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BackgroundIn May–June 2023, an unprecedented outbreak of human respiratory syncytial virus (HRSV) infections occurred in a kindergarten, Zhejiang Province, China. National, provincial, and local public health officials investigated the cause of the outbreak and instituted actions to control its spread.MethodsWe interviewed patients with the respiratory symptoms by questionnaire. Respiratory samples were screened for six respiratory pathogens by real-time quantitative polymerase chain reaction (RT-PCR). The confirmed cases were further sequenced of G gene to confirm the HRSV genotype. A phylogenetic tree was reconstructed by maximum likelihood method.ResultsOf the 103 children in the kindergarten, 45 were classified as suspected cases, and 25 cases were confirmed by RT-PCR. All confirmed cases were identified from half of classes. 36% (9/25) were admitted to hospital, none died. The attack rate was 53.19%. The median ages of suspected and confirmed cases were 32.7 months and 35.8 months, respectively. Nine of 27 confirmed cases lived in one community. Only two-family clusters among 88 household contacts were HRSV positive. A total of 18 of the G gene were obtained from the confirmed cases. Phylogenetic analyses revealed that 16 of the sequences belonged to the HRSV B/BA9 genotype, and the other 2 sequences belonged to the HRSV A/ON1 genotype. The school were closed on June 9 and the outbreak ended on June 15.ConclusionThese findings suggest the need for an increased awareness of HRSV coinfections outbreak in the kindergarten, when HRSV resurges in the community after COVID-19 pandemic.

WNW-directed faults are widespread in eastern China, but debates regarding their distributions and evolutionary processes remain unsettled. Based on the latest 3-D seismic data, a series of WNW-directed faults south of the Liaodong Bay subbasin was identified, for which the evolution and formation mechanisms were discussed. The results show that four WNW-directed faults are characterized by poor continuity and nearly parallel orientations. Vertically, they exhibit listric geometries and cut through Paleozoic and Mesozoic formations. Since the late Triassic, these faults began as reverse faults under nearly S-N horizontal compression. In the Jurassic, those faults maintained their reverse-faulting activities with dramatically decreased intensities. In the Early Cretaceous, the WNW-directed faults were changed into normal faults under regional extension and were influenced by the sinistral strike-slip movement along the Tan-Lu fault zone. In the Late Cretaceous, the WNW-directed normal faults probably stopped moving due to a regional compressional event. During the Paleogene, the WNW-directed faults were reactivated with decreased intensities and were cut by NNE-directed faults. Here, we emphasize that the evolution of the WNW-directed faults could shed light on the regional tectonics. The WNW-trending faults that developed in the Liaodong Bay subbasin are closely related to the faults in the Yanshan orogenic belt. Therefore, investigating the characteristics and origin of WNW-induced faults will provide evidence for the tectonic evolution of the North China Block. In addition, the development of WNW-directed faults in the southern Liaodong Bay subbasin was conducive to the formation of buried Mesozoic and Paleozoic hills and hydrocarbon accumulations. In addition, we suggest that the compressional segment of the conjugated strike-slip transition zone that was formed by the interaction of the WNW- and NNE-directed strike-slip faults was conducive to hydrocarbon accumulations.

Background: Infantile development of phthalate metabolism is crucial for risk assessment of endocrine disruption and has important toxico/pharmacokinetic implications. Objectives: To characterize temporal variability in urinary phthalate metabolites in infants and to examine their growth-dependent detoxification. Methods: In this cohort study, urine samples (n = 876) from 155 healthy Chinese infants were collected serially at eight time points from birth to one year old. Free and total (i.e., free plus glucuronide conjugated) phthalate metabolites (PMEs) were measured by LC/MS/MS. Time variability in PMEs and PME metabolism capacity was characterized using intraclass correlation coefficients (ICCs) and linear mixed regression models. Results: Concentrations of most PMEs changed significantly, with ICCs ranging from 0.213 to 0.318, and trends increased significantly over time (p

Node localization plays an important role in many current and envisioned WSN applications. Most of existing algorithms are not applicable for networks in a concave area. To address this problem, a novel greedy optimization localization algorithm (GOLA) is proposed. The key of GOLA is the design of neighborhood function which only uses distances between neighbor nodes to generate a new set of estimated locations from an old one, two correction operations are used to alleviate the flip ambiguity. Furthermore, a method of initial solution generation is given. Both rangebased and range-free localization can use GOLA to estimate locations of nodes if distances between neighbor nodes are measured by hardware or estimated by distance estimation algorithms. Simulation results indicate that GOLA can achieve more accurate and reliable localization results in a concave area. [ABSTRACT FROM AUTHOR]