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1. Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes

Author

Mirhadi, Shideh, Tam, Shirley, Li, Quan, Moghal, Nadeem, Pham, Nhu-An, Tong, Jiefei, Golbourn, Brian J., Krieger, Jonathan R., Taylor, Paul, Li, Ming, Weiss, Jessica, Martins-Filho, Sebastiao N., Raghavan, Vibha, Mamatjan, Yasin, Khan, Aafaque A., Cabanero, Michael, Sakashita, Shingo, Huo, Kugeng, Agnihotri, Sameer, Ishizawa, Kota, Waddell, Thomas K., Zadeh, Gelareh, Yasufuku, Kazuhiro, Liu, Geoffrey, Shepherd, Frances A., Moran, Michael F., and Tsao, Ming-Sound

Published
2022
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3. Tankyrase represses autoinflammation through the attenuation of TLR2 signaling

Author

Matsumoto, Yoshinori, Dimitriou, Ioannis D., La Rose, Jose, Lim, Melissa, Camilleri, Susan, Law, Napoleon, Adissu, Hibret A., Tong, Jiefei, Moran, Michael F., Chruscinski, Andrzej, He, Fang, Asano, Yosuke, Katsuyama, Takayuki, Sada, Ken-ei, Wada, Jun, and Rottapel, Robert

Subjects
Immunological research, Inflammation -- Development and progression, Transferases -- Health aspects -- Genetic aspects, Cellular signal transduction -- Research, TLR2 -- Health aspects -- Genetic aspects, Autoimmune diseases -- Development and progression, Health care industry
Abstract

Dysregulation of Toll-like receptor (TLR) signaling contributes to the pathogenesis of autoimmune diseases. Here, we provide genetic evidence that tankyrase, a member of the poly(ADP-ribose) polymerase (PARP) family, negatively regulates TLR2 signaling. We show that mice lacking tankyrase in myeloid cells developed severe systemic inflammation with high serum inflammatory cytokine levels. We provide mechanistic evidence that tankyrase deficiency resulted in tyrosine phosphorylation and activation of TLR2 and show that phosphorylation of tyrosine 647 within the TIR domain by SRC and SYK kinases was critical for TLR2 stabilization and signaling. Last, we show that the elevated cytokine production and inflammation observed in mice lacking tankyrase in myeloid cells were dependent on the adaptor protein 3BP2, which is required for SRC and SYK activation. These data demonstrate that tankyrase provides a checkpoint on the TLR-mediated innate immune response., Introduction The Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) derived from microbes to drive the innate immune response (1-3). TLR activation induces NF-[kappa]B, a master transcription factor that controls [...]

Published
2022
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5. Data from CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration

Author

Wei, Yuhong, primary, Vellanki, Ravi N., primary, Coyaud, Étienne, primary, Ignatchenko, Vladimir, primary, Li, Lei, primary, Krieger, Jonathan R., primary, Taylor, Paul, primary, Tong, Jiefei, primary, Pham, Nhu-An, primary, Liu, Geoffrey, primary, Raught, Brian, primary, Wouters, Bradly G., primary, Kislinger, Thomas, primary, Tsao, Ming Sound, primary, and Moran, Michael F., primary

Published
2023
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6. Table S4 from CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration

Author

Wei, Yuhong, primary, Vellanki, Ravi N., primary, Coyaud, Étienne, primary, Ignatchenko, Vladimir, primary, Li, Lei, primary, Krieger, Jonathan R., primary, Taylor, Paul, primary, Tong, Jiefei, primary, Pham, Nhu-An, primary, Liu, Geoffrey, primary, Raught, Brian, primary, Wouters, Bradly G., primary, Kislinger, Thomas, primary, Tsao, Ming Sound, primary, and Moran, Michael F., primary

Published
2023
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7. Figure S4 from CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration

Author

Wei, Yuhong, primary, Vellanki, Ravi N., primary, Coyaud, Étienne, primary, Ignatchenko, Vladimir, primary, Li, Lei, primary, Krieger, Jonathan R., primary, Taylor, Paul, primary, Tong, Jiefei, primary, Pham, Nhu-An, primary, Liu, Geoffrey, primary, Raught, Brian, primary, Wouters, Bradly G., primary, Kislinger, Thomas, primary, Tsao, Ming Sound, primary, and Moran, Michael F., primary

Published
2023
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8. Supplementary Figure 2 from Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer

Author

Mirhadi, Shideh, primary, Zhang, Wen, primary, Pham, Nhu-An, primary, Karimzadeh, Fereshteh, primary, Pintilie, Melania, primary, Tong, Jiefei, primary, Taylor, Paul, primary, Krieger, Jonathan, primary, Pitcher, Bethany, primary, Sykes, Jenna, primary, Wybenga-Groot, Leanne, primary, Fladd, Christopher, primary, Xu, Jing, primary, Wang, Tao, primary, Cabanero, Michael, primary, Li, Ming, primary, Weiss, Jessica, primary, Sakashita, Shingo, primary, Zaslaver, Olga, primary, Yu, Man, primary, Caudy, Amy A., primary, St-Pierre, Julie, primary, Hawkins, Cynthia, primary, Kislinger, Thomas, primary, Liu, Geoffrey, primary, Shepherd, Frances A., primary, Tsao, Ming-Sound, primary, and Moran, Michael F., primary

Published
2023
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9. Supplementary Data 2 from Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer

Author

Mirhadi, Shideh, primary, Zhang, Wen, primary, Pham, Nhu-An, primary, Karimzadeh, Fereshteh, primary, Pintilie, Melania, primary, Tong, Jiefei, primary, Taylor, Paul, primary, Krieger, Jonathan, primary, Pitcher, Bethany, primary, Sykes, Jenna, primary, Wybenga-Groot, Leanne, primary, Fladd, Christopher, primary, Xu, Jing, primary, Wang, Tao, primary, Cabanero, Michael, primary, Li, Ming, primary, Weiss, Jessica, primary, Sakashita, Shingo, primary, Zaslaver, Olga, primary, Yu, Man, primary, Caudy, Amy A., primary, St-Pierre, Julie, primary, Hawkins, Cynthia, primary, Kislinger, Thomas, primary, Liu, Geoffrey, primary, Shepherd, Frances A., primary, Tsao, Ming-Sound, primary, and Moran, Michael F., primary

Published
2023
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10. Table S1 from Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer

Author

Mirhadi, Shideh, primary, Zhang, Wen, primary, Pham, Nhu-An, primary, Karimzadeh, Fereshteh, primary, Pintilie, Melania, primary, Tong, Jiefei, primary, Taylor, Paul, primary, Krieger, Jonathan, primary, Pitcher, Bethany, primary, Sykes, Jenna, primary, Wybenga-Groot, Leanne, primary, Fladd, Christopher, primary, Xu, Jing, primary, Wang, Tao, primary, Cabanero, Michael, primary, Li, Ming, primary, Weiss, Jessica, primary, Sakashita, Shingo, primary, Zaslaver, Olga, primary, Yu, Man, primary, Caudy, Amy A., primary, St-Pierre, Julie, primary, Hawkins, Cynthia, primary, Kislinger, Thomas, primary, Liu, Geoffrey, primary, Shepherd, Frances A., primary, Tsao, Ming-Sound, primary, and Moran, Michael F., primary

Published
2023
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11. Supplementary Data 1 from Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer

Author

Mirhadi, Shideh, primary, Zhang, Wen, primary, Pham, Nhu-An, primary, Karimzadeh, Fereshteh, primary, Pintilie, Melania, primary, Tong, Jiefei, primary, Taylor, Paul, primary, Krieger, Jonathan, primary, Pitcher, Bethany, primary, Sykes, Jenna, primary, Wybenga-Groot, Leanne, primary, Fladd, Christopher, primary, Xu, Jing, primary, Wang, Tao, primary, Cabanero, Michael, primary, Li, Ming, primary, Weiss, Jessica, primary, Sakashita, Shingo, primary, Zaslaver, Olga, primary, Yu, Man, primary, Caudy, Amy A., primary, St-Pierre, Julie, primary, Hawkins, Cynthia, primary, Kislinger, Thomas, primary, Liu, Geoffrey, primary, Shepherd, Frances A., primary, Tsao, Ming-Sound, primary, and Moran, Michael F., primary

Published
2023
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12. Data from Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer

Author

Mirhadi, Shideh, primary, Zhang, Wen, primary, Pham, Nhu-An, primary, Karimzadeh, Fereshteh, primary, Pintilie, Melania, primary, Tong, Jiefei, primary, Taylor, Paul, primary, Krieger, Jonathan, primary, Pitcher, Bethany, primary, Sykes, Jenna, primary, Wybenga-Groot, Leanne, primary, Fladd, Christopher, primary, Xu, Jing, primary, Wang, Tao, primary, Cabanero, Michael, primary, Li, Ming, primary, Weiss, Jessica, primary, Sakashita, Shingo, primary, Zaslaver, Olga, primary, Yu, Man, primary, Caudy, Amy A., primary, St-Pierre, Julie, primary, Hawkins, Cynthia, primary, Kislinger, Thomas, primary, Liu, Geoffrey, primary, Shepherd, Frances A., primary, Tsao, Ming-Sound, primary, and Moran, Michael F., primary

Published
2023
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13. Supplementary Figure 1 from Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer

Author

Mirhadi, Shideh, primary, Zhang, Wen, primary, Pham, Nhu-An, primary, Karimzadeh, Fereshteh, primary, Pintilie, Melania, primary, Tong, Jiefei, primary, Taylor, Paul, primary, Krieger, Jonathan, primary, Pitcher, Bethany, primary, Sykes, Jenna, primary, Wybenga-Groot, Leanne, primary, Fladd, Christopher, primary, Xu, Jing, primary, Wang, Tao, primary, Cabanero, Michael, primary, Li, Ming, primary, Weiss, Jessica, primary, Sakashita, Shingo, primary, Zaslaver, Olga, primary, Yu, Man, primary, Caudy, Amy A., primary, St-Pierre, Julie, primary, Hawkins, Cynthia, primary, Kislinger, Thomas, primary, Liu, Geoffrey, primary, Shepherd, Frances A., primary, Tsao, Ming-Sound, primary, and Moran, Michael F., primary

Published
2023
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15. Data from ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma

Author

Sachdeva, Rohit, primary, Wu, Megan, primary, Smiljanic, Sandra, primary, Kaskun, Oleksandra, primary, Ghannad-Zadeh, Kimia, primary, Celebre, Angela, primary, Isaev, Keren, primary, Morrissy, A. Sorana, primary, Guan, Jennifer, primary, Tong, Jiefei, primary, Chan, Jeffrey, primary, Wilson, Taylor M., primary, Al-Omaishi, Sayf, primary, Munoz, David G., primary, Dirks, Peter B., primary, Moran, Michael F., primary, Taylor, Michael D., primary, Reimand, Jüri, primary, and Das, Sunit, primary

Published
2023
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16. Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer

Author

Mirhadi, Shideh, primary, Zhang, Wen, additional, Pham, Nhu-An, additional, Karimzadeh, Fereshteh, additional, Pintilie, Melania, additional, Tong, Jiefei, additional, Taylor, Paul, additional, Krieger, Jonathan, additional, Pitcher, Bethany, additional, Sykes, Jenna, additional, Wybenga-Groot, Leanne, additional, Fladd, Christopher, additional, Xu, Jing, additional, Wang, Tao, additional, Cabanero, Michael, additional, Li, Ming, additional, Weiss, Jessica, additional, Sakashita, Shingo, additional, Zaslaver, Olga, additional, Yu, Man, additional, Caudy, Amy A., additional, St-Pierre, Julie, additional, Hawkins, Cynthia, additional, Kislinger, Thomas, additional, Liu, Geoffrey, additional, Shepherd, Frances A., additional, Tsao, Ming-Sound, additional, and Moran, Michael F., additional

Published
2022
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17. A feed forward loop enforces YAP/TAZ signaling during tumorigenesis

Author

Gill, Mandeep K., Christova, Tania, Zhang, Ying Y., Gregorieff, Alex, Zhang, Liang, Narimatsu, Masahiro, Song, Siyuan, Xiong, Shawn, Couzens, Amber L., Tong, Jiefei, Krieger, Jonathan R., Moran, Michael F., Zlotta, Alexandre R., van der Kwast, Theodorus H., Gingras, Anne-Claude, Sicheri, Frank, Wrana, Jeffrey L., and Attisano, Liliana

Published
2018
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19. A Strategy for Modulation of Enzymes in the Ubiquitin System

Author

Ernst, Andreas, Avvakumov, George, Tong, Jiefei, Fan, Yihui, Zhao, Yanling, Alberts, Philipp, Persaud, Avinash, Walker, John R., Neculai, Ana-Mirela, Neculai, Dante, Vorobyov, Andrew, Garg, Pankaj, Beatty, Linda, Chan, Pak-Kei, Juang, Yu-Chi, Landry, Marie-Claude, Yeh, Christina, Zeqiraj, Elton, Karamboulas, Konstantina, Allali-Hassani, Abdellah, Vedadi, Masoud, Tyers, Mike, Moffat, Jason, Sicheri, Frank, Pelletier, Laurence, Durocher, Daniel, Raught, Brian, Rotin, Daniela, Yang, Jianhua, Moran, Michael F., Dhe-Paganon, Sirano, and Sidhu, Sachdev S.

Published
2013
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20. Molecular heterogeneity of non‐small cell lung carcinoma patient‐derived xenografts closely reflect their primary tumors

Author

Wang, Dennis, Pham, NhuAn, Tong, Jiefei, Sakashita, Shingo, Allo, Ghassan, Kim, Lucia, Yanagawa, Naoki, Raghavan, Vibha, Wei, Yuhong, To, Christine, Trinh, Quang M., Starmans, Maud H.W., ChanSengYue, Michelle A., Chadwick, Dianne, Li, Lei, Zhu, ChangQi, Liu, Ni, Li, Ming, Lee, Sharon, Ignatchenko, Vladimir, Strumpf, Dan, Taylor, Paul, Moghal, Nadeem, Liu, Geoffrey, Boutros, Paul C., Kislinger, Thomas, Pintilie, Melania, Jurisica, Igor, Shepherd, Frances A., McPherson, John D., Muthuswamy, Lakshmi, Moran, Michael F., and Tsao, MingSound

Published
2017
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21. Engineered SH2 Domains for Targeted Phosphoproteomics

Author

Martyn, Gregory D., primary, Veggiani, Gianluca, additional, Kusebauch, Ulrike, additional, Morrone, Seamus R., additional, Yates, Bradley P., additional, Singer, Alex U., additional, Tong, Jiefei, additional, Manczyk, Noah, additional, Gish, Gerald, additional, Sun, Zhi, additional, Kurinov, Igor, additional, Sicheri, Frank, additional, Moran, Michael F., additional, Moritz, Robert L., additional, and Sidhu, Sachdev S., additional

Published
2022
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25. Cancer proteome and metabolite changes linked to SHMT2

Author

Tong, Jiefei, primary, Krieger, Jonathan R., additional, Taylor, Paul, additional, Bagshaw, Rick, additional, Kang, Jae, additional, Jeedigunta, Swathi, additional, Wybenga-Groot, Leanne E., additional, Zhang, Wen, additional, Badr, Heba, additional, Mirhadi, Shideh, additional, Pham, Nhu-An, additional, Coyaud, Étienne, additional, Yu, Man, additional, Li, Ming, additional, Cabanero, Michael, additional, Raught, Brian, additional, Maynes, Jason T., additional, Hawkins, Cynthia, additional, Tsao, Ming Sound, additional, and Moran, Michael F., additional

Published
2020
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27. Serine-1321-independent regulation of the micro 1 adult skeletal muscle Na+ channel by protein kinase C

Author

Bendahhou, Said, Cummins, Theodore R., Potts, Jerald F., Tong, Jiefei, and Agnew, William S.

Subjects
Guillain-Barre syndrome -- Physiological aspects, Protein kinases -- Physiological aspects, Sodium channels -- Physiological aspects, Science and technology
Abstract

A study has been conducted to examine the role of protein kinase C (PKC) in the regulation of the micro 1 adult skeletal muscle Na+ channel. Constructs of micro1-S1321A were generated by altering the serine-1321 PKC site in transfected human embryonic kidney cells by PCR site-directed mutagenesis. Maximal phosphorylation by PKC reduced peak Na+ currents by 90% and caused a -15 mV shift in the inactivation current to speed up inactivation. Mutation of serine-1321 had no effect on channel current and inactivation level. These results suggest that PKC regulates the Na+ channel by resembling the response of inhibitory factors present in the serum of skeletal muscle cells.

Published
1995

28. Selected Reaction Monitoring (SRM) Analysis of Epidermal Growth Factor Receptor (EGFR) in Formalin Fixed Tumor Tissue

Author

Hembrough Todd, Thyparambil Sheeno, Liao Wei-Li, Darfler Marlene M, Abdo Joseph, Bengali Kathleen M, Taylor Paul, Tong Jiefei, Lara-Guerra Humberto, Waddell Thomas K, Moran Michael F, Tsao Ming-Sound, Krizman David B, and Burrows Jon

Subjects
Formalin fixed, FFPE, EGFR, Gefitinib, Targeted therapy, Patient tissue, Quantitative, Personalized medicine, Molecular diagnostics, Non-small cell lung cancer, Medicine
Abstract

Abstract Background Analysis of key therapeutic targets such as epidermal growth factor receptor (EGFR) in clinical tissue samples is typically done by immunohistochemistry (IHC) and is only subjectively quantitative through a narrow dynamic range. The development of a standardized, highly-sensitive, linear, and quantitative assay for EGFR for use in patient tumor tissue carries high potential for identifying those patients most likely to benefit from EGFR-targeted therapies. Methods A mass spectrometry-based Selected Reaction Monitoring (SRM) assay for the EGFR protein (EGFR-SRM) was developed utilizing the Liquid Tissue®-SRM technology platform. Tissue culture cells (n = 4) were analyzed by enzyme-linked immunosorbent assay (ELISA) to establish quantitative EGFR levels. Matching formalin fixed cultures were analyzed by the EGFR-SRM assay and benchmarked against immunoassay of the non-fixed cultured cells. Xenograft human tumor tissue (n = 10) of non-small cell lung cancer (NSCLC) origin and NSCLC patient tumor tissue samples (n = 23) were microdissected and the EGFR-SRM assay performed on Liquid Tissue lysates prepared from microdissected tissue. Quantitative curves and linear regression curves for correlation between immunoassay and SRM methodology were developed in Excel. Results The assay was developed for quantitation of a single EGFR tryptic peptide for use in FFPE patient tissue with absolute specificity to uniquely distinguish EGFR from all other proteins including the receptor tyrosine kinases, IGF-1R, cMet, Her2, Her3, and Her4. The assay was analytically validated against a collection of tissue culture cell lines where SRM analysis of the formalin fixed cells accurately reflects EGFR protein levels in matching non-formalin fixed cultures as established by ELISA sandwich immunoassay (R2 = 0.9991). The SRM assay was applied to a collection of FFPE NSCLC xenograft tumors where SRM data range from 305amol/μg to 12,860amol/μg and are consistent with EGFR protein levels in these tumors as previously-reported by western blot and SRM analysis of the matched frozen tissue. In addition, the SRM assay was applied to a collection of histologically-characterized FFPE NSCLC patient tumor tissue where EGFR levels were quantitated from not detected (ND) to 670amol/μg. Conclusions This report describes and evaluates the performance of a robust and reproducible SRM assay designed for measuring EGFR directly in FFPE patient tumor tissue with accuracy at extremely low (attomolar) levels. This assay can be used as part of a complementary or companion diagnostic strategy to support novel therapies currently under development and demonstrates the potential to identify candidates for EGFR-inhibitor therapy, predict treatment outcome, and reveal mechanisms of therapeutic resistance.

Published
2012
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29. ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma

Author

Sachdeva, Rohit, primary, Wu, Megan, additional, Smiljanic, Sandra, additional, Kaskun, Oleksandra, additional, Ghannad-Zadeh, Kimia, additional, Celebre, Angela, additional, Isaev, Keren, additional, Morrissy, A. Sorana, additional, Guan, Jennifer, additional, Tong, Jiefei, additional, Chan, Jeffrey, additional, Wilson, Taylor M., additional, Al-Omaishi, Sayf, additional, Munoz, David G., additional, Dirks, Peter B., additional, Moran, Michael F., additional, Taylor, Michael D., additional, Reimand, Jüri, additional, and Das, Sunit, additional

Published
2019
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30. Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer

Author

Wang, Dennis, primary, Pham, Nhu-An, additional, Freeman, Timothy M., additional, Raghavan, Vibha, additional, Navab, Roya, additional, Chang, Jonathan, additional, Zhu, Chang-Qi, additional, Ly, Dalam, additional, Tong, Jiefei, additional, Wouters, Bradly G., additional, Pintilie, Melania, additional, Moran, Michael F., additional, Liu, Geoffrey, additional, Shepherd, Frances A., additional, and Tsao, Ming-Sound, additional

Published
2019
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32. Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15

Author

Teyra, Joan, primary, Singer, Alex U., additional, Schmitges, Frank W., additional, Jaynes, Patrick, additional, Kit Leng Lui, Sarah, additional, Polyak, Maria J., additional, Fodil, Nassima, additional, Krieger, Jonathan R., additional, Tong, Jiefei, additional, Schwerdtfeger, Carsten, additional, Brasher, Bradley B., additional, Ceccarelli, Derek F.J., additional, Moffat, Jason, additional, Sicheri, Frank, additional, Moran, Michael F., additional, Gros, Philippe, additional, Eichhorn, Pieter J.A., additional, Lenter, Martin, additional, Boehmelt, Guido, additional, and Sidhu, Sachdev S., additional

Published
2019
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35. Non-driver somatic alteration burden confers good prognosis in non-small cell lung cancer

Author

Wang, Dennis, primary, Pham, Nhu-An, additional, Freeman, Timothy M., additional, Raghavan, Vibha, additional, Navab, Roya, additional, Pasko, Elena, additional, Chang, Jonathan, additional, Zhu, Chang-Qi, additional, Ly, Dalam, additional, Tong, Jiefei, additional, Wouters, Bradly G., additional, Pintilie, Melania, additional, Moran, Michael F., additional, Shepherd, Frances A., additional, and Tsao, Ming-Sound, additional

Published
2018
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37. The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

Author

Xie, Jinglin L., primary, Qin, Longguang, additional, Miao, Zhengqiang, additional, Grys, Ben T., additional, Diaz, Jacinto De La Cruz, additional, Ting, Kenneth, additional, Krieger, Jonathan R., additional, Tong, Jiefei, additional, Tan, Kaeling, additional, Leach, Michelle D., additional, Ketela, Troy, additional, Moran, Michael F., additional, Krysan, Damian J., additional, Boone, Charles, additional, Andrews, Brenda J., additional, Selmecki, Anna, additional, Ho Wong, Koon, additional, Robbins, Nicole, additional, and Cowen, Leah E., additional

Published
2017
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39. Integrated analysis of proteome, phosphotyrosine‐proteome, tyrosine‐kinome, and tyrosine‐phosphatome in acute myeloid leukemia

Author

Tong, Jiefei, primary, Helmy, Mohamed, additional, Cavalli, Florence M. G., additional, Jin, Lily, additional, St‐Germain, Jonathan, additional, Karisch, Robert, additional, Taylor, Paul, additional, Minden, Mark D., additional, Taylor, Michael D., additional, Neel, Benjamin G., additional, Bader, Gary D., additional, and Moran, Michael F., additional

Published
2017
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42. PUB052 Proteome Signatures and New Cancer Drivers

Author

Zhang, Wen, primary, Sakashita, Shingo, additional, Pintilie, Melania, additional, Pitcher, Bethany, additional, Tong, Jiefei, additional, Taylor, Paul, additional, Pham, Nhu-An, additional, Li, Ming, additional, Wang, Tao, additional, Cabanero, Michael, additional, Tsao, Ming, additional, and Moran, Michael, additional

Published
2017
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43. Engineered SH2 domains with tailored specificities and enhanced affinities for phosphoproteome analysis.

Author

Veggiani, Gianluca, Huang, Haiming, Yates, Bradley P., Tong, Jiefei, Kaneko, Tomonori, Joshi, Rakesh, Li, Shawn S.C., Moran, Michael F., Gish, Gerald, and Sidhu, Sachdev S.

Abstract

Protein phosphorylation is the most abundant post‐translational modification in cells. Src homology 2 (SH2) domains specifically recognize phosphorylated tyrosine (pTyr) residues to mediate signaling cascades. A conserved pocket in the SH2 domain binds the pTyr side chain and the EF and BG loops determine binding specificity. By using large phage‐displayed libraries, we engineered the EF and BG loops of the Fyn SH2 domain to alter specificity. Engineered SH2 variants exhibited distinct specificity profiles and were able to bind pTyr sites on the epidermal growth factor receptor, which were not recognized by the wild‐type Fyn SH2 domain. Furthermore, mass spectrometry showed that SH2 variants with additional mutations in the pTyr‐binding pocket that enhanced affinity were highly effective for enrichment of diverse pTyr peptides within the human proteome. These results showed that engineering of the EF and BG loops could be used to tailor SH2 domain specificity, and SH2 variants with diverse specificities and high affinities for pTyr residues enabled more comprehensive analysis of the human phosphoproteome. Statement: Src Homology 2 (SH2) domains are modular domains that recognize phosphorylated tyrosine embedded in proteins, transducing these post‐translational modifications into cellular responses. Here we used phage display to engineer hundreds of SH2 domain variants with altered binding specificities and enhanced affinities, which enabled efficient and differential enrichment of the human phosphoproteome for analysis by mass spectrometry. These engineered SH2 domain variants will be useful tools for elucidating the molecular determinants governing SH2 domains binding specificity and for enhancing analysis and understanding of the human phosphoproteome. [ABSTRACT FROM AUTHOR]

Published
2019
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44. Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors

Author

Wang, Dennis, primary, Pham, Nhu-An, additional, Tong, Jiefei, additional, Sakashita, Shingo, additional, Allo, Ghassan, additional, Kim, Lucia, additional, Yanagawa, Naoki, additional, Raghavan, Vibha, additional, Wei, Yuhong, additional, To, Christine, additional, Trinh, Quang M., additional, Starmans, Maud H.W., additional, Chan-Seng-Yue, Michelle A., additional, Chadwick, Dianne, additional, Li, Lei, additional, Zhu, Chang-Qi, additional, Liu, Ni, additional, Li, Ming, additional, Lee, Sharon, additional, Ignatchenko, Vladimir, additional, Strumpf, Dan, additional, Taylor, Paul, additional, Moghal, Nadeem, additional, Liu, Geoffrey, additional, Boutros, Paul C., additional, Kislinger, Thomas, additional, Pintilie, Melania, additional, Jurisica, Igor, additional, Shepherd, Frances A., additional, McPherson, John D., additional, Muthuswamy, Lakshmi, additional, Moran, Michael F., additional, and Tsao, Ming-Sound, additional

Published
2016
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45. Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2

Author

Matsumoto, Yoshinori, primary, La Rose, Jose, additional, Kent, Oliver A., additional, Wagner, Melany J., additional, Narimatsu, Masahiro, additional, Levy, Aaron D., additional, Omar, Mitchell H., additional, Tong, Jiefei, additional, Krieger, Jonathan R., additional, Riggs, Emily, additional, Storozhuk, Yaryna, additional, Pasquale, Julia, additional, Ventura, Manuela, additional, Yeganeh, Behzad, additional, Post, Martin, additional, Moran, Michael F., additional, Grynpas, Marc D., additional, Wrana, Jeffrey L., additional, Superti-Furga, Giulio, additional, Koleske, Anthony J., additional, Pendergast, Ann Marie, additional, and Rottapel, Robert, additional

Published
2016
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47. Identification of human plasma cells with a lamprey monoclonal antibody

Author

Yu, Cuiling, primary, Liu, Yanling, additional, Chan, Justin Tze Ho, additional, Tong, Jiefei, additional, Li, Zhihua, additional, Shi, Mengyao, additional, Davani, Dariush, additional, Parsons, Marion, additional, Khan, Srijit, additional, Zhan, Wei, additional, Kyu, Shuya, additional, Grunebaum, Eyal, additional, Campisi, Paolo, additional, Propst, Evan J., additional, Jaye, David L., additional, Trudel, Suzanne, additional, Moran, Michael F., additional, Ostrowski, Mario, additional, Herrin, Brantley R., additional, Lee, F. Eun-Hyung, additional, Sanz, Ignacio, additional, Cooper, Max D., additional, and Ehrhardt, Götz R.A., additional

Published
2016
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48. Abstract B2-01: Integrated omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact

Author

Moran, Michael F., primary, Kislinger, Thomas, additional, Li, Lei, additional, Ignatchenko, Vladimir, additional, Wei, Yuhong, additional, To, Christine, additional, Taylor, Paul, additional, Tong, Jiefei, additional, Pham, Nhu An, additional, Pintilie, Melania, additional, Muthuswamy, Lakshmi, additional, Shepherd, Frances A., additional, and Tsao, Ming Sound, additional

Published
2015
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49. Abstract A2-49: Integrated Omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact

Author

Moran, Michael F., primary, Kislinger, Thomas, additional, Li, Lei, additional, Ignatchenko, Vladimir, additional, Wei, Yuhong, additional, To, Christine, additional, Taylor, Paul, additional, Tong, Jiefei, additional, Pham, Nhu An, additional, Pintilie, Melania, additional, Muthuswamy, Lakshmi, additional, Shepherd, Frances A., additional, and Tsao, Ming Sound, additional

Published
2015
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50. Abstract SY33-04: Integrated omic analysis of lung cancer reveals metabolism-proteome signatures with prognostic impact

Author

Moran, Michael F., primary, Li, Lei, additional, Wei, Yuhong, additional, Taylor, Paul, additional, To, Christine, additional, Tong, Jiefei, additional, Ignatchenko, Vladimir, additional, Pintilie, Melania, additional, Pham, Nhu-An, additional, Zhang, Wen, additional, Muthuswamy, Lakshmi, additional, Shepherd, Frances A., additional, Kislinger, Thomas, additional, and Tsao, Ming S., additional

Published
2015
Full Text
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