu, Zilong, additional, Jin, Tengchuan, additional, Chiu, Sandra, additional, Yuan, Zhiming, additional, and Xue, Tian, additional

Published
2021
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39. Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2

Author

Liu, Qiuli, primary, Pang, Jian, additional, Wang, Lin‐ang, additional, Huang, Zhuowei, additional, Xu, Jing, additional, Yang, Xingxia, additional, Xie, Qiubo, additional, Huang, Yiqiang, additional, Tang, Tang, additional, Tong, Dali, additional, Liu, Gaolei, additional, Wang, Luofu, additional, Zhang, Dianzheng, additional, Ma, Qiang, additional, Xiao, Hualiang, additional, Lan, Weihua, additional, Qin, Jun, additional, and Jiang, Jun, additional

Published
2020
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44. LSD1 Promotes Bladder Cancer Progression by Upregulating LEF1 and Enhancing EMT

Author

Xie, Qiubo, primary, Tang, Tang, additional, Pang, Jian, additional, Xu, Jing, additional, Yang, Xingxia, additional, Wang, Linang, additional, Huang, Yiqiang, additional, Huang, Zhuowei, additional, Liu, Gaolei, additional, Tong, Dali, additional, Zhang, Yao, additional, Wang, Luofu, additional, Zhang, Dianzheng, additional, Lan, Weihua, additional, Liu, Qiuli, additional, and Jiang, Jun, additional

Published
2020
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45. A Renal Cell Carcinoma with Biallelic Somatic TSC2 Mutation: Clinical Study and Literature Review

Author

Pang, Jian, primary, Wang, Linang, additional, Xu, Jing, additional, Xie, Qiubo, additional, Liu, Qiuli, additional, Tong, Dali, additional, Liu, Gaolei, additional, Huang, Yiqiang, additional, Yang, Xingxia, additional, Pan, Jinhong, additional, Yan, Xiaochu, additional, Ma, Qiang, additional, Zhang, Dianzheng, additional, and Jiang, Jun, additional

Published
2019
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47. Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration

Author

Liu, Qiuli, primary, Tong, Dali, additional, Liu, Gaolei, additional, Gao, Jie, additional, Wang, Lin-ang, additional, Xu, Jing, additional, Yang, Xingxia, additional, Xie, Qiubo, additional, Huang, Yiqiang, additional, Pang, Jian, additional, Wang, Luofu, additional, He, Yong, additional, Zhang, Dianzheng, additional, Ma, Qiang, additional, Lan, Weihua, additional, and Jiang, Jun, additional

Published
2018
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49. Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2.

Author

Liu, Qiuli, Pang, Jian, Wang, Lin‐ang, Huang, Zhuowei, Xu, Jing, Yang, Xingxia, Xie, Qiubo, Huang, Yiqiang, Tang, Tang, Tong, Dali, Liu, Gaolei, Wang, Luofu, Zhang, Dianzheng, Ma, Qiang, Xiao, Hualiang, Lan, Weihua, Qin, Jun, and Jiang, Jun

Subjects
PROSTATE cancer, CASTRATION-resistant prostate cancer, CANCER invasiveness, DEMETHYLASE, PROMOTERS (Genetics)
Abstract

Neuroendocrine prostate cancer (NEPC) is a more aggressive subtype of castration‐resistant prostate cancer (CRPC). Although it is well established that PHF8 can enhance prostate cancer cell proliferation, whether PHF8 is involved in prostate cancer initiation and progression is relatively unclear. By comparing the transgenic adenocarcinoma of the mouse prostate (TRAMP) mice with or without Phf8 knockout, we systemically examined the role of PHF8 in prostate cancer development. We found that PHF8 plays a minimum role in initiation and progression of adenocarcinoma. However, PHF8 is essential for NEPC because not only is PHF8 highly expressed in NEPC but also animals without Phf8 failed to develop NEPC. Mechanistically, PHF8 transcriptionally upregulates FOXA2 by demethylating and removing the repressive histone markers on the promoter region of the FOXA2 gene, and the upregulated FOXA2 subsequently regulates the expression of genes involved in NEPC development. Since both PHF8 and FOXA2 are highly expressed in NEPC tissues from patients or patient‐derived xenografts, the levels of PHF8 and FOXA2 can either individually or in combination serve as NEPC biomarkers and targeting either PHF8 or FOXA2 could be potential therapeutic strategies for NEPC treatment. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2021
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50. The roles of the COX2/PGE2/EP axis in therapeutic resistance

Author

Tong, Dali, primary, Liu, Qiuli, additional, Wang, Lin-ang, additional, Xie, Qiubo, additional, Pang, Jian, additional, Huang, Yiqiang, additional, Wang, Luofu, additional, Liu, Gaolei, additional, Zhang, Dianzheng, additional, Lan, Weihua, additional, and Jiang, Jun, additional

Published
2018
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