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18 results on '"Tong, Tianying"'

9. Multi-kingdom gut microbiota analyses define bacterial-fungal interplay and microbial markers of pan-cancer immunotherapy across cohorts

Author

Huang, Xiaowen, primary, Hu, Muni, additional, Sun, Tiantian, additional, Li, Jiantao, additional, Zhou, Yilu, additional, Yan, Yuqing, additional, Xuan, Baoqin, additional, Wang, Jilin, additional, Xiong, Hua, additional, Ji, Linhua, additional, Zhu, Xiaoqiang, additional, Tong, Tianying, additional, Ning, Lijun, additional, Ma, Yanru, additional, Zhao, Ying, additional, Ding, Jinmei, additional, Guo, Zhigang, additional, Zhang, Youwei, additional, Fang, Jing-Yuan, additional, Hong, Jie, additional, and Chen, Haoyan, additional

Published
2023
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11. Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis

Author

Ma, Yanru, Zhang, Xinyu, Xuan, Baoqin, Li, Danjie, Yin, Nan, Ning, Lijun, Zhou, Yi-Lu, Yan, Yuqing, Tong, Tianying, Zhu, Xiaoqiang, Huang, Xiaowen, Hu, Muni, Wang, Zhenhua, Cui, Zhe, Li, Huabin, Wang, Jiqiu, Fang, Jing-Yuan, Liu, Ruixin, Chen, Haoyan, and Hong, Jie

Abstract

Background and aimsDeregulation of RNA N6-methyladenosine (m6A) modification in intestinal epithelial cells (IECs) influences intestinal immune cells and leads to intestinal inflammation. We studied the function of fat mass-and obesity-associated protein (FTO), one of the m6A demethylases, in patients with ulcerative colitis (UC).MethodsWe analysed colon tissues of Ftoflox/flox; Villin-cre mice and their Ftoflox/floxlittermates with dextran sulfate sodium (DSS) using real-time PCR and 16s rRNA sequencing. RNA and methylated RNA immunoprecipitation sequencing were used to analyse immunocytes and IECs. Macrophages were treated with conditioned medium of FTO-knockdown MODE-K cells or sphingosine-1-phosphate (S1P) and analysed for gene expression. Liquid chromatograph mass spectrometry identified C16-ceramide.ResultsFTO downregulation was identified in our in-house cohort and external cohorts of UC patients. Dysbiosis of gut microbiota, increased infiltration of proinflammatory macrophages, and enhanced differentiation of Th17 cells were observed in Ftoflox/flox;Villin-cre mice under DSS treatment. FTO deficiency resulted in an increase in m6A modification and a decrease in mRNA stability of CerS6, the gene encoding ceramide synthetase, leading to the downregulation of CerS6 and the accumulation of S1P in IECs. Subsequentially, the secretion of S1P by IECs triggered proinflammatory macrophages to secrete serum amyloid A protein 1/3, ultimately inducing Th17 cell differentiation. In addition, through bioinformatic analysis and experimental validation, we identified UC patients with lower FTO expression might respond better to vedolizumab treatment.ConclusionsFTO downregulation promoted UC by decreasing CerS6 expression, leading to increased S1P accumulation in IECs and aggravating colitis via m6A-dependent mechanisms. Lower FTO expression in UC patients may enhance their response to vedolizumab treatment.

Published
2024
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12. Identification and investigation of depression-related molecular subtypes in inflammatory bowel disease and the anti-inflammatory mechanisms of paroxetine

Author

Ning, Lijun, primary, Wang, Xinyuan, additional, Xuan, Baoqin, additional, Ma, Yanru, additional, Yan, Yuqing, additional, Gao, Ziyun, additional, Tong, Tianying, additional, Cui, Zhe, additional, Chen, Haoyan, additional, Li, Xiaobo, additional, Hong, Jie, additional, and Wang, Zhenhua, additional

Published
2023
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14. Urea Cycle Activation Triggered by Host–Microbiota Maladaptation Driving Colorectal Tumorigenesis

Author

Chen, Haoyan, primary, Tong, Tianying, additional, Lu, Shi-Yuan, additional, Zhao, Gang, additional, Xuan, Baoqin, additional, Ji, Linhua, additional, Yan, Yuqing, additional, Song, Linhong, additional, Zhao, Licong, additional, Xie, Yile, additional, Leng, Xiaoxu, additional, Zhang, Xinyu, additional, Cui, Yun, additional, Chen, Xiaoyu, additional, Xiong, Hua, additional, Yu, TaChung, additional, Li, Xiaobo, additional, Sun, Tiantian, additional, Wang, Zheng, additional, Chen, Jin-Xian, additional, Chen, Ying-Xuan, additional, Hong, Jie, additional, and Fang, Jing-Yuan, additional

Published
2022
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15. Enterotoxigenic Bacteroides fragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p

Author

Cao, Yingying, primary, Wang, Zhenhua, additional, Yan, Yuqing, additional, Ji, Linhua, additional, He, Jie, additional, Xuan, Baoqin, additional, Shen, Chaoqin, additional, Ma, Yanru, additional, Jiang, Shanshan, additional, Ma, Dan, additional, Tong, Tianying, additional, Zhang, Xinyu, additional, Gao, Ziyun, additional, Zhu, Xiaoqiang, additional, Fang, Jing-Yuan, additional, Chen, Haoyan, additional, and Hong, Jie, additional

Published
2021
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17. Health-related quality of life among Chinese patients with Crohn's disease: a cross-sectional survey using the EQ-5D-5L.

Author

Ziyun Gao, Pei Wang, Jie Hong, Yuqing Yan, Tianying Tong, Bin Wu, Jun Hu, Zhenhua Wang, Gao, Ziyun, Wang, Pei, Hong, Jie, Yan, Yuqing, Tong, Tianying, Wu, Bin, Hu, Jun, and Wang, Zhenhua

Subjects
CROHN'S disease, CHINESE people, QUALITY of life, FISHER exact test, CHI-squared test
Abstract

Background: Crohn's disease (CD) is a chronic disease that may have an adverse impact on health-related quality of life (HRQoL). This study aimed to describe the HRQoL of CD patients and assess correlating factors using the EQ-5D-5L in China.Methods: We recruited CD patients at Shanghai Renji Hospital from October 2018 to May 2019. The data collected included demographic and clinical information, medical expenditures, and EQ-5D-5L questionnaire responses. The chi-square test or Fisher's exact test was applied to analyse the proportion of patients in subgroups at each level. After the selection of correlating variables by univariate analysis, multivariate regression analyses were used to explore the correlating factors of HRQoL in CD patients.Results: A total of 202 CD inpatients with a mean disease duration of 3.3 years were enrolled in the study. A total of 71.8% of patients were males, and 49.5% of patients were aged between 30 and 49 years. The average EQ-5D-5L utility score was 0.85, with a standard deviation (SD) of 0.12. Males, ileum lesions, remission status, and lower expenditure predicted higher EQ-5D-5L scores. In each EQ-5D-5L dimension, the proportion of patients differed significantly by gender, disease activity and location subgroup. In the multivariate regression models, being in an active CD state and using antibiotics had significantly adverse impacts on HRQoL (p < 0.05).Conclusions: CD may have a significant negative impact on HRQoL in Chinese CD patients. Being in an active phase of the disease and using antibiotics were identified as affecting HRQoL. [ABSTRACT FROM AUTHOR]

Published
2022
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18. ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5

Author

Shen, Chaoqin, primary, Yan, Tingting, additional, Tong, Tianying, additional, Shi, Debin, additional, Ren, Linlin, additional, Zhang, Youwei, additional, Zhang, Xinyu, additional, Cao, Yingying, additional, Yan, Yuqing, additional, Ma, Yanru, additional, Zhu, Xiaoqiang, additional, Tian, Xianglong, additional, Fang, Jing-Yuan, additional, Chen, Haoyan, additional, Ji, Linhua, additional, Hong, Jie, additional, and Xuan, Baoqin, additional

Published
2020
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