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1. Do palliative care patients and relatives think it would be acceptable to use Bispectral index (BIS) technology to monitor palliative care patients’ levels of consciousness? A qualitative exploration with interviews and focus groups for the I-CAN-CARE research programme

Author

Krooupa, Anna-Maria, Stone, Patrick, McKeever, Stephen, Seddon, Kathy, Davis, Sarah, Sampson, Elizabeth L., Tookman, Adrian, Martin, Jonathan, Nambisan, Vinnie, and Vivat, Bella

Published
2022
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4. 48 What kinds of spiritual and/or religious interventions for the wellbeing of people living with terminal illnesses did RCTs investigate in 2011–22? Findings from a Cochrane review, updating a previous review (Candy et al. 2012)

Author

Vivat, Bella, primary, Speck, Peter, additional, Uddin, Inayah, additional, Rohde, Gudrun, additional, White, Nicola, additional, Candy, Bridget, additional, Jones, Louise, additional, Tookman, Adrian, additional, and King, Michael, additional

Published
2023
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8. Allele-informed copy number evaluation of plasma DNA samples from metastatic prostate cancer patients: the PCF_SELECT consortium assay

Author

Orlando, Francesco, Romanel, Alessandro, Trujillo, Blanca, Sigouros, Michael, Wetterskog, Daniel, Quaini, Orsetta, Leone, Gianmarco, Xiang, Jenny Z, Wingate, Anna, Tagawa, Scott, Jayaram, Anuradha, Linch, Mark, Swanton, Charles, Jamal-Hanjani, Mariam, Abbosh, Chris, Zaccaria, Simone, Hessey, Sonya, Shiu, Kai-Keen, Bridgewater, John, Hochhauser, Daniel, Forster, Martin, Lee, Siow-Ming, Ahmad, Tanya, Papadatos-Pastos, Dionysis, Janes, Sam, Van Loo, Peter, Enfield, Katey, McGranahan, Nicholas, Huebner, Ariana, Quezada, Sergio, Beck, Stephan, Parker, Peter, Enver, Tariq, Hynds, Robert E, Dijkstra, Krijn, Pearce, David R, Falzon, Mary, Proctor, Ian, Sinclair, Ron, Lok, Chi-wah, Rhodes, Zoe, Moore, David, Marafioti, Teresa, Mitchison, Miriam, Ellery, Peter, Sivakumar, Monica, Brandner, Sebastian, Rowan, Andrew, Hiley, Crispin, Veeriah, Selvaraju, Shaw, Heather, Attard, Gert, Naceur-Lombardelli, Cristina, Toncheva, Antonia, Prymas, Paulina, Watkins, Tom, Bailey, Chris, Ruiz, Carlos Martinez, Litchfield, Kevin, Al-Bakir, Maise, Kanu, Nnenna, Ward, Sophie, Lim, Emilia, Reading, James, Chain, Benny, Alba, Blanca Trujillo, Akay, Melek, Flanagan, Adrienne, Biswas, Dhruva, Pich, Oriol, Dietzen, Michelle, Puttick, Clare, Colliver, Emma, Magness, Alistair, Angelova, Mihaela, Black, James, Lucas, Olivia, Hill, William, Liu, Wing-Kin, Frankell, Alexander, Magno, Neil, Athanasopoulou, Foteini, Wilson, Gareth, Rosenthal, Rachel, Salgado, Roberto, Lee, Claudia, Grigoriadis, Kristiana, Al-Sawaf, Othman, Karasaki, Takahiro, Bunkum, Abigail, Noorani, Imran, Benafif, Sarah, Barbe, Vittorio, Bola, Supreet, Vainauskas, Osvaldas, Hasan, Mahedi, Lise, Stefano, Leone, GianMarco, Alifrangis, Constantine, McGovern, Ursula, Thol, Kerstin, Gamble, Samuel, Ung, Seng Kuong, Sahwangarrom, Teerapon, Marin, Claudia Peinador, Wong, Sophia, Pawlik, Piotr, Gishen, Faye, Tookman, Adrian, Stone, Paddy, Stirling, Caroline, Turajlic, Samra, Larkin, James, Pickering, Lisa, Furness, Andrew, Young, Kate, Drake, Will, Edmonds, Kim, Hunter, Nikki, Mangwende, Mary, Pearce, Karla, Grostate, Lauren, Au, Lewis, Spain, Lavinia, Shepherd, Scott, Yan, Haixi, Shum, Ben, Tippu, Zayd, Hanley, Brian, Spencer, Charlotte, Emmerich, Max, Gerard, Camille, Schmitt, Andreas Michael, Del Rosario, Lyra, Carlyle, Eleanor, Lewis, Charlotte, Holt, Lucy, Lucanas, Analyn, O'Flaherty, Molly, Hazell, Steve, Mudhar, Hardeep, Messiou, Christina, Latifoltojar, Arash, Fendler, Annika, Byrne, Fiona, Pallinkonda, Husayn, Lobon, Irene, Coulton, Alex, Cattin, Anne Laure, Deng, Daqi, Feng, Geoffrey Hugang, Rowan, Andew, Yousaf, Nadia, Popat, Sanjay, Curtis, Olivia, Milner-Watts, Charlotte, Stamp, Gordon, Nye, Emma, Murra, Aida, Korteweg, Justine, Kelly, Denise, Terry, Lauren, Biano, Jennifer, Peat, Kema, Kelly, Kayleigh, Hill, Peter, Josephs, Debra, Irshad, Sheeba, Chandra, Ashish, Spicer, James, Mahadeva, Ula, Green, Anna, Stewart, Ruby, Iredale, Lara-Rose, Mackay, Tina, Deakin, Ben, Enting, Debra, Rudman, Sarah, Ghosh, Sharmistha, Karapagniotou, Lena, Pintus, Elias, Tutt, Andrew, Howlett, Sarah, Michalarea, Vasiliki, Brenton, James, Caldas, Carlos, Fitzgerald, Rebecca, Jimenez-Linan, Merche, Provenzano, Elena, Cluroe, Alison, Paterson, Anna, Aitken, Sarah, Allinson, Kieren, Stewart, Grant, McDermott, Ultan, Beddowes, Emma, Maughan, Tim, Ansorge, Olaf, Campbell, Peter, Roxburgh, Patricia, Fraser, Sioban, Kidd, Andrew, Blyth, Kevin, Le Quesne, John, Krebs, Matthew, Blackhall, Fiona, Summers, Yvonne, Oliveira, Pedro, Ortega-Franco, Ana, Dive, Caroline, Gomes, Fabio, Carter, Mat, Dransfield, Jo, Thomas, Anne, Fennell, Dean, Shaw, Jacqui, Naidu, Babu, Baijal, Shobhit, Tanchel, Bruce, Langman, Gerald, Robinson, Andrew, Collard, Martin, Cockcroft, Peter, Ferris, Charlotte, Bancroft, Hollie, Kerr, Amy, Middleton, Gary, Webb, Joanne, Kadiri, Salma, Colloby, Peter, Olisemeke, Bernard, Wilson, Rodelaine, Tomlinson, Ian, McNeish, Iain, Jogai, Sanjay, Holden, Samantha, Fernandes, Tania, Hampton, Blanche, McKenzie, Mairead, Hackshaw, Allan, Sharp, Abby, Chan, Kitty, Farrelly, Laura, Bridger, Hayley, Leslie, Rachel, Consortium, PEACE, Rubin, Mark A, Wyatt, Alexander W, Beltran, Himisha, Attard, Gerhardt, and Demichelis, Francesca

Subjects
Chemical Biology & High Throughput, Signalling & Oncogenes, Human Biology & Physiology, Ecology,Evolution & Ethology, Genome Integrity & Repair, Tumour Biology, Genetics & Genomics, Computational & Systems Biology
Abstract

Sequencing of cell-free DNA (cfDNA) in cancer patients’ plasma offers a minimally-invasive solution to detect tumor cell genomic alterations to aid real-time clinical decision-making. The reliability of copy number detection decreases at lower cfDNA tumor fractions, limiting utility at earlier stages of the disease. To test a novel strategy for detection of allelic imbalance, we developed a prostate cancer bespoke assay, PCF_SELECT, that includes an innovative sequencing panel covering ∼25 000 high minor allele frequency SNPs and tailored analytical solutions to enable allele-informed evaluation. First, we assessed it on plasma samples from 50 advanced prostate cancer patients. We then confirmed improved detection of genomic alterations in samples with

Published
2022
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9. Additional file 1 of Do palliative care patients and relatives think it would be acceptable to use Bispectral index (BIS) technology to monitor palliative care patients’ levels of consciousness? A qualitative exploration with interviews and focus groups for the I-CAN-CARE research programme

Author

Krooupa, Anna-Maria, Stone, Patrick, McKeever, Stephen, Seddon, Kathy, Davis, Sarah, Sampson, Elizabeth L., Tookman, Adrian, Martin, Jonathan, Nambisan, Vinnie, and Vivat, Bella

Abstract

Additional file 1. Interview/focus group topic guide (minor adaptations made for each participant group as appropriate.

Published
2022
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11. Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma

Author

Au, Lewis, primary, Hatipoglu, Emine, additional, Robert de Massy, Marc, additional, Litchfield, Kevin, additional, Beattie, Gordon, additional, Rowan, Andrew, additional, Schnidrig, Desiree, additional, Thompson, Rachael, additional, Byrne, Fiona, additional, Horswell, Stuart, additional, Fotiadis, Nicos, additional, Hazell, Steve, additional, Nicol, David, additional, Shepherd, Scott T.C., additional, Fendler, Annika, additional, Mason, Robert, additional, Del Rosario, Lyra, additional, Edmonds, Kim, additional, Lingard, Karla, additional, Sarker, Sarah, additional, Mangwende, Mary, additional, Carlyle, Eleanor, additional, Attig, Jan, additional, Joshi, Kroopa, additional, Uddin, Imran, additional, Becker, Pablo D., additional, Sunderland, Mariana Werner, additional, Akarca, Ayse, additional, Puccio, Ignazio, additional, Yang, William W., additional, Lund, Tom, additional, Dhillon, Kim, additional, Vasquez, Marcos Duran, additional, Ghorani, Ehsan, additional, Xu, Hang, additional, Spencer, Charlotte, additional, López, José I., additional, Green, Anna, additional, Mahadeva, Ula, additional, Borg, Elaine, additional, Mitchison, Miriam, additional, Moore, David A., additional, Proctor, Ian, additional, Falzon, Mary, additional, Pickering, Lisa, additional, Furness, Andrew J.S., additional, Reading, James L., additional, Salgado, Roberto, additional, Marafioti, Teresa, additional, Jamal-Hanjani, Mariam, additional, Kassiotis, George, additional, Chain, Benny, additional, Larkin, James, additional, Swanton, Charles, additional, Quezada, Sergio A., additional, Turajlic, Samra, additional, Abbosh, Chris, additional, Shiu, Kai-Keen, additional, Bridgewater, John, additional, Hochhauser, Daniel, additional, Forster, Martin, additional, Lee, Siow-Ming, additional, Ahmad, Tanya, additional, Papadatos-Pastos, Dionysis, additional, Janes, Sam, additional, Van Loo, Peter, additional, Enfield, Katey, additional, McGranahan, Nicholas, additional, Huebner, Ariana, additional, Beck, Stephan, additional, Parker, Peter, additional, Walczak, Henning, additional, Enver, Tariq, additional, Hynds, Rob, additional, Sinclair, Ron, additional, Lok, Chi-wah, additional, Rhodes, Zoe, additional, Moore, David, additional, Khiroya, Reena, additional, Trevisan, Giorgia, additional, Ellery, Peter, additional, Linch, Mark, additional, Brandner, Sebastian, additional, Hiley, Crispin, additional, Veeriah, Selvaraju, additional, Razaq, Maryam, additional, Shaw, Heather, additional, Attard, Gert, additional, Akther, Mita Afroza, additional, Naceur-Lombardelli, Cristina, additional, Manzano, Lizi, additional, Al-Bakir, Maise, additional, Summan, Simranpreet, additional, Kanu, Nnenna, additional, Ward, Sophie, additional, Asghar, Uzma, additional, Lim, Emilia, additional, Gishen, Faye, additional, Tookman, Adrian, additional, Stone, Paddy, additional, Stirling, Caroline, additional, Hunter, Nikki, additional, Vaughan, Sarah, additional, Spain, Lavinia, additional, Yan, Haixi, additional, Shum, Ben, additional, Yousaf, Nadia, additional, Popat, Sanjay, additional, Curtis, Olivia, additional, Stamp, Gordon, additional, Toncheva, Antonia, additional, Nye, Emma, additional, Murra, Aida, additional, Korteweg, Justine, additional, Josephs, Debra, additional, Chandra, Ashish, additional, Spicer, James, additional, Stewart, Ruby, additional, Iredale, Lara-Rose, additional, Mackay, Tina, additional, Deakin, Ben, additional, Enting, Debra, additional, Rudman, Sarah, additional, Ghosh, Sharmistha, additional, Karapagniotou, Lena, additional, Pintus, Elias, additional, Tutt, Andrew, additional, Howlett, Sarah, additional, Michalarea, Vasiliki, additional, Brenton, James, additional, Caldas, Carlos, additional, Fitzgerald, Rebecca, additional, Jimenez-Linan, Merche, additional, Provenzano, Elena, additional, Cluroe, Alison, additional, Stewart, Grant, additional, Watts, Colin, additional, Gilbertson, Richard, additional, McDermott, Ultan, additional, Tavare, Simon, additional, Beddowes, Emma, additional, Roxburgh, Patricia, additional, Biankin, Andrew, additional, Chalmers, Anthony, additional, Fraser, Sioban, additional, Oien, Karin, additional, Kidd, Andrew, additional, Blyth, Kevin, additional, Krebs, Matt, additional, Blackhall, Fiona, additional, Summers, Yvonne, additional, Dive, Caroline, additional, Marais, Richard, additional, Gomes, Fabio, additional, Carter, Mat, additional, Dransfield, Jo, additional, Le Quesne, John, additional, Fennell, Dean, additional, Shaw, Jacqui, additional, Naidu, Babu, additional, Baijal, Shobhit, additional, Tanchel, Bruce, additional, Langman, Gerald, additional, Robinson, Andrew, additional, Collard, Martin, additional, Cockcroft, Peter, additional, Ferris, Charlotte, additional, Bancroft, Hollie, additional, Kerr, Amy, additional, Middleton, Gary, additional, Webb, Joanne, additional, Kadiri, Salma, additional, Colloby, Peter, additional, Olisemeke, Bernard, additional, Wilson, Rodelaine, additional, Tomlinson, Ian, additional, Jogai, Sanjay, additional, Ottensmeier, Christian, additional, Harrison, David, additional, Loda, Massimo, additional, Flanagan, Adrienne, additional, McKenzie, Mairead, additional, Hackshaw, Allan, additional, Ledermann, Jonathan, additional, Chan, Kitty, additional, Sharp, Abby, additional, Farrelly, Laura, additional, Bridger, Hayley, additional, Challacombe, Ben, additional, Chowdhury, Simon, additional, Drake, William, additional, Fernando, Archana, additional, Harrison-Phipps, Karen, additional, Hill, Peter, additional, Horsfield, Catherine, additional, O'Brien, Tim, additional, Olsburgh, Jonathon, additional, Polson, Alexander, additional, Varia, Mary, additional, and Verma, Hema, additional

Published
2021
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16. CONTRIBUTORS

Author

Aberg, Judith A., primary, Abernethy, Amy P., additional, Abrahm, Janet L., additional, Adolph, Michael, additional, Aherne, Michael, additional, Allsopp, K., additional, Altisent, Rogelio, additional, Alvarez, Carmen Fernandez, additional, Amigo, Pablo, additional, Anderson, Wendy G., additional, Ang, Sik Kim, additional, Antonelli, Tiziana, additional, Armstrong, John, additional, Armstrong, Wendy S., additional, Arnold, Robert M., additional, Arranz, Pilar, additional, Augustyns, Koen, additional, Sáenz-Diez, Isabel Barreiro-Meiro, additional, Barreto, Pilar, additional, Barton, Debra, additional, Bates, Ursula, additional, Fernandez-Creuchet Santos, Maria B., additional, Bátiz, Jacinto, additional, Benedetti, Costantino, additional, Bennani-Baiti, Nabila, additional, Bennett, Michael I., additional, Berger, Kevin, additional, Bhatnagar, Mamta, additional, Bicanovsky, Lesley, additional, Blue, Lynda, additional, Bobb, Barton, additional, Body, Jean-Jacques, additional, Borasio, Gian Domenico, additional, Borreani, Claudia, additional, Bozzetti, Federico, additional, Bozzetti, Valentina, additional, Braybrooke, Jason, additional, Breitbart, William, additional, Bresnihan, Barry, additional, Broeckaert, Bert, additional, Bruera, Eduardo, additional, Brune, Kay, additional, Buckhout, Bradley, additional, Butow, Phyllis N., additional, Byock, Ira, additional, Byrne, Anthony, additional, Byrne, Clare, additional, Cable-Williams, Beryl E., additional, Callin, Sarah E., additional, Casarett, David, additional, Casper, David, additional, Cassell, Eric J., additional, Cassileth, Barrie, additional, Castagno, Emanuele, additional, Centeno, Carlos, additional, Ceranski, Walter, additional, Ceulemans, Lucas, additional, Chadha, Meghna, additional, Chamberlain, Bruce H., additional, Chang, Eric L., additional, Chang, Victor T., additional, Chochinov, Harvey Max, additional, Chow, Edward, additional, Christ, Grace, additional, Clark, Katherine, additional, Clarke, Stephen, additional, Clayton, Josephine M., additional, Cleary, James F., additional, Clein, Lawrence J., additional, Clemens, Katri Elina, additional, Clemens, Libby, additional, Colebunders, Robert, additional, Connor, Steven R., additional, Conraads, Viviane, additional, Cooney, Colm, additional, Costantini, Massimo, additional, Couceiro, Azucena, additional, Covington, Holly, additional, Cowan, John D., additional, Coyne, Patrick, additional, Crawford, Garnet, additional, Creedon, Brian, additional, Cronin, Hilary, additional, Cullen, Garret, additional, Cummings, Jennifer E., additional, Currow, David C., additional, Daeninck, Paul J., additional, Dalinis, Pamela, additional, Das, Prajnan, additional, Davis, Mellar P., additional, Davison, Sara N., additional, Deamant, Catherine, additional, de Lima, Liliana, additional, Delany, Conor P., additional, Demeulenaere, Peter, additional, Dergham, Lena, additional, Derycke, Noël, additional, Dhupar, Rajeev, additional, Dicato, Mario, additional, Dickerson, Edwin D., additional, Dickman, Andrew, additional, Dietrich, Maria, additional, Dixon, Pamela, additional, Dodd, Philip C., additional, D'Olimpio, James T., additional, Dombernowsky, Per, additional, Dooley, Michael, additional, Dudgeon, Deborah, additional, Dunn, Geoffrey P., additional, Dunwoodie, David, additional, Eades, Jane, additional, El Osta, Badi, additional, Elbert-Avila, Katja, additional, Ellershaw, John, additional, Estfan, Bassam, additional, Exton, Louise, additional, Fairchild, Alysa, additional, Farrelly, Matthew, additional, Fassbender, Konrad, additional, Faulhaber, Jason, additional, Fearon, Kenneth C.H., additional, Fenelon, Lynda E., additional, Ferson, Peter F., additional, Feyer, Petra, additional, Filbet, Marilene, additional, Firth, Pam, additional, FitzGerald, Susan F., additional, Flood, Hugh D., additional, Floriani, Francesca Crippa, additional, Ford, Paul J., additional, Fortner, Barry, additional, Foth, Darlene, additional, Fowler, Bridget, additional, Frame, Karen, additional, Fraser, Thomas G., additional, Frost, Fred, additional, Fulham, Michael J., additional, Gagnon, Pierre R., additional, Gallagher, Lisa M., additional, Gambles, Maureen, additional, Giri, Subhasis K., additional, Glare, Paul, additional, Goh, Cynthia R., additional, Gómez-Batiste, Xavier, additional, Gramlich, Leah, additional, Grassi, Luigi, additional, Grauer, Phyllis A., additional, Green, Claire, additional, Griffiths, Gareth, additional, Griffo, Yvona, additional, Groninger, Hunter, additional, Gruenewald, David A., additional, Gubili, Jyothirmai, additional, Gutgsell, Terence L., additional, Gwyther, Elizabeth, additional, Haber, Paul S., additional, Haemers, Achiel, additional, Haley, Mindi C., additional, Hanna, Mazen A., additional, Hardy, Janet R., additional, Haselkorn, Jodie, additional, Hauser, Katherine, additional, Heaven, Cathy, additional, Herman, Michael, additional, Herrstedt, Jørn, additional, Higgins, Stephen, additional, Higginson, Irene J., additional, Hilden, Joanne M., additional, Hillenbrand, Kathryn L., additional, Hinz, Burkhard, additional, Homsi, Jade, additional, Hood, Kerry, additional, Hou, Juliet Y., additional, Hubens, Guy, additional, Hudson, Peter, additional, Hughes, John G., additional, Hunt, John, additional, Hurwitz, Craig A., additional, Ibinson, James, additional, Janjan, Nora, additional, Jaspers, Birgit, additional, Jehser, Thomas, additional, Joffe, A. Mark, additional, John, Laurence, additional, Johnstone, Jennie, additional, Jones, J. Stephen, additional, Kane, Javier R., additional, Karafa, Matthew T., additional, Keaveny, Andrew P., additional, Keefe, Dorothy M.K., additional, Kelso, Catherine McVearry, additional, Kenny, Rose Anne, additional, Kern, Martina, additional, Khoshknabi, Dilara Seyidova, additional, Kirkova, Jordanka, additional, Kirsh, Kenneth L., additional, Kissane, David W., additional, Klaschik, Eberhard, additional, Komurcu, Seref, additional, Kottke-Marchant, Kandice, additional, Kozell, Kathryn M., additional, Krishnan, Sunil, additional, Kuban, Deborah, additional, Laber, Damian A., additional, Lagman, Ruth L., additional, Lalla, Rajesh V., additional, Lane, Deforia, additional, Larkin, Philip J., additional, Lasheen, Wael, additional, Lawlor, Peter, additional, LeGrand, Susan B., additional, Lens, Vincent, additional, Leskuski, Dona, additional, Levack, Pamela, additional, Levetown, Marcia, additional, Lewandowski, Jeanne G., additional, Lewis, William R., additional, Librach, S. Lawrence, additional, Lichtenthal, Wendy G., additional, Lickiss, J. Norelle, additional, Lijoi, Stefano, additional, Lin, Edward, additional, Lipman, Arthur G., additional, Livrozet, Jean-Michel, additional, Lloyd-Williams, Mari, additional, Logan, Richard M., additional, Martín, Francisco López-Lara, additional, Loprinzi, Charles L., additional, Loughnane, John, additional, Lucey, Michael, additional, Lyckholm, Laurie, additional, Macmillan, Carol, additional, Mair, Frances, additional, Makoni, Stephen N., additional, Malik, Bushra, additional, Malone, Kevin, additional, Maltoni, Marco, additional, Mani, Aruna, additional, Marchand, Lucille R., additional, Mareiniss, Darren P., additional, Marsland, Anna L., additional, Marston, Joan, additional, Martinez, Julia Romero, additional, Martínez de Ubago, Isabel, additional, Martins, Lina M., additional, Maughan, Timothy S., additional, Mayland, Catriona, additional, McClement, Susan E., additional, McCutcheon, Ian, additional, McGee, Michael F., additional, McGill, Neil, additional, McNamara, Stephen, additional, McPherson, Mary Lynn, additional, McQuay, Henry, additional, McQuillan, Regina, additional, McQuown, Robert E., additional, Meiring, Michelle, additional, Mercadante, Sebastiano, additional, Meyer, Elaine C., additional, Miller, Randy D., additional, Millerick, Yvonne, additional, Miniero, Roberto, additional, Mohamed, Armin, additional, Mooka, Busi, additional, Morrison, Helen M., additional, Muir, J. Cameron, additional, Mulcahy, Fiona, additional, Mulcahy, Hugh E., additional, Muller, Monica, additional, Müller-Busch, H. Christof, additional, Murray, Scott A., additional, Nauck, Friedemann, additional, Neasham, Katherine, additional, Nkosi, Busisiwe, additional, Noble, Simon, additional, Noguera, Antonio, additional, Nowak, Anna K., additional, Nuñez-Olarte, Juan, additional, Obbens, Eugenie A.M.T., additional, O'Brien, Tony, additional, Olden, Megan, additional, O'Leary, Norma, additional, Oliver, David, additional, Oliviere, David, additional, Omlin, Aurelius G., additional, Osenga, Kaci, additional, O'Shea, Diarmuid, additional, Ostgathe, Christophe, additional, Ottery, Faith D., additional, Ouellette, Michel, additional, Overton, Edgar Turner, additional, Palacios, Moné, additional, Palmer, Robert, additional, Palmer, Teresa, additional, Paradis, Carmen, additional, Parala, Armida G., additional, Pascual-López, Antonio, additional, Passik, Steven D., additional, Pawlik, Timothy M., additional, Payne, Malcolm, additional, Payne, Sheila, additional, Paz, Silvia, additional, Pereira, José, additional, Perkins, George, additional, Peschardt, Karin, additional, Pessin, Hayley, additional, Peterson, Douglas E., additional, Podichetty, Vinod K., additional, Pollens, Robin, additional, Pontifex, Eliza, additional, Poole, Susan, additional, Porta-Sales, Josep, additional, Poston, Graeme, additional, Powazki, Ruth D., additional, Powderly, William, additional, Pozuelo, Leopoldo, additional, Prommer, Eric, additional, Puchalski, Christina M., additional, Radbruch, Lukas, additional, Raes, David F.J., additional, Read, Jane, additional, Reddy, Anantha, additional, Reger, Steven I., additional, Rehm, Susan J., additional, Reich, Stephen G., additional, Rocafort, Javier, additional, Rosenblatt, Adam, additional, Rushton, Cynda Hylton, additional, Russell, K. Mitchell, additional, Ryan, Karen, additional, Rybicki, Lisa A., additional, Sacerdote, Paola, additional, Sahgal, Vinod, additional, Ann Sammon, Mary, additional, Sandrock, Dirk, additional, Sands, Mark, additional, Schilling, Denise L., additional, Schulz, Valerie Nocent, additional, Schum, Lisa N., additional, Selwyn, Peter, additional, Shadd, Joshua, additional, Shapiro, Charles L., additional, Sharif, Aktham, additional, Sharp, Helen M., additional, Shepard, Kirk V., additional, Sherwood, J. Timothy, additional, Shrestha, Nabin K., additional, Skipworth, Richard J.E., additional, Smith, Howard S., additional, Solomon, Mildred Z., additional, de Prado Otero, Diego Soto, additional, Spencer, Denise Wells, additional, Spice, Ron, additional, Spiegel, David, additional, Srivastava, Manish, additional, Staffurth, John N., additional, Starling, Randall, additional, Stewart, Grant D., additional, Stjernswärd, Jan, additional, Strasser, Florian, additional, Strauss, Edna, additional, Strohscheer, Imke, additional, Summey, Brett Taylor, additional, Sutton, Graham, additional, Sykes, Nigel P., additional, Taege, Alan J., additional, Tamburini, Marcello, additional, Tarumi, Yoko, additional, Tassinari, Davide, additional, Tattersall, Martin H.N., additional, Theil, Karl S., additional, Thomas, Keri, additional, Tookman, Adrian, additional, Torrubia, María P., additional, Towers, Anna, additional, Tsoi, Daphne, additional, Tucker, Rodney O., additional, Tulsky, James A., additional, Tunick, Rachel A., additional, Turner, Claire, additional, Twaddle, Martha L., additional, Twomey, Marie, additional, Ullrich, Christina, additional, Urch, Catherine E., additional, Vachon, Mary L.S., additional, Van den Eynden, Bart, additional, Vigano, Antonio, additional, Vlieghe, Erika, additional, Volandes, Angelo E., additional, Voltz, Raymond, additional, Walker, Paul W., additional, Watanabe, Sharon, additional, Weber, Michael A., additional, Weinstein, Elizabeth, additional, Weinstein, Sharon M., additional, Weise, Kathryn L., additional, Weisenfluh, Sherri, additional, Welsh, John, additional, White, Clare, additional, Wilson, Donna M., additional, Wolfe, Joanne, additional, Yavuzsen, Tugba, additional, Yee, Albert J.M., additional, Yerian, Lisa M., additional, and Zucchetti, Elena, additional

Published
2009
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18. Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue

Author

Litchfield, Kevin, primary, Stanislaw, Stacey, additional, Spain, Lavinia, additional, Gallegos, Lisa L., additional, Rowan, Andrew, additional, Schnidrig, Desiree, additional, Rosenbaum, Heidi, additional, Harle, Alexandre, additional, Au, Lewis, additional, Hill, Samantha M., additional, Tippu, Zayd, additional, Thomas, Jennifer, additional, Thompson, Lisa, additional, Xu, Hang, additional, Horswell, Stuart, additional, Barhoumi, Aoune, additional, Jones, Carol, additional, Leith, Katherine F., additional, Burgess, Daniel L., additional, Watkins, Thomas B.K., additional, Lim, Emilia, additional, Birkbak, Nicolai J., additional, Lamy, Philippe, additional, Nordentoft, Iver, additional, Dyrskjøt, Lars, additional, Pickering, Lisa, additional, Hazell, Stephen, additional, Jamal-Hanjani, Mariam, additional, Larkin, James, additional, Swanton, Charles, additional, Alexander, Nelson R., additional, Turajlic, Samra, additional, Abbosh, Chris, additional, Shiu, Kai-Keen, additional, Bridgewater, John, additional, Hochhauser, Daniel, additional, Forster, Martin, additional, Lee, Siow-Ming, additional, Ahmad, Tanya, additional, Papadatos-Pastos, Dionysis, additional, Janes, Sam, additional, Van Loo, Peter, additional, Enfield, Katey, additional, McGranahan, Nicholas, additional, Huebner, Ariana, additional, Quezada, Sergio, additional, Beck, Stephan, additional, Parker, Peter, additional, Walczak, Henning, additional, Enver, Tariq, additional, Hynds, Rob, additional, Falzon, Mary, additional, Proctor, Ian, additional, Sinclair, Ron, additional, Lok, Chi-wah, additional, Rhodes, Zoe, additional, Moore, David, additional, Marafioti, Teresa, additional, Borg, Elaine, additional, Mitchison, Miriam, additional, Khiroya, Reena, additional, Trevisan, Giorgia, additional, Ellery, Peter, additional, Linch, Mark, additional, Brandner, Sebastian, additional, Hiley, Crispin, additional, Veeriah, Selvaraju, additional, Razaq, Maryam, additional, Shaw, Heather, additional, Attard, Gert, additional, Akther, Mita Afroza, additional, Naceur-Lombardelli, Cristina, additional, Manzano, Lizi, additional, Al-Bakir, Maise, additional, Summan, Simranpreet, additional, Kanu, Nnenna, additional, Ward, Sophie, additional, Asghar, Uzma, additional, Gishen, Faye, additional, Tookman, Adrian, additional, Stone, Paddy, additional, Stirling, Caroline, additional, Furness, Andrew, additional, Edmonds, Kim, additional, Hunter, Nikki, additional, Sarker, Sarah, additional, Vaughan, Sarah, additional, Mangwende, Mary, additional, Pearce, Karla, additional, Shepherd, Scott, additional, Yan, Haixi, additional, Shum, Ben, additional, Carlyle, Eleanor, additional, Hazell, Steve, additional, Fendler, Annika, additional, Byrne, Fiona, additional, Yousaf, Nadia, additional, Popat, Sanjay, additional, Curtis, Olivia, additional, Stamp, Gordon, additional, Toncheva, Antonia, additional, Nye, Emma, additional, Murra, Aida, additional, Korteweg, Justine, additional, Sheikh, Nahid, additional, Josephs, Debra, additional, Chandra, Ashish, additional, Spicer, James, additional, Mahadeva, Ula, additional, Green, Anna, additional, Stewart, Ruby, additional, Iredale, Lara-Rose, additional, Mackay, Tina, additional, Deakin, Ben, additional, Enting, Debra, additional, Rudman, Sarah, additional, Ghosh, Sharmistha, additional, Karapagniotou, Lena, additional, Pintus, Elias, additional, Tutt, Andrew, additional, Howlett, Sarah, additional, Michalarea, Vasiliki, additional, Brenton, James, additional, Caldas, Carlos, additional, Fitzgerald, Rebecca, additional, Jimenez-Linan, Merche, additional, Provenzano, Elena, additional, Cluroe, Alison, additional, Stewart, Grant, additional, Watts, Colin, additional, Gilbertson, Richard, additional, McDermott, Ultan, additional, Tavare, Simon, additional, Beddowes, Emma, additional, Roxburgh, Patricia, additional, Biankin, Andrew, additional, Chalmers, Anthony, additional, Fraser, Sioban, additional, Oien, Karin, additional, Kidd, Andrew, additional, Blyth, Kevin, additional, Krebs, Matt, additional, Blackhall, Fiona, additional, Summers, Yvonne, additional, Dive, Caroline, additional, Marais, Richard, additional, Gomes, Fabio, additional, Carter, Mat, additional, Dransfield, Jo, additional, Le Quesne, John, additional, Fennell, Dean, additional, Shaw, Jacqui, additional, Naidu, Babu, additional, Baijal, Shobhit, additional, Tanchel, Bruce, additional, Langman, Gerald, additional, Robinson, Andrew, additional, Collard, Martin, additional, Cockcroft, Peter, additional, Ferris, Charlotte, additional, Bancroft, Hollie, additional, Kerr, Amy, additional, Middleton, Gary, additional, Webb, Joanne, additional, Kadiri, Salma, additional, Colloby, Peter, additional, Olisemeke, Bernard, additional, Wilson, Rodelaine, additional, Tomlinson, Ian, additional, Jogai, Sanjay, additional, Ottensmeier, Christian, additional, Harrison, David, additional, Loda, Massimo, additional, Flanagan, Adrienne, additional, McKenzie, Mairead, additional, Hackshaw, Allan, additional, Ledermann, Jonathan, additional, Sharp, Abby, additional, Farrelly, Laura, additional, and Bridger, Hayley, additional

Published
2020
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32. Spiritual beliefs may affect outcome of bereavement: prospective study. (Papers)

Author

Walsh, Kiri, King, Michael, Jones, Louise, Tookman, Adrian, and Blizard, Robert

Subjects
Spirituality -- Research, Bereavement -- Research, Health, Research
Abstract

Abstract Objective To explore the relation between spiritual beliefs and resolution of bereavement. Design Prospective cohort study of people about to be bereaved with follow up continuing for 14 months [...]

Published
2002

37. Understanding care when cure is not likely for young adults who face cancer: a realist analysis of data from patients, families and healthcare professionals

Author

Kenten, Charlotte, primary, Ngwenya, Nothando, additional, Gibson, Faith, additional, Flatley, Mary, additional, Jones, Louise, additional, Pearce, Susie, additional, Wong, Geoff, additional, Black, Kath M, additional, Haig, Sue, additional, Hough, Rachael, additional, Hurlow, Adam, additional, Stirling, L Caroline, additional, Taylor, Rachel M, additional, Tookman, Adrian, additional, and Whelan, Jeremy, additional

Published
2019
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40. Palliative care in advanced dementia; A mixed methods approach for the development of a complex intervention

Author

Tookman Adrian, Jones Louise, Kukkastenvehmas Riitta, Thuné-Boyle Ingela, Sampson Elizabeth L, King Michael, and Blanchard Martin R

Subjects
Special situations and conditions, RC952-1245
Abstract

Abstract Background There is increasing interest in improving the quality of care that patients with advanced dementia receive when they are dying. Our understanding of the palliative care needs of these patients and the natural history of advanced disease is limited. Many people with advanced dementia have unplanned emergency admissions to the acute hospital; this is a critical event: half will die within 6 months. These patients have complex needs but often lack capacity to express their wishes. Often carers are expected to make decisions. Advance care planning discussions are rarely performed, despite potential benefits such more consistent supportive healthcare, a reduction in emergency admissions to the acute hospital and better resolution of carer bereavement. Design/Methods We have used the MRC complex interventions framework, a "bottom-up" methodology, to develop an intervention for patients with advanced dementia and their carers aiming to 1) define end of life care needs for both patients and carers, 2) pilot a palliative care intervention and 3) produce a framework for advance care planning for patients. The results of qualitative phase 1 work, which involved interviews with carers, hospital and primary care staff from a range of disciplines, have been used to identify key barriers and challenges. For the exploratory trial, 40 patients will be recruited to each of the control and intervention groups. The intervention will be delivered by a nurse specialist. We shall investigate and develop methodology for a phase 3 randomised controlled trial. For example we shall explore the feasibility of randomisation, how best to optimise recruitment, decide on appropriate outcomes and obtain data for power calculations. We will evaluate whether the intervention is pragmatic, feasible and deliverable on acute hospital wards and test model fidelity and its acceptability to carers, patients and staff. Discussion Results of qualitative phase 1 work suggested that carers and staff were keen to discuss these issues and guided the development of the intervention and choice of outcomes. This will be vital in moving to a phase III trial that is pragmatic and feasible for these complex patients within the NHS Trial registration ISRCTN03330837

Published
2008
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41. 44 An evidenced-based heuristics model (or rule of thumb) to improve doctors’ intuition about when patients are imminently dying

Author

White, Nicola, primary, Harries, Priscilla, additional, Harris, Adam JL, additional, Vickerstaff, Victoria, additional, Lodge, Philip, additional, McGowan, Catherine, additional, Minton, Ollie, additional, Tomlinson, Christopher, additional, Tookman, Adrian, additional, Reid, Fiona, additional, and Stone, Patrick, additional

Published
2018
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44. Funding Policies For HIV And AIDS

Author

Hochuli, Vernon, Smith, Suzanne, Parker, Clare, Shaunak, Sunil, Ash, Stephen, Bhatt, Ramesh, Williams, Henrietta, Tookman, Adrian, and Kurowska, Anna

Published
1993

45. Acceptance and commitment therapy for adults with advanced cancer (CanACT): study protocol for a feasibility randomised controlled trial

Author

Low, Joseph, Serfaty, Marc, Davis, Sarah, Vickerstaff, Victoria, Gola, Anna, Omar, Rumana Z., King, Michael, Tookman, Adrian, Austen, Janet St John, Turner, Karen, and Jones, Louise

Subjects
Adult, Randomised control trial, Patient Selection, Acceptance and commitment therapy, Medicine (miscellaneous), Feasibility, Study Protocol, Clinical Protocols, psychological therapy, Advanced cancer, Data Interpretation, Statistical, Neoplasms, Humans, Pharmacology (medical)
Abstract

Background One-third of people with cancer experience psychological distress and may suppress distressing thoughts, emotions, and concerns, leading to further problems. Conventional psychological treatments reduce distress by problem solving, but in advanced cancer, when ill health is progressive and death may be approaching, physical and psychological difficulties are complex and have no simple solutions. Acceptance and Commitment Therapy encourages acknowledgement and acceptance of mental experiences, increasing people’s ability to work with problems that cannot be solved. Previous pilot work in advanced cancer confirms that distress can be associated with an avoidance of experiencing uncomfortable thoughts and emotions. Methods/Design This feasibility randomised controlled trial of Acceptance Commitment Therapy aims to establish parameters for a larger trial. Fifty-four participants with advanced cancer will be randomly allocated to up to eight sessions (each 1 hour) of Acceptance Commitment Therapy or a talking control. Participants will be recruited from those attending outpatient services and hospice day care at three specialist palliative care units in North and East London, United Kingdom. The primary outcome is a measure of functioning in four areas of life (physical, social/family, emotional, and general activity) using the Functional Assessment of Cancer Therapies - General questionnaire at 3 months after randomisation. Secondary outcomes are (i) acceptance using the Acceptance and Action Questionnaire; (ii) psychological distress using the Kessler Psychological Distress Scale; (iii) physical functioning using a timed walk and sit-to-stand test; and (iv) quality of life measures including the Euroqol-5 Dimensions and ICECAP Supportive Care measures. Qualitative data will be collected at 3 months to explore the participants’ experiences of the trial and therapy. Data will be collected on the costs of care. Discussion Data generated on the recruitment, retention, and experience of the interventions and the usefulness of the outcome measures will inform the adaptations required and whether changes in function are consistent with existing data when planning for a sufficiently powered randomised controlled trial. Trial registration ISRCTN13841211 (registered 22 July 2015). Electronic supplementary material The online version of this article (doi:10.1186/s13063-016-1169-8) contains supplementary material, which is available to authorized users.

Published
2016

46. Additional file 1: of Acceptance and commitment therapy for adults with advanced cancer (CanACT): study protocol for a feasibility randomised controlled trial

Author

Low, Joseph, Serfaty, Marc, Davis, Sarah, Vickerstaff, Victoria, Gola, Anna, Rumana Omar, King, Michael, Tookman, Adrian, Austen, Janet, Turner, Karen, and Jones, Louise

Abstract

ACT protocol paper SPIRIT 2013 Checklist (2015 09 30). File outlining how this protocol paper meets the different guidelines from the SPIRIT 2013 Checklist. (DOCX 22 kb)

Published
2016
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48. Acceptance and commitment therapy for adults with advanced cancer (CanACT): A feasibility randomised controlled trial.

Author

Serfaty, Marc, Armstrong, Megan, Vickerstaff, Victoria, Davis, Sarah, Gola, Anna, McNamee, Philip, Omar, Rumana Z., King, Michael, Tookman, Adrian, Jones, Louise, and Low, Joseph T.S.

Subjects
ACCEPTANCE & commitment therapy
Abstract

Objective: To understand the feasibility of recruiting people with advanced cancer into a randomised controlled trial of acceptance and commitment therapy (ACT) vs a standardised talking control (TC) and delivering ACT to this population; to explore the acceptability of outcome measures and generate normative data.Methods: This was a feasibility two-arm randomised controlled trial. Participants were attendees with advanced cancer at one of three hospice-based day-therapy units in London, United Kingdom, who demonstrated low scores on the Functional Assessment of Cancer Therapies-General (FACT-G). The primary end point was 3 months.Results: The recruitment target was 54 participants; 42 people were recruited and randomised to up to eight individual sessions of ACT (n = 20) or TC (n = 22). Eighteen out of 42 (43%) of participants completed the primary outcome at 3 months, and at least one follow-up was available in 30/42 (71%) participants. An exploratory analysis revealed a non-significant adjusted mean difference after 3 months in the main outcome FACT-G of -3.41 (CI = -18.61-11.79) with TC having better functioning. Over 6 months, the adjusted mean difference between trial arms was 2.25 (CI = -6.03-10.52) in favour of ACT.Conclusions: It is feasible to recruit people with advanced cancer in a trial of ACT versus TC. Future research should test the effectiveness of ACT in a fully powered trial. [ABSTRACT FROM AUTHOR]

Published
2019
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50. The clinical and cost effectiveness of cognitive behavioural therapy plus treatment as usual for the treatment of depression in advanced cancer (CanTalk): study protocol for a randomised controlled trial

Author

Serfaty, Marc, primary, King, Michael, additional, Nazareth, Irwin, additional, Tookman, Adrian, additional, Wood, John, additional, Gola, Anna, additional, Aspden, Trefor, additional, Mannix, Kathryn, additional, Davis, Sarah, additional, Moorey, Stirling, additional, and Jones, Louise, additional

Published
2016
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